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Aliases for KLK14 Gene

Aliases for KLK14 Gene

  • Kallikrein Related Peptidase 14 2 3 5
  • Kallikrein-Like Protein 6 3 4
  • KLK-L6 3 4
  • Kallikrein-Related Peptidase 14 3
  • Kallikrein 14 2
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • KLKL6 4
  • HK14 4

External Ids for KLK14 Gene

Previous GeneCards Identifiers for KLK14 Gene

  • GC19M052211
  • GC19M051941
  • GC19M056256
  • GC19M056272
  • GC19M051580
  • GC19M047914

Summaries for KLK14 Gene

Entrez Gene Summary for KLK14 Gene

  • This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for KLK14 Gene

KLK14 (Kallikrein Related Peptidase 14) is a Protein Coding gene. Among its related pathways are MSP-RON Signaling and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK14 Gene

  • Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.

Gene Wiki entry for KLK14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK14 Gene

Genomics for KLK14 Gene

Regulatory Elements for KLK14 Gene

Genomic Location for KLK14 Gene

Chromosome:
19
Start:
51,077,495 bp from pter
End:
51,086,458 bp from pter
Size:
8,964 bases
Orientation:
Minus strand

Genomic View for KLK14 Gene

Genes around KLK14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK14 Gene

Proteins for KLK14 Gene

  • Protein details for KLK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0G3-KLK14_HUMAN
    Recommended name:
    Kallikrein-14
    Protein Accession:
    Q9P0G3
    Secondary Accessions:
    • A7UNK5
    • Q1RMZ2
    • Q6B089

    Protein attributes for KLK14 Gene

    Size:
    267 amino acids
    Molecular mass:
    29122 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD50773.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAG23260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAK48523.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAK48524.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABU63131.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KLK14 Gene

Proteomics data for KLK14 Gene at MOPED

Selected DME Specific Peptides for KLK14 Gene

Post-translational modifications for KLK14 Gene

  • Proteolytic cleavage of the activation peptide produces the active enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLK14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for KLK14 (Kallikrein 14)
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLK14

Domains & Families for KLK14 Gene

Gene Families for KLK14 Gene

Suggested Antigen Peptide Sequences for KLK14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0G3

UniProtKB/Swiss-Prot:

KLK14_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK14: view

Function for KLK14 Gene

Molecular function for KLK14 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.3 mM for S-2288 {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.2 mM for S-2222 {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.2 mM for S-2302 {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.7 mM for S-2586 {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.045 mM for Gln-Ala-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.043 mM for Val-Pro-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.09 mM for Pro-Phe-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.278 mM for Phe-Ser-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.0577 mM for Leu-Gly-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.139 mM for Gln-Gly-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.173 mM for Gly-Pro-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.0268 mM for Gln-Arg-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.130 mM for Gly-Gly-Arg synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; KM=0.578 mM for Val-Leu-Lys synthetic peptide {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383}; Note=Has a higher catalytic efficiency for the trypsin-like enzyme substrates S-2288, S-2222 and S-2302 compared to S-2586 a chymotrypsin-like enzyme substrate. Has a lower catalytic activity compared to trypsin towards S-2288, S-2222 and S-2302. Cleaves preferentially after Arg residues.; pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:15654974, ECO:0000269 PubMed:17110383};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese.
UniProtKB/Swiss-Prot Function:
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by steroid hormone.

Enzyme Numbers (IUBMB) for KLK14 Gene

genes like me logo Genes that share phenotypes with KLK14: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK14 Gene

Localization for KLK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK14 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK14 Gene COMPARTMENTS Subcellular localization image for KLK14 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for KLK14 Gene

Pathways & Interactions for KLK14 Gene

genes like me logo Genes that share pathways with KLK14: view

Pathways by source for KLK14 Gene

Interacting Proteins for KLK14 Gene

Gene Ontology (GO) - Biological Process for KLK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009566 fertilization IDA 18482984
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IDA 16885167
GO:0048730 epidermis morphogenesis IDA 17158887
GO:0070684 seminal clot liquefaction IDA 18482984
genes like me logo Genes that share ontologies with KLK14: view

No data available for SIGNOR curated interactions for KLK14 Gene

Drugs & Compounds for KLK14 Gene

(1) Drugs for KLK14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK14: view

Transcripts for KLK14 Gene

mRNA/cDNA for KLK14 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLK14 Gene

Kallikrein-related peptidase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK14 Gene

No ASD Table

Relevant External Links for KLK14 Gene

GeneLoc Exon Structure for
KLK14
ECgene alternative splicing isoforms for
KLK14

Expression for KLK14 Gene

mRNA expression in normal human tissues for KLK14 Gene

mRNA differential expression in normal tissues according to GTEx for KLK14 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.6), Vagina (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for KLK14 Gene

This gene is overexpressed in Saliva (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK14 Gene



SOURCE GeneReport for Unigene cluster for KLK14 Gene Hs.283925

mRNA Expression by UniProt/SwissProt for KLK14 Gene

Q9P0G3-KLK14_HUMAN
Tissue specificity: Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level).
genes like me logo Genes that share expression patterns with KLK14: view

Protein tissue co-expression partners for KLK14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KLK14 Gene

Orthologs for KLK14 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK14 35
  • 80.53 (n)
  • 77.6 (a)
KLK14 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK14 35
  • 83.4 (n)
  • 79.28 (a)
KLK14 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk14 35
  • 76.93 (n)
  • 73.6 (a)
Klk14 16
Klk14 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk14 35
  • 77.2 (n)
  • 75.6 (a)
oppossum
(Monodelphis domestica)
Mammalia KLK14 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLK14 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17239 37
  • 38 (a)
CG6041 37
  • 36 (a)
Species with no ortholog for KLK14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK14 Gene

ENSEMBL:
Gene Tree for KLK14 (if available)
TreeFam:
Gene Tree for KLK14 (if available)

Paralogs for KLK14 Gene

genes like me logo Genes that share paralogs with KLK14: view

Variants for KLK14 Gene

Sequence variations from dbSNP and Humsavar for KLK14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35287116 - 51,081,694(+) GGCTC(C/T)GTGTC reference, missense
rs2569491 - 51,081,659(+) CGTAT(A/G)GCCAC reference, missense
rs2569490 - 51,081,601(+) AGCGG(C/T)GCCTG reference, missense
rs1815131 -- 51,080,798(+) cctcc(C/T)gagtg intron-variant
rs1880414 -- 51,081,023(-) CTAGT(C/T)TATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK14 Gene

Variant ID Type Subtype PubMed ID
esv34104 CNV Loss 18971310
esv2718766 CNV Deletion 23290073
esv2718767 CNV Deletion 23290073

Variation tolerance for KLK14 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.36; 88.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK14 Gene

HapMap Linkage Disequilibrium report
KLK14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK14 Gene

Disorders for KLK14 Gene

Relevant External Links for KLK14

Genetic Association Database (GAD)
KLK14
Human Genome Epidemiology (HuGE) Navigator
KLK14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK14

No disorders were found for KLK14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK14 Gene

Publications for KLK14 Gene

  1. Major role of human KLK14 in seminal clot liquefaction. (PMID: 18482984) Emami N. … Diamandis E.P. (J. Biol. Chem. 2008) 3 4 23 67
  2. A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. (PMID: 17158887) Borgono C.A. … Diamandis E.P. (J. Biol. Chem. 2007) 3 23
  3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 3
  4. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A. … Yousef G.M. (Biol. Chem. 2006) 2 3
  5. Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status. (PMID: 16434994) Fritzsche F. … Kristiansen G. (Br. J. Cancer 2006) 3 23

Products for KLK14 Gene

Sources for KLK14 Gene

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