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Aliases for KMT5C Gene

Aliases for KMT5C Gene

  • Lysine Methyltransferase 5C 2 3 5
  • Lysine (K)-Specific Methyltransferase 5C 2 3
  • Suppressor Of Variegation 4-20 Homolog 2 3 4
  • Lysine-Specific Methyltransferase 5C 3 4
  • Lysine N-Methyltransferase 5C 3 4
  • Su(Var)4-20 Homolog 2 3 4
  • Suv4-20h2 3 4
  • SUV420H2 3 4
  • Suppressor Of Variegation 4-20 Homolog 2 (Drosophila) 2
  • Histone-Lysine N-Methyltransferase SUV420H2 3
  • Histone-Lysine N-Methyltransferase KMT5C 3
  • EC 2.1.1.43 4

External Ids for KMT5C Gene

Previous HGNC Symbols for KMT5C Gene

  • SUV420H2

Summaries for KMT5C Gene

Entrez Gene Summary for KMT5C Gene

  • SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

GeneCards Summary for KMT5C Gene

KMT5C (Lysine Methyltransferase 5C) is a Protein Coding gene. Among its related pathways are Lysine degradation. An important paralog of this gene is KMT5B.

UniProtKB/Swiss-Prot for KMT5C Gene

  • Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KMT5C Gene

Genomics for KMT5C Gene

Regulatory Elements for KMT5C Gene

Enhancers for KMT5C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KMT5C on UCSC Golden Path with GeneCards custom track

Promoters for KMT5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KMT5C Gene

Chromosome:
19
Start:
55,339,210 bp from pter
End:
55,348,121 bp from pter
Size:
8,912 bases
Orientation:
Plus strand

Genomic View for KMT5C Gene

Genes around KMT5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KMT5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KMT5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KMT5C Gene

Proteins for KMT5C Gene

  • Protein details for KMT5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y97-KMT5C_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase KMT5C
    Protein Accession:
    Q86Y97
    Secondary Accessions:
    • Q8WZ10
    • Q9BRZ6

    Protein attributes for KMT5C Gene

    Size:
    462 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    • Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).
    SequenceCaution:
    • Sequence=AAH05842.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL55766.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KMT5C Gene

    Alternative splice isoforms for KMT5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KMT5C Gene

Post-translational modifications for KMT5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KMT5C Gene

No data available for DME Specific Peptides for KMT5C Gene

Domains & Families for KMT5C Gene

Gene Families for KMT5C Gene

Protein Domains for KMT5C Gene

Suggested Antigen Peptide Sequences for KMT5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y97

UniProtKB/Swiss-Prot:

KMT5C_HUMAN :
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
genes like me logo Genes that share domains with KMT5C: view

Function for KMT5C Gene

Molecular function for KMT5C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

Enzyme Numbers (IUBMB) for KMT5C Gene

Gene Ontology (GO) - Molecular Function for KMT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19486527
GO:0042799 histone methyltransferase activity (H4-K20 specific) IEA --
genes like me logo Genes that share ontologies with KMT5C: view
genes like me logo Genes that share phenotypes with KMT5C: view

Animal Models for KMT5C Gene

MGI Knock Outs for KMT5C:

Animal Model Products

miRNA for KMT5C Gene

miRTarBase miRNAs that target KMT5C

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KMT5C

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KMT5C Gene

Localization for KMT5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KMT5C Gene

Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for KMT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IEA --
GO:0005654 nucleoplasm IDA --
GO:0005720 nuclear heterochromatin IDA 19486527
GO:0005721 pericentric heterochromatin IDA 19486527
genes like me logo Genes that share ontologies with KMT5C: view

No data available for Subcellular locations from COMPARTMENTS for KMT5C Gene

Pathways & Interactions for KMT5C Gene

SuperPathways for KMT5C Gene

Superpath Contained pathways
1 Lysine degradation
genes like me logo Genes that share pathways with KMT5C: view

Pathways by source for KMT5C Gene

1 KEGG pathway for KMT5C Gene

Gene Ontology (GO) - Biological Process for KMT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016571 histone methylation IEA --
GO:0034773 histone H4-K20 trimethylation IEA --
genes like me logo Genes that share ontologies with KMT5C: view

No data available for SIGNOR curated interactions for KMT5C Gene

Drugs & Compounds for KMT5C Gene

(4) Drugs for KMT5C Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
Chaetocin Pharma SUV39H1 Inhibitor, SUV39H1 inhibitor 0
UNC 2400 Pharma negative control of UNC1999, Negative control of UNC 1999 (Cat. No. 4904) 0

(3) Additional Compounds for KMT5C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-PFI 2 hydrochloride
1627607-88-8
OICR 9429
UNC 0638
1255517-77-1

(5) Tocris Compounds for KMT5C Gene

Compound Action Cas Number
(S)-PFI 2 hydrochloride Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892) 1627607-88-8
Chaetocin SUV39H1 inhibitor 28097-03-2
OICR 9429 High affinity and selective WDR5 antagonist
UNC 0638 Selective G9a and GLP inhibitor 1255517-77-1
UNC 2400 Negative control of UNC 1999 (Cat. No. 4904) 1433200-49-7
genes like me logo Genes that share compounds with KMT5C: view

Transcripts for KMT5C Gene

Unigene Clusters for KMT5C Gene

Suppressor of variegation 4-20 homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KMT5C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KMT5C Gene

No ASD Table

Relevant External Links for KMT5C Gene

GeneLoc Exon Structure for
KMT5C
ECgene alternative splicing isoforms for
KMT5C

Expression for KMT5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of KMT5C Gene:

KMT5C

SOURCE GeneReport for Unigene cluster for KMT5C Gene:

Hs.590982
genes like me logo Genes that share expression patterns with KMT5C: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KMT5C Gene

Orthologs for KMT5C Gene

This gene was present in the common ancestor of animals.

Orthologs for KMT5C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUV420H2 34
  • 86.4 (n)
  • 88.03 (a)
SUV420H2 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUV420H2 34
  • 86.2 (n)
  • 88.02 (a)
SUV420H2 35
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suv420h2 34
  • 82.03 (n)
  • 81.74 (a)
Suv420h2 16
Suv420h2 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUV420H2 34
  • 98.92 (n)
  • 98.27 (a)
SUV420H2 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suv420h2 34
  • 81.81 (n)
  • 82.83 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SUV420H2 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUV420H2 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4508 34
zebrafish
(Danio rerio)
Actinopterygii suv420h2 35
  • 8 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hmt4-20 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea set-4 35
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9369 35
  • 52 (a)
OneToMany
Species where no ortholog for KMT5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KMT5C Gene

ENSEMBL:
Gene Tree for KMT5C (if available)
TreeFam:
Gene Tree for KMT5C (if available)

Paralogs for KMT5C Gene

Paralogs for KMT5C Gene

genes like me logo Genes that share paralogs with KMT5C: view

Variants for KMT5C Gene

Sequence variations from dbSNP and Humsavar for KMT5C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745273 -- 55,348,423(-) GCCCT(C/T)AAGTC downstream-variant-500B
rs3840910 -- 55,339,025(-) CCCCC(-/T)ACCTC upstream-variant-2KB
rs11084395 -- 55,344,715(+) CAGGA(C/T)GCTGT intron-variant
rs11279508 -- 55,338,551(+) ctctc(A/T)cacac upstream-variant-2KB
rs28454782 -- 55,337,777(+) CACTG(C/T)ACTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KMT5C Gene

Variant ID Type Subtype PubMed ID
esv26533 CNV loss 19812545
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for KMT5C Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KMT5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KMT5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KMT5C Gene

Disorders for KMT5C Gene

Relevant External Links for KMT5C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KMT5C

No disorders were found for KMT5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KMT5C Gene

Publications for KMT5C Gene

  1. The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. (PMID: 19486527) Souza P.P. … Angrand P.O. (BMC Cell Biol. 2009) 2 3 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 65
  4. SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3. (PMID: 25814362) Shinchi Y. … Matsuura N. (Exp. Cell Res. 2015) 3 65
  5. Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. (PMID: 24396869) Wu H. … Min J. (FEBS Lett. 2013) 3 65

Products for KMT5C Gene

Sources for KMT5C Gene

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