Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KMO Gene

protein-coding   GIFtS: 66
GCID: GC01P241695

Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase)

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase)1 2
Kynurenine 3-Hydroxylase2 3
EC 1.14.13.93 8
dJ317G22.12
Kynurenine 3-Monooxygenase2

External Ids:    HGNC: 63811   Entrez Gene: 85642   Ensembl: ENSG000001170097   OMIM: 6035385   UniProtKB: O152293   

Export aliases for KMO gene to outside databases

Previous GC identifers: GC01P239781 GC01P237149 GC01P237992 GC01P238736 GC01P238020 GC01P212153


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KMO Gene:
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan
metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic
target for Huntington disease. (provided by RefSeq, Oct 2011)

GeneCards Summary for KMO Gene: 
KMO (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)) is a protein-coding gene. Diseases associated with KMO include transient cerebral ischemia, and pneumococcal meningitis, and among its related super-pathways are tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde and Metabolic pathways. GO annotations related to this gene include kynurenine 3-monooxygenase activity and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required
for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of
NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic
acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the
gastrointestinal tract

Gene Wiki entry for KMO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KMO gene promoter:
         FOXI1   HFH-3   p53   FOXO4   NRSF form 1   FOXD3   NF-kappaB1   NRSF form 2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKMO promoter sequence
   Search SABiosciences Chromatin IP Primers for KMO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KMO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42-q44   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q42-q44

KMO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KMO gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P241695:  view genomic region     (about GC identifiers)

Start:
241,695,434 bp from pter      End:
241,758,944 bp from pter
Size:
63,511 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KMO_HUMAN, O15229 (See protein sequence)
Recommended Name: Kynurenine 3-monooxygenase  
Size: 486 amino acids; 55810 Da
Cofactor: FAD
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein
Miscellaneous: Increased in neuroinflammatory conditions. Inhibitors are investigated as potential neuroprotective
drugs since they lead to an increased level of kynurenic acid, a neuroprotective NMDA receptor agonist
Secondary accessions: A2A2U8 A2A2U9 A2A2V0 Q5SY07 Q5SY08 Q5SY09
Alternative splicing: 3 isoforms:  O15229-1   O15229-2   O15229-3   (Gene model based on mouse cDNA data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KMO: NX_O15229

Explore proteomics data for KMO at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15229

  • 4/7 DME Specific Peptides for KMO (O15229) (see all 7)
     MMIALPN  GQGMNAG  SFTCTLF  GRSINLAL 

    KMO Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KMO Protein Expression
    REFSEQ proteins: NP_003670.2  
    ENSEMBL proteins: 
     ENSP00000355516   ENSP00000355517   ENSP00000355515   ENSP00000355513  
    Reactome Protein details: O15229
    Human Recombinant Protein Products for KMO: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for KMO (Kynurenine 3-Monooxygenase/KMO)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KMO
    OriGene Protein Over-expression Lysate for KMO
    OriGene MassSpec for KMO 
    OriGene Custom Protein Services for KMO
    GenScript Custom Purified and Recombinant Proteins Services for KMO
    Novus Biologicals KMO Protein
    Novus Biologicals KMO Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KMO 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane ISS10672018
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005829cytosol TAS--
    GO:0016021integral to membrane IEA--

    KMO for ontologies           About GeneDecksing



    KMO Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KMO
    GenScript Custom Superior Antibodies Services for KMO
    Novus Biologicals KMO Antibodies
    Abcam antibodies for KMO
    Cloud-Clone Corp. Antibodies for KMO 
    Search ThermoFisher Antibodies for KMO
    LSBio Antibodies in human, mouse, rat for KMO 

    Assay Products for KMO: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KMO
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KMO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KMO 
    Cloud-Clone Corp. CLIAs for KMO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002938 mOase_FAD-bd
     IPR027545 Kynurenine_monooxygenase
     IPR003042 Rng_hydrolase-like

    Graphical View of Domain Structure for InterPro Entry O15229

    ProtoNet protein and cluster: O15229

    UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
    Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily


    KMO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KMO_HUMAN, O15229
    Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required
    for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of
    NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic
    acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the
    gastrointestinal tract
    Catalytic activity: L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=24.1 uM for L-kynurenine; Vmax=8.5 umol/min/mg enzyme; pH
    dependence: Optimum pH is 7.5;

         Genatlas biochemistry entry for KMO:
    kynurenine 3-monooxygenase,55.8kDa,NADPH flavin monooxygenase,expressed in liver,placenta,kidney

         Enzyme Number (IUBMB): EC 1.14.13.91 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004502kynurenine 3-monooxygenase activity IDA10672018
    GO:0016174NAD(P)H oxidase activity IDA10672018
    GO:0050660flavin adenine dinucleotide binding IDA10672018
         
    KMO for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KMO:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KMO 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KMO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KMO 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KMO 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KMO
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate KMO (see all 17):
    hsa-miR-141* hsa-miR-641 hsa-miR-4325 hsa-miR-1299 hsa-miR-548c-3p hsa-miR-616 hsa-miR-4303 hsa-miR-3606
    SwitchGear 3'UTR luciferase reporter plasmidKMO 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KMO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KMO

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KMO
    Sirion Biotech Customized adenovirus for overexpression of KMO

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KMO (see all 7)
    OriGene ORF clones in mouse, rat for KMO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KMO (NM_003679)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KMO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO
    Sirion Biotech Customized lentivirus for stable overexpression of KMO 
                         Customized lentivirus expression plasmids for stable overexpression of KMO 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KMO
    Search LifeMap BioReagents cell lines for KMO
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KMO About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde0.50
    NAD biosynthesis II (from tryptophan)0.50
    tryptophan degradation III (eukaryotic)0.50
    Tryptophan catabolism0.45
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3tryptophan utilization II
    tryptophan utilization II0.70
    tryptophan utilization I0.70
    4Tryptophan metabolism
    Tryptophan metabolism0.46
    5NAD metabolism
    NAD metabolism0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KMO
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for KMO
        NAD metabolism

    5/6 BioSystems Pathways for KMO (see all 6)
        Selenium Pathway
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    NAD biosynthesis II (from tryptophan)
    tryptophan degradation III (eukaryotic)
    tryptophan utilization II

    3        Reactome Pathways for KMO
        Tryptophan catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for KMO):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3


    KMO for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KMO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/20 Interacting proteins for KMO (O152293 ENSP000003555174) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHPSP493663, ENSP000002100604I2D: score=1 STRING: ENSP00000210060
    ARFGAP1Q8N6T33I2D: score=5 
    ACAA1P091103I2D: score=1 
    ACAT1P247523I2D: score=1 
    ADSLP305663I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006569tryptophan catabolic process TAS--
    GO:0009435NAD biosynthetic process IEA--
    GO:0009651response to salt stress IDA10672018
    GO:0019441tryptophan catabolic process to kynurenine IEA--
    GO:0019674NAD metabolic process ----

    KMO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KMO for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for KMO

    Compounds for KMO available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Metyrapone11-beta hydroxylase inhibitor[54-36-4]
    DMOGProlylhydroxylase inhibitor[89464-63-1]
    Ro 61-8048Potent kynurenine 3-hydroxylase inhibitor[199666-03-0]

    9 HMDB Compounds for KMO    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydroxykynurenine3-(3-hydroxyanthraniloyl)-Alanine (see all 7)484-78-6--
    L-Kynurenine(S)-alpha,2-diamino-3-hydroxy-gamma-oxo-Benzenebutanoate (see all 15)343-65-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    Quinolinic acidpyridine-2,3-carboxylate (see all 10)89-00-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/14 Novoseek inferred chemical compound relationships for KMO gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (m-nitrobenzoyl)alanine 96 3 12354294 (1), 18954092 (1)
    kynurenine 95.5 90 8239646 (8), 18954092 (4), 9291104 (3), 15206781 (3) (see all 32)
    3-hydroxykynurenine 92 17 12354294 (3), 2321759 (1), 18954092 (1), 8239646 (1) (see all 8)
    kynurenic acid 88.6 15 15829251 (3), 12354294 (3), 11982504 (1), 15206781 (1) (see all 7)
    3-hydroxyanthranilic acid 88.4 8 9291104 (3), 16956766 (1), 11795205 (1), 10966936 (1)
    quinolinic acid 83.2 7 9291104 (3), 12354294 (1), 11795205 (1), 10966936 (1)
    flavin 68.7 10 18954092 (3), 12230548 (1), 9237672 (1)
    quinine 68.5 8 12354294 (3), 8293279 (2), 8245962 (1), 15206781 (1) (see all 5)
    indoleamine 68.4 2 11795205 (1), 12165503 (1)
    l-tryptophan 68.3 3 9291104 (2), 8417138 (1)

    Search CenterWatch for drugs/clinical trials and news about KMO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KMO gene: 
    NM_003679.4  

    Unigene Cluster for KMO:

    Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
    Hs.744065  [show with all ESTs]
    Unigene Representative Sequence: NM_003679
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366558(uc001hyy.3) ENST00000366559(uc009xgo.2 uc009xgp.3)
    ENST00000484628 ENST00000480967 ENST00000484229 ENST00000477907 ENST00000366557
    ENST00000481087 ENST00000431245 ENST00000366555

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KMO
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate KMO (see all 17):
    hsa-miR-141* hsa-miR-641 hsa-miR-4325 hsa-miR-1299 hsa-miR-548c-3p hsa-miR-616 hsa-miR-4303 hsa-miR-3606
    SwitchGear 3'UTR luciferase reporter plasmidKMO 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KMO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KMO
    Clone
    Products:
         
    OriGene clones in human, mouse for KMO (see all 7)
    OriGene ORF clones in mouse, rat for KMO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KMO (NM_003679)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KMO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO
    Sirion Biotech Customized lentivirus for stable overexpression of KMO 
                         Customized lentivirus expression plasmids for stable overexpression of KMO 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KMO
    OriGene qSTAR qPCR primer pairs in human, mouse for KMO
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KMO
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KMO
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KMO

    Additional mRNA sequence: 

    AF056032.1 AK291558.1 AK310937.1 BC005297.1 Y13153.1 

    14 DOTS entries:

    DT.95167751  DT.92437057  DT.100782603  DT.121407952  DT.40131123  DT.92437054  DT.100020104  DT.121407947 
    DT.95167750  DT.97763474  DT.40289099  DT.91788981  DT.92391534  DT.95148501 

    24/93 AceView cDNA sequences (see all 93):

    BX399335 CF528266 H47346 BM684741 AU135363 BX334999 CR593684 CR613404 
    AI261812 AA862887 CA398018 BX643377 AI262990 CR601734 BX392589 NM_003679 
    CA398019 BM930110 AI341967 H96044 AU139079 BG434602 AU135279 AI949852 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KMO (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                -     -                 -                       -                                                     -               
    SP2:                                -     -                 -                       -                                                                     
    SP3:                                -                       -                       -                                                                     
    SP4:                                                        -                                                                                             
    SP5:                                -     -     -     -     -                       -                                                                     


    ECgene alternative splicing isoforms for KMO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KMO expression in normal human tissues (normalized intensities)      KMO embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAATGT
    KMO Expression
    About this image


    KMO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Small Pre B-Cells Hematopoietic Bone Marrow
             b cells   
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
     
     Placenta (Extraembryonic Tissues)

    See KMO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KMO

    SOURCE GeneReport for Unigene cluster: Hs.744065

    UniProtKB/Swiss-Prot: KMO_HUMAN, O15229
    Tissue specificity: Highest levels in placenta and liver. Detectable in kidney

        SABiosciences Expression via Pathway-Focused PCR Array including KMO: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KMO
    OriGene qSTAR qPCR primer pairs in human, mouse for KMO
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KMO
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KMO
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KMO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KMO gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kmo1 , 5 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)1, 5 83.11(n)1
    82.46(a)1
      1 (81.60 cM)5
    982561  NM_133809.11  NP_598570.11 
     1756203815 
    chicken
    (Gallus gallus)
    Aves KMO1 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 69.23(n)
    70.51(a)
      424041  XM_421897.3  XP_421897.1 
    lizard
    (Anolis carolinensis)
    Reptilia KMO6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343645.1(186578-217872)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144292 Xenopus laevis transcribed sequence with weak similarity more 76.32(n)    BJ054972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kmo1 kynurenine 3-monooxygenase 66.52(n)
    65.68(a)
      368242  NM_001040306.2  NP_001035396.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta cn1 , 3 ommochrome biosynthesis kynurenine
    3-monooxygenase3
    cinnabar1
    45(a)3
    49.65(n)1
    44.55(a)1
      2 43E163
    357241  NM_078927.21  NP_523651.31 
    worm
    (Caenorhabditis elegans)
    Secernentea R07B7.51 , 3 Monooxygenase3
    Protein R07B7.51
    45(a)
    (best of 2)3
    53.08(n)1
    48.01(a)1
      V(12071388-12073115)3
    1796571  NM_073624.21  NP_506025.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BNA4(YBL098W)4
    BNA41
    Kynurenine 3-mono oxygenase, required for the de novo more4
    Bna4p1
    50.36(n)1
    40.1(a)1
      2(39145-40527)4
    8521791, 4  NP_009454.11, 4 


    ENSEMBL Gene Tree for KMO (if available)
    TreeFam Gene Tree for KMO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1403 SNPs in KMO are shown (see all 1403)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156503611,2
    C,F--241693499(+) AACTTC/TCGTTT 1 -- us2k10--------
    rs1146001041,2
    F--241693529(+) ATGCAT/CAAACA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs727660101,2
    --241693543(+) CTGGGC/TGCAGT 1 -- us2k10--------
    rs1822762731,2
    --241693566(+) TAATTC/TCAGCA 1 -- us2k10--------
    rs1869141911,2
    --241693590(+) AGGCGG/TGTGGA 1 -- us2k10--------
    rs1997051191,2
    --241693658(+) GAAAA-/AATAATAC 1 -- cds10--------
    rs1901475401,2
    --241693673(+) ATTAGC/GTAGGC 1 -- us2k10--------
    rs1415119611,2
    --241693766(+) TGAGCC/GGAGAT 1 -- us2k10--------
    rs1828453311,2
    --241693771(+) CGAGAC/TTGCAC 1 -- us2k10--------
    rs1883176141,2
    --241693884(+) TACTCA/CTACAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KMO (241695434 - 241758944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for KMO:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726207CNV Deletion23290073
    esv2726218CNV Deletion23290073
    esv2670654CNV Deletion23128226
    nsv525983CNV Loss19592680
    nsv873368CNV Gain21882294
    esv8534CNV Gain19470904
    nsv873371CNV Gain21882294
    nsv873372CNV Gain21882294


    Human Gene Mutation Database (HGMD): KMO
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KMO
    DNA2.0 Custom Variant and Variant Library Synthesis for KMO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603538    OMIM disorders: --

    13 diseases for KMO:    About MalaCards
    transient cerebral ischemia    pneumococcal meningitis    paroxysmal dyskinesia    huntington's disease
    ischemia    neurologic diseases    cerebritis    meningitis
    brain injury    schizophrenia    multiple sclerosis    pancreatitis
    neuronitis


    KMO for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    3 Novoseek inferred disease relationships for KMO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    transient cerebral ischemia 58.3 1 8417138 (1)
    cerebral ischemia 41.9 3 8239646 (2), 8245962 (1)
    ischemia 22.6 3 18954092 (1), 8239646 (1)

    Genetic Association Database (GAD): KMO
    Human Genome Epidemiology (HuGE) Navigator: KMO (3 documents)

    Export disorders for KMO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KMO gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with KMO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of human kynurenine 3- monooxygenase. (PubMed id 9237672)1, 2, 3, 9 Alberati-Giani D....Malherbe P. (1997)
    2. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. (PubMed id 16716206)1, 4, 9 Aoyama N....Ozaki N. (2006)
    3. Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. (PubMed id 10672018)1, 2, 9 Breton J.... Isacchi A. (2000)
    4. Follow-up examination of linkage and association to c hromosome 1q43 in multiple sclerosis. (PubMed id 19626040)1, 4 McCauley J.L....Haines J.L. (2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Endogenous kynurenines as targets for drug discovery and development. (PubMed id 12402501)1, 2 Stone T.W. and Darlington L.G. (2002)
    7. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. (PubMed id 11401433)1, 9 Halford S.... Hunt D.M. (2001)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    9. Kynurenine 3-monooxygenase polymorphisms: relevance fo r kynurenic acid synthesis in patients with schizophrenia and healthy controls. (PubMed id 21693093)1 Holtze M....Erhardt S. (2012)
    10. Downregulated kynurenine 3-monooxygenase gene express ion and enzyme activity in schizophrenia and genetic association with schizophr enia endophenotypes. (PubMed id 21727251)1 Wonodi I....Schwarcz R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8564 HGNC: 6381 AceView: KMO Ensembl:ENSG00000117009 euGenes: HUgn8564
    ECgene: KMO Kegg: 8564 H-InvDB: KMO

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KMO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KMO gene:
    Search GeneIP for patents involving KMO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for KMO (Kynurenine 3-Monooxygenase/KMO)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KMO  
     OriGene qPCR primer pairs and template standards for KMO   OriGene Protein Over-expression Lysate for KMO  
     OriGene MassSpec something-or-other for KMO   OriGene clones in human, mouse for KMO  
     OriGene qSTAR qPCR primer pairs in human, mouse for KMO   OriGene Purified Protein for KMO  
     OriGene ORF clones in mouse, rat for KMO   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KMO   OriGene Custom Protein Services for KMO  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KMO
     QIAGEN SeqTarget long-range PCR primers for resequencing KMO
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KMO
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KMO
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KMO
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KMO
     GenScript Custom Purified and Recombinant Proteins Services for KMO GenScript cDNA clones with any tag delivered in your preferred vector for KMO
     GenScript Custom Assay Services for KMO GenScript Custom Superior Antibodies Services for KMO
     GenScript Custom overexpressing Cell Line Services for KMO CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KMO promoter
     Search Chromatin IP Primers for KMO
     RT2 qPCR Primer Assay in human, mouse, rat KMO
     Search GNC Networks for KMO
     SABiosciences PCR Arrays including human, mouse, rat KMO
     Tocris compounds for KMO
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for KMO
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KMO antibodies
     KMO proteins
     KMO lysates
     Antibodies for KMO
     See all of Abcam's Antibodies, Kits and Proteins for KMO
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KMO
     Antibodies for KMO
     ELISAs for KMO
     CLIAs for KMO
     Search LifeMap BioReagents cell lines for KMO
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KMO
     SwitchGear 3'UTR luciferase reporter plasmids for KMO
     SwitchGear Promoter luciferase reporter plasmids for KMO
     Search ThermoFisher Antibodies for KMO
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KMO
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KMO
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KMO
    Customized:
     lentivirus for stable overexpression of KMO
     lentivirus expression plasmids for stable overexpression of KMO
     adenovirus for overexpression of KMO
     LSBio Antibodies in human, mouse, rat for KMO
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KMO gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4