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Aliases for KLK15 Gene

Aliases for KLK15 Gene

  • Kallikrein Related Peptidase 15 2 3 5
  • ACO Protease 3 4
  • Kallikrein-Like Serine Protease 3
  • Kallikrein 15 2
  • Kallikrein-15 3
  • Prostinogen 3
  • EC 3.4.21.4 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • HSRNASPH 3
  • ACO 3

External Ids for KLK15 Gene

Previous GeneCards Identifiers for KLK15 Gene

  • GC19M051957
  • GC19M051689
  • GC19M056004
  • GC19M056020
  • GC19M051328
  • GC19M047663

Summaries for KLK15 Gene

Entrez Gene Summary for KLK15 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK15 Gene

KLK15 (Kallikrein Related Peptidase 15) is a Protein Coding gene. Diseases associated with KLK15 include Prostate Cancer. Among its related pathways are MSP-RON Signaling and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK11.

UniProtKB/Swiss-Prot for KLK15 Gene

  • Protease whose physiological substrate is not yet known.

Gene Wiki entry for KLK15 Gene

Additional gene information for KLK15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK15 Gene

Genomics for KLK15 Gene

GeneHancer (GH) Regulatory Elements for KLK15 Gene

Promoters and enhancers for KLK15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I050835 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.0 966 1.7 HDGF PKNOX1 ATF1 ARNT SIN3A FEZF1 GLI4 ZNF48 ZNF121 POLR2B KLK15 ZNF175 NUP62 PTOV1-AS2 LINC01869 SNORD88C C19orf48 KLK2 SNORD88B SNORD88A
GH19I050838 Enhancer 0.6 dbSUPER 555.5 -1.7 -1669 1.6 GATAD2A CTCF L3MBTL2 TRIM22 RAD21 ZNF629 NBN ZFP36 CREB1 ZNF143 KLK15 KLK2 C19orf48 LINC01869 SNORD88C SNORD88B SNORD88A IL4I1 ASPDH LOC105372441
GH19I050837 Enhancer 0.6 dbSUPER 550.8 -0.3 -335 0.7 BCOR ZBTB21 KLF17 ZMYM3 ZBTB7A ATF2 ZNF366 BCL11A GLIS1 PATZ1 KLK15 KLK2 LINC01869 C19orf48 SNORD88C SNORD88B SNORD88A LOC105372441 KLK3
GH19I050720 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.4 +113.9 113857 5.7 HDGF SIN3A ZNF2 ZBTB7B POLR2B CBX5 E2F8 FOS KLF13 SP3 CLEC11A C19orf48 GPR32 AKT1S1 SNORD88A SNORD88B SNORD88C LINC01869 NUP62 KLK1
GH19I050896 Enhancer 1.2 Ensembl ENCODE 11.5 -59.9 -59888 1.8 HDGF PKNOX1 IRF4 ZNF766 ZNF143 FOS SP3 JUNB REST ZNF592 KLKP1 ZNF175 ZNF577 NUP62 KLK2 LINC01869 KLK15 KLK1 KLK11 POLD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLK15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLK15 gene promoter:

Genomic Locations for KLK15 Gene

Genomic Locations for KLK15 Gene
chr19:50,825,289-50,837,213
(GRCh38/hg38)
Size:
11,925 bases
Orientation:
Minus strand
chr19:51,328,545-51,340,469
(GRCh37/hg19)

Genomic View for KLK15 Gene

Genes around KLK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK15 Gene

Proteins for KLK15 Gene

  • Protein details for KLK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2R5-KLK15_HUMAN
    Recommended name:
    Kallikrein-15
    Protein Accession:
    Q9H2R5
    Secondary Accessions:
    • A0AUY8
    • Q15358
    • Q6ISI0
    • Q9H2R3
    • Q9H2R4
    • Q9H2R6
    • Q9HBG9

    Protein attributes for KLK15 Gene

    Size:
    256 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK15 Gene

Selected DME Specific Peptides for KLK15 Gene

Q9H2R5:
  • LQGIVSWG
  • GDSGGPL
  • WVLSAAHC
  • SQPWQVA
  • SGGPLVC
  • PGVYTKV
  • VRLGEHN
  • QGIVSWG

Post-translational modifications for KLK15 Gene

  • Glycosylation at posLast=171171 and posLast=232232

Domains & Families for KLK15 Gene

Gene Families for KLK15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for KLK15 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2R5

UniProtKB/Swiss-Prot:

KLK15_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK15: view

Function for KLK15 Gene

Molecular function for KLK15 Gene

UniProtKB/Swiss-Prot Function:
Protease whose physiological substrate is not yet known.

Enzyme Numbers (IUBMB) for KLK15 Gene

Phenotypes From GWAS Catalog for KLK15 Gene

Gene Ontology (GO) - Molecular Function for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11010966
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 8018728
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK15: view
genes like me logo Genes that share phenotypes with KLK15: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK15 Gene

Localization for KLK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK15 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK15 Gene

Pathways & Interactions for KLK15 Gene

genes like me logo Genes that share pathways with KLK15: view

Pathways by source for KLK15 Gene

1 BioSystems pathway for KLK15 Gene

Gene Ontology (GO) - Biological Process for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK15: view

No data available for SIGNOR curated interactions for KLK15 Gene

Drugs & Compounds for KLK15 Gene

(3) Drugs for KLK15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK15: view

Transcripts for KLK15 Gene

Unigene Clusters for KLK15 Gene

Kallikrein-related peptidase 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for KLK15 Gene

GeneLoc Exon Structure for
KLK15
ECgene alternative splicing isoforms for
KLK15

Expression for KLK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK15 Gene

This gene is overexpressed in Testis (x17.7), Colon - Transverse (x13.9), Prostate (x5.6), and Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for KLK15 Gene

This gene is overexpressed in Monocytes (49.8) and Rectum (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK15 Gene



Protein tissue co-expression partners for KLK15 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLK15 Gene:

KLK15

SOURCE GeneReport for Unigene cluster for KLK15 Gene:

Hs.567535

mRNA Expression by UniProt/SwissProt for KLK15 Gene:

Q9H2R5-KLK15_HUMAN
Tissue specificity: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.

Evidence on tissue expression from TISSUES for KLK15 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KLK15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK15 Gene

Orthologs for KLK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK15 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia KLK15 33
  • 83.46 (n)
cow
(Bos Taurus)
Mammalia KLK15 33 34
  • 81.77 (n)
rat
(Rattus norvegicus)
Mammalia LOC102553035 33
  • 80.38 (n)
mouse
(Mus musculus)
Mammalia Klk15 33 16 34
  • 79.61 (n)
oppossum
(Monodelphis domestica)
Mammalia KLK15 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLK15 34
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17239 35
  • 33 (a)
Species where no ortholog for KLK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK15 Gene

ENSEMBL:
Gene Tree for KLK15 (if available)
TreeFam:
Gene Tree for KLK15 (if available)

Paralogs for KLK15 Gene

Variants for KLK15 Gene

Sequence variations from dbSNP and Humsavar for KLK15 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_036298 A breast cancer sample p.Ala137Thr
rs1000290070 -- 50,831,936(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000426976 -- 50,831,595(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000549668 -- 50,825,501(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000704134 -- 50,831,247(-) CCCC/CCC intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLK15 Gene

Variant ID Type Subtype PubMed ID
dgv1058e212 CNV loss 25503493
dgv1802n106 CNV deletion 24896259
dgv203n21 CNV loss 19592680
dgv204n21 CNV loss 19592680
esv2422090 CNV deletion 20811451
esv2662649 CNV deletion 23128226
esv2763099 CNV loss 21179565
esv3556538 CNV deletion 23714750
esv3583463 CNV loss 25503493
esv3583464 CNV loss 25503493
esv3644656 CNV loss 21293372
esv3644657 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv2531 CNV deletion 18451855
nsv515608 CNV loss 19592680

Variation tolerance for KLK15 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK15 Gene

Human Gene Mutation Database (HGMD)
KLK15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK15 Gene

Disorders for KLK15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLK15 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search KLK15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLK15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLK15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK15 Gene

Publications for KLK15 Gene

  1. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer. (PMID: 11010966) Yousef GM … Diamandis EP (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer. (PMID: 12439720) Yousef GM … Diamandis EP (British journal of cancer 2002) 2 3 22 58
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 44 58
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58

Products for KLK15 Gene

Sources for KLK15 Gene

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