KLK5 Gene

Aliases
for KLK5 gene

Previous GC identifers: GC19M052075 GC19M051807 GC19M056122 GC19M056138 GC19M047780

Summaries
for KLK5 gene

Genomic Views
for KLK5 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: KLK5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK5

KLK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051446:  view genomic region     (about GC identifiers)

Proteins
for KLK5 gene

2 PDB 3D structures from and Proteopedia for KLK5:

2PSX (3D)        2PSY (3D)    

Explore the universe of human proteins at neXtProt for KLK5: NX_Q9Y337

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for KLK5 (Kallikrein 5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: KLK5 OriGene Protein Over-expression Lysate (see all 4): KLK5 OriGene Custom Protein Services for KLK5
	GenScript Custom Purified and Recombinant Proteins Services for KLK5
	Novus Biologicals KLK5 Proteins Novus Biologicals KLK5 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for KLK5
	Uscn Proteins for KLK5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for KLK5 (Kallikrein 5)
	OriGene Antibodies (see all 2): KLK5 OriGene Custom Antibody Services for KLK5
	GenScript Custom Superior Antibodies Services for KLK5
	Novus Biologicals KLK5 Antibodies
	Search for Antibodies for KLK5 at Abcam
	Uscn Antibodies for KLK5
	ThermoFisher Antibodies for KLK5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for KLK5 (Kallikrein 5)         (see all)
	GenScript KLK5-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK5

Protein Domains /
Families
for KLK5 gene

ProtoNet protein and cluster: Q9Y337

Function
for KLK5 gene

Enzyme Numbers (IUBMB): EC 3.4.21.4² EC 3.4.21² EC 3.4.21.-¹

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK5
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK5:
		hsa-miR-185 hsa-miR-4306
		SwitchGear 3'UTR luciferase reporter plasmid: KLK5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK5 (see all 4) OriGene shRNA RFP: KLK5 OriGene siRNA: KLK5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KLK5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK5 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): KLK5 (NM_001077491)
		Sino Biological Human cDNA Clone for KLK5
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLK5
		Search LifeMap BioReagents cell lines for KLK5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK5

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for KLK5 gene

	Super-pathway	contained gene-specific pathways
1	Blood Coagulation Cascade	Blood Coagulation Cascade 1.00 Intrinsic Prothrombin Activation Pathway 0.96
2	MSP-RON Signaling	MSP-RON Signaling 1.00

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK5

	MSP-RON Signaling
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for KLK5 gene

Transcripts
for KLK5 gene

Expression
for KLK5 gene

KLK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCCTGGAC

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	PancreasIslets of LangerhansMature Beta Cells			Pancreas
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK5

Orthologs
for KLK5 gene

Paralogs
for KLK5 gene

Paralogs for KLK5 gene

KLK10²  KLK1²  KLK4²  PRSS37²  KLK11²  KLK7²  KLK14²  KLK9²  

KLK12²  KLK13²  KLK6²  KLK2²  KLK15²  PRSS1²  PRSS58²  PRSS3²  

KLK3²  KLK8²  

18/61 SIMAP similar genes for KLK5 using alignment to 3 protein entries:     KLK5_HUMAN (see all proteins) (see all similar genes):

KLK4    KLK11    KLK9    KLK13    KLK14    TRY6

TRY8    PRSS1    PRSS3    KLK7    KLK12    PRSS2

KLK8    KLK15    KLK1    KLK10    KLK2    APS

KLK5 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for KLK5
PGOHUM00000233022

Genomic Variants
for KLK5 gene

10/13 NCBI SNPs in KLK5 are shown (see all 13)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs27394101,2	F,	--	51448329(+)	ttcctT/Cccttt	1	--	int1 trp3		2		WA NA	238
rs1399112701,2	C,	--	51448340(+)	TCTCT-/CCT       TCCTCCCTTC	3	--	int1		0	--	--	--	--
rs2016936461,2	C	--	51448340(+)	GAAGGA/GGAGAG	1	--	int1		0	--	--	--	--
rs1813846201,2		--	51452633(+)	CATCTC/GCAACC	1	--	int1		0	--	--	--	--
rs1458192311,2		--	51452648(+)	CCAAAA/GCTCCA	1	--	int1		0	--	--	--	--
rs1485504311,2		--	51452672(+)	ATTCTA/GTATCT	1	--	int1		0	--	--	--	--
rs1421245501,2		--	51452685(+)	TCCCAA/GTCTCA	1	--	int1		0	--	--	--	--
rs16545401,2	C,	--	51452706(-)	AAGATG/AGCATG	1	--	int1		8		WA NA CSA EA	365
rs2689011,2	C,A,	--	51452800(-)	GGAGCG/ATATAT	1	--	int1		8		WA NA CSA EA	365
rs106501661,2	--	--	51454146(+)	tctcc-/AAaaaaa	3	--	int1 trp3		0	--	--	--	--

HapMap Linkage Disequilibrium report for KLK5 (51446559 - 51456344 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KLK5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK5

DNA2.0 Custom Variant and Variant Library Synthesis for KLK5

Disorders / Diseases
for KLK5 gene

20 diseases for KLK5

6 Novoseek disease relationships for KLK5 gene    About this table

Publications
for KLK5 gene

PubMed articles for KLK5 gene, integrated from 9 sources (see all 64): (articles sorted by number of sources associating them with KLK5)

Utopia: connect your pdf to the dynamic world of online information

1. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. (PubMed id 10514489)^{1, 2, 3, 9} Brattsand M. and Egelrud T. (1999)
2. The new kallikrein-like gene, KLK-L2. Molecular chara cterization, mapping, tissue expression, and hormonal regulation. (PubMed id 10608802)^{1, 3, 9} Yousef G.M. and Diamandis E.P. (1999)
3. SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PubMed id 19194479)^{1, 2, 9} Brattsand M.... Egelrud T. (2009)
4. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. (PubMed id 17012259)^{1, 3, 9} Yamasaki K....Gallo R.L. (2006)
5. Structural basis of the zinc inhibition of human tissue kallikrein 5. (PubMed id 17881000)^{1, 2} Debela M.... Bode W. (2007)
6. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)^{1, 3} (2006)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
9. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)^{1, 2} Gan L.... Wang K. (2000)
10. Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PubMed id 10652563)^{1, 2} Yousef G.M.... Diamandis E.P. (1999)

External Searches for KLK5 gene

Genome Databases showing KLK5 gene

Other Databases showing KLK5 gene

Specialized Databases showing KLK5 gene

Products
for KLK5 gene