KLLN Gene
protein-coding GIFtS: 32
GCID: GC10M089619
|
|
killin, p53-regulated DNA replication inhibitor
| |
Aliases
for KLLN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Killin, P53-Regulated DNA Replication Inhibitor1 2 | | Killin1 | | KILLIN2 | | KLN5 |
Export aliases for KLLN gene to outside databases |
Summaries
for KLLN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLLN:
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote Sphase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factorp53. (provided by RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: KILIN_HUMAN, B2CW77Function: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-inducedapoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to bothdouble- and single-stranded DNA
|
Genomic Views
for KLLN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KLLN
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLLN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLLN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23KLLN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M089619: view genomic region
(about GC identifiers)
Start:
|
89,618,918 bp from pter |
End:
|
89,623,194 bp from pter |
Size:
|
4,277 bases |
Orientation:
|
minus strand |
|
Proteins
for KLLN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KILIN_HUMAN, B2CW77 (See
protein sequence)Recommended Name: Killin Size: 178 amino acids; 19958 Da
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for KLLN: NX_B2CW77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_B2CW77
KLLN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001119521.1
ENSEMBL proteins: ENSP00000392204
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
KLLN for ontologies About GeneDecksing
KLLN Antibody Products:
Assay Products for KLLN: |
Protein
Domains /
Families
for KLLN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: B2CW77 |
Function
for KLLN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KILIN_HUMAN, B2CW77Function: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-inducedapoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to bothdouble- and single-stranded DNAInduction: By p53/TP53; direct transcription target of p53/TP53
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLLN
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLLN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLLN (NM_001126049) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLLN | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KLLN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLLN |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
KLLN for ontologies About GeneDecksing
|
Pathways & Interactions
for KLLN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLLN
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
KLLN for ontologies About GeneDecksing
|
Drugs & Compounds
for KLLN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLLN
Search CenterWatch for drugs/clinical trials and news about KLLN / KILIN
|
Transcripts
for KLLN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLLN gene: NM_001126049.1 Unigene Cluster for KLLN: Killin, p53-regulated DNA replication inhibitor Hs.559820 [show with all ESTs]Unigene Representative Sequence: EU5520921 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000445946(uc009xti.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLLN
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLLN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLLN (NM_001126049) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLLN | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KLLN |
Additional cDNA sequence: EU552092.1 2 DOTS entries: DT.107155 DT.75116470
GeneLoc Exon Structure
|
Expression
for KLLN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLLN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KLLN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLLN
SOURCE GeneReport for Unigene cluster: Hs.559820
SABiosciences Custom PCR Arrays for KLLN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLLN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KLLN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLLN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLLN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLLN |
Orthologs
for KLLN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for KLLN (if available)
TreeFam Gene Tree for KLLN (if available) |
Paralogs
for KLLN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KLLN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLLN (89618918 - 89623194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLLN: --
Human Gene Mutation Database (HGMD): KLLN
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLLN |
|
Disorders
/ Diseases
for KLLN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLLN for disorders About GeneDecksing
OMIM gene information: 612105
OMIM disorders: --
4  diseases for KLLN: About MalaCardscowden-like syndrome renal cell carcinoma thyroiditis carcinoma
Export disorders for KLLN gene to outside databases
|
Publications
for KLLN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLLN gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLLN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Killin is a p53-regulated nuclear inhibitor of DNA synthesis. (PubMed id 18385383)1, 2, 3 Cho Y.J. and Liang P. (2008)
- Analysis of KLLN as a high-penetrance breast cancer predisposition gene. (PubMed id 22580995)1 Thompson E.R....Campbell I.G. (2012)
- Germline and somatic DNA methylation and epigenetic r egulation of KILLIN in renal cell carcinoma. (PubMed id 21584899)1 Bennett K.L....Eng C. (2011)
- Incidence and clinical characteristics of thyroid can cer in prospective series of individuals with Cowden and Cowden-like syndrome c haracterized by germline PTEN, SDH, or KLLN alterations. (PubMed id 21956414)1 Ngeow J....Eng C. (2011)
- Germline epigenetic regulation of KILLIN in Cowden an d Cowden-like syndrome. (PubMed id 21177507)1 Bennett K.L....Eng C. (2010)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for KLLN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLLN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLLN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLLN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KLLN gene:
Search GeneIP for patents involving KLLN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLLN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLLN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLLN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLLN | | | OriGene Protein Over-expression Lysate for KLLN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLLN | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLLN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLLN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLLN | | OriGene Custom Protein Services for KLLN | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLLN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLLN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLLN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLLN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLLN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLLN |
| |
 |  |  |  | |
| | | | Search Tocris compounds for KLLN |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KLLN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLLN |
|  |  |  | | | | Search ThermoFisher Antibodies for KLLN |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KLLN |
|
|
|
|
