Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK2 Gene

protein-coding   GIFtS: 70
GCID: GC19P051376

Kallikrein-Related Peptidase 2

(Previous names: kallikrein 2, prostatic)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 21 2     Glandular Kallikrein 22
Kallikrein 2, Prostatic1 2     hK22
Glandular Kallikrein-12 3     kallikrein-22
Tissue Kallikrein-22 3     EC 3.4.21.353
hGK-12 3     EC 3.4.218
KLK2A22     

External Ids:    HGNC: 63631   Entrez Gene: 38172   Ensembl: ENSG000001677517   OMIM: 1479605   UniProtKB: P201513   

Export aliases for KLK2 gene to outside databases

Previous GC identifers: GC19P052005 GC19P051737 GC19P056052 GC19P056068 GC19P047711


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK2 Gene:
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine
proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of
biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that
selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is
responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly
expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing
results in both coding and non-coding transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for KLK2 Gene: 
KLK2 (kallikrein-related peptidase 2) is a protein-coding gene. Diseases associated with KLK2 include prostate disease, and prostatitis, and among its related super-pathways are Collagen biosynthesis and modifying enzymes and Degradation of collagen. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151
Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

Gene Wiki entry for KLK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK2 gene promoter:
         NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

KLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051376:  view genomic region     (about GC identifiers)

Start:
51,364,824 bp from pter      End:
51,383,823 bp from pter
Size:
19,000 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151 (See protein sequence)
Recommended Name: Kallikrein-2 precursor  
Size: 261 amino acids; 28671 Da
Sequence caution: Sequence=AAD13817.1; Type=Miscellaneous discrepancy;
Secondary accessions: B4DU93 B4DUB0 F5H8L3 Q15946 Q9UJZ9
Alternative splicing: 4 isoforms:  P20151-1   P20151-2   P20151-3   P20151-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLK2: NX_P20151

Explore proteomics data for KLK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20151

  • 4/10 DME Specific Peptides for KLK2 (P20151) (see all 10)
     PWQVAVY  SQPWQVA  CGGVLVH  SGGPLVC 

    KLK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLK2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001002231.1  NP_001243009.1  NP_005542.1  

    ENSEMBL proteins: 
     ENSP00000472852   ENSP00000313581   ENSP00000469318   ENSP00000472095   ENSP00000471014  
     ENSP00000469770   ENSP00000472499   ENSP00000350748   ENSP00000471214   ENSP00000471323  
     ENSP00000471725   ENSP00000471321   ENSP00000375686  
    Reactome Protein details: P20151
    Human Recombinant Protein Products for KLK2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for KLK2 (Kallikrein 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KLK2
    OriGene Protein Over-expression Lysate for KLK2
    OriGene MassSpec for KLK2 
    OriGene Custom Protein Services for KLK2
    GenScript Custom Purified and Recombinant Proteins Services for KLK2
    Novus Biologicals KLK2 Protein
    Novus Biologicals KLK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLK2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    KLK2 for ontologies           About GeneDecksing



    KLK2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KLK2 (Kallikrein 2)
    OriGene Antibodies for KLK2
    OriGene Custom Antibody Services for KLK2
    GenScript Custom Superior Antibodies Services for KLK2
    Novus Biologicals KLK2 Antibodies
    Abcam antibodies for KLK2
    Cloud-Clone Corp. Antibodies for KLK2 
    ThermoFisher Antibodies for KLK2
    LSBio Antibodies in human, mouse, rat for KLK2 

    Assay Products for KLK2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLK2
    Browse R&D Systems for biochemical assays
    GenScript KLK2-Activity-based Protease Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLK2 
    Cloud-Clone Corp. CLIAs for KLK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P20151

    ProtoNet protein and cluster: P20151

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK2_HUMAN, P20151
    Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin
    Catalytic activity: Preferential cleavage of Arg- -Xaa bonds in small molecule substrates. Highly selective action
    to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met- -Xaa or Leu- -Xaa

         Genatlas biochemistry entry for KLK2:
    kallikrein 2,glandular,expressed in the prostate,complexing with protease inhibitor 6 in prostate cancer tissue

         Enzyme Numbers (IUBMB): EC 3.4.21.351 EC 3.4.212

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA9042371
         
    KLK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLK2:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLK2
    SwitchGear 3'UTR luciferase reporter plasmidKLK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLK2
    Sirion Biotech Customized adenovirus for overexpression of KLK2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KLK2 (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KLK2 (NM_001002231)
    Sino Biological Human cDNA Clone for KLK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK2
    Sirion Biotech Customized lentivirus for stable overexpression of KLK2 
                         Customized lentivirus expression plasmids for stable overexpression of KLK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLK2
    Search LifeMap BioReagents cell lines for KLK2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLK2 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.40
    Blood Coagulation Cascade0.39
    Extracellular matrix organization0.39
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Activation of Matrix Metalloproteinases0.40
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Prostate Cancer
    Prostate Cancer0.32
    5Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KLK2
        Cell adhesion ECM remodeling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK2
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    1 GeneGo (Thomson Reuters) Pathway for KLK2
        Cell adhesion ECM remodeling

    3 BioSystems Pathways for KLK2
        Prostate Cancer
    Regulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    5        Reactome Pathways for KLK2
        Extracellular matrix organization
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins
    Degradation of the extracellular matrix
    Activation of Matrix Metalloproteinases


    1         Kegg Pathway  (Kegg details for KLK2):
        Endocrine and other factor-regulated calcium reabsorption


    KLK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for KLK2 (P201513 ENSP000003135814) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    SERPINA5P051543, ENSP000003332034I2D: score=2 STRING: ENSP00000333203
    SERPINB6P352373, ENSP000003383584I2D: score=2 STRING: ENSP00000338358
    SERPINF2P086973, ENSP000003218534I2D: score=2 STRING: ENSP00000321853
    IGFBP2P180653, ENSP000002338094I2D: score=1 STRING: ENSP00000233809
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    KLK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for KLK2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLK2

    2 HMDB Compounds for KLK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SomatostatinGrowth hormone release inhibiting factor;Somatostatin-14;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys ----
    Somatostatin fragment 3-14Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys [Disulfide bridge: 3-14] ----

    6 Novoseek inferred chemical compound relationships for KLK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 63.9 14 10438493 (1), 10583401 (1), 20128684 (1), 10024471 (1) (see all 11)
    progestins 50 2 9205072 (1)
    dihydrotestosterone 46.5 2 1370633 (1), 20043108 (1)
    testosterone 41.8 24 10197620 (4), 9241247 (3), 12767274 (2), 1370633 (1) (see all 8)
    steroid 14.8 3 11948967 (1), 19147544 (1), 9205072 (1)
    oligonucleotide 12.3 3 7515392 (1), 1691151 (1)

    Search CenterWatch for drugs/clinical trials and news about KLK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLK2 gene (4 alternative transcripts): 
    NM_001002231.2  NM_001256080.1  NM_005551.4  NM_001002232.2  

    Unigene Cluster for KLK2:

    Kallikrein-related peptidase 2
    Hs.515560  [show with all ESTs]
    Unigene Representative Sequence: NR_045763
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000593493 ENST00000595375 ENST00000597509 ENST00000596950 ENST00000325321(uc002ptv.3 uc010ycl.2 uc010ycm.2)
    ENST00000600690 ENST00000599280 ENST00000594174 ENST00000597727 ENST00000595316
    ENST00000599121 ENST00000600755 ENST00000600866 ENST00000358049(uc010eog.3 uc010yck.2 uc002ptu.3 uc002ptt.3)
    ENST00000597439 ENST00000601743 ENST00000599568 ENST00000595173
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLK2
    SwitchGear 3'UTR luciferase reporter plasmidKLK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK2
    Clone
    Products:
         
    OriGene clones in human, mouse for KLK2 (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KLK2 (NM_001002231)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK2
    Sirion Biotech Customized lentivirus for stable overexpression of KLK2 
                         Customized lentivirus expression plasmids for stable overexpression of KLK2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLK2
    OriGene qSTAR qPCR primer pairs in human, mouse for KLK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KLK2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK2

    Additional mRNA sequence: 

    AF188745.1 AF188746.1 AF188747.1 AK300527.1 AK300549.1 AK300566.1 AK309968.1 AK309969.1 
    AK309973.1 AK309982.1 AK309985.1 AK315890.1 AY429509.1 AY429510.1 BC005196.1 BT006650.1 
    NR_045762.1 NR_045763.1 S39329.1 

    24/34 DOTS entries (see all 34):

    DT.121490814  DT.121490591  DT.422516  DT.101963585  DT.85101208  DT.87046802  DT.95359387  DT.121490632 
    DT.121490749  DT.85104723  DT.91756917  DT.100689427  DT.91966580  DT.91756926  DT.101986345  DT.121490688 
    DT.75147406  DT.91858807  DT.92416838  DT.95264855  DT.95264857  DT.97838927  DT.85104722  DT.99973681 

    24/1035 AceView cDNA sequences (see all 1035):

    BF477158 AA595609 BF477115 BF477225 AI989309 BF063478 AA729122 CA487643 
    AI028305 CA488903 CA488067 AI682320 AA535502 BF477018 AI685510 CF146133 
    AA541634 CF139149 CA976184 BQ932072 X05332 T29518 NM_005551 BF475515 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for KLK2 (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b ^ 11a ·
    SP1:                                                  -     -     -                                                           -     -     -     -     -         
    SP2:                                                  -     -     -                                                                 -     -     -     -         
    SP3:                                                  -     -     -                       -                                         -     -     -     -         
    SP4:                    -     -     -                 -     -     -                                                                                             
    SP5:                                                  -     -     -     -                                                                                       

    ExUns: 11b · 11c · 11d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for KLK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGGTTAA
    KLK2 Expression
    About this image


    See KLK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLK2

    SOURCE GeneReport for Unigene cluster: Hs.515560
        SABiosciences Custom PCR Arrays for KLK2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLK2
    OriGene qSTAR qPCR primer pairs in human, mouse for KLK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KLK2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for KLK2 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia KLK26
    arginine esterase precursor
    59(a)
    1 → many
    1(105981210-105984453)


    ENSEMBL Gene Tree for KLK2 (if available)
    TreeFam Gene Tree for KLK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLK2 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    18/77 SIMAP similar genes for KLK2 using alignment to 8 protein entries:     KLK2_HUMAN (see all proteins) (see all similar genes):
    APS    KLK3    KLK1    KLK6    KLK8    C1S
    KLK7    KLK11    KLK9    PRSS1    PRSS45    CFD
    KLK5    KLK4    F9 p22    factor IX F9    PRSS3    KLK13

    KLK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/353 SNPs in KLK2 are shown (see all 353)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs566669521,2
    C--51377471(+) ACAAAACAAA/
            
    GCAAG
    5 -- int11Minor allele frequency- -:0.00NA 2
    rs794493011,2
    C,F--51377487(+) ACAAAA/TCAAAG 5 -- int12Minor allele frequency- T:0.02MN NA 276
    rs26641591,2
    C,F--51378884(+) ACCCCG/ATCTCT 5 -- int12Minor allele frequency- A:0.07WA MN 144
    rs1131833181,2
    C,F--51379041(+) CAGAGC/TAAGAC 5 -- int11Minor allele frequency- T:0.01MN 148
    rs1118599061,2
    C,F--51379042(+) AGAGCA/GAGACT 5 -- int11Minor allele frequency- G:0.01MN 144
    rs1468401701,2
    --51556555(+) TGTGGC/TTGGAT 5 -- us2k10--------
    rs772350641,2
    C,F--51556568(+) GGCTG-/TGTTAA 5 -- us2k11Minor allele frequency- T:0.03MN 156
    rs791782051,2
    C,F--51556576(+) TAAATT/AGGTTT 5 -- us2k12Minor allele frequency- A:0.03MN NA 276
    rs794734881,2
    C,F--51556586(+) TGGGTC/GAGGTT 5 -- us2k12Minor allele frequency- G:0.03MN NA 276
    rs1142907321,2
    C,F--51556587(+) GGGTCA/GGGTTT 5 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for KLK2 (51364824 - 51383823 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2531CNV Loss18451855
    esv1010987CNV Loss20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK2
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147960    OMIM disorders: --

    12 diseases for KLK2:    About MalaCards
    prostate disease    prostatitis    prostate cancer    prostate cancer, progression of
    meningioma    infertility    renal cell carcinoma    hypertension
    adenocarcinoma    breast cancer    lung cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for KLK2:
    Prostate cancer

    KLK2 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for KLK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 78.2 93 17085659 (6), 16322300 (3), 8950360 (3), 11967950 (3) (see all 41)
    benign prostatic hyperplasia 61.3 6 1370633 (1), 10583401 (1), 11753974 (1), 16104903 (1) (see all 5)
    prostatic diseases 56.8 3 15378521 (1), 9033261 (1)
    prostate carcinoma 55 12 11753974 (4), 8889697 (1), 7664987 (1), 11745444 (1) (see all 7)
    cancer 37.9 21 9187691 (3), 20424135 (2), 10209959 (1), 19147544 (1) (see all 13)
    metastasis 18 6 15100735 (2), 11486050 (1), 10209959 (1), 11745444 (1)
    tumors 17.3 28 9033261 (5), 18627344 (3), 9187691 (2), 8889697 (1) (see all 12)
    breast cancer 15.5 9 9205072 (4), 10675891 (1), 11782391 (1), 19372141 (1) (see all 5)
    adenocarcinoma 0 5 9187691 (3), 1691151 (1)

    Genetic Association Database (GAD): KLK2
    Human Genome Epidemiology (HuGE) Navigator: KLK2 (24 documents)

    Export disorders for KLK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLK2 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with KLK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy. (PubMed id 17085659)1, 4, 9 Nam R.K....Narod S.A. (2006)
    2. Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4, 9 Klein R.J....Lilja H. (2010)
    3. Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection. (PubMed id 12805332)1, 4, 9 Nam R.K....Narod S.A. (2003)
    4. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PubMed id 19372141)1, 4, 9 Lee J.Y....Kang D. (2009)
    5. Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. (PubMed id 17593395)1, 4, 9 Pal P....Deka R. (2007)
    6. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2, 9 Gan L.... Wang K. (2000)
    7. Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing. (PubMed id 10544017)1, 2, 9 Liu X.F.... Pastan I. (1999)
    8. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    9. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    10. Replication of prostate cancer risk loci on 8q24, 11q 13, 17q12, 19q33, and Xp11 in African Americans. (PubMed id 19902474)1, 4 Hooker S....Kittles R.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3817 HGNC: 6363 AceView: KLK3andKLK2 Ensembl:ENSG00000167751 euGenes: HUgn3817
    ECgene: KLK2 Kegg: 3817 H-InvDB: KLK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLK2 gene:
    Search GeneIP for patents involving KLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for KLK2
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KLK2 (Kallikrein 2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for KLK2 (Kallikrein 2)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KLK2   OriGene RNAi products in human, mouse, rat for KLK2  
     OriGene qPCR primer pairs and template standards for KLK2   OriGene Protein Over-expression Lysate for KLK2  
     OriGene MassSpec something-or-other for KLK2   OriGene clones in human, mouse for KLK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLK2   OriGene Purified Protein for KLK2  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLK2   OriGene Custom Protein Services for KLK2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLK2
     QIAGEN SeqTarget long-range PCR primers for resequencing KLK2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK2
     GenScript Custom Purified and Recombinant Proteins Services for KLK2 GenScript cDNA clones with any tag delivered in your preferred vector for KLK2
     GenScript KLK2-Activity-based typehere Assay for Compound Screening GenScript Custom Superior Antibodies Services for KLK2
     GenScript Custom overexpressing Cell Line Services for KLK2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLK2 promoter
     Search Chromatin IP Primers for KLK2
     RT2 qPCR Primer Assay in human, mouse / rat KLK2
     GNC Network for KLK2
     SABiosciences PCR Arrays including human, mouse / rat KLK2
     Search Tocris compounds for KLK2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for KLK2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLK2 antibodies
     KLK2 proteins
     KLK2 lysates
     Antibodies for KLK2
     See all of Abcam's Antibodies, Kits and Proteins for KLK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KLK2
     Antibodies for KLK2
     ELISAs for KLK2
     CLIAs for KLK2
     Search LifeMap BioReagents cell lines for KLK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK2
     SwitchGear 3'UTR luciferase reporter plasmids for KLK2
     SwitchGear Promoter luciferase reporter plasmids for KLK2
     ThermoFisher Antibodies for KLK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLK2
    Customized:
     lentivirus for stable overexpression of KLK2
     lentivirus expression plasmids for stable overexpression of KLK2
     adenovirus for overexpression of KLK2
     LSBio Antibodies in human, mouse, rat for KLK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLK2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4