KLRC2 Gene
protein-coding GIFtS: 60
GCID: GC12M010583
|
|
killer cell lectin-like receptor subfamily C, member 2
| |
Aliases
for KLRC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Killer Cell Lectin-Like Receptor Subfamily C, Member 21 2 | | NK Cell Receptor C2 3 | | NKG2C2 3 5 | | NKG2-C-Activating NK Receptor2 3 | | CD159c1 2 | | NKG2-C Type II Integral Membrane Protein2 | | NKG2-C1 2 | | CD159c Antigen3 | | CD159 Antigen-Like Family Member C2 3 | | |
Export aliases for KLRC2 gene to outside databasesPrevious GC identifers: GC12P010266 GC12U900034 GC12M010484 GC12M010474 |
Summaries
for KLRC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLRC2:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cellswithout previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cellspreferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NKcell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes afamily of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and thepresence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region thatcontains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have beendescribed but their full-length nature has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxicT-cells
Gene Wiki entry for KLRC2
|
Genomic Views
for KLRC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLRC2 gene promoter:
Pax-3 AP-1 Bach2 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLRC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13KLRC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010583: view genomic region
(about GC identifiers)
Start:
|
10,579,453 bp from pter |
End:
|
10,594,899 bp from pter |
Size:
|
15,447 bases |
Orientation:
|
minus strand |
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Proteins
for KLRC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717 (See
protein sequence)Recommended Name: NKG2-C type II integral membrane protein Size: 231 amino acids; 26072 Da
Subunit: Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP
Subcellular location: Membrane; Single-pass type II membrane protein
1 PDB 3D structure from  and Proteopedia  for KLRC2:2L35 (3D)
Secondary accessions: O43802 Q52M74 Q9NR42Explore the universe of human proteins at neXtProt for KLRC2: NX_P26717
KLRC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002251.2
ENSEMBL proteins: ENSP00000438983 ENSP00000371327 ENSP00000444754 ENSP00000445240 ENSP00000371326 Reactome Protein details: P26717
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
TAS | 8436421 |
KLRC2 for ontologies About GeneDecksing
KLRC2 Antibody Products:
Assay Products for KLRC2: |
Protein
Domains /
Families
for KLRC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLRC2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P26717ProtoNet protein and cluster: P26717 UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717Similarity: Contains 1 C-type lectin domain |
Function
for KLRC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxicT-cells Genatlas biochemistry entry for KLRC2:natural killer cell lectin-like receptor subfamily C,member 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
KLRC2 for ontologies About GeneDecksing
|
Pathways & Interactions
for KLRC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Signaling by FGFR | | | 3 | Immune response CD16 signaling in NK cells | | | 4 | Natural killer cell mediated cytotoxicity | | | 5 | Allograft rejection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KLRC2
1  GeneGo (Thomson Reuters) Pathway for KLRC2
4 
Reactome Pathways for KLRC2
2 
Kegg Pathways (Kegg details for KLRC2):
KLRC2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLRC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for KLRC2 (P267171, 3 ENSP000003713274) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
KLRC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLRC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLRC2
Search CenterWatch for drugs/clinical trials and news about KLRC2 / NKG2C
|
Transcripts
for KLRC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLRC2 gene: NM_002260.3 Unigene Cluster for KLRC2: Killer cell lectin-like receptor subfamily C, member 2 Hs.591157 [show with all ESTs]Unigene Representative Sequence: NM_0022605 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000535069 ENST00000381902(uc010she.1 uc001qyk.2) ENST00000536833
ENST00000537017 ENST00000381901
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLRC2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLRC2 (NM_002260) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLRC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2 |
Additional cDNA sequence: AF260134.1 AK295525.1 BC093644.1 BC106069.1 BC112039.1 X54869.1 Y13055.1 4 DOTS entries: DT.100783358 DT.75132896 DT.121197028 DT.91722289 24/53 AceView cDNA sequences (see all 53): AA190627 NM_213657 AF260134 X54867 NM_213658 BC053840 NM_007328 X54868 AA191156 NM_002259 AA913480 BX330986 Y13055 BX282341 CD639096 BG057689 BG218887 AF461812 CA396224 BC012550 BI335443 BX350415 BX280271 NM_002260
GeneLoc Exon Structure
|
Expression
for KLRC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLRC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTTCAAT
About this image
See KLRC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLRC2
SOURCE GeneReport for Unigene cluster: Hs.591157
UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717Tissue specificity: Natural killer cells
SABiosciences Custom PCR Arrays for KLRC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLRC2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat KLRC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2 |
Orthologs
for KLRC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLRC2 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CLEC9A6 |
-- |
27(a) |
1 → many |
2(81818136-81823316) |
ENSEMBL Gene Tree for KLRC2 (if available)
TreeFam Gene Tree for KLRC2 (if available) |
Paralogs
for KLRC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLRC2 gene
- OLR12 CLEC9A2 ENSG000002558192 CLEC12A2 CLEC1A2 KLRC32 KLRD12 KLRK12
- KLRC42 CLEC1B2 ENSG000002556412 CLEC7A2 KLRC12 CLEC12B2
17 SIMAP similar genes for KLRC2 using alignment to 6 protein entries: NKG2C_HUMAN (see all proteins):KLRC3 KLRC1 KLRC4 KLRK1 FCER2 KLRF1
CLEC1B CLEC2D REG1A CLEC2L OLR1 KLRG1
CLEC4C KLRD1 CLEC2B CLEC5A CLEC10A
KLRC2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KLRC2
PGOHUM00000237791
|
Genomic Variants
for KLRC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: NKG2C_HUMAN, P26717Polymorphism: Two alleles are known. The sequence shown is that of allele NKG2-C*01
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLRC2 (10579453 - 10594899 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for KLRC2
13 CNVs: 31857 86209 38028 23207 61206 35038 86210 43682 66137 6959 35037 86208 35036 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRC2 |
|
Disorders
/ Diseases
for KLRC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLRC2 for disorders About GeneDecksing
OMIM gene information: 602891
OMIM disorders: --
10  diseases for KLRC2: About MalaCardsparoxysmal nocturnal hemoglobinuria toxic epidermal necrolysis stevens-johnson syndrome pre-eclampsia
hemoglobinuria lupus erythematosus rheumatoid arthritis behcet's disease
eclampsia arthritis
3 Novoseek disease relationships for KLRC2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rheumatic diseases |
45.4 |
2 |
14688071 (1) |
| lupus erythematosus systemic |
26.1 |
3 |
14688071 (1), 12618865 (1) |
| rheumatoid arthritis |
15.8 |
3 |
14688071 (1), 12618865 (1) |
Genetic Association Database (GAD): KLRC2
Human Genome Epidemiology (HuGE) Navigator: KLRC2 (5 documents)
Export disorders for KLRC2 gene to outside databases
|
Publications
for KLRC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLRC2 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with KLRC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. (PubMed id 14688071)1, 4, 9 Miyashita R....Tokunaga K. (2004)
- Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PubMed id 12618865)1, 4, 9 Hikami K....Tokunaga K. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PubMed id 11751968)1, 2 Shum B.P.... Parham P. (2002)
- The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PubMed id 9683661)1, 2 Glienke J.... Francis F. (1998)
- Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PubMed id 9598306)1, 3 Plougastel B. and Trowsdale J. (1998)
- DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PubMed id 2007850)1, 2 Houchins J.P....Bach F.H. (1991)
- Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses. (PubMed id 15550116)1, 9 Ortega C....Santamaria M. (2004)
- Association of DAP12 with activating CD94/NKG2C NK cell receptors. (PubMed id 9655483)1, 9 Lanier L.L....Phillips J.H. (1998)
- Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. (PubMed id 8943374)1, 9 Lazetic S....Phillips J.H. (1996)
|
External Searches for KLRC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLRC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLRC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLRC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KLRC2 gene:
Search GeneIP for patents involving KLRC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLRC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLRC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLRC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLRC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLRC2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRC2 |
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