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Aliases for KLRF2 Gene

Aliases for KLRF2 Gene

  • Killer Cell Lectin Like Receptor F2 2 3
  • Killer Cell Lectin-Like Receptor Subfamily F, Member 2 2 3 5
  • Activating Coreceptor NKp65 3 4
  • Lectin-Like Receptor F2 3 4
  • NKp65 3

External Ids for KLRF2 Gene

Previous GeneCards Identifiers for KLRF2 Gene

  • GC12U901452
  • GC12P009776
  • GC12P010034

Summaries for KLRF2 Gene

GeneCards Summary for KLRF2 Gene

KLRF2 (Killer Cell Lectin Like Receptor F2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is KLRF1.

UniProtKB/Swiss-Prot for KLRF2 Gene

  • C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRF2 Gene

Genomics for KLRF2 Gene

Regulatory Elements for KLRF2 Gene

Enhancers for KLRF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLRF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLRF2 Gene

9,881,489 bp from pter
9,895,833 bp from pter
14,345 bases
Plus strand

Genomic View for KLRF2 Gene

Genes around KLRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRF2 Gene

Proteins for KLRF2 Gene

  • Protein details for KLRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell lectin-like receptor subfamily F member 2
    Protein Accession:

    Protein attributes for KLRF2 Gene

    207 amino acids
    Molecular mass:
    24008 Da
    Quaternary structure:
    • Homodimer; non disulfide-linked. Interacts with CLEC2A.

    Three dimensional structures from OCA and Proteopedia for KLRF2 Gene

neXtProt entry for KLRF2 Gene

Proteomics data for KLRF2 Gene at MOPED

Post-translational modifications for KLRF2 Gene

Other Protein References for KLRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRF2 Gene

Domains & Families for KLRF2 Gene

Gene Families for KLRF2 Gene

Protein Domains for KLRF2 Gene

Suggested Antigen Peptide Sequences for KLRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRF2: view

Function for KLRF2 Gene

Molecular function for KLRF2 Gene

UniProtKB/Swiss-Prot Function:
C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLRF2 Gene

Localization for KLRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRF2 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for KLRF2 Gene COMPARTMENTS Subcellular localization image for KLRF2 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for KLRF2 Gene

Pathways & Interactions for KLRF2 Gene

SuperPathways for KLRF2 Gene

No Data Available

Interacting Proteins for KLRF2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000438244 for KLRF2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KLRF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLRF2 Gene

Drugs & Compounds for KLRF2 Gene

No Compound Related Data Available

Transcripts for KLRF2 Gene

mRNA/cDNA for KLRF2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KLRF2 Gene

No ASD Table

Relevant External Links for KLRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRF2 Gene

mRNA expression in normal human tissues for KLRF2 Gene

mRNA differential expression in normal tissues according to GTEx for KLRF2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x24.2) and Skin - Not Sun Exposed (Suprapubic) (x18.6).

SOURCE GeneReport for Unigene cluster for KLRF2 Gene Hs.725113

genes like me logo Genes that share expression patterns with KLRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLRF2 Gene

Orthologs for KLRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLRF2 35
  • 79.46 (n)
  • 64.65 (a)
KLRF2 36
  • 64 (a)
(Canis familiaris)
Mammalia KLRF2 35
  • 78.72 (n)
  • 63.84 (a)
(Pan troglodytes)
Mammalia KLRF2 35
  • 97.75 (n)
  • 96.62 (a)
KLRF2 36
  • 97 (a)
(Gallus gallus)
Aves BLEC2 36
  • 19 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
-- 36
  • 25 (a)
-- 36
  • 9 (a)
Species with no ortholog for KLRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRF2 Gene

Gene Tree for KLRF2 (if available)
Gene Tree for KLRF2 (if available)

Paralogs for KLRF2 Gene

Paralogs for KLRF2 Gene

(2) SIMAP similar genes for KLRF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLRF2: view

Variants for KLRF2 Gene

Sequence variations from dbSNP and Humsavar for KLRF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2034339 -- 9,879,581(+) TCTCC(C/T)GATCT upstream-variant-2KB
rs10844999 -- 9,880,157(+) AAGTT(C/T)GGACA upstream-variant-2KB
rs7315486 -- 9,880,331(+) ATGGA(C/T)GCGGC upstream-variant-2KB
rs935537 -- 9,879,671(+) CAATA(C/G)ATTCA upstream-variant-2KB
rs112415658 -- 9,880,229(+) CTTAT(C/G)AGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLRF2 Gene

Variant ID Type Subtype PubMed ID
nsv523050 CNV Loss 19592680

Variation tolerance for KLRF2 Gene

Gene Damage Index Score: 1.91; 35.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLRF2 Gene

Disorders for KLRF2 Gene

Relevant External Links for KLRF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRF2 Gene

Publications for KLRF2 Gene

  1. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. (PMID: 20194751) Spreu J. … Steinle A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 2 3 4 67
  2. Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65. (PMID: 25510854) Bauer B. … Steinle A. (Immunology 2015) 3
  3. Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. (PMID: 23803857) Li Y. … Mariuzza R.A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for KLRF2 Gene

Sources for KLRF2 Gene