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KMT2B Gene

protein-coding   GIFtS: 41
GCID: GC19P036217

Lysine (K)-Specific Methyltransferase 2B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysine (K)-Specific Methyltransferase 2B1 2     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog1
MLL42 3 5     KMT2D2
Lysine N-Methyltransferase 2B2 3     MLL1B2
Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 42 3     Histone-Lysine N-Methyltransferase 2B2
Trithorax Homolog 22 3     Histone-Lysine N-Methyltransferase MLL42
HRX22 3     Lysine N-Methyltransferase 2D2
MLL22 3     Mixed Lineage Leukemia Gene Homolog 22
TRX22 3     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila)
42
WBP-72 3     Myeloid/Lymphoid Or Mixed-Lineage Leukemia 42
WBP72 3     Trithorax Homologue 22
WW Domain-Binding Protein 72 3     WW Domain Binding Protein 72
KIAA03043 5     EC 2.1.1.433
Drosophila) 41     

External Ids:    HGNC: 158401   Entrez Gene: 97572   Ensembl: ENSG000001056637   OMIM: 6068345   UniProtKB: Q9UMN63   

Export aliases for KMT2B gene to outside databases

Previous GC identifer: GC19P036214


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KMT2B Gene:
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers,
two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET
domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family.
This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be
involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been
reported for this gene, however, the full length nature of the shorter transcript is not known. (provided by
RefSeq, Jul 2008)

GeneCards Summary for KMT2B Gene:
KMT2B (lysine (K)-specific methyltransferase 2B) is a protein-coding gene. Diseases associated with KMT2B include leukemia, and ataxia. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6
Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription
regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth
and preimplantation development. Required during the transcriptionally active period of oocyte growth for the
establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that
preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation

Gene Wiki entry for KMT2B (MLL4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for KMT2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKMT2B promoter sequence
   Search Chromatin IP Primers for KMT2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KMT2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

KMT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KMT2B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036217:  view genomic region     (about GC identifiers)

Start:
36,208,921 bp from pter      End:
36,229,779 bp from pter
Size:
20,859 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase 2B  
Size: 2715 amino acids; 293515 Da
Subunit: Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4,
ASH2L, RBBP5, WDR5, DPY30, MEN1; the complex interacts with POLR2A and POLR2B via MEN1. Interacts with NFE2.
Interacts with KDM6B
Caution: This protein was first named MLL2 by PubMed:10637508 and PubMed:10409430. MLL2 corresponds to another
protein located on chromosome 12 (see AC O14686). Thus, KMT2B/MLL4 is often referred to as MLL2 and vice versa in
the literature
2 PDB 3D structures from and Proteopedia for KMT2B:
3UVM (3D)        4ERZ (3D)    
Secondary accessions: O15022 O95836 Q96GP2 Q96IP3 Q9UK25 Q9Y668 Q9Y669
Alternative splicing: 2 isoforms:  Q9UMN6-1   Q9UMN6-2   

Explore the universe of human proteins at neXtProt for KMT2B: NX_Q9UMN6

Explore proteomics data for KMT2B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys2196
  • Modification sites at PhosphoSitePlus

  • See KMT2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055542.1  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    Selected InterPro protein domains (see all 11):
     IPR017956 AT_hook_DNA-bd_motif
     IPR001214 SET_dom
     IPR003889 FYrich_C
     IPR016569 MeTrfase_trithorax
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UMN6

    ProtoNet protein and cluster: Q9UMN6

    5 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB001965 Zn-finger-like
    IPB002857 Zn-finger
    IPB003616 SET-related region
    IPB003888 FY-rich domain


    UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. TRX/MLL subfamily
    Similarity: Contains 3 A.T hook DNA-binding domains
    Similarity: Contains 1 CXXC-type zinc finger
    Similarity: Contains 1 FYR C-terminal domain
    Similarity: Contains 1 FYR N-terminal domain
    Similarity: Contains 3 PHD-type zinc fingers
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 SET domain


    KMT2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KMT2B_HUMAN, Q9UMN6
    Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a
    specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription
    regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth
    and preimplantation development. Required during the transcriptionally active period of oocyte growth for the
    establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that
    preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10409430
    GO:0005515protein binding IPI17474147
    GO:0008270zinc ion binding IEA--
    GO:0042800histone methyltransferase activity (H3-K4 specific) IDA17500065
         
    KMT2B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KMT2B:
     Increased cell number in G2M,   Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Wbp7):
     adipose tissue  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  liver/biliary system  mortality/aging 
     nervous system  normal  reproductive system 

    KMT2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KMT2B: Kmt2btm1.2Afst Kmt2btm1Afst

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    miRTarBase miRNAs that target KMT2B:
    hsa-mir-92b-3p (MIRT040527), hsa-mir-186-5p (MIRT021140), hsa-mir-877-5p (MIRT037311), hsa-mir-93-5p (MIRT028093), hsa-mir-9-5p (MIRT021394), hsa-mir-760 (MIRT036755), hsa-mir-320a (MIRT044425), hsa-mir-766-3p (MIRT039045), hsa-mir-222-3p (MIRT046827), hsa-mir-92a-3p (MIRT049163), hsa-mir-196b-5p (MIRT042681), hsa-mir-615-3p (MIRT039869), hsa-mir-1229-3p (MIRT036326), hsa-mir-1224-3p (MIRT036547), hsa-mir-34a-5p (MIRT025558), hsa-mir-130b-3p (MIRT020244), hsa-mir-744-5p (MIRT037627), hsa-mir-125b-5p (MIRT045979), hsa-mir-15b-5p (MIRT046526), hsa-mir-27a-3p (MIRT050025), hsa-mir-106b-5p (MIRT044297), hsa-mir-30c-5p (MIRT047911), hsa-mir-18a-3p (MIRT040931)

    Block miRNA regulation of human, mouse, rat KMT2B using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KMT2B_HUMAN, Q9UMN6: Nucleus (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17500065
    GO:0035097histone methyltransferase complex IDA17500065

    KMT2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KMT2B About    
    See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for KMT2B):
        Lysine degradation


    KMT2B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KMT2B
    Interactions:

        Search GeneGlobe Interaction Network for KMT2B

    Selected Interacting proteins for KMT2B (Q9UMN61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271300 I2D: score=2 
    SMN2Q166372, 3MINT-8271300 I2D: score=2 
    ABL1P005192, 3MINT-8110539 I2D: score=3 
    ATXN1P542532, 3MINT-2867463 I2D: score=3 
    FYNP062412, 3MINT-8111367 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0009994oocyte differentiation IEA--
    GO:0016458gene silencing IEA--
    GO:0030728ovulation IEA--

    KMT2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KMT2B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KMT2B gene: 
    NM_014727.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000606995(processed_transcript) ENST00000607650(processed_transcript) ENST00000592092(processed_transcript) ENST00000585476(processed_transcript) ENST00000586308(processed_transcript)

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    Selected AceView cDNA sequences (see all 436):

    F06418 BQ000296 CF124998 AB002302 CA312649 AA729144 AA324160 BE551179 
    AJ007041 BM930790 BC026861 AI804348 BU688310 BQ717496 BU783750 CA412737 
    BM793550 AV682591 AW204883 AI422717 CA433512 AI219430 CB118374 BM853552 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KMT2B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
    SP1:                    -                             -                                 
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                  -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for KMT2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KMT2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KMT2B Expression
    About this image

    KMT2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KMT2B Protein Expression

    UniProtKB/Swiss-Prot: KMT2B_HUMAN, Q9UMN6
    Tissue specificity: Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle,
    kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas.
    Often amplified in pancreatic carcinomas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KMT2B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wbp75
    Kmt2b1
    WW domain binding protein 75
    lysine (K)-specific methyltransferase 2B1
    85.92(n)1
    89.5(a)1
      7 (18.63 cM)5
    754101  NM_029274.21  NP_083550.21 
     305688585 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.71922 Transcribed sequence with weak similarity to protein more 76.69(n)    AL859437.2 


    ENSEMBL Gene Tree for KMT2B (if available)
    TreeFam Gene Tree for KMT2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KMT2B (see all 721)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22343701,2
    C,F--32711698(+) GCCCCG/ACACAG 1 -- us2k11Minor allele frequency- A:0.00NA 3312
    rs124630591,2
    C,A,H--36208449(+) GGTCCC/TGGGGC 1 -- us2k14Minor allele frequency- T:0.14NA EA 244
    rs1851683061,2
    --36208558(+) ACCCGA/GCAACC 1 -- us2k10--------
    rs1395023551,2
    C--36208566(+) CCCGC-/TTTTCC 1 -- us2k10--------
    rs775630371,2
    C--36208694(+) GACGC-/GGGGGT 1 -- us2k11Minor allele frequency- G:0.00CSA 2
    rs1897761761,2
    --36209073(+) GGCGGG/TGGCGC 2 G syn10--------
    rs1424864211,2
    --36209380(+) CGGGTC/TCTCAG 1 -- int10--------
    rs72477311,2
    C,F--36209680(+) CGCCCC/TGCCGG 1 -- int13Minor allele frequency- T:0.14WA EA 240
    rs340319111,2
    C,F--36209700(+) CCTCCT/GGGTTT 1 -- int15Minor allele frequency- G:0.14NA WA 244
    rs735905761,2
    C--36209781(+) AACAGG/TAGTGG 1 -- int13Minor allele frequency- T:0.12WA NA 240

    HapMap Linkage Disequilibrium report for KMT2B (36208921 - 36229779 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KMT2B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KMT2B
    DNA2.0 Custom Variant and Variant Library Synthesis for KMT2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606834    OMIM disorders: --

    7 diseases for KMT2B:    
    About MalaCards
    leukemia    ataxia    hepatitis b    hepatocellular carcinoma
    pancreatitis    hepatitis    prostatitis


    KMT2B for disorders           About GeneDecksing


    Export disorders for KMT2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KMT2B gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with KMT2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines. (PubMed id 10637508)1, 2, 3, 9 Huntsman D.G.... Caldas C. (Oncogene 1999)
    2. MLL2: a new mammalian member of the trx/MLL family of genes. (PubMed id 10409430)1, 2, 3 FitzGerald K.T. and Diaz M.O. (Genomics 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    6. The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. (PubMed id 24081332)1 Hu D....Shilatifard A. (Mol. Cell. Biol. 2013)
    7. Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. (PubMed id 23426673)1 Kerimoglu C....Fischer A. (J. Neurosci. 2013)
    8. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. (PubMed id 22665483)1 Dharmarajan V....Cosgrove M.S. (J. Biol. Chem. 2012)
    9. Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo. (PubMed id 22713656)1 Ansari K.I....Mandal S.S. (Br. J. Cancer 2012)
    10. A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. (PubMed id 23129768)1 Wang J....Hess J.L. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9757 HGNC: 15840 AceView: MLL4andF25965andPEN2 Ensembl:ENSG00000105663 euGenes: HUgn9757
    ECgene: KMT2B Kegg: 9757 H-InvDB: KMT2B

    (According to HUGE)
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    HUGE: KIAA0304

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KMT2B gene:
    Search GeneIP for patents involving KMT2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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