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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK15 Gene

protein-coding   GIFtS: 60
GCID: GC19M051328

Kallikrein-Related Peptidase 15

(Previous name: kallikrein 15)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 151 2     Kallikrein-Like Serine Protease2
ACO Protease2 3     prostinogen2
Kallikrein 151     EC 3.4.21.-3
ACO2     EC 3.4.218
HSRNASPH2     EC 3.4.21.48
kallikrein-152     

External Ids:    HGNC: 204531   Entrez Gene: 555542   Ensembl: ENSG000001745627   OMIM: 6106015   UniProtKB: Q9H2R53   

Export aliases for KLK15 gene to outside databases

Previous GC identifers: GC19M051957 GC19M051689 GC19M056004 GC19M056020 GC19M047663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK15 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or
prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing
results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLK15 Gene: 
KLK15 (kallikrein-related peptidase 15) is a protein-coding gene. Diseases associated with KLK15 include bronchogenic carcinoma, and peripheral vascular disease, and among its related super-pathways are Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK15_HUMAN, Q9H2R5
Function: Protease whose physiological substrate is not yet known

Gene Wiki entry for KLK15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK15 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK15 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.4

KLK15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK15 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051328:  view genomic region     (about GC identifiers)

Start:
51,328,545 bp from pter      End:
51,340,469 bp from pter
Size:
11,925 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLK15_HUMAN, Q9H2R5 (See protein sequence)
Recommended Name: Kallikrein-15 precursor  
Size: 256 amino acids; 28087 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A0AUY8 Q15358 Q9H2R3 Q9H2R4 Q9H2R6 Q9HBG9
Alternative splicing: 4 isoforms:  Q9H2R5-1   Q9H2R5-2   Q9H2R5-3   Q9H2R5-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for KLK15: NX_Q9H2R5

Explore proteomics data for KLK15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2R5

  • 4/8 DME Specific Peptides for KLK15 (Q9H2R5) (see all 8)
     QGIVSWG  SQPWQVA  SGGPLVC  GDSGGPL 

    KLK15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLK15 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001264010.1  NP_001264011.1  NP_059979.2  

    ENSEMBL proteins: 
     ENSP00000314783   ENSP00000469315   ENSP00000471164   ENSP00000468856   ENSP00000472523  
     ENSP00000415136   ENSP00000301421  

    Human Recombinant Protein Products for KLK15: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for KLK15 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--

    KLK15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9H2R5

    ProtoNet protein and cluster: Q9H2R5

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK15_HUMAN, Q9H2R5
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK15_HUMAN, Q9H2R5
    Function: Protease whose physiological substrate is not yet known

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS11010966
    GO:0008236serine-type peptidase activity TAS8018728
         
    KLK15 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KLK15:
     Increased gamma-H2AX phosphory  Large nuclei 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK15 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK15 
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    hsa-miR-224 hsa-miR-185* hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLK15 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLK15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.40
    Blood Coagulation Cascade0.39
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK15
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLK15

    1 Interacting protein for KLK15 (Q9H2R53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOOK2Q96ED93I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS--

    KLK15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLK15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLK15

    4 Novoseek inferred chemical compound relationships for KLK15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 69 18 8328387 (1), 7508789 (1), 7543009 (1), 9028629 (1) (see all 18)
    progestins 51.6 1 12915603 (1)
    steroid 26.9 2 11010966 (1), 12915603 (1)
    testosterone 21.1 1 12439720 (1)

    Search CenterWatch for drugs/clinical trials and news about KLK15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLK15 gene (6 alternative transcripts): 
    NM_001277081.1  NM_001277082.1  NM_017509.3  NM_023006.1  NM_138563.1  NM_138564.1  

    Unigene Cluster for KLK15:

    Kallikrein-related peptidase 15
    Hs.567535  [show with all ESTs]
    Unigene Representative Sequence: NM_017509
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601680 ENST00000326856(uc002ptl.3 uc002pto.3 uc010ych.2)
    ENST00000596531 ENST00000598239 ENST00000596931 ENST00000602114 ENST00000598673
    ENST00000416184(uc002ptm.3) ENST00000301421(uc002ptn.3 uc010yci.2 uc010eod.3)


    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK15:
    hsa-miR-224 hsa-miR-185* hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLK15 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF303046.1 BC069480.1 BC069507.1 BC069518.1 BC126137.1 BC144045.1 BC144046.1 BC144047.1 
    NR_102274.1 

    3 DOTS entries:

    DT.102821249  DT.101979218  DT.100745624 

    19 AceView cDNA sequences:

    NM_138563 AY373374 BC069480 BX280958 NM_138564 AY373373 BC069518 NM_023006 
    NM_017509 AW205420 BP431386 BC069507 CA432733 AW274270 BP428687 BP431267 
    AF303046 X75363 CF139951 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KLK15    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:        -     -                                       


    ECgene alternative splicing isoforms for KLK15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLK15 expression in normal human tissues (normalized intensities)      KLK15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACAGAACG
    KLK15 Expression
    About this image


    KLK15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             sigmoid colon mucosa   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)
             salivary gland ; glandular cells   
     
     Thyroid (Endocrine System)
             thyroid gland ; glandular cells   
     
     Lung (Respiratory System)
             lung ; macrophages   

    See KLK15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLK15

    SOURCE GeneReport for Unigene cluster: Hs.567535

    UniProtKB/Swiss-Prot: KLK15_HUMAN, Q9H2R5
    Tissue specificity: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal
    glands and in the colon testis and kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLK15 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk151 , 5 kallikrein related-peptidase 151, 5 78.92(n)1
    77.08(a)1
      7 (28.41 cM)5
    3176521  NM_174865.11  NP_777354.11 
     439337715 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    45(a)
    40(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    GL343276.1(1578128-1583778)
    GL343276.1(1631121-1647585)


    ENSEMBL Gene Tree for KLK15 (if available)
    TreeFam Gene Tree for KLK15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLK15 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK22  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    18/64 SIMAP similar genes for KLK15 using alignment to 6 protein entries:     KLK15_HUMAN (see all proteins) (see all similar genes):
    KLK11    KLK8    KLK6    PRSS1    KLK9    KLK12
    TRY8    PRSS2    CELA3A    PRSS3    KLK7    KLK5
    TRY6    KLK13    KLK4    KLK14    KLK1    KLK10

    KLK15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in KLK15 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362984
    A breast cancer sample4--see VAR_0362982 A T mis40--------
    rs1422715091,2
    C--47666239(+) CCCTG-/TGTTTT 4 -- int10--------
    rs743133221,2
    C,F--47666243(+) TGTTTT/-TTTKT 4 -- int11Minor allele frequency- -:0.02MN 84
    rs559041011,2
    C--47666247(+) TTTTG-/T/TG  
            
    TTTGT
    4 -- int10--------
    rs558148211,2
    C--51331204(+) TTTTT-/T/TG  
            
    GTTTG
    4 -- int12NA 4
    rs3722294211,2
    C--51331208(+) TGTTT-/T/TG  
            
    GTTGT
    4 -- int12CSA 4
    rs44353671,2
    C,F,H--51332311(+) ATACAC/TACACA 4 -- int13Minor allele frequency- T:0.33NA CSA 6
    rs1119948101,2
    F--51332893(+) ACTAAT/AAAATA 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs1120034341,2
    C,F--51335279(+) TCACCG/ATGTTA 4 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs107174561,2
    C,F--51335385(+) CTCAAC/-CCTCT 4 -- us2k13Minor allele frequency- -:0.15NA MN CSA 116

    HapMap Linkage Disequilibrium report for KLK15 (51328545 - 51340469 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KLK15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422090CNV Deletion20811451
    esv2662649CNV Deletion23128226
    dgv203n21CNV Loss19592680
    nsv515608CNV Loss19592680
    dgv3977n71CNV Loss21882294
    nsv2531CNV Loss18451855
    dgv204n21CNV Loss19592680


    Human Gene Mutation Database (HGMD): KLK15
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK15
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610601    OMIM disorders: --

    11 diseases for KLK15:    About MalaCards
    bronchogenic carcinoma    peripheral vascular disease    prostate cancer    vascular disease
    prostatitis    meningioma    breast cancer    alzheimer's disease
    ovarian cancer    thyroiditis    leukemia

    1 disease from the University of Copenhagen DISEASES database for KLK15:
    Bronchogenic carcinoma

    KLK15 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for KLK15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 52.9 3 11010966 (3)
    prostate carcinoma 35 1 11434875 (1)
    breast carcinoma 23.5 1 12439720 (1)
    breast cancer 15.4 2 12439720 (2)
    cancer 0 1 12915603 (1)

    Genetic Association Database (GAD): KLK15
    Human Genome Epidemiology (HuGE) Navigator: KLK15 (11 documents)

    Export disorders for KLK15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLK15 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with KLK15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human kallikrein 15 gene (KLK15). Up- regulation in prostate cancer. (PubMed id 11010966)1, 2, 3, 9 Yousef G.M.... Diamandis E.P. (2001)
    2. The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer. (PubMed id 12439720)1, 3, 9 Yousef G.M....Diamandis E.P. (2002)
    3. Replication of prostate cancer risk loci on 8q24, 11q 13, 17q12, 19q33, and Xp11 in African Americans. (PubMed id 19902474)1, 4 Hooker S....Kittles R.A. (2010)
    4. Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (2010)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    7. Susceptibility loci associated with prostate cancer p rogression and mortality. (PubMed id 20460480)1, 4 Gallagher D.J....Offit K. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
    10. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55554 HGNC: 20453 AceView: KLK15 Ensembl:ENSG00000174562 euGenes: HUgn55554
    ECgene: KLK15 H-InvDB: KLK15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLK15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLK15 gene:
    Search GeneIP for patents involving KLK15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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