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KLK4 Gene

protein-coding   GIFtS: 59
GCID: GC19M051409

Kallikrein-Related Peptidase 4

(Previous names: kallikrein 4 (prostase, enamel matrix, prostate))
(Previous symbol: PRSS17)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 41 2     ARM12
PRSS171 2 3 5     EMSP2
EMSP12 3 5     Androgen-Regulated Message 12
Enamel Matrix Serine Proteinase 12 3     Enamel Matrix Serine Protease 12
Kallikrein-Like Protein 12 3     kallikrein2
Serine Protease 172 3     kallikrein-42
KLK-L12 3     prostase2
PSTS2 3     EC 3.4.21.-3
AI2A12 5     Prostase3
Kallikrein 4 (Prostase, Enamel Matrix, Prostate)1     EC 3.4.218

External Ids:    HGNC: 63651   Entrez Gene: 96222   Ensembl: ENSG000001677497   OMIM: 6037675   UniProtKB: Q9Y5K23   

Export aliases for KLK4 gene to outside databases

Previous GC identifers: GC19M052036 GC19M051770 GC19M056085 GC19M056101 GC19M047742


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK4 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in
murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice
variants for this gene have been described, but their biological validity has not been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for KLK4 Gene:
KLK4 (kallikrein-related peptidase 4) is a protein-coding gene. Diseases associated with KLK4 include amelogenesis imperfecta, type iia1, and amelogenesis imperfecta, hypomaturation type, iia1. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
Function: Involved in enamel formation

Gene Wiki entry for KLK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK4 gene promoter:
         GR   SRF   AhR   NF-1   SRF (504 AA)   XBP-1   Arnt   GATA-1   GR-alpha   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK4 promoter sequence
   Search Chromatin IP Primers for KLK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

KLK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051409:  view genomic region     (about GC identifiers)

Start:
51,409,608 bp from pter      End:
51,413,994 bp from pter
Size:
4,387 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2 (See protein sequence)
Recommended Name: Kallikrein-4 precursor  
Size: 254 amino acids; 27032 Da
3 PDB 3D structures from and Proteopedia for KLK4:
2BDG (3D)        2BDH (3D)        2BDI (3D)    
Secondary accessions: Q4VB16 Q9GZL6 Q9UBJ6

Explore the universe of human proteins at neXtProt for KLK4: NX_Q9Y5K2

Explore proteomics data for KLK4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn169
  • 4 DME Specific Peptides for KLK4 (Q9Y5K2)
     GDSGGPL  SGGPLIC  CNGDSGGP  WVLSAAHC 


    See KLK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004908.3  
    ENSEMBL proteins: 
     ENSP00000326159   ENSP00000469963   ENSP00000469769   ENSP00000472091   ENSP00000399448  

    KLK4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9Y5K2

    ProtoNet protein and cluster: Q9Y5K2

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK4_HUMAN, Q9Y5K2
    Function: Involved in enamel formation

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity NAS10438493
    GO:0046872metal ion binding IEA--
         
    KLK4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Klk4):
     craniofacial  growth/size/body  homeostasis/metabolism  mortality/aging 

    KLK4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK4_HUMAN, Q9Y5K2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    KLK4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK4
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK4
    Interactions:

        GeneGlobe Interaction Network for KLK4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KLK4 (Q9Y5K23 ENSP000003261594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    SERPINA3P010113I2D: score=1 
    PLAURENSP000003393284STRING: ENSP00000339328
    --ENSP000002619814STRING: ENSP00000261981
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS10438493
    GO:0097186amelogenesis IMP15235027

    KLK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK4

    3 Novoseek inferred chemical compound relationships for KLK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 66.5 42 10077646 (5), 10863090 (3), 10438493 (1), 17587816 (1) (see all 15)
    progesterone 23.6 8 19147544 (3), 11344246 (2), 19190825 (1)
    estrogen 9.85 10 20009893 (3), 11344246 (2)



    KLK4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLK4 gene: 
    NM_004917.3  

    Unigene Cluster for KLK4:

    Kallikrein-related peptidase 4
    Hs.218366  [show with all ESTs]
    Unigene Representative Sequence: BU188282
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324041(uc002pty.1 uc002ptz.1 uc002pua.1 uc002pub.1 uc002puc.1 uc010eoi.1 uc002pud.1)
    ENST00000597441 ENST00000598305 ENST00000593885 ENST00000599865 ENST00000602148
    ENST00000596876 ENST00000431178
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK4
    Primer
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    OriGene qPCR primer pairs and template standards for KLK4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLK4
      QuantiTect SYBR Green Assays in human, mouse, rat KLK4
      QuantiFast Probe-based Assays in human, mouse, rat KLK4

    Additional mRNA sequence: 

    AF113140.1 AF259964.1 AF259965.1 AF259966.1 AF259967.1 AF259968.1 AF259969.1 AF259971.1 
    AK309958.1 AY923170.1 BC069325.1 BC069403.1 BC069429.1 BC069489.1 BC096175.1 BC096176.3 
    BC096177.3 BC096178.3 

    6 DOTS entries:

    DT.101980454  DT.40267708  DT.92418872  DT.99934760  DT.121410173  DT.95266046 

    Selected AceView cDNA sequences (see all 43):

    CF134924 AF113140 BC069403 BU151248 AF259969 BC069325 AF259964 AA336074 
    AF259968 AF259971 AF259967 CF147341 AF259970 CF139171 AI686689 AA603977 
    NM_004917 BC069429 BC069489 CF147425 AF126401 AF259966 AI675815 AI888156 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLK4 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                                -     -                                             
    SP2:                                      -                                             
    SP3:        -                             -                                             
    SP4:                                                                                    
    SP5:                                -     -           -     -     -                     


    ECgene alternative splicing isoforms for KLK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK4 expression in normal human tissues (normalized intensities)      KLK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGACCC
    KLK4 Expression
    About this image


    KLK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Ameloblasts Dental Enamel
             Dentin
     
     Epithelial Cells
             Inner Enamel Epithelial Cells Dental Enamel
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Prostate (Endocrine System)
    KLK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.218366

    UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
    Tissue specificity: Expressed in prostate

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK4 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk41 , 5 kallikrein related-peptidase 4 (prostase, enamel matrix, more1, 5 74.67(n)1
    68.9(a)1
      7 (28.35 cM)5
    566401  NM_019928.11  NP_064312.11 
     438811725 


    ENSEMBL Gene Tree for KLK4 (if available)
    TreeFam Gene Tree for KLK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK4 gene
    KLK102  ENSG000002697412  KLK12  PRSS372  KLK112  KLK72  KLK142  KLK92  
    KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK4 using alignment to 9 protein entries:     KLK4_HUMAN (see all proteins) (see all similar genes):
    KLK5    KLK6    KLK8    F10    HAT    KLK11
    KLK7    PRSS1    KLK14    GZMM    CFD    KLK9
    KLK12    KLK3    PRSS3    GZMB    KLK15    TRY8

    KLK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK4 (see all 190)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048947041,2
    C,Fpathogenic151411852(-) TGGCTG/AGGGTC 2 /* /W stg11Minor allele frequency- A:0.00NA 4540
    rs1164598171,2
    F--51409220(+) TTGCTG/ATCACT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1822710261,2
    --51409387(+) TCTACA/GGTTAC 1 -- ds50010--------
    rs11391321,2
    C,F--51409763(-) CAGGTC/ACCAGC 1 -- ut3110Minor allele frequency- A:0.41NA MN WA CSA EA 553
    rs16545561,2
    C,F,A,H--51409803(-) GTCCAA/GGCCCC 1 -- ut31 ese311Minor allele frequency- G:0.30MN NA WA CSA EA 558
    rs121509611,2
    C,F--51409876(+) gggggG/Atctgg 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2
    rs27394981,2
    C--51409913(+) TGGACC/TCCTGG 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs16545551,2
    C,A--51409971(-) CAGCCC/TCTCCT 1 -- ut31 ese3 trp30--------
    rs121512111,2
    C,A--51409980(+) tggACC/Tcctgg 1 -- ut31 ese30--------
    rs2022207641,2
    C--51410142(+) CCTTCC/TGCAGG 1 -- ut311Minor allele frequency- T:0.00EU 593

    HapMap Linkage Disequilibrium report for KLK4 (51409608 - 51413994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KLK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1633192CNV Deletion17803354

    Human Gene Mutation Database (HGMD): KLK4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603767   
    OMIM disorders: 204700  
    UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
  • Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1) [MIM:204700]: A defect of enamel formation. The
    disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the
    enamel is softer than normal. Brown pigment is present in middle layers of enamel. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for KLK4 (see all 23):    About MalaCards
    amelogenesis imperfecta, type iia1    amelogenesis imperfecta, hypomaturation type, iia1    urethral syndrome    amelogenesis imperfecta hypomaturation type
    dental fluorosis    dentin dysplasia    dentinogenesis imperfecta    urethritis
    endometrial carcinoma    amelogenesis imperfecta    ovarian cancer    childhood leukemia
    prostate cancer    prostatitis    meningioma    adenoma
    multiple myeloma    myeloma    obesity    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for KLK4:
    Amelogenesis imperfecta     Prostate cancer     Urethral syndrome

    KLK4 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for KLK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amelogenesis imperfecta 91.3 4 18096894 (1), 18627287 (1), 19966041 (1), 18714142 (1)
    prostate cancer 50.3 35 17545602 (5), 12370833 (3), 16322328 (3), 20180634 (3) (see all 14)
    endometrial carcinoma 36.2 2 11489814 (1), 20009893 (1)
    ovarian cancer 31.7 7 11489816 (3), 15262123 (1), 16557045 (1), 11489814 (1)
    ovarian carcinoma 31.3 7 11489814 (5), 15262123 (1), 12738725 (1)
    cancer 15.2 7 19147544 (3), 12370833 (1), 20056842 (1), 16557045 (1)
    adenoma 3.35 1 11489814 (1)
    tumors 0.1 22 11489814 (4), 11489816 (3), 12370833 (2), 18221492 (2) (see all 9)
    carcinoma 0 2 11489814 (1)

    Genetic Association Database (GAD): KLK4
    Human Genome Epidemiology (HuGE) Navigator: KLK4 (7 documents)

    Export disorders for KLK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK4 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with KLK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors. (PubMed id 10863090)1, 2, 3, 9 Hu J.C.-C.... Simmer J.P. (Gene 2000)
    2. Molecular cloning and characterization of prostase, an androgen- regulated serine protease with prostate-restricted expression. (PubMed id 10077646)1, 2, 3, 9 Nelson P.S....Wang K. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. (PubMed id 10438493)1, 2, 3, 9 Stephenson S.A.... Clements J.A. (J. Biol. Chem. 1999)
    4. Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. (PubMed id 10485467)1, 2, 9 Yousef G.M.... Diamandis E.P. (Cancer Res. 1999)
    5. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PubMed id 19372141)1, 4, 9 Lee J.Y....Kang D. (Carcinogenesis 2009)
    6. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Susceptibility loci associated with prostate cancer progression and mortality. (PubMed id 20460480)1, 4 Gallagher D.J....Offit K. (Clin. Cancer Res. 2010)
    10. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9622 HGNC: 6365 AceView: KLK4 Ensembl:ENSG00000167749 euGenes: HUgn9622
    ECgene: KLK4 H-InvDB: KLK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK4 gene:
    Search GeneIP for patents involving KLK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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