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Aliases for KLRC4-KLRK1 Gene

Aliases for KLRC4-KLRK1 Gene

  • KLRC4-KLRK1 Readthrough 2 3 5

External Ids for KLRC4-KLRK1 Gene

Previous GeneCards Identifiers for KLRC4-KLRK1 Gene

  • GC12U901579
  • GC12M010526
  • GC12M010618

Summaries for KLRC4-KLRK1 Gene

Entrez Gene Summary for KLRC4-KLRK1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]

GeneCards Summary for KLRC4-KLRK1 Gene

KLRC4-KLRK1 (KLRC4-KLRK1 Readthrough) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is KLRC4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC4-KLRK1 Gene

Genomics for KLRC4-KLRK1 Gene

Regulatory Elements for KLRC4-KLRK1 Gene

Enhancers for KLRC4-KLRK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F010303 0.9 FANTOM5 ENCODE 21.3 +105.1 105085 3.5 ZNF146 BHLHE40 STAT3 JUNB FOS EP300 KLF8 KLRD1 KLRC4-KLRK1 KLRF1 KLRC3 KLRK1 KLRC4 ENSG00000255958 GABARAPL1 KLRC1 KLRC2
GH12F010384 1.4 FANTOM5 Ensembl ENCODE 13.3 +22.7 22708 5.1 TBP PKNOX1 FEZF1 BMI1 ZEB1 GTF3C2 CBX5 ETV6 FOS CREM KLRA1P MAGOHB TAS2R43 KLRC3 DDX12P TAS2R14 LOC101928100 KLRC4 TAS2R20 KLRC4-KLRK1
GH12F010435 0.9 Ensembl ENCODE 11.9 -25.7 -25677 0.9 TBP STAT1 MAX IRF3 EP300 RFX5 OSR2 FOXK2 ZBTB48 TCF7L2 KLRC4 KLRC4-KLRK1 STYK1 KLRK1 KLRC3 ENSG00000255641
GH12F010391 1.6 FANTOM5 Ensembl ENCODE 6.5 +15.4 15363 7.4 ARID4B FEZF1 CBX5 DEK JUNB TSHZ1 TBX21 KAT8 ETV4 RCOR2 KLRK1 KLRC3 KLRC4 KLRC2 LOC101928100 KLRC1 KLRD1 KLRC4-KLRK1
GH12F010557 1.2 FANTOM5 Ensembl ENCODE 8 -148.4 -148376 2.9 TBL1XR1 MTA2 CBX5 ZBED1 JUNB EBF1 RELA KLRK1 KLRC4 KLRC1 KLRD1 KLRC4-KLRK1 KLRA1P LOC101060038 KLRC3 KLRC2 LOC105376675
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLRC4-KLRK1 on UCSC Golden Path with GeneCards custom track

Promoters for KLRC4-KLRK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001774907 1045 600 STAT1 CHAMP1

Genomic Location for KLRC4-KLRK1 Gene

Chromosome:
12
Start:
10,372,353 bp from pter
End:
10,410,146 bp from pter
Size:
37,794 bases
Orientation:
Minus strand

Genomic View for KLRC4-KLRK1 Gene

Genes around KLRC4-KLRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC4-KLRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC4-KLRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC4-KLRK1 Gene

Proteins for KLRC4-KLRK1 Gene

  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BQV0
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    H3BQV0

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    150 amino acids
    Molecular mass:
    17279 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BRK7
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    H3BRK7

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    37 amino acids
    Molecular mass:
    4700 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BU71
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    H3BU71

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    75 amino acids
    Molecular mass:
    8976 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    K7EPB6
    Recommended name:
    Protein KLRC4-KLRK1
    Protein Accession:
    K7EPB6

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    35 amino acids
    Molecular mass:
    4367 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLRC4-KLRK1 Gene

Post-translational modifications for KLRC4-KLRK1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KLRC4-KLRK1 Gene

Domains & Families for KLRC4-KLRK1 Gene

Protein Domains for KLRC4-KLRK1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRC4-KLRK1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KLRC4-KLRK1 Gene

Function for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Molecular Function for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 2007850
GO:0005515 protein binding IPI 10426993
GO:0030246 carbohydrate binding IEA --
GO:0032394 MHC class Ib receptor activity IEA --
GO:0042288 MHC class I protein binding IEA --
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

Phenotypes for KLRC4-KLRK1 Gene

genes like me logo Genes that share phenotypes with KLRC4-KLRK1: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLRC4-KLRK1 Gene

Localization for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Cellular Components for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2007850
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 10426994
GO:0016021 integral component of membrane IEA,TAS 9683661
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KLRC4-KLRK1 Gene

Pathways & Interactions for KLRC4-KLRK1 Gene

genes like me logo Genes that share pathways with KLRC4-KLRK1: view

Pathways by source for KLRC4-KLRK1 Gene

Interacting Proteins for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Biological Process for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway IEA --
GO:0002250 adaptive immune response IEA --
GO:0007165 signal transduction TAS 2007850
GO:0030101 natural killer cell activation TAS 18676862
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

No data available for SIGNOR curated interactions for KLRC4-KLRK1 Gene

Transcripts for KLRC4-KLRK1 Gene

mRNA/cDNA for KLRC4-KLRK1 Gene

(1) REFSEQ mRNAs :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC4-KLRK1 Gene

No ASD Table

Relevant External Links for KLRC4-KLRK1 Gene

GeneLoc Exon Structure for
KLRC4-KLRK1
ECgene alternative splicing isoforms for
KLRC4-KLRK1

Expression for KLRC4-KLRK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLRC4-KLRK1 Gene

mRNA differential expression in normal tissues according to GTEx for KLRC4-KLRK1 Gene

This gene is overexpressed in Whole Blood (x5.4) and Spleen (x5.3).
genes like me logo Genes that share expression patterns with KLRC4-KLRK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KLRC4-KLRK1 Gene

Orthologs for KLRC4-KLRK1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC4-KLRK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRC4 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 38 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia KLRC1 35
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Klri2 35
  • 12 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 5 (a)
OneToMany
Species where no ortholog for KLRC4-KLRK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC4-KLRK1 Gene

ENSEMBL:
Gene Tree for KLRC4-KLRK1 (if available)
TreeFam:
Gene Tree for KLRC4-KLRK1 (if available)

Paralogs for KLRC4-KLRK1 Gene

Paralogs for KLRC4-KLRK1 Gene

(5) SIMAP similar genes for KLRC4-KLRK1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KLRC4-KLRK1: view

Variants for KLRC4-KLRK1 Gene

Sequence variations from dbSNP and Humsavar for KLRC4-KLRK1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1049172 -- 10,373,141(-) AATAC(A/G)TACAT intron-variant, reference, synonymous-codon
rs1049174 -- 10,372,766(-) GATCA(C/G)TGAGA intron-variant, utr-variant-3-prime
rs10537864 -- 10,373,696(+) TATAA(-/GT)GTGTG intron-variant
rs10537865 -- 10,373,750(+) TTCTA(-/TATC)TATAT intron-variant
rs10540330 -- 10,379,235(+) AAAAA(-/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRC4-KLRK1 Gene

Variant ID Type Subtype PubMed ID
dgv2358n54 CNV loss 21841781
esv3892136 CNV loss 25118596
esv4003 CNV loss 18987735
nsv1036390 CNV loss 25217958
nsv1051292 CNV loss 25217958
nsv521062 CNV gain 19592680
nsv557455 CNV loss 21841781
nsv606 CNV deletion 18451855
nsv832328 CNV gain 17160897
nsv8914 CNV loss 18304495

Variation tolerance for KLRC4-KLRK1 Gene

Gene Damage Index Score: 0.04; 0.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLRC4-KLRK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLRC4-KLRK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC4-KLRK1 Gene

Disorders for KLRC4-KLRK1 Gene

Relevant External Links for KLRC4-KLRK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLRC4-KLRK1

No disorders were found for KLRC4-KLRK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRC4-KLRK1 Gene

Publications for KLRC4-KLRK1 Gene

  1. Genome-wide association analysis identifies new susceptibility loci for BehAset's disease and epistasis between HLA-B*51 and ERAP1. (PMID: 23291587) Kirino Y. … Kastner D.L. (Nat. Genet. 2013) 3 64
  2. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. (PMID: 23696226) Hosomi S. … Blumberg R.S. (Eur. J. Immunol. 2013) 3 64
  3. Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. (PMID: 22585739) Serrano-Pertierra E. … LA^pez-Larrea C. (Eur. J. Immunol. 2012) 3 64
  4. A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans. (PMID: 21712812) Tsuboi S. … Ohyama C. (EMBO J. 2011) 3 64
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for KLRC4-KLRK1 Gene

Sources for KLRC4-KLRK1 Gene

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