Aliases for KLKB1 Gene
External Ids for KLKB1 Gene
Previous Symbols for KLKB1 Gene
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLKB1 Gene
KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1) is a Protein Coding gene. Diseases associated with KLKB1 include fletcher factor deficiency and prekallikrein deficiency, congenital. Among its related pathways are Pathways in cancer and Hemostasis. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HPN.
UniProtKB/Swiss-Prot for KLKB1 Gene
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin