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KLK3 Gene

protein-coding GIFtS: 66

GC19P056049

kallikrein-related peptidase 3
(Previous names: kallikrein 3, (prostate specific antigen) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: APS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
APS ^², ³, ⁵
EC 3.4.21.77 ^³
Gamma-seminoprotein ^³
KLK2A1 ^²
Kallikrein-3 ^³
PSA ^¹, ², ³, ⁵
Semenogelase ^³
Seminin ^³
gamma-seminoprotein ^²
hK3 ^²
semenogelase ^²
seminin ^²

Descriptions
P-30 antigen ^², ³
kallikrein 3, (prostate specific antigen) ^¹
kallikrein-related peptidase 3 ^²
prostate specific antigen ^²

External Ids
HGNC: 6364¹
Entrez Gene: 354²
UniProtKB: P07288³
Ensembl: ENSG00000142515⁷

Search outside databases for aliases for KLK3 gene

Previous GC identifers: GC19P051987 GC19P051719 GC19P056034

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KLK3:

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing

evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential

as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily

members located in a cluster on chromosome 19. Its protein product is a protease present in

seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum,

presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this

protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of

prostatic carcinoma. Alternate splicing of this gene generates several transcript variants

encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Gene Wiki entry for KLK3 (Prostate_specific_antigen)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KLK3 gene

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.41

KLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P056049: (about GC identifiers)

Start:	56,049,983 bp from pter
End:	56,055,832 bp from pter
Size:	5,850 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288 (See protein sequence)

Recommended Name: Prostate-specific antigen precursor

Size: 261 amino acids; 28741 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1PFA (3D)

2PSA (3D)

2ZCH (3D)

2ZCK (3D)

2ZCL (3D)

Secondary accessions: Q16272 Q86TG8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001025218.1 NP_001025219.1 NP_001025220.1 NP_001025221.1 NP_001639.1

ENSEMBL proteins:

ENSP00000314151 ENSP00000314459 ENSP00000353829

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant KLK3 Protein
	Sigma-Aldrich Proteins for KLK3
	R&D Systems Recombinant & Natural Proteins for KLK3 (Kallikrein 3/PSA)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Prostate Specific Antigen)
	Human Recombinant Proteins from Abnova (KLK3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for KLK3:

	Invitrogen Antibodies for KLK3
	Millipore Mono- and Polyclonal Antibodies for the study of KLK3
	Sigma-Aldrich Antibodies for KLK3
	R&D Systems Antibodies for KLK3 (Kallikrein 3/PSA)
	Antibodies from Abcam (Prostate Specific Antigen), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KLK3)
	Novus Biologicals Antibodies for KLK3

Assays for KLK3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for KLK3 (Kallikrein 3/PSA) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P07288

ProtoNet protein and cluster: P07288

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily

Similarity: Contains 1 peptidase S1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KLK3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KLK3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_145864

Applied Biosystems Silencer® siRNAs for KLK3

Sigma-Aldrich siRNA and siRNA Panels for KLK3

Sigma-Aldrich shRNA for KLK3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KLK3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001030047
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001030047
untagged cDNA clones in CMV expression vector (see all 7): NM_001030047

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001648

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Catalytic activity: Preferential cleavage: -Tyr- -Xaa-

Enzyme Number (IUBMB): EC 3.4.21.77

Genatlas biochemistry entry for KLK3:

kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast

carcinomas

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for KLK3 (Your Favorite Gene powered by Ingenuity)

Prostate Cancer Signaling

GeneDecks KLK3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for KLK3

5/133 Interacting proteins for KLK3 (ENSP00000314151³) via UniProtKB, MINT, and/or STRING (see all 133 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	ENSP00000363822³	STRING (score=.996)
SERPINA5	ENSP00000333203³	STRING (score=.988)
IGF1	ENSP00000302665³	STRING (score=.984)
CDK6	ENSP00000265734³	STRING (score=.983)
LATS2	ENSP00000372035³	STRING (score=.978)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0016525	negative regulation of angiogenesis	NAS	10675891

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KLK3

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KLK3
10/21 Novoseek chemical compound relationships for KLK3 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pt-2a	78.93	12	15073852 (4), 11176395 (1), 15711264 (1), 10569562 (1) (see all 7)
provenge	69.02	3	15992463 (1), 16736512 (1), 17084174 (1)
125i	62.47	26	7543606 (2), 11516848 (2), 14751360 (2), 10030621 (2) (see all 12)
psms	58.18	6	17572201 (1), 11489708 (1), 18674807 (1)
r1881	56.52	9	18591159 (3), 18676361 (2), 18621129 (1)
blp 25	53.59	4	16753376 (3)
methylseleninic acid	48.13	17	15141018 (4), 16020662 (3), 17120196 (1), 17346688 (1) (see all 6)
mibolerone	47.61	3	1712248 (3)
iridium	41.13	5	9403047 (1), 11712084 (1), 11442673 (1), 16643612 (1) (see all 5)
3-alpha-androstanediol glucuronide	40.94	14	9062481 (2), 11297583 (1), 10634368 (1), 8259343 (1) (see all 5)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KLK3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KLK3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_145864

Sigma-Aldrich siRNA and siRNA Panels for KLK3

Sigma-Aldrich shRNA for KLK3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001030047 NM_001030048 NM_001030049 NM_001030050 NM_001648

REFSEQ mRNAs for KLK3 gene (5 alternative transcripts):

NM_001030047.1 NM_001030048.1 NM_001030049.1 NM_001030050.1 NM_001648.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001030047 NM_001030048 NM_001030049 NM_001030050 NM_001648

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001030047
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001030047
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_001030047

Additional cDNA sequence:

AF335477.1 AF335478.1 AJ310937.1 AJ310938.1 AJ459782.1 AJ459783.1 AJ459784.1 AJ512346.1

AK311887.1 AK312933.1 BC005307.1 BC050595.2 BC056665.1 BT019862.1 DQ641251.1 M21895.1

M21896.1 M21897.1 M26663.1 S75755.1 U17040.1 X05332.1 X07730.1 X75682.1

24/54 DOTS entries (see all 54 ):

DT.92412919 DT.92461817 DT.101987510 DT.95208239 DT.455621 DT.87016872 DT.92029956 DT.92461821

DT.100060506 DT.87016874 DT.95208245 DT.95208246 DT.95208227 DT.92367459 DT.87002147 DT.87079599

DT.121490621 DT.95208221 DT.455618 DT.121490734 DT.100735196 DT.206121 DT.91966580 DT.100643341

24/1035 AceView cDNA sequences (see all 1035 ):

CA488291 CA976022 AA595357 CF146776 BX504463 BX508845 BF588642 CA495379

AI989309 BF588664 BQ276292 BF477018 NM_005551 NM_001002231 CF141000 BF476973

CF139149 NM_145864 BF477261 BF592190 CA487655 AA595465 CA487643 T29518

highest scoring ESTs for KLK3:

X05332 AA177118 AA216409 AA224955 AA224994 AA225043 AA225114 AA225137 AA225508 AA226222

Unigene Cluster for KLK3:

Kallikrein-related peptidase 3

Hs.171995 [show with all ESTs]

Unigene Representative Sequence: AF335478

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KLK3 (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f
SP1:											-		-		-										-								-		-
SP2:													-		-										-								-		-
SP3:											-		-		-						-				-								-
SP4:											-		-		-						-				-								-		-
SP5:											-		-		-										-								-

About this scheme

ECgene alternative splicing isoforms for KLK3

3 Ensembl transcripts including schematic representations:

ENST00000326003 ENST00000326052 ENST00000360617

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KLK3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KLK3

¹ / ² / ³

14 probe-sets matching KLK3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40794_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.88	X05332	1.00	1.00	1.00	1
1805_g_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.84	X07730	0.80	1.00	0.91	1
1661_i_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.08	HG2261-HT2351	0.20	1.00	0.72	1
1804_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.36	X07730	0.80	1.00	0.91	1
1662_r_at²^{, 3}	U95-A	1	1.00	1.00	0.82	1.29	HG2261-HT2351	0.20	1.00	0.72	1
1514_g_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.73	HG2261-HT2352	0.20	1.00	0.72	1
76108_at²^{, 3}	U95-E	2	1.00	0.97	0.57	1.32	AA225045	0.60	1.00	0.82	1
1513_at²^{, 3}	U95-A	2	1.00	0.78	0.88	0.77	HG2261-HT2352	0.20	1.00	0.72	1
69598_at*²^{, 3}	U95-E	1	--	--	0.88	0.64	AI669704	0.40	1.00	0.76	1
89468_at*²^{, 3}	U95-E	1	--	--	-0.23	1.59	AA614254	0.20	1.00	0.72	1
204582_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001648	0.60	1.00	0.82	1
204583_x_at²^{, 3}	U133-A	2	1.00	0.91	--	--	U17040	0.80	1.00	0.91	1
204582_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204583_x_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks KLK3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GGATGGGGAT

SOURCE GeneReport for Unigene cluster: Hs.171995
Expression variation in blood from EXPOLDB for KLK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for KLK3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for KLK3 gene

TRYX3² KLK2² KLK10² KLK1² LOC136242²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/128 NCBI SNPs in KLK3 are shown (see all 128 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 86)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2003783^1,2	A,C,F,H	56053284(-)	`CGTGAG/TCTCGG`	4	L/I	mis¹ int¹ ese³		14	MN EU EA WA NA	2724
	rs3760722^1,2	A,C,F,H	56049628(+)	`GGTGTC/TTTAGG`	5	--	ng5¹		7	EA MN EU WA	2306
	rs1061476^1,2	A,C,F,H	56051899(+)	`ACTGAG/ACACAC`	5	--	ng3¹ int¹		9	MN EU EA WA	974
	rs1061477^1,2	A,C,F,H	56051908(+)	`ACGCAC/TGGGAT`	5	--	int¹ ng3¹		9	MN EU EA WA	1002
	rs2569735^1,2	A,C,F,H	56056081(+)	`catggG/Agtact`	4	--	ng3¹		8	EU EA WA	830
--	rs2739451^1,2	A,C,F,H	56049083(+)	`gtttcT/Cctggt`	5	--	ng5¹		12	EU EA WA	1256
	rs8104556^1,2	A,C,F,H	56056192(+)	`tgaatC/Tgcact`	4	--	ng3¹		3	EU EA	298
--	rs2659122^1,2	A,C,F,H	56054838(-)	`CCGGTA/GGGGAA`	4	--	int¹ ut3¹ ese³ trp³		9	EA EU WA	2296
	rs2271092^1,2	C,F,H	56051355(-)	`CTTCTC/TGCACT`	5	E/K	mis¹ ese³		5	EA EU WA	1892
	rs6998^1,2	C,F,H	56055473(+)	`GTGGGG/ATACAG`	4	--	ut3¹ ese³		16	MN EU EA WA NA	1782

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HapMap Linkage Disequilibrium images for KLK3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176820

10/94 Novoseek disease relationships for KLK3 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	98.70	13436	9372881 (10), 11391681 (9), 12187207 (9), 7537603 (9) (see all 99)
prostate carcinoma	94.29	1117	10951348 (6), 16419068 (6), 8847816 (5), 15578715 (5) (see all 99)
benign prostatic hyperplasia	93.42	969	9674713 (6), 8791046 (4), 15044396 (4), 7516808 (3) (see all 99)
prostatic adenocarcinoma	91.20	247	7525979 (5), 17963516 (3), 8958315 (2), 11106075 (2) (see all 99)
prostatic diseases	88.95	218	7551887 (3), 11720279 (3), 12394676 (3), 7685140 (3) (see all 99)
recurrent prostate cancer	88.52	61	9126236 (2), 9338734 (2), 16609031 (2), 1279216 (1) (see all 44)
prostatic intraepithelial neoplasia	88.04	161	10524873 (8), 7686984 (7), 8709305 (4), 7541850 (3) (see all 72)
cancer	86.81	3627	7514689 (8), 11743285 (7), 1283897 (7), 9145718 (7) (see all 99)
androgen suppression	86.67	83	9166947 (4), 10477903 (4), 14712491 (3), 11685725 (2) (see all 45)
stage prostate cancer	86.17	54	11999465 (2), 18411775 (2), 9649289 (2), 14675918 (1) (see all 41)

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Human Gene Mutation Database: KLK3
Genetic Association Database: KLK3
Human Genome Epidemiology Navigator: KLK3 (96 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/2709 PubMed articles for KLK3 gene (see all 2709 ):

Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence. (PubMed id 2456523)^{2, 3, 4} Schulz P....Fittler F. (1988)
Molecular cloning of human prostate specific antigen cDNA. (PubMed id 2436946)^{2, 3, 4} Lundwall A. and Lilja H. (1987)
Polymorphic CAG repeats in the androgen receptor gene, prostate-specific antigen polymorphism and prostate cancer risk. (PubMed id 12376473)^{1, 3, 6} Gsur A....Micksche M. (2002)
Correlation of prostate-specific antigen promoter polymorphisms with clinicopathological characteristics in breast cancer. (PubMed id 12168876)^{1, 3, 6} Yang Q....Kakudo K. (2002)
Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women. (PubMed id 16365023)^{1, 3, 6} Wang W....Ingles S.A. (2005)
Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors. (PubMed id 7527295)^{1, 3, 4} Monne M.... Diamandis E.P. (1994)
Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness. (PubMed id 16172228)^{1, 3, 6} Cicek M.S....Witte J.S. (2005)
Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels. (PubMed id 12865450)^{1, 3, 6} Cramer S.D....Xu J. (2003)
Novel polymorphisms in prostate specific antigen gene and its association with prostate cancer. (PubMed id 11299734)^{1, 3, 6} Yang Q....Kakudo K. (2001)
Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)^{1, 3, 4} Gan L.... Wang K. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 354	HGNC: 6364	AceView: KLK3andKLK2	Ensembl:ENSG00000142515	euGenes: HUgn354
ECgene: KLK3	H-InvDB: KLK3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for KLK3	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Prostate_specific_antigen

Licensable Technologies for KLK3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KLK3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KLK3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KLK3		Antibodies for KLK3
	Explore super-pooled esiRNAs		Proteins for KLK3
	Lentivirus-delivered shRNAs for KLK3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KLK3)
	Antibodies (KLK3)
	Chimera RNAi (KLK3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Prostate Specific Antigen)
	Antibodies (Prostate Specific Antigen)

Search OriGene for KLK3

Search Tocris compounds for KLK3

	Drugs for KLK3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KLK3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KLK3 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

KLK3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for KLK3

Summaries
for KLK3

Genomic Location
for KLK3

Proteins
for KLK3

Protein Domains/
Families
for KLK3

Gene Function
for KLK3

Pathways & Interactions
for KLK3

Drugs & Compounds
for KLK3

Transcripts
for KLK3

Expression
for KLK3

Orthologs
for KLK3

Paralogs
for KLK3

SNPs/Variants
for KLK3

Disorders & Mutations
for KLK3

Medical News
for KLK3

Publications
for KLK3

Search for KLK3

Genome Databases showing KLK3

Other Databases showing KLK3

Specialized Databases showing KLK3

Licensable Technologies
for KLK3

Services
for KLK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KLK3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor KLK3

Summariesfor KLK3

Genomic Locationfor KLK3

Proteinsfor KLK3

Protein Domains/Familiesfor KLK3

Gene Functionfor KLK3

Pathways & Interactionsfor KLK3

Drugs & Compoundsfor KLK3

Transcriptsfor KLK3

Expression for KLK3

Orthologsfor KLK3

Paralogsfor KLK3

SNPs/Variantsfor KLK3

Disorders & Mutationsfor KLK3

Medical Newsfor KLK3

Publicationsfor KLK3

Search for KLK3

Genome Databases showing KLK3

Other Databases showing KLK3

Specialized Databases showing KLK3

Licensable Technologiesfor KLK3

Servicesfor KLK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KLK3

Summaries
for KLK3

Genomic Location
for KLK3

Proteins
for KLK3

Protein Domains/
Families
for KLK3

Gene Function
for KLK3

Pathways & Interactions
for KLK3

Drugs & Compounds
for KLK3

Transcripts
for KLK3

Expression
for KLK3

Orthologs
for KLK3

Paralogs
for KLK3

SNPs/Variants
for KLK3

Disorders & Mutations
for KLK3

Medical News
for KLK3

Publications
for KLK3

Licensable Technologies
for KLK3

Services
for KLK3