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Aliases for KLRC4 Gene

Aliases for KLRC4 Gene

  • Killer Cell Lectin Like Receptor C4 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily C, Member 4 2 3
  • NKG2-F-Activating NK Receptor 3 4
  • NK Cell Receptor F 3 4
  • NKG2F 3 4
  • NKG2-F Type II Integral Membrane Protein 3
  • Natual Killer Cell Group 2-F 3
  • NKG2-F 3

External Ids for KLRC4 Gene

Previous GeneCards Identifiers for KLRC4 Gene

  • GC12M010207
  • GC12M010648
  • GC12M010426
  • GC12M010451
  • GC12M010417
  • GC12M010418
  • GC12M010559
  • GC12M010303
  • GC12M010713
  • GC12M010779
  • GC12M011015

Summaries for KLRC4 Gene

Entrez Gene Summary for KLRC4 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]

GeneCards Summary for KLRC4 Gene

KLRC4 (Killer Cell Lectin Like Receptor C4) is a Protein Coding gene. Diseases associated with KLRC4 include Behcet Syndrome. Among its related pathways are Allograft rejection. An important paralog of this gene is KLRC4-KLRK1.

UniProtKB/Swiss-Prot for KLRC4 Gene

  • May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.

Gene Wiki entry for KLRC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC4 Gene

Genomics for KLRC4 Gene

Regulatory Elements for KLRC4 Gene

Enhancers for KLRC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F010391 1.6 FANTOM5 Ensembl ENCODE 17.2 +15.0 14974 7.4 ARID4B FEZF1 CBX5 DEK JUNB TSHZ1 TBX21 KAT8 ETV4 RCOR2 KLRK1 KLRC3 KLRC4 KLRC2 LOC101928100 KLRC1 KLRD1 KLRC4-KLRK1
GH12F010557 1.2 FANTOM5 Ensembl ENCODE 19.6 -148.8 -148765 2.9 TBL1XR1 MTA2 CBX5 ZBED1 JUNB EBF1 RELA KLRK1 KLRC4 KLRC1 KLRD1 KLRC4-KLRK1 KLRA1P LOC101060038 KLRC3 KLRC2 LOC105376675
GH12F010553 1.2 FANTOM5 Ensembl ENCODE 17.9 -145.1 -145093 2.5 SMAD5 CBX5 ZBED1 EED CBFB KLRK1 KLRC4 KLRC1 KLRD1 LOC101060038 KLRA1P KLRC4-KLRK1 KLRC3 KLRC2 LOC105376675
GH12F010384 1.4 FANTOM5 Ensembl ENCODE 14.3 +22.3 22319 5.1 TBP PKNOX1 FEZF1 BMI1 ZEB1 GTF3C2 CBX5 ETV6 FOS CREM KLRA1P MAGOHB TAS2R43 KLRC3 DDX12P TAS2R14 LOC101928100 KLRC4 TAS2R20 KLRC4-KLRK1
GH12F010369 0.8 FANTOM5 Ensembl ENCODE 16.1 +39.7 39686 1.2 KLRK1 KLRC4 KLRC2 KLRD1 STYK1 KLRC1 KLRC4-KLRK1 KLRC3 LOC101928100 GC12P010386
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLRC4 on UCSC Golden Path with GeneCards custom track

Promoters for KLRC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001774907 656 600 STAT1 CHAMP1

Genomic Location for KLRC4 Gene

10,407,382 bp from pter
10,409,757 bp from pter
2,376 bases
Minus strand

Genomic View for KLRC4 Gene

Genes around KLRC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC4 Gene

Proteins for KLRC4 Gene

  • Protein details for KLRC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NKG2-F type II integral membrane protein
    Protein Accession:
    Secondary Accessions:
    • O60851

    Protein attributes for KLRC4 Gene

    158 amino acids
    Molecular mass:
    18234 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94.

neXtProt entry for KLRC4 Gene

Post-translational modifications for KLRC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLRC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRC4 Gene

Domains & Families for KLRC4 Gene

Gene Families for KLRC4 Gene

Protein Domains for KLRC4 Gene

Suggested Antigen Peptide Sequences for KLRC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRC4: view

No data available for UniProtKB/Swiss-Prot for KLRC4 Gene

Function for KLRC4 Gene

Molecular function for KLRC4 Gene

GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily C,member 4,expressed on NK cells,complexing with KAP10 to form an activating complex receptor for MICA
UniProtKB/Swiss-Prot Function:
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
genes like me logo Genes that share phenotypes with KLRC4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC4 Gene

Localization for KLRC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRC4 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLRC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRC4: view

Pathways & Interactions for KLRC4 Gene

SuperPathways for KLRC4 Gene

SuperPathway Contained pathways
1 Allograft rejection
genes like me logo Genes that share pathways with KLRC4: view

Pathways by source for KLRC4 Gene

1 KEGG pathway for KLRC4 Gene

Gene Ontology (GO) - Biological Process for KLRC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9683661
genes like me logo Genes that share ontologies with KLRC4: view

No data available for SIGNOR curated interactions for KLRC4 Gene

Transcripts for KLRC4 Gene

mRNA/cDNA for KLRC4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLRC4 Gene

Killer cell lectin-like receptor subfamily C, member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for KLRC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLRC4 Gene

Protein differential expression in normal tissues from HIPED for KLRC4 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLRC4 Gene

Protein tissue co-expression partners for KLRC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLRC4 Gene:


SOURCE GeneReport for Unigene cluster for KLRC4 Gene:


mRNA Expression by UniProt/SwissProt for KLRC4 Gene:

Tissue specificity: Natural killer cells.
genes like me logo Genes that share expression patterns with KLRC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KLRC4 Gene

Orthologs for KLRC4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRC4 35
  • 96 (a)
(Bos Taurus)
Mammalia NKG2A 35
  • 31 (a)
(Canis familiaris)
Mammalia -- 35
  • 29 (a)
(Mus musculus)
Mammalia Klrc3 35
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 5 (a)
Species where no ortholog for KLRC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC4 Gene

Gene Tree for KLRC4 (if available)
Gene Tree for KLRC4 (if available)

Paralogs for KLRC4 Gene

Paralogs for KLRC4 Gene

(4) SIMAP similar genes for KLRC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLRC4: view

Variants for KLRC4 Gene

Sequence variations from dbSNP and Humsavar for KLRC4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10772275 -- 10,410,993(+) AGTAT(C/T)ATTAC upstream-variant-2KB
rs11053787 -- 10,407,315(+) AACTT(C/T)TATTT intron-variant, downstream-variant-500B
rs112330004 -- 10,411,573(+) AGCGA(G/T)ACTCT upstream-variant-2KB
rs112429327 -- 10,408,345(+) CTTCT(A/T)TTCAG reference, missense, utr-variant-5-prime
rs112949739 -- 10,408,758(+) ATTTA(C/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRC4 Gene

Variant ID Type Subtype PubMed ID
nsv8914 CNV loss 18304495
nsv832328 CNV gain 17160897
nsv606 CNV deletion 18451855
nsv557455 CNV loss 21841781
nsv521062 CNV gain 19592680
nsv1051292 CNV loss 25217958
nsv1036390 CNV loss 25217958
esv3892136 CNV loss 25118596
dgv2358n54 CNV loss 21841781

Variation tolerance for KLRC4 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLRC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC4 Gene

Disorders for KLRC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLRC4 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
behcet syndrome
  • behcet's disease
- elite association - COSMIC cancer census association via MalaCards
Search KLRC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLRC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KLRC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLRC4 Gene

Publications for KLRC4 Gene

  1. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B. … Trowsdale J. (Genomics 1998) 2 3 4 22 64
  2. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PMID: 11751968) Shum B.P. … Parham P. (J. Immunol. 2002) 3 4 22 64
  3. Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. (PMID: 9394807) Plougastel B. … Trowsdale J. (Eur. J. Immunol. 1997) 3 4 22 64
  4. Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population. (PMID: 20648603) Ma J. … Liu Y. (J. Med. Virol. 2010) 3 46 64
  5. Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis. (PMID: 18006695) Sellick G.S. … Houlston R.S. (Blood 2008) 3 46 64

Products for KLRC4 Gene

Sources for KLRC4 Gene

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