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KLK5 Gene

protein-coding   GIFtS: 59
GCID: GC19M051446

Kallikrein-Related Peptidase 5

(Previous name: kallikrein 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 51 2     KLKL22 5
SCTE2 3 5     kallikrein-52
Kallikrein 51 2     EC 3.4.21.-3
Kallikrein-Like Protein 22 3     EC 3.4.218
Stratum Corneum Tryptic Enzyme2 3     EC 3.4.21.48
KLK-L22 3     

External Ids:    HGNC: 63661   Entrez Gene: 258182   Ensembl: ENSG000001677547   OMIM: 6056435   UniProtKB: Q9Y3373   

Export aliases for KLK5 gene to outside databases

Previous GC identifers: GC19M052075 GC19M051807 GC19M056122 GC19M056138 GC19M047780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK5 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved
in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same
protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLK5 Gene:
KLK5 (kallikrein-related peptidase 5) is a protein-coding gene. Diseases associated with KLK5 include rosacea, and netherton syndrome. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337
Function: May be involved in desquamation

Gene Wiki entry for KLK5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK5 gene promoter:
         AML1a   Nkx2-5   NF-kappaB   AREB6   NF-kappaB2   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK5 promoter sequence
   Search Chromatin IP Primers for KLK5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051446:  view genomic region     (about GC identifiers)

Start:
51,446,559 bp from pter      End:
51,456,349 bp from pter
Size:
9,791 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337 (See protein sequence)
Recommended Name: Kallikrein-5 precursor  
Size: 293 amino acids; 32019 Da
Subunit: Interacts with SPINK9
2 PDB 3D structures from and Proteopedia for KLK5:
2PSX (3D)        2PSY (3D)    
Secondary accessions: Q53ZR3 Q9HBG8

Explore the universe of human proteins at neXtProt for KLK5: NX_Q9Y337

Explore proteomics data for KLK5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn69, Asn173, Asn208, Asn252
  • 3 DME Specific Peptides for KLK5 (Q9Y337)
     CQGDSGGP  DSCQGDSGG  DSGGPVVCNG 


    See KLK5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070959.1  NP_001070960.1  NP_036559.1  

    ENSEMBL proteins: 
     ENSP00000375685   ENSP00000337733   ENSP00000471966   ENSP00000469439  

    KLK5 Human Recombinant Protein Products:

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    KLK5 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9Y337

    ProtoNet protein and cluster: Q9Y337

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK5_HUMAN, Q9Y337
    Function: May be involved in desquamation
    Enzyme regulation: Inhibited by Zn2+

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS11054574
    GO:0005515protein binding IPI19194479
    GO:0008233peptidase activity TAS10608802
    GO:0008236serine-type peptidase activity TAS10514489
         
    KLK5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KLK5:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK5
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate KLK5:
    hsa-miR-185 hsa-miR-4306
    SwitchGear 3'UTR luciferase reporter plasmidKLK5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLK5

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK5_HUMAN, Q9Y337: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS10608802
    GO:0097209epidermal lamellar body IDA15675955

    KLK5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK5
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK5
    Interactions:

        GeneGlobe Interaction Network for KLK5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KLK5 (Q9Y3373 ENSP000003377334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DSG1Q024133, ENSP000002571924I2D: score=1 STRING: ENSP00000257192
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    CAMPP499133I2D: score=1 
    SHBGENSP000003698164STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008544epidermis development TAS10514489
    GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway IDA16885167

    KLK5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for KLK5
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK5

    3 Novoseek inferred chemical compound relationships for KLK5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 66.1 15 12890555 (1), 15004490 (1), 15140227 (1), 20090765 (1) (see all 9)
    progestins 59.4 2 10608802 (1), 15004490 (1)
    steroid 1.93 1 11948967 (1)



    KLK5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLK5 gene (3 alternative transcripts): 
    NM_001077491.1  NM_001077492.1  NM_012427.4  

    Unigene Cluster for KLK5:

    Kallikrein-related peptidase 5
    Hs.50915  [show with all ESTs]
    Unigene Representative Sequence: AY359010
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391809(uc002pue.3 uc002puf.3) ENST00000336334(uc002pug.3)
    ENST00000593428 ENST00000595585 ENST00000594846
    miRNA
    Products:
         
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    2 qRT-PCR Assays for microRNAs that regulate KLK5:
    hsa-miR-185 hsa-miR-4306
    SwitchGear 3'UTR luciferase reporter plasmidKLK5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLK5
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    GenScript: all cDNA clones in your preferred vector (see all 3): KLK5 (NM_001077491)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK5
    Primer
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    OriGene qPCR primer pairs and template standards for KLK5
    OriGene qSTAR qPCR primer pairs in human, mouse for KLK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLK5
      QuantiTect SYBR Green Assays in human, mouse, rat KLK5
      QuantiFast Probe-based Assays in human, mouse, rat KLK5

    Additional mRNA sequence: 

    AF168768.2 AF435980.1 AF435981.1 AK223421.1 AY279380.1 AY279381.1 AY359010.1 BC008036.2 
    BT006867.1 

    4 DOTS entries:

    DT.309895  DT.100765127  DT.95154818  DT.91744955 

    Selected AceView cDNA sequences (see all 58):

    BM840511 W73140 BM763825 AA595959 BM842755 AY279380 BM840509 BF514439 
    W68361 AY279381 W73168 AY359010 BF513278 AY461805 BM763568 NM_012427 
    BE898407 AW105502 BM845065 BG680075 BV179852 BF033594 BG680921 BM760479 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KLK5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -                                       
    SP2:                                                      
    SP3:              -     -                                 
    SP4:                    -                                 
    SP5:                                                      


    ECgene alternative splicing isoforms for KLK5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK5 expression in normal human tissues (normalized intensities)      KLK5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCCTGGAC
    KLK5 Expression
    About this image


    KLK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Epidermis (Integumentary System)
    KLK5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50915

    UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337
    Tissue specificity: Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar
    skin

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK5 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk51 , 5 kallikrein related-peptidase 51, 5 75.49(n)1
    70.45(a)1
      7 (28.30 cM)5
    686681  NM_026806.21  NP_081082.11 
     438422695 


    ENSEMBL Gene Tree for KLK5 (if available)
    TreeFam Gene Tree for KLK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK5 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK22  KLK152  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK5 using alignment to 3 protein entries:     KLK5_HUMAN (see all proteins) (see all similar genes):
    KLK11    KLK4    KLK9    KLK13    KLK14    TRY8
    PRSS1    KLK7    PRSS3    KLK12    PRSS2    KLK8
    KLK15    KLK10    KLK1    KLK2    APS    KLK3

    KLK5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KLK5
    PGOHUM00000233022


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK5 (see all 398)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107060571,2
    C--47779084(+) ATCGC-/AAAAAA 2 -- ds50012Minor allele frequency- A:0.00NA CSA 4
    rs578302351,2
    C--47783663(+) CCTACCA/-GATTT 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs796338521,2
    C--47788524(+) TCCCTG/TCCTGC 2 -- ut51 int10--------
    rs2019750071,2
    --47788524(+) TCCCT-/GCCTGC 2 -- ut51 int10--------
    rs1824759231,2
    --47790666(+) AACCCA/GAAAGG 2 -- us2k10--------
    rs26590891,2
    C--51627699(+) ATGGgG/Cccggg 1 -- ds500111Minor allele frequency- C:0.00NA WA CSA EA 372
    rs27394081,2
    C,F--51627745(+) gaggcC/Tgaggc 1 -- ds50017Minor allele frequency- T:0.21NA WA CSA 14
    rs1117193311,2
    C,F--51627751(+) GAGGCG/AGGCAG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1813858831,2
    --51627806(+) GAAACC/GCTGTT 1 -- ds50010--------
    rs25695231,2
    C,A,H--51627850(-) ggcgtG/Ccacca 1 -- ds50014Minor allele frequency- C:0.00NA CSA 6

    HapMap Linkage Disequilibrium report for KLK5 (51446559 - 51456349 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLK5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK5
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605643    OMIM disorders: --

    18 diseases for KLK5:    About MalaCards
    rosacea    netherton syndrome    testicular cancer    ovarian cancer
    oral squamous cell carcinoma    pertussis    insulinoma    bladder carcinoma
    prostate cancer    atopic dermatitis    dermatitis    prostatitis
    squamous cell carcinoma    lung cancer    influenza    breast cancer
    cerebritis    pancreatitis

    4 diseases from the University of Copenhagen DISEASES database for KLK5:
    Netherton syndrome     Rosacea     Atopic dermatitis     Ovarian cancer

    KLK5 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for KLK5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 52.6 6 11237385 (3), 15004490 (1), 12727843 (1), 12738725 (1)
    ovarian carcinoma 43.3 1 11237385 (1)
    breast cancer 12.5 4 11948967 (2), 12385949 (1), 10608802 (1)
    prostate cancer 2.52 4 11948967 (3), 15627884 (1)
    tumors 0 8 12385949 (3), 15627884 (1)
    cancer 0 3 11948967 (2), 12738725 (1)

    Genetic Association Database (GAD): KLK5
    Human Genome Epidemiology (HuGE) Navigator: KLK5 (1 document)

    Export disorders for KLK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK5 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with KLK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. (PubMed id 10514489)1, 2, 3, 9 Brattsand M. and Egelrud T. (J. Biol. Chem. 1999)
    2. The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation. (PubMed id 10608802)1, 3, 9 Yousef G.M. and Diamandis E.P. (J. Biol. Chem. 1999)
    3. SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PubMed id 19194479)1, 2, 9 Brattsand M.... Egelrud T. (J. Invest. Dermatol. 2009)
    4. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. (PubMed id 17012259)1, 3, 9 Yamasaki K....Gallo R.L. (FASEB J. 2006)
    5. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    6. Structural basis of the zinc inhibition of human tissue kallikrein 5. (PubMed id 17881000)1, 2 Debela M.... Bode W. (J. Mol. Biol. 2007)
    7. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (Biol. Chem. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2 Gan L.... Wang K. (Gene 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25818 HGNC: 6366 AceView: KLK5 Ensembl:ENSG00000167754 euGenes: HUgn25818
    ECgene: KLK5 H-InvDB: KLK5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLK5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK5 gene:
    Search GeneIP for patents involving KLK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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