Aliases for KLRC4 Gene
External Ids for KLRC4 Gene
Previous GeneCards Identifiers for KLRC4 Gene
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]
GeneCards Summary for KLRC4 Gene
KLRC4 (Killer Cell Lectin Like Receptor C4) is a Protein Coding gene. Diseases associated with KLRC4 include behcet's disease. Among its related pathways are Allograft rejection. An important paralog of this gene is KLRC1.
UniProtKB/Swiss-Prot for KLRC4 Gene
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.