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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLRK1 Gene

protein-coding   GIFtS: 59
GCID: GC12M010524

killer cell lectin-like receptor subfamily K, member 1

(Previous name: DNA segment on chromosome 12 (unique) 2489 expressed sequence...)
(Previous symbol: D12S2489E)
 Explore 82 diseases affiliated with
KLRK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLRK1    

Aliases
for KLRK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Killer Cell Lectin-Like Receptor Subfamily K, Member 11 2     NK Cell Receptor D2 3
NKG2D1 2 3 5     NKG2-D-Activating NK Receptor2 3
D12S2489E1 2 3     DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence1
CD3141 2     NKG2-D Type II Integral Membrane Protein2
KLR1 2     CD314 Antigen3
NKG2-D1 2     Killer Cell Lectin-Like Receptor Subfamily K Member 13

External Ids:    HGNC: 187881   Entrez Gene: 229142   Ensembl: ENSG000002138097   OMIM: 6118175   UniProtKB: P267183   

Export aliases for KLRK1 gene to outside databases

Previous GC identifers: GC12M010416 GC12M010267


Summaries
for KLRK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLRK1:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells
without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells
preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK
cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin
genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane
protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a
C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins
and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The
surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus
this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through
transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4)
family member in the same cluster. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for
the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune
surveillance exerted by T- and B-lymphocytes

Gene Wiki entry for KLRK1


Genomic Views
for KLRK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLRK1 gene promoter:
         SRF   SRF (504 AA)   POU2F1   POU2F1a   FOXJ2 (long isoform)   POU2F1b   FOXJ2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLRK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLRK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2-p12.3

KLRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010524:  view genomic region     (about GC identifiers)

Start:
 10,524,952 bp from pter      End:
 10,544,473 bp from pter
Size:
 19,522 bases      Orientation:
 minus strand

Proteins
for KLRK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718 (See protein sequence)
Recommended Name: NKG2-D type II integral membrane protein  
Size: 216 amino acids; 25274 Da
Subunit: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression
Subcellular location: Membrane; Single-pass type II membrane protein
Miscellaneous: Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized.
They might be orthologs
3 PDB 3D structures from and Proteopedia for KLRK1:
1HYR (3D)        1KCG (3D)        1MPU (3D)    
Secondary accessions: A8K7K5 A8K7P4 Q9NR41
Alternative splicing: 1 isoform:  P26718-1   

Explore the universe of human proteins at neXtProt for KLRK1: NX_P26718

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26718

    • KLRK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031386.2  
    ENSEMBL proteins: 
     ENSP00000240618   ENSP00000446003   ENSP00000379726  
    Reactome Protein details: P26718
    Human Recombinant Protein Products: 
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    Uscn Proteins for KLRK1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane ----
    GO:0009897external side of plasma membrane ----
    GO:0009986cell surface ----
    GO:0016021integral to membrane ----


    KLRK1 for ontologies           About GeneDecksing



    KLRK1 Antibody Products: 
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    ThermoFisher Antibodies for KLRK1

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    Uscn ELISAs and CLIAs for KLRK1

    Protein Domains /
    Families
    for KLRK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLRK1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P26718

    ProtoNet protein and cluster: P26718

    UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
    Similarity: Contains 1 C-type lectin domain


    Function
    for KLRK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
    Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for
    the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune
    surveillance exerted by T- and B-lymphocytes

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for KLRK1

    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding ----
    GO:0032394MHC class Ib receptor activity ----
    GO:0042288MHC class I protein binding ----


    KLRK1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for KLRK1: Klrk1tm1Dhr Klrk1tm1.1Bpol
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Klrk1):
     cellular  hematopoietic system  immune system  mortality/aging  tumorigenesis 

    KLRK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KLRK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    2Signaling by FGFR
    		DAP12 signaling0.83
    		DAP12 interactions0.76
    3Natural killer cell mediated cytotoxicity
    		Natural killer cell mediated cytotoxicity1.00
    4Malaria
    		Malaria1.00
    5Cleavage of Alpha-1-Microglobulin
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for KLRK1 (see all 6)
        DAP12 interactions
    DAP12 signaling
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for KLRK1):
        Natural killer cell mediated cytotoxicity
    Malaria


    KLRK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/18 Interacting proteins for KLRK1 (P267182, 3 ENSP000002406184) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MICAQ299832, 3MINT-8214603 I2D: score=4 
    TYROBPO439143, ENSP000002626294I2D: score=3 STRING: ENSP00000262629
    MICBQ299803, ENSP000002522294I2D: score=2 STRING: ENSP00000252229
    RAE1P784063, ENSP000003602864I2D: score=1 STRING: ENSP00000360286
    HCSTQ9UBK53, ENSP000002465514I2D: score=4 STRING: ENSP00000246551
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002223stimulatory C-type lectin receptor signaling pathway ----
    GO:0007165signal transduction ----
    GO:0030101natural killer cell activation ----
    GO:0031295T cell costimulation ----
    GO:0032729positive regulation of interferon-gamma production ----


    KLRK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLRK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLRK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLRK1
    8 Novoseek chemical compound relationships for KLRK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 48.1 1 19111017 (1)
    retinoic acid 44.1 12 16314433 (1), 17470428 (1), 19151770 (1), 14508119 (1) (see all 10)
    inosine monophosphate 18.7 1 17312110 (1)
    calcium 4.34 1 15368084 (1)
    oxygen 1.86 2 19155520 (1), 16371024 (1)
    phosphatidylinositol 0 3 20386467 (2), 15048706 (1)
    arginine 0 2 15894612 (2)
    imatinib 0 4 16393970 (2), 16585609 (1)

    Search CenterWatch for drugs/clinical trials and news about KLRK1 / NKG2D 

    Transcripts
    for KLRK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLRK1 gene: 
    NM_007360.3  

    Unigene Cluster for KLRK1:

    Killer cell lectin-like receptor subfamily K, member 1
    Hs.387787  [show with all ESTs]
    Unigene Representative Sequence: NM_001199805
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240618 ENST00000540267 ENST00000544449 ENST00000540818 ENST00000396451


    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: KLRK1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF260135.1 AF260136.1 AK292059.1 BC039836.1 

    6 DOTS entries:

    DT.91722276  DT.95112693  DT.442478  DT.91722292  DT.91722291  DT.95164802 

    24/84 AceView cDNA sequences (see all 84):

    CB241686 AA361092 AF260135 BC017784 CR597595 CR607215 CB216677 AF439512 
    BM456777 BG485675 BI909601 BG392353 U96845 AF350019 AA766117 AF461811 
    BI253358 BE208303 BE543391 BG682117 AA292938 BX099329 BC039836 BM740579 

    GeneLoc Exon Structure


    Expression
    for KLRK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGTTTCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KLRK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Natural killer-like cells (Derivation of hemato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KLRK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLRK1

    SOURCE GeneReport for Unigene cluster: Hs.387787

    UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
    Tissue specificity: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC.
    Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic
    cells (IKDCs)

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    In Situ
    Assay Products:     
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    Orthologs
    for KLRK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KLRK1 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia CLEC9A6
    		 --
    		 26(a)
    		 1 → many
    		 2(81818136-81823316)


    ENSEMBL Gene Tree for KLRK1 (if available)
    TreeFam Gene Tree for KLRK1 (if available) 

    Paralogs
    for KLRK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLRK1 gene
    KLRC4-KLRK1  OLR12  CLEC9A2  KLRC22  ENSG000002558192  CLEC12A2  CLEC1A2  KLRC32  
    KLRD12  KLRC42  CLEC1B2  ENSG000002556412  CLEC7A2  KLRC12  CLEC12B2  
    11 SIMAP similar genes for KLRK1 using alignment to 8 protein entries:     NKG2D_HUMAN (see all proteins):
    KLRC4    NKG2D    KLRC1    KLRC2    FCER2    KLRC3
    CLEC12A    CLEC1A    CLEC12B    CLEC2B    KLRD1

    KLRK1 for paralogs           About GeneDecksing



    Genomic Variants
    for KLRK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/316 NCBI SNPs in KLRK1 are shown (see all 316)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs175491241,2
    		F,--10267248(+) GTCCTA/GTTTCT 1 -- ds50011Minor allele frequency- G:0.02NA 120
    rs115535901,2
    		C,F,--10267636(-) NNNNCC/TAGTGG 1 -- ut317Minor allele frequency- T:0.14NA WA EA 366
    rs1126826811,2
    		--10267783(+) GGGTTC/GCACTC 1 -- ut311Minor allele frequency- G:0.33CSA 3
    rs175491101,2
    		C,F,--10267917(+) TTGGGG/AATATC 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs20617551,2
    		C,F,--10267924(-) CAATTC/GAGATA 1 -- ut316Minor allele frequency- G:0.08NA WA 262
    rs20617541,2
    		C,F,H,--10267928(-) AAGGCA/GATTCA 1 -- ut3110Minor allele frequency- G:0.06NA NS EA WA CSA 569
    rs732562461,2
    		C,--10268626(+) TAAAAC/TATTTT 1 -- int15Minor allele frequency- T:0.34WA CSA 125
    rs1116283151,2
    		--10269294(+) TCCCAA/C/GAGTGC 1 -- int11CSA 2
    rs118341721,2
    		C,F,A,H,--10269339(+) CAGCTG/TAGATT 1 -- int18Minor allele frequency- T:0.15NS EA WA NA 542
    rs118346631,2
    		C,F,A,H,--10269452(+) tgtcaG/Cccagg 1 -- int14Minor allele frequency- C:0.40NA WA 10

    HapMap Linkage Disequilibrium report for KLRK1 (10524952 - 10544473 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLRK1: --
    Human Gene Mutation Database (HGMD): KLRK1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for KLRK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLRK1 for disorders           About GeneDecksing

    OMIM gene information: 611817    OMIM disorders: --

    20/82 diseases for KLRK1 (see all 82):    About MalaCards
    mhc class i deficiency    relapsing-remitting multiple sclerosis    paroxysmal nocturnal hemoglobinuria    human t-cell leukemia virus type 1
    hypersensitivity reaction type ii disease    graft versus host disease    sclerosing cholangitis    primary sclerosing cholangitis
    nonalcoholic steatohepatitis    alveolar echinococcosis    type 1 diabetes mellitus    alopecia areata
    wegener's granulomatosis    lupus erythematosus    idiopathic pulmonary fibrosis    echinococcosis
    cholangitis    hemoglobinuria    oral squamous cell carcinoma    multiple sclerosis

    1 disease from the University of Copenhagen DISEASES database for KLRK1:
    Leukemia

    10/32 Novoseek disease relationships for KLRK1 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 52.3 194 18334111 (5), 17911639 (4), 15545356 (4), 17470428 (3) (see all 81)
    celiac disease 43.8 3 19237603 (2), 20061825 (1)
    cancer 43.3 68 17661204 (4), 18490724 (4), 17255258 (4), 18463537 (4) (see all 28)
    epithelial tumor 41.1 2 18672004 (1), 10574749 (1)
    autoimmune diseases 37.2 9 18486757 (1), 18602338 (1), 18361934 (1), 15490153 (1) (see all 8)
    nasopharyngeal carcinoma 30.7 3 17584663 (2), 19620045 (1)
    myeloma 27.3 22 18599182 (4), 17875681 (4), 19748980 (2), 20024547 (1) (see all 6)
    melanoma 23.5 11 18094430 (2), 11298332 (1), 17911639 (1), 16342232 (1) (see all 7)
    gastrointestinal tumor 21.8 4 17661204 (2)
    virus infection 20.2 2 18361934 (1), 19508374 (1)

    Human Genome Epidemiology (HuGE) Navigator: KLRK1 (10 documents)

    Export disorders for KLRK1 gene to outside databases

    Publications
    for KLRK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLRK1 gene, integrated from 9 sources (see all 417):
    (articles sorted by number of sources associating them with KLRK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PubMed id 9683661)1, 2, 3 Glienke J.... Francis F. (1998)
    2. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PubMed id 2007850)1, 2, 3 Houchins J.P....Bach F.H. (1991)
    3. Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. (PubMed id 12679019)1, 2, 9 McFarland B.J.... Strong R.K. (2003)
    4. Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? (PubMed id 11973127)1, 2, 9 Vivier E.... Paul P. (2002)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PubMed id 11751968)1, 2 Shum B.P.... Parham P. (2002)
    7. Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. (PubMed id 11754823)1, 2 Radaev S.... Sun P.D. (2001)
    8. Activation of NK cells and T cells by NKG2D, a receptor for stress- inducible MICA. (PubMed id 10426993)1, 2 Bauer S....Spies T. (1999)
    9. Reduced immune effector cell NKG2D expression and inc reased levels of soluble NKG2D ligands in multiple myeloma may not be causally linked. (PubMed id 20024547)1, 9 von Lilienfeld-Toal M....Cook G. (2010)
    10. 4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells. (PubMed id 18024793)1, 9 Kim Y.J....Broxmeyer H.E. (2008)

    External Searches for KLRK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KLRK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22914 HGNC: 18788 AceView: KLRK1 Ensembl:ENSG00000213809 euGenes: HUgn22914
    ECgene: KLRK1 Kegg: 22914 H-InvDB: KLRK1

    Other Databases showing KLRK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLRK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLRK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLRK1 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_246

    Intellectual Property
    for KLRK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLRK1 gene:
    Search GeneIP for patents involving KLRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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