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Aliases for KLRG2 Gene

Aliases for KLRG2 Gene

  • Killer Cell Lectin-Like Receptor Subfamily G, Member 2 2 3
  • C-Type Lectin Domain Family 15 Member B 3 4
  • CLEC15B 3 4
  • Killer Cell Lectin-Like Receptor Subfamily G Member 2 3
  • C-Type Lectin Domain Family 15, Member B 3
  • C-Type Lectin Domain Family 15 2
  • Member B 2

External Ids for KLRG2 Gene

Previous GeneCards Identifiers for KLRG2 Gene

  • GC07M138787
  • GC07M139137
  • GC07M133447

Summaries for KLRG2 Gene

GeneCards Summary for KLRG2 Gene

KLRG2 (Killer Cell Lectin-Like Receptor Subfamily G, Member 2) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is KLRG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRG2 Gene

Genomics for KLRG2 Gene

Regulatory Elements for KLRG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLRG2 Gene

Start:
139,452,414 bp from pter
End:
139,483,712 bp from pter
Size:
31,299 bases
Orientation:
Minus strand

Genomic View for KLRG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRG2 Gene

Proteins for KLRG2 Gene

  • Protein details for KLRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1S0-KLRG2_HUMAN
    Recommended name:
    Killer cell lectin-like receptor subfamily G member 2
    Protein Accession:
    A4D1S0
    Secondary Accessions:
    • Q2NL79
    • Q6ZTV6

    Protein attributes for KLRG2 Gene

    Size:
    409 amino acids
    Molecular mass:
    42851 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLRG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLRG2 Gene

Proteomics data for KLRG2 Gene at MOPED

Post-translational modifications for KLRG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLRG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRG2 Gene

Domains for KLRG2 Gene

Gene Families for KLRG2 Gene

HGNC:
  • CLEC :C-type lectin domain containing
  • KLR :Killer cell lectin-like receptors

Protein Domains for KLRG2 Gene

Suggested Antigen Peptide Sequences for KLRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1S0

UniProtKB/Swiss-Prot:

KLRG2_HUMAN :
  • A4D1S0
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRG2: view

Function for KLRG2 Gene

Gene Ontology (GO) - Molecular Function for KLRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRG2: view

Phenotypes for KLRG2 Gene

GenomeRNAi human phenotypes for KLRG2:
genes like me logo Genes that share phenotypes with KLRG2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLRG2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLRG2 Gene

Localization for KLRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRG2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLRG2 Gene COMPARTMENTS Subcellular localization image for KLRG2 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRG2: view

Pathways for KLRG2 Gene

SuperPathways for KLRG2 Gene

No Data Available

Interacting Proteins for KLRG2 Gene

Gene Ontology (GO) - Biological Process for KLRG2 Gene

None

No data available for Pathways by source for KLRG2 Gene

Transcripts for KLRG2 Gene

mRNA/cDNA for KLRG2 Gene

(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLRG2 Gene

Killer cell lectin-like receptor subfamily G, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLRG2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLRG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRG2 Gene

No ASD Table

Relevant External Links for KLRG2 Gene

GeneLoc Exon Structure for
KLRG2
ECgene alternative splicing isoforms for
KLRG2

Expression for KLRG2 Gene

mRNA expression in normal human tissues for KLRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRG2 Gene

This gene is overexpressed in Nerve - Tibial (8.6), Esophagus - Mucosa (8.6), Thyroid (7.1), Minor Salivary Gland (5.4), Skin - Sun Exposed (Lower leg) (5.2), and Skin - Not Sun Exposed (Suprapubic) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KLRG2 Gene

SOURCE GeneReport for Unigene cluster for KLRG2 Gene Hs.17572

genes like me logo Genes that share expressions with KLRG2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLRG2 Gene

Orthologs for KLRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRG2 35
  • 99.35 (n)
  • 99.27 (a)
KLRG2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLRG2 35
  • 78.21 (n)
  • 66.41 (a)
KLRG2 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
KLRG2 35
  • 82.46 (n)
  • 76.97 (a)
mouse
(Mus musculus)
Mammalia Klrg2 35
  • 72.39 (n)
  • 63.81 (a)
Klrg2 16
Klrg2 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLRG2 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klrg2 35
  • 72.65 (n)
  • 64.08 (a)
chicken
(Gallus gallus)
Aves KLRG2 36
  • 23 (a)
OneToOne
Species with no ortholog for KLRG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRG2 Gene

ENSEMBL:
Gene Tree for KLRG2 (if available)
TreeFam:
Gene Tree for KLRG2 (if available)

Paralogs for KLRG2 Gene

Paralogs for KLRG2 Gene

genes like me logo Genes that share paralogs with KLRG2: view

Variants for KLRG2 Gene

Sequence variations from dbSNP and Humsavar for KLRG2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs887056 -- 139,476,386(-) gtctg(C/G)acctg intron-variant
rs1006482 -- 139,483,870(-) GCTGC(C/T)GTTCT upstream-variant-2KB
rs1138692 -- 139,461,712(+) TTCCT(A/C/T)TACCT intron-variant
rs1138883 -- 139,461,735(+) taaaa(C/T)ggccc intron-variant
rs1139259 -- 139,463,276(+) ataca(C/T)tttat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRG2 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv526825 CNV Loss 19592680
nsv526644 CNV Loss 19592680

Relevant External Links for KLRG2 Gene

HapMap Linkage Disequilibrium report
KLRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRG2 Gene

Disorders for KLRG2 Gene

Relevant External Links for KLRG2

Genetic Association Database (GAD)
KLRG2
Human Genome Epidemiology (HuGE) Navigator
KLRG2
genes like me logo Genes that share disorders with KLRG2: view

No data available for UniProtKB/Swiss-Prot for KLRG2 Gene

Publications for KLRG2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. (PMID: 20945404) Liu X. … Witte J.S. (Prostate 2011) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4

Products for KLRG2 Gene

Sources for KLRG2 Gene

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