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Aliases for KLK9 Gene

Aliases for KLK9 Gene

  • Kallikrein Related Peptidase 9 2 3 5
  • Kallikrein-Like Protein 3 3 4
  • KLK-L3 3 4
  • Kallikrein-Related Peptidase 9 3
  • Kallikrein 9 2
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • KLKL3 3

External Ids for KLK9 Gene

Previous GeneCards Identifiers for KLK9 Gene

  • GC19M052136
  • GC19M051867
  • GC19M056181
  • GC19M056192
  • GC19M056197
  • GC19M056194
  • GC19M051505
  • GC19M047838

Summaries for KLK9 Gene

Entrez Gene Summary for KLK9 Gene

  • The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]

GeneCards Summary for KLK9 Gene

KLK9 (Kallikrein Related Peptidase 9) is a Protein Coding gene. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

Gene Wiki entry for KLK9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK9 Gene

Genomics for KLK9 Gene

Regulatory Elements for KLK9 Gene

Enhancers for KLK9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLK9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK9 Gene

Chromosome:
19
Start:
51,002,513 bp from pter
End:
51,009,634 bp from pter
Size:
7,122 bases
Orientation:
Minus strand

Genomic View for KLK9 Gene

Genes around KLK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK9 Gene

Proteins for KLK9 Gene

  • Protein details for KLK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKQ9-KLK9_HUMAN
    Recommended name:
    Kallikrein-9
    Protein Accession:
    Q9UKQ9
    Secondary Accessions:
    • Q6QA55

    Protein attributes for KLK9 Gene

    Size:
    250 amino acids
    Molecular mass:
    27513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK9 Gene

Proteomics data for KLK9 Gene at MOPED

Selected DME Specific Peptides for KLK9 Gene

Post-translational modifications for KLK9 Gene

  • Glycosylation at Asn 131, Asn 166, and Asn 211
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KLK9

Domains & Families for KLK9 Gene

Gene Families for KLK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKQ9

UniProtKB/Swiss-Prot:

KLK9_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK9: view

Function for KLK9 Gene

Enzyme Numbers (IUBMB) for KLK9 Gene

genes like me logo Genes that share phenotypes with KLK9: view

Animal Models for KLK9 Gene

MGI Knock Outs for KLK9:
  • Klk9 tm1a(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK9

miRNA for KLK9 Gene

miRTarBase miRNAs that target KLK9

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLK9 Gene

Localization for KLK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK9 Gene COMPARTMENTS Subcellular localization image for KLK9 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for KLK9 Gene

Pathways & Interactions for KLK9 Gene

genes like me logo Genes that share pathways with KLK9: view

Pathways by source for KLK9 Gene

Interacting Proteins for KLK9 Gene

Gene Ontology (GO) - Biological Process for KLK9 Gene

None

No data available for SIGNOR curated interactions for KLK9 Gene

Drugs & Compounds for KLK9 Gene

No Compound Related Data Available

Transcripts for KLK9 Gene

mRNA/cDNA for KLK9 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLK9 Gene

Kallikrein-related peptidase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK9 Gene

No ASD Table

Relevant External Links for KLK9 Gene

GeneLoc Exon Structure for
KLK9
ECgene alternative splicing isoforms for
KLK9

Expression for KLK9 Gene

mRNA expression in normal human tissues for KLK9 Gene

SOURCE GeneReport for Unigene cluster for KLK9 Gene Hs.448942

mRNA Expression by UniProt/SwissProt for KLK9 Gene

Q9UKQ9-KLK9_HUMAN
Tissue specificity: Skin, thymus, trachea, cerebellum and spinal cord.
genes like me logo Genes that share expression patterns with KLK9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KLK9 Gene

Orthologs for KLK9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK9 35
  • 87.07 (n)
  • 88.4 (a)
KLK9 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KLK9 35
  • 88.4 (n)
  • 89.2 (a)
-- 36
  • 23 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Klk9 35
  • 78.3 (n)
  • 80 (a)
Klk9 16
Klk9 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Klk9 35
  • 79.15 (n)
  • 82.13 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
Species with no ortholog for KLK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK9 Gene

ENSEMBL:
Gene Tree for KLK9 (if available)
TreeFam:
Gene Tree for KLK9 (if available)

Paralogs for KLK9 Gene

genes like me logo Genes that share paralogs with KLK9: view

Variants for KLK9 Gene

Sequence variations from dbSNP and Humsavar for KLK9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7507626 -- 51,007,426(+) TGACT(A/G)CGAAT intron-variant
rs885756 -- 51,010,159(-) CTTTC(C/T)CGTGT upstream-variant-2KB
rs952108 -- 51,008,674(-) ATGAA(C/T)GATAC intron-variant
rs952109 -- 51,008,614(-) ACACA(A/C/T)ATAGC intron-variant
rs1007755 -- 51,007,512(+) AAGTA(A/G)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK9 Gene

Variant ID Type Subtype PubMed ID
nsv912291 CNV Loss 21882294
esv2671814 CNV Deletion 23128226
esv29146 CNV Loss 19812545

Variation tolerance for KLK9 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLK9 Gene

Disorders for KLK9 Gene

Relevant External Links for KLK9

Genetic Association Database (GAD)
KLK9
Human Genome Epidemiology (HuGE) Navigator
KLK9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK9

No disorders were found for KLK9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK9 Gene

Publications for KLK9 Gene

  1. The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3. (PMID: 10783266) Yousef G.M. … Diamandis E.P. (Genomics 2000) 3 4 23 67
  2. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 3
  3. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A. … Yousef G.M. (Biol. Chem. 2006) 2 3
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  5. Human tissue kallikrein 9 in asthmatic patients. (PMID: 25747782) Nasim F.U. … Ahmad S. (Ann. Allergy Asthma Immunol. 2015) 3

Products for KLK9 Gene

Sources for KLK9 Gene

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