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Aliases for KLK13 Gene

Aliases for KLK13 Gene

  • Kallikrein-Related Peptidase 13 2 3
  • KLKL4 3 4 6
  • Kallikrein-Like Protein 4 3 4
  • Kallikrein 13 2 3
  • KLK-L4 3 4
  • Kallikrein-Like Gene 4 3
  • Kallikrein-13 3
  • EC 3.4.21.- 4
  • EC 3.4.21 64

External Ids for KLK13 Gene

Summaries for KLK13 Gene

Entrez Gene Summary for KLK13 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK13 Gene

KLK13 (Kallikrein-Related Peptidase 13) is a Protein Coding gene. Diseases associated with KLK13 include breast cancer. Among its related pathways are Collagen biosynthesis and modifying enzymes and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity and hydrolase activity. An important paralog of this gene is KLK12.

Gene Wiki entry for KLK13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK13 Gene

Genomics for KLK13 Gene

Genomic Location for KLK13 Gene

Start:
51,056,206 bp from pter
End:
51,065,114 bp from pter
Size:
8,909 bases
Orientation:
Minus strand

Genomic View for KLK13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK13 Gene

Regulatory Elements for KLK13 Gene

Proteins for KLK13 Gene

  • Protein details for KLK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKR3-KLK13_HUMAN
    Recommended name:
    Kallikrein-13
    Protein Accession:
    Q9UKR3
    Secondary Accessions:
    • A7UNK6
    • Q86VI8
    • Q9Y433

    Protein attributes for KLK13 Gene

    Size:
    277 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK13 Gene

Proteomics data for KLK13 Gene at MOPED

Selected DME Specific Peptides for KLK13 Gene

Post-translational modifications for KLK13 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn30 and Asn225

Other Protein References for KLK13 Gene

Domains for KLK13 Gene

Gene Families for KLK13 Gene

HGNC:
  • KLK :Kallikreins

UniProtKB/Swiss-Prot:

KLK13_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • Q9UKR3
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.:
    • Q9UKR3
genes like me logo Genes that share domains with KLK13: view

Function for KLK13 Gene

Enzyme Numbers (IUBMB) for KLK13 Gene

Gene Ontology (GO) - Molecular Function for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004175 endopeptidase activity --
GO:0004252 serine-type endopeptidase activity NAS 10766816
GO:0005515 protein binding IPI 14687906
GO:0016787 hydrolase activity IDA 14687906
genes like me logo Genes that share ontologies with KLK13: view

Phenotypes for KLK13 Gene

genes like me logo Genes that share phenotypes with KLK13: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLK13 Gene

Localization for KLK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK13 Gene COMPARTMENTS Subcellular localization image for KLK13 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10766816
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA 12642628
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KLK13: view

Pathways for KLK13 Gene

genes like me logo Genes that share pathways with KLK13: view

Interacting Proteins for KLK13 Gene

Gene Ontology (GO) - Biological Process for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10766816
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with KLK13: view

Compounds for KLK13 Gene

(2) Novoseek inferred chemical compound relationships for KLK13 Gene

Compound -log(P) Hits PubMed IDs
serine 56.1 3
steroid 35.5 1
genes like me logo Genes that share compounds with KLK13: view

Transcripts for KLK13 Gene

Unigene Clusters for KLK13 Gene

Kallikrein-related peptidase 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for KLK13 Gene

GeneLoc Exon Structure for
KLK13
ECgene alternative splicing isoforms for
KLK13

Expression for KLK13 Gene

mRNA expression in normal human tissues for KLK13 Gene

mRNA differential expression in normal tissues according to GTEx for KLK13 Gene

This gene is overexpressed in Esophagus - Mucosa (33.1), Vagina (6.2), Cervix - Ectocervix (6.2), and Minor Salivary Gland (5.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KLK13 Gene

SOURCE GeneReport for Unigene cluster for KLK13 Gene Hs.165296

mRNA Expression by UniProt/SwissProt for KLK13 Gene

Q9UKR3-KLK13_HUMAN
Tissue specificity: Expressed in prostate, breast, testis and salivary gland
genes like me logo Genes that share expressions with KLK13: view

Orthologs for KLK13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK13 36
  • 99.52 (n)
  • 99.64 (a)
KLK13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLK13 37
  • 80 (a)
OneToOne
LOC540297 36
  • 83.87 (n)
  • 80.87 (a)
dog
(Canis familiaris)
Mammalia KLK13 36
  • 86.4 (n)
  • 84.12 (a)
KLK13 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk13 36
  • 78.91 (n)
  • 79.27 (a)
Klk13 16
Klk13 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLK13 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk13 36
  • 78.79 (n)
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17239 38
  • 35 (a)
CG11911 38
  • 34 (a)
Species with no ortholog for KLK13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK13 Gene

ENSEMBL:
Gene Tree for KLK13 (if available)
TreeFam:
Gene Tree for KLK13 (if available)

Paralogs for KLK13 Gene

genes like me logo Genes that share paralogs with KLK13: view

Variants for KLK13 Gene

Sequence variations from dbSNP and Humsavar for KLK13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1080668 -- 51,062,913(+) AGCTC(A/C)GTGGT intron-variant
rs1080669 -- 51,063,011(+) TCAGA(C/T)GCTGA intron-variant
rs1404318 -- 51,062,974(-) tcatc(C/T)ctcta intron-variant
rs1404319 -- 51,062,940(-) ACCGA(C/T)AACTT intron-variant
rs1404320 -- 51,062,889(-) GCCCT(A/G)TAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK13 Gene

Variant ID Type Subtype PubMed ID
nsv828585 CNV Loss 20364138
nsv524556 CNV Gain 19592680
esv34104 CNV Loss 18971310
nsv819004 CNV Gain 19587683

Relevant External Links for KLK13 Gene

HapMap Linkage Disequilibrium report
KLK13

Disorders for KLK13 Gene

(1) MalaCards Diseases for KLK13 Gene

Search for KLK13 Gene in MalaCards »

(2) Novoseek inferred disease relationships for KLK13 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 36.7 1
breast cancer 33.5 5

Relevant External Links for KLK13

Genetic Association Database (GAD)
KLK13
Human Genome Epidemiology (HuGE) Navigator
KLK13
genes like me logo Genes that share disorders with KLK13: view

No data available for UniProtKB/Swiss-Prot for KLK13 Gene

Publications for KLK13 Gene

  1. Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. (PMID: 10766816) Yousef G.M. … Diamandis E.P. (J. Biol. Chem. 2000) 3 4 23
  2. Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer. (PMID: 11848466) Chang A. … Diamandis E.P. (Anticancer Res. 2001) 3 23
  3. Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer. (PMID: 11986781) Chang A. … Diamandis E.P. (Br. J. Cancer 2002) 3 23
  4. Human kallikrein 13 expression in normal tissues: an immunohistochemical study. (PMID: 12642628) Petraki C.D. … Diamandis E.P. (J. Histochem. Cytochem. 2003) 3 23
  5. Complex formation between human kallikrein 13 and serum protease inhibitors. (PMID: 14687906) Kapadia C. … Diamandis E.P. (Clin. Chim. Acta 2004) 3 23

Products for KLK13 Gene

Sources for KLK13 Gene

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