Aliases for KLRC1 Gene
External Ids for KLRC1 Gene
Previous Symbols for KLRC1 Gene
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
GeneCards Summary for KLRC1 Gene
KLRC1 (Killer Cell Lectin-Like Receptor Subfamily C, Member 1) is a Protein Coding gene. Diseases associated with KLRC1 include malaria. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is KLRK1.
UniProtKB/Swiss-Prot for KLRC1 Gene
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells