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Aliases for KMT5C Gene

Aliases for KMT5C Gene

  • Lysine Methyltransferase 5C 2 3 5
  • Lysine (K)-Specific Methyltransferase 5C 2 3
  • Suppressor Of Variegation 4-20 Homolog 2 3 4
  • Lysine-Specific Methyltransferase 5C 3 4
  • Lysine N-Methyltransferase 5C 3 4
  • Su(Var)4-20 Homolog 2 3 4
  • Suv4-20h2 3 4
  • SUV420H2 3 4
  • Suppressor Of Variegation 4-20 Homolog 2 (Drosophila) 2
  • Histone-Lysine N-Methyltransferase SUV420H2 3
  • Histone-Lysine N-Methyltransferase KMT5C 3
  • EC 2.1.1.43 4

External Ids for KMT5C Gene

Previous HGNC Symbols for KMT5C Gene

  • SUV420H2

Summaries for KMT5C Gene

Entrez Gene Summary for KMT5C Gene

  • SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

GeneCards Summary for KMT5C Gene

KMT5C (Lysine Methyltransferase 5C) is a Protein Coding gene. Among its related pathways are Lysine degradation and PKMTs methylate histone lysines. An important paralog of this gene is KMT5B.

UniProtKB/Swiss-Prot for KMT5C Gene

  • Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KMT5C Gene

Genomics for KMT5C Gene

Regulatory Elements for KMT5C Gene

Enhancers for KMT5C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055337 1.8 FANTOM5 ENCODE dbSUPER 15 +0.6 618 4.0 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC LENG8-AS1 ENSG00000235681 U2AF2 FAM71E2 KMT5C PPP6R1 ZNF628 TMEM238 IL11 TMEM190
GH19G055519 1.6 FANTOM5 Ensembl ENCODE 11.7 +181.0 181000 1.0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 SP3 FIZ1 ZNF471 NAT14 ZNF580 ZNF667 ZNF582-AS1 ZNF667-AS1 ZNF542P U2AF2 ZNF583
GH19G055215 1.5 ENCODE dbSUPER 11.7 -122.5 -122506 2.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 LENG8-AS1 U2AF2 ENSG00000235681 ENSG00000267523 ZNF580 NAT14 ZNF581 FIZ1 ENSG00000267096 ENSG00000267265
GH19G055639 1.4 Ensembl ENCODE 10.8 +303.2 303152 6.5 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 ZNF580 U2AF2 KMT5C FIZ1 ZNF471 CCDC106 PIR41897
GH19G055503 1.3 Ensembl ENCODE 10.8 +164.8 164759 1.6 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF416 FIZ1 ZNF667 ZNF667-AS1 ZNF582-AS1 NAT14 ZNF542P ZNF583 U2AF2 LOC729999 ZNF580
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KMT5C on UCSC Golden Path with GeneCards custom track

Promoters for KMT5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111634 890 2601 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC

Genomic Location for KMT5C Gene

Chromosome:
19
Start:
55,339,210 bp from pter
End:
55,348,121 bp from pter
Size:
8,912 bases
Orientation:
Plus strand

Genomic View for KMT5C Gene

Genes around KMT5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KMT5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KMT5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KMT5C Gene

Proteins for KMT5C Gene

  • Protein details for KMT5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y97-KMT5C_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase KMT5C
    Protein Accession:
    Q86Y97
    Secondary Accessions:
    • Q8WZ10
    • Q9BRZ6

    Protein attributes for KMT5C Gene

    Size:
    462 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    • Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).
    SequenceCaution:
    • Sequence=AAH05842.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL55766.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KMT5C Gene

    Alternative splice isoforms for KMT5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KMT5C Gene

Post-translational modifications for KMT5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KMT5C Gene

No data available for DME Specific Peptides for KMT5C Gene

Domains & Families for KMT5C Gene

Protein Domains for KMT5C Gene

Suggested Antigen Peptide Sequences for KMT5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y97

UniProtKB/Swiss-Prot:

KMT5C_HUMAN :
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
genes like me logo Genes that share domains with KMT5C: view

Function for KMT5C Gene

Molecular function for KMT5C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

Enzyme Numbers (IUBMB) for KMT5C Gene

Gene Ontology (GO) - Molecular Function for KMT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19486527
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0018024 histone-lysine N-methyltransferase activity IEA,TAS --
GO:0042799 histone methyltransferase activity (H4-K20 specific) IEA --
genes like me logo Genes that share ontologies with KMT5C: view
genes like me logo Genes that share phenotypes with KMT5C: view

Animal Models for KMT5C Gene

MGI Knock Outs for KMT5C:

Animal Model Products

CRISPR Products

miRNA for KMT5C Gene

miRTarBase miRNAs that target KMT5C

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KMT5C

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KMT5C Gene

Localization for KMT5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KMT5C Gene

Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KMT5C gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for KMT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005694 chromosome IEA --
GO:0005720 nuclear heterochromatin IDA 19486527
genes like me logo Genes that share ontologies with KMT5C: view

Pathways & Interactions for KMT5C Gene

genes like me logo Genes that share pathways with KMT5C: view

Pathways by source for KMT5C Gene

1 BioSystems pathway for KMT5C Gene
1 KEGG pathway for KMT5C Gene

Gene Ontology (GO) - Biological Process for KMT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0016571 histone methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with KMT5C: view

No data available for SIGNOR curated interactions for KMT5C Gene

Drugs & Compounds for KMT5C Gene

(4) Drugs for KMT5C Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
Chaetocin Pharma SUV39H1 Inhibitor, SUV39H1 inhibitor 0
UNC 2400 Pharma negative control of UNC1999, Negative control of UNC 1999 (Cat. No. 4904) 0

(3) Additional Compounds for KMT5C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-PFI 2 hydrochloride
1627607-88-8
OICR 9429
UNC 0638
1255517-77-1

(5) Tocris Compounds for KMT5C Gene

Compound Action Cas Number
(S)-PFI 2 hydrochloride Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892) 1627607-88-8
Chaetocin SUV39H1 inhibitor 28097-03-2
OICR 9429 High affinity and selective WDR5 antagonist
UNC 0638 Selective G9a and GLP inhibitor 1255517-77-1
UNC 2400 Negative control of UNC 1999 (Cat. No. 4904) 1433200-49-7
genes like me logo Genes that share compounds with KMT5C: view

Transcripts for KMT5C Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KMT5C

Alternative Splicing Database (ASD) splice patterns (SP) for KMT5C Gene

No ASD Table

Relevant External Links for KMT5C Gene

GeneLoc Exon Structure for
KMT5C
ECgene alternative splicing isoforms for
KMT5C

Expression for KMT5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of KMT5C Gene:

KMT5C
genes like me logo Genes that share expression patterns with KMT5C: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KMT5C Gene

Orthologs for KMT5C Gene

This gene was present in the common ancestor of animals.

Orthologs for KMT5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUV420H2 35 34
  • 98.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SUV420H2 34 35
  • 86.4 (n)
dog
(Canis familiaris)
Mammalia SUV420H2 35 34
  • 86.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Suv420h2 35 34
  • 82.03 (n)
OneToOne
Kmt5c 16
rat
(Rattus norvegicus)
Mammalia Suv420h2 34
  • 81.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SUV420H2 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUV420H2 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4508 34
zebrafish
(Danio rerio)
Actinopterygii suv420h2 35
  • 8 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hmt4-20 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea set-4 35
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9369 35
  • 52 (a)
OneToMany
Species where no ortholog for KMT5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KMT5C Gene

ENSEMBL:
Gene Tree for KMT5C (if available)
TreeFam:
Gene Tree for KMT5C (if available)

Paralogs for KMT5C Gene

Paralogs for KMT5C Gene

genes like me logo Genes that share paralogs with KMT5C: view

Variants for KMT5C Gene

Sequence variations from dbSNP and Humsavar for KMT5C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000074924 -- 55,345,754(+) ACACA(C/T)AGATT intron-variant
rs1000162168 -- 55,338,625(+) ACTCT(C/G)TGGCA upstream-variant-2KB
rs1000236246 -- 55,338,918(+) TGGCG(-/AAAC)AAACA upstream-variant-2KB
rs1000334378 -- 55,347,643(+) CCCTG(A/C)GCCAC utr-variant-3-prime
rs1000341786 -- 55,339,258(+) TAAAG(C/T)TTCGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KMT5C Gene

Variant ID Type Subtype PubMed ID
esv26533 CNV loss 19812545
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for KMT5C Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KMT5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KMT5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KMT5C Gene

Disorders for KMT5C Gene

Relevant External Links for KMT5C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KMT5C

No disorders were found for KMT5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KMT5C Gene

Publications for KMT5C Gene

  1. The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. (PMID: 19486527) Souza P.P. … Angrand P.O. (BMC Cell Biol. 2009) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress. (PMID: 26904956) Zhao Z. … Bierhoff H. (Cell Rep 2016) 3 64
  5. SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3. (PMID: 25814362) Shinchi Y. … Matsuura N. (Exp. Cell Res. 2015) 3 64

Products for KMT5C Gene

  • Addgene plasmids for KMT5C

Sources for KMT5C Gene

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