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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK6 Gene

protein-coding   GIFtS: 61
GCID: GC19M051461

kallikrein-related peptidase 6

(Previous names: protease, serine, 18, kallikrein 6 (neurosin, zyme) )
(Previous symbols: PRSS9, PRSS18)
 Explore 35 diseases affiliated with
KLK6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLK6    

Aliases
for KLK6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kallikrein-Related Peptidase 61 2     Kallikrein 6 (Neurosin, Zyme)1
PRSS91 2 3 5     Protease, Serine, 181
PRSS181 2 3     HK61
Bssp1 2     Kallikrein-61
Klk71 2     Zyme3
Neurosin3     EC 3.4.21.-3
Protease M2 3     Neurosin3
Serine Protease 182 3     Zyme3
Serine Protease 92 3     ZYME5
SP592 3     EC 3.4.218

External Ids:    HGNC: 63671   Entrez Gene: 56532   Ensembl: ENSG000001677557   OMIM: 6026525   UniProtKB: Q928763   

Export aliases for KLK6 gene to outside databases

Previous GC identifers: GC19M052090 GC19M051823 GC19M056137 GC19M056153 GC19M047795


Summaries
for KLK6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLK6:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that
many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The
encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate
amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's
disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for
this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
Function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro
in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and
extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and
prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other
synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated
with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis

Gene Wiki entry for KLK6


Genomic Views
for KLK6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK6 gene promoter:
         AREB6   NF-kappaB2   Nkx2-5   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLK6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3

KLK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051461:  view genomic region     (about GC identifiers)

Start:
 51,461,887 bp from pter      End:
 51,472,929 bp from pter
Size:
 11,043 bases      Orientation:
 minus strand

Proteins
for KLK6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876 (See protein sequence)
Recommended Name: Kallikrein-6 precursor  
Size: 244 amino acids; 26856 Da
Subcellular location: Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the
nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal
fractions of HEK-293 cells and released into the cytoplasm following cell stress
Mass spectrometry: Mass=25866; Method=MALDI; Range=22-244; Source=PubMed:11983703;
5 PDB 3D structures from and Proteopedia for KLK6:
1GVL (3D)        1L2E (3D)        1LO6 (3D)        3VFE (3D)        4D8N (3D)    
Secondary accessions: A6NJA1 A8MW09 Q6H301
Alternative splicing: 3 isoforms:  Q92876-1   Q92876-2   Q92876-3   

Explore the universe of human proteins at neXtProt for KLK6: NX_Q92876

Post-translational modifications:

  • Inactivated by autolytic cleavage after Arg-801
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92876

    • 4/6 DME Specific Peptides for KLK6 (Q92876) (see all 6)
     GDSGGPL  VLTAAHC  SGGPLVC  WVLTAAH 

    KLK6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012982.1  NP_001012983.1  NP_002765.1  

    ENSEMBL proteins: 
     ENSP00000366049   ENSP00000309148   ENSP00000366047   ENSP00000375684   ENSP00000409241  
     ENSP00000396012  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: KLK6
    OriGene Protein Over-expression Lysate (see all 4): KLK6
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    Novus Biologicals KLK6 Proteins
    Novus Biologicals KLK6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLK6

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11668196
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA11668196
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--


    KLK6 for ontologies           About GeneDecksing



    KLK6 Antibody Products: 
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    Uscn Antibodies for KLK6
    ThermoFisher Antibodies for KLK6

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    Uscn ELISAs and CLIAs for KLK6

    Protein Domains /
    Families
    for KLK6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLK6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q92876

    ProtoNet protein and cluster: Q92876

    2 Blocks protein families:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    Function
    for KLK6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
    Function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro
    in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and
    extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and
    prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other
    synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated
    with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis
    Enzyme regulation: Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine
    and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan
    sulfate and heparin
    Biophysicochemical properties: Kinetic parameters: KM=1562 uM for Tosyl-Gly-Pro-Arg-AMC; KM=777 uM for
    Tosyl-Gly-Pro-Lys-AMC; KM=0.410 mM for Phe-Ser-Arg-AMC; KM=0.455 mM for Gly-Gly-Arg-AMC; KM=0.335 mM for
    Asp-Pro-Arg-AMC; KM=0.758 mM for Gln-Gly-Arg-AMC; KM=0.625 mM for Pro-Phe-Arg-AMC; KM=0.271 mM for Val-Pro-Arg-AMC;
    KM=1.72 mM for Val-Leu-Lys-AMC;
    Induction: By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive
    astrocytes

    Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

    miRNA
    Products:            		miRTarBase miRNAs that target KLK6:
    hsa-let-7f (MIRT004678)

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    SwitchGear 3'UTR luciferase reporter plasmid: KLK6 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: KLK6
    OriGene siRNA: KLK6
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): KLK6 (NM_002774)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK6 

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    Search LifeMap BioReagents cell lines for KLK6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK6

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity NAS12878203
    GO:0005515protein binding IPI12878203


    KLK6 for ontologies           About GeneDecksing



    Pathways & Interactions
    for KLK6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Blood Coagulation Cascade
    		Blood Coagulation Cascade1.00
    		Intrinsic Prothrombin Activation Pathway0.96
    2MSP-RON Signaling
    		MSP-RON Signaling1.00
    3Alpha-synuclein signaling
    		Alpha-synuclein signaling1.00

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK6
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    1 BioSystems Pathway for KLK6 
        Alpha-synuclein signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for KLK6 (Q928763 ENSP000003091484) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINF2P086973, ENSP000003218534I2D: score=2 STRING: ENSP00000321853
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    CSN1S1P477103, ENSP000002468914I2D: score=1 STRING: ENSP00000246891
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007417central nervous system development NAS12589961
    GO:0009611response to wounding NAS12016211
    GO:0010975regulation of neuron projection development IEA--
    GO:0016540protein autoprocessing NAS12878203


    KLK6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLK6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLK6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLK6

    1 HMDB Compound for KLK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    DermatanChondroitin sulfate B (see all 13)24967-94-0--

    1 DrugBank Compound for KLK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423

    3 Novoseek chemical compound relationships for KLK6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 70.1 39 10997858 (2), 11388408 (2), 9003450 (2), 15299321 (2) (see all 25)
    steroid 30.7 2 10675891 (1), 16897430 (1)
    calcium 0 3 15305371 (1), 16800746 (1), 15299321 (1)

    Search CenterWatch for drugs/clinical trials and news about KLK6 

    Transcripts
    for KLK6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLK6 gene (4 alternative transcripts): 
    NM_001012964.1  NM_001012965.1  NM_002774.3  NM_001012966.1  

    Unigene Cluster for KLK6:

    Kallikrein-related peptidase 6
    Hs.79361  [show with all ESTs]
    Unigene Representative Sequence: NM_002774
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376853 ENST00000310157(uc010eoj.3 uc002puh.3 uc002pul.3 uc002pum.3)
    ENST00000376851(uc002pui.3 uc010ycn.2) ENST00000391808(uc002puj.3)
    ENST00000456750 ENST00000424910

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
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    Inhib. RNA
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    OriGene shRNA RFP: KLK6
    OriGene siRNA: KLK6
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): KLK6 (NM_002774)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK6 
    Primer
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    Additional cDNA sequence: 

    AF013988.1 AK314897.1 AY279383.1 AY318867.1 AY318868.1 AY318869.1 AY318870.1 AY457039.1 
    BC015525.2 BT006852.1 D78203.1 DQ223012.1 U62801.1 

    7 DOTS entries:

    DT.97854762  DT.100752295  DT.101983443  DT.100752293  DT.91715397  DT.121475439  DT.91639926 

    24/189 AceView cDNA sequences (see all 189):

    BX103658 CR608439 AA293027 AY318867 AA293231 AA444380 AY318869 AA477689 
    AI538200 AI339533 U54605 CB154539 BC015525 BM847505 BP348550 AW016426 
    BP347907 BI752107 BM762685 BM763500 AY318868 BI755676 AA394115 BM842911 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KLK6 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:        -     -           -                                             
    SP2:        -     -           -           -                                 
    SP3:                          -                                             
    SP4:                          -           -                                 
    SP5:                          -     -                                       


    ECgene alternative splicing isoforms for KLK6

    Expression
    for KLK6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACTCAATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KLK6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KLK6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLK6

    SOURCE GeneReport for Unigene cluster: Hs.79361

    UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
    Tissue specificity: In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple
    aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor
    cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such
    as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in
    skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary,
    adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological
    inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not
    expressed in metastatic tumors

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK6

    Orthologs
    for KLK6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KLK6 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 41(a)
    39(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 GL343276.1(1578128-1583778)
    GL343276.1(1637722-1647419)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:663826
    si:ch73-103b2.36
    		 si:ch73-103b2.3
    		 40(a)
    39(a)
    		 many ↔ many
    many ↔ many
    		 16(28253006-28254288)
    16(28257799-28259131)


    ENSEMBL Gene Tree for KLK6 (if available)
    TreeFam Gene Tree for KLK6 (if available) 

    Paralogs
    for KLK6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLK6 gene
    KLK102  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  KLK92  
    KLK122  KLK132  KLK22  KLK152  KLK52  PRSS12  PRSS582  PRSS32  
    KLK32  KLK82  
    18/95 SIMAP similar genes for KLK6 using alignment to 4 protein entries:     KLK6_HUMAN (see all proteins) (see all similar genes):
    KLK4    KLK11    KLK8    PRSS1    KLK13    TRY6
    PRSS2    TRY8    PRSS3    KLK15    KLK2    KLK7
    KLK9    KLK14    KLK1    APS    CFD    DF

    KLK6 for paralogs           About GeneDecksing



    Genomic Variants
    for KLK6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 NCBI SNPs in KLK6 are shown (see all 286)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1883243361,2
    		--51461622(+) AGGGAA/GGAGAA 3 -- ds50010--------
    rs1924815491,2
    		--51461662(+) GTGAGC/GCGAGA 3 -- ds50010--------
    rs1845312271,2
    		--51461676(+) CGCCAC/TTGCAC 3 -- ds50010--------
    rs1483331021,2
    		--51461759(+) GAGGTA/CTAGCA 3 -- ds50010--------
    rs1906768751,2
    		--51461913(+) ATTGAG/TTGCAT 3 -- ut310--------
    rs1815262031,2
    		--51461914(+) TTGAGC/TGCATG 3 -- ut310--------
    rs2013588461,2
    		C--51461971(+) ATCTTC/TCCAAC 3 -- ut310--------
    rs1404920141,2
    		--51462100(+) AGACAA/CGTGGC 3 -- ut310--------
    rs1853911801,2
    		--51462220(+) GTCCTC/TACTCA 3 -- ut310--------
    rs1895040821,2
    		--51462230(+) ATCACA/GTCCTC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for KLK6 (51461887 - 51472929 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLK6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK6
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK6

    Disorders / Diseases
    for KLK6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLK6 for disorders           About GeneDecksing

    OMIM gene information: 602652    OMIM disorders: --

    20/35 diseases for KLK6 (see all 35):    About MalaCards
    alzheimer's disease    spinal cord injury    netherton syndrome    pancreatic ductal adenocarcinoma
    testicular cancer    transsexualism    ovarian cancer    breast-ovarian cancer
    vascular dementia    epithelial ovarian cancer    parkinson's disease    breast cyst
    renal cell carcinoma    ovarian carcinoma    papillary carcinoma    multiple sclerosis
    dementia    psoriasis    skin disease    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for KLK6:
    Ovarian cancer     Netherton syndrome

    10/16 Novoseek disease relationships for KLK6 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 58.1 29 12633763 (4), 15305183 (4), 16864975 (3), 8898378 (2) (see all 11)
    ovarian carcinoma 44.4 6 11124344 (3), 11054022 (1), 19707197 (1)
    carcinoma papillary 41.3 2 15867230 (2)
    alzheimers disease 30 11 10997858 (2), 18525128 (2), 18620574 (1), 12589961 (1) (see all 7)
    testicular cancer 29.6 1 15911097 (1)
    prostate cancer 27.2 3 12218299 (1), 14696124 (1), 12142373 (1)
    cancer 22.7 6 10675891 (1), 12439719 (1), 14696124 (1), 18627290 (1) (see all 5)
    senile plaques 22.5 1 10997858 (1)
    parkinson disease 21.9 4 10997858 (2), 18358605 (1), 17965832 (1)
    tumors 20.9 26 11054022 (4), 12633763 (3), 16864975 (2), 14633706 (1) (see all 11)

    Human Genome Epidemiology (HuGE) Navigator: KLK6 (24 documents)

    Export disorders for KLK6 gene to outside databases

    Publications
    for KLK6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLK6 gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with KLK6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. (PubMed id 9003450)1, 2, 3, 9 Yamashiro K.... Yamaguchi N. (1997)
    2. Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease. (PubMed id 10610719)1, 2, 9 Yousef G.M.... Diamandis E.P. (1999)
    3. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. (PubMed id 11668196)1, 2, 9 Petraki C.D.... Diamandis E.P. (2001)
    4. Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells. (PubMed id 15557757)1, 2, 9 Ghosh M.C....Diamandis E.P. (2004)
    5. A novel protease homolog differentially expressed in breast and ovarian cancer. (PubMed id 8898378)1, 2, 9 Anisowicz A.... Sager R. (1996)
    6. Cloning and characterization of novel isoforms of the human kallikrein 6 gene. (PubMed id 15207701)1, 2, 9 Pampalakis G.... Sotiropoulou G. (2004)
    7. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. (PubMed id 12928483)1, 2, 9 Iwata A....Nukina N. (2003)
    8. Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects. (PubMed id 16321973)1, 2 Angelo P.F.... Juliano M.A. (2006)
    9. Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. (PubMed id 16800739)1, 2 Pampalakis G. and Sotiropoulou G. (2006)
    10. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)

    External Searches for KLK6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing KLK6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5653 HGNC: 6367 AceView: KLK6 Ensembl:ENSG00000167755 euGenes: HUgn5653
    ECgene: KLK6 H-InvDB: KLK6

    Other Databases showing KLK6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLK6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KLK6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLK6 gene:
    Search GeneIP for patents involving KLK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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