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Aliases for KLK6 Gene

Aliases for KLK6 Gene

  • Kallikrein Related Peptidase 6 2 3 5
  • Serine Protease 18 3 4
  • Serine Protease 9 3 4
  • Protease M 3 4
  • Neurosin 3 4
  • PRSS18 3 4
  • PRSS9 3 4
  • ZYME 3 4
  • SP59 3 4
  • Kallikrein 6 (Neurosin, Zyme) 2
  • Protease, Serine, 18 2
  • Kallikrein 6 3
  • Kallikrein-6 3
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • Bssp 3
  • Klk7 3
  • HK6 3

External Ids for KLK6 Gene

Previous HGNC Symbols for KLK6 Gene

  • PRSS9
  • PRSS18

Previous GeneCards Identifiers for KLK6 Gene

  • GC19M052090
  • GC19M051823
  • GC19M056137
  • GC19M056153
  • GC19M051461
  • GC19M047795

Summaries for KLK6 Gene

Entrez Gene Summary for KLK6 Gene

  • This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for KLK6 Gene

KLK6 (Kallikrein Related Peptidase 6) is a Protein Coding gene. Diseases associated with KLK6 include Synucleinopathy and Ovarian Cancer. Among its related pathways are Collagen chain trimerization and Alpha-synuclein signaling. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is KLK13.

UniProtKB/Swiss-Prot for KLK6 Gene

  • Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Gene Wiki entry for KLK6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK6 Gene

Genomics for KLK6 Gene

Regulatory Elements for KLK6 Gene

Enhancers for KLK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051018 1.2 Ensembl ENCODE 11.1 -49.8 -49760 2.4 TCF12 GLIS2 ZNF302 EGR1 ZNF366 ZNF416 ETV6 EGR2 SMARCA5 SP3 KLK10 ZNF577 ZNF175 ZNF649 KLK13 KLK6 ZNF350 KLK14 SNORD88C C19orf48
GH19G051016 1.2 Ensembl ENCODE 11.1 -47.7 -47704 1.5 PKNOX1 ATF1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 SP3 REST ZNF175 ZNF615 KLK10 ZNF577 LRRC4B SPACA6 KLK13 KLK6 ZNF649 KLK14
GH19G050968 1 ENCODE 12.3 +0.6 577 2.0 ATF1 ARNT SIN3A E2F7 ZNF48 ZNF766 ELK1 CBX5 FOS CAVIN1 KLK6 KLK7 KLK5 ENSG00000269495 ZNF473 ENSG00000267879
GH19G050929 0.8 ENCODE 11.7 +39.7 39654 0.2 CTCF KLF1 RB1 ARNT TEAD4 ZNF2 RAD21 GLIS2 PATZ1 ZNF143 KLK6 KLK2 SNORD88C C19orf48 LINC01869 CTU1 LOC390956 KLK4
GH19G050931 0.7 ENCODE 11.7 +36.9 36850 2.9 CTCF ESRRA BACH1 RAD21 ZNF316 ZNF366 FOS NFE2 MAFK NFE2L2 KLK4 KLK6 KLK2 KLK15 KLK1 LINC01869 C19orf48 SNORD88C KLK14 CTU1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK6 Gene

Chromosome:
19
Start:
50,958,631 bp from pter
End:
50,969,673 bp from pter
Size:
11,043 bases
Orientation:
Minus strand

Genomic View for KLK6 Gene

Genes around KLK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK6 Gene

Proteins for KLK6 Gene

  • Protein details for KLK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92876-KLK6_HUMAN
    Recommended name:
    Kallikrein-6
    Protein Accession:
    Q92876
    Secondary Accessions:
    • A6NJA1
    • A8MW09
    • Q6H301

    Protein attributes for KLK6 Gene

    Size:
    244 amino acids
    Molecular mass:
    26856 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLK6 Gene

    Alternative splice isoforms for KLK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK6 Gene

Selected DME Specific Peptides for KLK6 Gene

Q92876:
  • VLTAAHC
  • GDSGGPL
  • SGGPLVC
  • DSCQGDSGG
  • CQGDSGGP
  • WVLTAAH

Post-translational modifications for KLK6 Gene

Antibody Products

  • R&D Systems Antibodies for KLK6 (Kallikrein 6/Neurosin)
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLK6

Assay Products

Domains & Families for KLK6 Gene

Gene Families for KLK6 Gene

Suggested Antigen Peptide Sequences for KLK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92876

UniProtKB/Swiss-Prot:

KLK6_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK6: view

Function for KLK6 Gene

Molecular function for KLK6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1562 uM for Tosyl-Gly-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=777 uM for Tosyl-Gly-Pro-Lys-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.410 mM for Phe-Ser-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.455 mM for Gly-Gly-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.335 mM for Asp-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.758 mM for Gln-Gly-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.625 mM for Pro-Phe-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.271 mM for Val-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=1.72 mM for Val-Leu-Lys-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.
UniProtKB/Swiss-Prot Function:
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
UniProtKB/Swiss-Prot Induction:
By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive astrocytes.

Enzyme Numbers (IUBMB) for KLK6 Gene

Gene Ontology (GO) - Molecular Function for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 12878203
GO:0005515 protein binding IPI 12709365
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK6: view
genes like me logo Genes that share phenotypes with KLK6: view

Animal Models for KLK6 Gene

MGI Knock Outs for KLK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK6

miRNA for KLK6 Gene

miRTarBase miRNAs that target KLK6

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLK6 Gene

Localization for KLK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK6 Gene

Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK6 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 11668196
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IEA 11668196
genes like me logo Genes that share ontologies with KLK6: view

Pathways & Interactions for KLK6 Gene

genes like me logo Genes that share pathways with KLK6: view

Pathways by source for KLK6 Gene

1 BioSystems pathway for KLK6 Gene

Gene Ontology (GO) - Biological Process for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007417 central nervous system development NAS 12589961
GO:0009611 response to wounding NAS 12016211
GO:0010975 regulation of neuron projection development IEA --
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with KLK6: view

No data available for SIGNOR curated interactions for KLK6 Gene

Drugs & Compounds for KLK6 Gene

(3) Drugs for KLK6 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
benzamidine Experimental Pharma Target 0

(2) Additional Compounds for KLK6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
genes like me logo Genes that share compounds with KLK6: view

Transcripts for KLK6 Gene

Unigene Clusters for KLK6 Gene

Kallikrein-related peptidase 6:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - -

Relevant External Links for KLK6 Gene

GeneLoc Exon Structure for
KLK6
ECgene alternative splicing isoforms for
KLK6

Expression for KLK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.5), Brain - Substantia nigra (x8.4), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for KLK6 Gene

This gene is overexpressed in Cerebrospinal fluid (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK6 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLK6 Gene:

KLK6

SOURCE GeneReport for Unigene cluster for KLK6 Gene:

Hs.79361

mRNA Expression by UniProt/SwissProt for KLK6 Gene:

Q92876-KLK6_HUMAN
Tissue specificity: In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.

Evidence on tissue expression from TISSUES for KLK6 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with KLK6: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK6 Gene

Orthologs for KLK6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia KLK6 34 35
  • 87.84 (n)
cow
(Bos Taurus)
Mammalia KLK6 34 35
  • 83.61 (n)
rat
(Rattus norvegicus)
Mammalia Klk6 34
  • 75.27 (n)
mouse
(Mus musculus)
Mammalia Klk6 34 16 35
  • 75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLK6 35
  • 49 (a)
OneToOne
Species where no ortholog for KLK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK6 Gene

ENSEMBL:
Gene Tree for KLK6 (if available)
TreeFam:
Gene Tree for KLK6 (if available)

Paralogs for KLK6 Gene

genes like me logo Genes that share paralogs with KLK6: view

Variants for KLK6 Gene

Sequence variations from dbSNP and Humsavar for KLK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000013970 -- 50,970,025(+) CCCTT(C/T)CTCCC intron-variant, upstream-variant-2KB
rs1000128279 -- 50,969,743(+) GGAGG(A/G)CGGTT intron-variant, upstream-variant-2KB
rs1000170864 -- 50,966,301(+) TCCCT(C/T)CTGTT intron-variant
rs1000240047 -- 50,965,053(+) TTCCT(A/T)CATAA intron-variant
rs1000361952 -- 50,959,748(+) GAGGA(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK6 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for KLK6 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK6 Gene

Human Gene Mutation Database (HGMD)
KLK6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK6 Gene

Disorders for KLK6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLK6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
synucleinopathy
  • alpha synucleinopathies
ovarian cancer
  • malignant ovarian tumor
demyelinating disease
  • demyelinating disorder
- elite association - COSMIC cancer census association via MalaCards
Search KLK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK6

Genetic Association Database (GAD)
KLK6
Human Genome Epidemiology (HuGE) Navigator
KLK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK6
genes like me logo Genes that share disorders with KLK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK6 Gene

Publications for KLK6 Gene

  1. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. (PMID: 9003450) Yamashiro K. … Yamaguchi N. (Biochim. Biophys. Acta 1997) 2 3 4 22 64
  2. Cloning and characterization of novel isoforms of the human kallikrein 6 gene. (PMID: 15207701) Pampalakis G. … Sotiropoulou G. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  3. Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells. (PMID: 15557757) Ghosh M.C. … Diamandis E.P. (Tumor Biol. 2004) 3 4 22 64
  4. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. (PMID: 12928483) Iwata A. … Nukina N. (Hum. Mol. Genet. 2003) 3 4 22 64
  5. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. (PMID: 11668196) Petraki C.D. … Diamandis E.P. (J. Histochem. Cytochem. 2001) 3 4 22 64

Products for KLK6 Gene

Sources for KLK6 Gene

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