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Aliases for KMT2A Gene

Aliases for KMT2A Gene

  • Lysine (K)-Specific Methyltransferase 2A 2 3
  • MLL 3 4 6
  • HRX 3 4 6
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 2 3
  • CXXC-Type Zinc Finger Protein 7 3 4
  • Lysine N-Methyltransferase 2A 3 4
  • Zinc Finger Protein HRX 3 4
  • Trithorax-Like Protein 3 4
  • HTRX1 3 6
  • WDSTS 3 6
  • ALL-1 3 4
  • CXXC7 3 4
  • MLL1 3 4
  • TRX1 3 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog) 2
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 1 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia 4
  • Histone-Lysine N-Methyltransferase 2A 3
  • MLL-AF4 Der(11) Fusion Protein 3
  • Mixed Lineage Leukemia 1 3
  • MLL/GAS7 Fusion Protein 3
  • CDK6/MLL Fusion Protein 3
  • MLL/GMPS Fusion Protein 3
  • EC 2.1.1.43 4
  • MLL/GAS7 3
  • TET1-MLL 3
  • MLL1A 3
  • ALL1 4
  • HTRX 4

External Ids for KMT2A Gene

Previous HGNC Symbols for KMT2A Gene

  • MLL

Previous GeneCards Identifiers for KMT2A Gene

  • GC11P118311
  • GC11P118313

Summaries for KMT2A Gene

Entrez Gene Summary for KMT2A Gene

  • This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

GeneCards Summary for KMT2A Gene

KMT2A (Lysine (K)-Specific Methyltransferase 2A) is a Protein Coding gene. Diseases associated with KMT2A include wiedemann-steiner syndrome and acute biphenotypic leukemia. Among its related pathways are Transcriptional misregulation in cancer and Senescence and Autophagy. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is KMT2C.

UniProtKB/Swiss-Prot for KMT2A Gene

  • Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of Lys-4 of histone H3 (H3K4me) complex and acetylation of Lys-16 of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, while it has higher activity toward H3 acetylated on Lys-9. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of Lys-4 of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity).

Gene Wiki entry for KMT2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KMT2A Gene

Genomics for KMT2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KMT2A Gene

Start:
118,436,490 bp from pter
End:
118,526,832 bp from pter
Size:
90,343 bases
Orientation:
Plus strand

Genomic View for KMT2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KMT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KMT2A Gene

No data available for Regulatory Elements for KMT2A Gene

Proteins for KMT2A Gene

  • Protein details for KMT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03164-KMT2A_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase 2A
    Protein Accession:
    Q03164
    Secondary Accessions:
    • E9PQG7
    • Q13743
    • Q13744
    • Q14845
    • Q16364
    • Q59FF2
    • Q6UBD1
    • Q9HBJ3
    • Q9UD94
    • Q9UMA3

    Protein attributes for KMT2A Gene

    Size:
    3969 amino acids
    Molecular mass:
    431764 Da
    Quaternary structure:
    • MLL cleavage product N320 heterodimerizes with MLL cleavage product C180 (via SET and FYRC domains). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, HCFC2, WDR5, DPY30 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5; the interaction is direct. Interacts with KAT8/MOF; the interaction is direct. Interacts with SBF1 and PPP1R15A. Interacts with ZNF335. Interacts with CLOCK and ARNTL/BMAL1 in a circadian manner (By similarity).
    SequenceCaution:
    • Sequence=AAA58669.1; Type=Frameshift; Positions=317, 380; Evidence={ECO:0000305}; Sequence=AAG26332.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD92745.1; Type=Frameshift; Positions=1098; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KMT2A Gene

    Alternative splice isoforms for KMT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KMT2A Gene

Proteomics data for KMT2A Gene at MOPED

Post-translational modifications for KMT2A Gene

  • Proteolytic cleavage by TASP1 generates MLL cleavage product N320 and MLL cleavage product C180, which reassemble through a non-covalent association. 2 cleavage sites exist, cleavage site 1 (CS1) and cleavage site 2 (CS2), to generate MLL cleavage products N320 and C180. CS2 is the major site.
  • Ubiquitination at Lys216, Lys220, Lys221, Lys645, Lys3707, and Lys3784
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KMT2A Gene

Domains for KMT2A Gene

Gene Families for KMT2A Gene

HGNC:
  • KMT :Chromatin-modifying enzymes / K-methyltransferases
  • PHF :Zinc fingers, PHD-type

Graphical View of Domain Structure for InterPro Entry

Q03164

UniProtKB/Swiss-Prot:

KMT2A_HUMAN :
  • Q03164
Domain:
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • The SET domain structure is atypical and is not in an optimal position to have methyltransferase activity. It requires other components of the MLL1/MLL complex, such as ASH2L or RBBP5, to order the active site and obtain optimal histone methyltransferase activity.
  • The CXXC-type zinc finger binds bind to nonmethyl-CpG dinucleotides.
  • Contains 3 A.T hook DNA-binding domains.
  • Contains 1 bromo domain.
  • Contains 1 FYR C-terminal domain.
  • Contains 1 FYR N-terminal domain.
  • Contains 1 post-SET domain.
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
Similarity:
  • Contains 1 CXXC-type zinc finger.
  • Contains 3 PHD-type zinc fingers.
genes like me logo Genes that share domains with KMT2A: view

No data available for Suggested Antigen Peptide Sequences for KMT2A Gene

Function for KMT2A Gene

Molecular function for KMT2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of Lys-4 of histone H3 (H3K4me) complex and acetylation of Lys-16 of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, while it has higher activity toward H3 acetylated on Lys-9. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of Lys-4 of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity).

Enzyme Numbers (IUBMB) for KMT2A Gene

Gene Ontology (GO) - Molecular Function for KMT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003677 DNA binding --
GO:0003680 AT DNA binding NAS 1423624
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10821850
genes like me logo Genes that share ontologies with KMT2A: view
genes like me logo Genes that share phenotypes with KMT2A: view

Animal Models for KMT2A Gene

MGI Knock Outs for KMT2A:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targeting and HOMER Transcription for KMT2A Gene

Localization for KMT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KMT2A Gene

Nucleus.
MLL cleavage product N320: Nucleus.
MLL cleavage product C180: Nucleus. Note=Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320.

Gene Ontology (GO) - Cellular Components for KMT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1423624
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0035097 histone methyltransferase complex IDA 19556245
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with KMT2A: view

No data available for Subcellular locations from COMPARTMENTS for KMT2A Gene

Pathways for KMT2A Gene

genes like me logo Genes that share pathways with KMT2A: view

Pathways by source for KMT2A Gene

1 BioSystems pathway for KMT2A Gene

Gene Ontology (GO) - Biological Process for KMT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006306 DNA methylation IEA --
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 10821850
GO:0006461 protein complex assembly IDA 15199122
genes like me logo Genes that share ontologies with KMT2A: view

Compounds for KMT2A Gene

(30) Novoseek inferred chemical compound relationships for KMT2A Gene

Compound -log(P) Hits PubMed IDs
af 10 92.1 32
ltg(4) 79.3 2
etoposide 61 34
teniposide 44 1
podophyllotoxin 43.5 2
genes like me logo Genes that share compounds with KMT2A: view

Transcripts for KMT2A Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KMT2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KMT2A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KMT2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^
SP1: - -
SP2:
SP3:
SP4:
SP5: - - - - - - -
SP6:
SP7:
SP8: -
SP9: - - -
SP10: - - - - -
SP11: -
SP12:
SP13:
SP14: -

ExUns: 19 ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KMT2A Gene

GeneLoc Exon Structure for
KMT2A
ECgene alternative splicing isoforms for
KMT2A

Expression for KMT2A Gene

mRNA expression in normal human tissues for KMT2A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KMT2A Gene

mRNA Expression by UniProt/SwissProt for KMT2A Gene

Q03164-KMT2A_HUMAN
Tissue specificity: Heart, lung, brain and T- and B-lymphocytes
genes like me logo Genes that share expressions with KMT2A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KMT2A Gene

Orthologs for KMT2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KMT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLL 35
  • 99.67 (n)
  • 99.77 (a)
MLL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KMT2A 35
  • 91.13 (n)
  • 94.75 (a)
KMT2A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KMT2A 35
  • 91.59 (n)
  • 95.36 (a)
KMT2A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kmt2a 35
  • 88.51 (n)
  • 91.2 (a)
Kmt2a 36
  • 91 (a)
OneToOne
Mll1 16
oppossum
(Monodelphis domestica)
Mammalia KMT2A 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KMT2A 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kmt2a 35
  • 88.47 (n)
  • 91.45 (a)
chicken
(Gallus gallus)
Aves KMT2A 36
  • 80 (a)
OneToOne
MLL 35
  • 77.08 (n)
  • 81.46 (a)
lizard
(Anolis carolinensis)
Reptilia KMT2A 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kmt2a 35
Str.3868 35
zebrafish
(Danio rerio)
Actinopterygii kmt2a 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trx 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SET1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for KMT2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KMT2A Gene

ENSEMBL:
Gene Tree for KMT2A (if available)
TreeFam:
Gene Tree for KMT2A (if available)

Paralogs for KMT2A Gene

Paralogs for KMT2A Gene

genes like me logo Genes that share paralogs with KMT2A: view

Variants for KMT2A Gene

Sequence variations from dbSNP and Humsavar for KMT2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471380 -- 118,453,272(-) gaggc(A/T)tcatg intron-variant
rs471406 -- 118,453,270(-) ggcat(C/T)atggg intron-variant
rs472368 -- 118,453,140(-) agcta(A/G)aggtg intron-variant
rs474155 -- 118,468,058(-) AAAAA(A/G)CAAAA intron-variant
rs474257 -- 118,468,021(-) TGCTC(C/T)ATAAA intron-variant

Relevant External Links for KMT2A Gene

HapMap Linkage Disequilibrium report
KMT2A
Human Gene Mutation Database (HGMD)
KMT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KMT2A Gene

Disorders for KMT2A Gene

(1) OMIM Diseases for KMT2A Gene (159555)

UniProtKB/Swiss-Prot

KMT2A_HUMAN
  • Wiedemann-Steiner syndrome (WDSTS) [MIM:605130]: A syndrome characterized by hairy elbows (hypertrichosis cubiti), intellectual disability, a distinctive facial appearance, and short stature. Facial characteristics include long eyelashes, thick or arched eyebrows with a lateral flare, and downslanting and vertically narrow palpebral fissures. {ECO:0000269 PubMed:22795537}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Chromosomal aberrations involving KMT2A are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins KMT2A-MLLT1, KMT2A-MLLT3 and KMT2A-ELL interact with PPP1R15A and, on the contrary to unfused KMT2A, inhibit PPP1R15A-induced apoptosis. {ECO:0000269 PubMed:10490642}.
  • Note=A chromosomal aberration involving KMT2A may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11. {ECO:0000269 PubMed:10490642}.

(63) Novoseek inferred disease relationships for KMT2A Gene

Disease -log(P) Hits PubMed IDs
acute leukemia 89.7 140
leukemogenesis 89.4 48
leukemia 88.7 208
acute monocytic leukemia 87.9 23
lymphoblastic leukemia acute 87.1 98
genes like me logo Genes that share disorders with KMT2A: view

Publications for KMT2A Gene

  1. The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicing. (PMID: 7598802) Mbangkollo D. … Diaz M.O. (DNA Cell Biol. 1995) 3 4 23
  2. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. (PMID: 1720549) Ziemin-van der Poel S. … Rowley J.D. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 23
  3. Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias. (PMID: 8703835) Nilson I. … Marschalek R. (Br. J. Haematol. 1996) 3 4 23
  4. Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. (PMID: 8950979) Taki T. … Morishita K. (Oncogene 1996) 3 4 23
  5. ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). (PMID: 9694699) Taki T. … Hayashi Y. (Blood 1998) 3 4 23

Products for KMT2A Gene

Sources for KMT2A Gene

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