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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KMT2B Gene

protein-coding   GIFtS: 40
GCID: GC19P036214

Lysine (K)-Specific Methyltransferase 2B

  Search for KMT2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysine (K)-Specific Methyltransferase 2B1 2     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog1
MLL42 3 5     KMT2D2
Lysine N-Methyltransferase 2B2 3     MLL1B2
Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 42 3     Histone-Lysine N-Methyltransferase 2B2
Trithorax Homolog 22 3     Histone-Lysine N-Methyltransferase MLL42
HRX22 3     Lysine N-Methyltransferase 2D2
MLL22 3     Mixed Lineage Leukemia Gene Homolog 22
TRX22 3     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila)
42
WBP-72 3     Myeloid/Lymphoid Or Mixed-Lineage Leukemia 42
WBP72 3     Trithorax Homologue 22
WW Domain-Binding Protein 72 3     WW Domain Binding Protein 72
KIAA03043 5     EC 2.1.1.433
Drosophila) 41     

External Ids:    HGNC: 158401   Entrez Gene: 97572   Ensembl: ENSG000001056637   OMIM: 6068345   UniProtKB: Q9UMN63   

Export aliases for KMT2B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KMT2B Gene:
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers,
two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET
domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family.
This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be
involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been
reported for this gene, however, the full length nature of the shorter transcript is not known. (provided by
RefSeq, Jul 2008)

GeneCards Summary for KMT2B Gene: 
KMT2B (lysine (K)-specific methyltransferase 2B) is a protein-coding gene.

UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6
Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription
regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth
and preimplantation development. Required during the transcriptionally active period of oocyte growth for the
establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that
preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation

Gene Wiki entry for KMT2B (MLL4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KMT2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKMT2B promoter sequence
   Search SABiosciences Chromatin IP Primers for KMT2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KMT2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

KMT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KMT2B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036214:  view genomic region     (about GC identifiers)

Start:
36,208,921 bp from pter      End:
36,229,779 bp from pter
Size:
20,859 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase 2B  
Size: 2715 amino acids; 293515 Da
Subunit: Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4,
ASH2L, RBBP5, WDR5, DPY30, MEN1; the complex interacts with POLR2A and POLR2B via MEN1. Interacts with NFE2.
Interacts with KDM6B
Subcellular location: Nucleus (By similarity)
Caution: This protein was first named MLL2 by PubMed:10637508 and PubMed:10409430. MLL2 corresponds to another
protein located on chromosome 12 (see AC O14686). Thus, KMT2B/MLL4 is often referred to as MLL2 and vice versa in
the literature
2 PDB 3D structures from and Proteopedia for KMT2B:
3UVM (3D)        4ERZ (3D)    
Secondary accessions: O15022 O95836 Q96GP2 Q96IP3 Q9UK25 Q9Y668 Q9Y669
Alternative splicing: 2 isoforms:  Q9UMN6-1   Q9UMN6-2   

Explore the universe of human proteins at neXtProt for KMT2B: NX_Q9UMN6

Explore proteomics data for KMT2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMN6

  • KMT2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KMT2B Protein Expression
    REFSEQ proteins: NP_055542.1  
    Human Recombinant Protein Products for KMT2B: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0035097histone methyltransferase complex IDA17500065

    KMT2B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    5/12 InterPro protein domains (see all 12):
     IPR017956 AT_hook_DNA-bd_motif
     IPR001214 SET_dom
     IPR003889 FYrich_C
     IPR016569 MeTrfase_trithorax
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UMN6

    ProtoNet protein and cluster: Q9UMN6

    5 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB001965 Zn-finger-like
    IPB002857 Zn-finger
    IPB003616 SET-related region
    IPB003888 FY-rich domain


    UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. TRX/MLL subfamily
    Similarity: Contains 3 A.T hook DNA-binding domains
    Similarity: Contains 1 CXXC-type zinc finger
    Similarity: Contains 1 FYR C-terminal domain
    Similarity: Contains 1 FYR N-terminal domain
    Similarity: Contains 3 PHD-type zinc fingers
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 SET domain


    KMT2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KMT2B_HUMAN, Q9UMN6
    Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
    specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription
    regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth
    and preimplantation development. Required during the transcriptionally active period of oocyte growth for the
    establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that
    preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10409430
    GO:0005515protein binding IPI17474147
    GO:0008270zinc ion binding NAS--
    GO:0042800histone methyltransferase activity (H3-K4 specific) IDA17500065
         
    KMT2B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KMT2B:
     Increased cell number in G2M,   Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Wbp7):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system  normal  reproductive system 

    KMT2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KMT2B: Kmt2btm1.2Afst Kmt2btm1Afst

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KMT2B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for KMT2B):
        Lysine degradation


    KMT2B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KMT2B

    5/35 Interacting proteins for KMT2B (Q9UMN61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271300 I2D: score=2 
    SMN2Q166372, 3MINT-8271300 I2D: score=2 
    ABL1P005192, 3MINT-8110539 I2D: score=3 
    ATXN1P542532, 3MINT-2867463 I2D: score=3 
    FYNP062412, 3MINT-8111367 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0009994oocyte differentiation IEA--
    GO:0016458gene silencing IEA--
    GO:0030728ovulation IEA--

    KMT2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KMT2B

    Search CenterWatch for drugs/clinical trials and news about KMT2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KMT2B gene: 
    NM_014727.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000606995 ENST00000607650 ENST00000592092 ENST00000585476 ENST00000586308

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    24/436 AceView cDNA sequences (see all 436):

    AA234185 CB118374 BE551179 CA412737 AL044104 AI002507 BU849201 BI029101 
    AI022687 Z39333 AL079384 AI219430 AJ007041 AF186605 BM930790 BF033854 
    BG152857 BU783750 BM750836 AA705561 BE549759 AI422717 AF105279 BM931357 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KMT2B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
    SP1:                    -                             -                                 
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                  -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for KMT2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KMT2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KMT2B Expression
    About this image


    See KMT2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KMT2B

    UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6
    Tissue specificity: Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle,
    kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas.
    Often amplified in pancreatic carcinomas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KMT2B gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wbp71 , 5 WW domain binding protein 71, 5 87.08(n)1
    91.31(a)1
      7 (18.63 cM)5
    754101  NM_029274.21  NP_083550.21 
     305688585 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343276.1(1486148-1523466)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.71922 Transcribed sequence with weak similarity to protein more 76.69(n)    AL859437.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mll4a6
    mll4b6
    myeloid/lymphoid or mixed-lineage leukemia 4b
    29(a)
    27(a)
    many → 1
    many → 1
    19(9855212-9897776)
    15(36155420-36242250)
    fruit fly
    (Drosophila melanogaster)
    Insecta trx6
    trithorax
    16(a)
    1 → many
    3R(10089080-10112623)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET16
    Histone methyltransferase, subunit of the COMPASS ...
    10(a)
    1 → many
    VIII(346043-349285)


    ENSEMBL Gene Tree for KMT2B (if available)
    TreeFam Gene Tree for KMT2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/721 SNPs in KMT2B are shown (see all 721)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22343701,2
    C,F--32711698(+) GCCCCG/ACACAG 1 -- us2k11Minor allele frequency- A:0.00NA 3312
    rs124630591,2
    C,A,H--36208449(+) GGTCCC/TGGGGC 1 -- us2k14Minor allele frequency- T:0.14NA EA 244
    rs1851683061,2
    --36208558(+) ACCCGA/GCAACC 1 -- us2k10--------
    rs1395023551,2
    C--36208566(+) CCCGC-/TTTTCC 1 -- us2k10--------
    rs775630371,2
    C--36208694(+) GACGC-/GGGGGT 1 -- us2k11Minor allele frequency- G:0.00CSA 2
    rs1897761761,2
    --36209073(+) GGCGGG/TGGCGC 2 G syn10--------
    rs1424864211,2
    --36209380(+) CGGGTC/TCTCAG 1 -- int10--------
    rs72477311,2
    C,F--36209680(+) CGCCCC/TGCCGG 1 -- int13Minor allele frequency- T:0.14WA EA 240
    rs340319111,2
    C,F--36209700(+) CCTCCT/GGGTTT 1 -- int15Minor allele frequency- G:0.14NA WA 244
    rs735905761,2
    C--36209781(+) AACAGG/TAGTGG 1 -- int13Minor allele frequency- T:0.12WA NA 240

    HapMap Linkage Disequilibrium report for KMT2B (36208921 - 36229779 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KMT2B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KMT2B
    DNA2.0 Custom Variant and Variant Library Synthesis for KMT2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KMT2B for disorders           About MalaCards
    OMIM gene information: 606834    OMIM disorders: --


    KMT2B for disorders           About GeneDecksing


    Export disorders for KMT2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KMT2B gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with KMT2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines. (PubMed id 10637508)1, 2, 3, 9 Huntsman D.G.... Caldas C. (1999)
    2. MLL2: a new mammalian member of the trx/MLL family of genes. (PubMed id 10409430)1, 2, 3 FitzGerald K.T. and Diaz M.O. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    6. Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. (PubMed id 23426673)1 Kerimoglu C....Fischer A. (2013)
    7. Structural basis for WDR5 interaction (Win) motif reco gnition in human SET1 family histone methyltransferases. (PubMed id 22665483)1 Dharmarajan V....Cosgrove M.S. (2012)
    8. Mixed lineage leukaemia-4 regulates cell-cycle progres sion and cell viability and its depletion suppresses growth of xenografted tumou r in vivo. (PubMed id 22713656)1 Ansari K.I....Mandal S.S. (2012)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. (PubMed id 23129768)1 Wang J....Hess J.L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9757 HGNC: 15840 AceView: MLL4andF25965andPEN2 Ensembl:ENSG00000105663 euGenes: HUgn9757
    ECgene: KMT2B Kegg: 9757 H-InvDB: KMT2B

    (According to HUGE)
    About This Section
    HUGE: KIAA0304

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KMT2B gene:
    Search GeneIP for patents involving KMT2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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