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Aliases for KLRC4-KLRK1 Gene

Aliases for KLRC4-KLRK1 Gene

  • KLRC4-KLRK1 Readthrough 2 3

External Ids for KLRC4-KLRK1 Gene

Previous GeneCards Identifiers for KLRC4-KLRK1 Gene

  • GC12U901579
  • GC12M010526
  • GC12M010618

Summaries for KLRC4-KLRK1 Gene

Entrez Gene Summary for KLRC4-KLRK1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]

GeneCards Summary for KLRC4-KLRK1 Gene

KLRC4-KLRK1 (KLRC4-KLRK1 Readthrough) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Malaria. GO annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is KLRC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC4-KLRK1 Gene

Genomics for KLRC4-KLRK1 Gene

Genomic Location for KLRC4-KLRK1 Gene

Start:
10,372,353 bp from pter
End:
10,410,146 bp from pter
Size:
37,794 bases
Orientation:
Minus strand

Genomic View for KLRC4-KLRK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRC4-KLRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC4-KLRK1 Gene

No data available for Regulatory Elements for KLRC4-KLRK1 Gene

Proteins for KLRC4-KLRK1 Gene

  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024RAP8
    Recommended name:
    HCG2009644, isoform CRA_b
    Protein Accession:
    A0A024RAP8
    Secondary Accessions:

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    216 amino acids
    Molecular mass:
    25304 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BQV0
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    H3BQV0
    Secondary Accessions:

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    150 amino acids
    Molecular mass:
    17279 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BRK7
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    H3BRK7
    Secondary Accessions:

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    37 amino acids
    Molecular mass:
    4700 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BU71
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    H3BU71
    Secondary Accessions:

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    75 amino acids
    Molecular mass:
    8976 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    K7EPB6
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    K7EPB6
    Secondary Accessions:

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    35 amino acids
    Molecular mass:
    4367 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLRC4-KLRK1 Gene

Proteomics data for KLRC4-KLRK1 Gene at MOPED

Post-translational modifications for KLRC4-KLRK1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KLRC4-KLRK1 Gene

Domains for KLRC4-KLRK1 Gene

Protein Domains for KLRC4-KLRK1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRC4-KLRK1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KLRC4-KLRK1 Gene

Function for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Molecular Function for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 2007850
GO:0005515 protein binding IPI 10426993
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLRC4-KLRK1 Gene

Localization for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Cellular Components for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2007850
GO:0009986 cell surface IDA 10426994
GO:0016021 integral component of membrane TAS 9683661
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KLRC4-KLRK1 Gene

Pathways for KLRC4-KLRK1 Gene

genes like me logo Genes that share pathways with KLRC4-KLRK1: view

Pathways by source for KLRC4-KLRK1 Gene

2 KEGG pathways for KLRC4-KLRK1 Gene

Interacting Proteins for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Biological Process for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2007850
GO:0030101 natural killer cell activation TAS 18676862
GO:0030154 cell differentiation IEA --
GO:0031295 T cell costimulation TAS 18676862
GO:0034260 negative regulation of GTPase activity IDA 22585739
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

Transcripts for KLRC4-KLRK1 Gene

mRNA/cDNA for KLRC4-KLRK1 Gene

(1) REFSEQ mRNAs :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC4-KLRK1 Gene

No ASD Table

Relevant External Links for KLRC4-KLRK1 Gene

GeneLoc Exon Structure for
KLRC4-KLRK1
ECgene alternative splicing isoforms for
KLRC4-KLRK1

Expression for KLRC4-KLRK1 Gene

mRNA expression in normal human tissues for KLRC4-KLRK1 Gene

mRNA differential expression in normal tissues according to GTEx for KLRC4-KLRK1 Gene

This gene is overexpressed in Whole Blood (5.4) and Spleen (5.3).
genes like me logo Genes that share expressions with KLRC4-KLRK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KLRC4-KLRK1 Gene

Orthologs for KLRC4-KLRK1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC4-KLRK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRC4 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLRC1 36
  • 29 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Klri2 36
  • 12 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 5 (a)
OneToMany
Species with no ortholog for KLRC4-KLRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC4-KLRK1 Gene

ENSEMBL:
Gene Tree for KLRC4-KLRK1 (if available)
TreeFam:
Gene Tree for KLRC4-KLRK1 (if available)

Paralogs for KLRC4-KLRK1 Gene

Paralogs for KLRC4-KLRK1 Gene

Selected SIMAP similar genes for KLRC4-KLRK1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KLRC4-KLRK1: view

Variants for KLRC4-KLRK1 Gene

Sequence variations from dbSNP and Humsavar for KLRC4-KLRK1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs728010 -- 10,400,668(-) atcta(C/T)gctct intron-variant
rs728011 -- 10,401,019(-) tttga(A/C)tactt intron-variant
rs1154832 -- 10,406,882(-) GCAGG(C/G)CTCCT intron-variant
rs1351111 -- 10,402,849(+) ATATT(C/T)ACACG intron-variant
rs2246809 -- 10,404,445(+) ACAGT(A/G)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRC4-KLRK1 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv832328 CNV Gain 17160897
nsv898759 CNV Loss 21882294
dgv1370n71 CNV Loss 21882294
nsv898763 CNV Loss 21882294
nsv8914 CNV Loss 18304495
dgv1371n71 CNV Loss 21882294
nsv606 CNV Loss 18451855
nsv898767 CNV Loss 21882294
nsv521062 CNV Gain 19592680
esv4003 CNV Deletion 18987735

Relevant External Links for KLRC4-KLRK1 Gene

HapMap Linkage Disequilibrium report
KLRC4-KLRK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC4-KLRK1 Gene

Disorders for KLRC4-KLRK1 Gene

No disorders were found for KLRC4-KLRK1 Gene.

No data available for UniProtKB/Swiss-Prot for KLRC4-KLRK1 Gene

Publications for KLRC4-KLRK1 Gene

  1. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PMID: 2007850) Houchins J.P. … Bach F.H. (J. Exp. Med. 1991) 3
  2. A multigene family on human chromosome 12 encodes natural killer-cell lectins. (PMID: 8436421) Yabe T. … Houchins J.P. (Immunogenetics 1993) 3
  3. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B. … Trowsdale J. (Genomics 1998) 3
  4. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PMID: 9683661) Glienke J. … Francis F. (Immunogenetics 1998) 3
  5. Linkage of the NKG2 and CD94 receptor genes to D12S77 in the human natural killer gene complex. (PMID: 9887346) Sobanov Y. … Hofer E. (Immunogenetics 1999) 3

Products for KLRC4-KLRK1 Gene

Sources for KLRC4-KLRK1 Gene

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