KMO Gene
protein-coding GIFtS: 65
GCID: GC01P241695
|
|
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
| |
Aliases
for KMO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase)1 2 | | Kynurenine 3-Hydroxylase2 3 | | EC 1.14.13.93 8 | | DJ317G22.11 | | Kynurenine 3-Monooxygenase2 |
Export aliases for KMO gene to outside databasesPrevious GC identifers: GC01P239781 GC01P237149 GC01P237992 GC01P238736 GC01P238020 GC01P212153 |
Summaries
for KMO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KMO:
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite,L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target forHuntington disease. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: KMO_HUMAN, O15229Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required forsynthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDAreceptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid mayalso affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinaltract
Gene Wiki entry for KMO
|
Genomic Views
for KMO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KMO gene promoter:
FOXI1 HFH-3 p53 FOXO4 NRSF form 1 FOXD3 NF-kappaB1 NRSF form 2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KMO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KMO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42-q44 Ensembl cytogenetic band: 1q43 HGNC cytogenetic band: 1q42-q44KMO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P241695: view genomic region
(about GC identifiers)
Start:
|
241,695,434 bp from pter |
End:
|
241,758,944 bp from pter |
Size:
|
63,511 bases |
Orientation:
|
plus strand |
|
Proteins
for KMO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KMO_HUMAN, O15229 (See
protein sequence)Recommended Name: Kynurenine 3-monooxygenase Size: 486 amino acids; 55810 Da
Cofactor: FAD
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein
Miscellaneous: Increased in neuroinflammatory conditions. Inhibitors are investigated as potential neuroprotectivedrugs since they lead to an increased level of kynurenic acid, a neuroprotective NMDA receptor agonist
Secondary accessions: A2A2U8 A2A2U9 A2A2V0 Q5SY07 Q5SY08 Q5SY09Alternative splicing: 3 isoforms: O15229-1 O15229-2 O15229-3 (Gene model based on mouse cDNA data. No experimental confirmation available)Explore the universe of human proteins at neXtProt for KMO: NX_O15229
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15229
4/7 DME Specific Peptides for KMO (O15229) (see all 7)
KMO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003670.2
ENSEMBL proteins: ENSP00000355517 ENSP00000355516 ENSP00000355515 ENSP00000355513 Reactome Protein details: O15229
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
KMO for ontologies About GeneDecksing
KMO Antibody Products:
Assay Products for KMO: |
Protein
Domains /
Families
for KMO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KMO for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15229ProtoNet protein and cluster: O15229 UniProtKB/Swiss-Prot: KMO_HUMAN, O15229Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily |
Function
for KMO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KMO_HUMAN, O15229Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required forsynthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDAreceptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid mayalso affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinaltractCatalytic activity: L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)OBiophysicochemical properties: Kinetic parameters: KM=24.1 uM for L-kynurenine; Vmax=8.5 umol/min/mg enzyme; pHdependence: Optimum pH is 7.5; Genatlas biochemistry entry for KMO:kynurenine 3-monooxygenase,55.8kDa,NADPH flavin monooxygenase,expressed in liver,placenta,kidney
Enzyme Number (IUBMB): EC 1.14.13.91 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KMO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KMO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KMO (NM_003679) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KMO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
KMO for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KMO:
|
Pathways & Interactions
for KMO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | | | 2 | Metabolism | | | 3 | NAD metabolism | | | 4 | Metabolism of amino acids and derivatives | | | 5 | Selenium Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KMO
1  GeneGo (Thomson Reuters) Pathway for KMO
4  BioSystems Pathways for KMO
3 
Reactome Pathways for KMO
2 
Kegg Pathways (Kegg details for KMO):
UniProtKB/Swiss-Prot: KMO_HUMAN, O15229Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3
KMO for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KMO
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/20 Interacting proteins for KMO (O152293 ENSP000003555174) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
KMO for ontologies About GeneDecksing
|
Drugs & Compounds
for KMO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KMO for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for KMO |
 Compounds for KMO available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Ro 61-8048 | Potent kynurenine 3-hydroxylase inhibitor | [199666-03-0] |
9 HMDB Compounds for KMO About this table
10/14 Novoseek chemical compound relationships for KMO gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| (m-nitrobenzoyl)alanine |
96 |
3 |
12354294 (1), 18954092 (1) |
| kynurenine |
95.5 |
90 |
8239646 (8), 18954092 (4), 9291104 (3), 15206781 (3) (see all 32) |
| 3-hydroxykynurenine |
92 |
17 |
12354294 (3), 2321759 (1), 18954092 (1), 8239646 (1) (see all 8) |
| kynurenic acid |
88.6 |
15 |
15829251 (3), 12354294 (3), 11982504 (1), 15206781 (1) (see all 7) |
| 3-hydroxyanthranilic acid |
88.4 |
8 |
9291104 (3), 16956766 (1), 11795205 (1), 10966936 (1) |
| quinolinic acid |
83.2 |
7 |
9291104 (3), 12354294 (1), 11795205 (1), 10966936 (1) |
| flavin |
68.7 |
10 |
18954092 (3), 12230548 (1), 9237672 (1) |
| quinine |
68.5 |
8 |
12354294 (3), 8293279 (2), 8245962 (1), 15206781 (1) (see all 5) |
| indoleamine |
68.4 |
2 |
11795205 (1), 12165503 (1) |
| l-tryptophan |
68.3 |
3 |
9291104 (2), 8417138 (1) |
Search CenterWatch for drugs/clinical trials and news about KMO
|
Transcripts
for KMO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KMO gene: NM_003679.4 Unigene Cluster for KMO: Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Hs.744065 [show with all ESTs]Unigene Representative Sequence: NM_00367910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366559(uc009xgo.2 uc009xgp.3) ENST00000366558(uc001hyy.3)
ENST00000484628 ENST00000480967 ENST00000484229 ENST00000477907 ENST00000366557
ENST00000481087 ENST00000431245 ENST00000366555
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KMO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KMO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KMO (NM_003679) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KMO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO |
Additional cDNA sequence: AF056032.1 AK291558.1 AK310937.1 BC005297.1 Y13153.1 14 DOTS entries: DT.95167751 DT.92437057 DT.100782603 DT.121407952 DT.40131123 DT.92437054 DT.100020104 DT.121407947 DT.95167750 DT.97763474 DT.40289099 DT.91788981 DT.92391534 DT.95148501 24/93 AceView cDNA sequences (see all 93): AU135363 BM684741 CR593684 CA398018 BX334999 AI261812 CR601734 CR613404 AI262990 CF528266 H47346 BX643377 BX399335 AA862887 R64497 AA971307 BI760391 AI949852 AU139079 AI434838 AA694108 CB164355 BX392589 N57051
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KMO (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KMO
|
Expression
for KMO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KMO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAAATGT
About this image
See KMO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KMO
SOURCE GeneReport for Unigene cluster: Hs.744065
UniProtKB/Swiss-Prot: KMO_HUMAN, O15229Tissue specificity: Highest levels in placenta and liver. Detectable in kidney
SABiosciences Expression via Pathway-Focused PCR Array including KMO:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KMO
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KMO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KMO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KMO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO |
Orthologs
for KMO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for KMO gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Kmo1 , 5 |
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)1, 5 |
83.11(n)1
82.46(a)1 |
|
1 (81.60 cM)5
982561 NM_133809.11 NP_598570.11
1756203815 |
chicken
(Gallus gallus) |
Aves |
KMO1 |
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
69.23(n)
70.51(a) |
|
424041 XM_421897.3 XP_421897.1 |
lizard
(Anolis carolinensis) |
Reptilia |
KMO6 |
-- |
66(a) |
1 ↔ 1 |
GL343645.1(187008-214524) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.144292 |
Xenopus laevis transcribed sequence with weak similarity more |
76.32(n) |
|
BJ054972.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
kmo1 |
kynurenine 3-monooxygenase |
66.52(n)
65.68(a) |
|
368242 NM_001040306.2 NP_001035396.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
cn1 , 3 |
ommochrome biosynthesis kynurenine
3-monooxygenase3
cinnabar1 |
45(a)3
49.65(n)1
44.55(a)1 |
|
2 43E163
357241 NM_078927.21 NP_523651.31 |
worm
(Caenorhabditis elegans) |
Secernentea |
R07B7.51 , 3 |
Monooxygenase3
Protein R07B7.51 |
45(a)
(best of 2)3
53.08(n)1
48.01(a)1 |
|
V(12071388-12073115)3
1796571 NM_073624.21 NP_506025.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
BNA4(YBL098W)4
BNA41 |
Kynurenine 3-mono oxygenase, required for the de novo more4
Bna4p1 |
50.36(n)1
40.1(a)1 |
|
2(39145-40527)4
8521791, 4 NP_009454.11, 4 |
ENSEMBL Gene Tree for KMO (if available)
TreeFam Gene Tree for KMO (if available) |
Paralogs
for KMO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KMO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KMO (241695434 - 241758944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KMO
1 Indel: 59994
Human Gene Mutation Database (HGMD): KMO
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KMO |
|
Disorders
/ Diseases
for KMO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KMO for disorders About GeneDecksing
OMIM gene information: 603538
OMIM disorders: --
12  diseases for KMO: About MalaCardshuntington's disease transient cerebral ischemia brain injury ischemia
meningitis cerebritis multiple sclerosis neurologic diseases
noma schizophrenia pancreatitis neuronitis
3 Novoseek disease relationships for KMO gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| transient cerebral ischemia |
58.3 |
1 |
8417138 (1) |
| cerebral ischemia |
41.9 |
3 |
8239646 (2), 8245962 (1) |
| ischemia |
22.6 |
3 |
18954092 (1), 8239646 (1) |
Human Genome Epidemiology (HuGE) Navigator: KMO (3 documents)
Export disorders for KMO gene to outside databases
|
Publications
for KMO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KMO gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with KMO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional expression of human kynurenine 3- monooxygenase. (PubMed id 9237672)1, 2, 3, 9 Alberati-Giani D....Malherbe P. (1997)
- Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. (PubMed id 10672018)1, 2, 9 Breton J.... Isacchi A. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Endogenous kynurenines as targets for drug discovery and development. (PubMed id 12402501)1, 2 Stone T.W. and Darlington L.G. (2002)
- Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. (PubMed id 16716206)1, 9 Aoyama N....Ozaki N. (2006)
- Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. (PubMed id 11401433)1, 9 Halford S.... Hunt D.M. (2001)
- Kynurenine 3-monooxygenase polymorphisms: relevance fo r kynurenic acid synthesis in patients with schizophrenia and healthy controls. (PubMed id 21693093)1 Holtze M....Erhardt S. (2012)
- Downregulated kynurenine 3-monooxygenase gene express ion and enzyme activity in schizophrenia and genetic association with schizophr enia endophenotypes. (PubMed id 21727251)1 Wonodi I....Schwarcz R. (2011)
- Kynurenine 3-monooxygenase (KMO) polymorphisms in sch izophrenia: An association study. (PubMed id 21030213)1 Holtze M....Schalling M. (2010)
- Follow-up examination of linkage and association to c hromosome 1q43 in multiple sclerosis. (PubMed id 19626040)1 McCauley J.L....Haines J.L. (2009)
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External Searches for KMO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing KMO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing KMO gene
(According to HUGE)
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Specialized Databases showing KMO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for KMO | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for KMO gene:
Search GeneIP for patents involving KMO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KMO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KMO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KMO | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KMO | | | OriGene Protein Over-expression Lysate for KMO | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KMO | | OriGene 3'-UTR Clone for KMO | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KMO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KMO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KMO | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KMO | | OriGene Custom Protein Services for KMO | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KMO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KMO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KMO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KMO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KMO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KMO |
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| | | | Tocris compounds for KMO |
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 | | | KMO Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO |
|  |  |  | | | | Search ThermoFisher Antibodies for KMO |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO |
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