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Aliases for KLK3 Gene

Aliases for KLK3 Gene

  • Kallikrein-Related Peptidase 3 2 3
  • PSA 3 4 6
  • APS 3 4 6
  • Gamma-Seminoprotein 3 4
  • P-30 Antigen 3 4
  • Kallikrein-3 3 4
  • Semenogelase 3 4
  • Seminin 3 4
  • Kallikrein 3, (Prostate Specific Antigen) 2
  • Prostate Specific Antigen 3
  • Prostate-Specific Antigen 3
  • EC 4
  • EC 3.4.21 63
  • KLK2A1 3
  • HK3 3

External Ids for KLK3 Gene

Previous HGNC Symbols for KLK3 Gene

  • APS

Previous GeneCards Identifiers for KLK3 Gene

  • GC19P051987
  • GC19P051719
  • GC19P056034
  • GC19P056049
  • GC19P051358
  • GC19P047693

Summaries for KLK3 Gene

Entrez Gene Summary for KLK3 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK3 Gene

KLK3 (Kallikrein-Related Peptidase 3) is a Protein Coding gene. Diseases associated with KLK3 include fletcher factor deficiency and prostatitis. Among its related pathways are Pathways in cancer and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK3 Gene

  • Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Gene Wiki entry for KLK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK3 Gene

Genomics for KLK3 Gene

Regulatory Elements for KLK3 Gene

Transcription factor binding sites by QIAGEN in the KLK3 gene promoter:

Genomic Location for KLK3 Gene

50,854,915 bp from pter
50,860,764 bp from pter
5,850 bases
Plus strand

Genomic View for KLK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK3 Gene

Proteins for KLK3 Gene

  • Protein details for KLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prostate-specific antigen
    Protein Accession:
    Secondary Accessions:
    • C9JXH3
    • G3V0H4
    • G3XAE3
    • Q15096
    • Q16272
    • Q86TG8
    • Q8IXI4

    Protein attributes for KLK3 Gene

    261 amino acids
    Molecular mass:
    28741 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5.
    • Sequence=AAD14185.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA32124.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KLK3 Gene

    Alternative splice isoforms for KLK3 Gene


neXtProt entry for KLK3 Gene

Proteomics data for KLK3 Gene at MOPED

Selected DME Specific Peptides for KLK3 Gene

Post-translational modifications for KLK3 Gene

  • Glycosylation at Asn69
  • Modification sites at PhosphoSitePlus

Domains for KLK3 Gene

Gene Families for KLK3 Gene

  • KLK :Kallikreins

Graphical View of Domain Structure for InterPro Entry



  • P07288
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK3: view

Function for KLK3 Gene

Molecular function for KLK3 Gene

GENATLAS Biochemistry: kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast carcinomas
UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: -Tyr- -Xaa-
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders.
UniProtKB/Swiss-Prot Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Enzyme Numbers (IUBMB) for KLK3 Gene

Gene Ontology (GO) - Molecular Function for KLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 1725227
GO:0008236 serine-type peptidase activity TAS 2470553
genes like me logo Genes that share ontologies with KLK3: view

Phenotypes for KLK3 Gene

GenomeRNAi human phenotypes for KLK3:
genes like me logo Genes that share phenotypes with KLK3: view

miRNA for KLK3 Gene

miRTarBase miRNAs that target KLK3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for KLK3 Gene

Localization for KLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK3 Gene


Subcellular locations from

Jensen Localization Image for KLK3 Gene COMPARTMENTS Subcellular localization image for KLK3 gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21630459
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KLK3: view

Pathways for KLK3 Gene

genes like me logo Genes that share pathways with KLK3: view

Gene Ontology (GO) - Biological Process for KLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016525 negative regulation of angiogenesis NAS 10675891
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with KLK3: view

Compounds for KLK3 Gene

(123) Novoseek inferred chemical compound relationships for KLK3 Gene

Compound -log(P) Hits PubMed IDs
estramustine 89.2 50
bicalutamide 87.7 101
testosterone 86.5 425
estramustine phosphate 83.9 36
cpsa 83.3 98
genes like me logo Genes that share compounds with KLK3: view

Transcripts for KLK3 Gene

Unigene Clusters for KLK3 Gene

Kallikrein-related peptidase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10: - - -
SP11: - -
SP12: - - - -
SP13: - - - - -

Relevant External Links for KLK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK3 Gene

mRNA expression in normal human tissues for KLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK3 Gene

This gene is overexpressed in Prostate (52.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLK3 Gene

SOURCE GeneReport for Unigene cluster for KLK3 Gene Hs.171995

genes like me logo Genes that share expressions with KLK3: view

No data available for mRNA Expression by UniProt/SwissProt for KLK3 Gene

Orthologs for KLK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLK3 36
  • 92 (a)
(Bos Taurus)
Mammalia -- 36
  • 27 (a)
(Canis familiaris)
Mammalia KLK2 36
  • 56 (a)
(Mus musculus)
Mammalia Klk1b16 36
  • 51 (a)
Klk1b22 35
  • 65.49 (n)
  • 56.86 (a)
Klk1b27 16
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
Species with no ortholog for KLK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK3 Gene

Gene Tree for KLK3 (if available)
Gene Tree for KLK3 (if available)

Paralogs for KLK3 Gene

genes like me logo Genes that share paralogs with KLK3: view

Variants for KLK3 Gene

Sequence variations from dbSNP and Humsavar for KLK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs6998 -- 50,860,405(+) GTGGG(A/G)TACAG utr-variant-3-prime
rs11573 -- 50,856,241(+) GCAGG(C/T)GCTGC synonymous-codon, reference, upstream-variant-2KB
rs12040 -- 50,860,571(+) CTGGG(A/G)AGCCT utr-variant-3-prime
rs12101 -- 50,860,372(+) GGACA(C/G/T)AGATA utr-variant-3-prime
rs12863 -- 50,860,642(+) AGGAG(A/G)GGGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLK3 Gene

Variant ID Type Subtype PubMed ID
nsv2531 CNV Loss 18451855
nsv524465 CNV Loss 19592680

Relevant External Links for KLK3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK3 Gene

Disorders for KLK3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (23) Diseases for KLK3 Gene including...

Search for KLK3 Gene in MalaCards »

(94) Novoseek inferred disease relationships for KLK3 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 98.8 643
prostate carcinoma 94.2 289
benign prostatic hyperplasia 93.6 218
prostatic adenocarcinoma 91.5 119
recurrent prostate cancer 89.2 52

Relevant External Links for KLK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLK3: view

No data available for UniProtKB/Swiss-Prot for KLK3 Gene

Publications for KLK3 Gene

  1. A structural model for the prostate disease marker, human prostate- specific antigen. (PMID: 7535613) Villoutreix B.O. … Griffin J.H. (Protein Sci. 1994) 3 4 23
  2. Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors. (PMID: 7527295) Monne M. … Diamandis E.P. (Cancer Res. 1994) 3 4 23
  3. Substrate specificity of prostate-specific antigen (PSA). (PMID: 9751643) Coombs G.S. … Corey D.R. (Chem. Biol. 1998) 3 4 23
  4. Novel polymorphisms in prostate specific antigen gene and its association with prostate cancer. (PMID: 11299734) Yang Q. … Kakudo K. (Anticancer Res. 2001) 3 23 48
  5. Polymorphic CAG repeats in the androgen receptor gene, prostate-specific antigen polymorphism and prostate cancer risk. (PMID: 12376473) Gsur A. … Micksche M. (Carcinogenesis 2002) 3 23 48

Products for KLK3 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Endothelial Cell Biology in human,mouse,rat
    • Estrogen Receptor Signaling in human,mouse,rat
    • Prostate Cancer in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KLK3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK3
  • Block miRNA regulation of KLK3 using miScript Target Protectors

Sources for KLK3 Gene

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