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KLK13 Gene

protein-coding   GIFtS: 62
GCID: GC19M051559

Kallikrein-Related Peptidase 13

(Previous name: kallikrein 13)
  See KLK13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 131 2     kallikrein-132
KLKL42 3 5     Kallikrein-Like Gene 42
Kallikrein 131 2     EC 3.4.21.-3
Kallikrein-Like Protein 42 3     EC 3.4.218
KLK-L42 3     

External Ids:    HGNC: 63611   Entrez Gene: 260852   Ensembl: ENSG000001677597   OMIM: 6055055   UniProtKB: Q9UKR33   

Export aliases for KLK13 gene to outside databases

Previous GC identifers: GC19M052189 GC19M051920 GC19M056235 GC19M056251 GC19M047892


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK13 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An
additional transcript variant has been identified, but its full length sequence has not been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for KLK13 Gene:
KLK13 (kallikrein-related peptidase 13) is a protein-coding gene. Diseases associated with KLK13 include breast cancer, and ovarian cancer. GO annotations related to this gene include hydrolase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

Gene Wiki entry for KLK13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK13 gene promoter:
         C/EBPbeta   RREB-1   MyoD   AP-2gamma   AREB6   AP-2beta   Pax-4a   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK13 promoter sequence
   Search Chromatin IP Primers for KLK13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK13 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051559:  view genomic region     (about GC identifiers)

Start:
51,559,463 bp from pter      End:
51,568,371 bp from pter
Size:
8,909 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLK13_HUMAN, Q9UKR3 (See protein sequence)
Recommended Name: Kallikrein-13 precursor  
Size: 277 amino acids; 30570 Da
Secondary accessions: A7UNK6 Q9Y433

Explore the universe of human proteins at neXtProt for KLK13: NX_Q9UKR3

Explore proteomics data for KLK13 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn30, Asn225
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KLK13 (Q9UKR3) (see all 6)
     GDSGGPL  EGGKDSC  CGGVLVH  VLTAAHC 


    See KLK13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056411.1  
    ENSEMBL proteins: 
     ENSP00000470931   ENSP00000365995   ENSP00000156476   ENSP00000472596   ENSP00000392640  
     ENSP00000470555   ENSP00000470245   ENSP00000334079   ENSP00000472248  
    Reactome Protein details: Q9UKR3

    KLK13 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
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    Novus Biologicals KLK13 Proteins
    Novus Biologicals KLK13 Lysates
    Sino Biological Recombinant Protein for KLK13
    Sino Biological Cell Lysate for KLK13
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    Cloud-Clone Corp. Proteins for KLK13

     
    Search eBioscience for Proteins for KLK13 

    KLK13 Antibody Products:

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    KLK13 Assay Products:

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    Search eBioscience for ELISAs for KLK13 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9UKR3

    ProtoNet protein and cluster: Q9UKR3

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK13_HUMAN, Q9UKR3
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with KLK13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004175endopeptidase activity ----
    GO:0004252serine-type endopeptidase activity NAS10766816
    GO:0005515protein binding IPI14687906
    GO:0016787hydrolase activity IDA14687906
         
    Find genes that share ontologies with KLK13           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KLK13:
     Decreased melanin production  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK13
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK13

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    GenScript: all cDNA clones in your preferred vector: KLK13 (NM_015596)
    Sino Biological Human cDNA Clone for KLK13
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK13

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK13_HUMAN, Q9UKR3: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10766816
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IDA12642628
    GO:0030141secretory granule IBA--

    Find genes that share ontologies with KLK13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK13 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    3Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    4MSP-RON Signaling
    MSP-RON Signaling


    Find genes that share SuperPaths with KLK13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK13
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway


    1 Reactome Pathway for KLK13
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK13
    Interactions:

        Search GeneGlobe Interaction Network for KLK13

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KLK13 (Q9UKR33 ENSP000001564764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINF2P086973, ENSP000003218534I2D: score=2 STRING: ENSP00000321853
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    A2MP010233, ENSP000003239294I2D: score=1 STRING: ENSP00000323929
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS10766816
    GO:0016485protein processing ----

    Find genes that share ontologies with KLK13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK13

    2 Novoseek inferred chemical compound relationships for KLK13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 56.1 3 15381110 (1), 14966091 (1), 14687906 (1)
    steroid 35.5 1 14966091 (1)



    Find genes that share compounds with KLK13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLK13 gene: 
    NM_015596.1  

    Unigene Cluster for KLK13:

    Kallikrein-related peptidase 13
    Hs.165296  [show with all ESTs]
    Unigene Representative Sequence: AY923172
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601975 ENST00000376799(uc002pvl.3) ENST00000156476(uc002pvn.3 uc010eon.3 uc002pvq.3 uc010eoo.3)
    ENST00000602090 ENST00000441527(uc002pvm.3 uc002pvo.3 uc002pvp.3 uc002pvr.3)
    ENST00000595793 ENST00000595547 ENST00000335422 ENST00000596955
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKLK13 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat KLK13
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLK13 (NM_015596)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK13
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      QuantiTect SYBR Green Assays in human, mouse, rat KLK13
      QuantiFast Probe-based Assays in human, mouse, rat KLK13

    Additional mRNA sequence: 

    AB108823.1 AB108824.1 AB451465.1 AL050220.1 AY923171.1 AY923172.1 AY923173.1 AY923174.1 
    AY923175.1 BC069334.1 BC069543.1 

    6 DOTS entries:

    DT.100741572  DT.65285181  DT.92422253  DT.121487859  DT.121487868  DT.99996047 

    Selected AceView cDNA sequences (see all 25):

    AB108824 NM_015596 AI889574 BX106071 AB108823 BQ027298 BC069334 AL050220 
    AA846771 AA399955 BC069543 AW243944 BE716310 AI002101 BE715189 AI032327 
    BF354061 BE716321 AA401397 AW189585 BE184351 BF354621 BF354651 BQ356844 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLK13 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c
    SP1:              -                             -     -                           
    SP2:              -                                                               
    SP3:              -     -                       -     -                           
    SP4:              -     -                             -                           
    SP5:              -     -                 -     -     -                           


    ECgene alternative splicing isoforms for KLK13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCAACCT
    KLK13 Expression
    About this image

    KLK13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.165296

    UniProtKB/Swiss-Prot: KLK13_HUMAN, Q9UKR3
    Tissue specificity: Expressed in prostate, breast, testis and salivary gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK13 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk131 , 5 kallikrein related-peptidase 131, 5 78.91(n)1
    79.27(a)1
      7 (28.26 cM)5
    6268341  NM_001039042.21  NP_001034131.21 
     437125675 


    ENSEMBL Gene Tree for KLK13 (if available)
    TreeFam Gene Tree for KLK13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK13 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK13 using alignment to 8 protein entries:     KLK13_HUMAN (see all proteins) (see all similar genes):
    PRSS46    KLK11    KLK8    KLK5    KLK9    C2
    CFB    KLK6    TMPRSS15    KLK7    KLK1    PRSS1
    KLK10    KLK15    PRSS3    APS    KLK3    DF

    Find genes that share paralogs with KLK13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK13 (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469818091,2
    --51559107(+) CAATAA/TAGTTC 1 -- ds50010--------
    rs27364361,2
    C,F,O,A,H--51559114(-) CTTGCC/GTGAAC 1 -- ds500117Minor allele frequency- N:0.00EA NA NS WA 1408
    rs1922931631,2
    --51559197(+) CAGAGA/GTGGGG 1 -- ds50010--------
    rs1840749851,2
    --51559198(+) AGAGGC/TGGGGT 1 -- ds50010--------
    rs1477064911,2
    --51559231(+) GTTGGA/GTTGGG 1 -- ds50010--------
    rs1423837531,2
    --51559239(+) GGGACA/TTCTGA 1 -- ds50010--------
    rs1463820371,2
    --51559271(+) ATGAAA/CTATTC 1 -- ds50010--------
    rs1389990171,2
    --51559311(+) ACAGAC/GGTACA 1 -- ds50010--------
    rs116706231,2
    C,F,H--51559316(+) GGTACA/TCAGAA 1 -- ds50015Minor allele frequency- T:0.00NS EA NA 422
    rs1494371181,2
    --51559342(+) AGATTG/TTGGGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KLK13 (51559463 - 51568371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLK13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv828585CNV Loss20364138
    esv34104CNV Loss18971310
    nsv819004CNV Gain19587683
    nsv524556CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK13
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605505    OMIM disorders: --

    2 diseases for KLK13:    
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    breast cancer    ovarian cancer


    Find genes that share disorders with KLK13           About GenesLikeMe

    2 Novoseek inferred disease relationships for KLK13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 36.7 1 15381110 (1)
    breast cancer 33.5 6 10766816 (2), 11986781 (2), 14966091 (1)

    Genetic Association Database (GAD): KLK13
    Human Genome Epidemiology (HuGE) Navigator: KLK13 (1 document)

    Export disorders for KLK13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK13 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with KLK13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. (PubMed id 10766816)1, 2, 9 Yousef G.M.... Diamandis E.P. (J. Biol. Chem. 2000)
    2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    3. Understanding the accuracy of statistical haplotype inference with sequence data of known phase. (PubMed id 17922479)1, 2 Andres A.M....Hixson J.E. (Genet. Epidemiol. 2007)
    4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (Biol. Chem. 2006)
    5. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (Biol. Chem. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer. (PubMed id 11986781)1, 9 Chang A....Diamandis E.P. (Br. J. Cancer 2002)
    9. Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer. (PubMed id 11848466)1, 9 Chang A.... Diamandis E.P. (Anticancer Res. 2001)
    10. Complex formation between human kallikrein 13 and serum protease inhibitors. (PubMed id 14687906)1, 9 Kapadia C....Diamandis E.P. ( international journal of clinical chemistry 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26085 HGNC: 6361 AceView: KLK13 Ensembl:ENSG00000167759 euGenes: HUgn26085
    ECgene: KLK13 H-InvDB: KLK13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK13 gene:
    Search GeneIP for patents involving KLK13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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