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Aliases for KLRF2 Gene

Aliases for KLRF2 Gene

  • Killer Cell Lectin-Like Receptor Subfamily F, Member 2 2 3
  • Activating Coreceptor NKp65 3 4
  • Lectin-Like Receptor F2 3 4
  • Killer Cell Lectin-Like Receptor Subfamily F Member 2 3
  • NKp65 3

External Ids for KLRF2 Gene

Previous GeneCards Identifiers for KLRF2 Gene

  • GC12U901452
  • GC12P009776
  • GC12P010034

Summaries for KLRF2 Gene

GeneCards Summary for KLRF2 Gene

KLRF2 (Killer Cell Lectin-Like Receptor Subfamily F, Member 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is CLECL1.

UniProtKB/Swiss-Prot for KLRF2 Gene

  • C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRF2 Gene

Genomics for KLRF2 Gene

Genomic Location for KLRF2 Gene

Start:
9,881,489 bp from pter
End:
9,895,833 bp from pter
Size:
14,345 bases
Orientation:
Plus strand

Genomic View for KLRF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRF2 Gene

No data available for Regulatory Elements for KLRF2 Gene

Proteins for KLRF2 Gene

  • Protein details for KLRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    D3W0D1-KLRF2_HUMAN
    Recommended name:
    Killer cell lectin-like receptor subfamily F member 2
    Protein Accession:
    D3W0D1
    Secondary Accessions:

    Protein attributes for KLRF2 Gene

    Size:
    207 amino acids
    Molecular mass:
    24008 Da
    Quaternary structure:
    • Homodimer; non disulfide-linked. Interacts with CLEC2A.

    Three dimensional structures from OCA and Proteopedia for KLRF2 Gene

neXtProt entry for KLRF2 Gene

Proteomics data for KLRF2 Gene at MOPED

Post-translational modifications for KLRF2 Gene

Other Protein References for KLRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRF2 Gene

Domains for KLRF2 Gene

Gene Families for KLRF2 Gene

HGNC:
  • CLEC :C-type lectin domain containing
  • KLR :Killer cell lectin-like receptors

Protein Domains for KLRF2 Gene

Suggested Antigen Peptide Sequences for KLRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

D3W0D1

UniProtKB/Swiss-Prot:

KLRF2_HUMAN :
  • D3W0D1
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRF2: view

Function for KLRF2 Gene

Molecular function for KLRF2 Gene

UniProtKB/Swiss-Prot Function: C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

Gene Ontology (GO) - Molecular Function for KLRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20194751
GO:0030246 carbohydrate binding IEA --
GO:0042803 protein homodimerization activity IDA 20194751
genes like me logo Genes that share ontologies with KLRF2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLRF2 Gene

Localization for KLRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRF2 Gene

Cell membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for KLRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 20194751
genes like me logo Genes that share ontologies with KLRF2: view

No data available for Subcellular locations from COMPARTMENTS for KLRF2 Gene

Pathways for KLRF2 Gene

SuperPathways for KLRF2 Gene

No Data Available

Interacting Proteins for KLRF2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000438244%0d%0a9606.ENSP00000396163%0d%0a
Selected Interacting proteins: ENSP00000438244 for KLRF2 Gene via STRING

Symbol External ID(s) Details
CLEC2A

Gene Ontology (GO) - Biological Process for KLRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043320 natural killer cell degranulation TAS 20194751
GO:0050663 cytokine secretion TAS 20194751
genes like me logo Genes that share ontologies with KLRF2: view

No data available for Pathways by source for KLRF2 Gene

Transcripts for KLRF2 Gene

mRNA/cDNA for KLRF2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLRF2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRF2 Gene

No ASD Table

Relevant External Links for KLRF2 Gene

GeneLoc Exon Structure for
KLRF2
ECgene alternative splicing isoforms for
KLRF2

Expression for KLRF2 Gene

mRNA expression in normal human tissues for KLRF2 Gene

mRNA differential expression in normal tissues according to GTEx for KLRF2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (24.2) and Skin - Not Sun Exposed (Suprapubic) (18.6).

SOURCE GeneReport for Unigene cluster for KLRF2 Gene Hs.725113

genes like me logo Genes that share expressions with KLRF2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KLRF2 Gene

Orthologs for KLRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRF2 35
  • 97.75 (n)
  • 96.62 (a)
KLRF2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLRF2 35
  • 79.46 (n)
  • 64.65 (a)
KLRF2 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLRF2 35
  • 78.72 (n)
  • 63.84 (a)
chicken
(Gallus gallus)
Aves BLEC2 36
  • 19 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
Species with no ortholog for KLRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRF2 Gene

ENSEMBL:
Gene Tree for KLRF2 (if available)
TreeFam:
Gene Tree for KLRF2 (if available)

Paralogs for KLRF2 Gene

Paralogs for KLRF2 Gene

Selected SIMAP similar genes for KLRF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLRF2: view

Variants for KLRF2 Gene

Sequence variations from dbSNP and Humsavar for KLRF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs500221 -- 9,890,750(+) TCTAA(C/T)ATAAC intron-variant
rs559437 -- 9,884,805(+) TTTTA(A/G)ATTTT intron-variant
rs571135 -- 9,894,046(-) AGAAA(C/G)AAAGA intron-variant
rs576601 -- 9,893,453(+) TAAAA(A/C)CTGGA missense, reference
rs577575 -- 9,893,320(-) ATATA(C/T)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRF2 Gene

Variant ID Type Subtype PubMed ID
nsv523050 CNV Loss 19592680

Relevant External Links for KLRF2 Gene

HapMap Linkage Disequilibrium report
KLRF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRF2 Gene

Disorders for KLRF2 Gene

No disorders were found for KLRF2 Gene.

No data available for UniProtKB/Swiss-Prot for KLRF2 Gene

Publications for KLRF2 Gene

  1. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. (PMID: 20194751) Spreu J. … Steinle A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 2 3 4
  2. Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. (PMID: 23803857) Li Y. … Mariuzza R.A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for KLRF2 Gene

Sources for KLRF2 Gene

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