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Aliases for KLRF1 Gene

Aliases for KLRF1 Gene

  • Killer Cell Lectin-Like Receptor Subfamily F, Member 1 2 3
  • C-Type Lectin Domain Family 5 Member C 3 4
  • Activating Coreceptor NKp80 3 4
  • Lectin-Like Receptor F1 3 4
  • CLEC5C 3 4
  • Killer Cell Lectin-Like Receptor Subfamily F Member 1 3
  • Killer Cell Lectin-Like Receptor F1 3
  • NKp80 3
  • ML 4

External Ids for KLRF1 Gene

Summaries for KLRF1 Gene

Entrez Gene Summary for KLRF1 Gene

  • KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

GeneCards Summary for KLRF1 Gene

KLRF1 (Killer Cell Lectin-Like Receptor Subfamily F, Member 1) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and MHC class I receptor activity. An important paralog of this gene is KLRF2.

UniProtKB/Swiss-Prot for KLRF1 Gene

  • Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRF1 Gene

Genomics for KLRF1 Gene

Genomic Location for KLRF1 Gene

Start:
9,827,481 bp from pter
End:
9,845,007 bp from pter
Size:
17,527 bases
Orientation:
Plus strand

Genomic View for KLRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRF1 Gene

Regulatory Elements for KLRF1 Gene

Proteins for KLRF1 Gene

  • Protein details for KLRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZS2-KLRF1_HUMAN
    Recommended name:
    Killer cell lectin-like receptor subfamily F member 1
    Protein Accession:
    Q9NZS2
    Secondary Accessions:
    • Q4KMT5
    • Q96PR2
    • Q96PR3
    • Q9NZS1

    Protein attributes for KLRF1 Gene

    Size:
    232 amino acids
    Molecular mass:
    26666 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for KLRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLRF1 Gene

Proteomics data for KLRF1 Gene at MOPED

Post-translational modifications for KLRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn77, Asn91, Asn96, and Asn177

No data available for DME Specific Peptides for KLRF1 Gene

Domains for KLRF1 Gene

Gene Families for KLRF1 Gene

HGNC:
  • CLEC :C-type lectin domain containing
  • KLR :Killer cell lectin-like receptors

Protein Domains for KLRF1 Gene

UniProtKB/Swiss-Prot:

KLRF1_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • Q9NZS2
genes like me logo Genes that share domains with KLRF1: view

Function for KLRF1 Gene

Molecular function for KLRF1 Gene

UniProtKB/Swiss-Prot Function: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts

Gene Ontology (GO) - Molecular Function for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671213
GO:0030246 carbohydrate binding IEA --
GO:0032393 MHC class I receptor activity TAS 10671213
genes like me logo Genes that share ontologies with KLRF1: view

miRNA for KLRF1 Gene

miRTarBase miRNAs that target KLRF1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLRF1 Gene

Localization for KLRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRF1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLRF1 Gene COMPARTMENTS Subcellular localization image for KLRF1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10671213
GO:0016020 membrane TAS 10671213
genes like me logo Genes that share ontologies with KLRF1: view

Pathways for KLRF1 Gene

SuperPathways for KLRF1 Gene

No Data Available

Interacting Proteins for KLRF1 Gene

Gene Ontology (GO) - Biological Process for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 10671213
genes like me logo Genes that share ontologies with KLRF1: view

No data available for Pathways by source for KLRF1 Gene

Transcripts for KLRF1 Gene

mRNA/cDNA for KLRF1 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLRF1 Gene

Killer cell lectin-like receptor subfamily F, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7:
SP8: - - - -

Relevant External Links for KLRF1 Gene

GeneLoc Exon Structure for
KLRF1
ECgene alternative splicing isoforms for
KLRF1

Expression for KLRF1 Gene

mRNA expression in normal human tissues for KLRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRF1 Gene

This gene is overexpressed in Whole Blood (23.0) and Spleen (9.4).

SOURCE GeneReport for Unigene cluster for KLRF1 Gene Hs.183125

mRNA Expression by UniProt/SwissProt for KLRF1 Gene

Q9NZS2-KLRF1_HUMAN
Tissue specificity: Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.
genes like me logo Genes that share expressions with KLRF1: view

Orthologs for KLRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRF1 36
  • 99.13 (n)
  • 98.27 (a)
KLRF1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLRF1 37
  • 72 (a)
OneToOne
LOC613393 36
  • 80.38 (n)
  • 72.73 (a)
dog
(Canis familiaris)
Mammalia KLRF1 36
  • 85.22 (n)
  • 78.7 (a)
KLRF1 37
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves BLEC2 37
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 28 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 13 (a)
ManyToMany
Species with no ortholog for KLRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRF1 Gene

ENSEMBL:
Gene Tree for KLRF1 (if available)
TreeFam:
Gene Tree for KLRF1 (if available)

Paralogs for KLRF1 Gene

Paralogs for KLRF1 Gene

Selected SIMAP similar genes for KLRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KLRF1: view

Variants for KLRF1 Gene

Sequence variations from dbSNP and Humsavar for KLRF1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs253145 -- 9,838,669(-) GTAAA(A/G)AATAG intron-variant
rs2012290 -- 9,845,190(+) TGAGC(A/T)GTGGT intron-variant
rs2232540 -- 9,826,918(+) ctatg(C/T)agtac upstream-variant-2KB
rs2232541 -- 9,827,222(+) AAAAA(A/G)GGGCA upstream-variant-2KB
rs2232542 -- 9,827,225(+) AAGGG(A/G)CATAA upstream-variant-2KB

Relevant External Links for KLRF1 Gene

HapMap Linkage Disequilibrium report
KLRF1

No data available for Structural Variations from Database of Genomic Variants (DGV) for KLRF1 Gene

Disorders for KLRF1 Gene

Relevant External Links for KLRF1

Human Genome Epidemiology (HuGE) Navigator
KLRF1
genes like me logo Genes that share disorders with KLRF1: view

No data available for UniProtKB/Swiss-Prot for KLRF1 Gene

Publications for KLRF1 Gene

  1. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis. (PMID: 10671213) Roda-Navarro P. … Fernandez-Ruiz E. (Eur. J. Immunol. 2000) 2 3 4 23
  2. Molecular characterization of two novel alternative spliced variants of the KLRF1 gene and subcellular distribution of KLRF1 isoforms. (PMID: 11513955) Roda-Navarro P. … Fernandez-Ruiz E. (Biochim. Biophys. Acta 2001) 3 4 23
  3. Identification of NKp80, a novel triggering molecule expressed by human natural killer cells. (PMID: 11265639) Vitale M. … Moretta A. (Eur. J. Immunol. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. NKp80 defines and stimulates a reactive subset of CD8 T cells. (PMID: 18922855) Kuttruff S. … Steinle A. (Blood 2009) 3

Products for KLRF1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KLRF1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KLRF1
    • Block miRNA regulation of KLRF1 using miScript Target Protectors

    Sources for KLRF1 Gene

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