KMT2B Gene
protein-coding GIFtS: 40
GCID: GC19P036214
|
|
Lysine (K)-Specific Methyltransferase 2B
| |
Aliases
for KMT2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Lysine (K)-Specific Methyltransferase 2B1 2 | | Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog1 | | MLL42 3 5 | | KMT2D2 | | Lysine N-Methyltransferase 2B2 3 | | MLL1B2 | | Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 42 3 | | Histone-Lysine N-Methyltransferase 2B2 | | Trithorax Homolog 22 3 | | Histone-Lysine N-Methyltransferase MLL42 | | HRX22 3 | | Lysine N-Methyltransferase 2D2 | | MLL22 3 | | Mixed Lineage Leukemia Gene Homolog 22 | | TRX22 3 | | Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila)
42 | | WBP-72 3 | | Myeloid/Lymphoid Or Mixed-Lineage Leukemia 42 | | WBP72 3 | | Trithorax Homologue 22 | | WW Domain-Binding Protein 72 3 | | WW Domain Binding Protein 72 | | KIAA03043 5 | | EC 2.1.1.433 | | Drosophila) 41 | | |
Export aliases for KMT2B gene to outside databases |
Summaries
for KMT2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KMT2B Gene:
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers,
two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET
domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family.
This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be
involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been
reported for this gene, however, the full length nature of the shorter transcript is not known. (provided by
RefSeq, Jul 2008)
GeneCards Summary for KMT2B Gene: 
KMT2B (lysine (K)-specific methyltransferase 2B) is a protein-coding gene.
UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription
regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth
and preimplantation development. Required during the transcriptionally active period of oocyte growth for the
establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that
preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation
Gene Wiki entry for KMT2B (MLL4) Gene
|
Genomic Views
for KMT2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KMT2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for KMT2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KMT2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1KMT2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P036214: view genomic region
(about GC identifiers)
Start:
|
36,208,921 bp from pter |
End:
|
36,229,779 bp from pter |
Size:
|
20,859 bases |
Orientation:
|
plus strand |
|
Proteins
for KMT2B gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6 (See
protein sequence)Recommended Name: Histone-lysine N-methyltransferase 2B Size: 2715 amino acids; 293515 Da
Subunit: Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4,
ASH2L, RBBP5, WDR5, DPY30, MEN1; the complex interacts with POLR2A and POLR2B via MEN1. Interacts with NFE2.
Interacts with KDM6B
Subcellular location: Nucleus (By similarity)
Caution: This protein was first named MLL2 by PubMed:10637508 and PubMed:10409430. MLL2 corresponds to another
protein located on chromosome 12 (see AC O14686). Thus, KMT2B/MLL4 is often referred to as MLL2 and vice versa in
the literature
2 PDB 3D structures from  and Proteopedia  for KMT2B:3UVM (3D)
4ERZ (3D)
Secondary accessions: O15022 O95836 Q96GP2 Q96IP3 Q9UK25 Q9Y668 Q9Y669Alternative splicing: 2 isoforms: Q9UMN6-1 Q9UMN6-2 Explore the universe of human proteins at neXtProt for KMT2B: NX_Q9UMN6
Explore proteomics data for KMT2B at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q9UMN6
KMT2B Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_055542.1
Human Recombinant Protein Products for KMT2B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KMT2B for ontologies About GeneDecksing
KMT2B Antibody Products:
Assay Products for KMT2B: |
Protein
Domains /
Families
for KMT2B gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
KMT: Chromatin-modifying enzymes / K-methyltransferases
5/12 InterPro protein domains (see all 12):Graphical View of Domain Structure for InterPro Entry Q9UMN6ProtoNet protein and cluster: Q9UMN6 5 Blocks protein domains: IPB001214 Nuclear protein SET IPB001965 Zn-finger-like IPB002857 Zn-finger IPB003616 SET-related region IPB003888 FY-rich domain
UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
methyltransferase family. TRX/MLL subfamilySimilarity: Contains 3 A.T hook DNA-binding domainsSimilarity: Contains 1 CXXC-type zinc fingerSimilarity: Contains 1 FYR C-terminal domainSimilarity: Contains 1 FYR N-terminal domainSimilarity: Contains 3 PHD-type zinc fingersSimilarity: Contains 1 post-SET domainSimilarity: Contains 1 SET domain
KMT2B for domains About GeneDecksing
|
Function
for KMT2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KMT2B_HUMAN, Q9UMN6Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription
regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth
and preimplantation development. Required during the transcriptionally active period of oocyte growth for the
establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that
preceeds resumption of meiosis, oocyte survival and normal zygotic genome activationCatalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
N(6)-methyl-L-lysine-[histone] Enzyme Number (IUBMB): EC 2.1.1.431
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
KMT2B for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for KMT2B:
9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Wbp7):
KMT2B for phenotypes About GeneDecksing
Animal Models:
MGI mouse knock-outs for KMT2B: Kmt2btm1.2Afst Kmt2btm1Afst
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for KMT2B | |  | Search LifeMap BioReagents cell lines for KMT2B | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2B |
Pathways & Interactions
for KMT2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
SuperPaths for KMT2B About See pathways by source
| SuperPath | Contained pathways About |
|---|
| 1 | Lysine degradation | |
Pathways by source See SuperPaths
Show all pathways
1 
Kegg Pathway (Kegg details for KMT2B):
KMT2B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KMT2B
5/35 Interacting proteins for KMT2B (Q9UMN61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 35)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
KMT2B for ontologies About GeneDecksing
|
Drugs & Compounds
for KMT2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KMT2B
Search CenterWatch for drugs/clinical trials and news about KMT2B
|
Transcripts
for KMT2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KMT2B gene: NM_014727.1 5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000606995 ENST00000607650 ENST00000592092 ENST00000585476 ENST00000586308
24/436 AceView cDNA sequences (see all 436): AA234185 CB118374 BE551179 CA412737 AL044104 AI002507 BU849201 BI029101 AI022687 Z39333 AL079384 AI219430 AJ007041 AF186605 BM930790 BF033854 BG152857 BU783750 BM750836 AA705561 BE549759 AI422717 AF105279 BM931357
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KMT2B (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KMT2B
|
Expression
for KMT2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KMT2B expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image
See KMT2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KMT2B
UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6Tissue specificity: Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle,
kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas.
Often amplified in pancreatic carcinomas
SABiosciences Custom PCR Arrays for KMT2B
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for KMT2B
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat KMT2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KMT2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KMT2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2B |
Orthologs
for KMT2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for KMT2B gene from 6/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Wbp71 , 5 |
WW domain binding protein 71, 5 |
87.08(n)1
91.31(a)1 |
|
7 (18.63 cM)5
754101 NM_029274.21 NP_083550.21
305688585 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
Uncharacterized protein |
55(a) |
1 ↔ 1 |
GL343276.1(1486148-1523466) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.71922 |
Transcribed sequence with weak similarity to protein more |
76.69(n) |
|
AL859437.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
mll4a6mll4b6 |
myeloid/lymphoid or mixed-lineage leukemia 4b |
29(a)27(a) |
many → 1many → 1 |
19(9855212-9897776) 15(36155420-36242250) |
fruit fly
(Drosophila melanogaster) |
Insecta |
trx6 |
trithorax |
16(a) |
1 → many |
3R(10089080-10112623) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SET16 |
Histone methyltransferase, subunit of the COMPASS ... |
10(a) |
1 → many |
VIII(346043-349285) |
ENSEMBL Gene Tree for KMT2B (if available)
TreeFam Gene Tree for KMT2B (if available) |
Paralogs
for KMT2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KMT2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KMT2B (36208921 - 36229779 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for KMT2B: --
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KMT2B |
|
Disorders
/ Diseases
for KMT2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KMT2B for disorders About MalaCards
OMIM gene information: 606834
OMIM disorders: --
KMT2B for disorders About GeneDecksing
Export disorders for KMT2B gene to outside databases
|
Publications
for KMT2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KMT2B gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with KMT2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines. (PubMed id 10637508)1, 2, 3, 9 Huntsman D.G.... Caldas C. (1999)
- MLL2: a new mammalian member of the trx/MLL family of genes. (PubMed id 10409430)1, 2, 3 FitzGerald K.T. and Diaz M.O. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
- Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. (PubMed id 23426673)1 Kerimoglu C....Fischer A. (2013)
- Structural basis for WDR5 interaction (Win) motif reco gnition in human SET1 family histone methyltransferases. (PubMed id 22665483)1 Dharmarajan V....Cosgrove M.S. (2012)
- Mixed lineage leukaemia-4 regulates cell-cycle progres sion and cell viability and its depletion suppresses growth of xenografted tumou r in vivo. (PubMed id 22713656)1 Ansari K.I....Mandal S.S. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. (PubMed id 23129768)1 Wang J....Hess J.L. (2012)
|
External Searches for KMT2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KMT2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KMT2B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KMT2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KMT2B gene:
Search GeneIP for patents involving KMT2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KMT2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KMT2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KMT2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KMT2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KMT2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KMT2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KMT2B |
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| | | | Search Tocris compounds for KMT2B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2B |
|  |  |  |  | | | | ThermoFisher Antibodies for KMT2B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KMT2B |
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GeneCards Homepage -
Last full update: 23 Oct 2013 -
Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014
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