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Aliases for KLK6 Gene

Aliases for KLK6 Gene

  • Kallikrein Related Peptidase 6 2 3 5
  • Serine Protease 18 3 4
  • Serine Protease 9 3 4
  • Protease M 3 4
  • Neurosin 3 4
  • PRSS18 3 4
  • PRSS9 3 4
  • ZYME 3 4
  • SP59 3 4
  • Kallikrein 6 (Neurosin, Zyme) 2
  • Protease, Serine, 18 2
  • Kallikrein 6 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Bssp 3
  • Klk7 3
  • HK6 3

External Ids for KLK6 Gene

Previous HGNC Symbols for KLK6 Gene

  • PRSS9
  • PRSS18

Previous GeneCards Identifiers for KLK6 Gene

  • GC19M052090
  • GC19M051823
  • GC19M056137
  • GC19M056153
  • GC19M051461
  • GC19M047795

Summaries for KLK6 Gene

Entrez Gene Summary for KLK6 Gene

  • This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for KLK6 Gene

KLK6 (Kallikrein Related Peptidase 6) is a Protein Coding gene. Diseases associated with KLK6 include Ovarian Cancer and Synucleinopathy. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK6 Gene

  • Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Gene Wiki entry for KLK6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK6 Gene

Genomics for KLK6 Gene

Regulatory Elements for KLK6 Gene

Enhancers for KLK6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK6 Gene

Chromosome:
19
Start:
50,958,631 bp from pter
End:
50,969,673 bp from pter
Size:
11,043 bases
Orientation:
Minus strand

Genomic View for KLK6 Gene

Genes around KLK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK6 Gene

Proteins for KLK6 Gene

  • Protein details for KLK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92876-KLK6_HUMAN
    Recommended name:
    Kallikrein-6
    Protein Accession:
    Q92876
    Secondary Accessions:
    • A6NJA1
    • A8MW09
    • Q6H301

    Protein attributes for KLK6 Gene

    Size:
    244 amino acids
    Molecular mass:
    26856 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLK6 Gene

    Alternative splice isoforms for KLK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK6 Gene

Proteomics data for KLK6 Gene at MOPED

Selected DME Specific Peptides for KLK6 Gene

Post-translational modifications for KLK6 Gene

Antibody Products

  • R&D Systems Antibodies for KLK6 (Kallikrein 6/Neurosin)

Assay Products

  • Enzo Life Sciences assays for KLK6
  • Cloud-Clone Corp Assay Kits for KLK6

Domains & Families for KLK6 Gene

Gene Families for KLK6 Gene

Suggested Antigen Peptide Sequences for KLK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92876

UniProtKB/Swiss-Prot:

KLK6_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK6: view

Function for KLK6 Gene

Molecular function for KLK6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1562 uM for Tosyl-Gly-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=777 uM for Tosyl-Gly-Pro-Lys-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.410 mM for Phe-Ser-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.455 mM for Gly-Gly-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.335 mM for Asp-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.758 mM for Gln-Gly-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.625 mM for Pro-Phe-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=0.271 mM for Val-Pro-Arg-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203}; KM=1.72 mM for Val-Leu-Lys-AMC {ECO:0000269 PubMed:11983703, ECO:0000269 PubMed:12878203};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.
UniProtKB/Swiss-Prot Function:
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
UniProtKB/Swiss-Prot Induction:
By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive astrocytes.

Enzyme Numbers (IUBMB) for KLK6 Gene

genes like me logo Genes that share phenotypes with KLK6: view

Animal Models for KLK6 Gene

MGI Knock Outs for KLK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK6

miRNA for KLK6 Gene

miRTarBase miRNAs that target KLK6

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLK6 Gene

Localization for KLK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK6 Gene

Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK6 Gene COMPARTMENTS Subcellular localization image for KLK6 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 11668196
GO:0005783 endoplasmic reticulum IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with KLK6: view

Pathways & Interactions for KLK6 Gene

genes like me logo Genes that share pathways with KLK6: view

Pathways by source for KLK6 Gene

1 BioSystems pathway for KLK6 Gene

Gene Ontology (GO) - Biological Process for KLK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0009611 response to wounding NAS 12016211
GO:0010975 regulation of neuron projection development IEA --
GO:0016485 protein processing IBA --
GO:0042445 hormone metabolic process NAS 11668196
genes like me logo Genes that share ontologies with KLK6: view

No data available for SIGNOR curated interactions for KLK6 Gene

Drugs & Compounds for KLK6 Gene

(3) Drugs for KLK6 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
benzamidine Experimental Pharma Target 0

(2) Additional Compounds for KLK6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
genes like me logo Genes that share compounds with KLK6: view

Transcripts for KLK6 Gene

Unigene Clusters for KLK6 Gene

Kallikrein-related peptidase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - -

Relevant External Links for KLK6 Gene

GeneLoc Exon Structure for
KLK6
ECgene alternative splicing isoforms for
KLK6

Expression for KLK6 Gene

mRNA expression in normal human tissues for KLK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.5), Brain - Substantia nigra (x8.4), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for KLK6 Gene

This gene is overexpressed in Cerebrospinal fluid (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK6 Gene



SOURCE GeneReport for Unigene cluster for KLK6 Gene Hs.79361

mRNA Expression by UniProt/SwissProt for KLK6 Gene

Q92876-KLK6_HUMAN
Tissue specificity: In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
genes like me logo Genes that share expression patterns with KLK6: view

Primer Products

No data available for Protein tissue co-expression partners for KLK6 Gene

Orthologs for KLK6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK6 35
  • 83.61 (n)
  • 80.33 (a)
KLK6 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK6 35
  • 87.84 (n)
  • 85.66 (a)
KLK6 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk6 35
  • 75 (n)
  • 68.44 (a)
Klk6 16
Klk6 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk6 35
  • 75.27 (n)
  • 66.8 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia KLK6 36
  • 49 (a)
OneToOne
Species with no ortholog for KLK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK6 Gene

ENSEMBL:
Gene Tree for KLK6 (if available)
TreeFam:
Gene Tree for KLK6 (if available)

Paralogs for KLK6 Gene

genes like me logo Genes that share paralogs with KLK6: view

Variants for KLK6 Gene

Sequence variations from dbSNP and Humsavar for KLK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_061776 -
rs71185782 -- 50,959,409(-) TCTGT(-/CACACACA)CACAC intron-variant
rs71333920 -- 50,959,363(+) GAGAC(-/CT/TG/TGTGTGTG)TGTGT intron-variant
rs140188353 -- 50,959,281(+) CGGAG(G/T)TGGTC reference, missense
rs140492014 -- 50,958,844(+) AGACA(A/C/T)GTGGC utr-variant-3-prime

Variation tolerance for KLK6 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KLK6 Gene

Disorders for KLK6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KLK6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
synucleinopathy
  • alpha synucleinopathies
demyelinating disease
  • demyelinating disorder
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
parkinson disease, late-onset
  • parkinson disease
- elite association - COSMIC cancer census association via MalaCards
Search KLK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK6

Genetic Association Database (GAD)
KLK6
Human Genome Epidemiology (HuGE) Navigator
KLK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK6
genes like me logo Genes that share disorders with KLK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK6 Gene

Publications for KLK6 Gene

  1. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. (PMID: 9003450) Yamashiro K. … Yamaguchi N. (Biochim. Biophys. Acta 1997) 2 3 4 23 67
  2. KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma. (PMID: 19707197) White N.M. … DorAc J.J. (Br. J. Cancer 2009) 3 23
  3. Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. (PMID: 18627290) Henkhaus R.S. … Ignatenko N.A. (Biol. Chem. 2008) 3 23
  4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 3
  5. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A. … Yousef G.M. (Biol. Chem. 2006) 2 3

Products for KLK6 Gene

Sources for KLK6 Gene

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