Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK4 Gene

protein-coding   GIFtS: 57
GCID: GC19M051409

kallikrein-related peptidase 4

(Previous names: kallikrein 4 (prostase, enamel matrix, prostate) )
(Previous symbol: PRSS17)
 Explore 21 diseases affiliated with
KLK4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLK4    

Aliases
for KLK4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kallikrein-Related Peptidase 41 2     Kallikrein 4 (Prostase, Enamel Matrix, Prostate)1
EMSP11 2 3 5     ARM12
PRSS171 2 3 5     Androgen-Regulated Message 12
KLK-L11 2 3     Enamel Matrix Serine Protease 12
PSTS1 2 3     Kallikrein1
EMSP1 2     Kallikrein-41
Enamel Matrix Serine Proteinase 12 3     Prostase3
Kallikrein-Like Protein 12 3     EC 3.4.21.-3
Serine Protease 172 3     Prostase3
AI2A12 5     EC 3.4.218

External Ids:    HGNC: 63651   Entrez Gene: 96222   Ensembl: ENSG000001677497   OMIM: 6037675   UniProtKB: Q9Y5K23   

Export aliases for KLK4 gene to outside databases

Previous GC identifers: GC19M052036 GC19M051770 GC19M056085 GC19M056101 GC19M047742


Summaries
for KLK4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLK4:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that
many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In
some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine
developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for
this gene have been described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
Function: Involved in enamel formation

Gene Wiki entry for KLK4


Genomic Views
for KLK4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK4 gene promoter:
         GR   SRF   AhR   NF-1   SRF (504 AA)   XBP-1   Arnt   GATA-1   GR-alpha   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

KLK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051409:  view genomic region     (about GC identifiers)

Start:
 51,409,608 bp from pter      End:
 51,413,994 bp from pter
Size:
 4,387 bases      Orientation:
 minus strand

Proteins
for KLK4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2 (See protein sequence)
Recommended Name: Kallikrein-4 precursor  
Size: 254 amino acids; 27032 Da
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for KLK4:
2BDG (3D)        2BDH (3D)        2BDI (3D)    
Secondary accessions: Q4VB16 Q9GZL6 Q9UBJ6

Explore the universe of human proteins at neXtProt for KLK4: NX_Q9Y5K2

4 DME Specific Peptides for KLK4 (Q9Y5K2)
 GDSGGPL  SGGPLIC  CNGDSGGP  WVLSAAHC 

KLK4 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_004908.3  
ENSEMBL proteins: 
 ENSP00000326159   ENSP00000399448  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for KLK4 (Kallikrein 4/Prostase/EMSP1)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: KLK4
OriGene Custom Protein Services for KLK4 
GenScript Custom Purified and Recombinant Proteins Services for KLK4
Novus Biologicals KLK4 Proteins
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for KLK4
Uscn Proteins for KLK4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--


KLK4 for ontologies           About GeneDecksing



KLK4 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for KLK4 (Kallikrein 4/Prostase/EMSP1)
Browse OriGene Antibodies
OriGene Custom Antibody Services for KLK4 
GenScript Custom Superior Antibodies Services for KLK4
Novus Biologicals KLK4 Antibodies
Abcam antibodies for KLK4 
Uscn Antibodies for KLK4
ThermoFisher Antibodies for KLK4

Assay Products for KLK4: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for KLK4
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for KLK4

Protein Domains /
Families
for KLK4 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
KLK4 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry Q9Y5K2

ProtoNet protein and cluster: Q9Y5K2

2 Blocks protein families:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
Similarity: Contains 1 peptidase S1 domain


Function
for KLK4 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
Function: Involved in enamel formation

Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

miRNA
Products:    		 OriGene 3'-UTR Clone: KLK4
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK4
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLK4
SwitchGear 3'UTR luciferase reporter plasmid: KLK4 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK4 (see all 7)
OriGene shRNA RFP: KLK4
OriGene siRNA: KLK4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK4

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for KLK4

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: KLK4 (NM_004917)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK4 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for KLK4
Search LifeMap BioReagents cell lines for KLK4

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004252serine-type endopeptidase activity IEA--
GO:0008236serine-type peptidase activity NAS10438493
GO:0046872metal ion binding IEA--


KLK4 for ontologies           About GeneDecksing


Animal Models:
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Klk4):
 craniofacial  growth/size  homeostasis/metabolism  mortality/aging 

KLK4 for phenotypes           About GeneDecksing


Pathways & Interactions
for KLK4 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Blood Coagulation Cascade
Blood Coagulation Cascade1.00
Intrinsic Prothrombin Activation Pathway0.96
2MSP-RON Signaling
MSP-RON Signaling1.00

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK4
    MSP-RON Signaling
Blood Coagulation Cascade
Intrinsic Prothrombin Activation Pathway


Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLK4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for KLK4 (Q9Y5K23 ENSP000003261594) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
SERPINA3P010113I2D: score=1 
PLAURENSP000003393284STRING: ENSP00000339328
--ENSP000002619814STRING: ENSP00000261981
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis NAS10438493
GO:0097186amelogenesis IMP15235027


KLK4 for ontologies           About GeneDecksing



Drugs & Compounds
for KLK4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KLK4 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLK4
3 Novoseek chemical compound relationships for KLK4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
serine 66.5 42 10077646 (5), 10863090 (3), 10438493 (1), 17587816 (1) (see all 15)
progesterone 23.6 8 19147544 (3), 11344246 (2), 19190825 (1)
estrogen 9.85 10 20009893 (3), 11344246 (2)

Search CenterWatch for drugs/clinical trials and news about KLK4 

Transcripts
for KLK4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for KLK4 gene: 
NM_004917.3  

Unigene Cluster for KLK4:

Kallikrein-related peptidase 4
Hs.218366  [show with all ESTs]
Unigene Representative Sequence: BU188282
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000324041(uc002pty.1 uc002ptz.1 uc002pua.1 uc002pub.1 uc002puc.1 uc010eoi.1 uc002pud.1)
ENST00000431178

miRNA
Products:     		 OriGene 3'-UTR Clone: KLK4
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK4
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLK4
SwitchGear 3'UTR luciferase reporter plasmid: KLK4 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK4 (see all 7)
OriGene shRNA RFP: KLK4
OriGene siRNA: KLK4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK4
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: KLK4 (NM_004917)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK4 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK4

Additional cDNA sequence: 

AF113140.1 AF259964.1 AF259965.1 AF259966.1 AF259967.1 AF259968.1 AF259969.1 AF259971.1 
AK309958.1 AY923170.1 BC069325.1 BC069403.1 BC069429.1 BC069489.1 BC096175.1 BC096176.3 
BC096177.3 BC096178.3 

6 DOTS entries:

DT.101980454  DT.40267708  DT.92418872  DT.99934760  DT.121410173  DT.95266046 

24/43 AceView cDNA sequences (see all 43):

CF134924 AF113140 AF259970 AF259967 AA336074 AF259969 BU151248 AA603977 
AI888156 AF126401 CF147341 BC069403 AI675815 AF259964 NM_004917 CF147425 
AF259966 CF139171 AI686689 AF259971 AF259968 BC069325 BC069429 BC069489 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLK4 (see all 8)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1:                                -     -                                             
SP2:                                      -                                             
SP3:        -                             -                                             
SP4:                                                                                    
SP5:                                -     -           -     -     -                     


ECgene alternative splicing isoforms for KLK4

Expression
for KLK4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTGACCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

KLK4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
TestisSeminiferous TubulesSertoli cellsTestis
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See KLK4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLK4

SOURCE GeneReport for Unigene cluster: Hs.218366

UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
Tissue specificity: Expressed in prostate

    SABiosciences Custom PCR Arrays for KLK4
Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK4
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK4

Orthologs
for KLK4 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for KLK4 gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
--
(see all 4)		 --
 39(a)
37(a)
(see all 4)		 1 ↔ many
possible ortholog
(see all 4)		 GL343276.1(1578128-1583778)
GL343276.1(1637722-1647419)
zebrafish
(Danio rerio)		 Actinopterygii zgc:663826
si:ch73-103b2.36
 si:ch73-103b2.3
 35(a)
34(a)
 many ↔ many
many ↔ many
 16(28253006-28254288)
16(28257799-28259131)


ENSEMBL Gene Tree for KLK4 (if available)
TreeFam Gene Tree for KLK4 (if available) 

Paralogs
for KLK4 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KLK4 gene
KLK102  KLK12  PRSS372  KLK112  KLK72  KLK142  KLK92  KLK122  
KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  PRSS32  
KLK32  KLK82  
18/112 SIMAP similar genes for KLK4 using alignment to 9 protein entries:     KLK4_HUMAN (see all proteins) (see all similar genes):
KLK5    KLK6    KLK8    F10    KLK7    HAT
KLK11    PRSS1    GZMM    KLK14    KLK12    CFD
KLK9    PRSS48    PRSS3    TRY6    TRY8    GZMB

KLK4 for paralogs           About GeneDecksing



Genomic Variants
for KLK4 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/151 NCBI SNPs in KLK4 are shown (see all 151)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 19 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1048947041,2
C,F,pathogenic51411852(-) TGGCTG/AGGGTC 2 /* /W stg11Minor allele frequency- A:0.00NA 4540
rs1164598171,2
F,--51409220(+) TTGCTG/ATCACT 1 -- ds50011Minor allele frequency- A:0.02WA 118
rs1822710261,2
--51409387(+) TCTACA/GGTTAC 1 -- ds50010--------
rs11391321,2
C,F,--51409763(-) CAGGTC/ACCAGC 1 -- ut3110Minor allele frequency- A:0.41NA MN WA CSA EA 553
rs16545561,2
C,A,H,--51409803(-) gtccaA/Ggcccc 1 -- ut31 ese311Minor allele frequency- G:0.30MN NA WA CSA EA 558
rs121509611,2
--51409876(+) gggggG/Atctgg 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2
rs27394981,2
C--51409913(+) TGGACC/TCCTGG 1 -- ut311Minor allele frequency- T:0.50WA 2
rs16545551,2
C,A--51409971(-) CAGCCC/TCTCCT 1 -- ut31 ese3 trp30--------
rs121512111,2
C,A--51409980(+) tggACC/Tcctgg 1 -- ut31 ese30--------
rs730423871,2
C,F,--51410171(+) TTCATG/AGGTTC 1 -- ut313Minor allele frequency- A:0.11WA NA EU 1557

HapMap Linkage Disequilibrium report for KLK4 (51409608 - 51413994 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KLK4: --
Human Gene Mutation Database (HGMD): KLK4

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK4
DNA2.0 Custom Variant and Variant Library Synthesis for KLK4

Disorders / Diseases
for KLK4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
KLK4 for disorders           About GeneDecksing

OMIM gene information: 603767   
OMIM disorders: 204700  
UniProtKB/Swiss-Prot: KLK4_HUMAN, Q9Y5K2
  • Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700]. AI2A1
    • is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The
    teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle
    layers of enamel

    20/21 diseases for KLK4 (see all 21):    About MalaCards
    amelogenesis imperfecta    amelogenesis imperfecta, type iia1    amelogenesis imperfecta hypomaturation type    dental fluorosis
    dentinogenesis imperfecta    prostatitis    dentin dysplasia    epithelial ovarian cancer
    endometrial carcinoma    ovarian cancer    ovarian carcinoma    prostate cancer
    prostate cancer, progression of    endometrial cancer    carcinoma    colon cancer
    meningioma    breast cancer    tuberculosis    pancreatitis

    3 diseases from the University of Copenhagen DISEASES database for KLK4:
    Amelogenesis imperfecta     Prostate cancer     Urethral syndrome

    9 Novoseek disease relationships for KLK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amelogenesis imperfecta 91.3 4 18096894 (1), 18627287 (1), 19966041 (1), 18714142 (1)
    prostate cancer 50.3 35 17545602 (5), 12370833 (3), 16322328 (3), 20180634 (3) (see all 14)
    endometrial carcinoma 36.2 2 11489814 (1), 20009893 (1)
    ovarian cancer 31.7 7 11489816 (3), 15262123 (1), 16557045 (1), 11489814 (1)
    ovarian carcinoma 31.3 7 11489814 (5), 15262123 (1), 12738725 (1)
    cancer 15.2 7 19147544 (3), 12370833 (1), 20056842 (1), 16557045 (1)
    adenoma 3.35 1 11489814 (1)
    tumors 0.1 22 11489814 (4), 11489816 (3), 12370833 (2), 18221492 (2) (see all 9)
    carcinoma 0 2 11489814 (1)

    Human Genome Epidemiology (HuGE) Navigator: KLK4 (7 documents)

    Export disorders for KLK4 gene to outside databases

    Publications
    for KLK4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLK4 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with KLK4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors. (PubMed id 10863090)1, 2, 3, 9 Hu J.C.-C.... Simmer J.P. (2000)
    2. Molecular cloning and characterization of prostase, an androgen- regulated serine protease with prostate-restricted expression. (PubMed id 10077646)1, 2, 3, 9 Nelson P.S....Wang K. (1999)
    3. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. (PubMed id 10438493)1, 2, 3, 9 Stephenson S.A.... Clements J.A. (1999)
    4. Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. (PubMed id 10485467)1, 2, 9 Yousef G.M.... Diamandis E.P. (1999)
    5. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)
    6. Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta. (PubMed id 15235027)1, 2 Hart P.S....Wright J.T. (2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2 Gan L.... Wang K. (2000)
    10. Purification, characterization, and cloning of enamel matrix serine proteinase 1. (PubMed id 9465170)1, 3 Simmer J.P....Bartlett J.D. (1998)

    External Searches for KLK4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KLK4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9622 HGNC: 6365 AceView: KLK4 Ensembl:ENSG00000167749 euGenes: HUgn9622
    ECgene: KLK4 H-InvDB: KLK4

    Other Databases showing KLK4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLK4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KLK4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLK4 gene:
    Search GeneIP for patents involving KLK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KLK4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KLK4 (Kallikrein 4/Prostase/EMSP1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for KLK4 (Kallikrein 4/Prostase/EMSP1)  
     Browse OriGene Antibodies   OriGene shRNA RFP for KLK4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK4  
     OriGene Protein Over-expression Lysate for KLK4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KLK4   OriGene 3'-UTR Clone for KLK4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLK4   OriGene Custom Protein Services for KLK4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLK4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK4
     GenScript Custom Purified and Recombinant Proteins Services for KLK4 GenScript cDNA clones with any tag delivered in your preferred vector for KLK4
     GenScript Custom Assay Services for KLK4 GenScript Custom Superior Antibodies Services for KLK4
     GenScript Custom overexpressing Cell Line Services for KLK4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLK4 promoter
     Search Chromatin IP Primers for KLK4
     RT2 qPCR Primer Assay in human, mouse, rat KLK4
     GNC Network for KLK4
     SABiosciences PCR Arrays including human, mouse, rat KLK4
     Search Tocris compounds for KLK4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLK4 antibodies
     KLK4 proteins
     Antibodies for KLK4
     See all of Abcam's Antibodies, Kits and Proteins for KLK4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for KLK4




     KLK4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KLK4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK4
     SwitchGear 3'UTR luciferase reporter plasmids for KLK4
     SwitchGear Promoter luciferase reporter plasmids for KLK4
     ThermoFisher Antibodies for KLK4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KLK4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4