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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLRK1 Gene

protein-coding   GIFtS: 62
GCID: GC12M010524

Killer Cell Lectin-Like Receptor Subfamily K, Member 1

(Previous name: DNA segment on chromosome 12 (unique) 2489 expressed sequence)
(Previous symbol: D12S2489E)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Lectin-Like Receptor Subfamily K, Member 11 2     CD3142
D12S2489E1 2 3     KLR2
NKG2D2 3 5     NKG2-D2
NK Cell Receptor D2 3     NKG2-D Type II Integral Membrane Protein2
NKG2-D-Activating NK Receptor2 3     CD314 Antigen3
DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence1     Killer Cell Lectin-Like Receptor Subfamily K Member 13

External Ids:    HGNC: 187881   Entrez Gene: 229142   Ensembl: ENSG000002138097   OMIM: 6118175   UniProtKB: P267183   

Export aliases for KLRK1 gene to outside databases

Previous GC identifers: GC12M010416 GC12M010267


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLRK1 Gene:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells
without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells
preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation
of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type
lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded
transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and
the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I
chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the
activation of NK and T cells. The surface expression of these ligands is important for the recognition of
stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the
treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream
KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. (provided by
RefSeq, Dec 2010)

GeneCards Summary for KLRK1 Gene: 
KLRK1 (killer cell lectin-like receptor subfamily K, member 1) is a protein-coding gene. Diseases associated with KLRK1 include mhc class i deficiency, and alveolar echinococcosis, and among its related super-pathways are Immune System and DAP12 interactions. An important paralog of this gene is KLRC2.

UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor
for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune
surveillance exerted by T- and B-lymphocytes

Gene Wiki entry for KLRK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLRK1 gene promoter:
         SRF   SRF (504 AA)   POU2F1   POU2F1a   FOXJ2 (long isoform)   POU2F1b   FOXJ2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLRK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2-p12.3

KLRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010524:  view genomic region     (about GC identifiers)

Start:
10,524,952 bp from pter      End:
10,544,473 bp from pter
Size:
19,522 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718 (See protein sequence)
Recommended Name: NKG2-D type II integral membrane protein  
Size: 216 amino acids; 25274 Da
Subunit: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression
Subcellular location: Membrane; Single-pass type II membrane protein
Miscellaneous: Structurally distinct families of ligands for mouse and human NKG2D receptors have been
characterized. They might be orthologs
3 PDB 3D structures from and Proteopedia for KLRK1:
1HYR (3D)        1KCG (3D)        1MPU (3D)    
Secondary accessions: A8K7K5 A8K7P4 Q9NR41
Alternative splicing: 1 isoform:  P26718-1   

Explore the universe of human proteins at neXtProt for KLRK1: NX_P26718

Explore proteomics data for KLRK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26718

  • KLRK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLRK1 Protein Expression
    REFSEQ proteins: NP_031386.2  
    ENSEMBL proteins: 
     ENSP00000240618   ENSP00000446003   ENSP00000379726  
    Reactome Protein details: P26718
    Human Recombinant Protein Products for KLRK1: 
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    ProSpec Recombinant Protein for KLRK1
    Cloud-Clone Corp. Proteins for KLRK1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane ----
    GO:0009897external side of plasma membrane ----
    GO:0009986cell surface ----
    GO:0016021integral to membrane ----

    KLRK1 for ontologies           About GeneDecksing



    KLRK1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for KLRK1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KLR: Killer cell lectin-like receptors
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P26718

    ProtoNet protein and cluster: P26718

    UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
    Similarity: Contains 1 C-type lectin domain


    KLRK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKG2D_HUMAN, P26718
    Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor
    for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune
    surveillance exerted by T- and B-lymphocytes

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding ----
    GO:0032394MHC class Ib receptor activity ----
    GO:0042288MHC class I protein binding ----
         
    KLRK1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klrk1):
     cellular  hematopoietic system  immune system  mortality/aging  tumorigenesis 

    KLRK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KLRK1: Klrk1tm1Dhr Klrk1tm1.1Bpol

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLRK1 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLRK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    2Signaling by FGFR
    DAP12 signaling0.91
    DAP12 interactions0.91
    3Immune response Fc epsilon RI pathway
    Natural killer cell mediated cytotoxicity0.31
    4Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
    5Malaria
    Malaria

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for KLRK1 (see all 6)
        DAP12 interactions
    DAP12 signaling
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for KLRK1):
        Natural killer cell mediated cytotoxicity
    Malaria


    KLRK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/24 Interacting proteins for KLRK1 (P267182, 3 ENSP000002406184) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235233Q299832, 3, ENSP000004021344MINT-8214603 I2D: score=4 STRING: ENSP00000402134
    ENSG00000183214Q299832, 3MINT-8214603 I2D: score=4 
    MICAQ299832, 3MINT-8214603 I2D: score=4 
    ENSG00000231179Q299803, ENSP000004075614I2D: score=2 STRING: ENSP00000407561
    MICBQ299803, ENSP000002522294I2D: score=2 STRING: ENSP00000252229
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002223stimulatory C-type lectin receptor signaling pathway ----
    GO:0007165signal transduction ----
    GO:0030101natural killer cell activation ----
    GO:0031295T cell costimulation ----
    GO:0032729positive regulation of interferon-gamma production ----

    KLRK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLRK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLRK1 (NKG2D)

    8 Novoseek inferred chemical compound relationships for KLRK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 48.1 1 19111017 (1)
    retinoic acid 44.1 12 16314433 (1), 17470428 (1), 19151770 (1), 14508119 (1) (see all 10)
    inosine monophosphate 18.7 1 17312110 (1)
    calcium 4.34 1 15368084 (1)
    oxygen 1.86 2 19155520 (1), 16371024 (1)
    phosphatidylinositol 0 3 20386467 (2), 15048706 (1)
    arginine 0 2 15894612 (2)
    imatinib 0 4 16393970 (2), 16585609 (1)

    Search CenterWatch for drugs/clinical trials and news about KLRK1 / NKG2D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLRK1 gene: 
    NM_007360.3  

    Unigene Cluster for KLRK1:

    Killer cell lectin-like receptor subfamily K, member 1
    Hs.387787  [show with all ESTs]
    Unigene Representative Sequence: NM_001199805
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240618 ENST00000540267 ENST00000544449 ENST00000540818 ENST00000396451

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF260135.1 AF260136.1 AK292059.1 BC039836.1 

    6 DOTS entries:

    DT.91722276  DT.95112693  DT.442478  DT.91722292  DT.91722291  DT.95164802 

    24/84 AceView cDNA sequences (see all 84):

    CR597595 AF260135 CB216677 CR607215 AA361092 BC017784 AF439512 BM456777 
    CB241686 BX489639 BE301422 BG485675 BQ005357 AF461811 U96845 BI333629 
    AF350018 BQ708055 AW404105 BX099329 AA766117 BI909601 BI765191 BC039836 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLRK1 expression in normal human tissues (normalized intensities)      KLRK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTTCTC
    KLRK1 Expression
    About this image


    KLRK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Natural Killer Cells Peripheral Blood
             Natural killer-like cells ( Derivation of hematopoietic progenitor cells and natural...
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Uterus (Reproductive System)
             CERVIX   

    See KLRK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLRK1

    SOURCE GeneReport for Unigene cluster: Hs.387787

    UniProtKB/Swiss-Prot: NKG2D_HUMAN, P26718
    Tissue specificity: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated
    PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer
    dendritic cells (IKDCs)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLRK1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrk11 , 5 killer cell lectin-like receptor subfamily K, member more1, 5 71.32(n)1
    60(a)1
      6 (63.44 cM)5
    270071  NM_033078.31  NP_149069.11 
     1296103235 
    lizard
    (Anolis carolinensis)
    Reptilia KLRK16
    killer cell lectin-like receptor subfamily K, memb...
    23(a)
    1 ↔ 1
    2(81818136-81823316)


    ENSEMBL Gene Tree for KLRK1 (if available)
    TreeFam Gene Tree for KLRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLRK1 gene
    KLRC4-KLRK11 2  KLRC22  KLRD12  KLRC42  ENSG000002556412  KLRC12  KLRC32  
    10 SIMAP similar genes for KLRK1 using alignment to 8 protein entries:     NKG2D_HUMAN (see all proteins):
    KLRC4    NKG2D    KLRC1    KLRC2    FCER2    KLRC3
    CLEC12A    CLEC1A    CLEC12B    CLEC2B

    KLRK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/400 SNPs in KLRK1 are shown (see all 400)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39836161,2
    C,F--10397513(+) TATCTT/ATCTCA 1 -- ds50014Minor allele frequency- A:0.50NA WA 8
    rs1856421371,2
    --10397746(+) TCTGCA/GGGAAG 1 -- ds50010--------
    rs175491241,2
    F--10397797(+) GTCCTA/GTTTCT 1 -- ds50011Minor allele frequency- G:0.02NA 120
    rs79789621,2
    C,F,A,H--10397800(+) ctattC/Tcttta 1 -- ds500127Minor allele frequency- T:0.21NS EA NA WA CSA 2417
    rs1389268571,2
    --10397812(+) GACACC/TGGGGA 1 -- ds50010--------
    rs1899606531,2
    --10397896(+) AGTCCA/GAAATC 1 -- ds50010--------
    rs79759961,2
    C,F,A,H--10397899(+) ccaaaG/Atctta 1 -- ds500123Minor allele frequency- A:0.28NS EA NA CSA WA 2355
    rs1828341131,2
    --10397985(+) TGAACC/GTGTGA 1 -- ut310--------
    rs115535901,2
    C,F--10398181(-) TGCCCC/TAGTGG 1 -- ut317Minor allele frequency- T:0.14NA WA EA 366
    rs1386203131,2
    --10398216(+) GTGGAA/GGACCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLRK1 (10524952 - 10544473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KLRK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898759CNV Loss21882294
    dgv1370n71CNV Loss21882294
    nsv898763CNV Loss21882294
    dgv1371n71CNV Loss21882294
    nsv8914CNV Loss18304495
    nsv832328CNV Gain17160897
    nsv898757CNV Gain21882294


    Human Gene Mutation Database (HGMD): KLRK1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for KLRK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611817    OMIM disorders: --

    20/87 diseases for KLRK1 (see all 87):    About MalaCards
    mhc class i deficiency    alveolar echinococcosis    paroxysmal nocturnal hemoglobinuria    tongue cancer
    echinococcosis    relapsing-remitting multiple sclerosis    htlv-1 associated myelopathy/tropical spastic paraparesis    nonalcoholic steatohepatitis
    primary sclerosing cholangitis    sclerosing cholangitis    htlv-1 associated myelopathy    hemoglobinuria
    alopecia areata    nasopharyngitis    celiac disease    hypersensitivity reaction type ii disease
    cholangitis    churg-strauss syndrome    acute graft versus host disease    myeloma

    1 disease from the University of Copenhagen DISEASES database for KLRK1:
    Leukemia

    KLRK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/32 Novoseek inferred disease relationships for KLRK1 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 52.3 194 18334111 (5), 17911639 (4), 15545356 (4), 17470428 (3) (see all 81)
    celiac disease 43.8 3 19237603 (2), 20061825 (1)
    cancer 43.3 68 17661204 (4), 18490724 (4), 17255258 (4), 18463537 (4) (see all 28)
    epithelial tumor 41.1 2 18672004 (1), 10574749 (1)
    autoimmune diseases 37.2 9 18486757 (1), 18602338 (1), 18361934 (1), 15490153 (1) (see all 8)
    nasopharyngeal carcinoma 30.7 3 17584663 (2), 19620045 (1)
    myeloma 27.3 22 18599182 (4), 17875681 (4), 19748980 (2), 20024547 (1) (see all 6)
    melanoma 23.5 11 18094430 (2), 11298332 (1), 17911639 (1), 16342232 (1) (see all 7)
    gastrointestinal tumor 21.8 4 17661204 (2)
    virus infection 20.2 2 18361934 (1), 19508374 (1)

    Genetic Association Database (GAD): KLRK1
    Human Genome Epidemiology (HuGE) Navigator: KLRK1 (10 documents)

    Export disorders for KLRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLRK1 gene, integrated from 9 sources (see all 429):
    (articles sorted by number of sources associating them with KLRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PubMed id 9683661)1, 2, 3 Glienke J.... Francis F. (1998)
    2. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PubMed id 2007850)1, 2, 3 Houchins J.P....Bach F.H. (1991)
    3. Association of an NKG2D gene variant with systemic lu pus erythematosus in two populations. (PubMed id 19735685)1, 4, 9 Kabalak G....Witte T. (2010)
    4. Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. (PubMed id 12679019)1, 2, 9 McFarland B.J.... Strong R.K. (2003)
    5. Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. (PubMed id 18174257)1, 4, 9 Furue H....Tajima K. (2008)
    6. Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms. (PubMed id 18023027)1, 4, 9 Melum E....Lie B.A. (2008)
    7. Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? (PubMed id 11973127)1, 2, 9 Vivier E.... Paul P. (2002)
    8. Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis. (PubMed id 18361934)1, 4, 9 Garrido P....Ruiz-Cabello F. (2008)
    9. Association of NKG2D genetic polymorphism with suscep tibility to chronic hepatitis B in a Han Chinese population. (PubMed id 20648603)1, 4 Ma J....Liu Y. (2010)
    10. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22914 HGNC: 18788 AceView: KLRK1 Ensembl:ENSG00000213809 euGenes: HUgn22914
    ECgene: KLRK1 Kegg: 22914 H-InvDB: KLRK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLRK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLRK1 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_246

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLRK1 gene:
    Search GeneIP for patents involving KLRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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