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KMO Gene

protein-coding   GIFtS: 63
GCID: GC01P241695

Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase)

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase)1 2
Kynurenine 3-Hydroxylase2 3
EC 1.14.13.93 8
dJ317G22.12
Kynurenine 3-Monooxygenase2

External Ids:    HGNC: 63811   Entrez Gene: 85642   Ensembl: ENSG000001170097   OMIM: 6035385   UniProtKB: O152293   

Export aliases for KMO gene to outside databases

Previous GC identifers: GC01P239781 GC01P237149 GC01P237992 GC01P238736 GC01P238020 GC01P212153


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KMO Gene:
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan
metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic
target for Huntington disease. (provided by RefSeq, Oct 2011)

GeneCards Summary for KMO Gene:
KMO (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)) is a protein-coding gene. Diseases associated with KMO include transient cerebral ischemia, and pneumococcal meningitis. GO annotations related to this gene include kynurenine 3-monooxygenase activity and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required
for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of
NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic
acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the
gastrointestinal tract

Gene Wiki entry for KMO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KMO gene promoter:
         FOXI1   HFH-3   p53   FOXO4   NRSF form 1   FOXD3   NF-kappaB1   NRSF form 2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKMO promoter sequence
   Search Chromatin IP Primers for KMO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KMO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42-q44   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q42-q44

KMO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KMO gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P241695:  view genomic region     (about GC identifiers)

Start:
241,695,434 bp from pter      End:
241,758,944 bp from pter
Size:
63,511 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KMO_HUMAN, O15229 (See protein sequence)
Recommended Name: Kynurenine 3-monooxygenase  
Size: 486 amino acids; 55810 Da
Cofactor: FAD
Miscellaneous: Increased in neuroinflammatory conditions. Inhibitors are investigated as potential neuroprotective
drugs since they lead to an increased level of kynurenic acid, a neuroprotective NMDA receptor agonist
Secondary accessions: A2A2U8 A2A2U9 A2A2V0 Q5SY07 Q5SY08 Q5SY09
Alternative splicing: 3 isoforms:  O15229-1   O15229-2   O15229-3   (Gene model based on mouse cDNA data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KMO: NX_O15229

Explore proteomics data for KMO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KMO (O15229) (see all 7)
     MMIALPN  GQGMNAG  SFTCTLF  GRSINLAL 


    See KMO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003670.2  
    ENSEMBL proteins: 
     ENSP00000355516   ENSP00000355517   ENSP00000355515   ENSP00000355513  
    Reactome Protein details: O15229

    KMO Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for KMO (Kynurenine 3-Monooxygenase/KMO)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for KMO
    OriGene Protein Over-expression Lysate for KMO
    OriGene MassSpec for KMO
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    Novus Biologicals KMO Protein
    Novus Biologicals KMO Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KMO

    KMO Antibody Products:

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    Abcam antibodies for KMO
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    LSBio Antibodies in human, mouse, rat for KMO

    KMO Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for KMO
    Cloud-Clone Corp. CLIAs for KMO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002938 mOase_FAD-bd
     IPR027545 Kynurenine_monooxygenase
     IPR003042 Rng_hydrolase-like

    Graphical View of Domain Structure for InterPro Entry O15229

    ProtoNet protein and cluster: O15229

    UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
    Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily


    KMO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KMO_HUMAN, O15229
    Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required
    for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of
    NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic
    acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the
    gastrointestinal tract
    Catalytic activity: L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=24.1 uM for L-kynurenine; Vmax=8.5 umol/min/mg enzyme; pH
    dependence: Optimum pH is 7.5;

         Genatlas biochemistry entry for KMO:
    kynurenine 3-monooxygenase,55.8kDa,NADPH flavin monooxygenase,expressed in liver,placenta,kidney

         Enzyme Number (IUBMB): EC 1.14.13.91 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004502kynurenine 3-monooxygenase activity IDA10672018
    GO:0016174NAD(P)H oxidase activity IDA10672018
    GO:0050660flavin adenine dinucleotide binding IDA10672018
         
    KMO for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KMO:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Kmo (no phenotypes)

    KMO for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KMO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KMO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KMO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KMO

    miRNA
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    Block miRNA regulation of human, mouse, rat KMO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KMO (see all 17):
    hsa-miR-141* hsa-miR-641 hsa-miR-4325 hsa-miR-1299 hsa-miR-548c-3p hsa-miR-616 hsa-miR-4303 hsa-miR-3606
    SwitchGear 3'UTR luciferase reporter plasmidKMO 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KMO
    Predesigned siRNA for gene silencing in human, mouse, rat KMO

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: KMO (NM_003679)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KMO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KMO_HUMAN, O15229: Mitochondrion outer membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane ISS10672018
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005829cytosol TAS--
    GO:0016021integral component of membrane IEA--

    KMO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KMO About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan catabolism0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tryptophan degradation via kynurenine0.00
    4tryptophan utilization II
    tryptophan utilization II0.71
    NAD de novo biosynthesis0.00
    tryptophan utilization I0.71
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde0.00
    tryptophan degradation0.00
    5Nicotinate and nicotinamide metabolism
    NAD metabolism0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KMO
        NAD metabolism

    Selected BioSystems Pathways for KMO (see all 7)
        NAD de novo biosynthesis
    Selenium Pathway
    tryptophan degradation via kynurenine
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    tryptophan degradation

    1 Reactome Pathway for KMO
        Tryptophan catabolism


    2 Kegg Pathways  (Kegg details for KMO):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3


    KMO for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KMO: 

              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KMO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KMO (O152293 ENSP000003555174) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COQ3Q9NZJ63, ENSP000002547594I2D: score=1 STRING: ENSP00000254759
    ARFGAP1Q8N6T33I2D: score=5 
    ACAA1P091103I2D: score=1 
    ACAT1P247523I2D: score=1 
    ADSLP305663I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006569tryptophan catabolic process TAS--
    GO:0009435NAD biosynthetic process IEA--
    GO:0009651response to salt stress IDA10672018
    GO:0019441tryptophan catabolic process to kynurenine IEA--
    GO:0019674NAD metabolic process ----

    KMO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for KMO
      Browse compounds at ApexBio 

    Compounds for KMO available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Metyrapone11-beta hydroxylase inhibitor[54-36-4]
    DMOGProlylhydroxylase inhibitor[89464-63-1]
    Ro 61-8048Potent kynurenine 3-hydroxylase inhibitor[199666-03-0]

    9 HMDB Compounds for KMO    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydroxykynurenine3-(3-hydroxyanthraniloyl)-Alanine (see all 7)484-78-6--
    L-Kynurenine(S)-alpha,2-diamino-3-hydroxy-gamma-oxo-Benzenebutanoate (see all 15)343-65-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    Quinolinic acidpyridine-2,3-carboxylate (see all 10)89-00-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for KMO gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (m-nitrobenzoyl)alanine 96 3 12354294 (1), 18954092 (1)
    kynurenine 95.5 90 8239646 (8), 18954092 (4), 9291104 (3), 15206781 (3) (see all 32)
    3-hydroxykynurenine 92 17 12354294 (3), 2321759 (1), 18954092 (1), 8239646 (1) (see all 8)
    kynurenic acid 88.6 15 15829251 (3), 12354294 (3), 11982504 (1), 15206781 (1) (see all 7)
    3-hydroxyanthranilic acid 88.4 8 9291104 (3), 16956766 (1), 11795205 (1), 10966936 (1)
    quinolinic acid 83.2 7 9291104 (3), 12354294 (1), 11795205 (1), 10966936 (1)
    flavin 68.7 10 18954092 (3), 12230548 (1), 9237672 (1)
    quinine 68.5 8 12354294 (3), 8293279 (2), 8245962 (1), 15206781 (1) (see all 5)
    indoleamine 68.4 2 11795205 (1), 12165503 (1)
    l-tryptophan 68.3 3 9291104 (2), 8417138 (1)



    KMO for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KMO gene: 
    NM_003679.4  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366558(uc001hyy.3) ENST00000366559(uc009xgo.2 uc009xgp.3)
    ENST00000484628 ENST00000480967 ENST00000484229 ENST00000477907 ENST00000366557
    ENST00000481087 ENST00000431245 ENST00000366555

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KMO (see all 17):
    hsa-miR-141* hsa-miR-641 hsa-miR-4325 hsa-miR-1299 hsa-miR-548c-3p hsa-miR-616 hsa-miR-4303 hsa-miR-3606
    SwitchGear 3'UTR luciferase reporter plasmidKMO 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: KMO (NM_003679)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KMO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO
    Primer
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    OriGene qPCR primer pairs and template standards for KMO
    OriGene qSTAR qPCR primer pairs in human, mouse for KMO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KMO
      QuantiTect SYBR Green Assays in human, mouse, rat KMO
      QuantiFast Probe-based Assays in human, mouse, rat KMO

    Selected AceView cDNA sequences (see all 93):

    BX334999 BM684741 H47346 AU135363 BX643377 BX399335 CF528266 CR593684 
    CR601734 CR613404 CA398018 AA862887 AI261812 AI262990 BC005297 AA971307 
    CA398019 N57051 AI949852 CD640024 AI341967 AI074145 H96044 CD641673 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KMO (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                -     -                 -                       -                                                     -               
    SP2:                                -     -                 -                       -                                                                     
    SP3:                                -                       -                       -                                                                     
    SP4:                                                        -                                                                                             
    SP5:                                -     -     -     -     -                       -                                                                     


    ECgene alternative splicing isoforms for KMO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KMO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAATGT
    KMO Expression
    About this image


    KMO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Mature B-Cells Peripheral Blood
    KMO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KMO Protein Expression

    UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
    Tissue specificity: Highest levels in placenta and liver. Detectable in kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including KMO: 
              Amino Acid Metabolism I in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat KMO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KMO gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kmo1 , 5 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) less1, 5 81.54(n)1
    80.21(a)1
      1 (81.60 cM)5
    982561  NM_133809.11  NP_598570.11 
     1756203815 
    chicken
    (Gallus gallus)
    Aves KMO1 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) less 69.16(n)
    70.51(a)
      424041  XM_004942567.1  XP_004942624.1 
    lizard
    (Anolis carolinensis)
    Reptilia KMO6
    kynurenine 3-monooxygenase (kynurenine 3-hydroxyla...
    67(a)
    1 ↔ 1
    GL343645.1(186578-217872)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144292 Xenopus laevis transcribed sequence with weak similarity to protein refNP_003670.1 (H.sapiens) kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) [Homo sapiens] less 76.32(n)    BJ054972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kmo1 kynurenine 3-monooxygenase 66.52(n)
    65.68(a)
      368242  NM_001040306.2  NP_001035396.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta cn1 , 3 ommochrome biosynthesis kynurenine
    3-monooxygenase less3
    cinnabar1
    45(a)3
    49.65(n)1
    44.55(a)1
      2 43E163
    357241  NM_078927.21  NP_523651.31 
    worm
    (Caenorhabditis elegans)
    Secernentea R07B7.51 , 3 Monooxygenase3
    R07B7.51
    45(a)
    (best of 2)3
    53.04(n)1
    47.9(a)1
      V(12071388-12073115)3
    1796571  NM_073624.31  NP_506025.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BNA4(YBL098W)4
    BNA41
    Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease less4
    BNA41
    50.28(n)1
    40.1(a)1
      2(39145-40527)4
    8521791, 4  NP_009454.11, 4 


    ENSEMBL Gene Tree for KMO (if available)
    TreeFam Gene Tree for KMO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for KMO (see all 1403)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156503611,2
    C,F--241693499(+) AACTTC/TCGTTT 1 -- us2k10--------
    rs1146001041,2
    F--241693529(+) ATGCAT/CAAACA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs727660101,2
    --241693543(+) CTGGGC/TGCAGT 1 -- us2k10--------
    rs1822762731,2
    --241693566(+) TAATTC/TCAGCA 1 -- us2k10--------
    rs1869141911,2
    --241693590(+) AGGCGG/TGTGGA 1 -- us2k10--------
    rs1997051191,2
    --241693658(+) GAAAA-/AATAATAC 1 -- cds10--------
    rs1901475401,2
    --241693673(+) ATTAGC/GTAGGC 1 -- us2k10--------
    rs1415119611,2
    --241693766(+) TGAGCC/GGAGAT 1 -- us2k10--------
    rs1828453311,2
    --241693771(+) CGAGAC/TTGCAC 1 -- us2k10--------
    rs1883176141,2
    --241693884(+) TACTCA/CTACAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KMO (241695434 - 241758944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for KMO:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726207CNV Deletion23290073
    esv2726218CNV Deletion23290073
    esv2670654CNV Deletion23128226
    nsv525983CNV Loss19592680
    nsv873368CNV Gain21882294
    esv8534CNV Gain19470904
    nsv873371CNV Gain21882294
    nsv873372CNV Gain21882294

    Human Gene Mutation Database (HGMD): KMO
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KMO
    DNA2.0 Custom Variant and Variant Library Synthesis for KMO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603538    OMIM disorders: --

    15 diseases for KMO:    
    About MalaCards
    transient cerebral ischemia    pneumococcal meningitis    paroxysmal dyskinesia    huntington's disease
    ischemia    meningitis    neurologic diseases    cerebritis
    brain injury    schizophrenia    multiple sclerosis    obesity
    pancreatitis    malaria    neuronitis


    KMO for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    3 Novoseek inferred disease relationships for KMO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    transient cerebral ischemia 58.3 1 8417138 (1)
    cerebral ischemia 41.9 3 8239646 (2), 8245962 (1)
    ischemia 22.6 3 18954092 (1), 8239646 (1)

    Genetic Association Database (GAD): KMO
    Human Genome Epidemiology (HuGE) Navigator: KMO (3 documents)

    Export disorders for KMO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KMO gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with KMO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of human kynurenine 3- monooxygenase. (PubMed id 9237672)1, 2, 3, 9 Alberati-Giani D....Malherbe P. (FEBS Lett. 1997)
    2. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. (PubMed id 16716206)1, 4, 9 Aoyama N....Ozaki N. (Genes Brain Behav. 2006)
    3. Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. (PubMed id 10672018)1, 2, 9 Breton J.... Isacchi A. (Eur. J. Biochem. 2000)
    4. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PubMed id 19626040)1, 4 McCauley J.L....Haines J.L. (Genes Immun. 2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Endogenous kynurenines as targets for drug discovery and development. (PubMed id 12402501)1, 2 Stone T.W. and Darlington L.G. (Nat. Rev. Drug Discov. 2002)
    7. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. (PubMed id 11401433)1, 9 Halford S.... Hunt D.M. (Genomics 2001)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls. (PubMed id 21693093)1 Holtze M....Erhardt S. (amp 2012)
    10. Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: an association study. (PubMed id 21030213)1 Holtze M....Schalling M. (Schizophr. Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8564 HGNC: 6381 AceView: KMO Ensembl:ENSG00000117009 euGenes: HUgn8564
    ECgene: KMO Kegg: 8564 H-InvDB: KMO

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KMO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KMO gene:
    Search GeneIP for patents involving KMO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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