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KLRB1 Gene

protein-coding   GIFtS: 61
GCID: GC12M010497

Killer Cell Lectin-Like Receptor Subfamily B, Member 1


(Previous symbol: NKR)
  See KLRB1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Lectin-Like Receptor Subfamily B, Member 11 2     CD1612
NKRP1A2 3 5     NKR-P12
NKR1 2     hNKR-P1A2
Natural Killer Cell Surface Protein P1A2 3     Killer Cell Lectin-Like Receptor Subfamily B Member 12
CLEC5B2 3     HNKR-P1a3
NKR-P1A2 3     CD161 Antigen3
C-Type Lectin Domain Family 5 Member B2 3     

External Ids:    HGNC: 63731   Entrez Gene: 38202   Ensembl: ENSG000001117967   OMIM: 6028905   UniProtKB: Q129183   

Export aliases for KLRB1 gene to outside databases

Previous GC identifers: GC12M009430 GC12M009870 GC12M009647 GC12M009638 GC12M009490 GC12M009748 GC12M009837 GC12M010061 GC12M010255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLRB1 Gene:
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune
stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins,
are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains
an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a
cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C
terminus. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLRB1 Gene:
KLRB1 (killer cell lectin-like receptor subfamily B, member 1) is a protein-coding gene. Diseases associated with KLRB1 include cytomegalovirus infection. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLECL1.

UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918
Function: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid
sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also
leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced
by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the
N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as
well as interferon-gamma secretion in target cells

Gene Wiki entry for KLRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLRB1 gene promoter:
         AML1a   POU3F2   NF-AT   PPAR-alpha   NF-AT4   POU2F1   NF-AT2   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLRB1 promoter sequence
   Search Chromatin IP Primers for KLRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

KLRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRB1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010497:  view genomic region     (about GC identifiers)

Start:
9,747,147 bp from pter      End:
9,760,497 bp from pter
Size:
13,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918 (See protein sequence)
Recommended Name: Killer cell lectin-like receptor subfamily B member 1  
Size: 225 amino acids; 25415 Da
Subunit: Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1
Secondary accessions: Q24K24

Explore the universe of human proteins at neXtProt for KLRB1: NX_Q12918

Explore proteomics data for KLRB1 at MOPED

Post-translational modifications: 

  • N-glycosylated. Contains sialic acid residues1
  • Glycosylation2 at Asn157

  • See KLRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002249.1  
    ENSEMBL proteins: 
     ENSP00000229402  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLR: Killer cell lectin-like receptors
    CD: CD molecules
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q12918

    ProtoNet protein and cluster: Q12918

    UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with KLRB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLRB1_HUMAN, Q12918
    Function: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid
    sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also
    leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced
    by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the
    N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as
    well as interferon-gamma secretion in target cells
    Induction: By IL12/interleukin-12 in NK cells

         Genatlas biochemistry entry for KLRB1:
    natural killer cell lectin-like receptor subfamily B,member 1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS8077657
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with KLRB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLRB1:
     Increased cell number in G1, a 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLRB1_HUMAN, Q12918: Membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS8077657
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with KLRB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLRB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Malaria
    Malaria


    Find genes that share SuperPaths with KLRB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for KLRB1):
        Malaria

        Pathway & Disease-focused RT2 Profiler PCR Array including KLRB1: 
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLRB1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KLRB1 (Q129183 ENSP000002294024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLEC2DQ9UHP73, ENSP000002613404I2D: score=1 STRING: ENSP00000261340
    PTPN6P293503, ENSP000003915924I2D: score=2 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS8077657

    Find genes that share ontologies with KLRB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLRB1

    Selected HMDB Compounds for KLRB1 (see all 111)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
    3-O-Sulfogalactosylceramide (d18:1/26:1(17Z))Sulfatide (d18:1/26:1(17Z)) (see all 13)928346-40-1--

    3 Novoseek inferred chemical compound relationships for KLRB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-galactosylceramide 66.7 2 10692041 (1)
    calcium 0 2 7887967 (1), 9394825 (1)
    tyrosine 0 1 9211750 (1)



    Find genes that share compounds with KLRB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLRB1 gene: 
    NM_002258.2  

    Unigene Cluster for KLRB1:

    Killer cell lectin-like receptor subfamily B, member 1
    Hs.169824  [show with all ESTs]
    Unigene Representative Sequence: BC027885
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229402(uc010sgt.2)
    miRNA
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    Additional mRNA sequence: 

    AK292022.1 BC027885.1 BC113997.1 BC114516.1 U11276.1 

    2 DOTS entries:

    DT.308363  DT.106846 

    Selected AceView cDNA sequences (see all 32):

    BX116375 AW205651 BF432813 AI796728 CF541066 CF541109 AI130829 AI690028 
    BF110796 BC027885 AA195023 AW612744 AI924973 W93811 CD641191 NM_002258 
    AW135677 U11276 AI340224 BI838824 AA195152 AI377364 AA194956 AI707618 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCAACAAG
    KLRB1 Expression
    About this image


    KLRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    KLRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169824

    UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918
    Tissue specificity: Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected
    in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype

        Pathway & Disease-focused RT2 Profiler PCR Array including KLRB1: 
              Cell Surface Markers in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLRB1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klrb15
    Klrb1a1
    killer cell lectin-like receptor subfamily B member more1, 5 66.36(n)1
    48.6(a)1
      6 (63.08 cM)5
    170571  NM_010737.31  NP_034867.31 
     1287065085 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    26(a)
    26(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    2(193323692-193346185)
    GL343945.1(108972-121566)


    ENSEMBL Gene Tree for KLRB1 (if available)
    TreeFam Gene Tree for KLRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLRB1 gene
    CLECL12  KLRF22  KLRF12  
    1 SIMAP similar gene for KLRB1 using alignment to 1 protein entry:     KLRB1_HUMAN:
    CLEC2B

    Find genes that share paralogs with KLRB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLRB1 (see all 452)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677126801,2
    C--9625877(+) GTGGT-/A/AAA 
            
    AAAAA
    1 -- int11NA 2
    rs1496141111,2
    --9747374(+) AATAGA/GTGAAA 1 -- ds50010--------
    rs1869045821,2
    --9747450(+) TAAGAA/GCTATT 1 -- ds50010--------
    rs20584291,2
    C,F,A,H--9747466(-) CATACG/AAGGGC 1 -- ds5001 ese3110Minor allele frequency- A:0.17NS MN EA PA EU CA WA NA CSA 6968
    rs20584281,2
    C,F,H--9747513(-) CCGCAT/CGCGGC 1 -- ds5001 ese39Minor allele frequency- C:0.19WA NA CSA 16
    rs20584271,2
    C,F,A,H--9747557(-) GGAGAT/AATTGT 1 -- ds500199Minor allele frequency- A:0.46NS EA PA EU CA WA NA CSA 4894
    rs1445168151,2
    --9747580(+) ACAAAA/GCAATC 1 -- ds50010--------
    rs1379292491,2
    --9747646(+) ACTGTG/TTCTTT 1 -- ds50010--------
    rs1917377381,2
    --9747648(+) TGTTTA/CTTTAA 1 -- ds50010--------
    rs20584261,2
    C,F,A,H--9747676(-) AGAGAC/TATAGA 1 -- ds500124Minor allele frequency- T:0.47NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for KLRB1 (9747147 - 9760497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KLRB1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv603CNV Insertion18451855
    nsv898754CNV Loss21882294
    dgv1369n71CNV Loss21882294
    nsv602CNV Loss18451855
    nsv8909CNV Gain18304495
    nsv428271CNV Gain18775914
    essv5635CNV CNV17122850
    essv6453CNV CNV17122850
    dgv466e1CNV Complex17122850
    dgv471e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLRB1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602890    OMIM disorders: --

    1 disease for KLRB1:    
    About MalaCards
    cytomegalovirus infection


    Find genes that share disorders with KLRB1           About GenesLikeMe

    6 Novoseek inferred disease relationships for KLRB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell 31.4 2 10828054 (1)
    autoimmune diseases 21 3 18706662 (1), 11978777 (1)
    tumors 0 8 17145807 (3), 18159636 (1), 12894845 (1), 15259008 (1)
    lymphoma 0 4 11025592 (2)
    melanoma 0 2 15889254 (1), 10382762 (1)
    cancer 0 13 17145807 (4), 18159636 (3), 17927817 (1), 12894845 (1) (see all 6)

    Genetic Association Database (GAD): KLRB1
    Human Genome Epidemiology (HuGE) Navigator: KLRB1 (4 documents)

    Export disorders for KLRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KLRB1 gene, integrated from 10 sources (see all 115):
    (articles sorted by number of sources associating them with KLRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. (PubMed id 8077657)1, 2, 3, 9 Lanier L.L.... Phillips J.H. (J. Immunol. 1994)
    2. IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation. (PubMed id 9603467)1, 2, 9 Poggi A.... Moretta L. (Eur. J. Immunol. 1998)
    3. Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161). (PubMed id 16925668)1, 2, 9 Christiansen D....Sandrin M.S. (Xenotransplantation 2006)
    4. Lectin-like transcript 1 is a ligand for the CD161 receptor. (PubMed id 16339512)1, 2, 9 Aldemir H.... Braud V.M. (J. Immunol. 2005)
    5. Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis. (PubMed id 19834503)1, 4 Hoppenbrouwers I.A....Hintzen R.Q. (J. Hum. Genet. 2009)
    6. Risk alleles for multiple sclerosis in multiplex families. (PubMed id 19506219)1, 4 D'Netto M.J....Ebers G.C. (Neurology 2009)
    7. CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase. (PubMed id 16455998)1, 2 Pozo D....Reyburn H. (J. Immunol. 2006)
    8. Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. (PubMed id 16339513)1, 2 Rosen D.B....Lanier L.L. (J. Immunol. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver. (PubMed id 12100027)1, 2 Iiai T.... Hatakeyama K. (Clin. Exp. Immunol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3820 HGNC: 6373 AceView: KLRB1 Ensembl:ENSG00000111796 euGenes: HUgn3820
    ECgene: KLRB1 Kegg: 3820 H-InvDB: KLRB1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLRB1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_248

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLRB1 gene:
    Search GeneIP for patents involving KLRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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