Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLK7 Gene

protein-coding GIFtS: 60
GCID: GC19M051479

Kallikrein-Related Peptidase 7

(Previous names: kallikrein 7 (chymotryptic, stratum corneum))
(Previous symbol: PRSS6)

Alzheimer's & Parkinson's Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 7¹ ²		hK7² ³
PRSS6¹ ² ³		kallikrein-7²
Kallikrein 7 (Chymotryptic, Stratum Corneum)¹ ²		Signal Protein²
Serine Protease 6² ³		EC 3.4.21.117³
Stratum Corneum Chymotryptic Enzyme² ³		hSCCE³
SCCE² ³		EC 3.4.21⁸

External Ids:	HGNC: 6368¹	Entrez Gene: 5650²	Ensembl: ENSG00000169035⁷	OMIM: 604438⁵	UniProtKB: P49862³

Export aliases for KLK7 gene to outside databases

Previous GC identifers: GC19M052110 GC19M051841 GC19M056155 GC19M056171 GC19M047813

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK7 Gene:

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse

physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has

chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes

desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer

invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and

progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic

dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this

gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. (provided

by RefSeq, May 2011)

GeneCards Summary for KLK7 Gene:

KLK7 (kallikrein-related peptidase 7) is a protein-coding gene. Diseases associated with KLK7 include atopic dermatitis, and netherton syndrome, and among its related super-pathways are Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862

Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in

the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side

chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu- -Cys-7', '16-Tyr- -Leu-17', '25-Phe- -Tyr-26'

and '26-Tyr- -Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines

Gene Wiki entry for KLK7 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.2 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLK7 gene promoter:
MZF-1 MEF-2A HEN1 aMEF-2 Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLK7 promoter sequence

Search SABiosciences Chromatin IP Primers for KLK7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.33

KLK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK7 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M051479: view genomic region (about GC identifiers)

Start:	51,479,729 bp from pter	End:	51,487,355 bp from pter
Size:	7,627 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862 (See protein sequence)

Recommended Name: Kallikrein-7 precursor

Size: 253 amino acids; 27525 Da

Subcellular location: Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and

in cytoplasm at the invasive front

5 PDB 3D structures from and Proteopedia for KLK7:

2QXG (3D)

2QXH (3D)

2QXI (3D)

2QXJ (3D)

3BSQ (3D)

Secondary accessions: Q8N5N9 Q8NFV7

Alternative splicing: 2 isoforms: P49862-1 P49862-2

Explore the universe of human proteins at neXtProt for KLK7: NX_P49862

Explore proteomics data for KLK7 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P49862

4/5 DME Specific Peptides for KLK7 (P49862) (see all 5)

GDSGGPL

VLTAAHC

SGGPLVC

WVLTAAH

KLK7 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (4 alternative transcripts):

NP_001230055.1 NP_001193982.1 NP_005037.1 NP_644806.1

ENSEMBL proteins:

ENSP00000304791 ENSP00000470538 ENSP00000469950 ENSP00000470084 ENSP00000375683

ENSP00000337540

Human Recombinant Protein Products for KLK7:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for KLK7 (Kallikrein 7)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for KLK7 OriGene Protein Over-expression Lysate for KLK7 OriGene MassSpec for KLK7 OriGene Custom Protein Services for KLK7
	GenScript Custom Purified and Recombinant Proteins Services for KLK7
	Novus Biologicals KLK7 Proteins Novus Biologicals KLK7 Lysates
	Sino Biological Recombinant Protein for KLK7 Sino Biological Cell Lysate for KLK7
	ProSpec Recombinant Protein for KLK7
	Cloud-Clone Corp. Proteins for KLK7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0097209	epidermal lamellar body	IDA	15675955

KLK7 for ontologies About GeneDecksing

KLK7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for KLK7 (Kallikrein 7)
	OriGene Antibodies for KLK7 OriGene Custom Antibody Services for KLK7
	GenScript Custom Superior Antibodies Services for KLK7
	Novus Biologicals KLK7 Antibodies
	Abcam antibodies for KLK7
	Cloud-Clone Corp. Antibodies for KLK7
	ThermoFisher Antibodies for KLK7
	LSBio Antibodies in human, mouse, rat for KLK7

Assay Products for KLK7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for KLK7
	R&D Systems Proteome Profiler Antibody Arrays for KLK7 (Kallikrein 7)
	GenScript Custom Assay Services for KLK7
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for KLK7 Cloud-Clone Corp. CLIAs for KLK7

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

KLK: Kallikreins

PRSS: Serine peptidases / Serine peptidases

4 InterPro protein domains:

IPR001314 Peptidase_S1A

IPR009003 Trypsin-like_Pept_dom

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

Graphical View of Domain Structure for InterPro Entry P49862

ProtoNet protein and cluster: P49862

2 Blocks protein domains:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862

Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily

Similarity: Contains 1 peptidase S1 domain

KLK7 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KLK7_HUMAN, P49862

Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in

the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side

chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu- -Cys-7', '16-Tyr- -Leu-17', '25-Phe- -Tyr-26'

and '26-Tyr- -Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines

Catalytic activity: Cleavage of proteins with aromatic side chains in the P1 position

Enzyme regulation: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations

Induction: By estrogens and glucocorticoids in a breast carcinoma cell line

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.117¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008236	serine-type peptidase activity	TAS	8034709

KLK7 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK7

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLK7

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK7

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK7

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK7
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK7:
		hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
		SwitchGear 3'UTR luciferase reporter plasmid: KLK7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for KLK7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK7

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for KLK7
			Sirion Biotech Customized adenovirus for overexpression of KLK7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for KLK7 (see all 14) OriGene ORF clones in mouse, rat for KLK7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KLK7 (NM_005046)
		Sino Biological Human cDNA Clone for KLK7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK7
		Sirion Biotech Customized lentivirus for stable overexpression of KLK7 Customized lentivirus expression plasmids for stable overexpression of KLK7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLK7
		Search LifeMap BioReagents cell lines for KLK7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KLK7 About

See pathways by source

SuperPath

Contained pathways About

Collagen biosynthesis and modifying enzymes

Intrinsic Prothrombin Activation Pathway

0.40

Blood Coagulation Cascade

0.39

MSP-RON Signaling

MSP-RON Signaling

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK7

	MSP-RON Signaling
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLK7

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/7 Interacting proteins for KLK7 (P49862³ ENSP00000304791⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDSN	Q15517³, ENSP00000365465⁴	I2D: score=1 STRING: ENSP00000365465
ENSG00000137197	Q15517³	I2D: score=1
ENSG00000237114	Q15517³	I2D: score=1
ENSG00000237123	Q15517³	I2D: score=1
ENSG00000237165	Q15517³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0008544	epidermis development	TAS	8034709

KLK7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KLK7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLK7

1 DrugBank Compound for KLK7 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide	--	--	target	--	10592235

4 Novoseek inferred chemical compound relationships for KLK7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	75.2	48	7794273 (2), 8393902 (1), 7537777 (1), 11906548 (1) (see all 28)
retinoic acid	16.1	6	8105613 (3)
lipid	0	3	16117792 (1)
calcium	0	3	10616036 (1), 9665394 (1), 20090765 (1)

Search CenterWatch for drugs/clinical trials and news about KLK7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLK7 gene (4 alternative transcripts):

NM_001243126.1 NM_001207053.1 NM_005046.3 NM_139277.2

Unigene Cluster for KLK7:

Kallikrein-related peptidase 7

Hs.151254 [show with all ESTs]

Unigene Representative Sequence: NM_005046

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000304045(uc002pup.3 uc021uyj.1 uc010eok.3) ENST00000595820

ENST00000597707 ENST00000593904 ENST00000595638 ENST00000391807(uc002puo.3)

ENST00000336317

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK7
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK7:
		hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
		SwitchGear 3'UTR luciferase reporter plasmid: KLK7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for KLK7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK7

Clone Products:		OriGene clones in human, mouse for KLK7 (see all 14) OriGene ORF clones in mouse, rat for KLK7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KLK7 (NM_005046)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK7
		Sirion Biotech Customized lentivirus for stable overexpression of KLK7 Customized lentivirus expression plasmids for stable overexpression of KLK7

Primer Products:		OriGene qPCR primer pairs and template standards for KLK7 OriGene qSTAR qPCR primer pairs in human, mouse for KLK7
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KLK7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK7

Additional mRNA sequence:

AF411214.1 AF411215.1 AK289660.1 AK295313.1 AY601109.1 AY646152.1 BC032005.1 DQ018784.1

L33404.1

6 DOTS entries:

DT.97773710 DT.95100020 DT.443601 DT.100020915 DT.121475426 DT.95111488

24/61 AceView cDNA sequences (see all 61):

AU105241 AY646152 AA291764 AA425991 AF411215 NM_005046 AI049783 AF411214

NM_139277 BM839537 BM786551 BM798830 AW206700 BM828103 BM828060 BM759559

BI601676 BV189302 BM785808 BM752290 BM798621 BE713379 BM828167 BX103970

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KLK7 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	·	6c
SP1:									-
SP2:					-		-		-
SP3:									-		-
SP4:

ECgene alternative splicing isoforms for KLK7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLK7 expression in normal human tissues (normalized intensities) KLK7 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

KLK7 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/12 selected tissues (see all 12) fully expand


Epithelium
Human Corneal Epithelial Cells (HCEpiC)
esophageal epithelium

Eye (Sensory Organs) fully expand to see all 2 entries
Limbal epithelial stem cells
Human Corneal Epithelial Cells (HCEpiC)

Lung (Respiratory System) fully expand to see all 2 entries
Basal Cells Respiratory Bronchioles
Human Pulmonary Microvascular Endothelial Cells (HPMEC)

Epidermis (Integumentary System) fully expand to see all 2 entries
Corneocytes Stratified Epidermis
Human EpiDermal Keratinocytes-adult (HEK-a)

Esophagus (Gastrointestinal Tract)
esophageal epithelium

See KLK7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLK7

SOURCE GeneReport for Unigene cluster: Hs.151254

UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862

Tissue specificity: Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also

expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands,

uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage

serous carcinoma, compared with normal ovaries and benign adenomas (at protein level)

SABiosciences Custom PCR Arrays for KLK7

Primer Products:		OriGene qPCR primer pairs and template standards for KLK7 OriGene qSTAR qPCR primer pairs in human, mouse for KLK7
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KLK7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for KLK7 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Klk7^{1 , 5}	kallikrein related-peptidase 7 (chymotryptic, stratum more^{1, 5}	77.69(n)¹ 75.51(a)¹		7 (28.27 cM)⁵ 23993¹ NM_011872.2¹ NP_036002.1¹ 43811444⁵

ENSEMBL Gene Tree for KLK7 (if available)
TreeFam Gene Tree for KLK7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLK7 gene

KLK10² ENSG00000269741² KLK1² KLK4² PRSS37² KLK11² KLK14² KLK9²

KLK12² KLK13² KLK6² KLK2² KLK15² KLK5² PRSS1² PRSS58²

PRSS3² KLK8² KLK3²

18/83 SIMAP similar genes for KLK7 using alignment to 4 protein entries: KLK7_HUMAN (see all proteins) (see all similar genes):

KLK14 KLK8 KLK4 KLK1 KLK6 KLK9

PRSS1 KLK5 KLK2 TRY8 PRSS3 APS

KLK13 KLK11 KLK10 TRY6 KLK15 KLK12

KLK7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117302438^1,2	C,F	--	51479314(+)	`CTACCC/TGCTTC`	4	--	ds500¹ int¹		1		EA	120
rs113216294^1,2	C,F	--	51479368(+)	`TCTTCC/TTCCGG`	4	--	ds500¹ int¹		2		CSA	4
rs11084043^1,2	C,F,A,H	--	51479402(+)	`ACCCCC/TGTGGG`	4	--	ds500¹ int¹		20		NS EA NA CSA WA	2342
rs192764525^1,2		--	51479452(+)	`AAACCA/GCCAGC`	4	--	ds500¹ int¹		0	--	--	--	--
rs146239764^1,2		--	51479649(+)	`GGGCCA/GGCAGG`	4	--	ds500¹ int¹		0	--	--	--	--
rs184428524^1,2		--	51479701(+)	`CTTCCC/TGAAAG`	4	--	ds500¹ int¹		0	--	--	--	--
rs57392237^1,2	C,F	--	51479722(+)	`TCCAAT/CCTTAG`	4	--	ds500¹ int¹		5		WA CSA NA	243
rs139329452^1,2		--	51479749(+)	`CCCCAC/TCTTTA`	4	--	ut3¹		0	--	--	--	--
rs115353923^1,2	C,F	--	51479781(+)	`ACATTC/TAAGGA`	4	--	ut3¹		1		WA	118
rs268883^1,2	C,F,A	--	51480103(+)	`GACCAT/CGCTGG`	4	--	ut3¹ ese³		12		EA NA WA CSA	71

HapMap Linkage Disequilibrium report for KLK7 (51479729 - 51487355 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for KLK7: About this table

Variant ID	Type	Subtype	PubMed ID
esv2718763	CNV	Deletion	23290073
esv2718761	CNV	Deletion	23290073
esv2718760	CNV	Deletion	23290073
nsv513532	CNV	Insertion	21212237
esv1738203	OTHER	Inversion	17803354

Human Gene Mutation Database (HGMD): KLK7

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing KLK7

DNA2.0 Custom Variant and Variant Library Synthesis for KLK7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 604438 OMIM disorders: --

20/31 diseases for KLK7 (see all 31): About MalaCards

atopic dermatitis netherton syndrome dermatitis endocervicitis

skin disease cervical adenocarcinoma frontotemporal dementia eczema

psoriasis ovarian cancer oral squamous cell carcinoma dementia

esophageal cancer pancreatic ductal adenocarcinoma cervicitis meningioma

cervical cancer pancreatic cancer adenocarcinoma squamous cell carcinoma

3 diseases from the University of Copenhagen DISEASES database for KLK7:

Netherton syndrome Atopic dermatitis Carcinoma

KLK7 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/16 Novoseek inferred disease relationships for KLK7 gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
netherton syndrome	69.2	2	15679120 (1), 12834483 (1)
skin diseases	52	4	14609096 (2), 11874483 (1)
hyperkeratosis	49.4	2	14609096 (1), 15040472 (1)
dermatitis atopic	45.9	7	17989887 (3), 15191543 (3), 11874483 (1)
ovarian cancer	35.4	11	16916986 (3), 11906548 (1), 12738725 (1), 14764643 (1) (see all 5)
psoriasis	31	5	10335915 (3), 11874483 (1)
ovarian carcinoma	17.3	3	11906548 (1)
adenocarcinoma	9.67	4	17354228 (1), 19091121 (1), 15297163 (1), 15766562 (1)
carcinoma	5.68	4	10570434 (3), 12738725 (1)
breast carcinoma	5.42	1	14691584 (1)

Genetic Association Database (GAD): KLK7
Human Genome Epidemiology (HuGE) Navigator: KLK7 (8 documents)

Export disorders for KLK7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KLK7 gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with KLK7)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. (PubMed id 8034709)^{1, 2, 3, 9} Hansson L....Egelrud T. (1994)
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation. (PubMed id 10974542)^{1, 2, 9} Yousef G.M....Diamandis E.P. (2000)
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. (PubMed id 15191543)^{1, 4, 9} Vasilopoulos Y....Tazi-Ahnini R. (2004)
Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. (PubMed id 12738725)^{1, 2, 9} Dong Y.... Clements J.A. (2003)
Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. (PubMed id 17989887)^{1, 4, 9} Hubiche T....Boralevi F. (2007)
Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme. (PubMed id 7794273)^{1, 2, 9} Skytt A.... Egelrud T. (1995)
Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)^{1, 4} Klein R.J....Lilja H. (2010)
Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (2010)
Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (2010)
Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6). (PubMed id 18329042)^{1, 2} Fernandez I.S.... Romero A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5650	HGNC: 6368	AceView: KLK7	Ensembl:ENSG00000169035	euGenes: HUgn5650
ECgene: KLK7	H-InvDB: KLK7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KLK7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KLK7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for KLK7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KLK7 gene:
Search GeneIP for patents involving KLK7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for KLK7 (Kallikrein 7)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Recombinant/Natural Proteins for KLK7 (Kallikrein 7)
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Proteome Profiler Antibody Arrays for KLK7 (Kallikrein 7)

	OriGene Antibodies for KLK7		OriGene RNAi products in human, mouse, rat for KLK7
	OriGene qPCR primer pairs and template standards for KLK7		OriGene Protein Over-expression Lysate for KLK7
	OriGene MassSpec something-or-other for KLK7		OriGene clones in human, mouse for KLK7
	OriGene qSTAR qPCR primer pairs in human, mouse for KLK7		OriGene Purified Protein for KLK7
	OriGene ORF clones in mouse, rat for KLK7		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KLK7		OriGene Custom Protein Services for KLK7

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLK7
	QIAGEN SeqTarget long-range PCR primers for resequencing KLK7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK7

	GenScript Custom Purified and Recombinant Proteins Services for KLK7		GenScript cDNA clones with any tag delivered in your preferred vector for KLK7
	GenScript Custom Assay Services for KLK7		GenScript Custom Superior Antibodies Services for KLK7
	GenScript Custom overexpressing Cell Line Services for KLK7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KLK7 promoter
	Search Chromatin IP Primers for KLK7
	RT² qPCR Primer Assay in human, mouse, rat KLK7
	GNC Network for KLK7
	SABiosciences PCR Arrays including human, mouse, rat KLK7

Search Tocris compounds for KLK7

	Proteins and Antibodies for KLK7
	Cell Lysates for KLK7
	cDNA Clones for KLK7
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KLK7 antibodies
	KLK7 proteins
	KLK7 lysates

	Antibodies for KLK7
	See all of Abcam's Antibodies, Kits and Proteins for KLK7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for KLK7

	Proteins for KLK7
	Antibodies for KLK7
	ELISAs for KLK7
	CLIAs for KLK7

Search LifeMap BioReagents cell lines for KLK7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

	SwitchGear 3'UTR luciferase reporter plasmids for KLK7
	SwitchGear Promoter luciferase reporter plasmids for KLK7

ThermoFisher Antibodies for KLK7

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK7

	inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK7
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLK7

Customized:

	lentivirus for stable overexpression of KLK7
	lentivirus expression plasmids for stable overexpression of KLK7
	adenovirus for overexpression of KLK7

LSBio Antibodies in human, mouse, rat for KLK7

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KLK7 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

KLK7 Gene

Kallikrein-Related Peptidase 7

Aliases
for KLK7 gene

Summaries
for KLK7 gene

Genomic Views
for KLK7 gene

Proteins
for KLK7 gene

Protein Domains /
Families
for KLK7 gene

Function
for KLK7 gene

Pathways & Interactions
for KLK7 gene

Drugs & Compounds
for KLK7 gene

Transcripts
for KLK7 gene

Expression
for KLK7 gene

Orthologs
for KLK7 gene

Paralogs
for KLK7 gene

Genomic Variants
for KLK7 gene

Disorders / Diseases
for KLK7 gene

Publications
for KLK7 gene

External Searches for KLK7 gene

Genome Databases showing KLK7 gene

Other Databases showing KLK7 gene

Specialized Databases showing KLK7 gene

Intellectual Property
for KLK7 gene

Products
for KLK7 gene

View Random Gene

Advanced Search

Export list of displayed genes

KLK7 Gene

Kallikrein-Related Peptidase 7

Aliasesfor KLK7 gene

Summariesfor KLK7 gene

Genomic Viewsfor KLK7 gene

Proteinsfor KLK7 gene

Protein Domains /Familiesfor KLK7 gene

Functionfor KLK7 gene

Pathways & Interactionsfor KLK7 gene

Drugs & Compoundsfor KLK7 gene

Transcriptsfor KLK7 gene

Expression for KLK7 gene

Orthologsfor KLK7 gene

Paralogsfor KLK7 gene

Genomic Variantsfor KLK7 gene

Disorders / Diseasesfor KLK7 gene

Publicationsfor KLK7 gene

External Searches for KLK7 gene

Genome Databases showing KLK7 gene

Other Databases showing KLK7 gene

Specialized Databases showing KLK7 gene

Intellectual Propertyfor KLK7 gene

Productsfor KLK7 gene

View Random Gene

Aliases
for KLK7 gene

Summaries
for KLK7 gene

Genomic Views
for KLK7 gene

Proteins
for KLK7 gene

Protein Domains /
Families
for KLK7 gene

Function
for KLK7 gene

Pathways & Interactions
for KLK7 gene

Drugs & Compounds
for KLK7 gene

Transcripts
for KLK7 gene

Expression
for KLK7 gene

Orthologs
for KLK7 gene

Paralogs
for KLK7 gene

Genomic Variants
for KLK7 gene

Disorders / Diseases
for KLK7 gene

Publications
for KLK7 gene

Intellectual Property
for KLK7 gene

Products
for KLK7 gene