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KLK6 Gene

protein-coding   GIFtS: 62
GCID: GC19M051461

Kallikrein-Related Peptidase 6

(Previous names: protease, serine, 18, kallikrein 6 (neurosin, zyme))
(Previous symbols: PRSS9, PRSS18)
  See KLK6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 61 2     Klk72
PRSS91 2 3 5     hK62
PRSS181 2 3     kallikrein-62
Protease M2 3     neurosin2
Serine Protease 182 3     zyme2
Serine Protease 92 3     EC 3.4.21.-3
SP592 3     Neurosin3
Kallikrein 6 (Neurosin, Zyme)1     Zyme3
Protease, Serine, 181     ZYME5
Bssp2     EC 3.4.218

External Ids:    HGNC: 63671   Entrez Gene: 56532   Ensembl: ENSG000001677557   OMIM: 6026525   UniProtKB: Q928763   

Export aliases for KLK6 gene to outside databases

Previous GC identifers: GC19M052090 GC19M051823 GC19M056137 GC19M056153 GC19M047795


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK6 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate
amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's
disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLK6 Gene:
KLK6 (kallikrein-related peptidase 6) is a protein-coding gene. Diseases associated with KLK6 include spinal cord injury, and ovarian cancer. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
Function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or
Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein
and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades
alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of
Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal
cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a
role in invasion and metastasis

Gene Wiki entry for KLK6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK6 gene promoter:
         AREB6   NF-kappaB2   Nkx2-5   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLK6 promoter sequence
   Search Chromatin IP Primers for KLK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3

KLK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051461:  view genomic region     (about GC identifiers)

Start:
51,461,887 bp from pter      End:
51,472,929 bp from pter
Size:
11,043 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876 (See protein sequence)
Recommended Name: Kallikrein-6 precursor  
Size: 244 amino acids; 26856 Da
Mass spectrometry: Mass=25866; Method=MALDI; Range=22-244; Source=PubMed:11983703;
5 PDB 3D structures from and Proteopedia for KLK6:
1GVL (3D)        1L2E (3D)        1LO6 (3D)        3VFE (3D)        4D8N (3D)    
Secondary accessions: A6NJA1 A8MW09 Q6H301
Alternative splicing: 3 isoforms:  Q92876-1   Q92876-2   Q92876-3   

Explore the universe of human proteins at neXtProt for KLK6: NX_Q92876

Explore proteomics data for KLK6 at MOPED

Post-translational modifications: 

  • Inactivated by autolytic cleavage after Arg-801
  • Glycosylation2 at Asn134
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KLK6 (Q92876) (see all 6)
     GDSGGPL  VLTAAHC  SGGPLVC  WVLTAAH 


    See KLK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012982.1  NP_001012983.1  NP_002765.1  

    ENSEMBL proteins: 
     ENSP00000366047   ENSP00000309148   ENSP00000469630   ENSP00000470482   ENSP00000471948  
     ENSP00000469702   ENSP00000366049   ENSP00000375684   ENSP00000409241   ENSP00000396012  

    KLK6 Human Recombinant Protein Products:

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    Novus Biologicals KLK6 Lysates
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    Sino Biological Cell Lysate for KLK6
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    Cloud-Clone Corp. Proteins for KLK6

     
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    KLK6 Assay Products:

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    Search eBioscience for ELISAs for KLK6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q92876

    ProtoNet protein and cluster: Q92876

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with KLK6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK6_HUMAN, Q92876
    Function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or
    Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein
    and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades
    alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of
    Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal
    cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a
    role in invasion and metastasis
    Enzyme regulation: Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor,
    benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan
    sulfate, heparan sulfate and heparin
    Biophysicochemical properties: Kinetic parameters: KM=1562 uM for Tosyl-Gly-Pro-Arg-AMC; KM=777 uM for
    Tosyl-Gly-Pro-Lys-AMC; KM=0.410 mM for Phe-Ser-Arg-AMC; KM=0.455 mM for Gly-Gly-Arg-AMC; KM=0.335 mM for
    Asp-Pro-Arg-AMC; KM=0.758 mM for Gln-Gly-Arg-AMC; KM=0.625 mM for Pro-Phe-Arg-AMC; KM=0.271 mM for
    Val-Pro-Arg-AMC; KM=1.72 mM for Val-Leu-Lys-AMC;
    Induction: By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive
    astrocytes

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS12878203
    GO:0005515protein binding IPI12709365
    GO:0008233peptidase activity ----
         
    Find genes that share ontologies with KLK6           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Klk6):
     homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with KLK6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK6

    miRNA
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    miRTarBase miRNAs that target KLK6:
    hsa-let-7f-5p (MIRT004678)

    Block miRNA regulation of human, mouse, rat KLK6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLK6
    SwitchGear 3'UTR luciferase reporter plasmidKLK6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLK6

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    GenScript: all cDNA clones in your preferred vector (see all 3): KLK6 (NM_002774)
    Sino Biological Human cDNA Clone for KLK6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK6_HUMAN, Q92876: Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected
    in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and
    microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion5
    nucleus5
    endoplasmic reticulum3
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11668196
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with KLK6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK6 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2MSP-RON Signaling
    MSP-RON Signaling
    3Alpha-synuclein signaling
    Alpha-synuclein signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK6
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    1 BioSystems Pathway for KLK6
        Alpha-synuclein signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK6
    Interactions:

        GeneGlobe Interaction Network for KLK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for KLK6 (Q928763 ENSP000003091484) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINF2P086973, ENSP000003218534I2D: score=2 STRING: ENSP00000321853
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    CSN1S1P477103, ENSP000002468914I2D: score=1 STRING: ENSP00000246891
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--
    GO:0007417central nervous system development NAS12589961
    GO:0009611response to wounding NAS12016211
    GO:0010975regulation of neuron projection development IEA--
    GO:0016540protein autoprocessing NAS12878203

    Find genes that share ontologies with KLK6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK6

    1 HMDB Compound for KLK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    DermatanChondroitin sulfate B (see all 13)24967-94-0--

    1 DrugBank Compound for KLK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423

    3 Novoseek inferred chemical compound relationships for KLK6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 70.1 39 10997858 (2), 11388408 (2), 9003450 (2), 15299321 (2) (see all 25)
    steroid 30.7 2 10675891 (1), 16897430 (1)
    calcium 0 3 15305371 (1), 16800746 (1), 15299321 (1)



    Find genes that share compounds with KLK6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLK6 gene (4 alternative transcripts): 
    NM_001012964.1  NM_001012965.1  NM_002774.3  NM_001012966.1  

    Unigene Cluster for KLK6:

    Kallikrein-related peptidase 6
    Hs.79361  [show with all ESTs]
    Unigene Representative Sequence: NM_002774
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376851(uc002pui.3 uc010ycn.2) ENST00000310157(uc010eoj.3 uc002puh.3 uc002pul.3 uc002pum.3)
    ENST00000597379 ENST00000594641 ENST00000599881 ENST00000599690 ENST00000376853
    ENST00000391808(uc002puj.3) ENST00000456750 ENST00000424910
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      QuantiTect SYBR Green Assays in human, mouse, rat KLK6
      QuantiFast Probe-based Assays in human, mouse, rat KLK6

    Additional mRNA sequence: 

    AF013988.1 AK314897.1 AY279383.1 AY318867.1 AY318868.1 AY318869.1 AY318870.1 AY457039.1 
    BC015525.2 BT006852.1 D78203.1 DQ223012.1 U62801.1 

    7 DOTS entries:

    DT.97854762  DT.100752295  DT.101983443  DT.100752293  DT.91715397  DT.121475439  DT.91639926 

    Selected AceView cDNA sequences (see all 189):

    CR608439 BC015525 AA444380 BM847505 AA293231 U54605 AY318869 AY318867 
    BX103658 AI339533 AA477689 AI538200 AA293027 CB154539 BM761500 BM843144 
    BI597604 BM762240 AA292334 BM844718 BM829876 BP355472 BM762512 F06420 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLK6 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:        -     -           -                                             
    SP2:        -     -           -           -                                 
    SP3:                          -                                             
    SP4:                          -           -                                 
    SP5:                          -     -                                       


    ECgene alternative splicing isoforms for KLK6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCAATAA
    KLK6 Expression
    About this image


    KLK6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal epithelial stem cells (family)
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Spinal Cord (Nervous System)
     
     Stomach (Gastrointestinal Tract)
    KLK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79361

    UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
    Tissue specificity: In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid,
    nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and
    breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in
    glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary
    and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis,
    pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein
    level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions.
    Overexpressed in primary breast tumors but not expressed in metastatic tumors

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK6 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk61 , 5 kallikrein related-peptidase 61, 5 75(n)1
    68.44(a)1
      7 (28.28 cM)5
    191441  NM_001164696.11  NP_001158168.11 
     438244995 


    ENSEMBL Gene Tree for KLK6 (if available)
    TreeFam Gene Tree for KLK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK6 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK6 using alignment to 4 protein entries:     KLK6_HUMAN (see all proteins) (see all similar genes):
    KLK4    KLK11    KLK8    KLK2    PRSS1    KLK15
    PRSS2    KLK13    TRY8    PRSS3    KLK7    KLK9
    KLK14    KLK1    KLK3    APS    CFD    DF

    Find genes that share paralogs with KLK6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK6 (see all 372)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883243361,2
    --51461622(+) AGGGAA/GGAGAA 3 -- ds50010--------
    rs1924815491,2
    --51461662(+) GTGAGC/GCGAGA 3 -- ds50010--------
    rs1845312271,2
    --51461676(+) CGCCAC/TTGCAC 3 -- ds50010--------
    rs1483331021,2
    C--51461759(+) GAGGTA/C/GTAGCA 3 -- ds50010--------
    rs1906768751,2
    --51461913(+) ATTGAG/TTGCAT 3 -- ut310--------
    rs1815262031,2
    --51461914(+) TTGAGC/TGCATG 3 -- ut310--------
    rs2013588461,2
    C--51461971(+) ATCTTC/TCCAAC 3 -- ut310--------
    rs1404920141,2
    C--51462100(+) AGACAA/C/TGTGGC 6 -- ut310--------
    rs1853911801,2
    --51462220(+) GTCCTC/TACTCA 3 -- ut310--------
    rs1895040821,2
    C--51462230(+) ATCACA/GTCCTC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for KLK6 (51461887 - 51472929 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLK6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK6
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602652    OMIM disorders: --

    2 diseases for KLK6:    
    About MalaCards
    spinal cord injury    ovarian cancer

    2 diseases from the University of Copenhagen DISEASES database for KLK6:
    Ovarian cancer     Netherton syndrome

    Find genes that share disorders with KLK6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KLK6 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 58.1 29 12633763 (4), 15305183 (4), 16864975 (3), 8898378 (2) (see all 11)
    ovarian carcinoma 44.4 6 11124344 (3), 11054022 (1), 19707197 (1)
    carcinoma papillary 41.3 2 15867230 (2)
    alzheimers disease 30 11 10997858 (2), 18525128 (2), 18620574 (1), 12589961 (1) (see all 7)
    testicular cancer 29.6 1 15911097 (1)
    prostate cancer 27.2 3 12218299 (1), 14696124 (1), 12142373 (1)
    cancer 22.7 6 10675891 (1), 12439719 (1), 14696124 (1), 18627290 (1) (see all 5)
    senile plaques 22.5 1 10997858 (1)
    parkinson disease 21.9 4 10997858 (2), 18358605 (1), 17965832 (1)
    tumors 20.9 26 11054022 (4), 12633763 (3), 16864975 (2), 14633706 (1) (see all 11)

    Genetic Association Database (GAD): KLK6
    Human Genome Epidemiology (HuGE) Navigator: KLK6 (24 documents)

    Export disorders for KLK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK6 gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with KLK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. (PubMed id 9003450)1, 2, 3, 9 Yamashiro K.... Yamaguchi N. (Biochim. Biophys. Acta 1997)
    2. Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease. (PubMed id 10610719)1, 2, 9 Yousef G.M.... Diamandis E.P. (Genomics 1999)
    3. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. (PubMed id 11668196)1, 2, 9 Petraki C.D.... Diamandis E.P. (J. Histochem. Cytochem. 2001)
    4. Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells. (PubMed id 15557757)1, 2, 9 Ghosh M.C....Diamandis E.P. (Tumor Biol. 2004)
    5. A novel protease homolog differentially expressed in breast and ovarian cancer. (PubMed id 8898378)1, 2, 9 Anisowicz A.... Sager R. (Mol. Med. 1996)
    6. Cloning and characterization of novel isoforms of the human kallikrein 6 gene. (PubMed id 15207701)1, 2, 9 Pampalakis G.... Sotiropoulou G. (Biochem. Biophys. Res. Commun. 2004)
    7. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. (PubMed id 12928483)1, 2, 9 Iwata A....Nukina N. (Hum. Mol. Genet. 2003)
    8. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5653 HGNC: 6367 AceView: KLK6 Ensembl:ENSG00000167755 euGenes: HUgn5653
    ECgene: KLK6 H-InvDB: KLK6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK6 gene:
    Search GeneIP for patents involving KLK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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