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Aliases for KLK15 Gene

Aliases for KLK15 Gene

  • Kallikrein-Related Peptidase 15 2 3
  • ACO Protease 3 4
  • Kallikrein-Like Serine Protease 3
  • Kallikrein 15 2
  • Kallikrein-15 3
  • Prostinogen 3
  • EC 3.4.21.4 64
  • EC 3.4.21.- 4
  • EC 3.4.21 64
  • HSRNASPH 3
  • ACO 3

External Ids for KLK15 Gene

Summaries for KLK15 Gene

Entrez Gene Summary for KLK15 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK15 Gene

KLK15 (Kallikrein-Related Peptidase 15) is a Protein Coding gene. Diseases associated with KLK15 include peripheral vascular disease and bronchogenic carcinoma. Among its related pathways are Collagen biosynthesis and modifying enzymes and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK15 Gene

  • Protease whose physiological substrate is not yet known

Gene Wiki entry for KLK15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK15 Gene

Genomics for KLK15 Gene

Genomic Location for KLK15 Gene

Start:
50,825,289 bp from pter
End:
50,837,213 bp from pter
Size:
11,925 bases
Orientation:
Minus strand

Genomic View for KLK15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK15 Gene

Regulatory Elements for KLK15 Gene

Transcription factor binding sites by QIAGEN in the KLK15 gene promoter:

Proteins for KLK15 Gene

  • Protein details for KLK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2R5-KLK15_HUMAN
    Recommended name:
    Kallikrein-15
    Protein Accession:
    Q9H2R5
    Secondary Accessions:
    • A0AUY8
    • Q15358
    • Q6ISI0
    • Q9H2R3
    • Q9H2R4
    • Q9H2R6
    • Q9HBG9

    Protein attributes for KLK15 Gene

    Size:
    256 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK15 Gene

Proteomics data for KLK15 Gene at MOPED

Selected DME Specific Peptides for KLK15 Gene

Post-translational modifications for KLK15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLK15 Gene

Domains for KLK15 Gene

Gene Families for KLK15 Gene

HGNC:
  • KLK :Kallikreins

UniProtKB/Swiss-Prot:

KLK15_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • Q9H2R5
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.:
    • Q9H2R5
genes like me logo Genes that share domains with KLK15: view

Function for KLK15 Gene

Molecular function for KLK15 Gene

UniProtKB/Swiss-Prot Function: Protease whose physiological substrate is not yet known

Enzyme Numbers (IUBMB) for KLK15 Gene

Gene Ontology (GO) - Molecular Function for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 11010966
GO:0005515 protein binding IPI 25416956
GO:0008236 serine-type peptidase activity TAS 8018728
genes like me logo Genes that share ontologies with KLK15: view

Phenotypes for KLK15 Gene

GenomeRNAi human phenotypes for KLK15:
genes like me logo Genes that share phenotypes with KLK15: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLK15 Gene

Localization for KLK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK15 Gene COMPARTMENTS Subcellular localization image for KLK15 gene
Compartment Confidence
extracellular 5
nucleus 2
peroxisome 2
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK15: view

Pathways for KLK15 Gene

genes like me logo Genes that share pathways with KLK15: view

Pathways by source for KLK15 Gene

Gene Ontology (GO) - Biological Process for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK15: view

Compounds for KLK15 Gene

(4) Novoseek inferred chemical compound relationships for KLK15 Gene

Compound -log(P) Hits PubMed IDs
serine 69 18
progestins 51.6 1
steroid 26.9 2
testosterone 21.1 1
genes like me logo Genes that share compounds with KLK15: view

Transcripts for KLK15 Gene

Unigene Clusters for KLK15 Gene

Kallikrein-related peptidase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for KLK15 Gene

GeneLoc Exon Structure for
KLK15
ECgene alternative splicing isoforms for
KLK15

Expression for KLK15 Gene

mRNA expression in normal human tissues for KLK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK15 Gene

This gene is overexpressed in Testis (17.7), Colon - Transverse (13.9), Prostate (5.6), and Adrenal Gland (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLK15 Gene

SOURCE GeneReport for Unigene cluster for KLK15 Gene Hs.567535

mRNA Expression by UniProt/SwissProt for KLK15 Gene

Q9H2R5-KLK15_HUMAN
Tissue specificity: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.
genes like me logo Genes that share expressions with KLK15: view

Orthologs for KLK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK15 36
  • 99.48 (n)
  • 99.22 (a)
KLK15 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLK15 36
  • 81.77 (n)
  • 76.17 (a)
KLK15 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK15 36
  • 83.46 (n)
  • 79.69 (a)
mouse
(Mus musculus)
Mammalia Klk15 36
  • 79.61 (n)
  • 77.69 (a)
Klk15 16
Klk15 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLK15 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLK15 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102553035 36
  • 80.38 (n)
  • 79.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17239 38
  • 33 (a)
Species with no ortholog for KLK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK15 Gene

ENSEMBL:
Gene Tree for KLK15 (if available)
TreeFam:
Gene Tree for KLK15 (if available)

Paralogs for KLK15 Gene

genes like me logo Genes that share paralogs with KLK15: view

Variants for KLK15 Gene

Sequence variations from dbSNP and Humsavar for KLK15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs190552 -- 50,834,937(+) CTCTA(C/T)TCTGG upstream-variant-2KB
rs266112 -- 50,828,333(+) GAGAG(C/G)AAGGG intron-variant
rs266113 -- 50,829,225(+) tgaaa(C/T)tttga intron-variant
rs266114 -- 50,829,414(+) AGTCA(C/T)AGGGA intron-variant
rs266115 -- 50,829,982(+) GGTCA(A/G)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK15 Gene

Variant ID Type Subtype PubMed ID
dgv3977n71 CNV Loss 21882294
dgv203n21 CNV Loss 19592680
dgv204n21 CNV Loss 19592680
esv2662649 CNV Deletion 23128226
esv2422090 CNV Deletion 20811451
nsv515608 CNV Loss 19592680
nsv2531 CNV Loss 18451855

Relevant External Links for KLK15 Gene

HapMap Linkage Disequilibrium report
KLK15
Human Gene Mutation Database (HGMD)
KLK15

Disorders for KLK15 Gene

(1) University of Copenhagen DISEASES for KLK15 Gene

(5) Novoseek inferred disease relationships for KLK15 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 52.9 3
prostate carcinoma 35 1
breast carcinoma 23.5 1
breast cancer 15.4 2
cancer 0 1

Relevant External Links for KLK15

Genetic Association Database (GAD)
KLK15
Human Genome Epidemiology (HuGE) Navigator
KLK15
genes like me logo Genes that share disorders with KLK15: view

No data available for UniProtKB/Swiss-Prot for KLK15 Gene

Publications for KLK15 Gene

  1. Molecular cloning of the human kallikrein 15 gene (KLK15). Up- regulation in prostate cancer. (PMID: 11010966) Yousef G.M. … Diamandis E.P. (J. Biol. Chem. 2001) 2 3 4 23
  2. The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer. (PMID: 12439720) Yousef G.M. … Diamandis E.P. (Br. J. Cancer 2002) 2 3 23
  3. Prognostic value of the human kallikrein gene 15 expression in ovarian cancer. (PMID: 12915603) Yousef G.M. … Diamandis E.P. (J. Clin. Oncol. 2003) 3 23
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KLK15 Gene

Sources for KLK15 Gene

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