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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLRD1 Gene

protein-coding GIFtS: 62
GCID: GC12P010378

killer cell lectin-like receptor subfamily D, member 1

(Previous symbol: CD94)

Explore 36 diseases affiliated with
KLRD1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Killer Cell Lectin-Like Receptor Subfamily D, Member 1¹ ²		NK Cell Receptor² ³
CD94¹ ² ³ ⁵		Natural Killer Cells Antigen CD94²
KP43² ³		Killer Cell Lectin-Like Receptor Subfamily D Member 1³
CD94 Antigen² ³

External Ids:	HGNC: 6378¹	Entrez Gene: 3824²	Ensembl: ENSG00000134539⁷	OMIM: 602894⁵	UniProtKB: Q13241³

Export aliases for KLRD1 gene to outside databases

Previous GC identifers: GC12P010143 GC12P010583 GC12P010360 GC12P010351 GC12P010457

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLRD1:

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines

upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are

expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen

preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C

terminus. Three transcript variants encoding two different isoforms have been found for this gene. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241

Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic

T-cells

Gene Wiki entry for KLRD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLRD1 gene promoter:
STAT5B POU2F1a HNF-1 SEF-1 (1) HNF-1A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLRD1 promoter sequence

Search SABiosciences Chromatin IP Primers for KLRD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13

KLRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRD1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P010378: view genomic region (about GC identifiers)

Start:	10,378,657 bp from pter	End:	10,469,850 bp from pter
Size:	91,194 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241 (See protein sequence)

Recommended Name: Natural killer cells antigen CD94

Size: 179 amino acids; 20513 Da

Subunit: Can form disulfide-bonded heterodimer with NKG2 family members

Subcellular location: Membrane; Single-pass type II membrane protein

4 PDB 3D structures from and Proteopedia for KLRD1:

1B6E (3D)

3BDW (3D)

3CDG (3D)

3CII (3D)

Secondary accessions: O43321 O43773 Q9UBE3 Q9UEQ0

Alternative splicing: 3 isoforms: Q13241-1 Q13241-2 Q13241-3

Explore the universe of human proteins at neXtProt for KLRD1: NX_Q13241

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13241

KLRD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001107868.1 NP_002253.1 NP_031360.1

ENSEMBL proteins:

ENSP00000438669 ENSP00000371332 ENSP00000441074 ENSP00000443584 ENSP00000344858

ENSP00000438514 ENSP00000437880 ENSP00000371333 ENSP00000338130 ENSP00000310929

Reactome Protein details: Q13241
Human Recombinant Protein Products:

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	Novus Biologicals KLRD1 Proteins Novus Biologicals KLRD1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KLRD1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

KLRD1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KLRD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLRD1 for domains About GeneDecksing

3 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q13241

ProtoNet protein and cluster: Q13241

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241

Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic

T-cells

Genatlas biochemistry entry for KLRD1:

natural killer cell lectin-like receptor subfamily D,member 1

miRNA Products:		OriGene 3'-UTR Clone (see all 3): KLRD1 Browse MicroRNA Expression Plasmids
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		hsa-miR-3919 hsa-miR-590-3p
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KLRD1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLRD1
		Search LifeMap BioReagents cell lines for KLRD1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRD1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	7589107
GO:0030246	carbohydrate binding	IEA	--

KLRD1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KLRD1:

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Klrd1^tm1.1Lll for KLRD1
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Klrd1):

immune system

no phenotypic analysis

KLRD1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response CD16 signaling in NK cells

	Immune response CD16 signaling in NK cells	1.00			Immune response_Role of DAP12 receptors in NK cells	0.32
	Immune response_CD16 signaling in NK cells	0.99			Immune response Role of DAP12 receptors in NK cells	0.32

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Signaling by FGFR

DAP12 signaling

0.83

DAP12 interactions

0.76

Allograft rejection

Graft-versus-host disease

0.63

Antigen processing and presentation

0.25

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

Immune response Role of integrins in NK cells cytotoxicity

0.28

Immune response_Role of integrins in NK cells cytotoxicity

0.28

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for KLRD1

	Immune response Role of integrins in NK cells cytotoxicity
	Immune response CD16 signaling in NK cells
	Immune response Role of DAP12 receptors in NK cells

3 GeneGo (Thomson Reuters) Pathways for KLRD1

	Immune response CD16 signaling in NK cells
	Immune response Role of DAP12 receptors in NK cells
	Immune response Role of integrins in NK cells cytotoxicity

5/6 Reactome Pathways for KLRD1 (see all 6)

	DAP12 interactions
	DAP12 signaling
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Immune System

3 Kegg Pathways (Kegg details for KLRD1):

	Antigen processing and presentation
	Natural killer cell mediated cytotoxicity
	Graft-versus-host disease

KLRD1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLRD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/17 Interacting proteins for KLRD1 (Q13241³ ENSP00000338130⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KLRC1	P26715³, ENSP00000352064⁴	I2D: score=3 STRING: ENSP00000352064
HLA-B	P01889³, ENSP00000399168⁴	I2D: score=1 STRING: ENSP00000399168
TYROBP	O43914³, ENSP00000262629⁴	I2D: score=1 STRING: ENSP00000262629
KLRC2	P26717³, ENSP00000371327⁴	I2D: score=1 STRING: ENSP00000371327
KLRC3	Q07444³, ENSP00000371328⁴	I2D: score=3 STRING: ENSP00000371328

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor signaling pathway	TAS	7589107
GO:0050776	regulation of immune response	TAS	--

KLRD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KLRD1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLRD1
2 Novoseek chemical compound relationships for KLRD1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
toxin-1	50.4	1	9448304 (1)
tyrosine	0.101	3	8816383 (2), 9059895 (1)

Search CenterWatch for drugs/clinical trials and news about KLRD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLRD1 gene (3 alternative transcripts):

NM_001114396.1 NM_002262.3 NM_007334.2

Unigene Cluster for KLRD1:

Killer cell lectin-like receptor subfamily D, member 1

Hs.562457 [show with all ESTs]

Unigene Representative Sequence: NM_002262

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000544747 ENST00000540271 ENST00000381907 ENST00000538997 ENST00000543420

ENST00000543777 ENST00000344825 ENST00000539374 ENST00000539792 ENST00000381908(uc001qxz.4)

ENST00000336164(uc001qxw.4 uc001qxx.4 uc009zhh.3 uc009zhi.3)

ENST00000350274(uc001qxy.4)

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		hsa-miR-3919 hsa-miR-590-3p
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRD1

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Additional cDNA sequence:

AB009597.1 AF498040.1 AF498041.1 AJ000001.1 AK291506.1 AY227806.1 AY327501.1 BC028009.1

U30610.1

5 DOTS entries:

DT.452219 DT.100019383 DT.101981229 DT.100751338 DT.95234789

23 AceView cDNA sequences:

AB009597 AA813015 AF498041 AF498040 AI300810 AY227806 AW295410 BX088880

U30610 AU137975 NM_002262 CB162507 BI911536 AJ000001 BC042884 BC028009

NM_007334 BI463554 AU156126 R78286 BI833040 CD639374 BG537193

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KLRD1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:
SP2:													-
SP3:											-
SP4:									-
SP5:

ECgene alternative splicing isoforms for KLRD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLRD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCATTCT

About this image

KLRD1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Natural killer-like cells (Derivation of hemato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KLRD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLRD1

SOURCE GeneReport for Unigene cluster: Hs.562457

UniProtKB/Swiss-Prot: KLRD1_HUMAN, Q13241

Tissue specificity: Natural killer cells

SABiosciences Expression via Pathway-Focused PCR Arrays including KLRD1:

HIV Host Response in human mouse rat

Cell Surface Markers in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KLRD1 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CLEC9A⁶	--	32(a)	1 → many	2(81818136-81823316)

ENSEMBL Gene Tree for KLRD1 (if available)
TreeFam Gene Tree for KLRD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLRD1 gene

CLEC9A² OLR1² KLRC2² ENSG00000255819² CLEC12A² KLRC3² CLEC1A² KLRK1²

KLRC4² CLEC1B² ENSG00000255641² CLEC7A² KLRC1² CLEC12B²

18/20 SIMAP similar genes for KLRD1 using alignment to 9 protein entries: KLRD1_HUMAN (see all proteins) (see all similar genes):

FCER2 CLEC12A CLEC2D CLEC1B KLRF1 KLRC1

CLEC2B KLRG1 CLEC12B CLEC1A CLEC4C OLR1

CLEC9A CD69 KLRC2 KLRC3 CLEC4M KLRF2

KLRD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7308601^1,2	C,F,A,H,	--	10455055(+)	`tggccG/Attgca`	1	--	us2k¹		5		NS NA WA	374
rs146094724^1,2		--	10455094(+)	`GTATTA/GTAGCA`	1	--	us2k¹		0	--	--	--	--
rs11838090^1,2	C,F,H,	--	10455134(+)	`cctacT/Gtggta`	1	--	us2k¹		6		NS EA WA	540
rs79677300^1,2	F,	--	10455153(+)	`GTTATC/AACTCA`	1	--	us2k¹		1		WA	118
rs191777338^1,2		--	10455213(+)	`GGCAGC/GGGGTT`	1	--	us2k¹		0	--	--	--	--
rs182463325^1,2		--	10455227(+)	`GAATGC/GGTGTT`	1	--	us2k¹		0	--	--	--	--
rs10772255^1,2	C,F,A,H,	--	10455250(+)	`AGGGGG/CAGTGA`	1	--	us2k¹		19		NS EA NA WA CSA	1201
rs75750914^1,2	F,	--	10455285(+)	`CCTCAC/GGAGCT`	1	--	us2k¹		1		WA	118
rs139743275^1,2		--	10455304(+)	`CTCTGA/GGTGGG`	1	--	us2k¹		0	--	--	--	--
rs115755751^1,2	F,	--	10455309(+)	`GGTGGG/TGCCAC`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for KLRD1 (10378657 - 10469850 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLRD1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRD1

DNA2.0 Custom Variant and Variant Library Synthesis for KLRD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLRD1 for disorders           About GeneDecksing

OMIM gene information: 602894    OMIM disorders: --

20/36 diseases for KLRD1 (see all 36):    About MalaCards

large granular lymphocyte leukemia toxic epidermal necrolysis stevens-johnson syndrome t-cell large granular lymphocyte leukemia

graft versus host disease toxic shock syndrome bcg infection infectious mononucleosis

chronic obstructive pulmonary disease lymphocytic leukemia lupus erythematosus cytomegalovirus infection

rheumatoid arthritis acute myeloid leukemia myeloid leukemia behcet's disease

pulmonary disease celiac disease multiple sclerosis hepatitis c

10/12 Novoseek disease relationships for KLRD1 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
toxic shock syndrome	38.9	1	9448304 (1)
psoriasis	37.1	2	12890211 (2)
genetic susceptibility	12.8	3	12618865 (1)
lymphoma t-cell	11.7	5	10828054 (2), 12816864 (1)
tumors	8.24	3	11169413 (1), 10560910 (1)
necrosis	5.69	2	19220836 (1)
cancer	1.9	1	15805295 (1)
lupus erythematosus systemic	0	3	12618865 (1)
hiv infections	0	1	11807303 (1)
rheumatoid arthritis	0	3	12618865 (1)

Genetic Association Database (GAD): KLRD1
Human Genome Epidemiology (HuGE) Navigator: KLRD1 (5 documents)

Export disorders for KLRD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KLRD1 gene, integrated from 9 sources (see all 166):
(articles sorted by number of sources associating them with KLRD1)

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Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. (PubMed id 7589107)^{1, 2, 3} Chang C....Lanier L.L. (1995)
Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PubMed id 12618865)^{1, 4, 9} Hikami K....Tokunaga K. (2003)
Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. (PubMed id 10023772)^{1, 2, 9} Boyington J.C....Sun P.D. (1999)
Structure of the human CD94 C-type lectin gene. (PubMed id 9472066)^{1, 2, 9} Rodriguez A.... Lopez-Botet M. (1998)
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. (PubMed id 18332182)^{1, 2} Petrie E.J....Rossjohn J. (2008)
Structural basis for NKG2A/CD94 recognition of HLA-E. (PubMed id 18448674)^{1, 2} Kaiser B.K....Strong R.K. (2008)
The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. (PubMed id 18083576)^{1, 2} Sullivan L.C....Brooks A.G. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A alternatively spliced form of the human CD94 gene. (PubMed id 9601951)^{1, 2} Furukawa H.... Juji T. (1998)
Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. (PubMed id 8046333)^{1, 9} Moretta A....Moretta L. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3824	HGNC: 6378	AceView: KLRD1	Ensembl:ENSG00000134539	euGenes: HUgn3824
ECgene: KLRD1	Kegg: 3824	H-InvDB: KLRD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KLRD1	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_238

Intellectual Property for KLRD1 gene
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killer cell lectin-like receptor subfamily D, member 1

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killer cell lectin-like receptor subfamily D, member 1

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