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Aliases for KLK5 Gene

Aliases for KLK5 Gene

  • Kallikrein Related Peptidase 5 2 3 5
  • Stratum Corneum Tryptic Enzyme 3 4
  • Kallikrein-Like Protein 2 3 4
  • Kallikrein 5 2 3
  • KLK-L2 3 4
  • SCTE 3 4
  • Kallikrein-Related Peptidase 5 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • KLKL2 3

External Ids for KLK5 Gene

Previous GeneCards Identifiers for KLK5 Gene

  • GC19M052075
  • GC19M051807
  • GC19M056122
  • GC19M056138
  • GC19M051446
  • GC19M047780

Summaries for KLK5 Gene

Entrez Gene Summary for KLK5 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK5 Gene

KLK5 (Kallikrein Related Peptidase 5) is a Protein Coding gene. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK5 Gene

  • May be involved in desquamation.

Gene Wiki entry for KLK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK5 Gene

Genomics for KLK5 Gene

Regulatory Elements for KLK5 Gene

Enhancers for KLK5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLK5 on UCSC Golden Path with GeneCards custom track

Promoters for KLK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK5 Gene

Chromosome:
19
Start:
50,943,299 bp from pter
End:
50,953,093 bp from pter
Size:
9,795 bases
Orientation:
Minus strand

Genomic View for KLK5 Gene

Genes around KLK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK5 Gene

Proteins for KLK5 Gene

  • Protein details for KLK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y337-KLK5_HUMAN
    Recommended name:
    Kallikrein-5
    Protein Accession:
    Q9Y337
    Secondary Accessions:
    • Q53ZR3
    • Q9HBG8

    Protein attributes for KLK5 Gene

    Size:
    293 amino acids
    Molecular mass:
    32019 Da
    Quaternary structure:
    • Interacts with SPINK9.

    Three dimensional structures from OCA and Proteopedia for KLK5 Gene

neXtProt entry for KLK5 Gene

Proteomics data for KLK5 Gene at MOPED

Selected DME Specific Peptides for KLK5 Gene

Post-translational modifications for KLK5 Gene

  • Glycosylation at Asn 69, Asn 173, Asn 208, and Asn 252
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK5 Gene

Antibody Products

Domains & Families for KLK5 Gene

Gene Families for KLK5 Gene

Suggested Antigen Peptide Sequences for KLK5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y337

UniProtKB/Swiss-Prot:

KLK5_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK5: view

Function for KLK5 Gene

Molecular function for KLK5 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Zn2+.
UniProtKB/Swiss-Prot Function:
May be involved in desquamation.

Enzyme Numbers (IUBMB) for KLK5 Gene

genes like me logo Genes that share phenotypes with KLK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK5

miRNA for KLK5 Gene

miRTarBase miRNAs that target KLK5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK5 Gene

Localization for KLK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK5 Gene COMPARTMENTS Subcellular localization image for KLK5 gene
Compartment Confidence
extracellular 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for KLK5 Gene

Pathways & Interactions for KLK5 Gene

genes like me logo Genes that share pathways with KLK5: view

Pathways by source for KLK5 Gene

Gene Ontology (GO) - Biological Process for KLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IDA 16885167
genes like me logo Genes that share ontologies with KLK5: view

No data available for SIGNOR curated interactions for KLK5 Gene

Drugs & Compounds for KLK5 Gene

(2) Drugs for KLK5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK5: view

Transcripts for KLK5 Gene

Unigene Clusters for KLK5 Gene

Kallikrein-related peptidase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - -
SP4: -
SP5:

Relevant External Links for KLK5 Gene

GeneLoc Exon Structure for
KLK5
ECgene alternative splicing isoforms for
KLK5

Expression for KLK5 Gene

mRNA expression in normal human tissues for KLK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.5) and Skin - Not Sun Exposed (Suprapubic) (x17.7).

Protein differential expression in normal tissues from HIPED for KLK5 Gene

This gene is overexpressed in Testis (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK5 Gene



SOURCE GeneReport for Unigene cluster for KLK5 Gene Hs.50915

mRNA Expression by UniProt/SwissProt for KLK5 Gene

Q9Y337-KLK5_HUMAN
Tissue specificity: Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.
genes like me logo Genes that share expression patterns with KLK5: view

Protein tissue co-expression partners for KLK5 Gene

Primer Products

Orthologs for KLK5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK5 35
  • 80.09 (n)
  • 74.74 (a)
KLK5 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK5 35
  • 81.46 (n)
  • 77.82 (a)
KLK5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk5 35
  • 75.49 (n)
  • 70.45 (a)
Klk5 16
Klk5 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLK5 35
  • 99.09 (n)
  • 99.32 (a)
KLK5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102546758 35
  • 73.44 (n)
  • 69.29 (a)
oppossum
(Monodelphis domestica)
Mammalia KLK5 36
  • 56 (a)
OneToOne
Species with no ortholog for KLK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK5 Gene

ENSEMBL:
Gene Tree for KLK5 (if available)
TreeFam:
Gene Tree for KLK5 (if available)

Paralogs for KLK5 Gene

Pseudogenes.org Pseudogenes for KLK5 Gene

genes like me logo Genes that share paralogs with KLK5: view

Variants for KLK5 Gene

Sequence variations from dbSNP and Humsavar for KLK5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2232532 - 50,950,027(-) GGGCC(A/C/G)GGGAA reference, missense
rs183854 - 50,948,994(-) CTAAC(A/G)ACCTC reference, missense
rs7259003 -- 50,950,840(+) TGAGC(C/T)GAGAT intron-variant
rs12979210 -- 50,944,926(+) CATTT(C/T)TTTCC intron-variant
rs12979237 -- 50,946,660(+) gttca(C/G)gccat intron-variant

Variation tolerance for KLK5 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KLK5 Gene

Disorders for KLK5 Gene

Relevant External Links for KLK5

Genetic Association Database (GAD)
KLK5
Human Genome Epidemiology (HuGE) Navigator
KLK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK5

No disorders were found for KLK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK5 Gene

Publications for KLK5 Gene

  1. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. (PMID: 10514489) Brattsand M. … Egelrud T. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. (PMID: 17012259) Yamasaki K. … Gallo R.L. (FASEB J. 2006) 2 3 23
  3. The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation. (PMID: 10608802) Yousef G.M. … Diamandis E.P. (J. Biol. Chem. 1999) 2 3 23
  4. Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid. (PMID: 20090765) Morizane S. … Gallo R.L. (J. Invest. Dermatol. 2010) 3 23
  5. Dichotomous effect of ultraviolet B on the expression of corneodesmosomal enzymes in human epidermal keratinocytes. (PMID: 19118981) Nin M. … Kishimoto S. (J. Dermatol. Sci. 2009) 3 23

Products for KLK5 Gene

Sources for KLK5 Gene

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