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KLK2 Gene

protein-coding   GIFtS: 71
GCID: GC19P051369

Kallikrein-Related Peptidase 2

(Previous names: kallikrein 2, prostatic)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 21 2     Glandular Kallikrein 22
Kallikrein 2, Prostatic1 2     hK22
Glandular Kallikrein-12 3     kallikrein-22
Tissue Kallikrein-22 3     EC 3.4.21.353
hGK-12 3     EC 3.4.218
KLK2A22     

External Ids:    HGNC: 63631   Entrez Gene: 38172   Ensembl: ENSG000001677517   OMIM: 1479605   UniProtKB: P201513   

Export aliases for KLK2 gene to outside databases

Previous GC identifers: GC19P052005 GC19P051737 GC19P056052 GC19P056068 GC19P051376 GC19P047711


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK2 Gene:
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine
proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of
biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that
selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is
responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly
expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing
results in both coding and non-coding transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for KLK2 Gene:
KLK2 (kallikrein-related peptidase 2) is a protein-coding gene. Diseases associated with KLK2 include prostate disease, and prostatitis. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151
Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

Gene Wiki entry for KLK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK2 gene promoter:
         NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK2 promoter sequence
   Search Chromatin IP Primers for KLK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

KLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051369:  view genomic region     (about GC identifiers)

Start:
51,364,824 bp from pter      End:
51,383,823 bp from pter
Size:
19,000 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151 (See protein sequence)
Recommended Name: Kallikrein-2 precursor  
Size: 261 amino acids; 28671 Da
Sequence caution: Sequence=AAD13817.1; Type=Miscellaneous discrepancy;
Secondary accessions: B4DU93 B4DUB0 F5H8L3 Q15946 Q9UJZ9
Alternative splicing: 4 isoforms:  P20151-1   P20151-2   P20151-3   P20151-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLK2: NX_P20151

Explore proteomics data for KLK2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn102
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KLK2 (P20151) (see all 10)
     PWQVAVY  SQPWQVA  CGGVLVH  SGGPLVC 


    See KLK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001002231.1  NP_001243009.1  NP_005542.1  

    ENSEMBL proteins: 
     ENSP00000472852   ENSP00000313581   ENSP00000469318   ENSP00000472095   ENSP00000471014  
     ENSP00000469770   ENSP00000472499   ENSP00000350748   ENSP00000471214   ENSP00000471323  
     ENSP00000471725   ENSP00000471321   ENSP00000375686  
    Reactome Protein details: P20151

    KLK2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P20151

    ProtoNet protein and cluster: P20151

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK2_HUMAN, P20151
    Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin
    Catalytic activity: Preferential cleavage of Arg- -Xaa bonds in small molecule substrates. Highly selective action
    to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met- -Xaa or Leu- -Xaa

         Genatlas biochemistry entry for KLK2:
    kallikrein 2,glandular,expressed in the prostate,complexing with protease inhibitor 6 in prostate cancer tissue

         Enzyme Numbers (IUBMB): EC 3.4.21.351 EC 3.4.212

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA9042371
         
    KLK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLK2:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK2
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    Sino Biological Human cDNA Clone for KLK2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol1
    lysosome1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    KLK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK2 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Matrix Metalloproteinases
    Activation of Matrix Metalloproteinases0.37
    4Prostate Cancer
    Prostate Cancer0.32
    5Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK2
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    1 GeneGo (Thomson Reuters) Pathway for KLK2
        Cell adhesion ECM remodeling

    3 BioSystems Pathways for KLK2
        Prostate Cancer
    Regulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    2 Reactome Pathways for KLK2
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Activation of Matrix Metalloproteinases


    1 Kegg Pathway  (Kegg details for KLK2):
        Endocrine and other factor-regulated calcium reabsorption


    KLK2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK2
    Interactions:

        GeneGlobe Interaction Network for KLK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for KLK2 (P201513 ENSP000003135814) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    SERPINA5P051543, ENSP000003332034I2D: score=2 STRING: ENSP00000333203
    SERPINB6P352373, ENSP000003383584I2D: score=2 STRING: ENSP00000338358
    SERPINF2P086973, ENSP000003218534I2D: score=2 STRING: ENSP00000321853
    IGFBP2P180653, ENSP000002338094I2D: score=1 STRING: ENSP00000233809
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    KLK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK2

    2 HMDB Compounds for KLK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SomatostatinGrowth hormone release inhibiting factor;Somatostatin-14;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys ----
    Somatostatin fragment 3-14Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys [Disulfide bridge: 3-14] ----

    6 Novoseek inferred chemical compound relationships for KLK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 63.9 14 10438493 (1), 10583401 (1), 20128684 (1), 10024471 (1) (see all 11)
    progestins 50 2 9205072 (1)
    dihydrotestosterone 46.5 2 1370633 (1), 20043108 (1)
    testosterone 41.8 24 10197620 (4), 9241247 (3), 12767274 (2), 1370633 (1) (see all 8)
    steroid 14.8 3 11948967 (1), 19147544 (1), 9205072 (1)
    oligonucleotide 12.3 3 7515392 (1), 1691151 (1)



    KLK2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLK2 gene (4 alternative transcripts): 
    NM_001002231.2  NM_001256080.1  NM_005551.4  NM_001002232.2  

    Unigene Cluster for KLK2:

    Kallikrein-related peptidase 2
    Hs.515560  [show with all ESTs]
    Unigene Representative Sequence: NR_045763
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000593493 ENST00000595375 ENST00000597509 ENST00000596950 ENST00000325321(uc002ptv.3 uc010ycl.2 uc010ycm.2)
    ENST00000600690 ENST00000599280 ENST00000594174 ENST00000597727 ENST00000595316
    ENST00000599121 ENST00000600755 ENST00000600866 ENST00000358049(uc010eog.3 uc010yck.2 uc002ptu.3 uc002ptt.3)
    ENST00000597439 ENST00000601743 ENST00000599568 ENST00000595173
    miRNA
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    Additional mRNA sequence: 

    AF188745.1 AF188746.1 AF188747.1 AK300527.1 AK300549.1 AK300566.1 AK309968.1 AK309969.1 
    AK309973.1 AK309982.1 AK309985.1 AK315890.1 AY429509.1 AY429510.1 BC005196.1 BT006650.1 
    NR_045762.1 NR_045763.1 S39329.1 

    Selected DOTS entries (see all 34):

    DT.121490814  DT.121490591  DT.422516  DT.101963585  DT.85101208  DT.87046802  DT.95359387  DT.121490632 
    DT.121490749  DT.85104723  DT.91756917  DT.100689427  DT.91966580  DT.91756926  DT.101986345  DT.121490688 
    DT.75147406  DT.91858807  DT.92416838  DT.95264855  DT.95264857  DT.97838927  DT.85104722  DT.99973681 

    Selected AceView cDNA sequences (see all 1035):

    AI685510 CF146133 AA541634 CF139149 CA976184 BQ932072 X05332 T29518 
    BF447250 CA487655 BF477158 BQ925109 BQ884242 NM_145864 BF001040 AI989309 
    BF477115 BF477225 BX099872 NM_001002232 CA454428 NM_001002231 BX504463 CA488291 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLK2 (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b ^ 11a ·
    SP1:                                                  -     -     -                                                           -     -     -     -     -         
    SP2:                                                  -     -     -                                                                 -     -     -     -         
    SP3:                                                  -     -     -                       -                                         -     -     -     -         
    SP4:                    -     -     -                 -     -     -                                                                                             
    SP5:                                                  -     -     -     -                                                                                       

    ExUns: 11b · 11c · 11d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for KLK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGGTTAA
    KLK2 Expression
    About this image

    KLK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515560
        Custom PCR Arrays for KLK2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLK2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    1 → many
    GL343514.1(217681-240007)
            Species with no ortholog for KLK2

    ENSEMBL Gene Tree for KLK2 (if available)
    TreeFam Gene Tree for KLK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK2 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK2 using alignment to 8 protein entries:     KLK2_HUMAN (see all proteins) (see all similar genes):
    APS    KLK1    KLK3    KLK6    KLK8    C1S
    KLK7    KLK11    KLK9    PRSS1    PRSS45    CFD
    KLK5    KLK4    F9 p22    factor IX F9    KLK13    KLK14

    KLK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK2 (see all 353)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs566669521,2
    C--51377471(+) ACAAAACAAA/
            
    GCAAG
    5 -- int11Minor allele frequency- -:0.00NA 2
    rs794493011,2
    C,F--51377487(+) ACAAAA/TCAAAG 5 -- int12Minor allele frequency- T:0.02MN NA 276
    rs26641591,2
    C,F--51378884(+) ACCCCG/ATCTCT 5 -- int12Minor allele frequency- A:0.07WA MN 144
    rs1131833181,2
    C,F--51379041(+) CAGAGC/TAAGAC 5 -- int11Minor allele frequency- T:0.01MN 148
    rs1118599061,2
    C,F--51379042(+) AGAGCA/GAGACT 5 -- int11Minor allele frequency- G:0.01MN 144
    rs1468401701,2
    --51556555(+) TGTGGC/TTGGAT 5 -- us2k10--------
    rs772350641,2
    C,F--51556568(+) GGCTG-/TGTTAA 5 -- us2k11Minor allele frequency- T:0.03MN 156
    rs791782051,2
    C,F--51556576(+) TAAATT/AGGTTT 5 -- us2k12Minor allele frequency- A:0.03MN NA 276
    rs794734881,2
    C,F--51556586(+) TGGGTC/GAGGTT 5 -- us2k12Minor allele frequency- G:0.03MN NA 276
    rs1142907321,2
    C,F--51556587(+) GGGTCA/GGGTTT 5 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for KLK2 (51364824 - 51383823 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2531CNV Loss18451855
    esv1010987CNV Loss20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK2
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147960    OMIM disorders: --

    13 diseases for KLK2:    
    About MalaCards
    prostate disease    prostatitis    prostate cancer    childhood leukemia
    meningioma    infertility    renal cell carcinoma    hypertension
    breast cancer    adenocarcinoma    lung cancer    leukemia
    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for KLK2:
    Prostate cancer

    KLK2 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for KLK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 78.2 93 17085659 (6), 16322300 (3), 8950360 (3), 11967950 (3) (see all 41)
    benign prostatic hyperplasia 61.3 6 1370633 (1), 10583401 (1), 11753974 (1), 16104903 (1) (see all 5)
    prostatic diseases 56.8 3 15378521 (1), 9033261 (1)
    prostate carcinoma 55 12 11753974 (4), 8889697 (1), 7664987 (1), 11745444 (1) (see all 7)
    cancer 37.9 21 9187691 (3), 20424135 (2), 10209959 (1), 19147544 (1) (see all 13)
    metastasis 18 6 15100735 (2), 11486050 (1), 10209959 (1), 11745444 (1)
    tumors 17.3 28 9033261 (5), 18627344 (3), 9187691 (2), 8889697 (1) (see all 12)
    breast cancer 15.5 9 9205072 (4), 10675891 (1), 11782391 (1), 19372141 (1) (see all 5)
    adenocarcinoma 0 5 9187691 (3), 1691151 (1)

    Genetic Association Database (GAD): KLK2
    Human Genome Epidemiology (HuGE) Navigator: KLK2 (24 documents)

    Export disorders for KLK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK2 gene, integrated from 10 sources (see all 151):
    (articles sorted by number of sources associating them with KLK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy. (PubMed id 17085659)1, 4, 9 Nam R.K....Narod S.A. (Clin. Cancer Res. 2006)
    2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4, 9 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    3. Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection. (PubMed id 12805332)1, 4, 9 Nam R.K....Narod S.A. (J. Clin. Oncol. 2003)
    4. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PubMed id 19372141)1, 4, 9 Lee J.Y....Kang D. (Carcinogenesis 2009)
    5. Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. (PubMed id 17593395)1, 4, 9 Pal P....Deka R. (Hum. Genet. 2007)
    6. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2, 9 Gan L.... Wang K. (Gene 2000)
    7. Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing. (PubMed id 10544017)1, 2, 9 Liu X.F.... Pastan I. (Biochem. Biophys. Res. Commun. 1999)
    8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    9. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    10. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. (PubMed id 19902474)1, 4 Hooker S....Kittles R.A. (Prostate 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3817 HGNC: 6363 AceView: KLK3andKLK2 Ensembl:ENSG00000167751 euGenes: HUgn3817
    ECgene: KLK2 Kegg: 3817 H-InvDB: KLK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK2 gene:
    Search GeneIP for patents involving KLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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