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KLRC1 Gene

protein-coding   GIFtS: 62
GCID: GC12M010708

Killer Cell Lectin-Like Receptor Subfamily C, Member 1


(Previous symbol: NKG2)
  See KLRC1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Lectin-Like Receptor Subfamily C, Member 11 2     CD159A2
NKG21 2 5     C-Lectin Type II Protein2
NKG2A2 3 5     Natural Killer Cell Lectin2
NKG2-1/B Activating NK Receptor1 2     Natural Killer Group Protein 22
CD159 Antigen-Like Family Member A2 3     NKG2-A/B Type II Integral Membrane Protein2
NK Cell Receptor A2 3     NKG2-A/NKG2-B Type II Integral Membrane Protein2
NKG2-A/B-Activating NK Receptor2 3     CD159a Antigen3

External Ids:    HGNC: 63741   Entrez Gene: 38212   Ensembl: ENSG000001345457   OMIM: 1615555   UniProtKB: P267153   

Export aliases for KLRC1 gene to outside databases

Previous GC identifers: GC12M010302 GC12M010712 GC12M010483 GC12M010489 GC12M010598 GC12M010325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLRC1 Gene:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells
without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein
encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a
group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by
the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with
another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules
in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome
12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. (provided
by RefSeq, Jul 2008)

GeneCards Summary for KLRC1 Gene:
KLRC1 (killer cell lectin-like receptor subfamily C, member 1) is a protein-coding gene. Diseases associated with KLRC1 include malaria. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is KLRC2.

UniProtKB/Swiss-Prot: NKG2A_HUMAN, P26715
Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
cytotoxic T-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLRC1 gene promoter:
         Pax-3   FOXF2   AML1a   Bach2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRC1 promoter sequence
   Search Chromatin IP Primers for KLRC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

KLRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010708:  view genomic region     (about GC identifiers)

Start:
10,594,863 bp from pter      End:
10,607,284 bp from pter
Size:
12,422 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NKG2A_HUMAN, P26715 (See protein sequence)
Recommended Name: NKG2-A/NKG2-B type II integral membrane protein  
Size: 233 amino acids; 26314 Da
Subunit: Can form disulfide-bonded heterodimer with CD94
5 PDB 3D structures from and Proteopedia for KLRC1:
2RMX (3D)        2YU7 (3D)        3BDW (3D)        3CDG (3D)        3CII (3D)    
Alternative splicing: 2 isoforms:  P26715-1   P26715-2   

Explore the universe of human proteins at neXtProt for KLRC1: NX_P26715

Explore proteomics data for KLRC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn102, Asn103, Asn151, Asn180
  • Modification sites at PhosphoSitePlus

  • See KLRC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_002250.1  NP_015567.1  NP_998822.1  NP_998823.1  

    ENSEMBL proteins: 
     ENSP00000441432   ENSP00000352064   ENSP00000385304   ENSP00000256965   ENSP00000442545  
     ENSP00000438038  
    Reactome Protein details: P26715

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLR: Killer cell lectin-like receptors
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P26715

    ProtoNet protein and cluster: P26715

    UniProtKB/Swiss-Prot: NKG2A_HUMAN, P26715
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with KLRC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKG2A_HUMAN, P26715
    Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some
    cytotoxic T-cells

         Genatlas biochemistry entry for KLRC1:
    natural killer cell lectin-like receptor subfamily C,member 1 with two alternatively spliced isoforms A (NKG2A),B
    (NKG2B)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS2007850
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with KLRC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLRC1:
     Synthetic lethal with c-Myc af 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NKG2A_HUMAN, P26715: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2007850

    Find genes that share ontologies with KLRC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLRC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.33
    2Allograft rejection
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    5Immune response Role of integrins in NK cells cytotoxicity
    Immune response Role of integrins in NK cells cytotoxicity


    Find genes that share SuperPaths with KLRC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for KLRC1
        Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells
    Immune response Role of integrins in NK cells cytotoxicity


    1 Reactome Pathway for KLRC1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    3 Kegg Pathways  (Kegg details for KLRC1):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease

        Pathway & Disease-focused RT2 Profiler PCR Array including KLRC1: 
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLRC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for KLRC1 (P267153 ENSP000003520644) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206493P137473, ENSP000003730914I2D: score=1 STRING: ENSP00000373091
    ENSG00000229252P137473, ENSP000004099104I2D: score=1 STRING: ENSP00000409910
    HLA-EP137473, ENSP000003658174I2D: score=1 STRING: ENSP00000365817
    ENSG00000230254P137473I2D: score=1 
    ENSG00000233904P137473I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS2007850
    GO:0050776regulation of immune response TAS--

    Find genes that share ontologies with KLRC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLRC1 (NKG2A)

    2 Novoseek inferred chemical compound relationships for KLRC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    toxin-1 53.2 1 15550116 (1)
    tyrosine 0 15 9485206 (2), 16237464 (1)



    Find genes that share compounds with KLRC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLRC1 gene (4 alternative transcripts): 
    NM_002259.4  NM_007328.3  NM_213657.2  NM_213658.2  

    Unigene Cluster for KLRC1:

    Killer cell lectin-like receptor subfamily C, member 1
    Hs.512576  [show with all ESTs]
    Unigene Representative Sequence: NM_213658
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536188(uc009zhm.2) ENST00000359151(uc001qyl.3 uc001qym.3)
    ENST00000408006(uc001qyo.3) ENST00000347831 ENST00000543893 ENST00000537699
    ENST00000544822(uc001qyn.3)
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    Additional mRNA sequence: 

    AF461812.1 AK310992.1 BC012550.1 BC053840.1 X54867.1 X54868.1 

    5 DOTS entries:

    DT.91961321  DT.95373141  DT.97768159  DT.91757663  DT.99987361 

    Selected AceView cDNA sequences (see all 53):

    NM_213657 X54867 NM_213658 AA191156 NM_007328 NM_002259 BC053840 AF260134 
    X54868 AA190627 BX280271 BF529720 AF461812 AI798774 BC012550 N68872 
    BI335443 CD639096 BX282341 BG218887 BX330986 BX350415 X54869 BG057689 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KLRC1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -     -           -                 -                           
    SP2:              -     -           -                 -     -                     
    SP3:                                -                 -                           
    SP4:                                -                 -     -                     
    SP5:                                                                              


    ECgene alternative splicing isoforms for KLRC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLRC1 Expression
    About this image


    KLRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Spleen (Hematopoietic System)
    KLRC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLRC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512576

    UniProtKB/Swiss-Prot: NKG2A_HUMAN, P26715
    Tissue specificity: Natural killer cells

        Pathway & Disease-focused RT2 Profiler PCR Array including KLRC1: 
              Cell Surface Markers in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLRC1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrc11 , 5 killer cell lectin-like receptor subfamily C, member more1, 5 65.95(n)1
    44.4(a)1
      6 (63.44 cM)5
    166411  NM_001136068.11  NP_001129540.11 
     1296660155 


    ENSEMBL Gene Tree for KLRC1 (if available)
    TreeFam Gene Tree for KLRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLRC1 gene
    KLRC22  KLRD12  KLRK12  KLRC42  KLRC4-KLRK12  ENSG000002556412  KLRC32  
    18 SIMAP similar genes for KLRC1 using alignment to 4 protein entries:     NKG2A_HUMAN (see all proteins):
    KLRC4-KLRK1    KLRC2    KLRC3    KLRC4    FCER2    KLRF1
    CLEC1B    CLEC2D    KLRD1    OLR1    ASGR1    KLRG1
    CLEC2L    CLEC4C    REG1A    CLEC10A    KLRK1    CLEC2B

    Find genes that share paralogs with KLRC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLRC1 (see all 347)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828675551,2
    --10471154(+) ATTGTA/GCCTTC 2 -- ds50010--------
    rs1870178051,2
    --10471167(+) TTCAAC/GTATGG 2 -- ds50010--------
    rs1915511421,2
    --10471242(+) AAATAA/GAAGTG 2 -- ds50010--------
    rs619177181,2
    C,F--10471245(+) TAAAAG/CTGTGA 2 -- ds50013Minor allele frequency- C:0.17NA WA 240
    rs1837081031,2
    --10471255(+) ATCATA/GTGCAG 2 -- ds50010--------
    rs45424951,2
    C,F,A,H--10471273(+) TGCTCG/ATTATA 2 -- ds50011Minor allele frequency- A:0.21NS 116
    rs1876990201,2
    --10471322(+) ATTTAA/CATATA 2 -- ds50010--------
    rs44928991,2
    C,A,H--10471440(+) TTACAA/GAAGCA 2 -- ds50010--------
    rs1132297711,2
    C,F--10471504(+) TACAAG/TAGAGA 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1857223811,2
    --10471548(+) CACTTC/TATATT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for KLRC1 (10594863 - 10607284 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KLRC1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv190e201CNV Deletion23290073
    dgv264e199CNV Deletion23128226
    nsv606CNV Loss18451855
    esv32543CNV Loss17666407
    esv25005CNV Loss19812545
    dgv1371n71CNV Loss21882294
    nsv8914CNV Loss18304495
    dgv1372n71CNV Loss21882294
    nsv898763CNV Loss21882294
    dgv270n67CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLRC1
    DNA2.0 Custom Variant and Variant Library Synthesis for KLRC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 161555    OMIM disorders: --

    1 disease for KLRC1:    
    About MalaCards
    malaria


    Find genes that share disorders with KLRC1           About GenesLikeMe

    7 Novoseek inferred disease relationships for KLRC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    toxic shock syndrome 42.1 1 15550116 (1)
    lymphoma t-cell 15.4 2 10828054 (1)
    cancer 5.03 1 15805295 (1)
    necrosis 0 2 11493613 (1)
    aids 0 1 18172398 (1)
    tumors 0 4 11169413 (1), 11493613 (1), 17202324 (1)
    lymphoma 0 1 11337356 (1)

    Genetic Association Database (GAD): KLRC1
    Human Genome Epidemiology (HuGE) Navigator: KLRC1 (8 documents)

    Export disorders for KLRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KLRC1 gene, integrated from 10 sources (see all 151):
    (articles sorted by number of sources associating them with KLRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PubMed id 9598306)1, 2, 3, 9 Plougastel B. and Trowsdale J. (Genomics 1998)
    2. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PubMed id 12618865)1, 4, 9 Hikami K....Tokunaga K. (Genes Immun. 2003)
    3. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. (PubMed id 2007850)1, 2, 9 Houchins J.P.... Bach F.H. (J. Exp. Med. 1991)
    4. CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. (PubMed id 18332182)1, 2, 9 Petrie E.J.... Rossjohn J. (J. Exp. Med. 2008)
    5. Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene. (PubMed id 8753859)1, 2, 9 Plougastel B.... Trowsdale J. (Immunogenetics 1996)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population. (PubMed id 20648603)1, 4 Ma J....Liu Y. (J. Med. Virol. 2010)
    8. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    9. Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis. (PubMed id 18700876)1, 4 Park K.S....Song Y.W. (Tissue Antigens 2008)
    10. Structural basis for NKG2A/CD94 recognition of HLA-E. (PubMed id 18448674)1, 2 Kaiser B.K.... Strong R.K. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3821 HGNC: 6374 AceView: KLRC1 Ensembl:ENSG00000134545 euGenes: HUgn3821
    ECgene: KLRC1 Kegg: 3821 H-InvDB: KLRC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLRC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLRC1 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_245

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLRC1 gene:
    Search GeneIP for patents involving KLRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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