KLK7 Gene

Aliases
for KLK7 gene

Previous GC identifers: GC19M052110 GC19M051841 GC19M056155 GC19M056171 GC19M047813

Summaries
for KLK7 gene

Genomic Views
for KLK7 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: KLK7 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK7

KLK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051479:  view genomic region     (about GC identifiers)

Proteins
for KLK7 gene

5 PDB 3D structures from and Proteopedia for KLK7:

2QXG (3D)        2QXH (3D)        2QXI (3D)        2QXJ (3D)        3BSQ (3D)    

Explore the universe of human proteins at neXtProt for KLK7: NX_P49862

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for KLK7 (Kallikrein 7)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: KLK7 OriGene Protein Over-expression Lysate (see all 2): KLK7 OriGene Custom Protein Services for KLK7
	GenScript Custom Purified and Recombinant Proteins Services for KLK7
	Novus Biologicals KLK7 Proteins Novus Biologicals KLK7 Lysates
	Sino Biological Recombinant Protein for KLK7
	ProSpec Recombinant Protein for KLK7
	Uscn Proteins for KLK7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for KLK7 (Kallikrein 7)
	OriGene Antibodies: KLK7 OriGene Custom Antibody Services for KLK7
	GenScript Custom Superior Antibodies Services for KLK7
	Novus Biologicals KLK7 Antibodies
	Search for Antibodies for KLK7 at Abcam
	Uscn Antibodies for KLK7
	ThermoFisher Antibodies for KLK7

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for KLK7 (Kallikrein 7)
	GenScript Custom Assay Services for KLK7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK7

Protein Domains /
Families
for KLK7 gene

ProtoNet protein and cluster: P49862

Function
for KLK7 gene

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.117¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KLK7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK7
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK7:
		hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
		SwitchGear 3'UTR luciferase reporter plasmid: KLK7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK7 (see all 7) OriGene shRNA RFP: KLK7 OriGene siRNA: KLK7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK7

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KLK7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK7 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK7 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KLK7 (NM_005046)
		Sino Biological Human cDNA Clone for KLK7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLK7
		Search LifeMap BioReagents cell lines for KLK7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for KLK7 gene

	Super-pathway	contained gene-specific pathways
1	Blood Coagulation Cascade	Blood Coagulation Cascade 1.00 Intrinsic Prothrombin Activation Pathway 0.96
2	MSP-RON Signaling	MSP-RON Signaling 1.00

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK7

	MSP-RON Signaling
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for KLK7 gene

Transcripts
for KLK7 gene

Expression
for KLK7 gene

KLK7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LungRespiratory BronchiolesBasal Cells			Lung
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

Orthologs
for KLK7 gene

Paralogs
for KLK7 gene

Paralogs for KLK7 gene

KLK10²  KLK1²  KLK4²  PRSS37²  KLK11²  KLK14²  KLK9²  KLK12²  

KLK13²  KLK6²  KLK2²  KLK15²  KLK5²  PRSS1²  PRSS58²  PRSS3²  

KLK3²  KLK8²  

18/91 SIMAP similar genes for KLK7 using alignment to 4 protein entries:     KLK7_HUMAN (see all proteins) (see all similar genes):

KLK14    KLK4    KLK8    KLK5    KLK1    KLK6

KLK9    KLK11    KLK2    KLK13    TRY8    PRSS3

APS    PRSS1    KLK10    TRY6    KLK15    KLK12

KLK7 for paralogs           About GeneDecksing

Genomic Variants
for KLK7 gene

10/252 NCBI SNPs in KLK7 are shown (see all 252)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1173024381,2	F,	--	51479314(+)	CTACCC/TGCTTC	4	--	ds5001 int1		1		EA	120
rs1132162941,2	F,	--	51479368(+)	TCTTCC/TTCCGG	4	--	ds5001 int1		2		CSA	4
rs110840431,2	C,F,A,H,	--	51479402(+)	ACCCCC/TGTGGG	4	--	ds5001 int1		20		NS EA NA CSA WA	2342
rs1927645251,2		--	51479452(+)	AAACCA/GCCAGC	4	--	int1 ds5001		0	--	--	--	--
rs1462397641,2		--	51479649(+)	GGGCCA/GGCAGG	4	--	ds5001 int1		0	--	--	--	--
rs1844285241,2		--	51479701(+)	CTTCCC/TGAAAG	4	--	ds5001 int1		0	--	--	--	--
rs573922371,2	C,F,	--	51479722(+)	TCCAAT/CCNNNN	4	--	ds5001 int1		5		WA CSA NA	243
rs1393294521,2		--	51479749(+)	CCCCAC/TCTTTA	4	--	ut31		0	--	--	--	--
rs1153539231,2	F,	--	51479781(+)	ACATTC/TAAGGA	4	--	ut31		1		WA	118
rs2688831,2	C,F,A,	--	51480103(+)	GACCAT/CGCTGG	4	--	ut31 ese3		12		EA NA WA CSA	71

HapMap Linkage Disequilibrium report for KLK7 (51479729 - 51487320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KLK7: --
Human Gene Mutation Database (HGMD): KLK7

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK7

DNA2.0 Custom Variant and Variant Library Synthesis for KLK7

Disorders / Diseases
for KLK7 gene

20/35 diseases for KLK7

10/16 Novoseek disease relationships for KLK7 gene (see all 16)    About this table

Publications
for KLK7 gene

PubMed articles for KLK7 gene, integrated from 9 sources (see all 108): (articles sorted by number of sources associating them with KLK7)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. (PubMed id 8034709)^{1, 2, 3, 9} Hansson L....Egelrud T. (1994)
2. The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation. (PubMed id 10974542)^{1, 2, 9} Yousef G.M....Diamandis E.P. (2000)
3. Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. (PubMed id 15191543)^{1, 4, 9} Vasilopoulos Y....Tazi-Ahnini R. (2004)
4. Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. (PubMed id 12738725)^{1, 2, 9} Dong Y.... Clements J.A. (2003)
5. Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme. (PubMed id 7794273)^{1, 2, 9} Skytt A.... Egelrud T. (1995)
6. Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6). (PubMed id 18329042)^{1, 2} Fernandez I.S.... Romero A. (2008)
7. Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7. (PubMed id 17909180)^{1, 2} Debela M.... Goettig P. (2007)
8. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)^{1, 3} (2006)
9. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)^{1, 3} Lundwall A....Yousef G.M. (2006)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

External Searches for KLK7 gene

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Products
for KLK7 gene