Aliases for KLRC4 Gene
External Ids for KLRC4 Gene
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]
GeneCards Summary for KLRC4 Gene
KLRC4 (Killer Cell Lectin-Like Receptor Subfamily C, Member 4) is a Protein Coding gene. Diseases associated with KLRC4 include nasopharyngitis. Among its related pathways are Allograft rejection. An important paralog of this gene is KLRC1.
UniProtKB/Swiss-Prot for KLRC4 Gene
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells