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KLK3 Gene

protein-coding   GIFtS: 72
GCID: GC19P051358

Kallikrein-Related Peptidase 3

(Previous names: kallikrein 3, (prostate specific antigen))
(Previous symbol: APS)
  See KLK3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 31 2     Prostate-Specific Antigen2
APS1 2 3 5     semenogelase2
PSA2 3 5     seminin2
P-30 Antigen2 3     EC 3.4.21.773
Kallikrein 3, (Prostate Specific Antigen)1     Gamma-seminoprotein3
KLK2A12     Kallikrein-33
gamma-seminoprotein2     Semenogelase3
hK32     Seminin3
kallikrein-32     EC 3.4.218
Prostate Specific Antigen2     

External Ids:    HGNC: 63641   Entrez Gene: 3542   Ensembl: ENSG000001425157   OMIM: 1768205   UniProtKB: P072883   

Export aliases for KLK3 gene to outside databases

Previous GC identifers: GC19P051987 GC19P051719 GC19P056034 GC19P056049 GC19P047693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK3 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Its protein product is a protease present in seminal plasma. It is thought to function normally in the
liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein.
Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of
prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLK3 Gene:
KLK3 (kallikrein-related peptidase 3) is a protein-coding gene. Diseases associated with KLK3 include prostatitis, and nodular prostate. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288
Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Gene Wiki entry for KLK3 (Prostate-specific antigen) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK3 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK3 promoter sequence
   Search Chromatin IP Primers for KLK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.41

KLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051358:  view genomic region     (about GC identifiers)

Start:
51,358,171 bp from pter      End:
51,364,020 bp from pter
Size:
5,850 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288 (See protein sequence)
Recommended Name: Prostate-specific antigen precursor  
Size: 261 amino acids; 28741 Da
Subunit: Forms a heterodimer with SERPINA5
Sequence caution: Sequence=AAD14185.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAA32124.1; Type=Miscellaneous discrepancy;
6 PDB 3D structures from and Proteopedia for KLK3:
1PFA (3D)        2PSA (3D)        2ZCH (3D)        2ZCK (3D)        2ZCL (3D)        3QUM (3D)    
Secondary accessions: C9JXH3 G3V0H4 G3XAE3 Q15096 Q16272 Q86TG8 Q8IXI4
Alternative splicing: 5 isoforms:  P07288-1   P07288-2   P07288-3   P07288-4   P07288-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLK3: NX_P07288

Explore proteomics data for KLK3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn69
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KLK3 (P07288) (see all 9)
     CGGVLVH  SGGPLVC  GVLQGIT  GDSGGPL 


    See KLK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001025218.1  NP_001025219.1  NP_001639.1  

    ENSEMBL proteins: 
     ENSP00000472213   ENSP00000471648   ENSP00000314151   ENSP00000393628   ENSP00000470523  
     ENSP00000472411   ENSP00000472907   ENSP00000468912   ENSP00000471155   ENSP00000353829  
     ENSP00000471827  
    Reactome Protein details: P07288

    KLK3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant KLK3 Protein
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    Novus Biologicals KLK3 Proteins
    Novus Biologicals KLK3 Lysates
    Sino Biological Recombinant Protein for KLK3
    Sino Biological Cell Lysate for KLK3
    ProSpec Recombinant Protein for KLK3
    Cloud-Clone Corp. Proteins for KLK3

     
    Search eBioscience for Proteins for KLK3 

    KLK3 Antibody Products:

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    KLK3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLK3
    Cloud-Clone Corp. CLIAs for KLK3
    Search eBioscience for ELISAs for KLK3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P07288

    ProtoNet protein and cluster: P07288

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with KLK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK3_HUMAN, P07288
    Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum
    Catalytic activity: Preferential cleavage: -Tyr- -Xaa-
    Enzyme regulation: Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen
    than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders

         Genatlas biochemistry entry for KLK3:
    kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast carcinomas

         Enzyme Numbers (IUBMB): EC 3.4.21.771 EC 3.4.212

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI1725227
    GO:0008236serine-type peptidase activity TAS2470553
         
    Find genes that share ontologies with KLK3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLK3:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK3

    miRNA
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    miRTarBase miRNAs that target KLK3:
    hsa-mir-335-5p (MIRT017222)

    Block miRNA regulation of human, mouse, rat KLK3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KLK3:
    hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidKLK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLK3
    Predesigned siRNA for gene silencing in human, mouse, rat KLK3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): KLK3 (NM_001648)
    Sino Biological Human cDNA Clone for KLK3
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10381 VA4-12887 VA6-13505) for KLK3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK3_HUMAN, P07288: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with KLK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK3 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2Transcription Androgen Receptor nuclear signaling
    Transcription Androgen Receptor nuclear signaling0.49
    3Glioma
    Prostate cancer0.39
    4Prostate Cancer
    Prostate Cancer0.32
    5Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31


    Find genes that share SuperPaths with KLK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK3
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 Cell Signaling Technology (CST) Pathways for KLK3
        Adhesion
    Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for KLK3
        Transcription Androgen Receptor nuclear signaling
    Cell adhesion ECM remodeling

    5 BioSystems Pathways for KLK3
        Androgen receptor signaling pathway
    Prostate Cancer
    Regulation of Androgen receptor activity
    FOXA1 transcription factor network
    Coregulation of Androgen receptor activity


    1 Reactome Pathway for KLK3
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


    2 Kegg Pathways  (Kegg details for KLK3):
        Pathways in cancer
    Prostate cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLK3: 
              Estrogen Receptor Signaling in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for KLK3 (P072883 ENSP000003141514) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINA1P010093, ENSP000003480684I2D: score=3 STRING: ENSP00000348068
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    SERPINA5P051543, ENSP000003332034I2D: score=2 STRING: ENSP00000333203
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0016525negative regulation of angiogenesis NAS10675891
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with KLK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK3

    Selected Novoseek inferred chemical compound relationships for KLK3 gene (see all 123)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estramustine 89.2 63 17942366 (4), 10076535 (3), 10687988 (3), 16729913 (2) (see all 39)
    bicalutamide 87.7 158 9112515 (6), 7513530 (5), 15134983 (3), 19902465 (3) (see all 70)
    testosterone 86.5 2207 18843272 (11), 11421528 (9), 12539223 (9), 7541588 (7) (see all 99)
    estramustine phosphate 83.9 49 18634439 (5), 16882080 (5), 16037707 (4), 7542158 (3) (see all 19)
    cpsa 83.3 257 11834399 (6), 10736503 (5), 10759671 (4), 12384160 (4) (see all 52)
    flutamide 83.1 186 11706524 (7), 8558675 (7), 9112515 (6), 10705202 (6) (see all 71)
    finasteride 80.7 389 9426721 (10), 9586598 (9), 9218012 (9), 9649261 (8) (see all 99)
    pt-2a 80.7 12 15073852 (4), 11176395 (1), 15711264 (1), 10569562 (1) (see all 7)
    docetaxel 79.8 226 19575420 (6), 18487550 (4), 18990177 (4), 19920389 (4) (see all 99)
    prostascint 78.9 28 10617872 (3), 11920467 (2), 11113745 (2), 10850293 (2) (see all 15)



    Find genes that share compounds with KLK3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLK3 gene (5 alternative transcripts): 
    NM_001030047.1  NM_001030048.1  NM_001648.2  NM_001030049.1  NM_001030050.1  

    Unigene Cluster for KLK3:

    Kallikrein-related peptidase 3
    Hs.171995  [show with all ESTs]
    Unigene Representative Sequence: AF335478
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601503 ENST00000596185 ENST00000326003(uc021uyi.1 uc010eof.1)
    ENST00000422986(uc002ptr.1) ENST00000601349 ENST00000595151 ENST00000597286
    ENST00000596333 ENST00000597483 ENST00000593997 ENST00000595392 ENST00000595952
    ENST00000360617(uc002pts.1) ENST00000598145 ENST00000601812
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate KLK3:
    hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidKLK3 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK3
    Primer
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    Additional mRNA sequence: 

    AF335477.1 AF335478.1 AJ310937.1 AJ310938.1 AJ459782.1 AJ459783.1 AJ459784.1 AJ512346.1 
    AK311887.1 AK312933.1 BC005307.1 BC050595.2 BC056665.1 BT019862.1 DQ641251.1 M21895.1 
    M21896.1 M21897.1 M26663.1 S75755.1 U17040.1 X05332.1 X07730.1 X75682.1 

    Selected DOTS entries (see all 57):

    DT.92412919  DT.92461817  DT.101987510  DT.95208239  DT.455621  DT.87016872  DT.92029956  DT.92461821 
    DT.100060506  DT.87016874  DT.95208245  DT.95208246  DT.95208227  DT.87002147  DT.92367459  DT.87079599 
    DT.121490621  DT.95208221  DT.455618  DT.121490734  DT.100735196  DT.206121  DT.91966580  DT.100643341 

    Selected AceView cDNA sequences (see all 1035):

    BQ276292 AI659871 BF477328 BF477225 BF588664 BF588853 CA454512 BX504463 
    CA488291 CF140189 BF475406 CF135025 BF477018 AA658347 NM_001002232 CF141000 
    CR589977 BF588898 CA454428 CF139149 AA595465 AA532387 T29518 BF476973 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLK3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                                -     -     -                             -                       -     -                                       
    SP2:                                      -     -                             -                       -     -                                       
    SP3:                                -     -     -                 -           -                       -                                             
    SP4:                                -     -     -                 -           -                       -     -                                       
    SP5:                                -     -     -                             -                       -                                             


    ECgene alternative splicing isoforms for KLK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGGGGAT
    KLK3 Expression
    About this image


    KLK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Testis (Reproductive System)
     
     Prostate (Endocrine System)
    KLK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171995
        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLK3: 
              Estrogen Receptor Signaling in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Prostate Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLK3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk1b275
    Klk1b221
    kallikrein 1-related peptidase b275
    kallikrein 1-related peptidase b221
    65.49(n)1
    56.86(a)1
      7 (28.54 cM)5
    136461  NM_010114.11  NP_034244.11 
     440522905 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    1 → many
    GL343514.1(217681-240007)


    ENSEMBL Gene Tree for KLK3 (if available)
    TreeFam Gene Tree for KLK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK3 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  
    PRSS582  PRSS32  KLK82  
    Selected SIMAP similar genes for KLK3 using alignment to 10 protein entries:     KLK3_HUMAN (see all proteins) (see all similar genes):
    APS    KLK2    KLK1    KLK4    KLK7    KLK8
    KLK9    KLK6    KLK11    KLK13    TMPRSS12    KLK5
    DKFZp586F0824    TMPRSS6    PRSS1    AZU1    CMA1    GZMK

    Find genes that share paralogs with KLK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK3 (see all 348)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458572521,2
    C--47697511(+) TGGCT-/CAGGTG
    TCCAGAGG
    CTGCC
    3 -- int10--------
    rs2015057751,2
    C--47697513(+) CTCAG-/CCGTGTC 3 -- int10--------
    rs716704931,2
    C--47697514(+) TCAGG-/C/CC  
            
    TGTCC
    3 -- int10--------
    rs716810861,2
    C--47697517(+) AGGTG-/TCCAGA 3 -- int10--------
    rs339781971,2
    C--51356238(+) TTTTTT/-TTTTT 3 -- us2k11Minor allele frequency- -:0.50NA 2
    rs27394501,2
    C,F--51357087(+) GCACAC/TGGCAC 3 -- us2k18Minor allele frequency- T:0.45NA CSA WA EA 367
    rs175549581,2
    C,F--51357965(+) GCTAC-/AAGGGC 3 -- us2k12Minor allele frequency- A:0.26NA MN 136
    rs1406274001,2
    --51538043(+) TCACTC/TAACTA 3 -- us2k10--------
    rs3722114061,2
    C--51538073(+) TCAAA-/TTCTTTTT 3 -- us2k10--------
    rs2668601,2
    C--51538130(+) ggagtA/Gcagtg 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLK3 (51358171 - 51364020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524465CNV Loss19592680
    nsv2531CNV Loss18451855

    Human Gene Mutation Database (HGMD): KLK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK3
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176820    OMIM disorders: --

    Selected diseases for KLK3 (see all 22):    
    About MalaCards
    prostatitis    nodular prostate    urethral stricture    breast disease
    nephrogenic adenoma of the urethra    prostatic adenoma    penile disease    fletcher factor deficiency
    hansen's disease    lymphocele    nephrogenic adenoma    androgenic alopecia
    impotence    prostatic hypertrophy    bladder disease    inflammatory breast carcinoma
    neurogenic bladder    female breast carcinoma    withdrawal disorder    villous adenoma

    16 diseases from the University of Copenhagen DISEASES database for KLK3:
    Prostate cancer     Carcinoma     Prostatitis     Prostatic hypertrophy
    Urethral stricture     Sexual dysfunction     Penile disease     Proctitis
    Prostatic adenoma     Neutropenia     Gynecomastia     Urinary bladder cancer
    Lymphocele     Withdrawal disorder     Breast cancer     Hypogonadism

    Find genes that share disorders with KLK3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KLK3 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 98.8 14595 9372881 (10), 11391681 (9), 12187207 (9), 7537603 (9) (see all 99)
    prostate carcinoma 94.2 1143 10951348 (6), 16419068 (6), 8847816 (5), 15578715 (5) (see all 99)
    benign prostatic hyperplasia 93.6 1011 9674713 (6), 8791046 (4), 15044396 (4), 7516808 (3) (see all 99)
    prostatic adenocarcinoma 91.5 266 7525979 (5), 17963516 (3), 8958315 (2), 11106075 (2) (see all 99)
    recurrent prostate cancer 89.2 69 9126236 (2), 9338734 (2), 16609031 (2), 1279216 (1) (see all 49)
    prostatic diseases 88.9 229 7551887 (3), 11720279 (3), 12394676 (3), 7685140 (3) (see all 99)
    prostatic intraepithelial neoplasia 88.6 187 10524873 (8), 7686984 (7), 8709305 (4), 7541850 (3) (see all 81)
    androgen suppression 87.7 91 9166947 (4), 10477903 (4), 14712491 (3), 11685725 (2) (see all 49)
    cancer 87.1 3881 7514689 (8), 11743285 (7), 1283897 (7), 9145718 (7) (see all 99)
    stage prostate cancer 86.3 61 11999465 (2), 18411775 (2), 9649289 (2), 14675918 (1) (see all 44)

    Genetic Association Database (GAD): KLK3
    Human Genome Epidemiology (HuGE) Navigator: KLK3 (144 documents)

    Export disorders for KLK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK3 gene, integrated from 10 sources (see all 3747):
    (articles sorted by number of sources associating them with KLK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence. (PubMed id 2456523)1, 2, 3 Schulz P....Fittler F. (Nucleic Acids Res. 1988)
    2. Molecular cloning of human prostate specific antigen cDNA. (PubMed id 2436946)1, 2, 3 Lundwall A. and Lilja H. (FEBS Lett. 1987)
    3. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4, 9 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    4. Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer. (PubMed id 18768516)1, 4, 9 Cramer S.D....Peehl D.M. (amp 2008)
    5. Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer. (PubMed id 15893813)1, 4, 9 Schatzl G....Gsur A. (Urology 2005)
    6. Shorter CAG repeats in androgen receptor and non-GG genotypes in prostate-specific antigen loci are associated with decreased risk of benign prostatic hyperplasia and prostate cancer. (PubMed id 18495332)1, 4, 9 Das K....Lau W. (Cancer Lett. 2008)
    7. Is there an inter-relationship between prostate specific antigen, kallikrein-2 and androgen receptor gene polymorphisms with risk of prostate cancer in north Indian population? (PubMed id 17257635)1, 4, 9 Mittal R.D....Mandhani A. (Steroids 2007)
    8. Correlation of prostate-specific antigen promoter polymorphisms with clinicopathological characteristics in breast cancer. (PubMed id 12168876)1, 4, 9 Yang Q....Kakudo K. (Anticancer Res. 2002)
    9. A G/A polymorphism in the androgen response element 1 of prostate-specific antigen gene correlates with the response to androgen deprivation therapy in Japanese population. (PubMed id 17094454)1, 4, 9 Shibahara T....Sugimura Y. (Anticancer Res. 2006)
    10. Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women. (PubMed id 16365023)1, 4, 9 Wang W....Ingles S.A. (amp 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 354 HGNC: 6364 AceView: KLK3andKLK2 Ensembl:ENSG00000142515 euGenes: HUgn354
    ECgene: KLK3 Kegg: 354 H-InvDB: KLK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Prostate_specific_antigen

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK3 gene:
    Search GeneIP for patents involving KLK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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