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KLK4 Gene

protein-coding GIFtS: 60

GC19M056101

kallikrein-related peptidase 4
(Previous names: kallikrein 4 (prostase, enamel matrix, prostate) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PRSS17)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARM1 ^²
EC 3.4.21.- ^³
EMSP ^¹, ²
EMSP1 ^¹, ², ³, ⁵
KLK-L1 ^¹, ², ³
MGC116827 ^²
MGC116828 ^²
PROSTASE ^²
PRSS17 ^², ³, ⁵
PSTS ^¹, ², ³
Prostase ^³

Descriptions
Enamel matrix serine proteinase 1 ^³
Kallikrein-like protein 1 ^², ³
Serine protease 17 ^³
androgen-regulated message 1 ^²
enamel matrix serine protease 1 ^²
kallikrein 4 (prostase, enamel matrix, prostate) ^¹, ²
kallikrein-related peptidase 4 ^²
protease, serine, 17 ^²

External Ids
HGNC: 6365¹
Entrez Gene: 9622²
UniProtKB: Q9Y5K2³
Ensembl: ENSG00000167749⁷

Search outside databases for aliases for KLK4 gene

Previous GC identifers: GC19M052036 GC19M051770 GC19M056085

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KLK4:

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing

evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential

as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily

members located in a cluster on chromosome 19. In some tissues its expression is hormonally

regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a

role for the protein in the degradation of enamel proteins. Alternate splice variants for this

gene have been described, but their biological validity has not been determined. [provided by

RefSeq]

Gene Wiki entry for KLK4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KLK4 gene

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-q13.4

KLK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M056101: (about GC identifiers)

Start:	56,101,420 bp from pter
End:	56,105,806 bp from pter
Size:	4,387 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2 (See protein sequence)

Recommended Name: Kallikrein-4 precursor

Size: 254 amino acids; 27023 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

2BDG (3D)

2BDH (3D)

2BDI (3D)

Secondary accessions: Q4VB16 Q9GZL6 Q9UBJ6

REFSEQ proteins: NP_004908.3

ENSEMBL proteins:

ENSP00000326159

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for KLK4 (Kallikrein 4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kallikrein 4)
	Human Recombinant Proteins from Abnova (KLK4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	10077646

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Antibodies for KLK4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KLK4
	R&D Systems Antibodies for KLK4 (Kallikrein 4)
	Antibodies from Abcam (Kallikrein 4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KLK4)
	Novus Biologicals Antibody for KLK4

Assays for KLK4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y5K2

ProtoNet protein and cluster: Q9Y5K2

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2

Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily

Similarity: Contains 1 peptidase S1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KLK4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004917

Applied Biosystems Silencer® siRNAs for KLK4

Sigma-Aldrich siRNA and siRNA Panels for KLK4

Sigma-Aldrich shRNA for KLK4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KLK4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004917
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004917
untagged cDNA clone in CMV expression vector: NM_004917

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004917

1 MGI phenotypic allele

for Klk4 (no phenotypes)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KLK4

5/8 Interacting proteins for KLK4 (ENSP00000326159³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP25	ENSP00000337816³	STRING (score=.882)
ENAM	ENSP00000254800³	STRING (score=.75)
MMP20	ENSP00000260228³	STRING (score=.75)
AMBN	ENSP00000313809³	STRING (score=.748)
AMELX	ENSP00000370088³	STRING (score=.748)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	NAS	10438493

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KLK4

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KLK4
1 Novoseek chemical compound relationship for KLK4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	27.31	8	19147544 (3), 11344246 (2), 19190825 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KLK4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004917

Sigma-Aldrich siRNA and siRNA Panels for KLK4

Sigma-Aldrich shRNA for KLK4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004917

REFSEQ mRNAs for KLK4 gene:

NM_004917.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004917

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004917
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004917
                                 untagged cDNA clone in CMV expression vector: NM_004917

Additional cDNA sequence:

AF113140.1 AF259964.1 AF259965.1 AF259966.1 AF259967.1 AF259968.1 AF259969.1 AF259971.1

AK309958.1 AY923170.1 BC069325.1 BC069403.1 BC069429.1 BC069489.1 BC096175.1 BC096176.3

BC096177.3 BC096178.3

6 DOTS entries:

DT.101980454 DT.40267708 DT.92418872 DT.99934760 DT.121410173 DT.95266046

24/43 AceView cDNA sequences (see all 43 ):

CF134924 AF113140 AI686689 BC069403 AF259970 AF259967 AI675815 AF259968

AF126401 BC069325 BC069429 AF259966 AI888156 BU151248 CF139171 AA336074

CF147341 AF259971 NM_004917 CF147425 AF259964 BC069489 AF259969 AA603977

highest scoring ESTs for KLK4:

AF113140 AF259969 BC069325 BC069403 BC069429 BC069489 AA336074 AA551449 AA552779 AA565161

Unigene Cluster for KLK4:

Kallikrein-related peptidase 4

Hs.218366 [show with all ESTs]

Unigene Representative Sequence: BU188282

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLK4 (see all 8 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c
SP1:											-		-
SP2:													-
SP3:			-										-
SP4:
SP5:											-		-				-		-		-

About this scheme

ECgene alternative splicing isoforms for KLK4

1 Ensembl transcript including schematic representation:

ENST00000324041

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KLK4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KLK4

¹ / ² / ³

7 probe-sets matching KLK4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90964_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI557281	0.60	1.00	0.82	1
224062_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF113140	0.80	1.00	0.91	1
233854_x_at²	U133-B	1	0.27	1.00	--	--	--	--	--	--	--
224062_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555697_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555737_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
233854_x_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

GeneDecks KLK4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATTGACCC

SOURCE GeneReport for Unigene cluster: Hs.218366
UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
Tissue specificity: Expressed in prostate

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KLK4 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KLK4¹	--	kallikrein-related peptidase 4	84.03(n) 76.89(a)	484354 XM_541470.2 XP_541470.2
chimpanzee (Pan troglodytes)	KLK4¹	--	kallikrein-related peptidase 4	99.61(n) 99.21(a)	469101 XM_524486.2 XP_524486.2
cow (Bos taurus)	KLK4¹	--	kallikrein-related peptidase 4	83.19(n) 78.81(a)	507800 XM_584478.3 XP_584478.3
rat (Rattus norvegicus)	Klk4¹	--	kallikrein-related peptidase 4	75.93(n) 71.03(a)	408210 NM_001004101.1 NP_001004101.1
mouse (Mus musculus)	Klk4^{1, 5}	7 (24.00 cM)⁵	kallikrein related-peptidase 4 (prostase, enamel matrix, more^{1, 5}	74.67(n)¹ 68.9(a)¹	56640¹ NM_019928.1¹ NP_064312.1¹ AF019979⁵ AF198031⁵ (see all 10)

About this table Species with no ortholog for KLK4

ENSEMBL Gene Tree for KLK4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KLK4 gene

KLK6² KLK13² KLK7² KLK5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/58 NCBI SNPs in KLK4 are shown (see all 58 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2664152^1,2	A,C,F,H	56106962(+)	`ccaggT/Gtcgta`	1	--	ng3¹		12		EU EA WA	1258
--	rs1654551^1,2	A,C,F,H	56104480(-)	`CAGGAT/GCGCTC`	1	A/S	mis¹ ese³		4		EA WA NA	352
	rs2664153^1,2	A,C,F,H	56107064(+)	`attatG/Acccca`	1	--	ng3¹ tfbs³		8		EU EA WA	840
	rs2979452^1,2	C,F,H	56106777(+)	`TTTTCT/CCTTTC`	1	--	ng3¹ tfbs³ trp³		8		EU EA WA	834
--	rs1654556^1,2	A,C,F	56101615(-)	`gtccaA/Ggcccc`	1	--	ut3¹ ese³		1		MN	184
	rs2569527^1,2	C,H	56103448(-)	`GGGCAA/CGACCA`	1	H/Q	mis¹ ese³		7		EU EA WA NA	560
	rs3760734^1,2	F,H	56107603(+)	`TTTTTA/TAAAAC`	1	--	ng3¹ tfbs³		4		EU EA WA	416
	rs34626614^1,2	C,F	56103563(+)	`TTCTGC/TCTGGG`	1	G/D	mis¹		5		NA EU EA WA	496
	rs2569526^1,2	F,H	56106299(-)	`TCCACA/GTCTCT`	1	--	ng3¹		4		EU EA WA	420
--	rs12151211^1,2	A	56101792(+)	`tggACC/Tcctgg`	1	--	ut3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KLK4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603767 disorders: 204700

UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2

Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1)

[MIM:204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves

both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel

is softer than normal. Brown pigment is present in middle layers of enamel

9 Novoseek disease relationships for KLK4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
amelogenesis imperfecta	90.90	3	18096894 (1), 18627287 (1), 18714142 (1)
prostate cancer	48.09	27	17545602 (5), 12370833 (3), 16322328 (3), 18308730 (2) (see all 11)
ovarian cancer	35.67	7	11489816 (3), 15262123 (1), 16557045 (1), 11489814 (1)
ovarian carcinoma	34.77	7	11489814 (5), 15262123 (1), 12738725 (1)
endometrial carcinoma	27.90	1	11489814 (1)
cancer	11.06	6	19147544 (3), 12370833 (1), 16557045 (1)
adenoma	7.37	1	11489814 (1)
carcinoma	0.00	2	11489814 (1)
tumors	0.00	19	11489814 (4), 11489816 (3), 12370833 (2), 18221492 (2) (see all 7)

About this table

Human Gene Mutation Database: KLK4
Human Genome Epidemiology Navigator: KLK4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/67 PubMed articles for KLK4 gene (see all 67 ):

Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors. (PubMed id 10863090)^{1, 2, 3, 4} Hu J.C....Simmer J.P. (2000)
Molecular cloning and characterization of prostase, an androgen- regulated serine protease with prostate-restricted expression. (PubMed id 10077646)^{1, 2, 3, 4} Nelson P.S....Wang K. (1999)
Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. (PubMed id 10438493)^{1, 2, 3, 4} Stephenson S.A....Clements J.A. (1999)
Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. (PubMed id 10485467)^{1, 3, 4} Yousef G.M.... Diamandis E.P. (1999)
A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)^{2, 3} Lundwall A....Yousef G.M. (2006)
Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta. (PubMed id 15235027)^{3, 4} Hart P.S....Wright J.T. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)^{3, 4} Gan L.... Wang K. (2000)
Purification, characterization, and cloning of enamel matrix serine proteinase 1. (PubMed id 9465170)^{2, 3} Simmer J.P....Bartlett J.D. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9622	HGNC: 6365	AceView: KLK4	Ensembl:ENSG00000167749	euGenes: HUgn9622
ECgene: KLK4	H-InvDB: KLK4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for KLK4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for KLK4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KLK4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KLK4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KLK4		Antibodies for KLK4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KLK4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KLK4)
	Antibodies (KLK4)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Kallikrein 4)
	Antibodies (Kallikrein 4)

Search OriGene for KLK4

Search Tocris compounds for KLK4

	Drugs for KLK4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KLK4

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KLK4 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for KLK4

Summaries
for KLK4

Genomic Location
for KLK4

Proteins
for KLK4

Protein Domains/
Families
for KLK4

Gene Function
for KLK4

Pathways & Interactions
for KLK4

Drugs & Compounds
for KLK4

Transcripts
for KLK4

Expression
for KLK4

Orthologs
for KLK4

Paralogs
for KLK4

SNPs/Variants
for KLK4

Disorders & Mutations
for KLK4

Medical News
for KLK4

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for KLK4

Search for KLK4

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KLK4 (Gene Symbol)
ARM1
EC 3.4.21.-
EMSP
EMSP1
KLK-L1
MGC116827
MGC116828
PROSTASE
PRSS17
PSTS
Prostase
Enamel matrix serine proteinase 1
Kallikrein-like protein 1
Serine protease 17
androgen-regulated message 1
enamel matrix serine protease 1
kallikrein 4 (prostase, enamel matrix, prostate)
kallikrein-related peptidase 4
protease, serine, 17

KLK4 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor KLK4

Summariesfor KLK4

Genomic Locationfor KLK4

Proteinsfor KLK4

Protein Domains/Familiesfor KLK4

Gene Functionfor KLK4

Pathways & Interactionsfor KLK4

Drugs & Compoundsfor KLK4

Transcriptsfor KLK4

Expression for KLK4

Orthologsfor KLK4

Paralogsfor KLK4

SNPs/Variantsfor KLK4

Disorders & Mutationsfor KLK4

Medical Newsfor KLK4

Publicationsfor KLK4

Search for KLK4

Genome Databases showing KLK4

Other Databases showing KLK4

Specialized Databases showing KLK4

Licensable Technologiesfor KLK4

Servicesfor KLK4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KLK4

Summaries
for KLK4

Genomic Location
for KLK4

Proteins
for KLK4

Protein Domains/
Families
for KLK4

Gene Function
for KLK4

Pathways & Interactions
for KLK4

Drugs & Compounds
for KLK4

Transcripts
for KLK4

Expression
for KLK4

Orthologs
for KLK4

Paralogs
for KLK4

SNPs/Variants
for KLK4

Disorders & Mutations
for KLK4

Medical News
for KLK4

Publications
for KLK4

Licensable Technologies
for KLK4

Services
for KLK4