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KLRD1 Gene

protein-coding   GIFtS: 64
GCID: GC12P010378

Killer Cell Lectin-Like Receptor Subfamily D, Member 1


(Previous symbol: CD94)
Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Killer Cell Lectin-Like Receptor Subfamily D, Member 11 2     NK Cell Receptor2 3
CD941 2 3 5     Natural Killer Cells Antigen CD942
KP432 3     Killer Cell Lectin-Like Receptor Subfamily D Member 13
CD94 Antigen2 3     

External Ids:    HGNC: 63781   Entrez Gene: 38242   Ensembl: ENSG000001345397   OMIM: 6028945   UniProtKB: Q132413   
ORGUL members:         

Export aliases for KLRD1 gene to outside databases

Previous GC identifers: GC12P010143 GC12P010583 GC12P010360 GC12P010351 GC12P010457


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLRD1 Gene:
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete
cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2
family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an
antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an
external C terminus. Three transcript variants encoding two different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for KLRD1 Gene:
KLRD1 (killer cell lectin-like receptor subfamily D, member 1) is a protein-coding gene. Diseases associated with KLRD1 include large granular lymphocyte leukemia, and t-cell large granular lymphocyte leukemia. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is KLRC2.

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241
Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
cytotoxic T-cells

Gene Wiki entry for KLRD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLRD1 gene promoter:
         STAT5B   POU2F1a   HNF-1   SEF-1 (1)   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRD1 promoter sequence
   Search Chromatin IP Primers for KLRD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

KLRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P010378:  view genomic region     (about GC identifiers)

Start:
10,378,657 bp from pter      End:
10,469,850 bp from pter
Size:
91,194 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241 (See protein sequence)
Recommended Name: Natural killer cells antigen CD94  
Size: 179 amino acids; 20513 Da
Subunit: Can form disulfide-bonded heterodimer with NKG2 family members
4 PDB 3D structures from and Proteopedia for KLRD1:
1B6E (3D)        3BDW (3D)        3CDG (3D)        3CII (3D)    
Secondary accessions: O43321 O43773 Q9UBE3 Q9UEQ0
Alternative splicing: 3 isoforms:  Q13241-1   Q13241-2   Q13241-3   

Explore the universe of human proteins at neXtProt for KLRD1: NX_Q13241

Explore proteomics data for KLRD1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn83, Asn132
  • Modification sites at PhosphoSitePlus

  • See KLRD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001107868.1  NP_002253.1  NP_031360.1  

    ENSEMBL proteins: 
     ENSP00000438669   ENSP00000371332   ENSP00000441074   ENSP00000443584   ENSP00000344858  
     ENSP00000438514   ENSP00000437880   ENSP00000371333   ENSP00000338130   ENSP00000310929  
    Reactome Protein details: Q13241

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLR: Killer cell lectin-like receptors
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q13241

    ProtoNet protein and cluster: Q13241

    UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241
    Similarity: Contains 1 C-type lectin domain


    KLRD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLRD1_HUMAN, Q13241
    Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
    cytotoxic T-cells

         Genatlas biochemistry entry for KLRD1:
    natural killer cell lectin-like receptor subfamily D,member 1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS7589107
    GO:0030246carbohydrate binding IEA--
         
    KLRD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLRD1:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klrd1):
     immune system  no phenotypic analysis 

    KLRD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Klrd1tm1.1Lll for KLRD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLRD1
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    hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLRD1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLRD1_HUMAN, Q13241: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    KLRD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLRD1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.33
    2Signaling by FGFR
    DAP12 signaling0.89
    DAP12 interactions0.89
    3Allograft rejection
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for KLRD1
        Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells
    Immune response Role of integrins in NK cells cytotoxicity


    3 Reactome Pathways for KLRD1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    DAP12 interactions
    DAP12 signaling


    3 Kegg Pathways  (Kegg details for KLRD1):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease


    KLRD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLRD1: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLRD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for KLRD1 (Q132413 ENSP000003381304) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237216P176933, ENSP000004091324I2D: score=1 STRING: ENSP00000409132
    HLA-GP176933, ENSP000003534724I2D: score=1 STRING: ENSP00000353472
    ENSG00000206506P176933I2D: score=1 
    ENSG00000230413P176933I2D: score=1 
    ENSG00000233095P176933I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7589107
    GO:0045087innate immune response TAS--
    GO:0050776regulation of immune response TAS--

    KLRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLRD1

    2 Novoseek inferred chemical compound relationships for KLRD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    toxin-1 50.4 1 9448304 (1)
    tyrosine 0.101 3 8816383 (2), 9059895 (1)



    KLRD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLRD1 gene (3 alternative transcripts): 
    NM_001114396.1  NM_002262.3  NM_007334.2  

    Unigene Cluster for KLRD1:

    Killer cell lectin-like receptor subfamily D, member 1
    Hs.562457  [show with all ESTs]
    Unigene Representative Sequence: NM_002262
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544747 ENST00000540271 ENST00000381907 ENST00000538997 ENST00000543420
    ENST00000543777 ENST00000344825 ENST00000539374 ENST00000539792 ENST00000381908(uc001qxz.4)
    ENST00000336164(uc001qxw.4 uc001qxx.4 uc009zhh.3 uc009zhi.3)
    ENST00000350274(uc001qxy.4)

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    2 qRT-PCR Assays for microRNAs that regulate KLRD1:
    hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLRD1 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat KLRD1

    Additional mRNA sequence: 

    AB009597.1 AF498040.1 AF498041.1 AJ000001.1 AK291506.1 AY227806.1 AY327501.1 BC028009.1 
    U30610.1 

    5 DOTS entries:

    DT.452219  DT.100019383  DT.101981229  DT.100751338  DT.95234789 

    23 AceView cDNA sequences:

    AB009597 BI911536 AY227806 BC042884 BX088880 AF498040 U30610 BC028009 
    AJ000001 NM_002262 AU137975 AW295410 CB162507 NM_007334 BI463554 AF498041 
    AA813015 AI300810 BI833040 AU156126 R78286 CD639374 BG537193 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KLRD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                                                  
    SP2:                                      -                           
    SP3:                                -                                 
    SP4:                          -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for KLRD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLRD1 expression in normal human tissues (normalized intensities)      KLRD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCATTCT
    KLRD1 Expression
    About this image


    KLRD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 7 entries
             Natural Killer Cells Peripheral Blood
             Natural killer-like cells
             Cord Blood Natural Killer Cells (CD56+)   
             pbmc   
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Natural Killer Cells (CD56+)   
    KLRD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLRD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.562457

    UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241
    Tissue specificity: Natural killer cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLRD1: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLRD1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrd11 , 5 killer cell lectin-like receptor, subfamily D, member more1, 5 71.78(n)1
    54.55(a)1
      6 (63.42 cM)5
    166431  NM_010654.31  NP_034784.11 
     1295917825 


    ENSEMBL Gene Tree for KLRD1 (if available)
    TreeFam Gene Tree for KLRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLRD1 gene
    KLRC22  KLRK12  KLRC42  KLRC4-KLRK12  ENSG000002556412  KLRC12  KLRC32  
    Selected SIMAP similar genes for KLRD1 using alignment to 9 protein entries:     KLRD1_HUMAN (see all proteins) (see all similar genes):
    FCER2    CLEC12A    CLEC1B    KLRF1    CLEC2D    KLRC1
    CLEC2B    KLRG1    CLEC12B    CLEC1A    CLEC4C    OLR1
    CLEC9A    CD69    KLRC2    KLRC3    CLEC4M    KLRF2

    KLRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLRD1 (see all 350)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73086011,2
    C,F,A,H--10455055(+) tggccG/Attgca 1 -- us2k15Minor allele frequency- A:0.04NS NA WA 374
    rs1460947241,2
    --10455094(+) GTATTA/GTAGCA 1 -- us2k10--------
    rs118380901,2
    C,F,H--10455134(+) cctacT/Gtggta 1 -- us2k16Minor allele frequency- G:0.02NS EA WA 540
    rs796773001,2
    C,F--10455153(+) GTTATC/AACTCA 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1917773381,2
    --10455213(+) GGCAGC/GGGGTT 1 -- us2k10--------
    rs1824633251,2
    --10455227(+) GAATGC/GGTGTT 1 -- us2k10--------
    rs107722551,2
    C,F,A,H--10455250(+) aggggG/Cagtga 1 -- us2k119Minor allele frequency- C:0.29NS EA NA WA CSA 1201
    rs757509141,2
    C,F--10455285(+) CCTCAC/GGAGCT 1 -- us2k11Minor allele frequency- G:0.10WA 118
    rs1397432751,2
    C--10455304(+) CTCTGA/GGTGGG 1 -- us2k10--------
    rs1157557511,2
    F--10455309(+) GGTGGG/TGCCAC 1 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for KLRD1 (10378657 - 10469850 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLRD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898759CNV Loss21882294
    nsv605CNV Loss18451855
    nsv832328CNV Gain17160897
    nsv898757CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602894    OMIM disorders: --

    Selected diseases for KLRD1 (see all 32):    About MalaCards
    large granular lymphocyte leukemia    t-cell large granular lymphocyte leukemia    cytomegalovirus infection    toxic shock syndrome
    toxic epidermal necrolysis    stevens-johnson syndrome    behcet's disease    psoriasis
    vitiligo    celiac disease    uveitis    peritonitis
    lupus erythematosus    graft versus host disease    endometriosis    endometrial carcinoma
    acute myeloid leukemia    rheumatoid arthritis    hepatitis c virus    hepatitis b


    KLRD1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for KLRD1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    toxic shock syndrome 38.9 1 9448304 (1)
    psoriasis 37.1 2 12890211 (2)
    genetic susceptibility 12.8 3 12618865 (1)
    lymphoma t-cell 11.7 5 10828054 (2), 12816864 (1)
    tumors 8.24 3 11169413 (1), 10560910 (1)
    necrosis 5.69 2 19220836 (1)
    cancer 1.9 1 15805295 (1)
    lupus erythematosus systemic 0 3 12618865 (1)
    hiv infections 0 1 11807303 (1)
    rheumatoid arthritis 0 3 12618865 (1)

    Genetic Association Database (GAD): KLRD1
    Human Genome Epidemiology (HuGE) Navigator: KLRD1 (5 documents)

    Export disorders for KLRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLRD1 gene, integrated from 10 sources (see all 168):
    (articles sorted by number of sources associating them with KLRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. (PubMed id 7589107)1, 2, 3 Chang C....Lanier L.L. (Eur. J. Immunol. 1995)
    2. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PubMed id 12618865)1, 4, 9 Hikami K....Tokunaga K. (Genes Immun. 2003)
    3. Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. (PubMed id 10023772)1, 2, 9 Boyington J.C....Sun P.D. (Immunity 1999)
    4. Structure of the human CD94 C-type lectin gene. (PubMed id 9472066)1, 2, 9 Rodriguez A.... Lopez-Botet M. (Immunogenetics 1998)
    5. Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population. (PubMed id 20648603)1, 4 Ma J....Liu Y. (J. Med. Virol. 2010)
    6. CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. (PubMed id 18332182)1, 2 Petrie E.J.... Rossjohn J. (J. Exp. Med. 2008)
    7. Structural basis for NKG2A/CD94 recognition of HLA-E. (PubMed id 18448674)1, 2 Kaiser B.K.... Strong R.K. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. (PubMed id 18083576)1, 2 Sullivan L.C.... Brooks A.G. (Immunity 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A alternatively spliced form of the human CD94 gene. (PubMed id 9601951)1, 2 Furukawa H.... Juji T. (Immunogenetics 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3824 HGNC: 6378 AceView: KLRD1 Ensembl:ENSG00000134539 euGenes: HUgn3824
    ECgene: KLRD1 Kegg: 3824 H-InvDB: KLRD1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLRD1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_238

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLRD1 gene:
    Search GeneIP for patents involving KLRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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