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KMT2B Gene

protein-coding GIFtS: 41
GCID: GC19P036217

Lysine (K)-Specific Methyltransferase 2B

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Lysine (K)-Specific Methyltransferase 2B¹ ²		Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog¹
MLL4² ³ ⁵		KMT2D²
Lysine N-Methyltransferase 2B² ³		MLL1B²
Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 4² ³		Histone-Lysine N-Methyltransferase 2B²
Trithorax Homolog 2² ³		Histone-Lysine N-Methyltransferase MLL4²
HRX2² ³		Lysine N-Methyltransferase 2D²
MLL2² ³		Mixed Lineage Leukemia Gene Homolog 2²
TRX2² ³		Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 4²
WBP-7² ³		Myeloid/Lymphoid Or Mixed-Lineage Leukemia 4²
WBP7² ³		Trithorax Homologue 2²
WW Domain-Binding Protein 7² ³		WW Domain Binding Protein 7²
KIAA0304³ ⁵		EC 2.1.1.43³
Drosophila) 4¹

External Ids:	HGNC: 15840¹	Entrez Gene: 9757²	Ensembl: ENSG00000105663⁷	OMIM: 606834⁵	UniProtKB: Q9UMN6³

Export aliases for KMT2B gene to outside databases

Previous GC identifer: GC19P036214

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KMT2B Gene:

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers,

two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET

domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family.

This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be

involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been

reported for this gene, however, the full length nature of the shorter transcript is not known. (provided by

RefSeq, Jul 2008)

GeneCards Summary for KMT2B Gene:

KMT2B (lysine (K)-specific methyltransferase 2B) is a protein-coding gene. Diseases associated with KMT2B include leukemia, and ataxia. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6

Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a

specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription

regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth

and preimplantation development. Required during the transcriptionally active period of oocyte growth for the

establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that

preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation

Gene Wiki entry for KMT2B (MLL4) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Search for regulatory transcription factor binding sites for KMT2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KMT2B promoter sequence

Search Chromatin IP Primers for KMT2B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KMT2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1

KMT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KMT2B gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P036217: view genomic region (about GC identifiers)

Start:	36,208,921 bp from pter	End:	36,229,779 bp from pter
Size:	20,859 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6 (See protein sequence)

Recommended Name: Histone-lysine N-methyltransferase 2B

Size: 2715 amino acids; 293515 Da

Subunit: Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4,

ASH2L, RBBP5, WDR5, DPY30, MEN1; the complex interacts with POLR2A and POLR2B via MEN1. Interacts with NFE2.

Interacts with KDM6B

Caution: This protein was first named MLL2 by PubMed:10637508 and PubMed:10409430. MLL2 corresponds to another

protein located on chromosome 12 (see AC O14686). Thus, KMT2B/MLL4 is often referred to as MLL2 and vice versa in

the literature

2 PDB 3D structures from and Proteopedia for KMT2B:

3UVM (3D)

4ERZ (3D)

Secondary accessions: O15022 O95836 Q96GP2 Q96IP3 Q9UK25 Q9Y668 Q9Y669

Alternative splicing: 2 isoforms: Q9UMN6-1 Q9UMN6-2

Explore the universe of human proteins at neXtProt for KMT2B: NX_Q9UMN6

Explore proteomics data for KMT2B at MOPED

Post-translational modifications:

Ubiquitination² at Lys2196

Modification sites at PhosphoSitePlus

See KMT2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055542.1

KMT2B Human Recombinant Protein Products:

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KMT2B Antibody Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

KMT: Chromatin-modifying enzymes / K-methyltransferases

Selected InterPro protein domains (see all 11):

IPR017956 AT_hook_DNA-bd_motif

IPR001214 SET_dom

IPR003889 FYrich_C

IPR016569 MeTrfase_trithorax

IPR001965 Znf_PHD

Graphical View of Domain Structure for InterPro Entry Q9UMN6

ProtoNet protein and cluster: Q9UMN6

5 Blocks protein domains:

IPB001214 Nuclear protein SET

IPB001965 Zn-finger-like

IPB002857 Zn-finger

IPB003616 SET-related region

IPB003888 FY-rich domain

UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6

Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine

methyltransferase family. TRX/MLL subfamily

Similarity: Contains 3 A.T hook DNA-binding domains

Similarity: Contains 1 CXXC-type zinc finger

Similarity: Contains 1 FYR C-terminal domain

Similarity: Contains 1 FYR N-terminal domain

Similarity: Contains 3 PHD-type zinc fingers

Similarity: Contains 1 post-SET domain

Similarity: Contains 1 SET domain

KMT2B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: KMT2B_HUMAN, Q9UMN6

Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a

specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription

regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth

and preimplantation development. Required during the transcriptionally active period of oocyte growth for the

establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that

preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +

N(6)-methyl-L-lysine-[histone]

Enzyme Number (IUBMB): EC 2.1.1.43¹

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	10409430
GO:0005515	protein binding	IPI	17474147
GO:0008270	zinc ion binding	IEA	--
GO:0042800	histone methyltransferase activity (H3-K4 specific)	IDA	17500065

KMT2B for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for KMT2B:

Increased cell number in G2M,

Increased gamma-H2AX phosphory

13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Wbp7):

adipose tissue	cardiovascular system	cellular	craniofacial	embryogenesis
endocrine/exocrine gland	growth/size/body	homeostasis/metabolism	liver/biliary system	mortality/aging
nervous system	normal	reproductive system

KMT2B for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for KMT2B: Kmt2b^tm1.2Afst Kmt2b^tm1Afst

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KMT2B

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KMT2B

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KMT2B

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KMT2B

miRNA Products:		miRTarBase miRNAs that target KMT2B: hsa-mir-92b-3p (MIRT040527), hsa-mir-186-5p (MIRT021140), hsa-mir-877-5p (MIRT037311), hsa-mir-93-5p (MIRT028093), hsa-mir-9-5p (MIRT021394), hsa-mir-760 (MIRT036755), hsa-mir-320a (MIRT044425), hsa-mir-766-3p (MIRT039045), hsa-mir-222-3p (MIRT046827), hsa-mir-92a-3p (MIRT049163), hsa-mir-196b-5p (MIRT042681), hsa-mir-615-3p (MIRT039869), hsa-mir-1229-3p (MIRT036326), hsa-mir-1224-3p (MIRT036547), hsa-mir-34a-5p (MIRT025558), hsa-mir-130b-3p (MIRT020244), hsa-mir-744-5p (MIRT037627), hsa-mir-125b-5p (MIRT045979), hsa-mir-15b-5p (MIRT046526), hsa-mir-27a-3p (MIRT050025), hsa-mir-106b-5p (MIRT044297), hsa-mir-30c-5p (MIRT047911), hsa-mir-18a-3p (MIRT040931)

		Block miRNA regulation of human, mouse, rat KMT2B using miScript Target Protectors
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2B

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

KMT2B_HUMAN, Q9UMN6: Nucleus (By similarity)

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17500065
GO:0035097	histone methyltransferase complex	IDA	17500065

KMT2B for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KMT2B About

See pathways by source

SuperPath

Contained pathways About

Lysine degradation

Lysine degradation

Pathways by source See SuperPaths
Show all pathways

1 Kegg Pathway (Kegg details for KMT2B):

Lysine degradation

KMT2B for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for KMT2B
Interactions:

Search GeneGlobe Interaction Network for KMT2B

Selected Interacting proteins for KMT2B (Q9UMN6^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³	MINT-8271300 I2D: score=2
SMN2	Q16637²^,³	MINT-8271300 I2D: score=2
ABL1	P00519²^,³	MINT-8110539 I2D: score=3
ATXN1	P54253²^,³	MINT-2867463 I2D: score=3
FYN	P06241²^,³	MINT-8111367 I2D: score=3

About this table

Gene Ontology (GO): Selected biological process terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001541	ovarian follicle development	IEA	--
GO:0006351	transcription, DNA-templated	IEA	--
GO:0009994	oocyte differentiation	IEA	--
GO:0016458	gene silencing	IEA	--
GO:0030728	ovulation	IEA	--

KMT2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for KMT2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KMT2B gene:

NM_014727.1

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000606995(processed_transcript) ENST00000607650(processed_transcript) ENST00000592092(processed_transcript) ENST00000585476(processed_transcript) ENST00000586308(processed_transcript)

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Selected AceView cDNA sequences (see all 436):

F06418 BQ000296 CF124998 AB002302 CA312649 AA729144 AA324160 BE551179

AJ007041 BM930790 BC026861 AI804348 BU688310 BQ717496 BU783750 CA412737

BM793550 AV682591 AW204883 AI422717 CA433512 AI219430 CB118374 BM853552

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for KMT2B (see all 10) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	22b	^	23	^	24	^	25a	·	25b	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30	^	31a	·	31b
SP1:							-										-
SP2:
SP3:
SP4:																	-
SP5:

ECgene alternative splicing isoforms for KMT2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KMT2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

KMT2B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

KMT2B Protein Expression

UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6

Tissue specificity: Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle,

kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas.

Often amplified in pancreatic carcinomas

Custom PCR Arrays for KMT2B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for KMT2B gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wbp7⁵ Kmt2b¹	WW domain binding protein 7⁵ lysine (K)-specific methyltransferase 2B¹	85.92(n)¹ 89.5(a)¹		7 (18.63 cM)⁵ 75410¹ NM_029274.2¹ NP_083550.2¹ 30568858⁵
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.7192²	Transcribed sequence with weak similarity to protein more	76.69(n)		AL859437.2

ENSEMBL Gene Tree for KMT2B (if available)
TreeFam Gene Tree for KMT2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2234370^1,2	C,F	--	32711698(+)	`GCCCCG/ACACAG`	1	--	us2k¹		1		NA	3312
rs12463059^1,2	C,A,H	--	36208449(+)	`GGTCCC/TGGGGC`	1	--	us2k¹		4		NA EA	244
rs185168306^1,2		--	36208558(+)	`ACCCGA/GCAACC`	1	--	us2k¹		0	--	--	--	--
rs139502355^1,2	C	--	36208566(+)	`CCCGC-/TTTTCC`	1	--	us2k¹		0	--	--	--	--
rs77563037^1,2	C	--	36208694(+)	`GACGC-/GGGGGT`	1	--	us2k¹		1		CSA	2
rs189776176^1,2		--	36209073(+)	`GGCGGG/TGGCGC`	2	G	syn¹		0	--	--	--	--
rs142486421^1,2		--	36209380(+)	`CGGGTC/TCTCAG`	1	--	int¹		0	--	--	--	--
rs7247731^1,2	C,F	--	36209680(+)	`CGCCCC/TGCCGG`	1	--	int¹		3		WA EA	240
rs34031911^1,2	C,F	--	36209700(+)	`CCTCCT/GGGTTT`	1	--	int¹		5		NA WA	244
rs73590576^1,2	C	--	36209781(+)	`AACAGG/TAGTGG`	1	--	int¹		3		WA NA	240

HapMap Linkage Disequilibrium report for KMT2B (36208921 - 36229779 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for KMT2B: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KMT2B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606834 OMIM disorders: --

7 diseases for KMT2B:
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leukemia ataxia hepatitis b hepatocellular carcinoma

pancreatitis hepatitis prostatitis

KMT2B for disorders About GeneDecksing

Export disorders for KMT2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KMT2B gene, integrated from 10 sources (see all 47):
(articles sorted by number of sources associating them with KMT2B)

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world of online information

MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines. (PubMed id 10637508)^{1, 2, 3, 9} Huntsman D.G.... Caldas C. (Oncogene 1999)
MLL2: a new mammalian member of the trx/MLL family of genes. (PubMed id 10409430)^{1, 2, 3} FitzGerald K.T. and Diaz M.O. (Genomics 1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (Nature 2004)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1997)
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. (PubMed id 24081332)¹ Hu D....Shilatifard A. (Mol. Cell. Biol. 2013)
Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. (PubMed id 23426673)¹ Kerimoglu C....Fischer A. (J. Neurosci. 2013)
Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. (PubMed id 22665483)¹ Dharmarajan V....Cosgrove M.S. (J. Biol. Chem. 2012)
Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo. (PubMed id 22713656)¹ Ansari K.I....Mandal S.S. (Br. J. Cancer 2012)
A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. (PubMed id 23129768)¹ Wang J....Hess J.L. (J. Biol. Chem. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9757	HGNC: 15840	AceView: MLL4andF25965andPEN2	Ensembl:ENSG00000105663	euGenes: HUgn9757
ECgene: KMT2B	Kegg: 9757	H-InvDB: KMT2B

(According to HUGE)
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HUGE: KIAA0304

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Intellectual Property for KMT2B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KMT2B gene:
Search GeneIP for patents involving KMT2B

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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KMT2B Gene

Lysine (K)-Specific Methyltransferase 2B

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KMT2B (Gene Symbol)
Lysine (K)-Specific Methyltransferase 2B
MLL4
Lysine N-Methyltransferase 2B
Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 4
Trithorax Homolog 2
HRX2
MLL2
TRX2
WBP-7
WBP7
WW Domain-Binding Protein 7
KIAA0304
Drosophila) 4
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog
KMT2D
MLL1B
Histone-Lysine N-Methyltransferase 2B
Histone-Lysine N-Methyltransferase MLL4
Lysine N-Methyltransferase 2D
Mixed Lineage Leukemia Gene Homolog 2
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 4
Myeloid/Lymphoid Or Mixed-Lineage Leukemia 4
Trithorax Homologue 2
WW Domain Binding Protein 7
EC 2.1.1.43

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KMT2B Gene

Lysine (K)-Specific Methyltransferase 2B

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