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KLRG1 Gene

protein-coding   GIFtS: 58
GCID: GC12P009142

Killer Cell Lectin-Like Receptor Subfamily G, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Lectin-Like Receptor Subfamily G, Member 11 2     2F12
MAFA2 3 5     MAFA-2F12
CLEC15A2 3     MAFA-L2
C-Type Lectin Domain Family 15 Member A2 3     MAFA-LIKE2
ITIM-Containing Receptor MAFA-L2 3     C-Type Lectin Domain Family 15, Member A2
MAFA-Like Receptor2 3     Killer Cell Lectin-Like Receptor Subfamily G Member 12
MAFAL3 5     Mast Cell Function-Associated Antigen (ITIM-Containing)2
C-Type Lectin Domain Family 151     Mast Cell Function-Associated Antigen3
Member A1     

External Ids:    HGNC: 63801   Entrez Gene: 102192   Ensembl: ENSG000001391877   OMIM: 6048745   UniProtKB: Q96E933   

Export aliases for KLRG1 gene to outside databases

Previous GC identifers: GC12P008850 GC12P009290 GC12P009002 GC12P009033 GC12P008922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLRG1 Gene:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells
without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein
encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of
transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of
this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been
reported, but their full-length natures have not yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLRG1 Gene:
KLRG1 (killer cell lectin-like receptor subfamily G, member 1) is a protein-coding gene. Diseases associated with KLRG1 include listeriosis, and lymphocytic choriomeningitis. GO annotations related to this gene include carbohydrate binding and receptor activity. An important paralog of this gene is KLRG2.

UniProtKB/Swiss-Prot: KLRG1_HUMAN, Q96E93
Function: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC
ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins,
enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells

Gene Wiki entry for KLRG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLRG1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   RREB-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRG1 promoter sequence
   Search Chromatin IP Primers for KLRG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

KLRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRG1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P009142:  view genomic region     (about GC identifiers)

Start:
9,102,640 bp from pter      End:
9,163,356 bp from pter
Size:
60,717 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLRG1_HUMAN, Q96E93 (See protein sequence)
Recommended Name: Killer cell lectin-like receptor subfamily G member 1  
Size: 195 amino acids; 21831 Da
Subunit: Forms a monomer and homodimer; disulfide-linked (By similarity). Interacts (via ITIM motif) with PTPN11
and INPP5D (By similarity)
1 PDB 3D structure from and Proteopedia for KLRG1:
3FF7 (3D)    
Secondary accessions: B7ZAM2 O43198 O75613
Alternative splicing: 2 isoforms:  Q96E93-1   Q96E93-2   

Explore the universe of human proteins at neXtProt for KLRG1: NX_Q96E93

Explore proteomics data for KLRG1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn97, Asn137, Asn150

  • See KLRG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005801.3  
    ENSEMBL proteins: 
     ENSP00000445627   ENSP00000349477   ENSP00000266551   ENSP00000443658  
    Reactome Protein details: Q96E93

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLR: Killer cell lectin-like receptors
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q96E93

    ProtoNet protein and cluster: Q96E93

    UniProtKB/Swiss-Prot: KLRG1_HUMAN, Q96E93
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif
    KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity)
    Similarity: Contains 1 C-type lectin domain


    KLRG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLRG1_HUMAN, Q96E93
    Function: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC
    ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins,
    enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells
    Induction: By pathogens and viruses infections

         Genatlas biochemistry entry for KLRG1:
    natural killer cell lectin-like receptor,subfamily G,member 1,in the NK (natural killer) complex (NKG2@),expressed
    in peripheral blood by NK cells,also expressed in most cells and basophils

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9765598
    GO:0030246carbohydrate binding IEA--
         
    KLRG1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KLRG1:
     Decreased POU5F1-GFP protein e  Decreased cilium length after  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Klrg1):
     normal 

    KLRG1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLRG1
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    miRNA
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    miRTarBase miRNAs that target KLRG1:
    hsa-mir-877-3p (MIRT036992)

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    Selected qRT-PCR Assays for microRNAs that regulate KLRG1 (see all 11):
    hsa-miR-3607-3p hsa-miR-3200-5p hsa-miR-3611 hsa-miR-1258 hsa-miR-138-2* hsa-miR-1304 hsa-miR-188-3p hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidKLRG1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLRG1_HUMAN, Q96E93: Cell membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    KLRG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLRG1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for KLRG1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell



    KLRG1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLRG1
    Interactions:

        GeneGlobe Interaction Network for KLRG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for KLRG1 (Q96E932, 3 ENSP000003494774) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LEPROTL1O952142, 3, ENSP000004128034MINT-67902 I2D: score=4 STRING: ENSP00000412803
    CDH1ENSP000002617694STRING: ENSP00000261769
    FCER1GENSP000002899024STRING: ENSP00000289902
    INPP5DENSP000003525754STRING: ENSP00000352575
    PTPN11ENSP000003409444STRING: ENSP00000340944
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS9842918
    GO:0006968cellular defense response TAS9842918
    GO:0007166cell surface receptor signaling pathway TAS9842918
    GO:0045087innate immune response IEA--
    GO:0050776regulation of immune response TAS--

    KLRG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLRG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLRG1 gene: 
    NM_005810.3  

    Unigene Cluster for KLRG1:

    Killer cell lectin-like receptor subfamily G, member 1
    Hs.558446  [show with all ESTs]
    Unigene Representative Sequence: NM_005810
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539240 ENST00000544226 ENST00000538029 ENST00000541957 ENST00000356986
    ENST00000266551(uc001qvg.3 uc001qvh.3) ENST00000543895
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KLRG1 (see all 11):
    hsa-miR-3607-3p hsa-miR-3200-5p hsa-miR-3611 hsa-miR-1258 hsa-miR-138-2* hsa-miR-1304 hsa-miR-188-3p hsa-miR-518a-5p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF034952.1 AF081675.1 AF097358.1 AK301367.1 AK316337.1 BC012621.1 

    7 DOTS entries:

    DT.121125321  DT.100706717  DT.40118064  DT.97814491  DT.121125380  DT.40229521  DT.92419884 

    Selected AceView cDNA sequences (see all 30):

    AI803445 AA748900 AA283705 AA290716 AW976628 AI433079 BC012621 NM_005810 
    AF034952 BX098337 BG500830 BG207005 AA308877 BF241894 AI263172 AA188327 
    BX354588 CK001855 AA186699 BQ212545 AF097358 BI832809 AI383074 AF081675 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLRG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGTATCT
    KLRG1 Expression
    About this image

    KLRG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLRG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558446

    UniProtKB/Swiss-Prot: KLRG1_HUMAN, Q96E93
    Tissue specificity: Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLRG1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrg11 , 5 killer cell lectin-like receptor subfamily G, member more1, 5 71.68(n)1
    57.53(a)1
      6 (57.52 cM)5
    509281  NM_016970.11  NP_058666.11 
     1222705965 


    ENSEMBL Gene Tree for KLRG1 (if available)
    TreeFam Gene Tree for KLRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLRG1 gene
    KLRG22  
    13 SIMAP similar genes for KLRG1 using alignment to 3 protein entries:     KLRG1_HUMAN (see all proteins):
    ASGR1    CLEC2L    CLEC10A    OLR1    CLEC2D    KLRD1
    KLRF1    SELP    KLRC1    KLRC2    NCAN    CLEC2B
    CLEC4M

    KLRG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLRG1 (see all 412)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829716781,2
    --9140282(+) TTCAGA/TAACCA 1 -- us2k10--------
    rs783081521,2
    C--9140323(+) CTTTAG/TATTCC 1 -- us2k10--------
    rs1882433211,2
    --9140405(+) GGTTCA/GTCAGT 1 -- us2k10--------
    rs1433646111,2
    --9140502(+) AAGGGC/TGTGAA 1 -- us2k10--------
    rs1927810901,2
    --9140526(+) AGGCAA/GCTAAA 1 -- us2k10--------
    rs18057531,2
    C,F,H--9140867(-) ACCACT/GTTCTA 1 -- us2k19Minor allele frequency- G:0.02NS EA NA 1382
    rs1833122871,2
    --9140938(+) TGCTGC/TCTGTG 1 -- us2k10--------
    rs1874467151,2
    --9141183(+) TTTTGC/TTTTTT 1 -- us2k10--------
    rs1483411041,2
    --9141356(+) TATTTA/TTAGTA 1 -- us2k10--------
    rs1927650631,2
    --9141500(+) AACTTC/TTCACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLRG1 (9102640 - 9163356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLRG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521482CNV Loss19592680
    nsv832327CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604874    OMIM disorders: --

    12 diseases for KLRG1:    About MalaCards
    listeriosis    lymphocytic choriomeningitis    mastocytosis    cytomegalovirus infection
    influenza    myelodysplastic syndromes    hepatitis c virus    hepatitis c
    hepatitis    hepatitis b    leukemia    neuronitis


    KLRG1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for KLRG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia mast cell 74.1 1 8558922 (1)
    mastocytosis 58.7 2 8766423 (1), 8557056 (1)
    mastocytosis systemic 54.7 1 8558922 (1)
    influenza 12.7 5 15879103 (2), 16140789 (1), 17079288 (1)
    virus infection 12.2 2 16140789 (1), 17686974 (1)
    immunodeficiency 0 3 16140789 (1), 17079288 (1)

    Genetic Association Database (GAD): KLRG1
    Human Genome Epidemiology (HuGE) Navigator: KLRG1 (2 documents)

    Export disorders for KLRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLRG1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with KLRG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. (PubMed id 9842918)1, 2, 3, 9 Butcher S.... Cook G.P. (Eur. J. Immunol. 1998)
    2. 2F1 antigen, the mouse homolog of the rat &quot;mast cell function-associated antigen&quot;, is a lectin-like type II transmembrane receptor expressed by natural killer cells. (PubMed id 9862378)1, 3, 9 Hanke T....Raulet D.H. (Eur. J. Immunol. 1998)
    3. Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans. (PubMed id 17617594)1, 2, 9 Schwartzkopff S.... Pircher H. (J. Immunol. 2007)
    4. Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. (PubMed id 16461340)1, 3, 9 Ito M....Matsumoto N. (J. Exp. Med. 2006)
    5. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. (PubMed id 15879103)1, 2, 9 Ibegbu C.C.... Kourtis A.P. (J. Immunol. 2005)
    6. Human MAFA has alternatively spliced variants. (PubMed id 9765598)1, 2, 9 Lamers M.B.A.C.... Williams D.H. (Biochim. Biophys. Acta 1998)
    7. Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. (PubMed id 19604491)1, 2, 9 Li Y....Mariuzza R.A. (Immunity 2009)
    8. Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. (PubMed id 16140789)1, 3, 9 Thimme R....Pircher H. (J. Virol. 2005)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). (PubMed id 12393723)1, 9 Voehringer D....Pircher H. (Blood 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10219 HGNC: 6380 AceView: KLRG1 Ensembl:ENSG00000139187 euGenes: HUgn10219
    ECgene: KLRG1 H-InvDB: KLRG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLRG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLRG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLRG1 gene:
    Search GeneIP for patents involving KLRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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