Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLRC3 Gene

Aliases for KLRC3 Gene

  • Killer Cell Lectin Like Receptor C3 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily C, Member 3 2 3
  • NKG2-E-Activating NK Receptor 3 4
  • NK Cell Receptor E 3 4
  • NKG2E 3 4
  • NKG2-E Type II Integral Membrane Protein 3
  • NKG2-E 3

External Ids for KLRC3 Gene

Previous GeneCards Identifiers for KLRC3 Gene

  • GC12U990043
  • GC12M010687
  • GC12M010465
  • GC12M010456
  • GC12M010564
  • GC12M010307
  • GC12M010718
  • GC12M010781
  • GC12M011018

Summaries for KLRC3 Gene

Entrez Gene Summary for KLRC3 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRC3 Gene

KLRC3 (Killer Cell Lectin Like Receptor C3) is a Protein Coding gene. Among its related pathways are Allograft rejection and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is ENSG00000255641.

UniProtKB/Swiss-Prot for KLRC3 Gene

  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC3 Gene

Genomics for KLRC3 Gene

Regulatory Elements for KLRC3 Gene

Enhancers for KLRC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F010391 1.6 FANTOM5 Ensembl ENCODE 19.8 +25.8 25812 7.4 ARID4B FEZF1 CBX5 DEK JUNB TSHZ1 TBX21 KAT8 ETV4 RCOR2 KLRK1 KLRC3 KLRC4 KLRC2 LOC101928100 KLRC1 KLRD1 KLRC4-KLRK1
GH12F010303 0.9 FANTOM5 ENCODE 15.6 +115.5 115534 3.5 ZNF146 BHLHE40 STAT3 JUNB FOS EP300 KLF8 KLRD1 KLRC4-KLRK1 KLRF1 KLRC3 KLRK1 KLRC4 ENSG00000255958 GABARAPL1 KLRC1 KLRC2
GH12F010408 0.7 ENCODE 19.2 +11.2 11204 1.1 CTCF STAT1 ZNF654 TAL1 IRF3 TRIM22 JUNB REST FEZF1 RAD21 KLRC3 DDX12P LOC255308 LOC101928100 ENSG00000256682 ENSG00000213443 TAS2R43 ENSG00000256981 TAS2R50 KLRC2
GH12F010410 0.9 Ensembl ENCODE 14.3 +9.2 9209 1.1 CTCF KLF1 ZNF362 CEBPB TRIM22 RAD21 ZNF843 SCRT2 SMC3 ZNF580 KLRC3 KLRC2 KLRC4-KLRK1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLRC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLRC3 Gene

10,412,312 bp from pter
10,420,595 bp from pter
8,284 bases
Minus strand

Genomic View for KLRC3 Gene

Genes around KLRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC3 Gene

Proteins for KLRC3 Gene

  • Protein details for KLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NKG2-E type II integral membrane protein
    Protein Accession:
    Secondary Accessions:
    • Q8WXA4
    • Q96RL0
    • Q9UP04

    Protein attributes for KLRC3 Gene

    240 amino acids
    Molecular mass:
    27100 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94.

    Alternative splice isoforms for KLRC3 Gene


neXtProt entry for KLRC3 Gene

Post-translational modifications for KLRC3 Gene

  • Glycosylation at Asn 100, Asn 149, and Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for KLRC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRC3 Gene

Domains & Families for KLRC3 Gene

Protein Domains for KLRC3 Gene

Suggested Antigen Peptide Sequences for KLRC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRC3: view

Function for KLRC3 Gene

Molecular function for KLRC3 Gene

GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily C,member 3
UniProtKB/Swiss-Prot Function:
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Gene Ontology (GO) - Molecular Function for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9683661
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRC3: view
genes like me logo Genes that share phenotypes with KLRC3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC3 Gene

Localization for KLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRC3 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRC3: view

Pathways & Interactions for KLRC3 Gene

genes like me logo Genes that share pathways with KLRC3: view

Interacting Proteins for KLRC3 Gene

Gene Ontology (GO) - Biological Process for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9683661
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with KLRC3: view

No data available for SIGNOR curated interactions for KLRC3 Gene

Transcripts for KLRC3 Gene

mRNA/cDNA for KLRC3 Gene

Unigene Clusters for KLRC3 Gene

Killer cell lectin-like receptor subfamily C, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC3 Gene

No ASD Table

Relevant External Links for KLRC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLRC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRC3 Gene

This gene is overexpressed in Whole Blood (x7.5) and Brain - Amygdala (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLRC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLRC3 Gene:


SOURCE GeneReport for Unigene cluster for KLRC3 Gene:


mRNA Expression by UniProt/SwissProt for KLRC3 Gene:

Tissue specificity: Natural killer cells.
genes like me logo Genes that share expression patterns with KLRC3: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for KLRC3 Gene

Orthologs for KLRC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRC3 34 35
  • 96.61 (n)
(Canis familiaris)
Mammalia -- 35
  • 56 (a)
(Bos Taurus)
Mammalia NKG2A 35
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
(Mus musculus)
Mammalia Klri1 35
  • 23 (a)
Species where no ortholog for KLRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC3 Gene

Gene Tree for KLRC3 (if available)
Gene Tree for KLRC3 (if available)

Paralogs for KLRC3 Gene

Paralogs for KLRC3 Gene

(9) SIMAP similar genes for KLRC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLRC3: view

Variants for KLRC3 Gene

Sequence variations from dbSNP and Humsavar for KLRC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10734829 -- 10,420,612(+) TATAA(A/G)TGGTG upstream-variant-2KB
rs10734830 -- 10,420,696(+) TAACC(A/T)AGGTA upstream-variant-2KB
rs10734831 -- 10,420,698(+) ACCTA(G/T)GTAAA upstream-variant-2KB
rs10743890 -- 10,418,559(+) TAGTT(C/T)ACATA intron-variant
rs11053789 -- 10,414,621(+) ggggg(A/G)agggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRC3 Gene

Variant ID Type Subtype PubMed ID
nsv976573 CNV duplication 23825009
nsv8914 CNV loss 18304495
nsv832328 CNV gain 17160897
nsv606 CNV deletion 18451855
nsv557465 CNV gain 21841781
nsv521062 CNV gain 19592680
nsv435631 CNV deletion 17901297
nsv1138097 CNV deletion 24896259
nsv1131038 CNV deletion 24896259
nsv1051292 CNV loss 25217958
nsv1036390 CNV loss 25217958
esv4003 CNV loss 18987735
esv3892136 CNV loss 25118596
esv3628535 CNV loss 21293372
esv3580111 CNV loss 25503493
esv32543 CNV loss 17666407
esv2745535 CNV deletion 23290073
esv25005 CNV loss 19812545
dgv270n67 CNV loss 20364138
dgv263e199 CNV deletion 23128226
dgv250e214 CNV loss 21293372
dgv2359n54 CNV loss 21841781
dgv2358n54 CNV loss 21841781

Variation tolerance for KLRC3 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLRC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC3 Gene

Disorders for KLRC3 Gene

Relevant External Links for KLRC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRC3 Gene

Publications for KLRC3 Gene

  1. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PMID: 11751968) Shum B.P. … Parham P. (J. Immunol. 2002) 3 4 22 64
  2. Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer. (PMID: 10201920) Bellon T. … Aparicio P. (J. Immunol. 1999) 3 4 22 64
  3. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B. … Trowsdale J. (Genomics 1998) 2 3 64
  4. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PMID: 9683661) Glienke J. … Francis F. (Immunogenetics 1998) 3 4 64
  5. Natural killer lectin-like receptors have divergent carboxy-termini, distinct from C-type lectins. (PMID: 8276468) Adamkiewicz T.V. … Houchins J.P. (Immunogenetics 1994) 3 4 64

Products for KLRC3 Gene

Sources for KLRC3 Gene

Loading form....