Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KMT2A Gene

protein-coding   GIFtS: 46
GCID: GC11P118313

Lysine (K)-Specific Methyltransferase 2A

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
(Previous symbol: MLL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lysine (K)-Specific Methyltransferase 2A1 2     MLL/GAS72
MLL1 2 3 5     MLL1A2
HRX2 3 5     TET1-MLL2
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila)1 2     CDK6/MLL Fusion Protein2
Lysine N-Methyltransferase 2A2 3     Histone-Lysine N-Methyltransferase 2A2
Trithorax-Like Protein2 3     Mixed Lineage Leukemia 12
Zinc Finger Protein HRX2 3     MLL-AF4 Der(11) Fusion Protein2
ALL-12 3     MLL/GAS7 Fusion Protein2
CXXC72 3     MLL/GMPS Fusion Protein2
MLL12 3     ALL13
TRX12 3     EC 2.1.1.433
CXXC-Type Zinc Finger Protein 72 3     HTRX3
HTRX12 5     Myeloid/Lymphoid Or Mixed-Lineage Leukemia3
WDSTS2 5     Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 13
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila)
Homolog)1
     

External Ids:    HGNC: 71321   Entrez Gene: 42972   Ensembl: ENSG000001180587   OMIM: 1595555   UniProtKB: Q031643   

Export aliases for KMT2A gene to outside databases

Previous GC identifer: GC11P118311


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KMT2A Gene:
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during
early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of
these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which
mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed
by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble
into different multiprotein complexes that regulate the transcription of specific target genes, including many of
the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid
leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.(provided by
RefSeq, Oct 2010)

GeneCards Summary for KMT2A Gene:
KMT2A (lysine (K)-specific methyltransferase 2A) is a protein-coding gene. Diseases associated with KMT2A include acute undifferentiated leukemia, and bilineal acute leukemia. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KMT2D.

UniProtKB/Swiss-Prot: KMT2A_HUMAN, Q03164
Function: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic
subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3
(H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically
mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by
itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no
activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9',
while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9.
Promotes PPP1R15A-induced apoptosis

Gene Wiki entry for KMT2A (MLL) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for KMT2A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKMT2A promoter sequence
   Search Chromatin IP Primers for KMT2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KMT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

KMT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KMT2A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118313:  view genomic region     (about GC identifiers)

Start:
118,307,205 bp from pter      End:
118,397,539 bp from pter
Size:
90,335 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KMT2A_HUMAN, Q03164 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase 2A  
Size: 3969 amino acids; 431764 Da
Subunit: MLL cleavage product N320 heterodimerizes with MLL cleavage product C180 (via SET and FYRC domains).
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1,
HCFC2, WDR5, DPY30 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1,
TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5; the interaction is direct. Interacts with KAT8/MOF; the
interaction is direct. Interacts with SBF1 and PPP1R15A. Interacts with ZNF335
Sequence caution: Sequence=AAA58669.1; Type=Frameshift; Positions=317, 380; Sequence=AAG26332.2;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAD92745.1;
Type=Frameshift; Positions=1098;
Selected PDB 3D structures from and Proteopedia for KMT2A (see all 20):
2AGH (3D)        2J2S (3D)        2JYI (3D)        2KKF (3D)        2KU7 (3D)        2KYU (3D)    
Secondary accessions: E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3
Alternative splicing: 3 isoforms:  Q03164-1   Q03164-2   Q03164-3   

Explore the universe of human proteins at neXtProt for KMT2A: NX_Q03164

Explore proteomics data for KMT2A at MOPED

Post-translational modifications: 

  • Proteolytic cleavage by TASP1 generates MLL cleavage product N320 and MLL cleavage product C180, which reassemble
    through a non-covalent association. 2 cleavage sites exist, cleavage site 1 (CS1) and cleavage site 2 (CS2), to
    generate MLL cleavage products N320 and C180. CS2 is the major site1
  • Ubiquitination2 at Lys216, Lys220, Lys221, Lys645, Lys3707, Lys3784
  • Modification sites at PhosphoSitePlus

  • See KMT2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001184033.1  NP_005924.2  

    ENSEMBL proteins: 
     ENSP00000436786   ENSP00000432391   ENSP00000374157   ENSP00000434618   ENSP00000436564  
     ENSP00000432652   ENSP00000436700   ENSP00000376612   ENSP00000346516  

    KMT2A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KMT2A
    GenScript Custom Purified and Recombinant Proteins Services for KMT2A
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    KMT2A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KMT2A
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KMT2A
    OriGene Custom Antibody Services for KMT2A
    Novus Biologicals KMT2A Antibodies
    Search for Antibodies for KMT2A at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for KMT2A
    LSBio Antibodies in human, mouse, rat for KMT2A

    KMT2A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KMT2A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KMT2A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 12):
     IPR017956 AT_hook_DNA-bd_motif
     IPR001214 SET_dom
     IPR003889 FYrich_C
     IPR016569 MeTrfase_trithorax
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry Q03164

    ProtoNet protein and cluster: Q03164

    5 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB001965 Zn-finger-like
    IPB002857 Zn-finger
    IPB003616 SET-related region
    IPB003888 FY-rich domain


    UniProtKB/Swiss-Prot: KMT2A_HUMAN, Q03164
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Domain: The SET domain structure is atypical and is not in an optimal position to have methyltransferase activity.
    It requires other components of the MLL1/MLL complex, such as ASH2L or RBBP5, to order the active site and obtain
    optimal histone methyltransferase activity
    Domain: The CXXC-type zinc finger binds bind to nonmethyl-CpG dinucleotides
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. TRX/MLL subfamily
    Similarity: Contains 3 A.T hook DNA-binding domains
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 CXXC-type zinc finger
    Similarity: Contains 1 FYR C-terminal domain
    Similarity: Contains 1 FYR N-terminal domain
    Similarity: Contains 3 PHD-type zinc fingers
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 SET domain


    KMT2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KMT2A_HUMAN, Q03164
    Function: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic
    subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3
    (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically
    mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by
    itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no
    activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9',
    while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9.
    Promotes PPP1R15A-induced apoptosis
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003680AT DNA binding NAS1423624
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10821850
    GO:0005515protein binding IPI11313484
         
    KMT2A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KMT2A:
     Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 19 alleles(MGI details for Mll1) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    KMT2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KMT2A: Kmt2atm1.2Erns Kmt2atm1.1Brad Kmt2atm1Djab Kmt2atm1Tok

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KMT2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KMT2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KMT2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KMT2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target KMT2A:
    hsa-mir-16-5p (MIRT031581), hsa-mir-335-5p (MIRT017178), hsa-mir-128b (MIRT006587), hsa-mir-320b (MIRT036224), hsa-mir-17-5p (MIRT051043), hsa-mir-484 (MIRT042344), hsa-mir-320a (MIRT044681), hsa-let-7d-5p (MIRT032120), hsa-mir-193a-3p (MIRT044880), hsa-mir-1227-3p (MIRT036400)

    Block miRNA regulation of human, mouse, rat KMT2A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KMT2A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KMT2A
    Predesigned siRNA for gene silencing in human, mouse, rat KMT2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KMT2A

    Clone
    Products:
         
    OriGene clones in human, mouse for KMT2A (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for KMT2A
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KMT2A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KMT2A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KMT2A
    Browse ESI BIO Cell Lines and PureStem Progenitors for KMT2A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KMT2A_HUMAN, Q03164: Nucleus
    KMT2A_HUMAN, Q03164: MLL cleavage product N320: Nucleus
    KMT2A_HUMAN, Q03164: MLL cleavage product C180: Nucleus. Note=Localizes to a diffuse nuclear pattern when not
    associated with MLL cleavage product N320

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1423624
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0035097histone methyltransferase complex IDA19556245
    GO:0071339MLL1 complex IDA15960975

    KMT2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KMT2A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    3Senescence and Autophagy
    Senescence and Autophagy
    4Lysine degradation
    Lysine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KMT2A
        Senescence and Autophagy


    2 Kegg Pathways  (Kegg details for KMT2A):
        Lysine degradation
    Transcriptional misregulation in cancer


    KMT2A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KMT2A
    Interactions:

        Search GeneGlobe Interaction Network for KMT2A

    Selected Interacting proteins for KMT2A (Q031641, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684311, 3EBI-591370,EBI-79722 I2D: score=2 
    HIST1H3BP684311, 3EBI-591370,EBI-79722 I2D: score=2 
    HIST1H3CP684311, 3EBI-591370,EBI-79722 I2D: score=2 
    HIST1H3DP684311, 3EBI-591370,EBI-79722 I2D: score=2 
    HIST1H3EP684311, 3EBI-591370,EBI-79722 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006306DNA methylation IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS10821850
    GO:0006461protein complex assembly IDA15199122
    GO:0006915apoptotic process IEA--

    KMT2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KMT2A

    Selected Novoseek inferred chemical compound relationships for KMT2A gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    af 10 92.1 38 7662954 (3), 11986236 (3), 12461747 (2), 8896421 (2) (see all 22)
    ltg(4) 79.3 2 8176845 (1), 8180386 (1)
    etoposide 61 38 19587093 (6), 15528316 (5), 14630694 (4), 11170441 (3) (see all 16)
    teniposide 44 1 9752316 (1)
    podophyllotoxin 43.5 2 8319201 (1), 9789061 (1)
    bamhi 31.1 4 1465401 (1), 8319201 (1), 8320170 (1), 9331569 (1)
    dipyrone 25.3 2 17164354 (2)
    5-aza-2'deoxycytidine 19.6 3 11167824 (3)
    probenecid 15 3 12203795 (2), 14712291 (1)
    leucine 14.5 5 7662954 (2), 11756182 (1), 11986236 (1), 8950979 (1)



    KMT2A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KMT2A gene (3 alternative transcripts): 
    NM_001197104.1  NM_005933.3  NM_024891.2  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534358(uc001pta.3 uc001ptb.3) ENST00000531904(uc001psz.1 uc009zab.1)
    ENST00000389506 ENST00000532204 ENST00000529852 ENST00000527869 ENST00000533790(uc001ptd.1)
    ENST00000392873 ENST00000420751 ENST00000528278 ENST00000534085 ENST00000534678
    ENST00000525408 ENST00000527839 ENST00000354520(uc001pte.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KMT2A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KMT2A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KMT2A
    Predesigned siRNA for gene silencing in human, mouse, rat KMT2A
    Clone
    Products:
         
    OriGene clones in human, mouse for KMT2A (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for KMT2A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KMT2A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KMT2A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KMT2A
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KMT2A
      QuantiTect SYBR Green Assays in human, mouse, rat KMT2A
      QuantiFast Probe-based Assays in human, mouse, rat KMT2A

    Selected AceView cDNA sequences (see all 459):

    AI263984 AI927347 AW173345 BF969710 AA743839 AI360015 AA463620 AI417753 
    BE222755 AA419591 CD621418 AA278154 CF890791 BX094735 BE669762 AW002079 
    AU140663 BU682234 AL134544 N68008 AA749021 BG779769 AW769746 AA463268 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KMT2A (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^
    SP1:                                                                                                                                            -           -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:        -     -     -     -     -           -     -                                                                                                         

    ExUns: 19 ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26
    SP1:                                      -                                                   
    SP2:                                      -                                                   
    SP3:                                      -                                                   
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for KMT2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KMT2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KMT2A Expression
    About this image

    KMT2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KMT2A Protein Expression

    UniProtKB/Swiss-Prot: KMT2A_HUMAN, Q03164
    Tissue specificity: Heart, lung, brain and T- and B-lymphocytes

        Custom PCR Arrays for KMT2A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KMT2A
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KMT2A
    QuantiTect SYBR Green Assays in human, mouse, rat KMT2A
    QuantiFast Probe-based Assays in human, mouse, rat KMT2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KMT2A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mll15
    Kmt2a1
    myeloid/lymphoid or mixed-lineage leukemia 15
    lysine (K)-specific methyltransferase 2A1
    88.51(n)1
    91.2(a)1
      9 (24.84 cM)5
    2141621  NM_001081049.11  NP_001074518.11 
     448033555 
    chicken
    (Gallus gallus)
    Aves MLL1 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 77.08(n)
    81.46(a)
      414897  XM_004948055.1  XP_004948112.1 
    lizard
    (Anolis carolinensis)
    Reptilia KMT2A6
    lysine (K)-specific methyltransferase 2A
    69(a)
    1 ↔ 1
    GL343767.1(48798-70588)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.38682 Transcribed sequence with moderate similarity to protein more 78.34(n)    AL850257.2 
    zebrafish
    (Danio rerio)
    Actinopterygii 570891562   -- 74.63(n)    57089156 
    fruit fly
    (Drosophila melanogaster)
    Insecta trx6
    trithorax
    18(a)
    1 → many
    3R(10089080-10112623)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET16
    Histone methyltransferase, subunit of the COMPASS ...
    20(a)
    1 → many
    VIII(346043-349285) YHR119W


    ENSEMBL Gene Tree for KMT2A (if available)
    TreeFam Gene Tree for KMT2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KMT2A gene
    KMT2D2  EZH12  SETD1B2  KMT2C2  SETD1A2  EZH22  ENSG000002723332  
    14 SIMAP similar genes for KMT2A using alignment to 6 protein entries:     KMT2A_HUMAN (see all proteins):
    MLL-MAML2    MLL-TET1    MLL/AF6 fusion    MLL/GAS7    MLL/MAML2 fusion    TET1-MLL
    AF-9/MLL fusion    MLL/CALM fusion    ACTN4-MLL    MLL-ACTN4    MLL    MLL/AF4 fusion
    MLL/AF10 fusion    MLL2

    KMT2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KMT2A (see all 1795)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350678471,2
    C--114246630(+) AAAAA-/AGAAAA 2 -- int10--------
    rs1415629701,2
    --118171861(+) CCATCC/TCGGGA 2 -- int10--------
    rs723276301,2
    C--118171999(+) TTTTC-/CTCT  
     CGGGCGT
    CTCTC
    2 -- int10--------
    rs93327481,2
    C,F--118172017(+) TCGGGCGTCTC  
     TCGGG
    /-
    TGATG
    2 -- int11Minor allele frequency- -:0.05NS 150
    rs93327491,2
    C,F,H--118172070(+) TCCCTT/GCCAGC 2 -- int111Minor allele frequency- G:0.18NS EA NA EU 1717
    rs1881314321,2
    --118172087(+) CTTTCA/GAAAAC 2 -- int10--------
    rs1451931131,2
    C--118172304(+) CTCTT-/CCCCCC 2 -- int10--------
    rs93327501,2
    C,F--118172310(+) CCCCCA/C/GCCGCC 2 -- int1 trp31NS 162
    rs93327511,2
    C,F--118172311(+) CCCCCC/TCGCCC 2 -- int1 trp31Minor allele frequency- T:0.01NS 162
    rs1119031031,2
    C,F--118172412(+) AGTGGC/TATCTT 2 -- int12Minor allele frequency- T:0.02NA 122

    HapMap Linkage Disequilibrium report for KMT2A (118307205 - 118397539 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KMT2A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KMT2A
    DNA2.0 Custom Variant and Variant Library Synthesis for KMT2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 159555   
    OMIM disorders: 605130  
    UniProtKB/Swiss-Prot: KMT2A_HUMAN, Q03164
  • Wiedemann-Steiner syndrome (WDSTS) [MIM:605130]: A syndrome characterized by hairy elbows (hypertrichosis
    cubiti), intellectual disability, a distinctive facial appearance, and short stature. Facial characteristics
    include long eyelashes, thick or arched eyebrows with a lateral flare, and downslanting and vertically narrow
    palpebral fissures. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Chromosomal aberrations involving KMT2A are a cause of acute leukemias. Translocation
    t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation
    t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23)
    with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with
    MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1;
    translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation
    t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3)
    with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1.
    Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation
    t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins KMT2A-MLLT1, KMT2A-MLLT3
    and KMT2A-ELL interact with PPP1R15A and, on the contrary to unfused KMT2A, inhibit PPP1R15A-induced apoptosis
  • Note=A chromosomal aberration involving KMT2A may be a cause of chronic neutrophilic leukemia.
    Translocation t(4;11)(q21;q23) with SEPT11

  • Selected diseases for KMT2A (see all 70):    About MalaCards
    acute undifferentiated leukemia    bilineal acute leukemia    acute myeloid leukemia with 11q23 abnormalities    acute biphenotypic leukemia
    wiedemann-steiner syndrome    virus associated hemophagocytic syndrome    precursor b-cell acute lymphoblastic leukemia    chronic neutrophilic leukemia
    leukemia    congenital mesoblastic nephroma    lymphoid leukemia    intravascular large b-cell lymphoma
    pre-b-cell acute lymphoblastic leukemia    acute lymphoblastic leukemia, childhood    shwachman-diamond syndrome    acute monocytic leukemia
    cytogenetically normal acute myeloid leukemia    mesoblastic nephroma    myeloid leukemia    primary mediastinal large b-cell lymphoma


    KMT2A for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for KMT2A gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute leukemia 89.7 192 8443374 (4), 11069023 (3), 8824725 (3), 9447829 (3) (see all 99)
    leukemogenesis 89.4 54 12941810 (2), 16990610 (2), 16213369 (2), 9594441 (1) (see all 45)
    leukemia 88.7 522 12759932 (6), 8389614 (6), 10463613 (5), 9546437 (5) (see all 99)
    acute monocytic leukemia 87.9 26 15897884 (2), 20303016 (2), 11289145 (2), 9594441 (1) (see all 20)
    lymphoblastic leukemia acute 87.1 108 7579356 (2), 10588740 (2), 19229974 (2), 17690691 (2) (see all 82)
    aml adult 75.7 17 8616778 (3), 10846829 (2), 8656671 (1), 9436917 (1) (see all 9)
    chromosomal aberrations 75 49 9436917 (4), 11840285 (2), 11809673 (2), 19587093 (2) (see all 34)
    lymphoblastic leukemia acute childhood 72.9 13 9264370 (2), 11397475 (1), 17875318 (1), 16404744 (1) (see all 12)
    leukemia myelomonocytic acute 72.8 7 7948964 (1), 8988051 (1), 9846019 (1), 10086743 (1) (see all 7)
    aml childhood 70.8 9 11733351 (2), 17408461 (1), 15010072 (1), 15217837 (1) (see all 6)


    Export disorders for KMT2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KMT2A gene, integrated from 10 sources (see all 823):
    (articles sorted by number of sources associating them with KMT2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23). (PubMed id 11433529)1, 2, 9 Daheron L.... Roche J. (Genes Chromosomes Cancer 2001)
    2. The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicing. (PubMed id 7598802)1, 2, 9 Mbangkollo D.... Diaz M.O. (DNA Cell Biol. 1995)
    3. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. (PubMed id 12482972)1, 2, 9 Hsieh J.J.-D....Korsmeyer S.J. (Mol. Cell. Biol. 2003)
    4. A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. (PubMed id 12618766)1, 2, 9 Chinwalla V....Rowley J.D. (Oncogene 2003)
    5. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). (PubMed id 10588740)1, 2, 9 Taki T.... Hayashi Y. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). (PubMed id 9694699)1, 2, 9 Taki T.... Hayashi Y. (Blood 1998)
    7. Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias. (PubMed id 8703835)1, 2, 9 Nilson I....Marschalek R. (Br. J. Haematol. 1996)
    8. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. (PubMed id 1720549)1, 3, 9 Ziemin-van der Poel S....Rowley J.D. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    9. Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia. (PubMed id 14978793)1, 2, 9 von Bergh A.R.M.... Schuuring E. (Genes Chromosomes Cancer 2004)
    10. FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23). (PubMed id 14999297)1, 2, 9 Kojima K.... Fujita S. (Leukemia 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4297 HGNC: 7132 AceView: MLL Ensembl:ENSG00000118058 euGenes: HUgn4297
    ECgene: KMT2A Kegg: 4297 H-InvDB: KMT2A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KMT2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KMT2A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mll/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KMT2A gene:
    Search GeneIP for patents involving KMT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KMT2A
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KMT2A   OriGene RNAi products in human, mouse, rat for KMT2A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KMT2A  
     OriGene qSTAR qPCR primer pairs in human, mouse for KMT2A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KMT2A   OriGene Custom Protein Services for KMT2A  

     
     
     Block miRNA regulation of human, mouse, rat KMT2A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KMT2A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KMT2A Predesigned siRNA for gene silencing in human, mouse, rat KMT2A
     QuantiFast Probe-based Assays in human, mouse, rat KMT2A QuantiTect SYBR Green Assays in human, mouse, rat KMT2A
     Custom PCR Arrays for KMT2A Search Chromatin IP Primers for KMT2A
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KMT2A Search GeneGlobe Interaction Network for KMT2A
     Search Regulatory tfbs for KMT2A
     GenScript Custom Purified and Recombinant Proteins Services for KMT2A GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for KMT2A
     GenScript Custom Assay Services for KMT2A GenScript Custom overexpressing Cell Line Services for KMT2A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KMT2A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KMT2A antibodies
     Search for Antibodies for KMT2A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KMT2A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for KMT2A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMT2A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KMT2A
     SwitchGear Promoter luciferase reporter plasmids for KMT2A
     ThermoFisher Antibodies for KMT2A
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KMT2A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KMT2A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KMT2A
     LSBio Antibodies in human, mouse, rat for KMT2A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KMT2A gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4