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KMO Gene(Protein Coding)

Kynurenine 3-Monooxygenase

GCID:
GC01P241532
GIFtS:
54
Genes Participants
UDN Logo

Aliases for KMO Gene

Aliases for KMO Gene

  • Kynurenine 3-Monooxygenase 2 3 5
  • Kynurenine 3-Hydroxylase 2 3 4
  • EC 1.14.13.9 4 56
  • Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase) 2
  • DJ317G22.1 3

External Ids for KMO Gene

Previous GeneCards Identifiers for KMO Gene

  • GC01P239781
  • GC01P237149
  • GC01P237992
  • GC01P238736
  • GC01P238020
  • GC01P241695
  • GC01P212153

Summaries for KMO Gene

Entrez Gene Summary for KMO Gene

  • This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]

GeneCards Summary for KMO Gene

KMO (Kynurenine 3-Monooxygenase) is a Protein Coding gene. Diseases associated with KMO include Transient Cerebral Ischemia and Benign Paroxysmal Positional Nystagmus. Among its related pathways are superpathway of tryptophan utilization and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include flavin adenine dinucleotide binding and kynurenine 3-monooxygenase activity.

UniProtKB/Swiss-Prot for KMO Gene

  • Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Tocris Summary for KMO Gene

  • Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-beta hydroxylase (E.C. 1.14.15.4), and LTB4 omega-hydroxylase (E.C. 1.14.13.30).

Gene Wiki entry for KMO Gene

Additional gene information for KMO Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KMO Gene

Genomics for KMO Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for KMO Gene

Promoters and enhancers for KMO Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I241530 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 588.9 +2.1 2120 6.3 PKNOX1 ATF1 FOXA2 ARNT SIN3A IRF4 YY1 E2F8 ARID2 ATF7 KMO CHML LOC105373233
GH01I241529 Enhancer 0.2 FANTOM5 552.2 -2.0 -1953 0 KMO FH
GH01I241550 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 46.1 +20.0 20027 2.2 ATF1 ARNT IRF4 ATF7 RUNX3 NCOA1 REST MEF2D ATF4 GMEB1 KMO LOC105373233
GH01I241603 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 27.6 +76.6 76607 10.5 ATF1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A YBX1 YY1 TCF12 ARID2 KMO CHML WDR64 PLD5 OPN3 GC01M241589 LOC105373233
GH01I241542 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 28.8 +10.6 10639 0.9 SMARCE1 DPF2 ELF1 FOXA1 ZNF217 CTBP1 GATA3 JUND CREB1 KMO LOC105373230 LOC105373233
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KMO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KMO gene promoter:

Genomic Locations for KMO Gene

Genomic Locations for KMO Gene
chr1:241,531,889-241,595,647
(GRCh38/hg38)
Size:
63,759 bases
Orientation:
Plus strand
chr1:241,695,434-241,758,944
(GRCh37/hg19)

Genomic View for KMO Gene

Genes around KMO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KMO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KMO Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KMO Gene

Proteins for KMO Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KMO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15229-KMO_HUMAN
    Recommended name:
    Kynurenine 3-monooxygenase
    Protein Accession:
    O15229
    Secondary Accessions:
    • A2A2U8
    • A2A2U9
    • A2A2V0
    • Q5SY07
    • Q5SY08
    • Q5SY09

    Protein attributes for KMO Gene

    Size:
    486 amino acids
    Molecular mass:
    55810 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Increased in neuroinflammatory conditions. Inhibitors are investigated as potential neuroprotective drugs since they lead to an increased level of kynurenic acid, a neuroprotective NMDA receptor agonist.

    Alternative splice isoforms for KMO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KMO Gene

Protein Expression for KMO Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for KMO Gene

O15229:
  • EMRAHVNS
  • GQGMNAG
  • SFTCTLF
  • MMIALPN
  • PMRARMIH
  • GFEDCLVF
  • GRSINLAL

Post-translational modifications for KMO Gene

No Post-translational modifications

Other Protein References for KMO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KMO Gene

Gene Families for KMO Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for KMO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KMO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15229

UniProtKB/Swiss-Prot:

KMO_HUMAN :
  • Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Family:
  • Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
genes like me logo Genes that share domains with KMO: view

Function for KMO Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for KMO Gene

GENATLAS Biochemistry:
kynurenine 3-monooxygenase,55.8kDa,NADPH flavin monooxygenase,expressed in liver,placenta,kidney
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=24.1 uM for L-kynurenine {ECO:0000269 PubMed:10672018, ECO:0000269 PubMed:9237672}; Vmax=8.5 umol/min/mg enzyme {ECO:0000269 PubMed:10672018, ECO:0000269 PubMed:9237672}; pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:10672018, ECO:0000269 PubMed:9237672};
UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Enzyme Numbers (IUBMB) for KMO Gene

Phenotypes From GWAS Catalog for KMO Gene

Gene Ontology (GO) - Molecular Function for KMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004502 kynurenine 3-monooxygenase activity TAS --
GO:0016174 NAD(P)H oxidase activity IDA 10672018
GO:0016491 oxidoreductase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IDA 10672018
GO:0071949 FAD binding IEA --
genes like me logo Genes that share ontologies with KMO: view
genes like me logo Genes that share phenotypes with KMO: view

Animal Models for KMO Gene

MGI Knock Outs for KMO:
  • Kmo tm1.2Pjmi
  • Kmo tm1a(KOMP)Wtsi

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KMO Gene

Localization for KMO Gene

Subcellular locations from UniProtKB/Swiss-Prot for KMO Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KMO gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 4
plasma membrane 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane ISS 10672018
GO:0005743 mitochondrial inner membrane IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KMO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KMO Gene

Pathways & Interactions for KMO Gene

genes like me logo Genes that share pathways with KMO: view

UniProtKB/Swiss-Prot O15229-KMO_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.

Gene Ontology (GO) - Biological Process for KMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006569 tryptophan catabolic process TAS --
GO:0009435 NAD biosynthetic process IEA --
GO:0009651 response to salt stress IDA 10672018
GO:0019363 pyridine nucleotide biosynthetic process IEA --
GO:0019441 tryptophan catabolic process to kynurenine IEA --
genes like me logo Genes that share ontologies with KMO: view

No data available for SIGNOR curated interactions for KMO Gene

Drugs & Compounds for KMO Gene

Products:

  1. Drug

(15) Drugs for KMO Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metyrapone Approved, Investigational Pharma 11-beta hydroxylase inhibitor 13
Oxygen Approved, Vet_approved Pharma 0
FAD Approved Pharma 0
Water Approved Pharma 0
Quinolinic acid Experimental Pharma 0

(14) Additional Compounds for KMO Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Hydroxykynurenine
  • 3-(3-Hydroxyanthraniloyl)-Alanine
  • 3-Hydroxy-DL-kynurenine
  • 3-Hydroxy-Kynurenine
  • 3-Hydroxykynurenine
  • DL-3-Hydroxykynurenine
 484-78-6
L-3-Hydroxykynurenine
  • 3-(2-Amino-3-hydroxybenzoyl)-L-alanine
  • 3-(3-Hydroxyanthraniloyl)-L-alanine
  • 3-Hydroxy-L-kynurenine
  • L-3-HK
 606-14-4
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
 53-59-8

(4) Tocris Compounds for KMO Gene

Compound Action Cas Number
17-ODYA LTB omega-hydroxylase inhibitor 34450-18-5
DMOG Prolyl hydroxylase inhibitor 89464-63-1
Metyrapone 11-beta hydroxylase inhibitor 54-36-4
p-Chlorophenylalanine Tryptophan hydroxylase inhibitor 7424-00-2

(4) ApexBio Compounds for KMO Gene

Compound Action Cas Number
17-ODYA LTB4 ω-hydroxylase inhibitor 34450-18-5
GSK180 inhibitor of kynurenine-3-monooxygenase (KMO)
Metyrapone 54-36-4
Ro 61-8048 199666-03-0
genes like me logo Genes that share compounds with KMO: view

Drug Products

Transcripts for KMO Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KMO Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(93) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KMO Gene

Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KMO Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6: -
SP7: - -

Relevant External Links for KMO Gene

GeneLoc Exon Structure for
KMO
ECgene alternative splicing isoforms for
KMO

Expression for KMO Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KMO Gene

mRNA expression in normal human tissues for KMO Gene
mRNA expression by GTEx for KMO GenemRNA expression by BioGPS for KMO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KMO Gene

This gene is overexpressed in Liver (x24.2) and Kidney - Cortex (x6.0).

Protein differential expression in normal tissues from HIPED for KMO Gene

This gene is overexpressed in Gallbladder (42.4), Liver (7.3), and Kidney (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KMO Gene



Protein tissue co-expression partners for KMO Gene

NURSA nuclear receptor signaling pathways regulating expression of KMO Gene:

KMO

SOURCE GeneReport for Unigene cluster for KMO Gene:

Hs.744065

mRNA Expression by UniProt/SwissProt for KMO Gene:

O15229-KMO_HUMAN
Tissue specificity: Highest levels in placenta and liver. Detectable in kidney.

Evidence on tissue expression from TISSUES for KMO Gene

  • Nervous system(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with KMO: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KMO Gene

Orthologs for KMO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KMO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KMO 33 34
  • 99.18 (n)
dog
(Canis familiaris)
 Mammalia KMO 33 34
  • 88.2 (n)
cow
(Bos Taurus)
 Mammalia KMO 33 34
  • 87.63 (n)
rat
(Rattus norvegicus)
 Mammalia Kmo 33
  • 82.68 (n)
mouse
(Mus musculus)
 Mammalia Kmo 33 16 34
  • 81.54 (n)
oppossum
(Monodelphis domestica)
 Mammalia KMO 34
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KMO 34
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KMO 33 34
  • 69.16 (n)
lizard
(Anolis carolinensis)
 Reptilia KMO 34
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia kmo 33
  • 68.41 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.14429 33
zebrafish
(Danio rerio)
 Actinopterygii kmo 33 34
  • 66.52 (n)
KMO (2 of 2) 34
  • 65 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta KMO_ANOGA 33
  • 53.89 (n)
fruit fly
(Drosophila melanogaster)
 Insecta cn 35 33 34
  • 49.65 (n)
worm
(Caenorhabditis elegans)
 Secernentea R07B7.5 35 33
  • 53.04 (n)
kmo-1 34
  • 44 (a)
 OneToMany
R07B7.4 35 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes BNA4 33 34 36
  • 50.28 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGL276W 33
  • 47.22 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1968 34
  • 53 (a)
 OneToOne
bread mold
(Neurospora crassa)
 Ascomycetes NCU06924 33
  • 46.84 (n)
Species where no ortholog for KMO was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KMO Gene

ENSEMBL:
Gene Tree for KMO (if available)
TreeFam:
Gene Tree for KMO (if available)

Paralogs for KMO Gene

No data available for Paralogs for KMO Gene

Variants for KMO Gene

Sequence variations from dbSNP and Humsavar for KMO Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000065693 -- 241,553,168(+) C/T intron_variant
rs1000087078 -- 241,563,328(+) A/G intron_variant
rs1000107689 -- 241,536,580(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000145887 -- 241,547,770(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000237313 -- 241,540,128(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KMO Gene

Variant ID Type Subtype PubMed ID
dgv159e212 CNV loss 25503493
esv2670654 CNV deletion 23128226
esv2726207 CNV deletion 23290073
esv2726218 CNV deletion 23290073
esv3549543 CNV deletion 23714750
esv3578512 CNV loss 25503493
esv3589344 CNV loss 21293372
esv8534 CNV gain 19470904
nsv1002214 CNV gain 25217958
nsv525983 CNV loss 19592680
nsv549460 CNV gain 21841781

Variation tolerance for KMO Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KMO Gene

Human Gene Mutation Database (HGMD)
KMO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KMO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KMO Gene

Disorders for KMO Gene

MalaCards: The human disease database

(2) MalaCards diseases for KMO Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search KMO in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KMO

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KMO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KMO Gene

Publications for KMO Gene

  1. Cloning and functional expression of human kynurenine 3-monooxygenase. (PMID: 9237672) Alberati-Giani D … Malherbe P (FEBS letters 1997) 2 3 4 22 58
  2. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. (PMID: 16716206) Aoyama N … Ozaki N (Genes, brain, and behavior 2006) 3 22 44 58
  3. Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. (PMID: 10672018) Breton J … Isacchi A (European journal of biochemistry 2000) 3 4 22 58
  4. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley JL … Haines JL (Genes and immunity 2009) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for KMO Gene

Sources for KMO Gene

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