Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLRC2 Gene

protein-coding   GIFtS: 60
GCID: GC12M010583

Killer Cell Lectin-Like Receptor Subfamily C, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Lectin-Like Receptor Subfamily C, Member 21 2     CD159c2
NKG2C2 3 5     NKG2-C2
CD159 Antigen-Like Family Member C2 3     NKG2-C Type II Integral Membrane Protein2
NK Cell Receptor C2 3     CD159c Antigen3
NKG2-C-Activating NK Receptor2 3     

External Ids:    HGNC: 63751   Entrez Gene: 38222   Ensembl: ENSG000002058097   OMIM: 6028915   UniProtKB: P267173   

Export aliases for KLRC2 gene to outside databases

Previous GC identifers: GC12P010266 GC12U900034 GC12M010484 GC12M010474


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLRC2 Gene:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells
without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells
preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation
of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and
encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C
terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK
complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2
alternative splice variants have been described but their full-length nature has not been determined. (provided
by RefSeq, Jul 2008)

GeneCards Summary for KLRC2 Gene: 
KLRC2 (killer cell lectin-like receptor subfamily C, member 2) is a protein-coding gene. Diseases associated with KLRC2 include paroxysmal nocturnal hemoglobinuria, and toxic epidermal necrolysis, and among its related super-pathways are Immune response Role of DAP12 receptors in NK cells and DAP12 interactions. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is KLRD1.

UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717
Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
cytotoxic T-cells

Gene Wiki entry for KLRC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLRC2 gene promoter:
         Pax-3   AP-1   Bach2   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLRC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

KLRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRC2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010583:  view genomic region     (about GC identifiers)

Start:
10,579,453 bp from pter      End:
10,594,899 bp from pter
Size:
15,447 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717 (See protein sequence)
Recommended Name: NKG2-C type II integral membrane protein  
Size: 231 amino acids; 26072 Da
Subunit: Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP
Subcellular location: Membrane; Single-pass type II membrane protein
1 PDB 3D structure from and Proteopedia for KLRC2:
2L35 (3D)    
Secondary accessions: O43802 Q52M74 Q9NR42

Explore the universe of human proteins at neXtProt for KLRC2: NX_P26717

Explore proteomics data for KLRC2 at MOPED 

KLRC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KLRC2 Protein Expression

REFSEQ proteins: NP_002251.2  
ENSEMBL proteins: 
 ENSP00000438983   ENSP00000371327   ENSP00000444754   ENSP00000445240   ENSP00000371326  
Reactome Protein details: P26717
Human Recombinant Protein Products for KLRC2: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for KLRC2
OriGene Custom MassSpec 
OriGene Custom Protein Services for KLRC2
GenScript Custom Purified and Recombinant Proteins Services for KLRC2
Novus Biologicals KLRC2 Proteins
Novus Biologicals KLRC2 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for KLRC2
Cloud-Clone Corp. Proteins for KLRC2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS8436421

KLRC2 for ontologies           About GeneDecksing



KLRC2 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for KLRC2 (NKG2C/CD159c)
Browse OriGene Antibodies
OriGene Custom Antibody Services for KLRC2
GenScript Custom Superior Antibodies Services for KLRC2
Novus Biologicals KLRC2 Antibodies
Abcam antibodies for KLRC2
Cloud-Clone Corp. Antibodies for KLRC2 
ThermoFisher Antibodies for KLRC2
LSBio Antibodies in human, mouse, rat for KLRC2 

Assay Products for KLRC2: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for KLRC2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for KLRC2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for KLRC2 
Cloud-Clone Corp. CLIAs for KLRC2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KLR: Killer cell lectin-like receptors
CD: CD molecules

3 InterPro protein domains:
 IPR016187 C-type_lectin_fold
 IPR016186 C-type_lectin-like
 IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry P26717

ProtoNet protein and cluster: P26717

UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717
Similarity: Contains 1 C-type lectin domain


KLRC2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NKG2C_HUMAN, P26717
Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
cytotoxic T-cells

     Genatlas biochemistry entry for KLRC2:
natural killer cell lectin-like receptor subfamily C,member 2

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004888transmembrane signaling receptor activity TAS9683661
GO:0005515protein binding IPI--
GO:0030246carbohydrate binding IEA--
     
KLRC2 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for KLRC2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLRC2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLRC2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLRC2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLRC2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLRC2
SwitchGear 3'UTR luciferase reporter plasmidKLRC2 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for KLRC2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRC2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for KLRC2
Sirion Biotech Customized adenovirus for overexpression of KLRC2

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for KLRC2 (see all 8)
OriGene ORF clones in mouse, rat for KLRC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KLRC2 (NM_002260)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLRC2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2
Sirion Biotech Customized lentivirus for stable overexpression of KLRC2 
                     Customized lentivirus expression plasmids for stable overexpression of KLRC2 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for KLRC2
Search LifeMap BioReagents cell lines for KLRC2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KLRC2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune response Fc epsilon RI pathway
Immune response Role of DAP12 receptors in NK cells0.32
Natural killer cell mediated cytotoxicity0.31
2Signaling by FGFR
DAP12 signaling0.91
DAP12 interactions0.91
3Immune System
Immune System0.56
Innate Immune System0.50
4Allograft rejection
Antigen processing and presentation0.37

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for KLRC2
    Immune response Role of DAP12 receptors in NK cells


1 GeneGo (Thomson Reuters) Pathway for KLRC2
    Immune response Role of DAP12 receptors in NK cells

4        Reactome Pathways for KLRC2
    DAP12 interactions
DAP12 signaling
Immune System
Innate Immune System


2         Kegg Pathways  (Kegg details for KLRC2):
    Antigen processing and presentation
Natural killer cell mediated cytotoxicity


KLRC2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLRC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/12 Interacting proteins for KLRC2 (P267171, 3 ENSP000003713274) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
TYROBPO439141, 3, ENSP000002626294EBI-3862171,EBI-2214794 I2D: score=1 STRING: ENSP00000262629
ENSG00000229252P137473, ENSP000004099104I2D: score=1 STRING: ENSP00000409910
HLA-EP137473, ENSP000003658174I2D: score=1 STRING: ENSP00000365817
ENSG00000206493P137473I2D: score=1 
ENSG00000230254P137473I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006968cellular defense response TAS9683661
GO:0007165signal transduction TAS2007850
GO:0045087innate immune response TAS--

KLRC2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLRC2 (NKG2C)

Search CenterWatch for drugs/clinical trials and news about KLRC2 / NKG2C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLRC2 gene: 
NM_002260.3  

Unigene Cluster for KLRC2:

Killer cell lectin-like receptor subfamily C, member 2
Hs.591157  [show with all ESTs]
Unigene Representative Sequence: NM_002260
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000535069 ENST00000381902(uc010she.1 uc001qyk.2) ENST00000536833
ENST00000537017 ENST00000381901
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLRC2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLRC2
SwitchGear 3'UTR luciferase reporter plasmidKLRC2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for KLRC2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRC2
Clone
Products:
     
OriGene clones in human, mouse for KLRC2 (see all 8)
OriGene ORF clones in mouse, rat for KLRC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KLRC2 (NM_002260)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLRC2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2
Sirion Biotech Customized lentivirus for stable overexpression of KLRC2 
                     Customized lentivirus expression plasmids for stable overexpression of KLRC2 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for KLRC2
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat KLRC2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRC2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRC2

Additional mRNA sequence: 

AF260134.1 AK295525.1 BC093644.1 BC106069.1 BC112039.1 X54869.1 Y13055.1 

4 DOTS entries:

DT.100783358  DT.75132896  DT.121197028  DT.91722289 

24/53 AceView cDNA sequences (see all 53):

X54868 NM_007328 X54867 NM_213658 AF260134 NM_213657 NM_002259 BC053840 
AA190627 AA191156 BI335443 AA913480 BX280271 N68872 BX330986 BG218887 
CD639096 AF461812 CA396224 X54869 Y13055 BX282341 NM_002260 BG057689 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLRC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACACTTCAAT
KLRC2 Expression
About this image


See KLRC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLRC2

SOURCE GeneReport for Unigene cluster: Hs.591157

UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717
Tissue specificity: Natural killer cells

    SABiosciences Custom PCR Arrays for KLRC2
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for KLRC2
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat KLRC2
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRC2
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRC2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for KLRC2 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Klrc25 killer cell lectin-like receptor subfamily C, member more   --   6 (63.44 cM) 129647496 


ENSEMBL Gene Tree for KLRC2 (if available)
TreeFam Gene Tree for KLRC2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KLRC2 gene
KLRD12  KLRK12  KLRC42  KLRC4-KLRK12  ENSG000002556412  KLRC12  KLRC32  
18 SIMAP similar genes for KLRC2 using alignment to 6 protein entries:     NKG2C_HUMAN (see all proteins):
KLRC3    KLRC1    KLRC4    KLRK1    FCER2    KLRF1
CLEC1B    CLEC2D    SELP    REG1A    CLEC2L    OLR1
KLRG1    CLEC4C    KLRD1    CLEC2B    CLEC5A    CLEC10A

KLRC2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for KLRC2
PGOHUM00000237791


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717
Polymorphism: Two alleles are known. The sequence shown is that of allele NKG2-C*01


10/255 SNPs in KLRC2 are shown (see all 255)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0134054
----see VAR_0134052 S F mis40--------
rs344725321,2
C--10582710(+) ATTGTG/ACCTTC 1 -- ds50011Minor allele frequency- A:0.50NA 2
rs27344201,2
C,F,A--10582739(-) GGCTAA/GGGTTT 1 -- ds50015Minor allele frequency- G:0.33NA CSA 9
rs350601871,2
--10582771(+) AACTAA/CGTTAT 1 -- ds50010--------
rs581704541,2
C,F--10582772(+) ACTAAG/ATTATA 1 -- ds50013Minor allele frequency- A:0.18WA 122
rs348178011,2
C--10582812(+) ATCATG/TTGCAG 1 -- ds50011Minor allele frequency- T:0.50NA 2
rs355197611,2
C--10582830(+) TGCTCG/ATTATA 1 -- ds50011Minor allele frequency- A:0.50NA 2
rs124258401,2
C,H--10582879(+) ATTTAA/CATATA 1 -- ds50013Minor allele frequency- C:0.17NA WA EA 240
rs348726421,2
--10582997(+) TTACAA/GAAGCA 1 -- ds50010--------
rs358874501,2
C,F--10583061(+) TACAAG/TAGAGA 1 -- ds50011Minor allele frequency- T:0.50NA 2

HapMap Linkage Disequilibrium report for KLRC2 (10579453 - 10594899 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/23 variations for KLRC2 (see all 23):    About this table     
Variant IDTypeSubtypePubMed ID
dgv190e201CNV Deletion23290073
dgv263e199CNV Deletion23128226
dgv264e199CNV Deletion23128226
esv4003CNV Deletion18987735
nsv435631CNV Deletion17901297
esv2745535CNV Deletion23290073
esv32543CNV Loss17666407
esv8275CNV Loss19470904
nsv898759CNV Loss21882294
nsv898763CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing KLRC2
DNA2.0 Custom Variant and Variant Library Synthesis for KLRC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 602891    OMIM disorders: --

10 diseases for KLRC2:    About MalaCards
paroxysmal nocturnal hemoglobinuria    toxic epidermal necrolysis    stevens-johnson syndrome    hemoglobinuria
behcet's disease    pre-eclampsia    eclampsia    rheumatoid arthritis
arthritis    lupus erythematosus


KLRC2 for disorders           About GeneDecksing

3 Novoseek inferred disease relationships for KLRC2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatic diseases 45.4 2 14688071 (1)
lupus erythematosus systemic 26.1 3 14688071 (1), 12618865 (1)
rheumatoid arthritis 15.8 3 14688071 (1), 12618865 (1)

Genetic Association Database (GAD): KLRC2
Human Genome Epidemiology (HuGE) Navigator: KLRC2 (5 documents)

Export disorders for KLRC2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KLRC2 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with KLRC2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. (PubMed id 14688071)1, 4, 9 Miyashita R....Tokunaga K. (2004)
  2. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PubMed id 12618865)1, 4, 9 Hikami K....Tokunaga K. (2003)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  4. Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis. (PubMed id 18700876)1, 4 Park K.S....Song Y.W. (2008)
  5. Association of CD94/NKG2A, CD94/NKG2C, and its ligand HLA-E polymorphisms with Behcet's disease. (PubMed id 17767552)1, 4 Seo J....Park K.S. (2007)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PubMed id 11751968)1, 2 Shum B.P.... Parham P. (2002)
  8. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PubMed id 9683661)1, 2 Glienke J.... Francis F. (1998)
  9. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PubMed id 9598306)1, 3 Plougastel B. and Trowsdale J. (1998)
  10. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PubMed id 2007850)1, 2 Houchins J.P....Bach F.H. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3822 HGNC: 6375 AceView: KLRC1 Ensembl:ENSG00000205809 euGenes: HUgn3822
ECgene: KLRC2 Kegg: 3822 H-InvDB: KLRC2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KLRC2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KLRC2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KLRC2 gene:
Search GeneIP for patents involving KLRC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for KLRC2 (NKG2C/CD159c)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLRC2  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KLRC2  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for KLRC2  
 OriGene qSTAR qPCR primer pairs in human, mouse for KLRC2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for KLRC2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for KLRC2   OriGene Custom Protein Services for KLRC2  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLRC2
 QIAGEN SeqTarget long-range PCR primers for resequencing KLRC2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRC2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRC2
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRC2
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRC2
 GenScript Custom Purified and Recombinant Proteins Services for KLRC2 GenScript cDNA clones with any tag delivered in your preferred vector for KLRC2
 GenScript Custom Assay Services for KLRC2 GenScript Custom Superior Antibodies Services for KLRC2
 GenScript Custom overexpressing Cell Line Services for KLRC2 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in KLRC2 promoter
 Search Chromatin IP Primers for KLRC2
 RT2 qPCR Primer Assay in human, mouse / rat KLRC2
 GNC Network for KLRC2
 SABiosciences Custom PCR Arrays for KLRC2
 Search Tocris compounds for KLRC2 (NKG2C)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 KLRC2 antibodies
 KLRC2 proteins
 KLRC2 lysates
 Antibodies for KLRC2
 See all of Abcam's Antibodies, Kits and Proteins for KLRC2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for KLRC2




 Proteins for KLRC2
 Antibodies for KLRC2
 ELISAs for KLRC2
 CLIAs for KLRC2
 Search LifeMap BioReagents cell lines for KLRC2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2
 SwitchGear 3'UTR luciferase reporter plasmids for KLRC2
 SwitchGear Promoter luciferase reporter plasmids for KLRC2
 ThermoFisher Antibodies for KLRC2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2
 inGenious Targeting Laboratory - Custom generated mouse model solutions for KLRC2
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLRC2
Customized:
 lentivirus for stable overexpression of KLRC2
 lentivirus expression plasmids for stable overexpression of KLRC2
 adenovirus for overexpression of KLRC2
 LSBio Antibodies in human, mouse, rat for KLRC2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      KLRC2 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4