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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLRAP1 Gene

pseudogene   GIFtS: 37
GCID: GC12M010744

killer cell lectin-like receptor subfamily A pseudogene...

(Previous names: killer cell lectin-like receptor subfamily A, member 1...)
(Previous symbol: KLRA1)
 Explore 4 diseases affiliated with
KLRAP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLRAP1    

Aliases
for KLRAP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
Killer Cell Lectin-Like Receptor Subfamily A Pseudogene 11 2     Killer Cell Lectin-Like Receptor Subfamily A, Member 11
KLRA11 2 5     KLRA#2
LY49L1 2 5     Ly-49L2
Ly491 2     

External Ids:    HGNC: 63721   Entrez Gene: 107482   Ensembl: ENSG000002566677   OMIM: 6042745   
ORGUL members:         
NONCODE:n373467 n346211 n386040 n386039 n372903    

Export aliases for KLRAP1 gene to outside databases


Summaries
for KLRAP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for KLRAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KLRAP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLRAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLRAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLRAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

KLRAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLRAP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010744:  view genomic region     (about GC identifiers)

Start:
 10,741,077 bp from pter      End:
 10,752,434 bp from pter
Size:
 11,358 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for KLRAP1

Proteins
for KLRAP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
Post-translational modifications:
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_

    • KLRAP1 Protein expression data from MOPED and PaxDb: --

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    Protein Domains /
    Families
    for KLRAP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		   --

    Function
    for KLRAP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Animal Models:
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    Pathways & Interactions
    for KLRAP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response CD16 signaling in NK cells
    		Immune response_Role of DAP12 receptors in NK cells0.32
    		Immune response Role of DAP12 receptors in NK cells0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KLRAP1
        Immune response Role of DAP12 receptors in NK cells


    1 GeneGo (Thomson Reuters) Pathway for KLRAP1
        Immune response Role of DAP12 receptors in NK cells



    KLRAP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLRAP1

    Drugs & Compounds
    for KLRAP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about KLRAP1 

    Transcripts
    for KLRAP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for KLRAP1 gene: 
    NM_006611.2  

    Unigene Cluster for KLRAP1:

    Killer cell lectin-like receptor subfamily A pseudogene 1
    Hs.159297  [show with all ESTs]
    Unigene Representative Sequence: NR_028045
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510134 ENST00000535939 ENST00000503499 ENST00000341141(uc010shf.2 uc010shg.2 uc009zho.3 uc009zhn.3)
    ENST00000521068

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF047445.1 AK290077.1 AK296103.1 AK304677.1 AK310151.1 AY334570.1 BC069672.1 BC069697.1 
    BC069734.1 BC101471.1 BC101473.1 NR_028045.1 

    4 DOTS entries:

    DT.102821683  DT.121110008  DT.100692824  DT.40224908 

    22 AceView cDNA sequences:

    BX090841 AA283601 NM_006611 AF047445 BX118035 BC069697 AA464841 BQ772043 
    BU678177 BC069672 AY334570 CF995060 BX950927 BC069734 BE220332 BE350011 
    AI659462 CB990552 BI757398 BF195284 BF907137 BF887258 

    GeneLoc Exon Structure


    Expression
    for KLRAP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLRAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAAATGACA
    KLRAP1 Expression
    About this image
    Genevestigator expression for KLRAP1

    SOURCE GeneReport for Unigene cluster: Hs.159297
        SABiosciences Custom PCR Arrays for KLRAP1

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    In Situ
    Assay Products:     
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    Orthologs
    for KLRAP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLRAP1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Klra25 killer cell lectin-like receptor, subfamily A, member more   --   6 (63.44 cM) 131219223 


    ENSEMBL Gene Tree for KLRAP1 (if available)
    TreeFam Gene Tree for KLRAP1 (if available) 

    Paralogs
    for KLRAP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for KLRAP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/330 NCBI SNPs in KLRAP1 are shown (see all 330)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs788697941,2
    		F--10740815(+) AAACCA/GTAGAT 1 -- ds50011Minor allele frequency- G:0.17WA 118
    rs1140354271,2
    		--10740840(+) TGCTGC/TGTAAA 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1145983741,2
    		F--10740870(+) AGTACA/GTGATG 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs73087301,2
    		C,F,A,H--10740921(+) aagcaC/Tatccc 1 -- ds50018Minor allele frequency- T:0.24NS NA WA CSA 364
    rs1143124141,2
    		F--10740935(+) TTGCCT/CGGGGC 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs26824741,2
    		C,F,A,H--10741013(+) tactgT/Ggtaag 1 -- ds500112Minor allele frequency- G:0.30NS EA NA WA 776
    rs619131191,2
    		C--10741027(+) TATATA/GTGTGG 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs72973831,2
    		C,F--10741032(+) GTGTGT/GGTGTG 1 -- ds50016Minor allele frequency- G:0.18WA NA CSA 11
    rs1476146851,2
    		--10741119(+) TCAAT-/AAAGTTA 1 -- nc-transcript-variant0--------
    rs780744061,2
    		F--10741161(+) CTAAAG/AAACTG 1 -- nc-transcript-variant1Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for KLRAP1 (10741077 - 10752434 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLRAP1: --

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    Disorders / Diseases
    for KLRAP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLRAP1 for disorders           About GeneDecksing

    OMIM gene information: 604274    OMIM disorders: --

    4 diseases for KLRAP1:    About MalaCards
    graft versus host disease    cytomegalovirus infection    hepatitis b    hepatitis


    Export disorders for KLRAP1 gene to outside databases

    Publications
    for KLRAP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLRAP1 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with KLRAP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human member of the Ly-49 multigene family. (PubMed id 9645365)1, 3, 9 Westgaard I.H.... Dissen E. (1998)
    2. Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors. (PubMed id 18426793)1, 9 Deng L....Mariuzza R.A. (2008)
    3. Comparative genomics of natural killer cell receptor gene clusters. (PubMed id 16132082)1, 9 Kelley J....Trowsdale J. (2005)
    4. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. (PubMed id 9830044)1, 9 McVicar D.W....Mason L.H. (1998)
    5. Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint. (PubMed id 21632721)1 Merck E....MacDonald H.R. (2011)
    6. Ly49-dependent NK cell licensing and effector inhibit ion involve the same interaction site on MHC ligands. (PubMed id 21335486)1 Choi T....Yokoyama W.M. (2011)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. (PubMed id 19929986)1 Craig D.W....DiStefano J.K. (2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for KLRAP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KLRAP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10748 HGNC: 6372 AceView: KLRA1 Ensembl:ENSG00000256667 euGenes: HUgn10748
    ECgene: KLRAP1 H-InvDB: KLRAP1

    Other Databases showing KLRAP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLRAP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLRAP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KLRAP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLRAP1 gene:
    Search GeneIP for patents involving KLRAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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