Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLRD1 Gene

protein-coding   GIFtS: 63
GCID: GC12P010378

Killer Cell Lectin-Like Receptor Subfamily D, Member 1


(Previous symbol: CD94)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Lectin-Like Receptor Subfamily D, Member 11 2     NK Cell Receptor2 3
CD941 2 3 5     Natural Killer Cells Antigen CD942
KP432 3     Killer Cell Lectin-Like Receptor Subfamily D Member 13
CD94 Antigen2 3     

External Ids:    HGNC: 63781   Entrez Gene: 38242   Ensembl: ENSG000001345397   OMIM: 6028945   UniProtKB: Q132413   

Export aliases for KLRD1 gene to outside databases

Previous GC identifers: GC12P010143 GC12P010583 GC12P010360 GC12P010351 GC12P010457


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLRD1 Gene:
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete
cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2
family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an
antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an
external C terminus. Three transcript variants encoding two different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for KLRD1 Gene: 
KLRD1 (killer cell lectin-like receptor subfamily D, member 1) is a protein-coding gene. Diseases associated with KLRD1 include toxic shock syndrome, and t-cell large granular lymphocyte leukemia, and among its related super-pathways are Immune response Role of DAP12 receptors in NK cells and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is KLRC2.

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241
Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
cytotoxic T-cells

Gene Wiki entry for KLRD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLRD1 gene promoter:
         STAT5B   POU2F1a   HNF-1   SEF-1 (1)   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLRD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

KLRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P010378:  view genomic region     (about GC identifiers)

Start:
10,378,657 bp from pter      End:
10,469,850 bp from pter
Size:
91,194 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241 (See protein sequence)
Recommended Name: Natural killer cells antigen CD94  
Size: 179 amino acids; 20513 Da
Subunit: Can form disulfide-bonded heterodimer with NKG2 family members
Subcellular location: Membrane; Single-pass type II membrane protein
4 PDB 3D structures from and Proteopedia for KLRD1:
1B6E (3D)        3BDW (3D)        3CDG (3D)        3CII (3D)    
Secondary accessions: O43321 O43773 Q9UBE3 Q9UEQ0
Alternative splicing: 3 isoforms:  Q13241-1   Q13241-2   Q13241-3   

Explore the universe of human proteins at neXtProt for KLRD1: NX_Q13241

Explore proteomics data for KLRD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13241

  • KLRD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLRD1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001107868.1  NP_002253.1  NP_031360.1  

    ENSEMBL proteins: 
     ENSP00000438669   ENSP00000371332   ENSP00000441074   ENSP00000443584   ENSP00000344858  
     ENSP00000438514   ENSP00000437880   ENSP00000371333   ENSP00000338130   ENSP00000310929  
    Reactome Protein details: Q13241
    Human Recombinant Protein Products for KLRD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KLRD1
    OriGene Protein Over-expression Lysate for KLRD1
    OriGene MassSpec for KLRD1 
    OriGene Custom Protein Services for KLRD1
    GenScript Custom Purified and Recombinant Proteins Services for KLRD1
    Novus Biologicals KLRD1 Proteins
    Novus Biologicals KLRD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLRD1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    KLRD1 for ontologies           About GeneDecksing



    KLRD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KLRD1 (CD94)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLRD1
    GenScript Custom Superior Antibodies Services for KLRD1
    Novus Biologicals KLRD1 Antibodies
    Abcam antibodies for KLRD1
    Cloud-Clone Corp. Antibodies for KLRD1 
    ThermoFisher Antibody for KLRD1
    LSBio Antibodies in human, mouse, rat for KLRD1 

    Assay Products for KLRD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLRD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLRD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLRD1 
    Cloud-Clone Corp. CLIAs for KLRD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KLR: Killer cell lectin-like receptors
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q13241

    ProtoNet protein and cluster: Q13241

    UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241
    Similarity: Contains 1 C-type lectin domain


    KLRD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLRD1_HUMAN, Q13241
    Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
    cytotoxic T-cells

         Genatlas biochemistry entry for KLRD1:
    natural killer cell lectin-like receptor subfamily D,member 1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS7589107
    GO:0030246carbohydrate binding IEA--
         
    KLRD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLRD1:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klrd1):
     immune system  no phenotypic analysis 

    KLRD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Klrd1tm1.1Lll for KLRD1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLRD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLRD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLRD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLRD1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLRD1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate KLRD1:
    hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLRD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLRD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLRD1
    Sirion Biotech Customized adenovirus for overexpression of KLRD1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KLRD1 (see all 20)
    OriGene ORF clones in mouse, rat for KLRD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KLRD1 (NM_002262)
    Sino Biological Human cDNA Clone for KLRD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLRD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRD1
    Sirion Biotech Customized lentivirus for stable overexpression of KLRD1 
                         Customized lentivirus expression plasmids for stable overexpression of KLRD1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLRD1
    Search LifeMap BioReagents cell lines for KLRD1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLRD1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Role of DAP12 receptors in NK cells0.32
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.32
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    3Signaling by FGFR
    DAP12 signaling0.91
    DAP12 interactions0.91
    4Allograft rejection
    Graft-versus-host disease0.65
    Antigen processing and presentation0.37
    5Immune response Role of integrins in NK cells cytotoxicity
    Immune response Role of integrins in NK cells cytotoxicity1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for KLRD1
        Immune response Role of integrins in NK cells cytotoxicity
    Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells


    3 GeneGo (Thomson Reuters) Pathways for KLRD1
        Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells
    Immune response Role of integrins in NK cells cytotoxicity


    5/6        Reactome Pathways for KLRD1 (see all 6)
        DAP12 interactions
    DAP12 signaling
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    3         Kegg Pathways  (Kegg details for KLRD1):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease


    KLRD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLRD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/24 Interacting proteins for KLRD1 (Q132413 ENSP000003381304) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237216P176933, ENSP000004091324I2D: score=1 STRING: ENSP00000409132
    HLA-GP176933, ENSP000003534724I2D: score=1 STRING: ENSP00000353472
    ENSG00000206506P176933I2D: score=1 
    ENSG00000230413P176933I2D: score=1 
    ENSG00000233095P176933I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7589107
    GO:0045087innate immune response TAS--
    GO:0050776regulation of immune response TAS--

    KLRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLRD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLRD1

    2 Novoseek inferred chemical compound relationships for KLRD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    toxin-1 50.4 1 9448304 (1)
    tyrosine 0.101 3 8816383 (2), 9059895 (1)

    Search CenterWatch for drugs/clinical trials and news about KLRD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLRD1 gene (3 alternative transcripts): 
    NM_001114396.1  NM_002262.3  NM_007334.2  

    Unigene Cluster for KLRD1:

    Killer cell lectin-like receptor subfamily D, member 1
    Hs.562457  [show with all ESTs]
    Unigene Representative Sequence: NM_002262
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544747 ENST00000540271 ENST00000381907 ENST00000538997 ENST00000543420
    ENST00000543777 ENST00000344825 ENST00000539374 ENST00000539792 ENST00000381908(uc001qxz.4)
    ENST00000336164(uc001qxw.4 uc001qxx.4 uc009zhh.3 uc009zhi.3)
    ENST00000350274(uc001qxy.4)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLRD1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate KLRD1:
    hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLRD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLRD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRD1
    Clone
    Products:
         
    OriGene clones in human, mouse for KLRD1 (see all 20)
    OriGene ORF clones in mouse, rat for KLRD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KLRD1 (NM_002262)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLRD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRD1
    Sirion Biotech Customized lentivirus for stable overexpression of KLRD1 
                         Customized lentivirus expression plasmids for stable overexpression of KLRD1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLRD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLRD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRD1

    Additional mRNA sequence: 

    AB009597.1 AF498040.1 AF498041.1 AJ000001.1 AK291506.1 AY227806.1 AY327501.1 BC028009.1 
    U30610.1 

    5 DOTS entries:

    DT.452219  DT.100019383  DT.101981229  DT.100751338  DT.95234789 

    23 AceView cDNA sequences:

    AB009597 AU137975 NM_002262 AF498041 BC028009 AI300810 BC042884 AJ000001 
    AY227806 AA813015 BX088880 U30610 BI463554 BI911536 AF498040 CB162507 
    NM_007334 AW295410 BI833040 R78286 AU156126 CD639374 BG537193 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KLRD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                                                  
    SP2:                                      -                           
    SP3:                                -                                 
    SP4:                          -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for KLRD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLRD1 expression in normal human tissues (normalized intensities)      KLRD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCATTCT
    KLRD1 Expression
    About this image


    KLRD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Common Dendritic Cell Precursors Hematopoietic Bone Marrow
             Natural killer-like cells ( Derivation of hematopoietic progenitor cells and natural...
             Cord Blood Natural Killer Cells (CD56+)   
             pbmc   
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Natural Killer Cells (CD56+)   
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen

    See KLRD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLRD1

    SOURCE GeneReport for Unigene cluster: Hs.562457

    UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241
    Tissue specificity: Natural killer cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including KLRD1: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLRD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLRD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLRD1 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrd11 , 5 killer cell lectin-like receptor, subfamily D, member more1, 5 71.78(n)1
    54.55(a)1
      6 (63.42 cM)5
    166431  NM_010654.31  NP_034784.11 
     1295917825 
    chicken
    (Gallus gallus)
    Aves KLRD16
    killer cell lectin-like receptor subfamily D, memb...
    18(a)
    1 ↔ 1
    1(77917404-77926160)


    ENSEMBL Gene Tree for KLRD1 (if available)
    TreeFam Gene Tree for KLRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLRD1 gene
    KLRC22  KLRK12  KLRC42  KLRC4-KLRK12  ENSG000002556412  KLRC12  KLRC32  
    18 SIMAP similar genes for KLRD1 using alignment to 9 protein entries:     KLRD1_HUMAN (see all proteins):
    FCER2    CLEC12A    CLEC2D    CLEC1B    KLRF1    KLRC1
    CLEC2B    KLRG1    CLEC12B    CLEC1A    CLEC4C    OLR1
    CLEC9A    CD69    KLRC2    KLRC3    CLEC4M    KLRF2

    KLRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/350 SNPs in KLRD1 are shown (see all 350)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73086011,2
    C,F,A,H--10455055(+) tggccG/Attgca 1 -- us2k15Minor allele frequency- A:0.04NS NA WA 374
    rs1460947241,2
    --10455094(+) GTATTA/GTAGCA 1 -- us2k10--------
    rs118380901,2
    C,F,H--10455134(+) cctacT/Gtggta 1 -- us2k16Minor allele frequency- G:0.02NS EA WA 540
    rs796773001,2
    C,F--10455153(+) GTTATC/AACTCA 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1917773381,2
    --10455213(+) GGCAGC/GGGGTT 1 -- us2k10--------
    rs1824633251,2
    --10455227(+) GAATGC/GGTGTT 1 -- us2k10--------
    rs107722551,2
    C,F,A,H--10455250(+) aggggG/Cagtga 1 -- us2k119Minor allele frequency- C:0.29NS EA NA WA CSA 1201
    rs757509141,2
    C,F--10455285(+) CCTCAC/GGAGCT 1 -- us2k11Minor allele frequency- G:0.10WA 118
    rs1397432751,2
    C--10455304(+) CTCTGA/GGTGGG 1 -- us2k10--------
    rs1157557511,2
    F--10455309(+) GGTGGG/TGCCAC 1 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for KLRD1 (10378657 - 10469850 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLRD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898759CNV Loss21882294
    nsv605CNV Loss18451855
    nsv832328CNV Gain17160897
    nsv898757CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for KLRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602894    OMIM disorders: --

    20/31 diseases for KLRD1 (see all 31):    About MalaCards
    toxic shock syndrome    t-cell large granular lymphocyte leukemia    large granular lymphocyte leukemia    toxic epidermal necrolysis
    stevens-johnson syndrome    cytomegalovirus infection    behcet's disease    vitiligo
    psoriasis    uveitis    celiac disease    chronic obstructive pulmonary disease
    peritonitis    graft versus host disease    endometriosis    endometrial carcinoma
    acute myeloid leukemia    rheumatoid arthritis    hepatitis b    hepatitis c


    KLRD1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/12 Novoseek inferred disease relationships for KLRD1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    toxic shock syndrome 38.9 1 9448304 (1)
    psoriasis 37.1 2 12890211 (2)
    genetic susceptibility 12.8 3 12618865 (1)
    lymphoma t-cell 11.7 5 10828054 (2), 12816864 (1)
    tumors 8.24 3 11169413 (1), 10560910 (1)
    necrosis 5.69 2 19220836 (1)
    cancer 1.9 1 15805295 (1)
    lupus erythematosus systemic 0 3 12618865 (1)
    hiv infections 0 1 11807303 (1)
    rheumatoid arthritis 0 3 12618865 (1)

    Genetic Association Database (GAD): KLRD1
    Human Genome Epidemiology (HuGE) Navigator: KLRD1 (5 documents)

    Export disorders for KLRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLRD1 gene, integrated from 9 sources (see all 166):
    (articles sorted by number of sources associating them with KLRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. (PubMed id 7589107)1, 2, 3 Chang C....Lanier L.L. (1995)
    2. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PubMed id 12618865)1, 4, 9 Hikami K....Tokunaga K. (2003)
    3. Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. (PubMed id 10023772)1, 2, 9 Boyington J.C....Sun P.D. (1999)
    4. Structure of the human CD94 C-type lectin gene. (PubMed id 9472066)1, 2, 9 Rodriguez A.... Lopez-Botet M. (1998)
    5. Association of NKG2D genetic polymorphism with suscep tibility to chronic hepatitis B in a Han Chinese population. (PubMed id 20648603)1, 4 Ma J....Liu Y. (2010)
    6. CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. (PubMed id 18332182)1, 2 Petrie E.J....Rossjohn J. (2008)
    7. Structural basis for NKG2A/CD94 recognition of HLA-E. (PubMed id 18448674)1, 2 Kaiser B.K....Strong R.K. (2008)
    8. The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. (PubMed id 18083576)1, 2 Sullivan L.C....Brooks A.G. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. A alternatively spliced form of the human CD94 gene. (PubMed id 9601951)1, 2 Furukawa H.... Juji T. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3824 HGNC: 6378 AceView: KLRD1 Ensembl:ENSG00000134539 euGenes: HUgn3824
    ECgene: KLRD1 Kegg: 3824 H-InvDB: KLRD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLRD1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_238

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLRD1 gene:
    Search GeneIP for patents involving KLRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KLRD1 (CD94)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLRD1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KLRD1  
     OriGene MassSpec something-or-other for KLRD1   OriGene clones in human, mouse for KLRD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLRD1   OriGene Purified Protein for KLRD1  
     OriGene ORF clones in mouse, rat for KLRD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLRD1   OriGene Custom Protein Services for KLRD1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLRD1
     QIAGEN SeqTarget long-range PCR primers for resequencing KLRD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRD1
     GenScript Custom Purified and Recombinant Proteins Services for KLRD1 GenScript cDNA clones with any tag delivered in your preferred vector for KLRD1
     GenScript Custom Assay Services for KLRD1 GenScript Custom Superior Antibodies Services for KLRD1
     GenScript Custom overexpressing Cell Line Services for KLRD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLRD1 promoter
     Search Chromatin IP Primers for KLRD1
     RT2 qPCR Primer Assay in human, mouse, rat KLRD1
     GNC Network for KLRD1
     SABiosciences PCR Arrays including human, mouse, rat KLRD1
     Search Tocris compounds for KLRD1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for KLRD1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLRD1 antibodies
     KLRD1 proteins
     KLRD1 lysates
     Antibodies for KLRD1
     See all of Abcam's Antibodies, Kits and Proteins for KLRD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KLRD1
     Antibodies for KLRD1
     ELISAs for KLRD1
     CLIAs for KLRD1
     Search LifeMap BioReagents cell lines for KLRD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRD1
     SwitchGear 3'UTR luciferase reporter plasmids for KLRD1
     SwitchGear Promoter luciferase reporter plasmids for KLRD1
     ThermoFisher Antibody for KLRD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRD1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KLRD1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLRD1
    Customized:
     lentivirus for stable overexpression of KLRD1
     lentivirus expression plasmids for stable overexpression of KLRD1
     adenovirus for overexpression of KLRD1
     LSBio Antibodies in human, mouse, rat for KLRD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLRD1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4