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KLRK1 Gene

protein-coding   GIFtS: 63
GCID: GC12M010524

Killer Cell Lectin-Like Receptor Subfamily K, Member 1

(Previous name: DNA segment on chromosome 12 (unique) 2489 expressed sequence)
(Previous symbol: D12S2489E)
  See KLRK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Lectin-Like Receptor Subfamily K, Member 11 2     CD3142
D12S2489E1 2 3     KLR2
NKG2D2 3 5     NKG2-D2
NK Cell Receptor D2 3     NKG2-D Type II Integral Membrane Protein2
NKG2-D-Activating NK Receptor2 3     CD314 Antigen3
DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence1     Killer Cell Lectin-Like Receptor Subfamily K Member 13

External Ids:    HGNC: 187881   Entrez Gene: 229142   Ensembl: ENSG000002138097   OMIM: 6118175   UniProtKB: P267183   

Export aliases for KLRK1 gene to outside databases

Previous GC identifers: GC12M010416 GC12M010267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLRK1 Gene:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells
without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells
preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation
of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type
lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded
transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and
the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I
chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the
activation of NK and T cells. The surface expression of these ligands is important for the recognition of
stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the
treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream
KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. (provided by
RefSeq, Dec 2010)

GeneCards Summary for KLRK1 Gene:
KLRK1 (killer cell lectin-like receptor subfamily K, member 1) is a protein-coding gene. Diseases associated with KLRK1 include alveolar echinococcosis, and large granular lymphocyte leukemia. An important paralog of this gene is KLRC2.

UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor
for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune
surveillance exerted by T- and B-lymphocytes

Gene Wiki entry for KLRK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLRK1 gene promoter:
         SRF   SRF (504 AA)   POU2F1   POU2F1a   FOXJ2 (long isoform)   POU2F1b   FOXJ2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRK1 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2-p12.3

KLRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010524:  view genomic region     (about GC identifiers)

Start:
10,524,952 bp from pter      End:
10,544,473 bp from pter
Size:
19,522 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718 (See protein sequence)
Recommended Name: NKG2-D type II integral membrane protein  
Size: 216 amino acids; 25274 Da
Subunit: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression
Miscellaneous: Structurally distinct families of ligands for mouse and human NKG2D receptors have been
characterized. They might be orthologs
3 PDB 3D structures from and Proteopedia for KLRK1:
1HYR (3D)        1KCG (3D)        1MPU (3D)    
Secondary accessions: A8K7K5 A8K7P4 Q9NR41
Alternative splicing: 1 isoform:  P26718-1   

Explore the universe of human proteins at neXtProt for KLRK1: NX_P26718

Explore proteomics data for KLRK1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn131, Asn163, Asn202
  • Modification sites at PhosphoSitePlus

  • See KLRK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031386.2  
    ENSEMBL proteins: 
     ENSP00000240618   ENSP00000446003   ENSP00000379726  
    Reactome Protein details: P26718

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLR: Killer cell lectin-like receptors
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P26718

    ProtoNet protein and cluster: P26718

    UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with KLRK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKG2D_HUMAN, P26718
    Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor
    for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune
    surveillance exerted by T- and B-lymphocytes

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding ----
    GO:0032394MHC class Ib receptor activity ----
    GO:0042288MHC class I protein binding ----
         
    Find genes that share ontologies with KLRK1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klrk1):
     hematopoietic system  immune system  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with KLRK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KLRK1: Klrk1tm1Dhr Klrk1tm1.1Bpol

       genOway: Develop your customized and physiologically relevant rodent model for KLRK1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NKG2D_HUMAN, P26718: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane ----
    GO:0009897external side of plasma membrane ----
    GO:0009986cell surface ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with KLRK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLRK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    DAP12 signaling0.89
    DAP12 interactions0.89
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31
    4Malaria
    Malaria
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with KLRK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for KLRK1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    DAP12 interactions
    DAP12 signaling


    2 Kegg Pathways  (Kegg details for KLRK1):
        Natural killer cell mediated cytotoxicity
    Malaria

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLRK1
    Interactions:

        GeneGlobe Interaction Network for KLRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for KLRK1 (P267181, 2, 3 ENSP000002406184) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235233Q299831, 2, 3, ENSP000004021344EBI-458344,EBI-1031130 MINT-8214603 I2D: score=4 STRING: ENSP00000402134
    ENSG00000183214Q299831, 2, 3EBI-458344,EBI-1031130 MINT-8214603 I2D: score=4 
    MICAQ299831, 2, 3EBI-458344,EBI-1031130 MINT-8214603 I2D: score=4 
    ENSG00000231179Q299803, ENSP000004075614I2D: score=2 STRING: ENSP00000407561
    MICBQ299803, ENSP000002522294I2D: score=2 STRING: ENSP00000252229
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002223stimulatory C-type lectin receptor signaling pathway ----
    GO:0007165signal transduction ----
    GO:0030101natural killer cell activation ----
    GO:0031295T cell costimulation ----
    GO:0032729positive regulation of interferon-gamma production ----

    Find genes that share ontologies with KLRK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for KLRK1 (NKG2D)

    8 Novoseek inferred chemical compound relationships for KLRK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 48.1 1 19111017 (1)
    retinoic acid 44.1 12 16314433 (1), 17470428 (1), 19151770 (1), 14508119 (1) (see all 10)
    inosine monophosphate 18.7 1 17312110 (1)
    calcium 4.34 1 15368084 (1)
    oxygen 1.86 2 19155520 (1), 16371024 (1)
    phosphatidylinositol 0 3 20386467 (2), 15048706 (1)
    arginine 0 2 15894612 (2)
    imatinib 0 4 16393970 (2), 16585609 (1)



    Find genes that share compounds with KLRK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLRK1 gene: 
    NM_007360.3  

    Unigene Cluster for KLRK1:

    Killer cell lectin-like receptor subfamily K, member 1
    Hs.387787  [show with all ESTs]
    Unigene Representative Sequence: NM_001199805
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240618 ENST00000540267 ENST00000544449 ENST00000540818 ENST00000396451

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    Additional mRNA sequence: 

    AF260135.1 AF260136.1 AK292059.1 BC039836.1 

    6 DOTS entries:

    DT.91722276  DT.95112693  DT.442478  DT.91722292  DT.91722291  DT.95164802 

    Selected AceView cDNA sequences (see all 84):

    BC017784 AF260135 CB241686 AA361092 CR597595 CR607215 BM456777 CB216677 
    AF439512 BX489639 BM740579 U96845 BE543391 BE208303 BG392353 BI333629 
    BI253358 BX099329 BX335357 AF350018 BI765191 BQ005357 AA292938 BC039836 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTTCTC
    KLRK1 Expression
    About this image


    KLRK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             T-Cytotoxic Cells Peripheral Blood
             Natural killer-like cells
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
    KLRK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLRK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387787

    UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
    Tissue specificity: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated
    PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer
    dendritic cells (IKDCs)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLRK1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrk15 killer cell lectin-like receptor subfamily K, member more   --   6 (63.44 cM) 129610323 


    ENSEMBL Gene Tree for KLRK1 (if available)
    TreeFam Gene Tree for KLRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLRK1 gene
    KLRC4-KLRK11 2  KLRC22  KLRD12  KLRC42  ENSG000002556412  KLRC12  KLRC32  
    10 SIMAP similar genes for KLRK1 using alignment to 4 protein entries:     NKG2D_HUMAN (see all proteins):
    NKG2D    FCER2    CLEC12A    CLEC1A    KLRC2    KLRC3
    CLEC12B    KLRD1    CLEC2B    KLRC1

    Find genes that share paralogs with KLRK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLRK1 (see all 400)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39836161,2
    C,F--10397513(+) TATCTT/ATCTCA 1 -- ds50014Minor allele frequency- A:0.50NA WA 8
    rs1856421371,2
    --10397746(+) TCTGCA/GGGAAG 1 -- ds50010--------
    rs175491241,2
    F--10397797(+) GTCCTA/GTTTCT 1 -- ds50011Minor allele frequency- G:0.02NA 120
    rs79789621,2
    C,F,A,H--10397800(+) ctattC/Tcttta 1 -- ds500127Minor allele frequency- T:0.21NS EA NA WA CSA 2417
    rs1389268571,2
    --10397812(+) GACACC/TGGGGA 1 -- ds50010--------
    rs1899606531,2
    --10397896(+) AGTCCA/GAAATC 1 -- ds50010--------
    rs79759961,2
    C,F,A,H--10397899(+) ccaaaG/Atctta 1 -- ds500123Minor allele frequency- A:0.28NS EA NA CSA WA 2355
    rs1828341131,2
    --10397985(+) TGAACC/GTGTGA 1 -- ut310--------
    rs115535901,2
    C,F--10398181(-) TGCCCC/TAGTGG 1 -- ut317Minor allele frequency- T:0.14NA WA EA 366
    rs1386203131,2
    --10398216(+) GTGGAA/GGACCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLRK1 (10524952 - 10544473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KLRK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898759CNV Loss21882294
    dgv1370n71CNV Loss21882294
    nsv898763CNV Loss21882294
    dgv1371n71CNV Loss21882294
    nsv8914CNV Loss18304495
    nsv832328CNV Gain17160897
    nsv898757CNV Gain21882294

    Human Gene Mutation Database (HGMD): KLRK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for KLRK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611817    OMIM disorders: --

    7 diseases for KLRK1:    
    About MalaCards
    alveolar echinococcosis    large granular lymphocyte leukemia    t-cell large granular lymphocyte leukemia    tropical spastic paraparesis
    tongue cancer    spastic paraparesis    primary sclerosing cholangitis

    1 disease from the University of Copenhagen DISEASES database for KLRK1:
    Leukemia

    Find genes that share disorders with KLRK1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KLRK1 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 52.3 194 18334111 (5), 17911639 (4), 15545356 (4), 17470428 (3) (see all 81)
    celiac disease 43.8 3 19237603 (2), 20061825 (1)
    cancer 43.3 68 17661204 (4), 18490724 (4), 17255258 (4), 18463537 (4) (see all 28)
    epithelial tumor 41.1 2 18672004 (1), 10574749 (1)
    autoimmune diseases 37.2 9 18486757 (1), 18602338 (1), 18361934 (1), 15490153 (1) (see all 8)
    nasopharyngeal carcinoma 30.7 3 17584663 (2), 19620045 (1)
    myeloma 27.3 22 18599182 (4), 17875681 (4), 19748980 (2), 20024547 (1) (see all 6)
    melanoma 23.5 11 18094430 (2), 11298332 (1), 17911639 (1), 16342232 (1) (see all 7)
    gastrointestinal tumor 21.8 4 17661204 (2)
    virus infection 20.2 2 18361934 (1), 19508374 (1)

    Genetic Association Database (GAD): KLRK1
    Human Genome Epidemiology (HuGE) Navigator: KLRK1 (10 documents)

    Export disorders for KLRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KLRK1 gene, integrated from 10 sources (see all 434):
    (articles sorted by number of sources associating them with KLRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PubMed id 9683661)1, 2, 3 Glienke J.... Francis F. (Immunogenetics 1998)
    2. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PubMed id 2007850)1, 2, 3 Houchins J.P.... Bach F.H. (J. Exp. Med. 1991)
    3. Association of an NKG2D gene variant with systemic lupus erythematosus in two populations. (PubMed id 19735685)1, 4, 9 Kabalak G....Witte T. (Hum. Immunol. 2010)
    4. Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. (PubMed id 12679019)1, 2, 9 McFarland B.J.... Strong R.K. (Structure 2003)
    5. Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. (PubMed id 18174257)1, 4, 9 Furue H....Tajima K. (Carcinogenesis 2008)
    6. Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms. (PubMed id 18023027)1, 4, 9 Melum E....Lie B.A. (Hepatology 2008)
    7. Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? (PubMed id 11973127)1, 2, 9 Vivier E.... Paul P. (Curr. Opin. Immunol. 2002)
    8. Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis. (PubMed id 18361934)1, 4, 9 Garrido P....Ruiz-Cabello F. (Hum. Immunol. 2008)
    9. Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population. (PubMed id 20648603)1, 4 Ma J....Liu Y. (J. Med. Virol. 2010)
    10. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 22914 HGNC: 18788 AceView: KLRK1 Ensembl:ENSG00000213809 euGenes: HUgn22914
    ECgene: KLRK1 Kegg: 22914 H-InvDB: KLRK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLRK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLRK1 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_246

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLRK1 gene:
    Search GeneIP for patents involving KLRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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