KLK9 Gene
protein-coding GIFtS: 50
GCID: GC19M051505
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kallikrein-related peptidase 9(Previous name: kallikrein 9 )
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Aliases
for KLK9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kallikrein-Related Peptidase 91 2 | | Kallikrein-91 | | KLK-L31 2 3 | | EC 3.4.21.-3 | | Kallikrein-Like Protein 32 3 | | EC 3.4.218 | | KLKL32 5 | | EC 3.4.21.48 | | Kallikrein 91 | | |
Export aliases for KLK9 gene to outside databasesPrevious GC identifers: GC19M052136 GC19M051867 GC19M056181 GC19M056192 GC19M056197 GC19M056194 GC19M047838 |
Summaries
for KLK9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLK9:
The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones ina human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarilyin the cytoplasm.(provided by RefSeq, Oct 2010)
Gene Wiki entry for KLK9
|
Genomic Views
for KLK9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLK9 gene promoter:
HEN1 ER-alpha AML1a c-Myb ZID NF-E2 NF-E2 p45 Zic3 Gfi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLK9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.33KLK9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M051505: view genomic region
(about GC identifiers)
Start:
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51,503,806 bp from pter |
End:
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51,512,890 bp from pter |
Size:
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9,085 bases |
Orientation:
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minus strand |
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Proteins
for KLK9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLK9_HUMAN, Q9UKQ9 (See
protein sequence)Recommended Name: Kallikrein-9 precursor Size: 250 amino acids; 27513 Da
Subcellular location: Secreted (Probable)Explore the universe of human proteins at neXtProt for KLK9: NX_Q9UKQ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKQ9
4/5 DME Specific Peptides for KLK9 (Q9UKQ9) (see all 5)
KLK9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036447.1
ENSEMBL proteins: ENSP00000366028 ENSP00000250366 ENSP00000443289
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- |
KLK9 for ontologies About GeneDecksing
KLK9 Antibody Products:
Assay Products for KLK9: |
Protein
Domains /
Families
for KLK9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLK9 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKQ9ProtoNet protein and cluster: Q9UKQ9 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: KLK9_HUMAN, Q9UKQ9Similarity: Belongs to the peptidase S1 family. Kallikrein subfamilySimilarity: Contains 1 peptidase S1 domain |
Function
for KLK9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: KLK9 (NM_012315) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLK9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
NAS | 11054574 |
KLK9 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KLK9:
|
Pathways & Interactions
for KLK9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Blood Coagulation Cascade | | | 2 | MSP-RON Signaling | |
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK9
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLK9
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
NAS | -- |
KLK9 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLK9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLK9
Search CenterWatch for drugs/clinical trials and news about KLK9
|
Transcripts
for KLK9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLK9 gene: NM_012315.1 Unigene Cluster for KLK9: Kallikrein-related peptidase 9 Hs.448942 [show with all ESTs]Unigene Representative Sequence: NM_0123153 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376832(uc002puv.1 uc002puw.1 uc002pux.1 uc010eol.1)
ENST00000250366 ENST00000544410
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLK9 (NM_012315) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLK9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK9 |
2 DOTS entries: DT.121457224 DT.102821852 24/47 AceView cDNA sequences (see all 47): BM762825 BC040887 CR601157 AB009849 BF915088 NM_007196 BX282429 AY359036 NM_144505 BI041913 NM_144506 AF095742 NM_012315 AY551001 NM_144507 AL551079 AB008390 AY566267 AA343629 AI566249 AI963941 AI916929 AB008927 BM845575
GeneLoc Exon Structure
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Expression
for KLK9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLK9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAACTGAG
About this image
See KLK9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLK9
SOURCE GeneReport for Unigene cluster: Hs.448942
UniProtKB/Swiss-Prot: KLK9_HUMAN, Q9UKQ9Tissue specificity: Skin, thymus, trachea, cerebellum and spinal cord
SABiosciences Custom PCR Arrays for KLK9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK9 |
Orthologs
for KLK9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for KLK9 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for KLK9 (if available)
TreeFam Gene Tree for KLK9 (if available) |
Paralogs
for KLK9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLK9 gene
- KLK102 KLK12 KLK42 PRSS372 KLK112 KLK72 KLK142 KLK132
- KLK62 KLK122 KLK22 KLK152 KLK52 PRSS12 PRSS582 PRSS32
- KLK32 KLK82
18/114 SIMAP similar genes for KLK9 using alignment to 5 protein entries: KLK9_HUMAN (see all proteins)
(see all similar genes):KLK8 KLK11 KLK14 KLK5 KLK13 TRY6
KLK12 PRSS47 KLK15 APS KLK6 KLK7
KLK10 PRSS1 TRY8 PRSS3 MGC52282 KLK2
KLK9 for paralogs About GeneDecksing
|
Genomic Variants
for KLK9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLK9 (51503806 - 51512890 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLK9
1 CNV: 67588 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK9 |
|
Disorders
/ Diseases
for KLK9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLK9 for disorders About GeneDecksing
OMIM gene information: 605504
OMIM disorders: --
4  diseases for KLK9: About MalaCardsbreast cancer ovarian cancer prostate cancer prostatitis
Human Genome Epidemiology (HuGE) Navigator: KLK9 (1 document)
Export disorders for KLK9 gene to outside databases
|
Publications
for KLK9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLK9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLK9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3. (PubMed id 10783266)1, 2, 9 Yousef G.M. and Diamandis E.P. (2000)
- A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)
- Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2 Gan L.... Wang K. (2000)
- Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PubMed id 10652563)1, 2 Yousef G.M.... Diamandis E.P. (1999)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1 Klein R.J....Lilja H. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker. (PubMed id 11691797)1 Yousef G.M....Katsaros D. (2001)
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External Searches for KLK9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KLK9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLK9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLK9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLK9 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KLK9 gene:
Search GeneIP for patents involving KLK9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLK9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for KLK9 | | OriGene shRNA RFP for KLK9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK9 | | | OriGene Protein Over-expression Lysate for KLK9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLK9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KLK9 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLK9 | | OriGene Custom Protein Services for KLK9 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLK9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK9 |
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| | | | Search Tocris compounds for KLK9 |
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 | | | KLK9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK9 |
|  |  |  | | | | ThermoFisher Antibodies for KLK9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK9 |
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