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Aliases for KLRC4 Gene

Aliases for KLRC4 Gene

  • Killer Cell Lectin Like Receptor C4 2 3
  • Killer Cell Lectin-Like Receptor Subfamily C, Member 4 2 3 5
  • NKG2-F-Activating NK Receptor 3 4
  • NK Cell Receptor F 3 4
  • NKG2F 3 4
  • Natual Killer Cell Group 2-F 3
  • NKG2-F 3

External Ids for KLRC4 Gene

Previous GeneCards Identifiers for KLRC4 Gene

  • GC12M010207
  • GC12M010648
  • GC12M010426
  • GC12M010451
  • GC12M010417
  • GC12M010418
  • GC12M010559
  • GC12M010303
  • GC12M010713

Summaries for KLRC4 Gene

Entrez Gene Summary for KLRC4 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]

GeneCards Summary for KLRC4 Gene

KLRC4 (Killer Cell Lectin Like Receptor C4) is a Protein Coding gene. Diseases associated with KLRC4 include Behcet's Disease. Among its related pathways are Allograft rejection. An important paralog of this gene is KLRC1.

UniProtKB/Swiss-Prot for KLRC4 Gene

  • May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.

Gene Wiki entry for KLRC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC4 Gene

Genomics for KLRC4 Gene

Regulatory Elements for KLRC4 Gene

Enhancers for KLRC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLRC4 on UCSC Golden Path with GeneCards custom track

Promoters for KLRC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLRC4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KLRC4 gene promoter:

Genomic Location for KLRC4 Gene

Chromosome:
12
Start:
10,407,382 bp from pter
End:
10,409,757 bp from pter
Size:
2,376 bases
Orientation:
Minus strand

Genomic View for KLRC4 Gene

Genes around KLRC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC4 Gene

Proteins for KLRC4 Gene

  • Protein details for KLRC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43908-NKG2F_HUMAN
    Recommended name:
    NKG2-F type II integral membrane protein
    Protein Accession:
    O43908
    Secondary Accessions:
    • O60851

    Protein attributes for KLRC4 Gene

    Size:
    158 amino acids
    Molecular mass:
    18234 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94.

neXtProt entry for KLRC4 Gene

Proteomics data for KLRC4 Gene at MOPED

Post-translational modifications for KLRC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLRC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KLRC4

No data available for DME Specific Peptides for KLRC4 Gene

Domains & Families for KLRC4 Gene

Gene Families for KLRC4 Gene

Protein Domains for KLRC4 Gene

Suggested Antigen Peptide Sequences for KLRC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRC4: view

No data available for UniProtKB/Swiss-Prot for KLRC4 Gene

Function for KLRC4 Gene

Molecular function for KLRC4 Gene

GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily C,member 4,expressed on NK cells,complexing with KAP10 to form an activating complex receptor for MICA
UniProtKB/Swiss-Prot Function:
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
genes like me logo Genes that share phenotypes with KLRC4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC4 Gene

Localization for KLRC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLRC4 Gene COMPARTMENTS Subcellular localization image for KLRC4 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for KLRC4 Gene

Pathways & Interactions for KLRC4 Gene

SuperPathways for KLRC4 Gene

Superpath Contained pathways
1 Allograft rejection
genes like me logo Genes that share pathways with KLRC4: view

Pathways by source for KLRC4 Gene

1 KEGG pathway for KLRC4 Gene

Gene Ontology (GO) - Biological Process for KLRC4 Gene

None

No data available for SIGNOR curated interactions for KLRC4 Gene

Drugs & Compounds for KLRC4 Gene

No Compound Related Data Available

Transcripts for KLRC4 Gene

mRNA/cDNA for KLRC4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLRC4 Gene

Killer cell lectin-like receptor subfamily C, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for KLRC4 Gene

GeneLoc Exon Structure for
KLRC4
ECgene alternative splicing isoforms for
KLRC4

Expression for KLRC4 Gene

mRNA expression in normal human tissues for KLRC4 Gene

Protein differential expression in normal tissues from HIPED for KLRC4 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLRC4 Gene



SOURCE GeneReport for Unigene cluster for KLRC4 Gene Hs.721094

mRNA Expression by UniProt/SwissProt for KLRC4 Gene

O43908-NKG2F_HUMAN
Tissue specificity: Natural killer cells.
genes like me logo Genes that share expression patterns with KLRC4: view

Protein tissue co-expression partners for KLRC4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KLRC4 Gene

Orthologs for KLRC4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NKG2A 36
  • 31 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Klrc3 36
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 5 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KLRC4 36
  • 96 (a)
OneToOne
Species with no ortholog for KLRC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC4 Gene

ENSEMBL:
Gene Tree for KLRC4 (if available)
TreeFam:
Gene Tree for KLRC4 (if available)

Paralogs for KLRC4 Gene

Paralogs for KLRC4 Gene

(4) SIMAP similar genes for KLRC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLRC4: view

Variants for KLRC4 Gene

Sequence variations from dbSNP and Humsavar for KLRC4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_013406 -
VAR_013407 -

Structural Variations from Database of Genomic Variants (DGV) for KLRC4 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv832328 CNV Gain 17160897
nsv898759 CNV Loss 21882294
dgv1370n71 CNV Loss 21882294
nsv898763 CNV Loss 21882294
nsv8914 CNV Loss 18304495
dgv1371n71 CNV Loss 21882294
nsv606 CNV Loss 18451855
nsv898767 CNV Loss 21882294
nsv521062 CNV Gain 19592680

Variation tolerance for KLRC4 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLRC4 Gene

Disorders for KLRC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLRC4 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
behcet's disease
  • adamantiades-behcet disease
- elite association - COSMIC cancer census association via MalaCards
Search KLRC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLRC4

Genetic Association Database (GAD)
KLRC4
Human Genome Epidemiology (HuGE) Navigator
KLRC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLRC4
genes like me logo Genes that share disorders with KLRC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLRC4 Gene

Publications for KLRC4 Gene

  1. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B. … Trowsdale J. (Genomics 1998) 2 3 4 23 67
  2. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PMID: 11751968) Shum B.P. … Parham P. (J. Immunol. 2002) 3 23
  3. Linkage of the NKG2 and CD94 receptor genes to D12S77 in the human natural killer gene complex. (PMID: 9887346) Sobanov Y. … Hofer E. (Immunogenetics 1999) 3 23
  4. Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. (PMID: 9394807) Plougastel B. … Trowsdale J. (Eur. J. Immunol. 1997) 3 23
  5. Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 With BehAset's disease in Iranians. (PMID: 26097239) Sousa I. … Oliveira S.A. ( 2015) 3

Products for KLRC4 Gene

Sources for KLRC4 Gene

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