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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLKP1 Gene

pseudogene   GIFtS: 24
GCID: GC19M051385

Kallikrein Pseudogene 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
Kallikrein Pseudogene 11 2     PsiKLK12
KARMA2 3     YKLK12
KLK31P2 3     Kallikrein-Related In Prostate Protein 13
Kallikrein 31 Pseudogene1     Kallikrein-Related MRNA Protein3
KRSP12     

External Ids:    HGNC: 212601   Entrez Gene: 6062932   Ensembl: ENSG000001975887   UniProtKB: Q107X03   
ORGUL members:         
NONCODE14:n376191 n376218      

Export aliases for KLKP1 gene to outside databases

Previous GC identifers: GC19U900554 GC19M056077 GC19M047720


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLKP1 Gene: 
KLKP1 (kallikrein pseudogene 1) is a pseudogene, and is affiliated with the lncRNA class. Diseases associated with KLKP1 include prostate cancer, progression of, and prostatitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLKP1 gene promoter:
         GR   NF-1   JunB   GR-beta   p300   GATA-1   MEF-2A   JunD   GR-alpha   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KLKP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLKP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.41

KLKP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLKP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051385:  view genomic region     (about GC identifiers)

Start:
51,385,352 bp from pter      End:
51,399,654 bp from pter
Size:
14,303 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for KLKP1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KRIP1_HUMAN, Q107X0 (See protein sequence)
Recommended Name: Putative protein KRIP1  
Size: 134 amino acids; 14401 Da
Subcellular location: Cytoplasm. Nucleus
Caution: Was named (PubMed:18196551) 'Kallikrein-related in prostate protein 1' because this protein is encoded by
a transcript from the KLKP1 gene region. It is encoded in an exon which is similar to the intronic region between
exons 1 and 2 of KLK1, KLK2 and KLK3
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for KLKP1: NX_Q107X0

KLKP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm IEA--

KLKP1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KLK: Kallikreins

ProtoNet protein and cluster: Q107X0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KRIP1_HUMAN, Q107X0
Induction: By androgens

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLKP1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for KLKP1 (KRIP1)

Search CenterWatch for drugs/clinical trials and news about KLKP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for KLKP1:

Kallikrein pseudogene 1
Hs.643424  [show with all ESTs]
Unigene Representative Sequence: DQ211698
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000600104 ENST00000597246 ENST00000595979 ENST00000358534
miRNA
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Additional mRNA sequence: 

AF355199.1 AF464754.1 AY533562.1 DQ086829.1 DQ211698.1 NR_002948.1 

2 DOTS entries:

DT.99954727  DT.121421907 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLKP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KLKP1 Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.643424

UniProtKB/Swiss-Prot: KRIP1_HUMAN, Q107X0
Tissue specificity: Abundant expression is found in prostate, restricted to cells of epithelial origin in normal
and diseased glands. Very low expression is detected in pancreas and ovary

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLKP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for KLKP1 (if available)
TreeFam Gene Tree for KLKP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/418 SNPs in KLKP1 are shown (see all 418)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1484907211,2
--51384899(+) AGGGAC/GTATAA 1 -- int10--------
rs1147349991,2
F--51384902(+) GAGTAT/CAAATT 1 -- int11Minor allele frequency- C:0.03WA 118
rs1152542351,2
F--51384929(+) AAAATG/AATTTA 1 -- int11Minor allele frequency- A:0.01WA 118
rs1426810631,2
--51384935(+) ATTTAA/GAAGTA 1 -- int10--------
rs1813723191,2
--51384941(+) AAGTAC/TATGTT 1 -- int10--------
rs1852557791,2
--51384957(+) TGAACA/GTATGC 1 -- int10--------
rs793748011,2
F--51384982(+) TCAATC/TTTAGA 1 -- int11Minor allele frequency- T:0.01WA 118
rs1900111121,2
--51384990(+) AGAAAC/TATACC 1 -- int10--------
rs1840376321,2
--51384998(+) ACCCCC/TTAGAA 1 -- int10--------
rs1464998701,2
--51385134(+) CAATGA/CATAGT 1 -- int10--------

HapMap Linkage Disequilibrium report for KLKP1 (51385352 - 51399654 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for KLKP1: --
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing KLKP1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for KLKP1:    About MalaCards
prostate cancer, progression of    prostatitis    prostate cancer


KLKP1 for disorders           About GeneDecksing


Export disorders for KLKP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KLKP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLKP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel transcript from the KLKP1 gene is androgen regulated, down-regulated during prostate cancer progression and encodes the first non-serine protease identified from the human kallikrein gene locus. (PubMed id 18196551)1, 2, 3, 9 Kaushal A....Hooper J.D. (2008)
  2. KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cells. (PubMed id 16541416)1, 2, 3 Lu W....Lin B. (2006)
  3. Cloning of a kallikrein pseudogene. (PubMed id 15498522)1, 3 Yousef G.M....Diamandis E.P. (2004)
  4. Genome-wide association study identifies loci at ATF7I P and KLK2 associated with percentage of circulating free PSA. (PubMed id 23359319)1 Jin G....Xu J. (2013)
  5. Kallikreins on steroids: structure, function, and hor monal regulation of prostate-specific antigen and the extended kallikrein locus . (PubMed id 20103546)1 Lawrence M.G....Clements J.A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 606293 HGNC: 21260 Ensembl:ENSG00000197588 euGenes: HUgn606293 ECgene: KLKP1
H-InvDB: KLKP1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KLKP1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KLKP1 gene:
Search GeneIP for patents involving KLKP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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