KLRC4-KLRK1 Gene
protein-coding GIFtS: 14
GCID: GC12U901579
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KLRC4-KLRK1
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Aliases
for KLRC4-KLRK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Killer Cell Lectin-Like Receptor Subfamily K Member 12 | | KLRC4-KLRK1 Readthrough2 | | NK Cell Receptor D2 | | NKG2-D Type II Integral Membrane Protein2 | | NKG2-D-Activating NK Receptor2 |
Export aliases for KLRC4-KLRK1 gene to outside databases |
Summaries
for KLRC4-KLRK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for KLRC4-KLRK1:
This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer celllectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) geneson chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of theKLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. (provided by RefSeq, Dec2010)
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Genomic Views
for KLRC4-KLRK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KLRC4-KLRK1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLRC4-KLRK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRC4-KLRK1 |
Genomic Location:
Chromosome:12
Entrez Gene cytogenetic band: 12p GeneLoc information about chromosome 12 |
Proteins
for KLRC4-KLRK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
KLRC4-KLRK1 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001186734.1
Human Recombinant Protein Products for KLRC4-KLRK1:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
KLRC4-KLRK1 for ontologies About GeneDecksing
Antibody Products for KLRC4-KLRK1:
Assay Products for KLRC4-KLRK1: |
Protein
Domains /
Families
for KLRC4-KLRK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for KLRC4-KLRK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
KLRC4-KLRK1 for ontologies About GeneDecksing
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for KLRC4-KLRK1 | |  | Search LifeMap BioReagents cell lines for KLRC4-KLRK1 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC4-KLRK1 |
Pathways & Interactions
for KLRC4-KLRK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLRC4-KLRK1
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
KLRC4-KLRK1 for ontologies About GeneDecksing
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Drugs & Compounds
for KLRC4-KLRK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for KLRC4-KLRK1
Search CenterWatch for drugs/clinical trials and news about KLRC4-KLRK1 
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Transcripts
for KLRC4-KLRK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for KLRC4-KLRK1 gene: NM_001199805.1
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Expression
for KLRC4-KLRK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for KLRC4-KLRK1
SABiosciences Custom PCR Arrays for KLRC4-KLRK1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat KLRC4-KLRK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRC4-KLRK1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRC4-KLRK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC4-KLRK1 |
Orthologs
for KLRC4-KLRK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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Paralogs
for KLRC4-KLRK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLRC4-KLRK1 gene
- KLRK1
KLRC4-KLRK1 for paralogs About GeneDecksing
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Genomic Variants
for KLRC4-KLRK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLRC4-KLRK1: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for KLRC4-KLRK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for KLRC4-KLRK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for KLRC4-KLRK1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with KLRC4-KLRK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
- Tumor-associated MICA is shed by ADAM proteases. (PubMed id 18676862)1 Waldhauer I....Steinle A. (2008)
- Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. (PubMed id 16444266)1 Chan C.W....Housseau F. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PubMed id 15240696)1 Bacon L.... Trowsdale J. (2004)
- Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. (PubMed id 12679019)1 McFarland B.J.... Strong R.K. (2003)
- Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PubMed id 11751968)1 Shum B.P.... Parham P. (2002)
- Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? (PubMed id 11973127)1 Vivier E.... Paul P. (2002)
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External Searches for KLRC4-KLRK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KLRC4-KLRK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing KLRC4-KLRK1 gene
(According to HUGE)
About This Section
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Specialized Databases showing KLRC4-KLRK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for KLRC4-KLRK1 gene:
Search GeneIP for patents involving KLRC4-KLRK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KLRC4-KLRK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLRC4-KLRK1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRC4-KLRK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRC4-KLRK1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRC4-KLRK1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRC4-KLRK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRC4-KLRK1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC4-KLRK1 |
|  |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KLRC4-KLRK1 |
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