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KMT2C Gene

protein-coding   GIFtS: 44
GCID: GC07M151835

Lysine (K)-Specific Methyltransferase 2C

(Previous name: myeloid/lymphoid or mixed-lineage leukemia 3)
(Previous symbol: MLL3)
  See KMT2C-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysine (K)-Specific Methyltransferase 2C1 2     ALR-Like Protein2
MLL31 2 3 5     Histone-Lysine N-Methyltransferase 2C2
Homologous To ALR Protein2 3     Histone-Lysine N-Methyltransferase MLL32
Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 32 3     Histone-Lysine N-Methyltransferase, H3 Lysine-4 Specific2
HALR2 3     EC 2.1.1.433
KIAA15063 5     Lysine N-Methyltransferase 2C3
Myeloid/Lymphoid Or Mixed-Lineage Leukemia 31     

External Ids:    HGNC: 137261   Entrez Gene: 585082   Ensembl: ENSG000000556097   OMIM: 6068335   UniProtKB: Q8NEZ43   

Export aliases for KMT2C gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KMT2C Gene:
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein
with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET
domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses
histone methylation activity and is involved in transcriptional coactivation. (provided by RefSeq, Jul 2008)

GeneCards Summary for KMT2C Gene:
KMT2C (lysine (K)-specific methyltransferase 2C) is a protein-coding gene. Diseases associated with KMT2C include leukemia. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is KMT2D.

UniProtKB/Swiss-Prot: KMT2C_HUMAN, Q8NEZ4
Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator
complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of
this complex. May be involved in leukemogenesis and developmental disorder

Gene Wiki entry for KMT2C (MLL3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for KMT2C
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): KMT2C promoter sequence
   Search Chromatin IP Primers for KMT2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KMT2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

KMT2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KMT2C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M151835:  view genomic region     (about GC identifiers)

Start:
151,832,010 bp from pter      End:
152,133,090 bp from pter
Size:
301,081 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 151,159,181-151,460,261     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KMT2C_HUMAN, Q8NEZ4 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase 2C  
Size: 4911 amino acids; 541370 Da
Subunit: Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or
KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts
with histone H3
Miscellaneous: Found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid
disorders. Partial duplication of the KMT2C gene are found in the juxtacentromeric region of chromosomes 1, 2, 13
and 21. Juxtacentromeric reshuffling of the KMT2C gene has generated the BAGE genes
4 PDB 3D structures from and Proteopedia for KMT2C:
2YSM (3D)        2YUK (3D)        3UVL (3D)        4ERY (3D)    
Secondary accessions: Q8NC02 Q8NDF6 Q9H9P4 Q9NR13 Q9P222 Q9UDR7
Alternative splicing: 3 isoforms:  Q8NEZ4-1   Q8NEZ4-2   Q8NEZ4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KMT2C: NX_Q8NEZ4

Explore proteomics data for KMT2C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KMT2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_733751.2  
    ENSEMBL proteins: 
     ENSP00000353218   ENSP00000453752   ENSP00000262189   ENSP00000410411   ENSP00000408001  
     ENSP00000454058   ENSP00000403483   ENSP00000410239   ENSP00000347325   ENSP00000439909  

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for KMT2C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 14):
     IPR001594 Znf_DHHC_palmitoyltrfase
     IPR017956 AT_hook_DNA-bd_motif
     IPR001214 SET_dom
     IPR001841 Znf_RING
     IPR003889 FYrich_C

    Graphical View of Domain Structure for InterPro Entry Q8NEZ4

    ProtoNet protein and cluster: Q8NEZ4

    3 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB001594 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: KMT2C_HUMAN, Q8NEZ4
    Domain: The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific
    methylation activity
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. TRX/MLL subfamily
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 DHHC-type zinc finger
    Similarity: Contains 1 FYR C-terminal domain
    Similarity: Contains 1 FYR N-terminal domain
    Similarity: Contains 6 PHD-type zinc fingers
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SET domain


    Find genes that share domains with KMT2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KMT2C_HUMAN, Q8NEZ4
    Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
    specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator
    complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of
    this complex. May be involved in leukemogenesis and developmental disorder
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI12482968
    GO:0008168methyltransferase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0042800histone methyltransferase activity (H3-K4 specific) IDA17500065
         
    Find genes that share ontologies with KMT2C           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mll3):
     cellular  growth/size/body  mortality/aging  no phenotypic analysis  reproductive system 
     vision/eye 

    Find genes that share phenotypes with KMT2C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kmt2ctm1.1Jwle for KMT2C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KMT2C
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    miRNA
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    miRTarBase miRNAs that target KMT2C:
    hsa-mir-15b-5p (MIRT046443), hsa-mir-484 (MIRT041865), hsa-mir-652-3p (MIRT039471), hsa-mir-106b-3p (MIRT038581), hsa-mir-128-3p (MIRT021900), hsa-mir-26b-5p (MIRT028951), hsa-mir-615-3p (MIRT040134), hsa-mir-196a-5p (MIRT048165), hsa-mir-186-5p (MIRT045225), hsa-mir-335-5p (MIRT016990), hsa-mir-320a (MIRT044506), hsa-mir-940 (MIRT036615), hsa-mir-708-5p (MIRT037748)

    Block miRNA regulation of human, mouse, rat KMT2C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KMT2C
    SwitchGear 3'UTR luciferase reporter plasmidKMT2C 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat KMT2C

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KMT2C_HUMAN, Q8NEZ4: Nucleus (Probable)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17500065
    GO:0035097histone methyltransferase complex IDA17500065

    Find genes that share ontologies with KMT2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KMT2C About    
    See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation


    Find genes that share SuperPaths with KMT2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for KMT2C):
        Lysine degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KMT2C
    Interactions:

        Search GeneGlobe Interaction Network for KMT2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KMT2C (Q8NEZ41, 2, 3 ENSP000002621894) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3CQ71DI33, ENSP000003581544I2D: score=1 STRING: ENSP00000358154
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    NCOA6Q146861, 3, ENSP000003518944EBI-1042997,EBI-78670 I2D: score=1 STRING: ENSP00000351894
    H3F3AP842433, ENSP000003557784I2D: score=1 STRING: ENSP00000355778
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016571histone methylation ----
    GO:0035556intracellular signal transduction IEA--
    GO:0051568histone H3-K4 methylation IDA17500065

    Find genes that share ontologies with KMT2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KMT2C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KMT2C gene (2 alternative transcripts): 
    NM_170606.2  NM_021230.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360104(uc003wky.3) ENST00000558084 ENST00000262189(uc003wla.3)
    ENST00000424877 ENST00000473186 ENST00000485241 ENST00000418061 ENST00000558665
    ENST00000489110 ENST00000418673 ENST00000490130 ENST00000452749 ENST00000355193(uc003wkx.3 uc003wkz.3)
    ENST00000485655
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    Selected AceView cDNA sequences (see all 366):

    AA282356 BM127492 CA776966 AW999286 AL698915 AV723842 NM_170606 AA599219 
    AY024361 BE349960 BM713197 AA904721 AI214982 AI298476 AI079937 BQ890802 
    AW452981 AI915942 NM_021230 BU681728 BE674497 AK025911 AW864964 BM126876 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KMT2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KMT2C Expression
    About this image

    KMT2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KMT2C Protein Expression

    UniProtKB/Swiss-Prot: KMT2C_HUMAN, Q8NEZ4
    Tissue specificity: Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta,
    peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus,
    caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KMT2C gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mll35
    Kmt2c1
    myeloid/lymphoid or mixed-lineage leukemia 35
    lysine (K)-specific methyltransferase 2C1
    86.39(n)1
    85.58(a)1
      5 (12.35 cM)5
    2310511  NM_001081383.11  NP_001074852.11 
     252717985 
    chicken
    (Gallus gallus)
    Aves MLL31 myeloid/lymphoid or mixed-lineage leukemia 3 75.37(n)
    75.48(a)
      420437  XM_004939142.1  XP_004939199.1 
    lizard
    (Anolis carolinensis)
    Reptilia KMT2C6
    lysine (K)-specific methyltransferase 2C
    68(a)
    1 ↔ 1
    6(4259531-4402658)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119922 Transcribed sequence with strong similarity to protein more 84.21(n)    BX745905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.186112 Transcribed sequence with moderate similarity to protein more 73.12(n)    BQ449912.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lpt6
    Lost PHDs of trr
    32(a)
    many ↔ many
    2R(19786102-19791187)


    ENSEMBL Gene Tree for KMT2C (if available)
    TreeFam Gene Tree for KMT2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KMT2C gene
    KMT2D2  EZH12  SETD1B2  KMT2A2  SETD1A2  EZH22  ENSG000002723332  
    3 SIMAP similar genes for KMT2C using alignment to 8 protein entries:     KMT2C_HUMAN (see all proteins):
    DKFZp686C08112    MLL3    MLL2

    Find genes that share paralogs with KMT2C           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for KMT2C
    PGOHUM00000244981 PGOHUM00000250157 PGOHUM00000240175


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KMT2C (see all 9458)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363144
    A colorectal cancer sample4--see VAR_0363142 T S mis40--------
    VAR_0363134
    A colorectal cancer sample4--see VAR_0363132 L W mis40--------
    VAR_0363124
    A colorectal cancer sample4--see VAR_0363122 D N mis40--------
    VAR_0363114
    A colorectal cancer sample4--see VAR_0363112 C G mis40--------
    rs675135531,2
    C--145829124(+) ACCTGAGT/-TTCTC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1818215851,2
    --151831559(+) TTCTGA/GGCAGT 1 -- ds50010--------
    rs1854031441,2
    --151831576(+) CTTAAA/CCCCTT 1 -- ds50010--------
    rs1436785251,2
    --151831594(+) AATACA/GTTAAA 1 -- ds50010--------
    rs286443491,2
    C,F--151831673(+) AAAAAC/AAAAAA 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs44435771,2
    C--151831674(+) aaaaaA/Caaaaa 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KMT2C (151832010 - 152082010 bp, first 250kb of KMT2C)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KMT2C: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KMT2C
    DNA2.0 Custom Variant and Variant Library Synthesis for KMT2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606833    OMIM disorders: --

    1 disease for KMT2C:    
    About MalaCards
    leukemia


    Find genes that share disorders with KMT2C           About GenesLikeMe

    2 Novoseek inferred disease relationships for KMT2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 37.8 7 11718452 (2), 18082152 (1), 11891048 (1)
    cancer 0 1 11718452 (1)


    Export disorders for KMT2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KMT2C gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with KMT2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects. (PubMed id 11718452)1, 2, 9 Tan Y.C. and Chow V.T. (Cancer Detect. Prev. 2001)
    3. MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. (PubMed id 11891048)1, 2, 9 Ruault M.... De Sario A. (Gene 2002)
    4. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. (PubMed id 12482968)1, 2, 9 Goo Y.-H....Lee J.W. (Mol. Cell. Biol. 2003)
    5. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. (PubMed id 17500065)1, 2 Cho Y.-W.... Ge K. (J. Biol. Chem. 2007)
    6. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. (PubMed id 17021013)1, 2 Lee S.... Lee J.W. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    10. Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation. (PubMed id 19221051)1, 9 Lee S....Lee J.W. (Mol. Endocrinol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 58508 HGNC: 13726 AceView: MLL3 Ensembl:ENSG00000055609 euGenes: HUgn58508
    ECgene: KMT2C Kegg: 58508 H-InvDB: KMT2C

    (According to HUGE)
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    HUGE: KIAA1506

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KMT2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KMT2C gene:
    Search GeneIP for patents involving KMT2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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