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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK12 Gene

protein-coding   GIFtS: 53
GCID: GC19M051532

Kallikrein-Related Peptidase 12

(Previous name: kallikrein 12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 121 2     KLK-L52 3
KLKL52 3 5     kallikrein-122
Kallikrein 121 2     EC 3.4.21.-3
Kallikrein-Like Protein 52 3     EC 3.4.218

External Ids:    HGNC: 63601   Entrez Gene: 438492   Ensembl: ENSG000001864747   OMIM: 6055395   UniProtKB: Q9UKR03   

Export aliases for KLK12 gene to outside databases

Previous GC identifers: GC19M052162 GC19M051893 GC19M056202 GC19M056224 GC19M047864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK12 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Alternate splicing of this gene results in three transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2008)

GeneCards Summary for KLK12 Gene: 
KLK12 (kallikrein-related peptidase 12) is a protein-coding gene. Diseases associated with KLK12 include eczema herpeticum, and eczema, and among its related super-pathways are Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

Gene Wiki entry for KLK12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK12 gene promoter:
         GR   ER-alpha   LCR-F1   GATA-1   PPAR-gamma1   ZID   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK12 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051532:  view genomic region     (about GC identifiers)

Start:
51,532,348 bp from pter      End:
51,538,486 bp from pter
Size:
6,139 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLK12_HUMAN, Q9UKR0 (See protein sequence)
Recommended Name: Kallikrein-12 precursor  
Size: 248 amino acids; 26734 Da
Subcellular location: Secreted
Secondary accessions: Q9UKR1 Q9UKR2
Alternative splicing: 3 isoforms:  Q9UKR0-1   Q9UKR0-2   Q9UKR0-3   

Explore the universe of human proteins at neXtProt for KLK12: NX_Q9UKR0

Explore proteomics data for KLK12 at MOPED 

4/6 DME Specific Peptides for KLK12 (Q9UKR0) (see all 6)
 GDSGGPL  VLTAAHC  SGGPLVC  WVLTAAH 

KLK12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KLK12 Protein Expression
REFSEQ proteins (3 alternative transcripts): 
NP_062544.1  NP_665901.1  NP_665902.1  

ENSEMBL proteins: 
 ENSP00000436458   ENSP00000434339   ENSP00000434604   ENSP00000436121   ENSP00000434036  
 ENSP00000250351   ENSP00000250352   ENSP00000324181  

Human Recombinant Protein Products for KLK12: 
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R&D Systems Recombinant & Natural Proteins for KLK12 (Kallikrein 12)
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Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for KLK12
OriGene Custom MassSpec 
OriGene Custom Protein Services for KLK12
GenScript Custom Purified and Recombinant Proteins Services for KLK12
Novus Biologicals KLK12 Protein
Novus Biologicals KLK12 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for KLK12 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS--
GO:0005615extracellular space NAS--

KLK12 for ontologies           About GeneDecksing



KLK12 Antibody Products: 
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R&D Systems Antibodies for KLK12 (Kallikrein 12)
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Novus Biologicals KLK12 Antibody
Abcam antibodies for KLK12
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LSBio Antibodies in human, mouse, rat for KLK12 

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Cloud-Clone Corp. ELISAs for KLK12 
Cloud-Clone Corp. CLIAs for KLK12


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KLK: Kallikreins

4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR009003 Trypsin-like_Pept_dom
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS

Graphical View of Domain Structure for InterPro Entry Q9UKR0

ProtoNet protein and cluster: Q9UKR0

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: KLK12_HUMAN, Q9UKR0
Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
Similarity: Contains 1 peptidase S1 domain


KLK12 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity NAS11054574
GO:0008233peptidase activity IDA--
GO:0008236serine-type peptidase activity IDA15300858
     
KLK12 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for KLK12:
 Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

     1 MGI phenotypic allele for Klk12 (no phenotypes)

KLK12 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Klk12tm1Lex for KLK12

   inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK12 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLK12

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK12 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK12 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK12
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SwitchGear 3'UTR luciferase reporter plasmidKLK12 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for KLK12
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of KLK12

Clone
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OriGene ORF clones in mouse, rat for KLK12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): KLK12 (NM_145894)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK12
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK12
Sirion Biotech Customized lentivirus for stable overexpression of KLK12 
                     Customized lentivirus expression plasmids for stable overexpression of KLK12 

Cell Line
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GenScript Custom overexpressing Cell Line Services for KLK12
Search LifeMap BioReagents cell lines for KLK12
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK12


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KLK12 About                                                                                                See pathways by source

SuperPathContained pathways About
1Collagen biosynthesis and modifying enzymes
Intrinsic Prothrombin Activation Pathway0.40
Blood Coagulation Cascade0.39
2MSP-RON Signaling
MSP-RON Signaling

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK12
    MSP-RON Signaling
Blood Coagulation Cascade
Intrinsic Prothrombin Activation Pathway


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLK12

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis NAS--

KLK12 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLK12

Search CenterWatch for drugs/clinical trials and news about KLK12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLK12 gene (3 alternative transcripts): 
NM_019598.2  NM_145894.1  NM_145895.1  

Unigene Cluster for KLK12:

Kallikrein-related peptidase 12
Hs.411572  [show with all ESTs]
Unigene Representative Sequence: BC035385
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000525263(uc002pvg.1) ENST00000530943(uc010ycr.1) ENST00000526824
ENST00000531374(uc010ycp.1) ENST00000529888 ENST00000250351 ENST00000250352(uc010ycq.1)
ENST00000319590(uc010ycs.1 uc002pvh.1 uc002pvi.1 uc002pvj.1)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK12
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLK12
SwitchGear 3'UTR luciferase reporter plasmidKLK12 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for KLK12
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK12
Clone
Products:
     
OriGene clones in human, mouse for KLK12 (see all 16)
OriGene ORF clones in mouse, rat for KLK12
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GenScript: all cDNA clones in your preferred vector (see all 3): KLK12 (NM_145894)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK12
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK12
Sirion Biotech Customized lentivirus for stable overexpression of KLK12 
                     Customized lentivirus expression plasmids for stable overexpression of KLK12 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for KLK12
OriGene qSTAR qPCR primer pairs in human, mouse for KLK12
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK12
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK12
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK12

Additional mRNA sequence: 

AY358524.1 BC035385.1 BC136341.1 BC143988.1 BC143990.1 BC143991.1 BX648580.1 

2 DOTS entries:

DT.91803658  DT.91982151 

10 AceView cDNA sequences:

NM_019598 BC035385 NM_145894 BX110362 NM_145895 AY358524 BX648580 AI394679 
BG721150 BG230967 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KLK12    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1:              -     -                       -     -                     
SP2:                                -                                       
SP3:                    -           -                                       
SP4:                                            -     -                     


ECgene alternative splicing isoforms for KLK12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLK12 expression in normal human tissues (normalized intensities)      KLK12 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KLK12 Expression
About this image


KLK12 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Epithelium (Uncategorized)    fully expand to see all 2 entries
         head and neck epithelial cells   
 
 Pancreas (Endocrine System)
         Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
 
 Oral Cavity (Gastrointestinal Tract)
         gingival epithelium   

See KLK12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLK12

SOURCE GeneReport for Unigene cluster: Hs.411572
    SABiosciences Custom PCR Arrays for KLK12
Primer
Products:
OriGene qPCR primer pairs and template standards for KLK12
OriGene qSTAR qPCR primer pairs in human, mouse for KLK12
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK12
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK12
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK12

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for KLK12 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Klk121 , 5 kallikrein related-peptidase 121, 5 75.3(n)1
70.45(a)1
  7 (28.26 cM)5
695111  NM_027097.11  NP_081373.11 
 437688975 


ENSEMBL Gene Tree for KLK12 (if available)
TreeFam Gene Tree for KLK12 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KLK12 gene
KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
KLK92  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
PRSS32  KLK82  KLK32  
18/78 SIMAP similar genes for KLK12 using alignment to 5 protein entries:     KLK12_HUMAN (see all proteins) (see all similar genes):
KLK9    KLK8    TRY8    KLK5    TRY6    KLK15
PRSS2    PRSS3    KLK7    KLK4    KLK11    PRSS1
KLK10    KLK14    KLK1    KLK6    KLK13    CFD

KLK12 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/203 SNPs in KLK12 are shown (see all 203)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs665101211,2
C--47872685(+) CTCTT-/CTTTTT 3 -- us2k10--------
rs730537911,2
C--47872685(+) TCTCTC/TTTTTT 3 -- us2k11Minor allele frequency- T:0.00NA 2
rs25694601,2
C,F,A--47872697(+) TTTCTT/GTGTAG 3 -- us2k113Minor allele frequency- G:0.31NA WA CSA EA 513
rs81117661,2
C,F,A,H--47872763(+) ACAAAA/CAATAA 3 -- us2k123Minor allele frequency- C:0.17NS EA NA CSA WA 2454
rs116692371,2
C,F,H--51533417(+) CAGTCC/GTCTCC 3 -- int113Minor allele frequency- N:0.00EA NS NA WA 856
rs359964551,2
C--51533488(+) CCCTC-/TTCTCT 3 -- int10--------
rs1436780011,2
C--51533576(+) CCTCC-/ATT/ATTAT
T
/ATTATTATT
ATTAT
9 -- cds10--------
rs1416625211,2
C--51533624(+) GTTTTA/GAGACA 3 -- int10--------
rs1881073091,2
--51533767(+) CCCCCA/GGCTAA 3 -- int10--------
rs1436937911,2
C--51533849(+) GATCCG/TCCCGC 3 -- int10--------

HapMap Linkage Disequilibrium report for KLK12 (51532348 - 51538486 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for KLK12:    About this table     
Variant IDTypeSubtypePubMed ID
nsv912291CNV Loss21882294


Human Gene Mutation Database (HGMD): KLK12
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing KLK12
DNA2.0 Custom Variant and Variant Library Synthesis for KLK12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605539    OMIM disorders: --

5 diseases for KLK12:    About MalaCards
eczema herpeticum    eczema    prostate cancer    prostatitis
breast cancer

1 disease from the University of Copenhagen DISEASES database for KLK12:
Eczema herpeticum

KLK12 for disorders           About GeneDecksing

Genetic Association Database (GAD): KLK12
Human Genome Epidemiology (HuGE) Navigator: KLK12 (2 documents)

Export disorders for KLK12 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KLK12 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with KLK12)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. (PubMed id 15300858)1, 4, 9 Shinmura K....Sugimura H. (2004)
  2. Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (2010)
  3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
  4. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)
  5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
  6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  7. The new human kallikrein gene family: implications in carcinogenesis. (PubMed id 10675891)1, 2 Diamandis E.P.... Obiezu C.V. (2000)
  8. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2 Gan L.... Wang K. (2000)
  9. Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PubMed id 10652563)1, 2 Yousef G.M.... Diamandis E.P. (1999)
  10. KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. (PubMed id 11056051)1, 9 Yousef G.M....Diamandis E.P. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
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  Query String
PubMed
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 43849 HGNC: 6360 AceView: KLK12 Ensembl:ENSG00000186474 euGenes: HUgn43849
ECgene: KLK12 H-InvDB: KLK12

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KLK12 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KLK12 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KLK12 gene:
Search GeneIP for patents involving KLK12

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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