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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLRF1 Gene

protein-coding GIFtS: 46
GCID: GC12P009880

killer cell lectin-like receptor subfamily F, member 1

Explore 2 diseases affiliated with
KLRF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Killer Cell Lectin-Like Receptor Subfamily F, Member 1¹ ²		C-Type Lectin Domain Family 5 Member C² ³
CLEC5C¹ ² ³		Killer Cell Lectin-Like Receptor F1²
NKp80¹ ²		Killer Cell Lectin-Like Receptor Subfamily F Member 1²
Activating Coreceptor NKp80² ³		ML³
Lectin-Like Receptor F1² ³

External Ids:	HGNC: 13342¹	Entrez Gene: 51348²	Ensembl: ENSG00000150045⁷	OMIM: 605029⁵	UniProtKB: Q9NZS2³

Export aliases for KLRF1 gene to outside databases

Previous GC identifers: GC12P009662 GC12P010102 GC12P009871

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLRF1:

KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK)

cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 (PubMed 18922855)).(supplied by

OMIM, Oct 2009)

UniProtKB/Swiss-Prot: KLRF1_HUMAN, Q9NZS2

Function: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLRF1 gene promoter:
IRF-2 IRF-1 RORalpha2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLRF1 promoter sequence

Search SABiosciences Chromatin IP Primers for KLRF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

KLRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRF1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P009880: view genomic region (about GC identifiers)

Start:	9,980,077 bp from pter	End:	9,997,606 bp from pter
Size:	17,530 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: KLRF1_HUMAN, Q9NZS2 (See protein sequence)

Recommended Name: Killer cell lectin-like receptor subfamily F member 1

Size: 232 amino acids; 26666 Da

Subunit: Homodimer

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Secondary accessions: Q4KMT5 Q96PR2 Q96PR3 Q9NZS1

Alternative splicing: 4 isoforms: Q9NZS2-1 Q9NZS2-2 Q9NZS2-3 Q9NZS2-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for KLRF1: NX_Q9NZS2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NZS2

KLRF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057607.1

ENSEMBL proteins:

ENSP00000346919 ENSP00000322487 ENSP00000279544 ENSP00000279545 ENSP00000445022

ENSP00000443054 ENSP00000442884

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	10671213
GO:0016020	membrane	TAS	10671213

KLRF1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLRF1 for domains About GeneDecksing

3 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q9NZS2

ProtoNet protein and cluster: Q9NZS2

UniProtKB/Swiss-Prot: KLRF1_HUMAN, Q9NZS2

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KLRF1_HUMAN, Q9NZS2

Function: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	10671213
GO:0030246	carbohydrate binding	IEA	--
GO:0032393	MHC class I receptor activity	TAS	10671213

KLRF1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KLRF1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor signaling pathway	TAS	10671213

KLRF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLRF1
Search CenterWatch for drugs/clinical trials and news about KLRF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KLRF1 gene:

NM_016523.1

Unigene Cluster for KLRF1:

Killer cell lectin-like receptor subfamily F, member 1

Hs.183125 [show with all ESTs]

Unigene Representative Sequence: AJ305370

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354855(uc009zha.3) ENST00000324214(uc009zgw.3) ENST00000279544(uc021qux.1 uc009zgx.3 uc001qwm.3 uc009zgz.3)

ENST00000279545(uc009zgy.3) ENST00000545196 ENST00000537723 ENST00000535631

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Additional cDNA sequence:

AF175206.1 AF175207.1 AF267244.1 AF267245.1 AJ305370.1 BC096734.1 BC098166.1 BC098257.1

BC098354.1

4 DOTS entries:

DT.435636 DT.92417532 DT.95263208 DT.92417533

12 AceView cDNA sequences:

AF267245 AF267244 AA173389 AA424848 BG220404 AA426628 AF175206 AJ305370

AF175207 BX098311 NM_016523 T60164

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLRF1 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:											-
SP2:							-				-
SP3:									-
SP4:									-		-
SP5:							-		-		-

ECgene alternative splicing isoforms for KLRF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLRF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATCATATC

About this image
See KLRF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLRF1

SOURCE GeneReport for Unigene cluster: Hs.183125

UniProtKB/Swiss-Prot: KLRF1_HUMAN, Q9NZS2

Tissue specificity: Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node

and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart,

placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines,

expression was predominant in NK cells but was also detected in monocytes

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KLRF1 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	38(a) 32(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343438.1(108648-113029) 2(193068459-193075675)

ENSEMBL Gene Tree for KLRF1 (if available)
TreeFam Gene Tree for KLRF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLRF1 gene

CLEC2A² CLEC2L² CLEC2B² KLRF2² KLRG2² CD69² CLEC2D² CLEC5A²

KLRG1² KLRB1²

9 SIMAP similar genes for KLRF1 using alignment to 5 protein entries: KLRF1_HUMAN (see all proteins):

CLEC10A KLRC1 KLRD1 KLRC2 ASGR1 NCAN

KLRG1 CLEC2B KLRF2

KLRF1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200230617^1,2	--	--	9985283(+)	`TGTGTA/GTATGT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KLRF1 (9980077 - 9997606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLRF1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLRF1 for disorders           About GeneDecksing

OMIM gene information: 605029    OMIM disorders: --

2 diseases for KLRF1:    About MalaCards

hepatitis b hepatitis

Human Genome Epidemiology (HuGE) Navigator: KLRF1 (1 document)

Export disorders for KLRF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KLRF1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLRF1)

Utopia: connect your pdf to the dynamic
world of online information

Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis. (PubMed id 10671213)^{1, 2, 3, 9} Roda-Navarro P....Fernandez-Ruiz E. (2000)
Molecular characterization of two novel alternative spliced variants of the KLRF1 gene and subcellular distribution of KLRF1 isoforms. (PubMed id 11513955)^{1, 2, 9} Roda-Navarro P.... Fernandez-Ruiz E. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of NKp80, a novel triggering molecule expressed by human natural killer cells. (PubMed id 11265639)^{1, 2} Vitale M.... Moretta A. (2001)
Cutting edge: NKp80 uses an atypical hemi-ITAM to tri gger NK cytotoxicity. (PubMed id 21149606)¹ Dennehy K.M....Steinle A. (2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
NKp80 defines and stimulates a reactive subset of CD8 T cells. (PubMed id 18922855)¹ Kuttruff S....Steinle A. (2009)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51348	HGNC: 13342	AceView: KLRF1	Ensembl:ENSG00000150045	euGenes: HUgn51348
ECgene: KLRF1	H-InvDB: KLRF1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KLRF1	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_241

Intellectual Property for KLRF1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KLRF1 gene:
Search GeneIP for patents involving KLRF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRF1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KLRF1 gene at Home site.

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KLRF1 Gene

killer cell lectin-like receptor subfamily F, member 1

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KLRF1 Gene

killer cell lectin-like receptor subfamily F, member 1

Aliasesfor KLRF1 gene

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