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Aliases for KLK6 Gene

Aliases for KLK6 Gene

  • Kallikrein-Related Peptidase 6 2 3
  • PRSS9 3 4 6
  • Zyme 3 4 6
  • Serine Protease 18 3 4
  • Serine Protease 9 3 4
  • Protease M 3 4
  • Neurosin 3 4
  • PRSS18 3 4
  • SP59 3 4
  • Kallikrein 6 (Neurosin, Zyme) 2
  • Protease, Serine, 18 2
  • Kallikrein-6 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Bssp 3
  • Klk7 3
  • HK6 3

External Ids for KLK6 Gene

Previous HGNC Symbols for KLK6 Gene

  • PRSS9
  • PRSS18

Previous GeneCards Identifiers for KLK6 Gene

  • GC19M052090
  • GC19M051823
  • GC19M056137
  • GC19M056153
  • GC19M051461
  • GC19M047795

Summaries for KLK6 Gene

Entrez Gene Summary for KLK6 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK6 Gene

KLK6 (Kallikrein-Related Peptidase 6) is a Protein Coding gene. Diseases associated with KLK6 include synucleinopathy and spinal cord injury. Among its related pathways are Alpha-synuclein signaling and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK6 Gene

  • Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Gene Wiki entry for KLK6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK6 Gene

Genomics for KLK6 Gene

Regulatory Elements for KLK6 Gene

Genomic Location for KLK6 Gene

Start:
50,958,631 bp from pter
End:
50,969,673 bp from pter
Size:
11,043 bases
Orientation:
Minus strand

Genomic View for KLK6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK6 Gene

Proteins for KLK6 Gene

  • Protein details for KLK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92876-KLK6_HUMAN
    Recommended name:
    Kallikrein-6
    Protein Accession:
    Q92876
    Secondary Accessions:
    • A6NJA1
    • A8MW09
    • Q6H301

    Protein attributes for KLK6 Gene

    Size:
    244 amino acids
    Molecular mass:
    26856 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLK6 Gene

    Alternative splice isoforms for KLK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK6 Gene

Proteomics data for KLK6 Gene at MOPED

Selected DME Specific Peptides for KLK6 Gene

Post-translational modifications for KLK6 Gene

Antibody Products

  • R&D Systems Antibodies for KLK6 (Kallikrein 6/Neurosin)

Protein Products

Domains for KLK6 Gene

Gene Families for KLK6 Gene

HGNC:
  • KLK :Kallikreins
  • PRSS :Serine peptidases / Serine peptidases

Suggested Antigen Peptide Sequences for KLK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92876

UniProtKB/Swiss-Prot:

KLK6_HUMAN :
  • Q92876
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK6: view

Function for KLK6 Gene

Molecular function for KLK6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1562 uM for Tosyl-Gly-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=777 uM for Tosyl-Gly-Pro-Lys-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.410 mM for Phe-Ser-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.455 mM for Gly-Gly-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.335 mM for Asp-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.758 mM for Gln-Gly-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.625 mM for Pro-Phe-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.271 mM for Val-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=1.72 mM for Val-Leu-Lys-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.
UniProtKB/Swiss-Prot Function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
UniProtKB/Swiss-Prot Induction: By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive astrocytes.

Enzyme Numbers (IUBMB) for KLK6 Gene

Gene Ontology (GO) - Molecular Function for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 12878203
GO:0005515 protein binding IPI 12709365
GO:0008233 peptidase activity --
genes like me logo Genes that share ontologies with KLK6: view

Phenotypes for KLK6 Gene

genes like me logo Genes that share phenotypes with KLK6: view

Animal Model Products

CRISPR Products

miRNA for KLK6 Gene

miRTarBase miRNAs that target KLK6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for KLK6 Gene

Localization for KLK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK6 Gene

Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK6 Gene COMPARTMENTS Subcellular localization image for KLK6 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 11668196
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with KLK6: view

Pathways for KLK6 Gene

genes like me logo Genes that share pathways with KLK6: view

Pathways by source for KLK6 Gene

1 BioSystems pathway for KLK6 Gene

Gene Ontology (GO) - Biological Process for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0007417 central nervous system development NAS 12589961
GO:0009611 response to wounding NAS 12016211
GO:0010975 regulation of neuron projection development IEA --
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with KLK6: view

Compounds for KLK6 Gene

(1) HMDB Compounds for KLK6 Gene

Compound Synonyms Cas Number PubMed IDs
Dermatan
  • Chondroitin sulfate B
24967-94-0

(1) Drugbank Compounds for KLK6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Benzamidine
618-39-3 target

(3) Novoseek inferred chemical compound relationships for KLK6 Gene

Compound -log(P) Hits PubMed IDs
serine 70.1 29
steroid 30.7 2
calcium 0 3
genes like me logo Genes that share compounds with KLK6: view

Transcripts for KLK6 Gene

Unigene Clusters for KLK6 Gene

Kallikrein-related peptidase 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - -

Relevant External Links for KLK6 Gene

GeneLoc Exon Structure for
KLK6
ECgene alternative splicing isoforms for
KLK6

Expression for KLK6 Gene

mRNA expression in normal human tissues for KLK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (16.5), Brain - Substantia nigra (8.4), and Esophagus - Mucosa (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLK6 Gene

SOURCE GeneReport for Unigene cluster for KLK6 Gene Hs.79361

mRNA Expression by UniProt/SwissProt for KLK6 Gene

Q92876-KLK6_HUMAN
Tissue specificity: In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
genes like me logo Genes that share expressions with KLK6: view

In Situ Assay Products

Orthologs for KLK6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK6 35
  • 83.61 (n)
  • 80.33 (a)
KLK6 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK6 35
  • 87.84 (n)
  • 85.66 (a)
KLK6 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk6 35
  • 75 (n)
  • 68.44 (a)
Klk6 16
Klk6 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLK6 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk6 35
  • 75.27 (n)
  • 66.8 (a)
Species with no ortholog for KLK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK6 Gene

ENSEMBL:
Gene Tree for KLK6 (if available)
TreeFam:
Gene Tree for KLK6 (if available)

Paralogs for KLK6 Gene

genes like me logo Genes that share paralogs with KLK6: view

Variants for KLK6 Gene

Sequence variations from dbSNP and Humsavar for KLK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs268890 -- 50,971,418(-) GGGAT(C/T)CTGGT upstream-variant-2KB
rs268891 -- 50,968,727(-) GGGGG(G/T)GTGTG utr-variant-5-prime, intron-variant
rs268892 -- 50,968,682(-) CCTGC(A/G/T)TCCTC utr-variant-5-prime, intron-variant
rs1654533 -- 50,971,170(-) AGTGA(C/T)GGGGG upstream-variant-2KB
rs1654534 -- 50,971,164(-) GGGGG(A/G)TGCAC upstream-variant-2KB

Relevant External Links for KLK6 Gene

HapMap Linkage Disequilibrium report
KLK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLK6 Gene

Disorders for KLK6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for KLK6 Gene including...

Search for KLK6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for KLK6 Gene

(16) Novoseek inferred disease relationships for KLK6 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 58.1 22
ovarian carcinoma 44.4 5
carcinoma papillary 41.3 2
alzheimers disease 30 9
testicular cancer 29.6 1

Relevant External Links for KLK6

Genetic Association Database (GAD)
KLK6
Human Genome Epidemiology (HuGE) Navigator
KLK6
genes like me logo Genes that share disorders with KLK6: view

No data available for UniProtKB/Swiss-Prot for KLK6 Gene

Publications for KLK6 Gene

  1. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. (PMID: 9003450) Yamashiro K. … Yamaguchi N. (Biochim. Biophys. Acta 1997) 2 3 4 23
  2. A novel protease homolog differentially expressed in breast and ovarian cancer. (PMID: 8898378) Anisowicz A. … Sager R. (Mol. Med. 1996) 3 4 23
  3. Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease. (PMID: 10610719) Yousef G.M. … Diamandis E.P. (Genomics 1999) 3 4 23
  4. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. (PMID: 11668196) Petraki C.D. … Diamandis E.P. (J. Histochem. Cytochem. 2001) 3 4 23
  5. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. (PMID: 12928483) Iwata A. … Nukina N. (Hum. Mol. Genet. 2003) 3 4 23

Products for KLK6 Gene

Sources for KLK6 Gene

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