KLRG2 Gene
protein-coding GIFtS: 41
GCID: GC07M139137
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killer cell lectin-like receptor subfamily G, member 2
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Aliases
for KLRG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Killer Cell Lectin-Like Receptor Subfamily G, Member 21 2 | | CLEC15B1 2 3 | | C-Type Lectin Domain Family 15 Member B2 3 | | FLJ441861 | | C-Type Lectin Domain Family 15, Member B2 | | Killer Cell Lectin-Like Receptor Subfamily G Member 22 |
Export aliases for KLRG2 gene to outside databasesPrevious GC identifers: GC07M138787 GC07M133447 |
Summaries
for KLRG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLRG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLRG2 gene promoter:
AhR Pbx1a XBP-1 CUTL1 Nkx5-1 Arnt FOXO1a Pax-4a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLRG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34KLRG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M139137: view genomic region
(about GC identifiers)
Start:
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139,137,436 bp from pter |
End:
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139,168,458 bp from pter |
Size:
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31,023 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 138,482,632-138,513,003 |
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Proteins
for KLRG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLRG2_HUMAN, A4D1S0 (See
protein sequence)Recommended Name: Killer cell lectin-like receptor subfamily G member 2 Size: 409 amino acids; 42851 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q2NL79 Q6ZTV6Alternative splicing: 2 isoforms: A4D1S0-1 A4D1S0-2 Explore the universe of human proteins at neXtProt for KLRG2: NX_A4D1S0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A4D1S0
KLRG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940910.1
ENSEMBL proteins: ENSP00000339356 ENSP00000376759
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
KLRG2 for ontologies About GeneDecksing
KLRG2 Antibody Products:
Assay Products for KLRG2: |
Protein
Domains /
Families
for KLRG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLRG2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A4D1S0ProtoNet protein and cluster: A4D1S0 UniProtKB/Swiss-Prot: KLRG2_HUMAN, A4D1S0Similarity: Contains 1 C-type lectin domain |
Function
for KLRG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLRG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLRG2 (NM_198508) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLRG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRG2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRG2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
IEA | -- |
KLRG2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KLRG2:
|
Pathways & Interactions
for KLRG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLRG2
|
Drugs & Compounds
for KLRG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLRG2
Search CenterWatch for drugs/clinical trials and news about KLRG2
|
Transcripts
for KLRG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLRG2 gene: NM_198508.2 Unigene Cluster for KLRG2: Killer cell lectin-like receptor subfamily G, member 2 Hs.17572 [show with all ESTs]Unigene Representative Sequence: BC1108582 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340940(uc003vvb.3 uc010lnc.3) ENST00000393039
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLRG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLRG2 (NM_198508) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLRG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRG2 |
Additional cDNA sequence: BC104963.1 BC104965.1 BC110858.1 3 DOTS entries: DT.40293825 DT.305721 DT.100671078 10 AceView cDNA sequences: BM557832 NM_198508 AI583696 BE219512 AW197495 AA742567 AK126174 BM853440 BU181520 CD517457
GeneLoc Exon Structure
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Expression
for KLRG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLRG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCACATTT
About this image
See KLRG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLRG2
SOURCE GeneReport for Unigene cluster: Hs.17572
SABiosciences Custom PCR Arrays for KLRG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLRG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLRG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRG2 |
Orthologs
for KLRG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for KLRG2 (if available)
TreeFam Gene Tree for KLRG2 (if available) |
Paralogs
for KLRG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLRG2 gene
- CLEC2A2 CLEC2L2 CLEC2B2 KLRF22 CD692 CLEC2D2 CLEC5A2 KLRF12
- KLRG12 KLRB12
1 SIMAP similar gene for KLRG2 using alignment to 1 protein entry: KLRG2_HUMAN:CLEC2B
KLRG2 for paralogs About GeneDecksing
|
Genomic Variants
for KLRG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLRG2 (139137436 - 139168458 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLRG2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRG2 |
|
Disorders
/ Diseases
for KLRG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLRG2 for disorders About GeneDecksing
2  diseases for KLRG2: About MalaCardsprostate cancer prostatitis
Human Genome Epidemiology (HuGE) Navigator: KLRG2 (1 document)
Export disorders for KLRG2 gene to outside databases
|
Publications
for KLRG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLRG2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLRG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fine-mapping of prostate cancer aggressiveness loci o n chromosome 7q22-35. (PubMed id 20945404)1 Liu X....Witte J.S. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KLRG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KLRG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLRG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLRG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLRG2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KLRG2 gene:
Search GeneIP for patents involving KLRG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLRG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLRG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLRG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLRG2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLRG2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLRG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLRG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRG2 |
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 | | | KLRG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRG2 |
|  |  |  | | | | Search ThermoFisher Antibodies for KLRG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRG2 |
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