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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLK3 Gene

protein-coding GIFtS: 70
GCID: GC19P051358

kallikrein-related peptidase 3

(Previous names: kallikrein 3, (prostate specific antigen) )
(Previous symbol: APS)

Explore 120 diseases affiliated with
KLK3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 3¹ ²		Prostate-Specific Antigen²
APS¹ ² ³ ⁵		Semenogelase³
PSA¹ ² ³ ⁵		Seminin³
P-30 Antigen² ³		EC 3.4.21.77³
Kallikrein 3, (Prostate Specific Antigen)¹		Gamma-Seminoprotein¹
KLK2A1²		Kallikrein-3³
Gamma-Seminoprotein¹		Semenogelase³
HK3¹		Seminin³
Kallikrein-3³		EC 3.4.21⁸
Prostate Specific Antigen²

External Ids:	HGNC: 6364¹	Entrez Gene: 354²	Ensembl: ENSG00000142515⁷	OMIM: 176820⁵	UniProtKB: P07288³

Export aliases for KLK3 gene to outside databases

Previous GC identifers: GC19P051987 GC19P051719 GC19P056034 GC19P056049 GC19P047693

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK3:

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that

many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease

biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its

protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of

seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this

protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma.

Alternate splicing of this gene generates several transcript variants encoding different isoforms. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Gene Wiki entry for KLK3 (Prostate-specific antigen)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLK3 gene promoter:
STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLK3 promoter sequence

Search SABiosciences Chromatin IP Primers for KLK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.41

KLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P051358: view genomic region (about GC identifiers)

Start:	51,358,171 bp from pter	End:	51,364,020 bp from pter
Size:	5,850 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288 (See protein sequence)

Recommended Name: Prostate-specific antigen precursor

Size: 261 amino acids; 28741 Da

Subunit: Forms a heterodimer with SERPINA5

Subcellular location: Secreted

Sequence caution: Sequence=AAD14185.1; Type=Erroneous initiation;

6 PDB 3D structures from and Proteopedia for KLK3:

1PFA (3D)

2PSA (3D)

2ZCH (3D)

2ZCK (3D)

2ZCL (3D)

3QUM (3D)

Secondary accessions: C9JXH3 G3V0H4 G3XAE3 Q15096 Q16272 Q86TG8

Alternative splicing: 4 isoforms: P07288-1 P07288-2 P07288-3 P07288-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLK3: NX_P07288

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07288

4/9 DME Specific Peptides for KLK3 (P07288) (see all 9)

CGGVLVH

SGGPLVC

GVLQGIT

GDSGGPL

KLK3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001025218.1 NP_001025219.1 NP_001025221.1 NP_001639.1

ENSEMBL proteins:

ENSP00000314151 ENSP00000393628 ENSP00000353829 ENSP00000401523

Reactome Protein details: P07288
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant KLK3 Protein
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	ProSpec Recombinant Protein for KLK3
	Uscn Proteins for KLK3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--

KLK3 for ontologies About GeneDecksing

KLK3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KLK3
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	Novus Biologicals KLK3 Antibodies
	Abcam antibodies for KLK3
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	ThermoFisher Antibody for KLK3

Assay Products for KLK3:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for KLK3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLK3 for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P07288

ProtoNet protein and cluster: P07288

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Catalytic activity: Preferential cleavage: -Tyr- -Xaa-

Enzyme regulation: Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than

in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders

Genatlas biochemistry entry for KLK3:

kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast carcinomas

Enzyme Numbers (IUBMB): EC 3.4.21.77¹ EC 3.4.21²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): KLK3 Browse MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate KLK3:
		hsa-miR-661
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Gene Editing
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		Search LifeMap BioReagents cell lines for KLK3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	NAS	--
GO:0005515	protein binding	IPI	1725227
GO:0008236	serine-type peptidase activity	TAS	2470553

KLK3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KLK3:

Increased cell death HMECs cel

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Cell adhesion_ECM remodeling

Cell adhesion ECM remodeling

1.00

Cell adhesion_ECM remodeling

1.00

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Intrinsic Prothrombin Activation Pathway

0.96

Protein Stability

Protein Stability

1.00

Adhesion

Adhesion

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for KLK3

	Transcription Androgen Receptor nuclear signaling
	Cell adhesion ECM remodeling

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK3

	MSP-RON Signaling
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

2 Cell Signaling Technology (CST) Pathways for KLK3

	Adhesion
	Protein Stability

2 GeneGo (Thomson Reuters) Pathways for KLK3

	Transcription Androgen Receptor nuclear signaling
	Cell adhesion ECM remodeling

4 BioSystems Pathways for KLK3

	Androgen receptor signaling pathway
	Regulation of Androgen receptor activity
	FOXA1 transcription factor network
	Coregulation of Androgen receptor activity

2 Reactome Pathways for KLK3

	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Metabolism of proteins

2 Kegg Pathways (Kegg details for KLK3):

	Pathways in cancer
	Prostate cancer

KLK3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLK3

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/25 Interacting proteins for KLK3 (P07288³ ENSP00000314151⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SERPINA1	P01009³, ENSP00000348068⁴	I2D: score=3 STRING: ENSP00000348068
AR	P10275³, ENSP00000363822⁴	I2D: score=2 STRING: ENSP00000363822
FN1	P02751³, ENSP00000346839⁴	I2D: score=2 STRING: ENSP00000346839
SERPINA5	P05154³, ENSP00000333203⁴	I2D: score=2 STRING: ENSP00000333203
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=1 STRING: ENSP00000262367

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	NAS	--
GO:0016525	negative regulation of angiogenesis	NAS	10675891

KLK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KLK3 for compounds About GeneDecksing

EMD Millipore small molecules for KLK3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLK3
10/123 Novoseek chemical compound relationships for KLK3 gene (see all 123) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estramustine	89.2	63	17942366 (4), 10076535 (3), 10687988 (3), 16729913 (2) (see all 39)
bicalutamide	87.7	158	9112515 (6), 7513530 (5), 15134983 (3), 19902465 (3) (see all 70)
testosterone	86.5	2207	18843272 (11), 11421528 (9), 12539223 (9), 7541588 (7) (see all 99)
estramustine phosphate	83.9	49	18634439 (5), 16882080 (5), 16037707 (4), 7542158 (3) (see all 19)
cpsa	83.3	257	11834399 (6), 10736503 (5), 10759671 (4), 12384160 (4) (see all 52)
flutamide	83.1	186	11706524 (7), 8558675 (7), 9112515 (6), 10705202 (6) (see all 71)
finasteride	80.7	389	9426721 (10), 9586598 (9), 9218012 (9), 9649261 (8) (see all 99)
pt-2a	80.7	12	15073852 (4), 11176395 (1), 15711264 (1), 10569562 (1) (see all 7)
docetaxel	79.8	226	19575420 (6), 18487550 (4), 18990177 (4), 19920389 (4) (see all 99)
prostascint	78.9	28	10617872 (3), 11920467 (2), 11113745 (2), 10850293 (2) (see all 15)

Search CenterWatch for drugs/clinical trials and news about KLK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLK3 gene (5 alternative transcripts):

NM_001030047.1 NM_001030048.1 NM_001030050.1 NM_001648.2 NM_001030049.1

Unigene Cluster for KLK3:

Kallikrein-related peptidase 3

Hs.171995 [show with all ESTs]

Unigene Representative Sequence: AF335478

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000326003(uc021uyi.1 uc010eof.1) ENST00000422986(uc002ptr.1)

ENST00000360617(uc002pts.1) ENST00000435152(uc002ptp.1)

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate KLK3:
		hsa-miR-661
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK3 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK3

Additional cDNA sequence:

AF335477.1 AF335478.1 AJ310937.1 AJ310938.1 AJ459782.1 AJ459783.1 AJ459784.1 AJ512346.1

AK311887.1 AK312933.1 BC005307.1 BC050595.2 BC056665.1 BT019862.1 DQ641251.1 M21895.1

M21896.1 M21897.1 M26663.1 S75755.1 U17040.1 X05332.1 X07730.1 X75682.1

24/57 DOTS entries (see all 57):

DT.92412919 DT.92461817 DT.101987510 DT.95208239 DT.455621 DT.87016872 DT.92029956 DT.92461821

DT.100060506 DT.87016874 DT.95208245 DT.95208246 DT.95208227 DT.87002147 DT.92367459 DT.87079599

DT.121490621 DT.95208221 DT.455618 DT.121490734 DT.100735196 DT.206121 DT.91966580 DT.100643341

24/1035 AceView cDNA sequences (see all 1035):

BF447250 CA487655 BF477158 BQ925109 BQ884242 NM_145864 BF001040 AI989309

BF477115 BF477225 BX099872 NM_001002232 CA495379 AA595609 BQ950477 AI399635

BQ940694 CF141484 BF063478 AA729122 CA487643 AI028305 CA488067 CA488903

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KLK3 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f
SP1:											-		-		-										-								-		-
SP2:													-		-										-								-		-
SP3:											-		-		-						-				-								-
SP4:											-		-		-						-				-								-		-
SP5:											-		-		-										-								-

ECgene alternative splicing isoforms for KLK3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATGGGGAT

About this image

KLK3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See KLK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLK3

SOURCE GeneReport for Unigene cluster: Hs.171995

SABiosciences Expression via Pathway-Focused PCR Arrays including KLK3:

Estrogen Receptor Signaling in human mouse rat

Endothelial Cell Biology in human mouse rat

Angiogenic Growth Factors in human mouse rat

Prostate Cancer in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KLK3 gene from 2/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	41(a) 36(a) (see all 4)	1 ↔ many possible ortholog (see all 4)	GL343276.1(1578128-1583778) GL343276.1(1637722-1647419)
zebrafish (Danio rerio)	Actinopterygii	zgc:66382⁶ si:ch73-103b2.3⁶	si:ch73-103b2.3	39(a) 38(a)	many ↔ many many ↔ many	16(28253006-28254288) 16(28257799-28259131)

ENSEMBL Gene Tree for KLK3 (if available)
TreeFam Gene Tree for KLK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLK3 gene

KLK10² KLK1² KLK4² PRSS37² KLK11² KLK7² KLK14² KLK9²

KLK12² KLK13² KLK6² KLK2² KLK15² KLK5² PRSS1² PRSS58²

PRSS3² KLK8²

18/74 SIMAP similar genes for KLK3 using alignment to 11 protein entries: KLK3_HUMAN (see all proteins) (see all similar genes):

APS KLK2 KLK1 KLK9 KLK11 KLK5

KLK7 KLK4 KLK13 AZU1 KLK6 TMPRSS6

PRSS1 PRSS3 KLK8 GZMK PRSS2 TRY8

KLK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs266860^1,2		--	47691227(+)	`ggagtA/Gcagtg`	4	--	us2k¹		0	--	--	--	--
rs76151346^1,2	C,	--	47691619(+)	`GTTCCC/TGATTC`	4	--	us2k¹		2		WA	120
rs78722548^1,2	C,	--	47691667(+)	`TTAATC/TTTTTT`	4	--	us2k¹		0	--	--	--	--
rs56263846^1,2		--	47691867(+)	`GGCACA/CGTGGC`	4	--	us2k¹		0	--	--	--	--
rs2739450^1,2	C,F,	--	47692017(+)	`GCACAC/TGGCAC`	4	--	us2k¹		8		NA CSA WA EA	367
rs10423062^1,2	C,A,H	--	47692159(+)	`aaaaaA/Tttttt`	4	--	us2k¹ trp³		0	--	--	--	--
rs2739451^1,2	C,F,A,H,	--	47692201(+)	`gtttcT/Cctggt`	4	--	us2k¹		27		NS EA NA CSA WA	3186
rs73050317^1,2	C,F,	--	47692392(+)	`ACCTGG/TGAGGG`	4	--	us2k¹		1		MN	152
rs266882^1,2	C,F,A,H,	--	47692944(+)	`CAAGTG/ACTAGC`	4	--	us2k¹		21		MN WA EA NA CSA	1731
rs266881^1,2	C,F,A,H,	--	47693264(+)	`CCCCCC/AAACCC`	4	--	int¹ trp³		23		EA MN NS NA WA CSA	2841

HapMap Linkage Disequilibrium report for KLK3 (51358171 - 51364020 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLK3: --
Human Gene Mutation Database (HGMD): KLK3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLK3 for disorders           About GeneDecksing

OMIM gene information: 176820    OMIM disorders: --

20/120 diseases for KLK3 (see all 120):    About MalaCards

prostatitis prostate carcinoma spinal cord injury urethral stricture

carcinoma cranial nerve palsy disseminated intravascular coagulation polyarteritis nodosa

urinary tract obstruction urinary tract infection sphenoid sinusitis intraepithelial neoplasm

growth hormone deficiency nephrogenic adenoma nephrogenic adenoma of the urethra androgenetic alopecia

disorders of sex development back pain non-hodgkin lymphoma type 2 diabetes mellitus

16 diseases from the University of Copenhagen DISEASES database for KLK3:

Prostate cancer Carcinoma Prostatitis Prostatic hypertrophy

Urethral stricture Sexual dysfunction Penile disease Prostatic adenoma

Proctitis Gynecomastia Neutropenia Hypogonadism

Urinary bladder cancer Withdrawal disorder Lymphocele Breast cancer

10/94 Novoseek disease relationships for KLK3 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	98.8	14595	9372881 (10), 11391681 (9), 12187207 (9), 7537603 (9) (see all 99)
prostate carcinoma	94.2	1143	10951348 (6), 16419068 (6), 8847816 (5), 15578715 (5) (see all 99)
benign prostatic hyperplasia	93.6	1011	9674713 (6), 8791046 (4), 15044396 (4), 7516808 (3) (see all 99)
prostatic adenocarcinoma	91.5	266	7525979 (5), 17963516 (3), 8958315 (2), 11106075 (2) (see all 99)
recurrent prostate cancer	89.2	69	9126236 (2), 9338734 (2), 16609031 (2), 1279216 (1) (see all 49)
prostatic diseases	88.9	229	7551887 (3), 11720279 (3), 12394676 (3), 7685140 (3) (see all 99)
prostatic intraepithelial neoplasia	88.6	187	10524873 (8), 7686984 (7), 8709305 (4), 7541850 (3) (see all 81)
androgen suppression	87.7	91	9166947 (4), 10477903 (4), 14712491 (3), 11685725 (2) (see all 49)
cancer	87.1	3881	7514689 (8), 11743285 (7), 1283897 (7), 9145718 (7) (see all 99)
stage prostate cancer	86.3	61	11999465 (2), 18411775 (2), 9649289 (2), 14675918 (1) (see all 44)

Genetic Association Database (GAD): KLK3
Human Genome Epidemiology (HuGE) Navigator: KLK3 (144 documents)

Export disorders for KLK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KLK3 gene, integrated from 9 sources (see all 3717):
(articles sorted by number of sources associating them with KLK3)

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Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence. (PubMed id 2456523)^{1, 2, 3} Schulz P....Fittler F. (1988)
Molecular cloning of human prostate specific antigen cDNA. (PubMed id 2436946)^{1, 2, 3} Lundwall A. and Lilja H. (1987)
Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer. (PubMed id 15893813)^{1, 4, 9} Schatzl G....Gsur A. (2005)
Correlation of prostate-specific antigen promoter polymorphisms with clinicopathological characteristics in breast cancer. (PubMed id 12168876)^{1, 4, 9} Yang Q....Kakudo K. (2002)
Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women. (PubMed id 16365023)^{1, 4, 9} Wang W....Ingles S.A. (2005)
Substrate specificity of prostate-specific antigen (PSA). (PubMed id 9751643)^{1, 2, 9} Coombs G.S.... Corey D.R. (1998)
Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody. (PubMed id 18187150)^{1, 2, 9} Menez R....Stura E.A. (2008)
Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness. (PubMed id 16172228)^{1, 4, 9} Cicek M.S....Witte J.S. (2005)
The impact of polymorphism on prostate specific antigen gene on the risk, tumor volume and pathological stage of prostate cancer. (PubMed id 15017213)^{1, 4, 9} Chiang C.H....Hong C.J. (2004)
Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels. (PubMed id 12865450)^{1, 4, 9} Cramer S.D....Xu J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 354	HGNC: 6364	AceView: KLK3andKLK2	Ensembl:ENSG00000142515	euGenes: HUgn354
ECgene: KLK3	Kegg: 354	H-InvDB: KLK3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KLK3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KLK3	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Prostate_specific_antigen

Intellectual Property for KLK3 gene
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Patent Information for KLK3 gene:
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GeneCards and IP:
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KLK3 Gene

kallikrein-related peptidase 3

Aliases
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KLK3 (Gene Symbol)
Kallikrein-Related Peptidase 3
APS
PSA
P-30 Antigen
Kallikrein 3, (Prostate Specific Antigen)
KLK2A1
Gamma-Seminoprotein
HK3
Kallikrein-3
Prostate Specific Antigen
Prostate-Specific Antigen
Semenogelase
Seminin
EC 3.4.21.77
Gamma-Seminoprotein
Kallikrein-3
Semenogelase
Seminin
EC 3.4.21

recurrent cancer
stable disease
ADENOSIS SCLEROSING
Prostatism
nonmetastatic
Cancer Relapse
Acute prostatitis
prostate cancer stage C
Nocturia
Residual Cancer
Urological Cancer
aggressiveness
Bone Diseases
Breast Cancer
primary tumor
Chronic prostatitis
Adenocarcinoma
refractory cancer
prostate cancer stage A
Carcinoma Transitional Cell
Cancer
disease characteristic
FIBROCYSTIC BREAST DISEASE
Obstruction
premalignant
OBSTRUCTIVE UROPATHY
Urogenital Diseases
Urinary Tract Diseases
local cancer
ANDROGEN DEFICIENCY
MEN 3
BONE LESION
latent cancer prostate
evaluable disease
Gynecomastia
prostate cancer stage B
URINARY TRACT INFECTION ACUTE
Disease regression
cancer recurrence
prostate cancer
Impotence
Tumors
Metastasis
Prostatic Neoplasms
recurrent prostate cancer
prostatic adenocarcinoma
Urethral Stricture
progressive disease
Prostatic Hyperplasia
bladder cancer
measurable disease
Prostatitis granulomatous
Proctitis
Hyperplasia
Intraepithelial Neoplasms
HYPOGONADISM MALE
PROSTATE NODULE
locally advanced cancer
BONE TUMOR
Carcinoma
bilateral cancer
RECTAL BLEEDING
PROSTATE CARCINOMA
METASTATIC CARCINOMA
Erectile Dysfunction
Carcinoma Endometrioid
metastatic cancer
Breast Cysts
regional cancer
Second Malignancy
Prostatitis
Nodular prostate
small cell lung cancer
Prostatic Adenoma
Carcinoma Undifferentiated
prostate cancer stage D
Carcinoma Mucinous
Fowlpox
stage prostate cancer
benign prostatic hyperplasia
Adenocarcinoma Clear Cell
Bleeding
Prostatic Intraepithelial Neoplasia
solid tumor
MICTURITION DISORDER
Carcinoma Intraductal
androgen suppression
Occult Malignancy
WITHDRAWAL SYNDROME
Prostatic Diseases
residual disease
bone metastases
Hypogonadism
adenocarcinoma bladder

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KLK3 Gene

kallikrein-related peptidase 3

Aliasesfor KLK3 gene

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