KLRB1 Gene
protein-coding GIFtS: 59
GCID: GC12M010061
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|
killer cell lectin-like receptor subfamily B, member 1
(Previous symbol: NKR)
| |
Aliases
for KLRB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Killer Cell Lectin-Like Receptor Subfamily B, Member 11 2 | | HNKR-P1A1 | | CLEC5B1 2 3 | | Natural Killer Cell Surface Protein P1A2 3 | | NKR-P1A1 2 3 | | C-Type Lectin Domain Family 5 Member B2 3 | | NKRP1A2 3 5 | | Killer Cell Lectin-Like Receptor Subfamily B Member 12 | | CD1611 2 | | HNKR-P1a3 | | NKR1 2 | | CD161 Antigen3 | | NKR-P11 2 | | |
Export aliases for KLRB1 gene to outside databasesPrevious GC identifers: GC12M009430 GC12M009870 GC12M009647 GC12M009638 GC12M009490 GC12M009748 GC12M009837 |
Summaries
for KLRB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLRB1:
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation.Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed byNK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domainwith several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1protein is classified as a type II membrane protein because it has an external C terminus. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918Function: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acidsphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leadsto AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced byanti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to theN-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as wellas interferon-gamma secretion in target cells
Gene Wiki entry for KLRB1
|
Genomic Views
for KLRB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLRB1 gene promoter:
AML1a POU3F2 NF-AT PPAR-alpha NF-AT4 POU2F1 NF-AT2 POU2F1a NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLRB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13KLRB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010061: view genomic region
(about GC identifiers)
Start:
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9,747,147 bp from pter |
End:
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9,760,497 bp from pter |
Size:
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13,351 bases |
Orientation:
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minus strand |
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Proteins
for KLRB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918 (See
protein sequence)Recommended Name: Killer cell lectin-like receptor subfamily B member 1 Size: 225 amino acids; 25415 Da
Subunit: Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: Q24K24Explore the universe of human proteins at neXtProt for KLRB1: NX_Q12918
Post-translational modifications:
N-glycosylated. Contains sialic acid residues1
View neXtProt modification sites for NX_Q12918
KLRB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002249.1
ENSEMBL proteins: ENSP00000229402
Human Recombinant Protein Products for KLRB1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KLRB1 for ontologies About GeneDecksing
KLRB1 Antibody Products:
Assay Products for KLRB1: |
Protein
Domains /
Families
for KLRB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLRB1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q12918ProtoNet protein and cluster: Q12918 UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918Similarity: Contains 1 C-type lectin domain |
Function
for KLRB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KLRB1_HUMAN, Q12918Function: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acidsphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leadsto AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced byanti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to theN-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as wellas interferon-gamma secretion in target cellsInduction: By IL12/interleukin-12 in NK cells Genatlas biochemistry entry for KLRB1:natural killer cell lectin-like receptor subfamily B,member 1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004888 | transmembrane signaling receptor activity |
TAS | 8077657 | | GO:0030246 | carbohydrate binding |
IEA | -- |
KLRB1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for KLRB1:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRB1 |
|
Pathways & Interactions
for KLRB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Malaria | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for KLRB1):
KLRB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLRB1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KLRB1 (Q129183 ENSP000002294024) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007166 | cell surface receptor signaling pathway |
TAS | 8077657 |
KLRB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLRB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KLRB1 for compounds About GeneDecksing
 Browse Tocris compounds for KLRB1
10/111 HMDB Compounds for KLRB1 (see all 111) About this table
3 Novoseek chemical compound relationships for KLRB1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alpha-galactosylceramide |
66.7 |
2 |
10692041 (1) |
| calcium |
0 |
2 |
7887967 (1), 9394825 (1) |
| tyrosine |
0 |
1 |
9211750 (1) |
Search CenterWatch for drugs/clinical trials and news about KLRB1
|
Transcripts
for KLRB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLRB1 gene: NM_002258.2 Unigene Cluster for KLRB1: Killer cell lectin-like receptor subfamily B, member 1 Hs.169824 [show with all ESTs]Unigene Representative Sequence: BC0278851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000229402(uc010sgt.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLRB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLRB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLRB1 (NM_002258) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLRB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLRB1 |
Additional cDNA sequence: AK292022.1 BC027885.1 BC113997.1 BC114516.1 U11276.1 2 DOTS entries: DT.308363 DT.106846 24/32 AceView cDNA sequences (see all 32): AW205651 BF432813 BX116375 AI796728 CF541109 CF541066 AI130829 NM_002258 AW135677 BI838824 AA195023 AI924973 BF110796 CD641191 AW612744 AA195152 AI690028 AI340224 W93811 U11276 BC027885 AI707618 AA194956 CD690592
GeneLoc Exon Structure
|
Expression
for KLRB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLRB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCAACAAG
About this image
See KLRB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLRB1
SOURCE GeneReport for Unigene cluster: Hs.169824
UniProtKB/Swiss-Prot: KLRB1_HUMAN, Q12918Tissue specificity: Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected inperipheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype
SABiosciences Expression via Pathway-Focused PCR Array including KLRB1: | Cell Surface Markers in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLRB1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLRB1 |
Orthologs
for KLRB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for KLRB1 (if available)
TreeFam Gene Tree for KLRB1 (if available) |
Paralogs
for KLRB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLRB1 gene
- CLEC2A2 CLEC2L2 CLEC2B2 KLRF22 KLRG22 CD692 CLEC2D2 CLEC5A2
- KLRF12 KLRG12
1 SIMAP similar gene for KLRB1 using alignment to 1 protein entry: KLRB1_HUMAN:CLEC2B
KLRB1 for paralogs About GeneDecksing
|
Genomic Variants
for KLRB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLRB1 (9747147 - 9760497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KLRB1
3 CNVs: 2970 3874 30585 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLRB1 |
|
Disorders
/ Diseases
for KLRB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLRB1 for disorders About GeneDecksing
OMIM gene information: 602890
OMIM disorders: --
20/23  diseases for KLRB1 (see all 23): About MalaCardstype 1 diabetes mellitus reactive arthritis cytomegalovirus infection diabetes mellitus
acute myeloid leukemia myeloid leukemia celiac disease graves' disease
rheumatoid arthritis multiple sclerosis hepatitis c hepatitis b
arthritis cervical carcinoma cervicitis hepatitis
psoriasis colorectal cancer leukemia melanoma
6 Novoseek disease relationships for KLRB1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: KLRB1 (4 documents)
Export disorders for KLRB1 gene to outside databases
|
Publications
for KLRB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLRB1 gene, integrated from 9 sources (see all 113):
(articles sorted by number of sources associating them with KLRB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. (PubMed id 8077657)1, 2, 3, 9 Lanier L.L.... Phillips J.H. (1994)
- IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation. (PubMed id 9603467)1, 2, 9 Poggi A.... Moretta L. (1998)
- Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161). (PubMed id 16925668)1, 2, 9 Christiansen D....Sandrin M.S. (2006)
- Lectin-like transcript 1 is a ligand for the CD161 receptor. (PubMed id 16339512)1, 2, 9 Aldemir H.... Braud V.M. (2005)
- CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase. (PubMed id 16455998)1, 2 Pozo D....Reyburn H. (2006)
- Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. (PubMed id 16339513)1, 2 Rosen D.B....Lanier L.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver. (PubMed id 12100027)1, 2 Iiai T.... Hatakeyama K. (2002)
- Expression and function of NKRP1A molecule on human monocytes and dendritic cells. (PubMed id 9394825)1, 9 Poggi A....Zocchi M.R. (1997)
- [Transcription of the KLRB1 gene is suppressed in human cancer tissues] (PubMed id 18159636)1, 9 Pleshkan V.V....Sverdlov E.D. (2007)
|
External Searches for KLRB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLRB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLRB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLRB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLRB1 | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_248 |
|
| | |
About This Section
| Patent Information for KLRB1 gene:
Search GeneIP for patents involving KLRB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLRB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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