KLRC4 Gene
protein-coding GIFtS: 54
GCID: GC12M010559
|
|
killer cell lectin-like receptor subfamily C, member 4
| |
Aliases
for KLRC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Killer Cell Lectin-Like Receptor Subfamily C, Member 41 2 | | NKG2-F-Activating NK Receptor2 3 | | NKG2F2 3 5 | | Natual Killer Cell Group 2-F2 | | NKG2-F1 2 | | NKG2-F Type II Integral Membrane Protein2 | | NK Cell Receptor F2 3 | | D12S2489E5 |
Export aliases for KLRC4 gene to outside databasesPrevious GC identifers: GC12M010207 GC12M010648 GC12M010426 GC12M010451 GC12M010417 GC12M010418 GC12M010303 |
Summaries
for KLRC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLRC4:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cellswithout previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cellspreferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NKcell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK)cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation(have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located withinthe NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-throughtranscription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member1) family member. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: NKG2F_HUMAN, O43908Function: May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells
Gene Wiki entry for KLRC4
|
Genomic Views
for KLRC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLRC4 gene promoter:
c-Fos AP-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLRC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.2-p12.3 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.2-p12.3KLRC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010559: view genomic region
(about GC identifiers)
Start:
|
10,559,983 bp from pter |
End:
|
10,562,356 bp from pter |
Size:
|
2,374 bases |
Orientation:
|
minus strand |
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Proteins
for KLRC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NKG2F_HUMAN, O43908 (See
protein sequence)Recommended Name: NKG2-F type II integral membrane protein Size: 158 amino acids; 18234 Da
Subunit: Can form disulfide-bonded heterodimer with CD94
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: O60851Explore the universe of human proteins at neXtProt for KLRC4: NX_O43908
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43908
KLRC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_038459.1
ENSEMBL proteins: ENSP00000310216
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
KLRC4 for ontologies About GeneDecksing
KLRC4 Antibody Products:
Assay Products for KLRC4: |
Protein
Domains /
Families
for KLRC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLRC4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43908ProtoNet protein and cluster: O43908 |
Function
for KLRC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NKG2F_HUMAN, O43908Function: May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells Genatlas biochemistry entry for KLRC4:natural killer cell lectin-like receptor subfamily C,member 4,expressed on NK cells,complexing with KAP10 to form anactivating complex receptor for MICA
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRC4
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
KLRC4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KLRC4:
|
Pathways & Interactions
for KLRC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Allograft rejection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for KLRC4):
KLRC4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLRC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for KLRC4 (O439083 ENSP000003102164) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006968 | cellular defense response |
TAS | 9683661 |
KLRC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLRC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLRC4
Search CenterWatch for drugs/clinical trials and news about KLRC4 / NKG2F
|
Transcripts
for KLRC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLRC4 gene: NM_013431.2 Unigene Cluster for KLRC4: Killer cell lectin-like receptor subfamily C, member 4 Hs.721094 [show with all ESTs]Unigene Representative Sequence: FY2119491 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000309384(uc001qye.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLRC4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLRC4 (NM_013431) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLRC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC4 |
Additional cDNA sequence: AF350018.1 AF350019.1 AJ001683.1 BC017784.1 U96845.1 2 DOTS entries: DT.108632 DT.91722276 24/84 AceView cDNA sequences (see all 84): CB216677 AA361092 CR597595 BC017784 AF260135 CR607215 AF439512 BM456777 CB241686 AA766117 BE208303 BQ708055 AA292938 AF260136 BQ005357 BM740579 BX099329 BC039836 U96845 BG682117 BE543391 BE301422 BG485675 BX489639
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KLRC4 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | | | - | | - | | | | - | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLRC4
|
Expression
for KLRC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLRC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCTATAAA
About this image
See KLRC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLRC4
SOURCE GeneReport for Unigene cluster: Hs.721094
UniProtKB/Swiss-Prot: NKG2F_HUMAN, O43908Tissue specificity: Natural killer cells
SABiosciences Custom PCR Arrays for KLRC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLRC4
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for KLRC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLRC4 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CLEC9A6 |
-- |
17(a) |
1 → many |
2(81818136-81823316) |
ENSEMBL Gene Tree for KLRC4 (if available)
TreeFam Gene Tree for KLRC4 (if available) |
Paralogs
for KLRC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLRC4 gene
- OLR12 CLEC9A2 KLRC22 ENSG000002558192 CLEC12A2 CLEC1A2 KLRC32 KLRD12
- KLRK12 CLEC1B2 ENSG000002556412 CLEC7A2 KLRC12 CLEC12B2
4 SIMAP similar genes for KLRC4 using alignment to 1 protein entry: NKG2F_HUMAN:KLRK1 KLRC2 KLRC3 KLRC1
KLRC4 for paralogs About GeneDecksing
|
Genomic Variants
for KLRC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLRC4 (10559983 - 10562356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLRC4
1 CNV: 35036 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRC4 |
|
Disorders
/ Diseases
for KLRC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLRC4 for disorders About GeneDecksing
OMIM gene information: 602893
OMIM disorders: --
3  diseases for KLRC4: About MalaCardshepatitis b nasopharyngitis hepatitis
1 disease from the University of Copenhagen DISEASES database for KLRC4:Nasopharyngitis Human Genome Epidemiology (HuGE) Navigator: KLRC4 (7 documents)
Export disorders for KLRC4 gene to outside databases
|
Publications
for KLRC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLRC4 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with KLRC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PubMed id 9598306)1, 2, 3, 9 Plougastel B. and Trowsdale J. (1998)
- Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. (PubMed id 9394807)1, 2, 9 Plougastel B. and Trowsdale J. (1997)
- Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PubMed id 11751968)1, 2, 9 Shum B.P.... Parham P. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PubMed id 9683661)1, 2 Glienke J.... Francis F. (1998)
- Linkage of the NKG2 and CD94 receptor genes to D12S77 in the human natural killer gene complex. (PubMed id 9887346)1, 9 Sobanov Y....Hofer E. (1999)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Association of NKG2D genetic polymorphism with suscep tibility to chronic hepatitis B in a Han Chinese population. (PubMed id 20648603)1 Ma J....Liu Y. (2010)
- Up-regulation of NKG2F receptor, a functionally unkno wn killer receptor, of human natural killer cells by interleukin-2 and interleu kin-15. (PubMed id 20811687)1 Huang H....Sun R. (2010)
- [Study on expression of natural killer (NK) cell C-ty pe lectin-like receptors in nasal NK/T-cell lymphomas]. (PubMed id 20654155)1 Nong L....Li T. (2010)
|
External Searches for KLRC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLRC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLRC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLRC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KLRC4 gene:
Search GeneIP for patents involving KLRC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLRC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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