Aliases for KMO Gene
External Ids for KMO Gene
Previous GeneCards Identifiers for KMO Gene
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
GeneCards Summary for KMO Gene
KMO (Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase)) is a Protein Coding gene. Diseases associated with KMO include transient cerebral ischemia and pneumococcal meningitis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include flavin adenine dinucleotide binding and kynurenine 3-monooxygenase activity.
UniProtKB/Swiss-Prot for KMO Gene
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract