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Aliases for KLK5 Gene

Aliases for KLK5 Gene

  • Kallikrein-Related Peptidase 5 2 3
  • SCTE 3 4 6
  • Stratum Corneum Tryptic Enzyme 3 4
  • Kallikrein-Like Protein 2 3 4
  • Kallikrein 5 2 3
  • KLK-L2 3 4
  • KLKL2 3 6
  • Kallikrein-5 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for KLK5 Gene

Summaries for KLK5 Gene

Entrez Gene Summary for KLK5 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK5 Gene

KLK5 (Kallikrein-Related Peptidase 5) is a Protein Coding gene. Diseases associated with KLK5 include prostate cancer. Among its related pathways are Collagen biosynthesis and modifying enzymes and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK5 Gene

  • May be involved in desquamation

Gene Wiki entry for KLK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK5 Gene

Genomics for KLK5 Gene

Genomic Location for KLK5 Gene

Start:
50,943,303 bp from pter
End:
50,953,093 bp from pter
Size:
9,791 bases
Orientation:
Minus strand

Genomic View for KLK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK5 Gene

Regulatory Elements for KLK5 Gene

Proteins for KLK5 Gene

  • Protein details for KLK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y337-KLK5_HUMAN
    Recommended name:
    Kallikrein-5
    Protein Accession:
    Q9Y337
    Secondary Accessions:
    • Q53ZR3
    • Q9HBG8

    Protein attributes for KLK5 Gene

    Size:
    293 amino acids
    Molecular mass:
    32019 Da
    Quaternary structure:
    • Interacts with SPINK9.

    Three dimensional structures from OCA and Proteopedia for KLK5 Gene

neXtProt entry for KLK5 Gene

Proteomics data for KLK5 Gene at MOPED

Selected DME Specific Peptides for KLK5 Gene

Post-translational modifications for KLK5 Gene

  • Glycosylation at Asn69, Asn173, Asn208, and Asn252

Other Protein References for KLK5 Gene

Domains for KLK5 Gene

Gene Families for KLK5 Gene

HGNC:
  • KLK :Kallikreins

Suggested Antigen Peptide Sequences for KLK5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y337

UniProtKB/Swiss-Prot:

KLK5_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • Q9Y337
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.:
    • Q9Y337
genes like me logo Genes that share domains with KLK5: view

Function for KLK5 Gene

Molecular function for KLK5 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by Zn2+.
UniProtKB/Swiss-Prot Function: May be involved in desquamation

Enzyme Numbers (IUBMB) for KLK5 Gene

Gene Ontology (GO) - Molecular Function for KLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 11054574
GO:0005515 protein binding IPI 19194479
GO:0008233 peptidase activity TAS 10608802
GO:0008236 serine-type peptidase activity TAS 10514489
genes like me logo Genes that share ontologies with KLK5: view
genes like me logo Genes that share phenotypes with KLK5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLK5 Gene

Localization for KLK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK5 Gene COMPARTMENTS Subcellular localization image for KLK5 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for KLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 10608802
GO:0097209 epidermal lamellar body IDA 15675955
genes like me logo Genes that share ontologies with KLK5: view

Pathways for KLK5 Gene

genes like me logo Genes that share pathways with KLK5: view

Pathways by source for KLK5 Gene

Gene Ontology (GO) - Biological Process for KLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008544 epidermis development TAS 10514489
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IDA 16885167
genes like me logo Genes that share ontologies with KLK5: view

Compounds for KLK5 Gene

(3) Novoseek inferred chemical compound relationships for KLK5 Gene

Compound -log(P) Hits PubMed IDs
serine 66.1 9
progestins 59.4 2
steroid 1.93 1
genes like me logo Genes that share compounds with KLK5: view

Transcripts for KLK5 Gene

Unigene Clusters for KLK5 Gene

Kallikrein-related peptidase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - -
SP4: -
SP5:

Relevant External Links for KLK5 Gene

GeneLoc Exon Structure for
KLK5
ECgene alternative splicing isoforms for
KLK5

Expression for KLK5 Gene

mRNA expression in normal human tissues for KLK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (21.5) and Skin - Not Sun Exposed (Suprapubic) (17.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLK5 Gene

SOURCE GeneReport for Unigene cluster for KLK5 Gene Hs.50915

mRNA Expression by UniProt/SwissProt for KLK5 Gene

Q9Y337-KLK5_HUMAN
Tissue specificity: Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.
genes like me logo Genes that share expressions with KLK5: view

Orthologs for KLK5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK5 35
  • 99.09 (n)
  • 99.32 (a)
KLK5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLK5 35
  • 80.09 (n)
  • 74.74 (a)
KLK5 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK5 35
  • 81.46 (n)
  • 77.82 (a)
KLK5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk5 35
  • 75.49 (n)
  • 70.45 (a)
Klk5 16
Klk5 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLK5 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102546758 35
  • 73.44 (n)
  • 69.29 (a)
Species with no ortholog for KLK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK5 Gene

ENSEMBL:
Gene Tree for KLK5 (if available)
TreeFam:
Gene Tree for KLK5 (if available)

Paralogs for KLK5 Gene

Pseudogenes.org Pseudogenes for KLK5 Gene

genes like me logo Genes that share paralogs with KLK5: view

Variants for KLK5 Gene

Sequence variations from dbSNP and Humsavar for KLK5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs183854 - 50,948,994(-) CTAAC(A/G)ACCTC missense, reference
rs268900 -- 50,949,714(-) GAGGG(C/T)TGGTG intron-variant
rs268901 -- 50,949,544(-) GGAGC(A/G)TATAT intron-variant
rs268902 -- 50,948,431(-) aaaca(A/G)gtaaa intron-variant
rs268903 -- 50,948,412(-) ggcgc(A/G)gtggc intron-variant

Relevant External Links for KLK5 Gene

HapMap Linkage Disequilibrium report
KLK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLK5 Gene

Disorders for KLK5 Gene

(1) MalaCards Diseases for KLK5 Gene

Search for KLK5 Gene in MalaCards »

(4) University of Copenhagen DISEASES for KLK5 Gene

(6) Novoseek inferred disease relationships for KLK5 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 52.6 6
ovarian carcinoma 43.3 1
breast cancer 12.5 4
prostate cancer 2.52 4
tumors 0 4

Relevant External Links for KLK5

Genetic Association Database (GAD)
KLK5
Human Genome Epidemiology (HuGE) Navigator
KLK5
genes like me logo Genes that share disorders with KLK5: view

No data available for UniProtKB/Swiss-Prot for KLK5 Gene

Publications for KLK5 Gene

  1. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. (PMID: 10514489) Brattsand M. … Egelrud T. (J. Biol. Chem. 1999) 2 3 4 23
  2. The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation. (PMID: 10608802) Yousef G.M. … Diamandis E.P. (J. Biol. Chem. 1999) 2 3 23
  3. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. (PMID: 17012259) Yamasaki K. … Gallo R.L. (FASEB J. 2006) 2 3 23
  4. SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PMID: 19194479) Brattsand M. … Egelrud T. (J. Invest. Dermatol. 2009) 3 4 23
  5. KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer. (PMID: 15766562) Planque C. … Courty Y. (Biochem. Biophys. Res. Commun. 2005) 3 23

Products for KLK5 Gene

Sources for KLK5 Gene

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