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Aliases for KLRC3 Gene

Aliases for KLRC3 Gene

  • Killer Cell Lectin-Like Receptor Subfamily C, Member 3 2 3
  • NKG2E 3 4 6
  • NKG2-E-Activating NK Receptor 3 4
  • NK Cell Receptor E 3 4
  • NKG2-E Type II Integral Membrane Protein 3
  • NKG2-E 3

External Ids for KLRC3 Gene

Previous GeneCards Identifiers for KLRC3 Gene

  • GC12U990043
  • GC12M010687
  • GC12M010465
  • GC12M010564
  • GC12M010307

Summaries for KLRC3 Gene

Entrez Gene Summary for KLRC3 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRC3 Gene

KLRC3 (Killer Cell Lectin-Like Receptor Subfamily C, Member 3) is a Protein Coding gene. Diseases associated with KLRC3 include monkeypox. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is KLRC1.

UniProtKB/Swiss-Prot for KLRC3 Gene

  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC3 Gene

Genomics for KLRC3 Gene

Regulatory Elements for KLRC3 Gene

Genomic Location for KLRC3 Gene

Start:
10,412,312 bp from pter
End:
10,420,595 bp from pter
Size:
8,284 bases
Orientation:
Minus strand

Genomic View for KLRC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC3 Gene

Proteins for KLRC3 Gene

  • Protein details for KLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07444-NKG2E_HUMAN
    Recommended name:
    NKG2-E type II integral membrane protein
    Protein Accession:
    Q07444
    Secondary Accessions:
    • Q8WXA4
    • Q96RL0
    • Q9UP04

    Protein attributes for KLRC3 Gene

    Size:
    240 amino acids
    Molecular mass:
    27100 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94

    Alternative splice isoforms for KLRC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLRC3 Gene

Proteomics data for KLRC3 Gene at MOPED

Post-translational modifications for KLRC3 Gene

  • Glycosylation at Asn100, Asn149, and Asn179
  • Modification sites at PhosphoSitePlus

Other Protein References for KLRC3 Gene

No data available for DME Specific Peptides for KLRC3 Gene

Domains for KLRC3 Gene

Gene Families for KLRC3 Gene

HGNC:
  • KLR :Killer cell lectin-like receptors

Protein Domains for KLRC3 Gene

Suggested Antigen Peptide Sequences for KLRC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07444

UniProtKB/Swiss-Prot:

NKG2E_HUMAN :
  • Q07444
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRC3: view

Function for KLRC3 Gene

Molecular function for KLRC3 Gene

GENATLAS Biochemistry: natural killer cell lectin-like receptor subfamily C,member 3
UniProtKB/Swiss-Prot Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells

Gene Ontology (GO) - Molecular Function for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9683661
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRC3: view

Phenotypes for KLRC3 Gene

GenomeRNAi human phenotypes for KLRC3:
genes like me logo Genes that share phenotypes with KLRC3: view

miRNA for KLRC3 Gene

miRTarBase miRNAs that target KLRC3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLRC3 Gene

Localization for KLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLRC3 Gene COMPARTMENTS Subcellular localization image for KLRC3 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRC3: view

Pathways for KLRC3 Gene

genes like me logo Genes that share pathways with KLRC3: view

Pathways by source for KLRC3 Gene

1 GeneGo (Thomson Reuters) pathway for KLRC3 Gene

Interacting Proteins for KLRC3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371328%0d%0a9606.ENSP00000338130%0d%0a9606.ENSP00000262629%0d%0a
Selected Interacting proteins: ENSP00000371328 Q07444-NKG2E_HUMAN for KLRC3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9683661
GO:0007165 signal transduction TAS 9683661
genes like me logo Genes that share ontologies with KLRC3: view

Transcripts for KLRC3 Gene

Unigene Clusters for KLRC3 Gene

Killer cell lectin-like receptor subfamily C, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC3 Gene

No ASD Table

Relevant External Links for KLRC3 Gene

GeneLoc Exon Structure for
KLRC3
ECgene alternative splicing isoforms for
KLRC3

Expression for KLRC3 Gene

mRNA expression in normal human tissues for KLRC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRC3 Gene

This gene is overexpressed in Whole Blood (7.5) and Brain - Amygdala (4.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KLRC3 Gene

SOURCE GeneReport for Unigene cluster for KLRC3 Gene Hs.654362

mRNA Expression by UniProt/SwissProt for KLRC3 Gene

Q07444-NKG2E_HUMAN
Tissue specificity: Natural killer cells
genes like me logo Genes that share expressions with KLRC3: view

Orthologs for KLRC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRC3 35
  • 96.61 (n)
  • 94.69 (a)
KLRC3 36
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NKG2A 36
  • 46 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Klrc3 16
Klri1 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
OneToMany
Species with no ortholog for KLRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC3 Gene

ENSEMBL:
Gene Tree for KLRC3 (if available)
TreeFam:
Gene Tree for KLRC3 (if available)

Paralogs for KLRC3 Gene

Paralogs for KLRC3 Gene

Selected SIMAP similar genes for KLRC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLRC3: view

Variants for KLRC3 Gene

Sequence variations from dbSNP and Humsavar for KLRC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs985753 -- 10,412,471(-) TTAAA(A/G)ATCTA utr-variant-3-prime
rs995873 -- 10,412,535(-) agttg(C/G)tggga utr-variant-3-prime
rs1138437 - 10,418,425(+) GAAAG(A/T)AGAAC reference, missense
rs1545750 -- 10,412,854(+) ATATA(A/G)TTGAA intron-variant
rs1971939 -- 10,412,916(+) TGATG(C/G)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRC3 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv832328 CNV Gain 17160897
nsv898759 CNV Loss 21882294
nsv898763 CNV Loss 21882294
nsv8914 CNV Loss 18304495
dgv1371n71 CNV Loss 21882294
nsv606 CNV Loss 18451855
nsv898767 CNV Loss 21882294
nsv521062 CNV Gain 19592680
esv4003 CNV Deletion 18987735
dgv1372n71 CNV Loss 21882294
nsv898769 CNV Gain 21882294
esv25005 CNV Loss 19812545
dgv263e199 CNV Deletion 23128226
esv2745535 CNV Deletion 23290073
dgv270n67 CNV Loss 20364138
esv32543 CNV Loss 17666407
nsv435631 CNV Deletion 17901297

Relevant External Links for KLRC3 Gene

HapMap Linkage Disequilibrium report
KLRC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC3 Gene

Disorders for KLRC3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KLRC3 Gene including...

Search for KLRC3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for KLRC3 Gene

genes like me logo Genes that share disorders with KLRC3: view

No data available for UniProtKB/Swiss-Prot for KLRC3 Gene

Publications for KLRC3 Gene

  1. Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer. (PMID: 10201920) Bellon T. … Aparicio P. (J. Immunol. 1999) 3 4 23
  2. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PMID: 11751968) Shum B.P. … Parham P. (J. Immunol. 2002) 3 4 23
  3. Natural killer lectin-like receptors have divergent carboxy-termini, distinct from C-type lectins. (PMID: 8276468) Adamkiewicz T.V. … Houchins J.P. (Immunogenetics 1994) 3 4
  4. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B. … Trowsdale J. (Genomics 1998) 2 3
  5. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PMID: 9683661) Glienke J. … Francis F. (Immunogenetics 1998) 3 4

Products for KLRC3 Gene

Sources for KLRC3 Gene

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