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Aliases for KLRC2 Gene

Aliases for KLRC2 Gene

  • Killer Cell Lectin Like Receptor C2 2 3
  • Killer Cell Lectin-Like Receptor Subfamily C, Member 2 2 3 5
  • CD159 Antigen-Like Family Member C 3 4
  • NKG2-C-Activating NK Receptor 3 4
  • NK Cell Receptor C 3 4
  • NKG2C 3 4
  • CD159c Antigen 4
  • CD159c 3
  • NKG2-C 3

External Ids for KLRC2 Gene

Previous GeneCards Identifiers for KLRC2 Gene

  • GC12P010266
  • GC12U900034
  • GC12M010484
  • GC12M010474
  • GC12M010583
  • GC12M010690
  • GC12M010719

Summaries for KLRC2 Gene

Entrez Gene Summary for KLRC2 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRC2 Gene

KLRC2 (Killer Cell Lectin Like Receptor C2) is a Protein Coding gene. Diseases associated with KLRC2 include Hypersensitivity Syndrome, Carbamazepine-Induced and Behcet's Disease. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity and MHC class I protein complex binding. An important paralog of this gene is KLRC1.

UniProtKB/Swiss-Prot for KLRC2 Gene

  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Gene Wiki entry for KLRC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC2 Gene

Genomics for KLRC2 Gene

Regulatory Elements for KLRC2 Gene

Enhancers for KLRC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLRC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLRC2 Gene

10,426,854 bp from pter
10,442,300 bp from pter
15,447 bases
Minus strand

Genomic View for KLRC2 Gene

Genes around KLRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC2 Gene

Proteins for KLRC2 Gene

  • Protein details for KLRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NKG2-C type II integral membrane protein
    Protein Accession:
    Secondary Accessions:
    • O43802
    • Q52M74
    • Q9NR42

    Protein attributes for KLRC2 Gene

    231 amino acids
    Molecular mass:
    26072 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.

    Three dimensional structures from OCA and Proteopedia for KLRC2 Gene

neXtProt entry for KLRC2 Gene

Proteomics data for KLRC2 Gene at MOPED

Post-translational modifications for KLRC2 Gene

  • Glycosylation at Asn 100, Asn 149, and Asn 178

Other Protein References for KLRC2 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for KLRC2

No data available for DME Specific Peptides for KLRC2 Gene

Domains & Families for KLRC2 Gene

Gene Families for KLRC2 Gene

Protein Domains for KLRC2 Gene

Suggested Antigen Peptide Sequences for KLRC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRC2: view

Function for KLRC2 Gene

Molecular function for KLRC2 Gene

GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily C,member 2
UniProtKB/Swiss-Prot Function:
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Gene Ontology (GO) - Molecular Function for KLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990405 protein antigen binding IDA 18448674
genes like me logo Genes that share ontologies with KLRC2: view
genes like me logo Genes that share phenotypes with KLRC2: view

Animal Model Products

miRNA for KLRC2 Gene

miRTarBase miRNAs that target KLRC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC2 Gene

Localization for KLRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for KLRC2 Gene COMPARTMENTS Subcellular localization image for KLRC2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KLRC2 Gene

Pathways & Interactions for KLRC2 Gene

genes like me logo Genes that share pathways with KLRC2: view

Gene Ontology (GO) - Biological Process for KLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2007850
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with KLRC2: view

No data available for SIGNOR curated interactions for KLRC2 Gene

Drugs & Compounds for KLRC2 Gene

No Compound Related Data Available

Transcripts for KLRC2 Gene

Unigene Clusters for KLRC2 Gene

Killer cell lectin-like receptor subfamily C, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC2 Gene

No ASD Table

Relevant External Links for KLRC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRC2 Gene

mRNA expression in normal human tissues for KLRC2 Gene

mRNA differential expression in normal tissues according to GTEx for KLRC2 Gene

This gene is overexpressed in Brain - Amygdala (x5.2) and Brain - Substantia nigra (x4.4).

SOURCE GeneReport for Unigene cluster for KLRC2 Gene Hs.591157

mRNA Expression by UniProt/SwissProt for KLRC2 Gene

Tissue specificity: Natural killer cells.
genes like me logo Genes that share expression patterns with KLRC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KLRC2 Gene

Orthologs for KLRC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC609192 35
  • 74.24 (n)
  • 59.74 (a)
-- 36
  • 54 (a)
(Pan troglodytes)
Mammalia LOC101058094 35
  • 97.11 (n)
  • 94.81 (a)
KLRC2 36
  • 94 (a)
(Bos Taurus)
Mammalia -- 36
  • 48 (a)
(Mus musculus)
Mammalia Klre1 36
  • 24 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
Species with no ortholog for KLRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC2 Gene

Gene Tree for KLRC2 (if available)
Gene Tree for KLRC2 (if available)

Paralogs for KLRC2 Gene

Paralogs for KLRC2 Gene Pseudogenes for KLRC2 Gene

genes like me logo Genes that share paralogs with KLRC2: view

Variants for KLRC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC2 Gene

Two alleles are known. The sequence shown is that of allele NKG2-C*01.

Sequence variations from dbSNP and Humsavar for KLRC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs28403159 - 10,435,982(+) GTTTA(C/T)TCATC reference, missense
VAR_013405 -
rs3003 -- 10,431,012(-) GCTCT(A/G)ATACA utr-variant-3-prime
rs10845128 -- 10,432,484(+) TCATT(C/T)CTCCA intron-variant
rs28730284 -- 10,436,048(+) TATAA(A/G)TGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLRC2 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv832328 CNV Gain 17160897
nsv898759 CNV Loss 21882294
nsv898763 CNV Loss 21882294
nsv8914 CNV Loss 18304495
dgv1371n71 CNV Loss 21882294
nsv606 CNV Loss 18451855
nsv898767 CNV Loss 21882294
nsv521062 CNV Gain 19592680
esv4003 CNV Deletion 18987735
dgv1372n71 CNV Loss 21882294
nsv898769 CNV Gain 21882294
esv25005 CNV Loss 19812545
dgv263e199 CNV Deletion 23128226
esv2745535 CNV Deletion 23290073
dgv270n67 CNV Loss 20364138
esv32543 CNV Loss 17666407
nsv435631 CNV Deletion 17901297
esv8275 CNV Loss 19470904
dgv190e201 CNV Deletion 23290073
dgv264e199 CNV Deletion 23128226
nsv442633 CNV CNV 18776908
nsv514645 CNV Gain 21397061

Variation tolerance for KLRC2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLRC2 Gene

Human Gene Mutation Database (HGMD)

Disorders for KLRC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLRC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypersensitivity syndrome, carbamazepine-induced
  • toxic epidermal necrolysis
behcet's disease
  • adamantiades-behcet disease
- elite association - COSMIC cancer census association via MalaCards
Search KLRC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLRC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KLRC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLRC2 Gene

Publications for KLRC2 Gene

  1. Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. (PMID: 14688071) Miyashita R. … Tokunaga K. (Int. Immunol. 2004) 3 23 48 67
  2. Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses. (PMID: 15550116) Ortega C. … SantamarA-a M. (Immunol. Cell Biol. 2004) 3 23
  3. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PMID: 12618865) Hikami K. … Tokunaga K. (Genes Immun. 2003) 3 23
  4. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B. … Trowsdale J. (Genomics 1998) 2 3
  5. Association of DAP12 with activating CD94/NKG2C NK cell receptors. (PMID: 9655483) Lanier L.L. … Phillips J.H. (Immunity 1998) 3 23

Products for KLRC2 Gene

Sources for KLRC2 Gene