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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK7 Gene

protein-coding   GIFtS: 60
GCID: GC19M051479

Kallikrein-Related Peptidase 7

(Previous names: kallikrein 7 (chymotryptic, stratum corneum))
(Previous symbol: PRSS6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 71 2     hK72 3
PRSS61 2 3     kallikrein-72
Kallikrein 7 (Chymotryptic, Stratum Corneum)1 2     Signal Protein2
Serine Protease 62 3     EC 3.4.21.1173
Stratum Corneum Chymotryptic Enzyme2 3     hSCCE3
SCCE2 3     EC 3.4.218

External Ids:    HGNC: 63681   Entrez Gene: 56502   Ensembl: ENSG000001690357   OMIM: 6044385   UniProtKB: P498623   

Export aliases for KLK7 gene to outside databases

Previous GC identifers: GC19M052110 GC19M051841 GC19M056155 GC19M056171 GC19M047813


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK7 Gene:
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse
physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has
chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes
desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer
invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and
progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic
dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. (provided
by RefSeq, May 2011)

GeneCards Summary for KLK7 Gene: 
KLK7 (kallikrein-related peptidase 7) is a protein-coding gene. Diseases associated with KLK7 include atopic dermatitis, and netherton syndrome, and among its related super-pathways are Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862
Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in
the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side
chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu- -Cys-7', '16-Tyr- -Leu-17', '25-Phe- -Tyr-26'
and '26-Tyr- -Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines

Gene Wiki entry for KLK7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK7 gene promoter:
         MZF-1   MEF-2A   HEN1   aMEF-2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051479:  view genomic region     (about GC identifiers)

Start:
51,479,729 bp from pter      End:
51,487,355 bp from pter
Size:
7,627 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862 (See protein sequence)
Recommended Name: Kallikrein-7 precursor  
Size: 253 amino acids; 27525 Da
Subcellular location: Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and
in cytoplasm at the invasive front
5 PDB 3D structures from and Proteopedia for KLK7:
2QXG (3D)        2QXH (3D)        2QXI (3D)        2QXJ (3D)        3BSQ (3D)    
Secondary accessions: Q8N5N9 Q8NFV7
Alternative splicing: 2 isoforms:  P49862-1   P49862-2   

Explore the universe of human proteins at neXtProt for KLK7: NX_P49862

Explore proteomics data for KLK7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49862

  • 4/5 DME Specific Peptides for KLK7 (P49862) (see all 5)
     GDSGGPL  VLTAAHC  SGGPLVC  WVLTAAH 

    KLK7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLK7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001230055.1  NP_001193982.1  NP_005037.1  NP_644806.1  

    ENSEMBL proteins: 
     ENSP00000304791   ENSP00000470538   ENSP00000469950   ENSP00000470084   ENSP00000375683  
     ENSP00000337540  

    Human Recombinant Protein Products for KLK7: 
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    Sino Biological Recombinant Protein for KLK7
    Sino Biological Cell Lysate for KLK7 
    ProSpec Recombinant Protein for KLK7
    Cloud-Clone Corp. Proteins for KLK7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0097209epidermal lamellar body IDA15675955

    KLK7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KLK: Kallikreins
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P49862

    ProtoNet protein and cluster: P49862

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK7_HUMAN, P49862
    Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in
    the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side
    chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu- -Cys-7', '16-Tyr- -Leu-17', '25-Phe- -Tyr-26'
    and '26-Tyr- -Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines
    Catalytic activity: Cleavage of proteins with aromatic side chains in the P1 position
    Enzyme regulation: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations
    Induction: By estrogens and glucocorticoids in a breast carcinoma cell line

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1171

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS8034709
         
    KLK7 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK7 
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    hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLK7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLK7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.40
    Blood Coagulation Cascade0.39
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK7
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLK7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for KLK7 (P498623 ENSP000003047914) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDSNQ155173, ENSP000003654654I2D: score=1 STRING: ENSP00000365465
    ENSG00000137197Q155173I2D: score=1 
    ENSG00000237114Q155173I2D: score=1 
    ENSG00000237123Q155173I2D: score=1 
    ENSG00000237165Q155173I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0008544epidermis development TAS8034709

    KLK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLK7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLK7

    1 DrugBank Compound for KLK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide-- --target--10592235

    4 Novoseek inferred chemical compound relationships for KLK7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 75.2 48 7794273 (2), 8393902 (1), 7537777 (1), 11906548 (1) (see all 28)
    retinoic acid 16.1 6 8105613 (3)
    lipid 0 3 16117792 (1)
    calcium 0 3 10616036 (1), 9665394 (1), 20090765 (1)

    Search CenterWatch for drugs/clinical trials and news about KLK7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLK7 gene (4 alternative transcripts): 
    NM_001243126.1  NM_001207053.1  NM_005046.3  NM_139277.2  

    Unigene Cluster for KLK7:

    Kallikrein-related peptidase 7
    Hs.151254  [show with all ESTs]
    Unigene Representative Sequence: NM_005046
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304045(uc002pup.3 uc021uyj.1 uc010eok.3) ENST00000595820
    ENST00000597707 ENST00000593904 ENST00000595638 ENST00000391807(uc002puo.3)
    ENST00000336317

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK7:
    hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLK7 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK7

    Additional mRNA sequence: 

    AF411214.1 AF411215.1 AK289660.1 AK295313.1 AY601109.1 AY646152.1 BC032005.1 DQ018784.1 
    L33404.1 

    6 DOTS entries:

    DT.97773710  DT.95100020  DT.443601  DT.100020915  DT.121475426  DT.95111488 

    24/61 AceView cDNA sequences (see all 61):

    AU105241 AY646152 AA291764 AA425991 AF411215 NM_005046 AI049783 AF411214 
    NM_139277 BM839537 BM786551 BM798830 AW206700 BM828103 BM828060 BM759559 
    BI601676 BV189302 BM785808 BM752290 BM798621 BE713379 BM828167 BX103970 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KLK7    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                                       
    SP2:              -     -     -                                       
    SP3:                          -     -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for KLK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLK7 expression in normal human tissues (normalized intensities)      KLK7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLK7 Expression
    About this image


    KLK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Epithelium
             Human Corneal Epithelial Cells (HCEpiC)   
             esophageal epithelium   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal epithelial stem cells
             Human Corneal Epithelial Cells (HCEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
             Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Corneocytes Stratified Epidermis
             Human EpiDermal Keratinocytes-adult (HEK-a)   
     
     Esophagus (Gastrointestinal Tract)
             esophageal epithelium   

    See KLK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLK7

    SOURCE GeneReport for Unigene cluster: Hs.151254

    UniProtKB/Swiss-Prot: KLK7_HUMAN, P49862
    Tissue specificity: Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also
    expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands,
    uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage
    serous carcinoma, compared with normal ovaries and benign adenomas (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK7 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk71 , 5 kallikrein related-peptidase 7 (chymotryptic, stratum more1, 5 77.69(n)1
    75.51(a)1
      7 (28.27 cM)5
    239931  NM_011872.21  NP_036002.11 
     438114445 


    ENSEMBL Gene Tree for KLK7 (if available)
    TreeFam Gene Tree for KLK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLK7 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK142  KLK92  
    KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    18/83 SIMAP similar genes for KLK7 using alignment to 4 protein entries:     KLK7_HUMAN (see all proteins) (see all similar genes):
    KLK14    KLK8    KLK4    KLK1    KLK6    KLK9
    PRSS1    KLK5    KLK2    TRY8    PRSS3    APS
    KLK13    KLK11    KLK10    TRY6    KLK15    KLK12

    KLK7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/315 SNPs in KLK7 are shown (see all 315)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1173024381,2
    C,F--51479314(+) CTACCC/TGCTTC 4 -- ds5001 int11Minor allele frequency- T:0.03EA 120
    rs1132162941,2
    C,F--51479368(+) TCTTCC/TTCCGG 4 -- ds5001 int12Minor allele frequency- T:0.50CSA 4
    rs110840431,2
    C,F,A,H--51479402(+) ACCCCC/TGTGGG 4 -- ds5001 int120Minor allele frequency- T:0.42NS EA NA CSA WA 2342
    rs1927645251,2
    --51479452(+) AAACCA/GCCAGC 4 -- ds5001 int10--------
    rs1462397641,2
    --51479649(+) GGGCCA/GGCAGG 4 -- ds5001 int10--------
    rs1844285241,2
    --51479701(+) CTTCCC/TGAAAG 4 -- ds5001 int10--------
    rs573922371,2
    C,F--51479722(+) TCCAAT/CCTTAG 4 -- ds5001 int15Minor allele frequency- C:0.20WA CSA NA 243
    rs1393294521,2
    --51479749(+) CCCCAC/TCTTTA 4 -- ut310--------
    rs1153539231,2
    C,F--51479781(+) ACATTC/TAAGGA 4 -- ut311Minor allele frequency- T:0.07WA 118
    rs2688831,2
    C,F,A--51480103(+) GACCAT/CGCTGG 4 -- ut31 ese312Minor allele frequency- C:0.14EA NA WA CSA 71

    HapMap Linkage Disequilibrium report for KLK7 (51479729 - 51487355 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KLK7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718763CNV Deletion23290073
    esv2718761CNV Deletion23290073
    esv2718760CNV Deletion23290073
    nsv513532CNV Insertion21212237
    esv1738203OTHER Inversion17803354


    Human Gene Mutation Database (HGMD): KLK7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK7
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604438    OMIM disorders: --

    20/31 diseases for KLK7 (see all 31):    About MalaCards
    atopic dermatitis    netherton syndrome    dermatitis    endocervicitis
    skin disease    cervical adenocarcinoma    frontotemporal dementia    eczema
    psoriasis    ovarian cancer    oral squamous cell carcinoma    dementia
    esophageal cancer    pancreatic ductal adenocarcinoma    cervicitis    meningioma
    cervical cancer    pancreatic cancer    adenocarcinoma    squamous cell carcinoma

    3 diseases from the University of Copenhagen DISEASES database for KLK7:
    Netherton syndrome     Atopic dermatitis     Carcinoma

    KLK7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/16 Novoseek inferred disease relationships for KLK7 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    netherton syndrome 69.2 2 15679120 (1), 12834483 (1)
    skin diseases 52 4 14609096 (2), 11874483 (1)
    hyperkeratosis 49.4 2 14609096 (1), 15040472 (1)
    dermatitis atopic 45.9 7 17989887 (3), 15191543 (3), 11874483 (1)
    ovarian cancer 35.4 11 16916986 (3), 11906548 (1), 12738725 (1), 14764643 (1) (see all 5)
    psoriasis 31 5 10335915 (3), 11874483 (1)
    ovarian carcinoma 17.3 3 11906548 (1)
    adenocarcinoma 9.67 4 17354228 (1), 19091121 (1), 15297163 (1), 15766562 (1)
    carcinoma 5.68 4 10570434 (3), 12738725 (1)
    breast carcinoma 5.42 1 14691584 (1)

    Genetic Association Database (GAD): KLK7
    Human Genome Epidemiology (HuGE) Navigator: KLK7 (8 documents)

    Export disorders for KLK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLK7 gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with KLK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. (PubMed id 8034709)1, 2, 3, 9 Hansson L....Egelrud T. (1994)
    2. The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation. (PubMed id 10974542)1, 2, 9 Yousef G.M....Diamandis E.P. (2000)
    3. Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. (PubMed id 15191543)1, 4, 9 Vasilopoulos Y....Tazi-Ahnini R. (2004)
    4. Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. (PubMed id 12738725)1, 2, 9 Dong Y.... Clements J.A. (2003)
    5. Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. (PubMed id 17989887)1, 4, 9 Hubiche T....Boralevi F. (2007)
    6. Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme. (PubMed id 7794273)1, 2, 9 Skytt A.... Egelrud T. (1995)
    7. Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (2010)
    8. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    9. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    10. Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6). (PubMed id 18329042)1, 2 Fernandez I.S.... Romero A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5650 HGNC: 6368 AceView: KLK7 Ensembl:ENSG00000169035 euGenes: HUgn5650
    ECgene: KLK7 H-InvDB: KLK7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLK7 gene:
    Search GeneIP for patents involving KLK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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