Aliases for KLK6 Gene
External Ids for KLK6 Gene
Previous HGNC Symbols for KLK6 Gene
Previous GeneCards Identifiers for KLK6 Gene
This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
GeneCards Summary for KLK6 Gene
KLK6 (Kallikrein Related Peptidase 6) is a Protein Coding gene. Diseases associated with KLK6 include synucleinopathy and demyelinating disease. Among its related pathways are MSP-RON Signaling and Alpha-synuclein signaling. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is KLK12.
UniProtKB/Swiss-Prot for KLK6 Gene
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.