Aliases for KLRC3 Gene
External Ids for KLRC3 Gene
Previous GeneCards Identifiers for KLRC3 Gene
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLRC3 Gene
KLRC3 (Killer Cell Lectin-Like Receptor Subfamily C, Member 3) is a Protein Coding gene. Diseases associated with KLRC3 include monkeypox. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is KLRC1.
UniProtKB/Swiss-Prot for KLRC3 Gene
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells