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Aliases for KLRG2 Gene

Aliases for KLRG2 Gene

  • Killer Cell Lectin Like Receptor G2 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily G, Member 2 2 3
  • C-Type Lectin Domain Family 15 Member B 3 4
  • CLEC15B 3 4
  • Killer Cell Lectin-Like Receptor Subfamily G Member 2 3
  • C-Type Lectin Domain Family 15, Member B 2

External Ids for KLRG2 Gene

Previous GeneCards Identifiers for KLRG2 Gene

  • GC07M138787
  • GC07M139137
  • GC07M133447

Summaries for KLRG2 Gene

GeneCards Summary for KLRG2 Gene

KLRG2 (Killer Cell Lectin Like Receptor G2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC2L.

Additional gene information for KLRG2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRG2 Gene

Genomics for KLRG2 Gene

GeneHancer (GH) Regulatory Elements for KLRG2 Gene

Promoters and enhancers for KLRG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I139482 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 557.5 +0.2 210 1.8 PKNOX1 ZNF2 ZNF335 GLIS2 ZNF398 ZEB2 ZNF592 ZFP69B ATF4 GLIS1 KLRG2 TTC26 UBN2 RNU6-911P
GH07I139339 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 14.2 +142.4 142428 3.9 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D LUC7L2 FMC1 TRR-CCT4-1 GC07P139357 GC07P139356 C7orf55-LUC7L2 UBN2 ENSG00000273391 KLRG2 TTC26
GH07I139452 Enhancer 0.6 Ensembl ENCODE 12.3 +30.0 30015 1.8 SMARCA5 CTCF ATF2 KLRG2 ENSG00000273391 RNU6-911P
GH07I139441 Enhancer 0.4 ENCODE 16.9 +41.4 41369 1 ADNP EGR2 ENSG00000273391 KLRG2 GC07P139433 RNU6-911P
GH07I139456 Enhancer 0.6 ENCODE 6.4 +26.2 26199 1.6 ZNF263 SMARCC1 L3MBTL2 USF2 ELF1 ZKSCAN1 MITF FOSL1 ZFHX2 CTBP1 KLRG2 RNU6-911P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLRG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLRG2 gene promoter:

Genomic Locations for KLRG2 Gene

Genomic Locations for KLRG2 Gene
56,780 bases
Minus strand

Genomic View for KLRG2 Gene

Genes around KLRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRG2 Gene

Proteins for KLRG2 Gene

  • Protein details for KLRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell lectin-like receptor subfamily G member 2
    Protein Accession:
    Secondary Accessions:
    • Q2NL79
    • Q6ZTV6

    Protein attributes for KLRG2 Gene

    409 amino acids
    Molecular mass:
    42851 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLRG2 Gene


neXtProt entry for KLRG2 Gene

Post-translational modifications for KLRG2 Gene

No Post-translational modifications

Other Protein References for KLRG2 Gene

No data available for DME Specific Peptides for KLRG2 Gene

Domains & Families for KLRG2 Gene

Gene Families for KLRG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for KLRG2 Gene

Suggested Antigen Peptide Sequences for KLRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRG2: view

No data available for UniProtKB/Swiss-Prot for KLRG2 Gene

Function for KLRG2 Gene

Phenotypes From GWAS Catalog for KLRG2 Gene

Gene Ontology (GO) - Molecular Function for KLRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRG2: view
genes like me logo Genes that share phenotypes with KLRG2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLRG2 Gene

Localization for KLRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRG2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRG2 gene
Compartment Confidence
plasma membrane 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KLRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLRG2 Gene

Pathways & Interactions for KLRG2 Gene

SuperPathways for KLRG2 Gene

No Data Available

Interacting Proteins for KLRG2 Gene

Gene Ontology (GO) - Biological Process for KLRG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLRG2 Gene

Drugs & Compounds for KLRG2 Gene

No Compound Related Data Available

Transcripts for KLRG2 Gene

mRNA/cDNA for KLRG2 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLRG2 Gene

Killer cell lectin-like receptor subfamily G, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRG2 Gene

No ASD Table

Relevant External Links for KLRG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRG2 Gene

This gene is overexpressed in Nerve - Tibial (x8.6), Esophagus - Mucosa (x8.6), Thyroid (x7.1), Minor Salivary Gland (x5.4), Skin - Sun Exposed (Lower leg) (x5.2), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for KLRG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.5), Fetal ovary (16.4), and Fetal testis (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLRG2 Gene

Protein tissue co-expression partners for KLRG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLRG2 Gene:


SOURCE GeneReport for Unigene cluster for KLRG2 Gene:


Evidence on tissue expression from TISSUES for KLRG2 Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with KLRG2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRG2 Gene

Orthologs for KLRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRG2 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia KLRG2 33
  • 82.46 (n)
-- 34
  • 50 (a)
-- 34
  • 34 (a)
(Bos Taurus)
Mammalia KLRG2 33 34
  • 78.21 (n)
(Rattus norvegicus)
Mammalia Klrg2 33
  • 72.65 (n)
(Mus musculus)
Mammalia Klrg2 33 16 34
  • 72.39 (n)
(Monodelphis domestica)
Mammalia KLRG2 34
  • 43 (a)
(Gallus gallus)
Aves KLRG2 34
  • 23 (a)
Species where no ortholog for KLRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRG2 Gene

Gene Tree for KLRG2 (if available)
Gene Tree for KLRG2 (if available)

Paralogs for KLRG2 Gene

Paralogs for KLRG2 Gene

genes like me logo Genes that share paralogs with KLRG2: view

Variants for KLRG2 Gene

Sequence variations from dbSNP and Humsavar for KLRG2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000006699 -- 139,442,696(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000022805 -- 139,443,022(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000089679 -- 139,430,775(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000117203 -- 139,483,100(-) C/G coding_sequence_variant, synonymous_variant
rs1000137855 -- 139,455,340(-) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLRG2 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
nsv526644 CNV loss 19592680
nsv526825 CNV loss 19592680

Variation tolerance for KLRG2 Gene

Gene Damage Index Score: 10.32; 90.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRG2 Gene

Disorders for KLRG2 Gene

Additional Disease Information for KLRG2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLRG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRG2 Gene

Publications for KLRG2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. (PMID: 20945404) Liu X … Witte JS (The Prostate 2011) 3 58
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for KLRG2 Gene

Sources for KLRG2 Gene

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