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Aliases for KLK9 Gene

Aliases for KLK9 Gene

  • Kallikrein-Related Peptidase 9 2 3
  • Kallikrein-Like Protein 3 3 4
  • KLK-L3 3 4
  • KLKL3 3 6
  • Kallikrein 9 2
  • Kallikrein-9 3
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for KLK9 Gene

Previous GeneCards Identifiers for KLK9 Gene

  • GC19M052136
  • GC19M051867
  • GC19M056181
  • GC19M056192
  • GC19M056197
  • GC19M056194
  • GC19M051505
  • GC19M047838

Summaries for KLK9 Gene

Entrez Gene Summary for KLK9 Gene

  • The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]

GeneCards Summary for KLK9 Gene

KLK9 (Kallikrein-Related Peptidase 9) is a Protein Coding gene. Diseases associated with KLK9 include breast cancer. Among its related pathways are Collagen biosynthesis and modifying enzymes and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

Gene Wiki entry for KLK9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK9 Gene

Genomics for KLK9 Gene

Regulatory Elements for KLK9 Gene

Genomic Location for KLK9 Gene

51,002,513 bp from pter
51,009,634 bp from pter
7,122 bases
Minus strand

Genomic View for KLK9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK9 Gene

Proteins for KLK9 Gene

  • Protein details for KLK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6QA55

    Protein attributes for KLK9 Gene

    250 amino acids
    Molecular mass:
    27513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK9 Gene


neXtProt entry for KLK9 Gene

Proteomics data for KLK9 Gene at MOPED

Selected DME Specific Peptides for KLK9 Gene

Post-translational modifications for KLK9 Gene

  • Glycosylation at Asn131, Asn166, and Asn211
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KLK9

Domains for KLK9 Gene

Gene Families for KLK9 Gene

  • KLK :Kallikreins

Graphical View of Domain Structure for InterPro Entry



  • Q9UKQ9
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK9: view

Function for KLK9 Gene

Enzyme Numbers (IUBMB) for KLK9 Gene

Gene Ontology (GO) - Molecular Function for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 11054574
genes like me logo Genes that share ontologies with KLK9: view

Phenotypes for KLK9 Gene

MGI mutant phenotypes for KLK9:
inferred from 1 alleles
GenomeRNAi human phenotypes for KLK9:
genes like me logo Genes that share phenotypes with KLK9: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLK9 Gene

Localization for KLK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK9 Gene


Subcellular locations from

Jensen Localization Image for KLK9 Gene COMPARTMENTS Subcellular localization image for KLK9 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK9: view

Pathways for KLK9 Gene

genes like me logo Genes that share pathways with KLK9: view

Pathways by source for KLK9 Gene

Interacting Proteins for KLK9 Gene

Gene Ontology (GO) - Biological Process for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK9: view

Transcripts for KLK9 Gene

mRNA/cDNA for KLK9 Gene

(0) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLK9 Gene

Kallikrein-related peptidase 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK9 Gene

No ASD Table

Relevant External Links for KLK9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK9 Gene

mRNA expression in normal human tissues for KLK9 Gene

SOURCE GeneReport for Unigene cluster for KLK9 Gene Hs.448942

mRNA Expression by UniProt/SwissProt for KLK9 Gene

Tissue specificity: Skin, thymus, trachea, cerebellum and spinal cord
genes like me logo Genes that share expressions with KLK9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for KLK9 Gene

Orthologs for KLK9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLK9 35
  • 87.07 (n)
  • 88.4 (a)
KLK9 36
  • 88 (a)
(Canis familiaris)
Mammalia KLK9 35
  • 88.4 (n)
  • 89.2 (a)
-- 36
  • 23 (a)
(Mus musculus)
Mammalia Klk9 35
  • 78.3 (n)
  • 80 (a)
Klk9 16
Klk9 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Klk9 35
  • 79.15 (n)
  • 82.13 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
Species with no ortholog for KLK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK9 Gene

Gene Tree for KLK9 (if available)
Gene Tree for KLK9 (if available)

Paralogs for KLK9 Gene

genes like me logo Genes that share paralogs with KLK9: view

Variants for KLK9 Gene

Sequence variations from dbSNP and Humsavar for KLK9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs885756 -- 51,010,159(-) CTTTC(C/T)CGTGT upstream-variant-2KB
rs952108 -- 51,008,674(-) ATGAA(C/T)GATAC intron-variant
rs952109 -- 51,008,614(-) ACACA(C/T)ATAGC intron-variant
rs1007755 -- 51,007,512(+) AAGTA(A/G)TCCTC intron-variant
rs1722551 -- 51,004,699(+) tcagt(C/T)tctta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK9 Gene

Variant ID Type Subtype PubMed ID
nsv912291 CNV Loss 21882294
esv2671814 CNV Deletion 23128226
esv29146 CNV Loss 19812545

Relevant External Links for KLK9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK9 Gene

Disorders for KLK9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KLK9 Gene in MalaCards »

(1) Diseases for KLK9 Gene including...

Relevant External Links for KLK9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLK9: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLK9 Gene

Publications for KLK9 Gene

  1. The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3. (PMID: 10783266) Yousef G.M. … Diamandis E.P. (Genomics 2000) 3 4 23
  2. Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PMID: 10652563) Yousef G.M. … Diamandis E.P. (Anticancer Res. 1999) 3 4
  3. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PMID: 11054574) Gan L. … Wang K. (Gene 2000) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 3

Products for KLK9 Gene

Sources for KLK9 Gene

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