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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK6 Gene

protein-coding   GIFtS: 62
GCID: GC19M051461

Kallikrein-Related Peptidase 6

(Previous names: protease, serine, 18, kallikrein 6 (neurosin, zyme))
(Previous symbols: PRSS9, PRSS18)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 61 2     Klk72
PRSS91 2 3 5     hK62
PRSS181 2 3     kallikrein-62
Protease M2 3     neurosin2
Serine Protease 182 3     zyme2
Serine Protease 92 3     EC 3.4.21.-3
SP592 3     Neurosin3
Kallikrein 6 (Neurosin, Zyme)1     Zyme3
Protease, Serine, 181     ZYME5
Bssp2     EC 3.4.218

External Ids:    HGNC: 63671   Entrez Gene: 56532   Ensembl: ENSG000001677557   OMIM: 6026525   UniProtKB: Q928763   

Export aliases for KLK6 gene to outside databases

Previous GC identifers: GC19M052090 GC19M051823 GC19M056137 GC19M056153 GC19M047795


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK6 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate
amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's
disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLK6 Gene: 
KLK6 (kallikrein-related peptidase 6) is a protein-coding gene. Diseases associated with KLK6 include spinal cord injury, and vascular dementia, and among its related super-pathways are Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include protein binding and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
Function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or
Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein
and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades
alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of
Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal
cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a
role in invasion and metastasis

Gene Wiki entry for KLK6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK6 gene promoter:
         AREB6   NF-kappaB2   Nkx2-5   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLK6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3

KLK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051461:  view genomic region     (about GC identifiers)

Start:
51,461,887 bp from pter      End:
51,472,929 bp from pter
Size:
11,043 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876 (See protein sequence)
Recommended Name: Kallikrein-6 precursor  
Size: 244 amino acids; 26856 Da
Subcellular location: Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected
in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and
microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress
Mass spectrometry: Mass=25866; Method=MALDI; Range=22-244; Source=PubMed:11983703;
5 PDB 3D structures from and Proteopedia for KLK6:
1GVL (3D)        1L2E (3D)        1LO6 (3D)        3VFE (3D)        4D8N (3D)    
Secondary accessions: A6NJA1 A8MW09 Q6H301
Alternative splicing: 3 isoforms:  Q92876-1   Q92876-2   Q92876-3   

Explore the universe of human proteins at neXtProt for KLK6: NX_Q92876

Explore proteomics data for KLK6 at MOPED 

Post-translational modifications:

  • UniProtKB: Inactivated by autolytic cleavage after Arg-80
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92876

  • 4/6 DME Specific Peptides for KLK6 (Q92876) (see all 6)
     GDSGGPL  VLTAAHC  SGGPLVC  WVLTAAH 

    KLK6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLK6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001012982.1  NP_001012983.1  NP_002765.1  

    ENSEMBL proteins: 
     ENSP00000366047   ENSP00000309148   ENSP00000469630   ENSP00000470482   ENSP00000471948  
     ENSP00000469702   ENSP00000366049   ENSP00000375684   ENSP00000409241   ENSP00000396012  

    Human Recombinant Protein Products for KLK6: 
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    Novus Biologicals KLK6 Proteins
    Novus Biologicals KLK6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLK6 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11668196
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA11668196
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--

    KLK6 for ontologies           About GeneDecksing



    KLK6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KLK: Kallikreins
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q92876

    ProtoNet protein and cluster: Q92876

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK6_HUMAN, Q92876
    Function: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or
    Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein
    and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades
    alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of
    Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal
    cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a
    role in invasion and metastasis
    Enzyme regulation: Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor,
    benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan
    sulfate, heparan sulfate and heparin
    Biophysicochemical properties: Kinetic parameters: KM=1562 uM for Tosyl-Gly-Pro-Arg-AMC; KM=777 uM for
    Tosyl-Gly-Pro-Lys-AMC; KM=0.410 mM for Phe-Ser-Arg-AMC; KM=0.455 mM for Gly-Gly-Arg-AMC; KM=0.335 mM for
    Asp-Pro-Arg-AMC; KM=0.758 mM for Gln-Gly-Arg-AMC; KM=0.625 mM for Pro-Phe-Arg-AMC; KM=0.271 mM for
    Val-Pro-Arg-AMC; KM=1.72 mM for Val-Leu-Lys-AMC;
    Induction: By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive
    astrocytes

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS12878203
    GO:0005515protein binding IPI12709365
    GO:0008233peptidase activity ----
         
    KLK6 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-let-7f (MIRT004678)

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    SwitchGear 3'UTR luciferase reporter plasmidKLK6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLK6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.40
    Blood Coagulation Cascade0.39
    2MSP-RON Signaling
    MSP-RON Signaling
    3Alpha-synuclein signaling
    Alpha-synuclein signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK6
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    1 BioSystems Pathway for KLK6
        Alpha-synuclein signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for KLK6 (Q928763 ENSP000003091484) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINF2P086973, ENSP000003218534I2D: score=2 STRING: ENSP00000321853
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    CSN1S1P477103, ENSP000002468914I2D: score=1 STRING: ENSP00000246891
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007417central nervous system development NAS12589961
    GO:0009611response to wounding NAS12016211
    GO:0010975regulation of neuron projection development IEA--
    GO:0016540protein autoprocessing NAS12878203

    KLK6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLK6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLK6

    1 HMDB Compound for KLK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    DermatanChondroitin sulfate B (see all 13)24967-94-0--

    1 DrugBank Compound for KLK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423

    3 Novoseek inferred chemical compound relationships for KLK6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 70.1 39 10997858 (2), 11388408 (2), 9003450 (2), 15299321 (2) (see all 25)
    steroid 30.7 2 10675891 (1), 16897430 (1)
    calcium 0 3 15305371 (1), 16800746 (1), 15299321 (1)

    Search CenterWatch for drugs/clinical trials and news about KLK6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLK6 gene (4 alternative transcripts): 
    NM_001012964.1  NM_001012965.1  NM_002774.3  NM_001012966.1  

    Unigene Cluster for KLK6:

    Kallikrein-related peptidase 6
    Hs.79361  [show with all ESTs]
    Unigene Representative Sequence: NM_002774
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376851(uc002pui.3 uc010ycn.2) ENST00000310157(uc010eoj.3 uc002puh.3 uc002pul.3 uc002pum.3)
    ENST00000597379 ENST00000594641 ENST00000599881 ENST00000599690 ENST00000376853
    ENST00000391808(uc002puj.3) ENST00000456750 ENST00000424910

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    Additional mRNA sequence: 

    AF013988.1 AK314897.1 AY279383.1 AY318867.1 AY318868.1 AY318869.1 AY318870.1 AY457039.1 
    BC015525.2 BT006852.1 D78203.1 DQ223012.1 U62801.1 

    7 DOTS entries:

    DT.97854762  DT.100752295  DT.101983443  DT.100752293  DT.91715397  DT.121475439  DT.91639926 

    24/189 AceView cDNA sequences (see all 189):

    AY318869 U54605 BX103658 AA444380 AA477689 BM847505 AI339533 AA293027 
    AI538200 AY318867 CB154539 BC015525 CR608439 AA293231 NM_002774 BM761613 
    AA527323 BG821445 AA293573 AY318868 BM763657 BM761360 BM843863 BM845468 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KLK6 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:        -     -           -                                             
    SP2:        -     -           -           -                                 
    SP3:                          -                                             
    SP4:                          -           -                                 
    SP5:                          -     -                                       


    ECgene alternative splicing isoforms for KLK6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLK6 expression in normal human tissues (normalized intensities)      KLK6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCAATAA
    KLK6 Expression
    About this image


    KLK6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Lymph (Hematopoietic System)
             lymph node   
     
     Eye (Sensory Organs)
             Limbal epithelial stem cells
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Spinal Cord (Nervous System)

    See KLK6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLK6

    SOURCE GeneReport for Unigene cluster: Hs.79361

    UniProtKB/Swiss-Prot: KLK6_HUMAN, Q92876
    Tissue specificity: In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid,
    nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and
    breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in
    glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary
    and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis,
    pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein
    level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions.
    Overexpressed in primary breast tumors but not expressed in metastatic tumors

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLK6 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk61 , 5 kallikrein related-peptidase 61, 5 75(n)1
    68.44(a)1
      7 (28.28 cM)5
    191441  NM_001164696.11  NP_001158168.11 
     438244995 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    36(a)
    34(a)
    1 ↔ many
    possible ortholog
    GL343276.1(1756111-1760844)
    GL343514.1(217681-240007)


    ENSEMBL Gene Tree for KLK6 (if available)
    TreeFam Gene Tree for KLK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLK6 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    18/84 SIMAP similar genes for KLK6 using alignment to 4 protein entries:     KLK6_HUMAN (see all proteins) (see all similar genes):
    KLK4    KLK2    KLK11    KLK8    KLK15    PRSS1
    TRY6    PRSS2    KLK13    TRY8    PRSS3    KLK7
    KLK9    KLK14    KLK1    KLK3    APS    CFD

    KLK6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/372 SNPs in KLK6 are shown (see all 372)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883243361,2
    --51461622(+) AGGGAA/GGAGAA 3 -- ds50010--------
    rs1924815491,2
    --51461662(+) GTGAGC/GCGAGA 3 -- ds50010--------
    rs1845312271,2
    --51461676(+) CGCCAC/TTGCAC 3 -- ds50010--------
    rs1483331021,2
    C--51461759(+) GAGGTA/C/GTAGCA 3 -- ds50010--------
    rs1906768751,2
    --51461913(+) ATTGAG/TTGCAT 3 -- ut310--------
    rs1815262031,2
    --51461914(+) TTGAGC/TGCATG 3 -- ut310--------
    rs2013588461,2
    C--51461971(+) ATCTTC/TCCAAC 3 -- ut310--------
    rs1404920141,2
    C--51462100(+) AGACAA/C/TGTGGC 6 -- ut310--------
    rs1853911801,2
    --51462220(+) GTCCTC/TACTCA 3 -- ut310--------
    rs1895040821,2
    C--51462230(+) ATCACA/GTCCTC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for KLK6 (51461887 - 51472929 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLK6: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602652    OMIM disorders: --

    20/30 diseases for KLK6 (see all 30):    About MalaCards
    spinal cord injury    vascular dementia    transsexualism    breast cyst
    netherton syndrome    testicular cancer    pancreatic ductal adenocarcinoma    ovarian cancer
    alzheimer's disease    papillary carcinoma    parkinson's disease    dementia
    skin disease    meningioma    renal cell carcinoma    prostate cancer
    multiple sclerosis    gastric cancer    colon cancer    colorectal cancer

    2 diseases from the University of Copenhagen DISEASES database for KLK6:
    Ovarian cancer     Netherton syndrome

    KLK6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/16 Novoseek inferred disease relationships for KLK6 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 58.1 29 12633763 (4), 15305183 (4), 16864975 (3), 8898378 (2) (see all 11)
    ovarian carcinoma 44.4 6 11124344 (3), 11054022 (1), 19707197 (1)
    carcinoma papillary 41.3 2 15867230 (2)
    alzheimers disease 30 11 10997858 (2), 18525128 (2), 18620574 (1), 12589961 (1) (see all 7)
    testicular cancer 29.6 1 15911097 (1)
    prostate cancer 27.2 3 12218299 (1), 14696124 (1), 12142373 (1)
    cancer 22.7 6 10675891 (1), 12439719 (1), 14696124 (1), 18627290 (1) (see all 5)
    senile plaques 22.5 1 10997858 (1)
    parkinson disease 21.9 4 10997858 (2), 18358605 (1), 17965832 (1)
    tumors 20.9 26 11054022 (4), 12633763 (3), 16864975 (2), 14633706 (1) (see all 11)

    Genetic Association Database (GAD): KLK6
    Human Genome Epidemiology (HuGE) Navigator: KLK6 (24 documents)

    Export disorders for KLK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLK6 gene, integrated from 9 sources (see all 123):
    (articles sorted by number of sources associating them with KLK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. (PubMed id 9003450)1, 2, 3, 9 Yamashiro K.... Yamaguchi N. (1997)
    2. Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease. (PubMed id 10610719)1, 2, 9 Yousef G.M.... Diamandis E.P. (1999)
    3. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. (PubMed id 11668196)1, 2, 9 Petraki C.D.... Diamandis E.P. (2001)
    4. Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells. (PubMed id 15557757)1, 2, 9 Ghosh M.C....Diamandis E.P. (2004)
    5. A novel protease homolog differentially expressed in breast and ovarian cancer. (PubMed id 8898378)1, 2, 9 Anisowicz A.... Sager R. (1996)
    6. Cloning and characterization of novel isoforms of the human kallikrein 6 gene. (PubMed id 15207701)1, 2, 9 Pampalakis G.... Sotiropoulou G. (2004)
    7. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. (PubMed id 12928483)1, 2, 9 Iwata A....Nukina N. (2003)
    8. Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (2010)
    9. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    10. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5653 HGNC: 6367 AceView: KLK6 Ensembl:ENSG00000167755 euGenes: HUgn5653
    ECgene: KLK6 H-InvDB: KLK6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLK6 gene:
    Search GeneIP for patents involving KLK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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