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KLK14 Gene

protein-coding   GIFtS: 51
GCID: GC19M051580

Kallikrein-Related Peptidase 14

(Previous name: kallikrein 14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 141 2     kallikrein-142
Kallikrein 141 2     EC 3.4.21.-3
Kallikrein-Like Protein 62 3     KLKL63
KLK-L62 3     EC 3.4.218
hK142 3     

External Ids:    HGNC: 63621   Entrez Gene: 438472   Ensembl: ENSG000001294377   OMIM: 6061355   UniProtKB: Q9P0G33   

Export aliases for KLK14 gene to outside databases

Previous GC identifers: GC19M052211 GC19M051941 GC19M056256 GC19M056272 GC19M047914


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK14 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
An additional transcript variant has been described but its full length nature has not been determined. (provided
by RefSeq, Jul 2008)

GeneCards Summary for KLK14 Gene:
KLK14 (kallikrein-related peptidase 14) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK14_HUMAN, Q9P0G3
Function: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May
activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1,
KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1
and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a
process by which the most superficial corneocytes are shed from the skin surface. May be involved in several
aspects of tumor progression including growth, invasion and angiogenesis

Gene Wiki entry for KLK14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK14 gene promoter:
         AhR   p53   Pax-5   p300   RREB-1   NRSF form 2   GATA-1   YY1   C/EBPalpha   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK14 promoter sequence
   Search Chromatin IP Primers for KLK14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

KLK14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK14 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051580:  view genomic region     (about GC identifiers)

Start:
51,580,752 bp from pter      End:
51,587,502 bp from pter
Size:
6,751 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLK14_HUMAN, Q9P0G3 (See protein sequence)
Recommended Name: Kallikrein-14 precursor  
Size: 267 amino acids; 29122 Da
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
Sequence caution: Sequence=AAD50773.2; Type=Erroneous gene model prediction; Sequence=AAG23260.1; Type=Erroneous
gene model prediction; Sequence=AAK48523.1; Type=Erroneous gene model prediction; Sequence=AAK48524.1;
Type=Erroneous initiation; Sequence=ABU63131.1; Type=Erroneous gene model prediction;
Secondary accessions: A7UNK5 Q1RMZ2 Q6B089

Explore the universe of human proteins at neXtProt for KLK14: NX_Q9P0G3

Explore proteomics data for KLK14 at MOPED

Post-translational modifications: 

  • Proteolytic cleavage of the activation peptide produces the active enzyme1
  • Modification sites at neXtProt
  • 4 DME Specific Peptides for KLK14 (Q9P0G3)
     GDSGGPL  SGGPLVC  CQGDSGGP  DSCQGDSGG 


    See KLK14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071329.2  
    ENSEMBL proteins: 
     ENSP00000156499   ENSP00000375678  

    KLK14 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9P0G3

    ProtoNet protein and cluster: Q9P0G3

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK14_HUMAN, Q9P0G3
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with KLK14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK14_HUMAN, Q9P0G3
    Function: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May
    activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1,
    KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1
    and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a
    process by which the most superficial corneocytes are shed from the skin surface. May be involved in several
    aspects of tumor progression including growth, invasion and angiogenesis
    Enzyme regulation: Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and
    leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a
    regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese
    Biophysicochemical properties: Kinetic parameters: KM=0.3 mM for S-2288; KM=0.2 mM for S-2222; KM=0.2 mM for
    S-2302; KM=0.7 mM for S-2586; KM=0.045 mM for Gln-Ala-Arg synthetic peptide; KM=0.043 mM for Val-Pro-Arg
    synthetic peptide; KM=0.09 mM for Pro-Phe-Arg synthetic peptide; KM=0.278 mM for Phe-Ser-Arg synthetic peptide;
    KM=0.0577 mM for Leu-Gly-Arg synthetic peptide; KM=0.139 mM for Gln-Gly-Arg synthetic peptide; KM=0.173 mM for
    Gly-Pro-Arg synthetic peptide; KM=0.0268 mM for Gln-Arg-Arg synthetic peptide; KM=0.130 mM for Gly-Gly-Arg
    synthetic peptide; KM=0.578 mM for Val-Leu-Lys synthetic peptide; Note=Has a higher catalytic efficiency for the
    trypsin-like enzyme substrates S-2288, S-2222 and S-2302 compared to S-2586 a chymotrypsin-like enzyme substrate.
    Has a lower catalytic activity compared to trypsin towards S-2288, S-2222 and S-2302. Cleaves preferentially
    after Arg residues; pH dependence: Optimum pH is 8.0;
    Induction: Up-regulated by steroid hormone

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS10969073
         
    Find genes that share ontologies with KLK14           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK14_HUMAN, Q9P0G3: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA15654974

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK14 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK14
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway


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    Interactions:

        GeneGlobe Interaction Network for KLK14

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA15654974
    GO:0009566fertilization IDA18482984
    GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway IDA16885167
    GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway IDA16885167
    GO:0048730epidermis morphogenesis IDA17158887

    Find genes that share ontologies with KLK14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK14

    2 Novoseek inferred chemical compound relationships for KLK14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 49.8 3 16434994 (1), 14695222 (1), 15843175 (1)
    steroid 33.6 3 12439719 (1), 16434994 (1), 12858357 (1)



    Find genes that share compounds with KLK14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLK14 gene: 
    NM_022046.4  

    Unigene Cluster for KLK14:

    Kallikrein-related peptidase 14
    Hs.283925  [show with all ESTs]
    Unigene Representative Sequence: NM_022046
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000156499(uc021uyk.1) ENST00000391802(uc002pvs.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat KLK14

    Additional mRNA sequence: 

    BC074904.2 BC074905.2 BC114614.1 

    2 DOTS entries:

    DT.86859184  DT.121436771 

    7 AceView cDNA sequences:

    BF514435 AF283670 NM_022046 AI935298 BC074905 BC074904 AW294668 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLK14 Expression
    About this image

    KLK14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283925

    UniProtKB/Swiss-Prot: KLK14_HUMAN, Q9P0G3
    Tissue specificity: Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid,
    kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40
    tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level).
    Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK14 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk141 , 5 kallikrein related-peptidase 141, 5 76.93(n)1
    73.6(a)1
      7 (28.26 cM)5
    3176531  NM_174866.21  NP_777355.11 
     436904185 


    ENSEMBL Gene Tree for KLK14 (if available)
    TreeFam Gene Tree for KLK14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK14 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK92  
    KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK32  KLK82  
    Selected SIMAP similar genes for KLK14 using alignment to 1 protein entry:     KLK14_HUMAN(see all similar genes):
    KLK7    KLK9    KLK11    KLK5    PRSS1    KLK8
    PRSS3    TRY8    KLK4    KLK6    PRSS2    KLK12
    KLK15    GZMA    GZMK    KLK10    KLK13    GZMB

    Find genes that share paralogs with KLK14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK14 (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865046721,2
    --51580664(+) AATACA/GATGCC 1 -- ds50010--------
    rs621141411,2
    C,F--51580857(+) GGGGCC/TGGGCC 1 -- ds50013Minor allele frequency- T:0.00NA WA CSA 5
    rs129847021,2
    A--51581054(+) actccC/Tgggtc 1 -- ds50010--------
    rs1830618561,2
    --51581127(+) ACTCCC/TGGGTC 1 -- ds50010--------
    rs1136124251,2
    C--51581185(+) GGGCTG/-GGGGC 1 -- ut311Minor allele frequency- -:0.00CSA 2
    rs756261461,2
    C,F--51581253(+) CCCACC/TGTGAA 1 -- ut313Minor allele frequency- T:0.01CSA WA EU 1441
    rs169888771,2
    C,F,H--51581254(+) CCACCG/ATGAAG 1 -- ut31 ese38Minor allele frequency- A:0.02NA NS EA WA EU 1881
    rs1434448931,2
    C--51581265(+) ACCATC/TATTTG 2 * syn10--------
    rs2001397231,2
    C--51581274(+) TGTCCA/CGCATC 2 R L mis10--------
    rs2016905131,2
    --51581327(+) ACACCA/GGGGTA 2 P syn10--------

    HapMap Linkage Disequilibrium report for KLK14 (51580752 - 51587502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLK14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718766CNV Deletion23290073
    esv2718767CNV Deletion23290073
    esv34104CNV Loss18971310

    Human Gene Mutation Database (HGMD): KLK14
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606135    OMIM disorders: --


    Find genes that share disorders with KLK14           About GenesLikeMe

    5 Novoseek inferred disease relationships for KLK14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 46 3 11309303 (1), 12439719 (1), 14695222 (1)
    breast carcinoma 38.5 1 12439719 (1)
    breast cancer 31.5 12 16434994 (4), 12439719 (3), 15843175 (1)
    cancer 2.99 2 14695222 (2)
    tumors 0 4 12858357 (2), 15843175 (1)

    Genetic Association Database (GAD): KLK14
    Human Genome Epidemiology (HuGE) Navigator: KLK14 (1 document)

    Export disorders for KLK14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK14 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with KLK14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Major role of human KLK14 in seminal clot liquefaction. (PubMed id 18482984)1, 2, 9 Emami N.... Diamandis E.P. (J. Biol. Chem. 2008)
    2. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies. (PubMed id 11309303)1, 2, 9 Yousef G.M....Diamandis E.P. (Cancer Res. 2001)
    3. A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. (PubMed id 17158887)1, 2, 9 Borgono C.A.... Diamandis E.P. (J. Biol. Chem. 2007)
    4. Enzymatic profiling of human kallikrein 14 using phage-display substrate technology. (PubMed id 15843175)1, 2, 9 Felber L.M.... Deperthes D. (Biol. Chem. 2005)
    5. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    6. Activation of proteinase-activated receptor-2 by human kallikrein- related peptidases. (PubMed id 17625593)1, 2 Stefansson K.... Egelrud T. (J. Invest. Dermatol. 2008)
    7. Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin. (PubMed id 18056261)1, 2 Emami N. and Diamandis E.P. (J. Biol. Chem. 2008)
    8. Understanding the accuracy of statistical haplotype inference with sequence data of known phase. (PubMed id 17922479)1, 2 Andres A.M....Hixson J.E. (Genet. Epidemiol. 2007)
    9. Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14. (PubMed id 17110383)1, 2 Borgono C.A.... Diamandis E.P. (J. Biol. Chem. 2007)
    10. Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum. (PubMed id 16800737)1, 2 Stefansson K.... Egelrud T. (Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 43847 HGNC: 6362 AceView: KLK14 Ensembl:ENSG00000129437 euGenes: HUgn43847
    ECgene: KLK14 H-InvDB: KLK14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK14 gene:
    Search GeneIP for patents involving KLK14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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