Aliases for KLK5 Gene
External Ids for KLK5 Gene
Previous GeneCards Identifiers for KLK5 Gene
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLK5 Gene
KLK5 (Kallikrein Related Peptidase 5) is a Protein Coding gene. Diseases associated with KLK5 include Ovarian Cancer, Somatic. Among its related pathways are Keratinization and Collagen chain trimerization. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK4.
UniProtKB/Swiss-Prot for KLK5 Gene
May be involved in desquamation.