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Aliases for KLRC2 Gene

Aliases for KLRC2 Gene

  • Killer Cell Lectin-Like Receptor Subfamily C, Member 2 2 3
  • NKG2C 3 4 6
  • CD159 Antigen-Like Family Member C 3 4
  • NKG2-C-Activating NK Receptor 3 4
  • NK Cell Receptor C 3 4
  • NKG2-C Type II Integral Membrane Protein 3
  • CD159c Antigen 4
  • CD159c 3
  • NKG2-C 3

External Ids for KLRC2 Gene

Previous GeneCards Identifiers for KLRC2 Gene

  • GC12P010266
  • GC12U900034
  • GC12M010484
  • GC12M010583
  • GC12M010690

Summaries for KLRC2 Gene

Entrez Gene Summary for KLRC2 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRC2 Gene

KLRC2 (Killer Cell Lectin-Like Receptor Subfamily C, Member 2) is a Protein Coding gene. Diseases associated with KLRC2 include rheumatic disease and paroxysmal nocturnal hemoglobinuria. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is KLRC1.

UniProtKB/Swiss-Prot for KLRC2 Gene

  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells

Gene Wiki entry for KLRC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC2 Gene

Genomics for KLRC2 Gene

Regulatory Elements for KLRC2 Gene

Genomic Location for KLRC2 Gene

10,426,854 bp from pter
10,442,300 bp from pter
15,447 bases
Minus strand

Genomic View for KLRC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC2 Gene

Proteins for KLRC2 Gene

  • Protein details for KLRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NKG2-C type II integral membrane protein
    Protein Accession:
    Secondary Accessions:
    • O43802
    • Q52M74
    • Q9NR42

    Protein attributes for KLRC2 Gene

    231 amino acids
    Molecular mass:
    26072 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.

    Three dimensional structures from OCA and Proteopedia for KLRC2 Gene

neXtProt entry for KLRC2 Gene

Proteomics data for KLRC2 Gene at MOPED

Post-translational modifications for KLRC2 Gene

  • Glycosylation at Asn100, Asn149, and Asn178

Other Protein References for KLRC2 Gene

Antibody Products

No data available for DME Specific Peptides for KLRC2 Gene

Domains for KLRC2 Gene

Gene Families for KLRC2 Gene

Protein Domains for KLRC2 Gene

Suggested Antigen Peptide Sequences for KLRC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with KLRC2: view

Function for KLRC2 Gene

Molecular function for KLRC2 Gene

GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily C,member 2
UniProtKB/Swiss-Prot Function:
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells

Gene Ontology (GO) - Molecular Function for KLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9683661
GO:0005515 protein binding IPI 18448674
GO:0023024 MHC class I protein complex binding IPI 18448674
GO:0030246 carbohydrate binding IEA --
GO:1990405 protein antigen binding IDA 18448674
genes like me logo Genes that share ontologies with KLRC2: view

Animal Model Products

miRNA for KLRC2 Gene

miRTarBase miRNAs that target KLRC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLRC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC2 Gene

Localization for KLRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for KLRC2 Gene COMPARTMENTS Subcellular localization image for KLRC2 gene
Compartment Confidence
plasma membrane 4
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8436421
GO:0043235 receptor complex IDA 18448674
genes like me logo Genes that share ontologies with KLRC2: view

Pathways for KLRC2 Gene

genes like me logo Genes that share pathways with KLRC2: view

Pathways by source for KLRC2 Gene

1 GeneGo (Thomson Reuters) pathway for KLRC2 Gene

Gene Ontology (GO) - Biological Process for KLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002228 natural killer cell mediated immunity IDA 18448674
GO:0006968 cellular defense response TAS 9683661
GO:0007165 signal transduction TAS 2007850
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with KLRC2: view

Transcripts for KLRC2 Gene

Unigene Clusters for KLRC2 Gene

Killer cell lectin-like receptor subfamily C, member 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLRC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC2 Gene

No ASD Table

Relevant External Links for KLRC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRC2 Gene

mRNA expression in normal human tissues for KLRC2 Gene

mRNA differential expression in normal tissues according to GTEx for KLRC2 Gene

This gene is overexpressed in Brain - Amygdala (5.2) and Brain - Substantia nigra (4.4).

SOURCE GeneReport for Unigene cluster for KLRC2 Gene Hs.591157

mRNA Expression by UniProt/SwissProt for KLRC2 Gene

Tissue specificity: Natural killer cells
genes like me logo Genes that share expressions with KLRC2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for KLRC2 Gene

Orthologs for KLRC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC609192 35
  • 74.24 (n)
  • 59.74 (a)
-- 36
  • 54 (a)
(Pan troglodytes)
Mammalia LOC101058094 35
  • 97.11 (n)
  • 94.81 (a)
KLRC2 36
  • 94 (a)
(Mus musculus)
Mammalia Klrc2 16
Klre1 36
  • 24 (a)
(Bos Taurus)
Mammalia -- 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
Species with no ortholog for KLRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC2 Gene

Gene Tree for KLRC2 (if available)
Gene Tree for KLRC2 (if available)

Paralogs for KLRC2 Gene

Paralogs for KLRC2 Gene Pseudogenes for KLRC2 Gene

genes like me logo Genes that share paralogs with KLRC2: view

Variants for KLRC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC2 Gene

Two alleles are known. The sequence shown is that of allele NKG2-C*01

Sequence variations from dbSNP and Humsavar for KLRC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3003 -- 10,431,012(-) GCTCT(A/G)ATACA utr-variant-3-prime
rs1141715 -- 10,434,512(-) CAATT(C/T)TTCCC missense, reference
rs1141716 -- 10,433,791(-) GAAAT(A/G)AAATT missense, reference
rs1356930 -- 10,434,362(-) TATTT(A/G)TAAAG intron-variant
rs1915318 -- 10,437,166(+) TGTTT(A/G)GTTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLRC2 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv832328 CNV Gain 17160897
nsv898759 CNV Loss 21882294
nsv898763 CNV Loss 21882294
nsv8914 CNV Loss 18304495
dgv1371n71 CNV Loss 21882294
nsv606 CNV Loss 18451855
nsv898767 CNV Loss 21882294
nsv521062 CNV Gain 19592680
esv4003 CNV Deletion 18987735
dgv1372n71 CNV Loss 21882294
nsv898769 CNV Gain 21882294
esv25005 CNV Loss 19812545
dgv263e199 CNV Deletion 23128226
esv2745535 CNV Deletion 23290073
dgv270n67 CNV Loss 20364138
esv32543 CNV Loss 17666407
nsv435631 CNV Deletion 17901297
esv8275 CNV Loss 19470904
dgv190e201 CNV Deletion 23290073
dgv264e199 CNV Deletion 23128226
nsv442633 CNV CNV 18776908
nsv514645 CNV Gain 21397061

Relevant External Links for KLRC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for KLRC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KLRC2 Gene in MalaCards »

(2) Diseases for KLRC2 Gene

(3) Novoseek inferred disease relationships for KLRC2 Gene

Disease -log(P) Hits PubMed IDs
rheumatic diseases 45.4 1
lupus erythematosus systemic 26.1 2
rheumatoid arthritis 15.8 2

Relevant External Links for KLRC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLRC2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for KLRC2 Gene

Publications for KLRC2 Gene

  1. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PMID: 12618865) Hikami K. … Tokunaga K. (Genes Immun. 2003) 3 23 48
  2. Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. (PMID: 14688071) Miyashita R. … Tokunaga K. (Int. Immunol. 2004) 3 23 48
  3. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. (PMID: 8943374) Lazetic S. … Phillips J.H. (J. Immunol. 1996) 3 23
  4. Association of DAP12 with activating CD94/NKG2C NK cell receptors. (PMID: 9655483) Lanier L.L. … Phillips J.H. (Immunity 1998) 3 23
  5. Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses. (PMID: 15550116) Ortega C. … SantamarA-a M. (Immunol. Cell Biol. 2004) 3 23

Products for KLRC2 Gene

Sources for KLRC2 Gene

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