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Aliases for KLRF1 Gene

Aliases for KLRF1 Gene

  • Killer Cell Lectin Like Receptor F1 2 3
  • Killer Cell Lectin-Like Receptor Subfamily F, Member 1 2 3 5
  • C-Type Lectin Domain Family 5 Member C 3 4
  • Activating Coreceptor NKp80 3 4
  • Lectin-Like Receptor F1 3 4
  • CLEC5C 3 4
  • Killer Cell Lectin-Like Receptor F1 3
  • NKp80 3
  • ML 4

External Ids for KLRF1 Gene

Previous GeneCards Identifiers for KLRF1 Gene

  • GC12P009662
  • GC12P010102
  • GC12P009880
  • GC12P009871
  • GC12P009980

Summaries for KLRF1 Gene

Entrez Gene Summary for KLRF1 Gene

  • KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

GeneCards Summary for KLRF1 Gene

KLRF1 (Killer Cell Lectin Like Receptor F1) is a Protein Coding gene. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity and MHC class I receptor activity. An important paralog of this gene is KLRF2.

UniProtKB/Swiss-Prot for KLRF1 Gene

  • Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRF1 Gene

Genomics for KLRF1 Gene

Regulatory Elements for KLRF1 Gene

Enhancers for KLRF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLRF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLRF1 Gene

9,827,392 bp from pter
9,845,007 bp from pter
17,616 bases
Plus strand

Genomic View for KLRF1 Gene

Genes around KLRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRF1 Gene

Proteins for KLRF1 Gene

  • Protein details for KLRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell lectin-like receptor subfamily F member 1
    Protein Accession:
    Secondary Accessions:
    • Q4KMT5
    • Q96PR2
    • Q96PR3
    • Q9NZS1

    Protein attributes for KLRF1 Gene

    232 amino acids
    Molecular mass:
    26666 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for KLRF1 Gene


neXtProt entry for KLRF1 Gene

Proteomics data for KLRF1 Gene at MOPED

Post-translational modifications for KLRF1 Gene

  • Glycosylation at Asn 77, Asn 91, Asn 96, and Asn 177
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KLRF1

No data available for DME Specific Peptides for KLRF1 Gene

Domains & Families for KLRF1 Gene

Protein Domains for KLRF1 Gene

Suggested Antigen Peptide Sequences for KLRF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRF1: view

Function for KLRF1 Gene

Molecular function for KLRF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

Gene Ontology (GO) - Molecular Function for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671213
genes like me logo Genes that share ontologies with KLRF1: view
genes like me logo Genes that share phenotypes with KLRF1: view

Animal Model Products

CRISPR Products

miRNA for KLRF1 Gene

miRTarBase miRNAs that target KLRF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRF1 Gene

Localization for KLRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRF1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for KLRF1 Gene COMPARTMENTS Subcellular localization image for KLRF1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10671213
genes like me logo Genes that share ontologies with KLRF1: view

Drugs & Compounds for KLRF1 Gene

No Compound Related Data Available

Transcripts for KLRF1 Gene

mRNA/cDNA for KLRF1 Gene

Unigene Clusters for KLRF1 Gene

Killer cell lectin-like receptor subfamily F, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP8: - - - -

Relevant External Links for KLRF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRF1 Gene

mRNA expression in normal human tissues for KLRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRF1 Gene

This gene is overexpressed in Whole Blood (x23.0) and Spleen (x9.4).

SOURCE GeneReport for Unigene cluster for KLRF1 Gene Hs.183125

mRNA Expression by UniProt/SwissProt for KLRF1 Gene

Tissue specificity: Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.
genes like me logo Genes that share expression patterns with KLRF1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KLRF1 Gene

Orthologs for KLRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC613393 35
  • 80.38 (n)
  • 72.73 (a)
KLRF1 36
  • 72 (a)
(Canis familiaris)
Mammalia KLRF1 35
  • 85.22 (n)
  • 78.7 (a)
KLRF1 36
  • 74 (a)
(Pan troglodytes)
Mammalia KLRF1 35
  • 99.13 (n)
  • 98.27 (a)
KLRF1 36
  • 98 (a)
(Gallus gallus)
Aves BLEC2 36
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
-- 36
  • 27 (a)
-- 36
  • 13 (a)
Species with no ortholog for KLRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRF1 Gene

Gene Tree for KLRF1 (if available)
Gene Tree for KLRF1 (if available)

Paralogs for KLRF1 Gene

Paralogs for KLRF1 Gene

(8) SIMAP similar genes for KLRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KLRF1: view

Variants for KLRF1 Gene

Sequence variations from dbSNP and Humsavar for KLRF1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2232548 - 9,833,319(+) GTATT(G/T)CTAAA intron-variant, nc-transcript-variant, reference, missense
rs2012290 -- 9,845,190(+) TGAGC(A/T)GTGGT downstream-variant-500B
rs253145 -- 9,838,669(-) GTAAA(A/G)AATAG intron-variant
rs7307034 -- 9,843,053(+) ttgca(G/T)gtatg intron-variant
rs16907726 -- 9,832,717(+) GAAAC(A/C)GTTTT intron-variant

Variation tolerance for KLRF1 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KLRF1 Gene

Disorders for KLRF1 Gene

Relevant External Links for KLRF1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRF1 Gene

Publications for KLRF1 Gene

  1. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis. (PMID: 10671213) Roda-Navarro P. … Fernandez-Ruiz E. (Eur. J. Immunol. 2000) 2 3 4 23 67
  2. Molecular characterization of two novel alternative spliced variants of the KLRF1 gene and subcellular distribution of KLRF1 isoforms. (PMID: 11513955) Roda-Navarro P. … Fernandez-Ruiz E. (Biochim. Biophys. Acta 2001) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Attenuated natural killer (NK) cell activation through C-type lectin-like receptor NKp80 is due to an anomalous hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with impaired Syk kinase recruitment capacity. (PMID: 23609447) RA1ckrich T. … Steinle A. (J. Biol. Chem. 2013) 3
  5. Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses. (PMID: 23929856) Klimosch S.N. … Steinle A. (Blood 2013) 3

Products for KLRF1 Gene

Sources for KLRF1 Gene