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Aliases for KLRG1 Gene

Aliases for KLRG1 Gene

  • Killer Cell Lectin-Like Receptor Subfamily G, Member 1 2 3
  • MAFA 3 4 6
  • C-Type Lectin Domain Family 15 Member A 3 4
  • ITIM-Containing Receptor MAFA-L 3 4
  • MAFA-Like Receptor 3 4
  • CLEC15A 3 4
  • MAFAL 4 6
  • Mast Cell Function-Associated Antigen (ITIM-Containing) 3
  • Killer Cell Lectin-Like Receptor Subfamily G Member 1 3
  • C-Type Lectin Domain Family 15, Member A 3
  • Mast Cell Function-Associated Antigen 4
  • C-Type Lectin Domain Family 15 2
  • MAFA-LIKE 3
  • Member A 2
  • MAFA-2F1 3
  • MAFA-L 3
  • 2F1 3

External Ids for KLRG1 Gene

Previous GeneCards Identifiers for KLRG1 Gene

  • GC12P008850
  • GC12P009290
  • GC12P009002
  • GC12P009033
  • GC12P009142

Summaries for KLRG1 Gene

Entrez Gene Summary for KLRG1 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRG1 Gene

KLRG1 (Killer Cell Lectin-Like Receptor Subfamily G, Member 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and L1CAM interactions. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is KLRG2.

UniProtKB/Swiss-Prot for KLRG1 Gene

  • Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.

Gene Wiki entry for KLRG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRG1 Gene

Genomics for KLRG1 Gene

Regulatory Elements for KLRG1 Gene

Genomic Location for KLRG1 Gene

Start:
8,950,044 bp from pter
End:
9,058,157 bp from pter
Size:
108,114 bases
Orientation:
Plus strand

Genomic View for KLRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRG1 Gene

Proteins for KLRG1 Gene

  • Protein details for KLRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E93-KLRG1_HUMAN
    Recommended name:
    Killer cell lectin-like receptor subfamily G member 1
    Protein Accession:
    Q96E93
    Secondary Accessions:
    • B7ZAM2
    • O43198
    • O75613

    Protein attributes for KLRG1 Gene

    Size:
    195 amino acids
    Molecular mass:
    21831 Da
    Quaternary structure:
    • Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D.

    Three dimensional structures from OCA and Proteopedia for KLRG1 Gene

    Alternative splice isoforms for KLRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLRG1 Gene

Proteomics data for KLRG1 Gene at MOPED

Post-translational modifications for KLRG1 Gene

  • Glycosylation at Asn65, Asn97, Asn137, and Asn150
  • Modification sites at PhosphoSitePlus

Other Protein References for KLRG1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRG1 Gene

Domains for KLRG1 Gene

Gene Families for KLRG1 Gene

HGNC:
  • CLEC :C-type lectin domain containing
  • KLR :Killer cell lectin-like receptors

Protein Domains for KLRG1 Gene

Suggested Antigen Peptide Sequences for KLRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96E93

UniProtKB/Swiss-Prot:

KLRG1_HUMAN :
  • Q96E93
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity).
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRG1: view

Function for KLRG1 Gene

Molecular function for KLRG1 Gene

GENATLAS Biochemistry: natural killer cell lectin-like receptor,subfamily G,member 1,in the NK (natural killer) complex (NKG2@),expressed in peripheral blood by NK cells,also expressed in most cells and basophils
UniProtKB/Swiss-Prot Function: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
UniProtKB/Swiss-Prot Induction: By pathogens and viruses infections.

Gene Ontology (GO) - Molecular Function for KLRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9765598
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRG1: view

Phenotypes for KLRG1 Gene

genes like me logo Genes that share phenotypes with KLRG1: view

miRNA for KLRG1 Gene

miRTarBase miRNAs that target KLRG1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLRG1 Gene

Localization for KLRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRG1 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLRG1 Gene COMPARTMENTS Subcellular localization image for KLRG1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRG1: view

Pathways for KLRG1 Gene

genes like me logo Genes that share pathways with KLRG1: view

Gene Ontology (GO) - Biological Process for KLRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9842918
GO:0006968 cellular defense response TAS 9842918
GO:0007166 cell surface receptor signaling pathway TAS 9842918
GO:0045087 innate immune response IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KLRG1: view

Transcripts for KLRG1 Gene

Unigene Clusters for KLRG1 Gene

Killer cell lectin-like receptor subfamily G, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRG1 Gene

No ASD Table

Relevant External Links for KLRG1 Gene

GeneLoc Exon Structure for
KLRG1
ECgene alternative splicing isoforms for
KLRG1

Expression for KLRG1 Gene

mRNA expression in normal human tissues for KLRG1 Gene

mRNA differential expression in normal tissues according to GTEx for KLRG1 Gene

This gene is overexpressed in Whole Blood (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLRG1 Gene

SOURCE GeneReport for Unigene cluster for KLRG1 Gene Hs.558446

mRNA Expression by UniProt/SwissProt for KLRG1 Gene

Q96E93-KLRG1_HUMAN
Tissue specificity: Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
genes like me logo Genes that share expressions with KLRG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KLRG1 Gene

Orthologs for KLRG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRG1 35
  • 99.12 (n)
  • 98.94 (a)
KLRG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLRG1 35
  • 77.66 (n)
  • 65.41 (a)
KLRG1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLRG1 35
  • 78.01 (n)
  • 66.49 (a)
KLRG1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klrg1 35
  • 71.68 (n)
  • 57.53 (a)
Klrg1 16
Klrg1 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klrg1 35
  • 68.64 (n)
  • 55.38 (a)
Species with no ortholog for KLRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRG1 Gene

ENSEMBL:
Gene Tree for KLRG1 (if available)
TreeFam:
Gene Tree for KLRG1 (if available)

Paralogs for KLRG1 Gene

Paralogs for KLRG1 Gene

Selected SIMAP similar genes for KLRG1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLRG1: view

Variants for KLRG1 Gene

Sequence variations from dbSNP and Humsavar for KLRG1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs759468 -- 9,037,615(-) GTGAG(C/T)GAATG intron-variant
rs759469 -- 9,023,108(-) tggct(C/T)taaat intron-variant
rs759470 -- 9,023,092(-) tatcc(C/T)tgaca intron-variant
rs764769 -- 9,038,774(-) TTACA(C/G)GTGCC intron-variant
rs881376 -- 9,050,157(-) CAATG(C/T)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRG1 Gene

Variant ID Type Subtype PubMed ID
nsv832327 CNV Loss 17160897
nsv521482 CNV Loss 19592680

Relevant External Links for KLRG1 Gene

HapMap Linkage Disequilibrium report
KLRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRG1 Gene

Disorders for KLRG1 Gene

(6) Novoseek inferred disease relationships for KLRG1 Gene

Disease -log(P) Hits PubMed IDs
leukemia mast cell 74.1 1
mastocytosis 58.7 2
mastocytosis systemic 54.7 1
influenza 12.7 4
virus infection 12.2 2

Relevant External Links for KLRG1

Genetic Association Database (GAD)
KLRG1
Human Genome Epidemiology (HuGE) Navigator
KLRG1
genes like me logo Genes that share disorders with KLRG1: view

No data available for UniProtKB/Swiss-Prot for KLRG1 Gene

Publications for KLRG1 Gene

  1. MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. (PMID: 9842918) Butcher S. … Cook G.P. (Eur. J. Immunol. 1998) 2 3 4 23
  2. 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. (PMID: 9862378) Hanke T. … Raulet D.H. (Eur. J. Immunol. 1998) 2 3 23
  3. Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans. (PMID: 17617594) Schwartzkopff S. … Pircher H. (J. Immunol. 2007) 3 4 23
  4. Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. (PMID: 16461340) Ito M. … Matsumoto N. (J. Exp. Med. 2006) 2 3 23
  5. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. (PMID: 15879103) Ibegbu C.C. … Kourtis A.P. (J. Immunol. 2005) 3 4 23

Products for KLRG1 Gene

Sources for KLRG1 Gene

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