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Aliases for KLK9 Gene

Aliases for KLK9 Gene

  • Kallikrein Related Peptidase 9 2 3 5
  • Kallikrein-Like Protein 3 3 4
  • KLK-L3 3 4
  • Kallikrein 9 2
  • Kallikrein-9 3
  • EC 3.4.21.4 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • KLKL3 3

External Ids for KLK9 Gene

Previous GeneCards Identifiers for KLK9 Gene

  • GC19M052136
  • GC19M051867
  • GC19M056181
  • GC19M056192
  • GC19M056197
  • GC19M056194
  • GC19M051505
  • GC19M047838

Summaries for KLK9 Gene

Entrez Gene Summary for KLK9 Gene

  • The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]

GeneCards Summary for KLK9 Gene

KLK9 (Kallikrein Related Peptidase 9) is a Protein Coding gene. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ENSG00000269741.

Gene Wiki entry for KLK9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK9 Gene

Genomics for KLK9 Gene

Regulatory Elements for KLK9 Gene

Enhancers for KLK9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051009 1.3 Ensembl ENCODE 0.8 -0.5 -531 1.9 TFDP1 PKNOX1 ZFP3 PBX2 FOS KLK9 ENSG00000268739
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KLK9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK9 Gene

Chromosome:
19
Start:
51,002,513 bp from pter
End:
51,009,634 bp from pter
Size:
7,122 bases
Orientation:
Minus strand

Genomic View for KLK9 Gene

Genes around KLK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK9 Gene

Proteins for KLK9 Gene

  • Protein details for KLK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKQ9-KLK9_HUMAN
    Recommended name:
    Kallikrein-9
    Protein Accession:
    Q9UKQ9
    Secondary Accessions:
    • Q6QA55

    Protein attributes for KLK9 Gene

    Size:
    250 amino acids
    Molecular mass:
    27513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK9 Gene

Selected DME Specific Peptides for KLK9 Gene

Q9UKQ9:
  • GDSGGPL
  • CLISGWG
  • SGGPLVC
  • CQGDSGGP
  • DIMLIRL

Post-translational modifications for KLK9 Gene

  • Glycosylation at Asn 131, Asn 166, and Asn 211
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KLK9 Gene

Gene Families for KLK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKQ9

UniProtKB/Swiss-Prot:

KLK9_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK9: view

Function for KLK9 Gene

Enzyme Numbers (IUBMB) for KLK9 Gene

Gene Ontology (GO) - Molecular Function for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11054574
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK9: view
genes like me logo Genes that share phenotypes with KLK9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK9

miRNA for KLK9 Gene

miRTarBase miRNAs that target KLK9

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK9 Gene

Localization for KLK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK9 Gene COMPARTMENTS Subcellular localization image for KLK9 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK9: view

Pathways & Interactions for KLK9 Gene

genes like me logo Genes that share pathways with KLK9: view

Pathways by source for KLK9 Gene

Interacting Proteins for KLK9 Gene

Gene Ontology (GO) - Biological Process for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK9: view

No data available for SIGNOR curated interactions for KLK9 Gene

Transcripts for KLK9 Gene

mRNA/cDNA for KLK9 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(47) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLK9 Gene

Kallikrein-related peptidase 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK9 Gene

No ASD Table

Relevant External Links for KLK9 Gene

GeneLoc Exon Structure for
KLK9
ECgene alternative splicing isoforms for
KLK9

Expression for KLK9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLK9 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLK9 Gene:

KLK9

SOURCE GeneReport for Unigene cluster for KLK9 Gene:

Hs.448942

mRNA Expression by UniProt/SwissProt for KLK9 Gene:

Q9UKQ9-KLK9_HUMAN
Tissue specificity: Skin, thymus, trachea, cerebellum and spinal cord.
genes like me logo Genes that share expression patterns with KLK9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KLK9 Gene

Orthologs for KLK9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia KLK9 34
  • 88.4 (n)
-- 35
  • 23 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia KLK9 34 35
  • 87.07 (n)
rat
(Rattus norvegicus)
Mammalia Klk9 34
  • 79.15 (n)
mouse
(Mus musculus)
Mammalia Klk9 34 16 35
  • 78.3 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
OneToMany
Species where no ortholog for KLK9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK9 Gene

ENSEMBL:
Gene Tree for KLK9 (if available)
TreeFam:
Gene Tree for KLK9 (if available)

Paralogs for KLK9 Gene

genes like me logo Genes that share paralogs with KLK9: view

Variants for KLK9 Gene

Sequence variations from dbSNP and Humsavar for KLK9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1007755 -- 51,007,512(+) AAGTA(A/G)TCCTC intron-variant
rs10401205 -- 51,005,630(+) GATTC(C/T)GACAC intron-variant
rs10404395 -- 51,002,840(+) GTGCT(C/G)TTCCA upstream-variant-2KB, utr-variant-3-prime
rs10420303 -- 51,004,785(+) AGATT(C/T)GCAGG intron-variant
rs10426081 -- 51,005,640(+) CACTA(G/T)TATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK9 Gene

Variant ID Type Subtype PubMed ID
dgv6515n54 CNV loss 21841781
dgv6516n54 CNV loss 21841781
esv2671814 CNV deletion 23128226
esv29146 CNV loss 19812545
esv3644663 CNV loss 21293372
nsv1058277 CNV gain 25217958
nsv1112751 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv579961 CNV loss 21841781

Variation tolerance for KLK9 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK9 Gene

Disorders for KLK9 Gene

Relevant External Links for KLK9

Genetic Association Database (GAD)
KLK9
Human Genome Epidemiology (HuGE) Navigator
KLK9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK9

No disorders were found for KLK9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK9 Gene

Publications for KLK9 Gene

  1. The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3. (PMID: 10783266) Yousef G.M. … Diamandis E.P. (Genomics 2000) 3 4 22 64
  2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein R.J. … Lilja H. (Cancer Prev Res (Phila) 2010) 3 46 64
  3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 3 64
  4. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A. … Yousef G.M. (Biol. Chem. 2006) 2 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for KLK9 Gene

Sources for KLK9 Gene

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