KLK2 Gene
protein-coding GIFtS: 68
GCID: GC19P051376
|
|
kallikrein-related peptidase 2(Previous names: kallikrein 2, prostatic )
| |
Aliases
for KLK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kallikrein-Related Peptidase 21 2 | | Glandular Kallikrein 22 | | Kallikrein 2, Prostatic1 2 | | HK21 | | Glandular Kallikrein-12 3 | | Kallikrein-21 | | Tissue Kallikrein-22 3 | | EC 3.4.21.353 | | HGK-11 | | EC 3.4.218 | | KLK2A22 | | |
Export aliases for KLK2 gene to outside databasesPrevious GC identifers: GC19P052005 GC19P051737 GC19P056052 GC19P056068 GC19P047711 |
Summaries
for KLK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLK2:
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteasesthat are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions.The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginineresidues. This protein is primarily expressed in prostatic tissue and is responsible for cleavingpro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumorcells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-codingtranscript variants. (provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin
Gene Wiki entry for KLK2
|
Genomic Views
for KLK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLK2 gene promoter:
NF-kappaB1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33KLK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P051376: view genomic region
(about GC identifiers)
Start:
|
51,376,689 bp from pter |
End:
|
51,383,823 bp from pter |
Size:
|
7,135 bases |
Orientation:
|
plus strand |
|
Proteins
for KLK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151 (See
protein sequence)Recommended Name: Kallikrein-2 precursor Size: 261 amino acids; 28671 Da
Sequence caution: Sequence=AAD13817.1; Type=Miscellaneous discrepancy;
Secondary accessions: B4DU93 B4DUB0 F5H8L3 Q15946 Q9UJZ9Alternative splicing: 4 isoforms: P20151-1 P20151-2 P20151-3 P20151-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KLK2: NX_P20151
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P20151
4/10 DME Specific Peptides for KLK2 (P20151) (see all 10)
KLK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001002231.1 NP_001243009.1 NP_005542.1
ENSEMBL proteins: ENSP00000313581 ENSP00000350748 ENSP00000375686 Reactome Protein details: P20151
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
KLK2 for ontologies About GeneDecksing
KLK2 Antibody Products:
Assay Products for KLK2: |
Protein
Domains /
Families
for KLK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLK2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P20151ProtoNet protein and cluster: P20151 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151Similarity: Belongs to the peptidase S1 family. Kallikrein subfamilySimilarity: Contains 1 peptidase S1 domain |
Function
for KLK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykininCatalytic activity: Preferential cleavage of Arg- -Xaa bonds in small molecule substrates. Highly selective action torelease kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met- -Xaa or Leu- -Xaa Genatlas biochemistry entry for KLK2:kallikrein 2,glandular,expressed in the prostate,complexing with protease inhibitor 6 in prostate cancer tissue
Enzyme Numbers (IUBMB): EC 3.4.21.351 EC 3.4.212
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): KLK2 (NM_001002231) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IDA | 9042371 |
KLK2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KLK2:
|
Pathways & Interactions
for KLK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Degradation of the extracellular matrix | | | 2 | Blood Coagulation Cascade | | | 3 | Cell adhesion_ECM remodeling | | | 4 | Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | | | 5 | Activation of proMMP8 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KLK2
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK2
1  GeneGo (Thomson Reuters) Pathway for KLK2
2  BioSystems Pathways for KLK2
5/6 
Reactome Pathways for KLK2 (see all 6)
1 
Kegg Pathway (Kegg details for KLK2):
KLK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/21 Interacting proteins for KLK2 (P201513 ENSP000003135814) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0022617 | extracellular matrix disassembly |
TAS | -- | | GO:0030198 | extracellular matrix organization |
TAS | -- |
KLK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KLK2 for compounds About GeneDecksing
 Browse Tocris compounds for KLK2
2 HMDB Compounds for KLK2 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Somatostatin | Growth hormone release inhibiting factor;Somatostatin-14;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys | -- | -- | | Somatostatin fragment 3-14 | Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys [Disulfide bridge: 3-14] | -- | -- |
6 Novoseek chemical compound relationships for KLK2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| serine |
63.9 |
14 |
10438493 (1), 10583401 (1), 20128684 (1), 10024471 (1) (see all 11) |
| progestins |
50 |
2 |
9205072 (1) |
| dihydrotestosterone |
46.5 |
2 |
1370633 (1), 20043108 (1) |
| testosterone |
41.8 |
24 |
10197620 (4), 9241247 (3), 12767274 (2), 1370633 (1) (see all 8) |
| steroid |
14.8 |
3 |
11948967 (1), 19147544 (1), 9205072 (1) |
| oligonucleotide |
12.3 |
3 |
7515392 (1), 1691151 (1) |
Search CenterWatch for drugs/clinical trials and news about KLK2
|
Transcripts
for KLK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLK2 gene (4 alternative transcripts): NM_001002231.2 NM_001256080.1 NM_005551.4 NM_001002232.2 Unigene Cluster for KLK2: Kallikrein-related peptidase 2 Hs.515560 [show with all ESTs]Unigene Representative Sequence: NR_0457633 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000325321(uc002ptv.3 uc010ycl.2 uc010ycm.2) ENST00000358049(uc010eog.3 uc010yck.2 uc002ptu.3 uc002ptt.3)
ENST00000391810
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KLK2 (NM_001002231) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK2 |
Additional cDNA sequence: AF188745.1 AF188746.1 AF188747.1 AK300527.1 AK300549.1 AK300566.1 AK309968.1 AK309969.1 AK309973.1 AK309982.1 AK309985.1 AK315890.1 AY429509.1 AY429510.1 BC005196.1 BT006650.1 NR_045762.1 NR_045763.1 S39329.1 24/34 DOTS entries (see all 34): DT.121490814 DT.121490591 DT.422516 DT.101963585 DT.85101208 DT.87046802 DT.95359387 DT.121490632 DT.121490749 DT.85104723 DT.91756917 DT.100689427 DT.91966580 DT.91756926 DT.101986345 DT.121490688 DT.75147406 DT.91858807 DT.92416838 DT.95264855 DT.95264857 DT.97838927 DT.85104722 DT.99973681 24/1035 AceView cDNA sequences (see all 1035): CA454428 AA595357 AI201973 BF588771 CA454512 BF475406 CF140189 CF146776 AA588496 CF135025 BF588767 CF134901 CD612337 CA489848 BF063885 BF063868 BF063853 BF477021 BX508845 NM_001648 BF592190 BF588838 BF588659 S75755
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for KLK2 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | - | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11b | · | 11c | · | 11d |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for KLK2
|
Expression
for KLK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGGTTAA
About this image
See KLK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLK2
SOURCE GeneReport for Unigene cluster: Hs.515560
SABiosciences Custom PCR Arrays for KLK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KLK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK2 |
Orthologs
for KLK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLK2 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for KLK2 (if available)
TreeFam Gene Tree for KLK2 (if available) |
Paralogs
for KLK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLK2 gene
- KLK102 KLK12 KLK42 PRSS372 KLK112 KLK72 KLK142 KLK92
- KLK122 KLK132 KLK62 KLK152 KLK52 PRSS12 PRSS582 PRSS32
- KLK32 KLK82
18/79 SIMAP similar genes for KLK2 using alignment to 8 protein entries: KLK2_HUMAN (see all proteins)
(see all similar genes):APS KLK3 KLK1 KLK8 KLK6 KLK7
KLK9 KLK11 KLK5 KLK4 CTRB1 KLK14
TRY6 TRY8 PRSS3 KLK13 CTRB2 GZMK
KLK2 for paralogs About GeneDecksing
|
Genomic Variants
for KLK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLK2 (51376689 - 51383823 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLK2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK2 |
|
Disorders
/ Diseases
for KLK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLK2 for disorders About GeneDecksing
OMIM gene information: 147960
OMIM disorders: --
14  diseases for KLK2: About MalaCardsprostatitis prostate cancer renal cell carcinoma prostate cancer, progression of
prostate carcinoma prostate disease breast cancer ovarian carcinoma
infertility carcinoma meningioma adenocarcinoma
hypertension leukemia
1 disease from the University of Copenhagen DISEASES database for KLK2:Prostate cancer 9 Novoseek disease relationships for KLK2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostate cancer |
78.2 |
93 |
17085659 (6), 16322300 (3), 8950360 (3), 11967950 (3) (see all 41) |
| benign prostatic hyperplasia |
61.3 |
6 |
1370633 (1), 10583401 (1), 11753974 (1), 16104903 (1) (see all 5) |
| prostatic diseases |
56.8 |
3 |
15378521 (1), 9033261 (1) |
| prostate carcinoma |
55 |
12 |
11753974 (4), 8889697 (1), 7664987 (1), 11745444 (1) (see all 7) |
| cancer |
37.9 |
21 |
9187691 (3), 20424135 (2), 10209959 (1), 19147544 (1) (see all 13) |
| metastasis |
18 |
6 |
15100735 (2), 11486050 (1), 10209959 (1), 11745444 (1) |
| tumors |
17.3 |
28 |
9033261 (5), 18627344 (3), 9187691 (2), 8889697 (1) (see all 12) |
| breast cancer |
15.5 |
9 |
9205072 (4), 10675891 (1), 11782391 (1), 19372141 (1) (see all 5) |
| adenocarcinoma |
0 |
5 |
9187691 (3), 1691151 (1) |
Genetic Association Database (GAD): KLK2
Human Genome Epidemiology (HuGE) Navigator: KLK2 (24 documents)
Export disorders for KLK2 gene to outside databases
|
Publications
for KLK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLK2 gene, integrated from 9 sources (see all 147):
(articles sorted by number of sources associating them with KLK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection. (PubMed id 12805332)1, 4, 9 Nam R.K....Narod S.A. (2003)
- Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2, 9 Gan L.... Wang K. (2000)
- Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing. (PubMed id 10544017)1, 2, 9 Liu X.F.... Pastan I. (1999)
- Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
- A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)
- Human kallikrein-2 gene polymorphism is associated with the occurrence of prostate cancer. (PubMed id 15643194)1, 4 Chiang C.H....Chen K.K. (2005)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans. (PubMed id 11130770)1, 4 Gainer J.V....Bachvarov D.R. (2000)
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External Searches for KLK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing KLK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing KLK2 gene
(According to HUGE)
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Specialized Databases showing KLK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for KLK2 gene:
Search GeneIP for patents involving KLK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KLK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for KLK2 | | OriGene shRNA RFP for KLK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK2 | | | OriGene Protein Over-expression Lysate for KLK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLK2 | | OriGene 3'-UTR Clone for KLK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KLK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLK2 | | OriGene Custom Protein Services for KLK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK2 |
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| | | | Search Tocris compounds for KLK2 |
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 | | | KLK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK2 |
|  |  |  | | | | ThermoFisher Antibodies for KLK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK2 |
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