Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLRD1 Gene

Aliases for KLRD1 Gene

  • Killer Cell Lectin Like Receptor D1 2 3
  • Killer Cell Lectin-Like Receptor Subfamily D, Member 1 2 3 5
  • NK Cell Receptor 3 4
  • CD94 Antigen 3 4
  • CD94 3 4
  • KP43 3 4
  • Killer Cell Lectin-Like Receptor Subfamily D Member 1 4

External Ids for KLRD1 Gene

Previous HGNC Symbols for KLRD1 Gene

  • CD94

Previous GeneCards Identifiers for KLRD1 Gene

  • GC12P010143
  • GC12P010583
  • GC12P010360
  • GC12P010351
  • GC12P010457
  • GC12P010378

Summaries for KLRD1 Gene

Entrez Gene Summary for KLRD1 Gene

  • Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRD1 Gene

KLRD1 (Killer Cell Lectin Like Receptor D1) is a Protein Coding gene. Diseases associated with KLRD1 include Large Granular Lymphocyte Leukemia and Behcet's Disease. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity and MHC class I protein complex binding. An important paralog of this gene is KLRC1.

UniProtKB/Swiss-Prot for KLRD1 Gene

  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Gene Wiki entry for KLRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRD1 Gene

Genomics for KLRD1 Gene

Regulatory Elements for KLRD1 Gene

Enhancers for KLRD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLRD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLRD1 Gene

10,226,058 bp from pter
10,360,876 bp from pter
134,819 bases
Plus strand

Genomic View for KLRD1 Gene

Genes around KLRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRD1 Gene

Proteins for KLRD1 Gene

  • Protein details for KLRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Natural killer cells antigen CD94
    Protein Accession:
    Secondary Accessions:
    • O43321
    • O43773
    • Q9UBE3
    • Q9UEQ0

    Protein attributes for KLRD1 Gene

    179 amino acids
    Molecular mass:
    20513 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with NKG2 family members.

    Three dimensional structures from OCA and Proteopedia for KLRD1 Gene

    Alternative splice isoforms for KLRD1 Gene


neXtProt entry for KLRD1 Gene

Proteomics data for KLRD1 Gene at MOPED

Post-translational modifications for KLRD1 Gene

  • Glycosylation at Asn 83 and Asn 132
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CD94
  • Cloud-Clone Corp. Antibodies for KLRD1

No data available for DME Specific Peptides for KLRD1 Gene

Domains & Families for KLRD1 Gene

Gene Families for KLRD1 Gene

Protein Domains for KLRD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRD1: view

Function for KLRD1 Gene

Molecular function for KLRD1 Gene

GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily D,member 1
UniProtKB/Swiss-Prot Function:
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Gene Ontology (GO) - Molecular Function for KLRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0023030 MHC class Ib protein binding, via antigen binding groove IPI 25631937
GO:1990405 protein antigen binding IDA 18448674
genes like me logo Genes that share ontologies with KLRD1: view

Phenotypes for KLRD1 Gene

genes like me logo Genes that share phenotypes with KLRD1: view

Animal Models for KLRD1 Gene

MGI Knock Outs for KLRD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for KLRD1

CRISPR Products

miRNA for KLRD1 Gene

miRTarBase miRNAs that target KLRD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLRD1 Gene

Localization for KLRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRD1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for KLRD1 Gene COMPARTMENTS Subcellular localization image for KLRD1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for KLRD1 Gene

Pathways & Interactions for KLRD1 Gene

genes like me logo Genes that share pathways with KLRD1: view

Gene Ontology (GO) - Biological Process for KLRD1 Gene


No data available for SIGNOR curated interactions for KLRD1 Gene

Drugs & Compounds for KLRD1 Gene

(1) Drugs for KLRD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLRD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLRD1: view

Transcripts for KLRD1 Gene

Unigene Clusters for KLRD1 Gene

Killer cell lectin-like receptor subfamily D, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP2: -
SP3: -
SP4: -

Relevant External Links for KLRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRD1 Gene

mRNA expression in normal human tissues for KLRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRD1 Gene

This gene is overexpressed in Whole Blood (x28.5) and Spleen (x6.6).

Protein differential expression in normal tissues from HIPED for KLRD1 Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLRD1 Gene

SOURCE GeneReport for Unigene cluster for KLRD1 Gene Hs.562457

mRNA Expression by UniProt/SwissProt for KLRD1 Gene

Tissue specificity: Natural killer cells.
genes like me logo Genes that share expression patterns with KLRD1: view

Protein tissue co-expression partners for KLRD1 Gene

- Elite partner

Primer Products

Orthologs for KLRD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLRD1 35
  • 75.81 (n)
  • 65.71 (a)
-- 36
  • 59 (a)
-- 36
  • 28 (a)
KLRD1 36
  • 58 (a)
(Canis familiaris)
Mammalia KLRD1 35
  • 76.91 (n)
  • 59.78 (a)
KLRD1 36
  • 60 (a)
(Mus musculus)
Mammalia Klrd1 35
  • 71.78 (n)
  • 54.55 (a)
Klrd1 16
Klrd1 36
  • 54 (a)
(Pan troglodytes)
Mammalia KLRD1 35
  • 99.63 (n)
  • 99.44 (a)
KLRD1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Klrd1 35
  • 70.45 (n)
  • 55.11 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
-- 36
  • 29 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 35 (a)
-- 36
  • 25 (a)
-- 36
  • 17 (a)
-- 36
  • 20 (a)
-- 36
  • 18 (a)
-- 36
  • 28 (a)
-- 36
  • 21 (a)
-- 36
  • 30 (a)
-- 36
  • 19 (a)
-- 36
  • 30 (a)
-- 36
  • 27 (a)
-- 36
  • 22 (a)
-- 36
  • 20 (a)
-- 36
  • 18 (a)
-- 36
  • 30 (a)
-- 36
  • 18 (a)
-- 36
  • 27 (a)
-- 36
  • 18 (a)
-- 36
  • 38 (a)
-- 36
  • 39 (a)
Species with no ortholog for KLRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRD1 Gene

Gene Tree for KLRD1 (if available)
Gene Tree for KLRD1 (if available)

Paralogs for KLRD1 Gene

Paralogs for KLRD1 Gene

genes like me logo Genes that share paralogs with KLRD1: view

Variants for KLRD1 Gene

Sequence variations from dbSNP and Humsavar for KLRD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10772256 - 10,309,453(+) TGATG(G/T)CTACG intron-variant, reference, missense
rs1947763 -- 10,357,317(+) catat(A/G)catat intron-variant
rs1947764 -- 10,357,602(+) acgag(A/G)cattc intron-variant
rs1947765 -- 10,327,537(-) atgca(A/G)aaatc intron-variant
rs2045882 -- 10,358,642(+) gccca(A/G)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRD1 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv832328 CNV Gain 17160897
nsv605 CNV Loss 18451855
nsv898759 CNV Loss 21882294

Variation tolerance for KLRD1 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLRD1 Gene

Disorders for KLRD1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLRD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
large granular lymphocyte leukemia
  • t-cell large granular lymphocyte leukemia
behcet's disease
  • adamantiades-behcet disease
mhc class i deficiency
  • bare lymphocyte syndrome, type i
- elite association - COSMIC cancer census association via MalaCards
Search KLRD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLRD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KLRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLRD1 Gene

Publications for KLRD1 Gene

  1. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. (PMID: 7589107) Chang C. … Lanier L.L. (Eur. J. Immunol. 1995) 2 3 4 67
  2. NKG2D and CD94 bind to multimeric alpha2,3-linked N-acetylneuraminic acid. (PMID: 19303396) Imaizumi Y. … Matsumoto K. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B. (PMID: 16237464) Lieto L.D. … Coligan J.E. (Genes Immun. 2006) 3 23
  4. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PMID: 12618865) Hikami K. … Tokunaga K. (Genes Immun. 2003) 3 23
  5. Human CD94 gene expression: dual promoters differing in responsiveness to IL-2 or IL-15. (PMID: 14607929) Lieto L.D. … Coligan J.E. (J. Immunol. 2003) 3 23

Products for KLRD1 Gene

Sources for KLRD1 Gene