KLK8 Gene
protein-coding GIFtS: 56
GCID: GC19M051499
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|
kallikrein-related peptidase 8(Previous name: kallikrein 8 (neuropsin/ovasin) )
(Previous symbol: PRSS19)
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Aliases
for KLK8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kallikrein-Related Peptidase 81 2 | | Kallikrein 8 (Neuropsin/Ovasin)1 | | PRSS191 2 3 5 | | Neuropsin3 | | TADG141 2 3 5 | | Kallikrein-81 | | HNP1 2 | | KLK8 Protein Type 12 | | Ovasin3 | | KLK8 Protein Type 22 | | Serine Protease 192 3 | | Neuropsin Type 12 | | Serine Protease TADG-142 3 | | Neuropsin Type 22 | | Tumor-Associated Differentially Expressed Gene 14 Protein2 3 | | EC 3.4.21.1183 | | NP2 3 | | Neuropsin3 | | NRPN2 3 | | Ovasin3 | | HK81 | | EC 3.4.218 |
Export aliases for KLK8 gene to outside databasesPrevious GC identifers: GC19M052129 GC19M051860 GC19M056175 GC19M056191 GC19M047832 |
Summaries
for KLK8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLK8:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests thatmany kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other diseasebiomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoformsexhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KLK8_HUMAN, O60259Function: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen,fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neuriteoutgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphanand small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation inthe hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation andkeratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury
Gene Wiki entry for KLK8
|
Genomic Views
for KLK8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLK8 gene promoter:
Max1 C/EBPbeta AML1a Evi-1 Gfi-1 HEN1 c-Myb Zic3 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLK8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13KLK8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M051499: view genomic region
(about GC identifiers)
Start:
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51,499,264 bp from pter |
End:
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51,504,958 bp from pter |
Size:
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5,695 bases |
Orientation:
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minus strand |
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Proteins
for KLK8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLK8_HUMAN, O60259 (See
protein sequence)Recommended Name: Kallikrein-8 precursor Size: 260 amino acids; 28048 Da
Subunit: Interacts with SPINK9
Subcellular location: Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes
Miscellaneous: Expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancerpatients and may serve as a marker of ovarian cancer
Secondary accessions: Q5V9X1 Q5V9X2 Q8IW69 Q9HCB3 Q9NR68 Q9NR69 Q9UIL9 Q9UQ47Alternative splicing: 4 isoforms: O60259-1 O60259-2 O60259-3 O60259-4 (Produced as a result of a human-specific mutation which is not found in other primates)Explore the universe of human proteins at neXtProt for KLK8: NX_O60259
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60259
4/5 DME Specific Peptides for KLK8 (O60259) (see all 5)
KLK8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_009127.1 NP_653088.1 NP_653089.1 NP_653090.1
ENSEMBL proteins: ENSP00000375682 ENSP00000291726 ENSP00000341555 ENSP00000325072
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KLK8 for ontologies About GeneDecksing
KLK8 Antibody Products:
Assay Products for KLK8: |
Protein
Domains /
Families
for KLK8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLK8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60259ProtoNet protein and cluster: O60259 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: KLK8_HUMAN, O60259Similarity: Belongs to the peptidase S1 family. Kallikrein subfamilySimilarity: Contains 1 peptidase S1 domain |
Function
for KLK8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KLK8_HUMAN, O60259Function: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen,fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neuriteoutgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphanand small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation inthe hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation andkeratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injuryCatalytic activity: Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with apreference for Arg over LysEnzyme regulation: Inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin,benzamidine and soybean trypsin inhibitorBiophysicochemical properties: Kinetic parameters: KM=0.07 mM for Pro-Phe-Arg-MCA; KM=0.07 mM for Z-Val-Val-Arg-MCA;KM=0.07 mM for Boc-Val-Pro-Arg-MCA; KM=0.10 mM for Boc-Leu-Lys-Arg-MCA; KM=0.10 mM for Boc-Val-Leu-Lys-MCA; KM=0.07 mMfor Boc-Phe-Ser-Arg-MCA; Vmax=7.1 umol/min/mg enzyme toward Pro-Phe-Arg-MCA; Vmax=5.4 umol/min/mg enzyme towardZ-Val-Val-Arg-MCA; Vmax=3.9 umol/min/mg enzyme toward Boc-Val-Pro-Arg-MCA; Vmax=2.6 umol/min/mg enzyme towardBoc-Leu-Lys-Arg-MCA; Vmax=1.9 umol/min/mg enzyme toward Boc-Val-Leu-Lys-MCA; Vmax=1.6 umol/min/mg enzyme towardBoc-Phe-Ser-Arg-MCA; pH dependence: Optimum pH is 8.5. Active from pH 7-10;Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1181
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK8 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK8 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): KLK8 (NM_007196) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLK8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
KLK8 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KLK8:
Animal Models:
Mouse knock-outs for KLK8: Klk8tm1Shio Klk8tm1Lth
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Klk8):
KLK8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KLK8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Blood Coagulation Cascade | | | 2 | MSP-RON Signaling | |
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK8
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLK8
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for KLK8 (O602593 ENSP000003756824) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
KLK8 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLK8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KLK8 for compounds About GeneDecksing
 Browse Tocris compounds for KLK8
2 Novoseek chemical compound relationships for KLK8 gene About this table
Search CenterWatch for drugs/clinical trials and news about KLK8
|
Transcripts
for KLK8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLK8 gene (4 alternative transcripts): NM_007196.2 NM_144505.1 NM_144506.1 NM_144507.1 Unigene Cluster for KLK8: Kallikrein-related peptidase 8 Hs.104570 [show with all ESTs]Unigene Representative Sequence: NM_1445054 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000391806(uc002puq.1) ENST00000291726(uc002pur.1 uc002puu.1)
ENST00000347619(uc002pus.1) ENST00000320838(uc002put.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK8 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK8 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): KLK8 (NM_007196) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLK8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK8 |
Additional cDNA sequence: AB008390.2 AB008927.1 AB009849.1 AF095742.1 AY359036.1 EU350538.1 EU350539.1 4 DOTS entries: DT.409628 DT.92420073 DT.95340356 DT.102821852 24/47 AceView cDNA sequences (see all 47): AY551001 BC040887 NM_144507 BX282429 NM_144506 BI041913 BF915088 NM_007196 CR601157 NM_144505 BM762825 AB009849 AL551079 AY359036 AA343629 AY566267 AF095742 AB008390 NM_012315 BF032818 BM840716 AA587273 BM845575 AB008927
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLK8 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLK8
|
Expression
for KLK8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLK8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTGTGCAG
About this image
See KLK8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLK8
SOURCE GeneReport for Unigene cluster: Hs.104570
UniProtKB/Swiss-Prot: KLK8_HUMAN, O60259Tissue specificity: Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain andhippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus,thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-foldincrease in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas.Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichenplanus and squamous cell carcinoma skin samples. Expressed in the keratinocytes
SABiosciences Custom PCR Arrays for KLK8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK8 |
Orthologs
for KLK8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLK8 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for KLK8 (if available)
TreeFam Gene Tree for KLK8 (if available) |
Paralogs
for KLK8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLK8 gene
- KLK102 KLK12 KLK42 PRSS372 KLK112 KLK72 KLK142 KLK92
- KLK122 KLK132 KLK62 KLK22 KLK152 KLK52 PRSS12 PRSS582
- PRSS32 KLK32
18/98 SIMAP similar genes for KLK8 using alignment to 6 protein entries: KLK8_HUMAN (see all proteins)
(see all similar genes):KLK9 KLK11 KLK6 KLK13 PRSS1 KLK4
KLK15 KLK7 KLK1 PRSS3 KLK12 KLK2
TRY6 TRY8 KLK14 PRSS2 CMA1 KLK5
KLK8 for paralogs About GeneDecksing
|
Genomic Variants
for KLK8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLK8 (51499264 - 51504958 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLK8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK8 |
|
Disorders
/ Diseases
for KLK8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLK8 for disorders About GeneDecksing
OMIM gene information: 605644
OMIM disorders: --
20/23  diseases for KLK8 (see all 23): About MalaCardsspinal stenosis ovarian cancer spinal cord injury eczema herpeticum
seborrheic keratosis intracranial hypotension lichen planus spondylolisthesis
eczema keratosis radiculopathy squamous cell carcinoma
bipolar disorder ovarian carcinoma psoriasis cervical cancer
alzheimer's disease cervicitis carcinoma lung cancer
2 diseases from the University of Copenhagen DISEASES database for KLK8:Paraganglioma Radiculopathy 7 Novoseek disease relationships for KLK8 gene About this table
Human Genome Epidemiology (HuGE) Navigator: KLK8 (4 documents)
Export disorders for KLK8 gene to outside databases
|
Publications
for KLK8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLK8 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with KLK8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain. (PubMed id 10102990)1, 2, 3, 9 Mitsui S.... Yamaguchi N. (1999)
- Sequence analysis and expression of human neuropsin cDNA and gene. (PubMed id 9714609)1, 2, 3 Yoshida S.... Shiosaka S. (1998)
- The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. (PubMed id 11309326)1, 2, 9 Magklara A.... Diamandis E.P. (2001)
- A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory. (PubMed id 17487847)1, 2, 9 Lu Z.X....Su B. (2007)
- SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PubMed id 19194479)1, 2 Brattsand M.... Egelrud T. (2009)
- SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. (PubMed id 17761692)1, 2 Scott F.L....Bird P.I. (2007)
- Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
- A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)
- Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins. (PubMed id 16337200)1, 2 Rajapakse S.... Takahashi T. (2005)
- Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory. (PubMed id 15282331)1, 2 Li Y....Su B. (2004)
|
External Searches for KLK8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLK8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLK8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLK8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KLK8 gene:
Search GeneIP for patents involving KLK8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLK8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for KLK8 | | OriGene shRNA RFP for KLK8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK8 | | | OriGene Protein Over-expression Lysate for KLK8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLK8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KLK8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLK8 | | OriGene Custom Protein Services for KLK8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLK8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK8 |
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| | | | Search Tocris compounds for KLK8 |
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 | | | KLK8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK8 |
|  |  |  | | | | Search ThermoFisher Antibodies for KLK8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK8 |
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