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KLK7 Gene

protein-coding   GIFtS: 63
GCID: GC19M051479

Kallikrein-Related Peptidase 7

(Previous names: kallikrein 7 (chymotryptic, stratum corneum))
(Previous symbol: PRSS6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 71 2     kallikrein-72
PRSS61 2 3 5     Signal Protein2
SCCE2 3 5     EC 3.4.21.1173
Kallikrein 7 (Chymotryptic, Stratum Corneum)1 2     hSCCE3
Serine Protease 62 3     LKL75
Stratum Corneum Chymotryptic Enzyme2 3     EC 3.4.218
hK72 3     

External Ids:    HGNC: 63681   Entrez Gene: 56502   Ensembl: ENSG000001690357   OMIM: 6044385   UniProtKB: P498623   

Export aliases for KLK7 gene to outside databases

Previous GC identifers: GC19M052110 GC19M051841 GC19M056155 GC19M056171 GC19M047813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK7 Gene:
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse
physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has
chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes
desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer
invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and
progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic
dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. (provided
by RefSeq, May 2011)

GeneCards Summary for KLK7 Gene:
KLK7 (kallikrein-related peptidase 7) is a protein-coding gene. Diseases associated with KLK7 include atopic dermatitis, and endocervicitis. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862
Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in
the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side
chains in the P1 position. Cleaves insulin A chain at '14-Tyr- -Gln-15' and insulin B chain at '6-Leu- -Cys-7',
'16-Tyr- -Leu-17', '25-Phe- -Tyr-26' and '26-Tyr- -Thr-27'. Could play a role in the activation of precursors to
inflammatory cytokines

Gene Wiki entry for KLK7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK7 gene promoter:
         MZF-1   MEF-2A   HEN1   aMEF-2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK7 promoter sequence
   Search Chromatin IP Primers for KLK7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051479:  view genomic region     (about GC identifiers)

Start:
51,479,729 bp from pter      End:
51,487,355 bp from pter
Size:
7,627 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862 (See protein sequence)
Recommended Name: Kallikrein-7 precursor  
Size: 253 amino acids; 27525 Da
5 PDB 3D structures from and Proteopedia for KLK7:
2QXG (3D)        2QXH (3D)        2QXI (3D)        2QXJ (3D)        3BSQ (3D)    
Secondary accessions: A8K0U5 Q8N5N9 Q8NFV7
Alternative splicing: 2 isoforms:  P49862-1   P49862-2   

Explore the universe of human proteins at neXtProt for KLK7: NX_P49862

Explore proteomics data for KLK7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn246
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KLK7 (P49862) (see all 5)
     GDSGGPL  VLTAAHC  SGGPLVC  WVLTAAH 


    See KLK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001230055.1  NP_001193982.1  NP_005037.1  NP_644806.1  

    ENSEMBL proteins: 
     ENSP00000304791   ENSP00000470538   ENSP00000469950   ENSP00000470084   ENSP00000375683  
     ENSP00000337540  
    Reactome Protein details: P49862

    KLK7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P49862

    ProtoNet protein and cluster: P49862

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK7_HUMAN, P49862
    Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in
    the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side
    chains in the P1 position. Cleaves insulin A chain at '14-Tyr- -Gln-15' and insulin B chain at '6-Leu- -Cys-7',
    '16-Tyr- -Leu-17', '25-Phe- -Tyr-26' and '26-Tyr- -Thr-27'. Could play a role in the activation of precursors to
    inflammatory cytokines
    Catalytic activity: Cleavage of proteins with aromatic side chains in the P1 position
    Enzyme regulation: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12
    Induction: By estrogens and glucocorticoids in a breast carcinoma cell line

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1171

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS8034709
         
    KLK7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK7
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    hsa-mir-335-5p (MIRT018481)

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    3 qRT-PCR Assays for microRNAs that regulate KLK7:
    hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLK7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLK7

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    GenScript: all cDNA clones in your preferred vector (see all 2): KLK7 (NM_005046)
    Sino Biological Human cDNA Clone for KLK7
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK7_HUMAN, P49862: Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and
    in cytoplasm at the invasive front
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0097209epidermal lamellar body IDA15675955

    KLK7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3MSP-RON Signaling
    MSP-RON Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK7
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway


    1 Reactome Pathway for KLK7
        Degradation of the extracellular matrix



    KLK7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK7
    Interactions:

        GeneGlobe Interaction Network for KLK7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for KLK7 (P498623 ENSP000003047914) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDSNQ155173, ENSP000003654654I2D: score=1 STRING: ENSP00000365465
    ENSG00000137197Q155173I2D: score=1 
    ENSG00000237114Q155173I2D: score=1 
    ENSG00000237123Q155173I2D: score=1 
    ENSG00000237165Q155173I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008544epidermis development TAS8034709
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    KLK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK7

    1 DrugBank Compound for KLK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide-- --target--10592235

    4 Novoseek inferred chemical compound relationships for KLK7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 75.2 48 7794273 (2), 8393902 (1), 7537777 (1), 11906548 (1) (see all 28)
    retinoic acid 16.1 6 8105613 (3)
    lipid 0 3 16117792 (1)
    calcium 0 3 10616036 (1), 9665394 (1), 20090765 (1)



    KLK7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLK7 gene (4 alternative transcripts): 
    NM_001243126.1  NM_001207053.1  NM_005046.3  NM_139277.2  

    Unigene Cluster for KLK7:

    Kallikrein-related peptidase 7
    Hs.151254  [show with all ESTs]
    Unigene Representative Sequence: NM_005046
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304045(uc002pup.3 uc021uyj.1 uc010eok.3) ENST00000595820
    ENST00000597707 ENST00000593904 ENST00000595638 ENST00000391807(uc002puo.3)
    ENST00000336317

    miRNA
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    hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLK7 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK7
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    Additional mRNA sequence: 

    AF411214.1 AF411215.1 AK289660.1 AK295313.1 AY601109.1 AY646152.1 BC032005.1 DQ018784.1 
    L33404.1 

    6 DOTS entries:

    DT.97773710  DT.95100020  DT.443601  DT.100020915  DT.121475426  DT.95111488 

    Selected AceView cDNA sequences (see all 61):

    AY646152 AF411214 AU105241 NM_005046 AA291764 AF411215 AA425991 AI049783 
    NM_139277 BM844044 BX103970 AI819857 BM798830 BM762588 AU134435 BM751385 
    BM828103 AW134828 BM839537 BM980496 BM828148 BM752290 BM785808 BM761132 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KLK7    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                                       
    SP2:              -     -     -                                       
    SP3:                          -     -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for KLK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK7 expression in normal human tissues (normalized intensities)      KLK7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLK7 Expression
    About this image


    KLK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal epithelial stem cells (family)
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
    KLK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151254

    UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862
    Tissue specificity: Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also
    expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands,
    uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage
    serous carcinoma, compared with normal ovaries and benign adenomas (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat KLK7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK7 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk71 , 5 kallikrein related-peptidase 7 (chymotryptic, stratum more1, 5 78.16(n)1
    75.86(a)1
      7 (28.27 cM)5
    239931  NM_011872.21  NP_036002.11 
     438114445 


    ENSEMBL Gene Tree for KLK7 (if available)
    TreeFam Gene Tree for KLK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK7 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK142  KLK92  
    KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK7 using alignment to 3 protein entries:     KLK7_HUMAN (see all proteins) (see all similar genes):
    KLK14    KLK8    KLK4    KLK1    KLK5    KLK2
    KLK9    KLK6    PRSS1    APS    KLK13    PRSS3
    TRY8    KLK10    PRSS2    KLK12    KLK11    KLK3

    KLK7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK7 (see all 315)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1173024381,2
    C,F--51479314(+) CTACCC/TGCTTC 4 -- ds5001 int11Minor allele frequency- T:0.03EA 120
    rs1132162941,2
    C,F--51479368(+) TCTTCC/TTCCGG 4 -- ds5001 int12Minor allele frequency- T:0.50CSA 4
    rs110840431,2
    C,F,A,H--51479402(+) ACCCCC/TGTGGG 4 -- ds5001 int120Minor allele frequency- T:0.42NS EA NA CSA WA 2342
    rs1927645251,2
    --51479452(+) AAACCA/GCCAGC 4 -- ds5001 int10--------
    rs1462397641,2
    --51479649(+) GGGCCA/GGCAGG 4 -- ds5001 int10--------
    rs1844285241,2
    --51479701(+) CTTCCC/TGAAAG 4 -- ds5001 int10--------
    rs573922371,2
    C,F--51479722(+) TCCAAT/CCTTAG 4 -- ds5001 int15Minor allele frequency- C:0.20WA CSA NA 243
    rs1393294521,2
    --51479749(+) CCCCAC/TCTTTA 4 -- ut310--------
    rs1153539231,2
    C,F--51479781(+) ACATTC/TAAGGA 4 -- ut311Minor allele frequency- T:0.07WA 118
    rs2688831,2
    C,F,A--51480103(+) GACCAT/CGCTGG 4 -- ut31 ese312Minor allele frequency- C:0.14EA NA WA CSA 71

    HapMap Linkage Disequilibrium report for KLK7 (51479729 - 51487355 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KLK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718763CNV Deletion23290073
    esv2718761CNV Deletion23290073
    esv2718760CNV Deletion23290073
    nsv513532CNV Insertion21212237
    esv1738203OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): KLK7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK7
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604438    OMIM disorders: --

    Selected diseases for KLK7 (see all 32):    About MalaCards
    atopic dermatitis    endocervicitis    dermatitis    netherton syndrome
    skin disease    cervical adenocarcinoma    pancreatic ductal adenocarcinoma    frontotemporal dementia
    psoriasis    ovarian cancer    oral squamous cell carcinoma    childhood leukemia
    dementia    cervicitis    esophageal cancer    meningioma
    bronchiolitis    adenocarcinoma    cervical cancer    pancreatitis

    3 diseases from the University of Copenhagen DISEASES database for KLK7:
    Netherton syndrome     Atopic dermatitis     Carcinoma

    KLK7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for KLK7 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    netherton syndrome 69.2 2 15679120 (1), 12834483 (1)
    skin diseases 52 4 14609096 (2), 11874483 (1)
    hyperkeratosis 49.4 2 14609096 (1), 15040472 (1)
    dermatitis atopic 45.9 7 17989887 (3), 15191543 (3), 11874483 (1)
    ovarian cancer 35.4 11 16916986 (3), 11906548 (1), 12738725 (1), 14764643 (1) (see all 5)
    psoriasis 31 5 10335915 (3), 11874483 (1)
    ovarian carcinoma 17.3 3 11906548 (1)
    adenocarcinoma 9.67 4 17354228 (1), 19091121 (1), 15297163 (1), 15766562 (1)
    carcinoma 5.68 4 10570434 (3), 12738725 (1)
    breast carcinoma 5.42 1 14691584 (1)

    Genetic Association Database (GAD): KLK7
    Human Genome Epidemiology (HuGE) Navigator: KLK7 (8 documents)

    Export disorders for KLK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK7 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with KLK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. (PubMed id 8034709)1, 2, 3, 9 Hansson L....Egelrud T. (J. Biol. Chem. 1994)
    2. The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation. (PubMed id 10974542)1, 2, 9 Yousef G.M....Diamandis E.P. (Gene 2000)
    3. Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. (PubMed id 15191543)1, 4, 9 Vasilopoulos Y....Tazi-Ahnini R. (J. Invest. Dermatol. 2004)
    4. Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. (PubMed id 12738725)1, 2, 9 Dong Y.... Clements J.A. (Clin. Cancer Res. 2003)
    5. Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. (PubMed id 17989887)1, 4, 9 Hubiche T....Boralevi F. (Acta Derm. Venereol. 2007)
    6. Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme. (PubMed id 7794273)1, 2, 9 Skytt A.... Egelrud T. (Biochem. Biophys. Res. Commun. 1995)
    7. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    9. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    10. Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6). (PubMed id 18329042)1, 2 Fernandez I.S.... Romero A. (J. Mol. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5650 HGNC: 6368 AceView: KLK7 Ensembl:ENSG00000169035 euGenes: HUgn5650
    ECgene: KLK7 H-InvDB: KLK7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK7 gene:
    Search GeneIP for patents involving KLK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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