Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KLRC2 Gene

protein-coding   GIFtS: 62
GCID: GC12M010690

Killer Cell Lectin-Like Receptor Subfamily C, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Killer Cell Lectin-Like Receptor Subfamily C, Member 21 2     CD159c2
NKG2C2 3 5     NKG2-C2
CD159 Antigen-Like Family Member C2 3     NKG2-C Type II Integral Membrane Protein2
NK Cell Receptor C2 3     CD159c Antigen3
NKG2-C-Activating NK Receptor2 3     

External Ids:    HGNC: 63751   Entrez Gene: 38222   Ensembl: ENSG000002058097   OMIM: 6028915   UniProtKB: P267173   

Export aliases for KLRC2 gene to outside databases

Previous GC identifers: GC12P010266 GC12U900034 GC12M010484 GC12M010474 GC12M010583


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KLRC2 Gene:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells
without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells
preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation
of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and
encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C
terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK
complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2
alternative splice variants have been described but their full-length nature has not been determined. (provided
by RefSeq, Jul 2008)

GeneCards Summary for KLRC2 Gene:
KLRC2 (killer cell lectin-like receptor subfamily C, member 2) is a protein-coding gene. Diseases associated with KLRC2 include paroxysmal nocturnal hemoglobinuria, and stevens-johnson syndrome. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is KLRD1.

UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717
Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
cytotoxic T-cells

Gene Wiki entry for KLRC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLRC2 gene promoter:
         Pax-3   AP-1   Bach2   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRC2 promoter sequence
   Search Chromatin IP Primers for KLRC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

KLRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRC2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010690:  view genomic region     (about GC identifiers)

Start:
10,579,453 bp from pter      End:
10,594,899 bp from pter
Size:
15,447 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717 (See protein sequence)
Recommended Name: NKG2-C type II integral membrane protein  
Size: 231 amino acids; 26072 Da
Subunit: Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP
1 PDB 3D structure from and Proteopedia for KLRC2:
2L35 (3D)    
Secondary accessions: O43802 Q52M74 Q9NR42

Explore the universe of human proteins at neXtProt for KLRC2: NX_P26717

Explore proteomics data for KLRC2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn100, Asn149, Asn178

  • See KLRC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002251.2  
    ENSEMBL proteins: 
     ENSP00000438983   ENSP00000371327   ENSP00000444754   ENSP00000445240   ENSP00000371326  
    Reactome Protein details: P26717

    KLRC2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KLRC2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KLRC2
    GenScript Custom Purified and Recombinant Proteins Services for KLRC2
    Novus Biologicals KLRC2 Proteins
    Novus Biologicals KLRC2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for KLRC2
    Cloud-Clone Corp. Proteins for KLRC2

    KLRC2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KLRC2 (NKG2C/CD159c)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLRC2
    Novus Biologicals KLRC2 Antibodies
    Abcam antibodies for KLRC2
    Cloud-Clone Corp. Antibodies for KLRC2
    ThermoFisher Antibodies for KLRC2
    LSBio Antibodies in human, mouse, rat for KLRC2

    KLRC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLRC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLRC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLRC2
    Cloud-Clone Corp. CLIAs for KLRC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KLR: Killer cell lectin-like receptors
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P26717

    ProtoNet protein and cluster: P26717

    UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717
    Similarity: Contains 1 C-type lectin domain


    KLRC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKG2C_HUMAN, P26717
    Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
    cytotoxic T-cells

         Genatlas biochemistry entry for KLRC2:
    natural killer cell lectin-like receptor subfamily C,member 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9683661
    GO:0005515protein binding IPI--
    GO:0030246carbohydrate binding IEA--
         
    KLRC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLRC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLRC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLRC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLRC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLRC2:
    hsa-mir-335-5p (MIRT017833), hsa-mir-26b-5p (MIRT029433)

    Block miRNA regulation of human, mouse, rat KLRC2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLRC2
    SwitchGear 3'UTR luciferase reporter plasmidKLRC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLRC2
    Predesigned siRNA for gene silencing in human, mouse, rat KLRC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLRC2

    Clone
    Products:
         
    OriGene clones in human, mouse for KLRC2 (see all 8)
    OriGene ORF clones in mouse, rat for KLRC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLRC2 (NM_002260)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLRC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLRC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLRC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NKG2C_HUMAN, P26717: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8436421

    KLRC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KLRC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    2Signaling by FGFR
    DAP12 signaling0.89
    DAP12 interactions0.89
    3Allograft rejection
    Antigen processing and presentation0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KLRC2
        Immune response Role of DAP12 receptors in NK cells

    2 Reactome Pathways for KLRC2
        DAP12 interactions
    DAP12 signaling


    2 Kegg Pathways  (Kegg details for KLRC2):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    KLRC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLRC2
    Interactions:

        GeneGlobe Interaction Network for KLRC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for KLRC2 (P267171, 3 ENSP000003713274) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPO439141, 3, ENSP000002626294EBI-3862171,EBI-2214794 I2D: score=1 STRING: ENSP00000262629
    ENSG00000229252P137473, ENSP000004099104I2D: score=1 STRING: ENSP00000409910
    HLA-EP137473, ENSP000003658174I2D: score=1 STRING: ENSP00000365817
    ENSG00000206493P137473I2D: score=1 
    ENSG00000230254P137473I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS9683661
    GO:0007165signal transduction TAS2007850
    GO:0045087innate immune response TAS--

    KLRC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLRC2 (NKG2C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KLRC2 gene: 
    NM_002260.3  

    Unigene Cluster for KLRC2:

    Killer cell lectin-like receptor subfamily C, member 2
    Hs.591157  [show with all ESTs]
    Unigene Representative Sequence: NM_002260
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535069 ENST00000381902(uc010she.1 uc001qyk.2) ENST00000536833
    ENST00000537017 ENST00000381901
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLRC2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLRC2
    SwitchGear 3'UTR luciferase reporter plasmidKLRC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLRC2
    Predesigned siRNA for gene silencing in human, mouse, rat KLRC2
    Clone
    Products:
         
    OriGene clones in human, mouse for KLRC2 (see all 8)
    OriGene ORF clones in mouse, rat for KLRC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLRC2 (NM_002260)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLRC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLRC2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KLRC2
      QuantiTect SYBR Green Assays in human, mouse, rat KLRC2
      QuantiFast Probe-based Assays in human, mouse, rat KLRC2

    Additional mRNA sequence: 

    AF260134.1 AK295525.1 BC093644.1 BC106069.1 BC112039.1 X54869.1 Y13055.1 

    4 DOTS entries:

    DT.100783358  DT.75132896  DT.121197028  DT.91722289 

    Selected AceView cDNA sequences (see all 53):

    NM_213658 AA191156 BC053840 X54867 NM_213657 X54868 NM_002259 AA190627 
    NM_007328 AF260134 BF529720 AA913480 BX350415 Y13055 CD639096 BX330986 
    BI335443 BG057689 BX280271 BC012550 AF461812 X54869 NM_002260 BG218887 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KLRC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTTCAAT
    KLRC2 Expression
    About this image

    KLRC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLRC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591157

    UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717
    Tissue specificity: Natural killer cells

        Custom PCR Arrays for KLRC2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLRC2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KLRC2
    QuantiTect SYBR Green Assays in human, mouse, rat KLRC2
    QuantiFast Probe-based Assays in human, mouse, rat KLRC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLRC2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrc25 killer cell lectin-like receptor subfamily C, member more   --   6 (63.44 cM) 129647496 


    ENSEMBL Gene Tree for KLRC2 (if available)
    TreeFam Gene Tree for KLRC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KLRC2 gene
    KLRD12  KLRK12  KLRC42  KLRC4-KLRK12  ENSG000002556412  KLRC12  KLRC32  
    Selected SIMAP similar genes for KLRC2 using alignment to 6 protein entries:     NKG2C_HUMAN (see all proteins) (see all similar genes):
    KLRC3    KLRC1    KLRC4-KLRK1    KLRC4    FCER2    KLRF1
    KLRK1    CLEC1B    CLEC2D    SELP    REG1A    CLEC2L
    OLR1    KLRG1    CLEC4C    KLRD1    CLEC2B    CLEC5A

    KLRC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KLRC2
    PGOHUM00000237791


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    NKG2C_HUMAN, P26717: Two alleles are known. The sequence shown is that of allele NKG2-C*01


    Selected SNPs for KLRC2 (see all 255)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344725321,2
    C--10582710(+) ATTGTG/ACCTTC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs27344201,2
    C,F,A--10582739(-) GGCTAA/GGGTTT 1 -- ds50015Minor allele frequency- G:0.33NA CSA 9
    rs350601871,2
    --10582771(+) AACTAA/CGTTAT 1 -- ds50010--------
    rs581704541,2
    C,F--10582772(+) ACTAAG/ATTATA 1 -- ds50013Minor allele frequency- A:0.18WA 122
    rs348178011,2
    C--10582812(+) ATCATG/TTGCAG 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs355197611,2
    C--10582830(+) TGCTCG/ATTATA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs124258401,2
    C,H--10582879(+) ATTTAA/CATATA 1 -- ds50013Minor allele frequency- C:0.17NA WA EA 240
    rs348726421,2
    --10582997(+) TTACAA/GAAGCA 1 -- ds50010--------
    rs358874501,2
    C,F--10583061(+) TACAAG/TAGAGA 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1872806521,2
    --10583108(+) TTTATA/GCTGAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KLRC2 (10579453 - 10594899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KLRC2 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv190e201CNV Deletion23290073
    dgv263e199CNV Deletion23128226
    dgv264e199CNV Deletion23128226
    esv4003CNV Deletion18987735
    nsv435631CNV Deletion17901297
    esv2745535CNV Deletion23290073
    esv32543CNV Loss17666407
    esv8275CNV Loss19470904
    nsv898759CNV Loss21882294
    nsv898763CNV Loss21882294

    Human Gene Mutation Database (HGMD): KLRC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLRC2
    DNA2.0 Custom Variant and Variant Library Synthesis for KLRC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602891    OMIM disorders: --

    13 diseases for KLRC2:    
    About MalaCards
    paroxysmal nocturnal hemoglobinuria    stevens-johnson syndrome    toxic epidermal necrolysis    hemoglobinuria
    behcet's disease    eclampsia    pre-eclampsia    rheumatic disease
    cytomegalovirus infection    rheumatoid arthritis    arthritis    lupus erythematosus
    multiple sclerosis


    KLRC2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for KLRC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatic diseases 45.4 2 14688071 (1)
    lupus erythematosus systemic 26.1 3 14688071 (1), 12618865 (1)
    rheumatoid arthritis 15.8 3 14688071 (1), 12618865 (1)

    Genetic Association Database (GAD): KLRC2
    Human Genome Epidemiology (HuGE) Navigator: KLRC2 (5 documents)

    Export disorders for KLRC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KLRC2 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with KLRC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. (PubMed id 14688071)1, 4, 9 Miyashita R....Tokunaga K. (Int. Immunol. 2004)
    2. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PubMed id 12618865)1, 4, 9 Hikami K....Tokunaga K. (Genes Immun. 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis. (PubMed id 18700876)1, 4 Park K.S....Song Y.W. (Tissue Antigens 2008)
    5. Association of CD94/NKG2A, CD94/NKG2C, and its ligand HLA-E polymorphisms with Behcet's disease. (PubMed id 17767552)1, 4 Seo J....Park K.S. (Tissue Antigens 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PubMed id 11751968)1, 2 Shum B.P.... Parham P. (J. Immunol. 2002)
    8. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PubMed id 9683661)1, 2 Glienke J.... Francis F. (Immunogenetics 1998)
    9. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PubMed id 9598306)1, 3 Plougastel B. and Trowsdale J. (Genomics 1998)
    10. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PubMed id 2007850)1, 2 Houchins J.P.... Bach F.H. (J. Exp. Med. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3822 HGNC: 6375 AceView: KLRC1 Ensembl:ENSG00000205809 euGenes: HUgn3822
    ECgene: KLRC2 Kegg: 3822 H-InvDB: KLRC2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KLRC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLRC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLRC2 gene:
    Search GeneIP for patents involving KLRC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for KLRC2 (NKG2C/CD159c)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLRC2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KLRC2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KLRC2  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLRC2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KLRC2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLRC2   OriGene Custom Protein Services for KLRC2  

     
     
     Block miRNA regulation of human, mouse, rat KLRC2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLRC2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLRC2 Predesigned siRNA for gene silencing in human, mouse, rat KLRC2
     QuantiFast Probe-based Assays in human, mouse, rat KLRC2 QuantiTect SYBR Green Assays in human, mouse, rat KLRC2
     Custom PCR Arrays for KLRC2 Search Chromatin IP Primers for KLRC2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KLRC2  GeneGlobe Interaction Network for KLRC2
     Regulatory tfbs in KLRC2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KLRC2 GenScript cDNA clones with any tag delivered in your preferred vector for KLRC2
     GenScript Custom Assay Services for KLRC2 GenScript Custom overexpressing Cell Line Services for KLRC2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KLRC2 (NKG2C)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KLRC2 antibodies
     KLRC2 proteins
     KLRC2 lysates
     Antibodies for KLRC2
     See all of Abcam's Antibodies, Kits and Proteins for KLRC2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for KLRC2
     Proteins for KLRC2
     Antibodies for KLRC2
     ELISAs for KLRC2
     CLIAs for KLRC2



     Browse ESI BIO Cell Lines and PureStem Progenitors for KLRC2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2
     SwitchGear 3'UTR luciferase reporter plasmids for KLRC2
     SwitchGear Promoter luciferase reporter plasmids for KLRC2
     ThermoFisher Antibodies for KLRC2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLRC2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLRC2
     LSBio Antibodies in human, mouse, rat for KLRC2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLRC2 gene at Home site.
    Version: 3.12.158 12 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4