KLK7 Gene

Aliases
for KLK7 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19M052110 GC19M051841 GC19M056155 GC19M056171 GC19M047813

Summaries
for KLK7 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for KLK7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NC_018930.2  NT_011109.17  

SwitchGear Promoter luciferase reporter plasmid: KLK7 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK7

KLK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051479:  view genomic region     (about GC identifiers)

Proteins
for KLK7 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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5 PDB 3D structures from and Proteopedia for KLK7:

2QXG (3D)        2QXH (3D)        2QXI (3D)        2QXJ (3D)        3BSQ (3D)    

Explore the universe of human proteins at neXtProt for KLK7: NX_P49862

Explore proteomics data for KLK7 at MOPED

Post-translational modifications: 

KLK7 Human Recombinant Protein Products:

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	antibodies-online proteins for KLK7 (21 products)
	antibodies-online peptides for KLK7

KLK7 Antibody Products:

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Domains /
Families
for KLK7 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P49862

Find genes that share domains with KLK7           About GenesLikeMe

Function
for KLK7 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.117¹

     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for KLK7

miRNA Products:		miRTarBase miRNAs that target KLK7: hsa-mir-335-5p (MIRT018481)
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		hsa-miR-3915 hsa-miR-512-3p hsa-miR-509-3p
		SwitchGear 3'UTR luciferase reporter plasmid: KLK7 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat KLK7

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KLK7

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		GenScript: all cDNA clones in your preferred vector (see all 2): KLK7 (NM_005046)
		Sino Biological Human cDNA Clone for KLK7
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK7

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		Browse ESI BIO Cell Lines and PureStem Progenitors for KLK7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

Localization
for KLK7 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
cytoskeleton	1
nucleus	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for KLK7 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for KLK7 About     See pathways by source

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	SuperPath	Contained pathways About
1	Collagen biosynthesis and modifying enzymes	Intrinsic Prothrombin Activation Pathway 0.39 Blood Coagulation Cascade 0.38
2	Degradation of the extracellular matrix	Degradation of the extracellular matrix 0.43 Extracellular matrix organization 0.34
3	MSP-RON Signaling	MSP-RON Signaling

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK7

	MSP-RON Signaling
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

1 Reactome Pathway for KLK7

Degradation of the extracellular matrix

Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for KLK7 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for KLK7 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for KLK7 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KLK7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Eye (Sensory Organs)    fully expand to see all 2 entries
Limbal epithelial stem cells (family)
Lung (Respiratory System)
Basal Cells Respiratory Bronchioles

Primer Products:		OriGene qPCR primer pairs and template standards for KLK7 OriGene qSTAR qPCR primer pairs in human, mouse for KLK7
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLK7
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK7

Orthologs
for KLK7 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for KLK7 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for KLK7 gene

KLK10²  ENSG00000269741²  KLK1²  KLK4²  PRSS37²  KLK11²  KLK14²  KLK9²  

KLK12²  KLK13²  KLK6²  KLK2²  KLK15²  KLK5²  PRSS1²  PRSS58²  

PRSS3²  KLK8²  KLK3²  

Selected SIMAP similar genes for KLK7 using alignment to 3 protein entries:     KLK7_HUMAN (see all proteins) (see all similar genes):

KLK14    KLK8    KLK4    KLK1    KLK5    KLK2

KLK9    KLK6    PRSS1    APS    KLK13    PRSS3

TRY8    KLK10    PRSS2    KLK12    KLK11    KLK3

Find genes that share paralogs with KLK7           About GenesLikeMe

Genomic Variants
for KLK7 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KLK7 (see all 315)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1173024381,2	C,F	--	51479314(+)	CTACCC/TGCTTC	4	--	ds5001 int1		1		EA	120
rs1132162941,2	C,F	--	51479368(+)	TCTTCC/TTCCGG	4	--	ds5001 int1		2		CSA	4
rs110840431,2	C,F,A,H	--	51479402(+)	ACCCCC/TGTGGG	4	--	ds5001 int1		20		NS EA NA CSA WA	2342
rs1927645251,2		--	51479452(+)	AAACCA/GCCAGC	4	--	ds5001 int1		0	--	--	--	--
rs1462397641,2		--	51479649(+)	GGGCCA/GGCAGG	4	--	ds5001 int1		0	--	--	--	--
rs1844285241,2		--	51479701(+)	CTTCCC/TGAAAG	4	--	ds5001 int1		0	--	--	--	--
rs573922371,2	C,F	--	51479722(+)	TCCAAT/CCTTAG	4	--	ds5001 int1		5		WA CSA NA	243
rs1393294521,2		--	51479749(+)	CCCCAC/TCTTTA	4	--	ut31		0	--	--	--	--
rs1153539231,2	C,F	--	51479781(+)	ACATTC/TAAGGA	4	--	ut31		1		WA	118
rs2688831,2	C,F,A	--	51480103(+)	GACCAT/CGCTGG	4	--	ut31 ese3		12		EA NA WA CSA	71

HapMap Linkage Disequilibrium report for KLK7 (51479729 - 51487355 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for KLK7:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2718763	CNV	Deletion	23290073
esv2718761	CNV	Deletion	23290073
esv2718760	CNV	Deletion	23290073
nsv513532	CNV	Insertion	21212237
esv1738203	OTHER	Inversion	17803354

Human Gene Mutation Database (HGMD): KLK7

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KLK7

DNA2.0 Custom Variant and Variant Library Synthesis for KLK7

Disorders / Diseases
for KLK7 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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4 diseases for KLK7

Selected Novoseek inferred disease relationships for KLK7 gene (see all 16)    About this table

Publications
for KLK7 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KLK7 gene, integrated from 10 sources (see all 112): (articles sorted by number of sources associating them with KLK7)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. (PubMed id 8034709)^{1, 2, 3, 9} Hansson L....Egelrud T. (J. Biol. Chem. 1994)
2. The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation. (PubMed id 10974542)^{1, 2, 9} Yousef G.M....Diamandis E.P. (Gene 2000)
3. Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. (PubMed id 15191543)^{1, 4, 9} Vasilopoulos Y....Tazi-Ahnini R. (J. Invest. Dermatol. 2004)
4. Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. (PubMed id 12738725)^{1, 2, 9} Dong Y.... Clements J.A. (Clin. Cancer Res. 2003)
5. Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. (PubMed id 17989887)^{1, 4, 9} Hubiche T....Boralevi F. (Acta Derm. Venereol. 2007)
6. Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme. (PubMed id 7794273)^{1, 2, 9} Skytt A.... Egelrud T. (Biochem. Biophys. Res. Commun. 1995)
7. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)^{1, 4} Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
9. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
10. Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6). (PubMed id 18329042)^{1, 2} Fernandez I.S.... Romero A. (J. Mol. Biol. 2008)

External Searches for KLK7 gene

Genome Databases showing KLK7 gene

Other Databases showing KLK7 gene

Specialized Databases showing KLK7 gene

Products
for KLK7 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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