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KLK12 Gene

protein-coding   GIFtS: 55
GCID: GC19M051532

Kallikrein-Related Peptidase 12

(Previous name: kallikrein 12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 121 2     KLK-L52 3
KLKL52 3 5     kallikrein-122
Kallikrein 121 2     EC 3.4.21.-3
Kallikrein-Like Protein 52 3     EC 3.4.218

External Ids:    HGNC: 63601   Entrez Gene: 438492   Ensembl: ENSG000001864747   OMIM: 6055395   UniProtKB: Q9UKR03   

Export aliases for KLK12 gene to outside databases

Previous GC identifers: GC19M052162 GC19M051893 GC19M056202 GC19M056224 GC19M047864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK12 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Alternate splicing of this gene results in three transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2008)

GeneCards Summary for KLK12 Gene:
KLK12 (kallikrein-related peptidase 12) is a protein-coding gene. Diseases associated with KLK12 include eczema herpeticum, and influenza. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

Gene Wiki entry for KLK12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK12 gene promoter:
         GR   ER-alpha   LCR-F1   GATA-1   PPAR-gamma1   ZID   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK12 promoter sequence
   Search Chromatin IP Primers for KLK12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051532:  view genomic region     (about GC identifiers)

Start:
51,532,348 bp from pter      End:
51,538,486 bp from pter
Size:
6,139 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLK12_HUMAN, Q9UKR0 (See protein sequence)
Recommended Name: Kallikrein-12 precursor  
Size: 248 amino acids; 26734 Da
Secondary accessions: Q9UKR1 Q9UKR2
Alternative splicing: 3 isoforms:  Q9UKR0-1   Q9UKR0-2   Q9UKR0-3   

Explore the universe of human proteins at neXtProt for KLK12: NX_Q9UKR0

Explore proteomics data for KLK12 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn24, Asn163
  • Selected DME Specific Peptides for KLK12 (Q9UKR0) (see all 6)
     GDSGGPL  VLTAAHC  SGGPLVC  WVLTAAH 


    See KLK12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_062544.1  NP_665901.1  NP_665902.1  

    ENSEMBL proteins: 
     ENSP00000436458   ENSP00000434339   ENSP00000434604   ENSP00000436121   ENSP00000434036  
     ENSP00000250351   ENSP00000250352   ENSP00000324181  

    KLK12 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for KLK12
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    Novus Biologicals KLK12 Protein
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    Cloud-Clone Corp. Proteins for KLK12

    KLK12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9UKR0

    ProtoNet protein and cluster: Q9UKR0

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK12_HUMAN, Q9UKR0
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS11054574
    GO:0008233peptidase activity IDA--
    GO:0008236serine-type peptidase activity IDA15300858
         
    KLK12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KLK12:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Klk12 (no phenotypes)

    KLK12 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Klk12tm1Lex for KLK12

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK12
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK12

    miRNA
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    miRTarBase miRNAs that target KLK12:
    hsa-mir-1 (MIRT023672)

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK12

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK12_HUMAN, Q9UKR0: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS--

    KLK12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK12 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK12
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK12
    Interactions:

        Search GeneGlobe Interaction Network for KLK12

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA--

    KLK12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLK12 gene (3 alternative transcripts): 
    NM_019598.2  NM_145894.1  NM_145895.1  

    Unigene Cluster for KLK12:

    Kallikrein-related peptidase 12
    Hs.411572  [show with all ESTs]
    Unigene Representative Sequence: BC035385
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525263(uc002pvg.1) ENST00000530943(uc010ycr.1) ENST00000526824
    ENST00000531374(uc010ycp.1) ENST00000529888 ENST00000250351 ENST00000250352(uc010ycq.1)
    ENST00000319590(uc010ycs.1 uc002pvh.1 uc002pvi.1 uc002pvj.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLK12 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLK12
    SwitchGear 3'UTR luciferase reporter plasmidKLK12 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): KLK12 (NM_145894)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK12
    Primer
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    OriGene qPCR primer pairs and template standards for KLK12
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      QuantiTect SYBR Green Assays in human, mouse, rat KLK12
      QuantiFast Probe-based Assays in human, mouse, rat KLK12

    Additional mRNA sequence: 

    AY358524.1 BC035385.1 BC136341.1 BC143988.1 BC143990.1 BC143991.1 BX648580.1 

    2 DOTS entries:

    DT.91803658  DT.91982151 

    10 AceView cDNA sequences:

    BC035385 NM_145895 AY358524 NM_145894 BX110362 NM_019598 AI394679 BX648580 
    BG721150 BG230967 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KLK12    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:              -     -                       -     -                     
    SP2:                                -                                       
    SP3:                    -           -                                       
    SP4:                                            -     -                     


    ECgene alternative splicing isoforms for KLK12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLK12 Expression
    About this image

    KLK12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411572
        Custom PCR Arrays for KLK12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLK12 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk121 , 5 kallikrein related-peptidase 121, 5 75.3(n)1
    70.45(a)1
      7 (28.26 cM)5
    695111  NM_027097.11  NP_081373.11 
     437688975 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    45(a)
    1 → many
    GL343276.1(1578128-1583778)


    ENSEMBL Gene Tree for KLK12 (if available)
    TreeFam Gene Tree for KLK12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK12 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK12 using alignment to 5 protein entries:     KLK12_HUMAN (see all proteins) (see all similar genes):
    KLK9    KLK8    TRY8    KLK5    KLK15    PRSS2
    PRSS3    KLK11    KLK7    KLK4    PRSS1    KLK10
    KLK14    KLK1    KLK6    KLK13    CFD    KLKB1

    KLK12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK12 (see all 203)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665101211,2
    C--47872685(+) CTCTT-/CTTTTT 3 -- us2k10--------
    rs730537911,2
    C--47872685(+) TCTCTC/TTTTTT 3 -- us2k11Minor allele frequency- T:0.00NA 2
    rs25694601,2
    C,F,A--47872697(+) TTTCTT/GTGTAG 3 -- us2k113Minor allele frequency- G:0.31NA WA CSA EA 513
    rs81117661,2
    C,F,A,H--47872763(+) ACAAAA/CAATAA 3 -- us2k123Minor allele frequency- C:0.17NS EA NA CSA WA 2454
    rs116692371,2
    C,F,H--51533417(+) CAGTCC/GTCTCC 3 -- int113Minor allele frequency- N:0.00EA NS NA WA 856
    rs359964551,2
    C--51533488(+) CCCTC-/TTCTCT 3 -- int10--------
    rs1436780011,2
    C--51533576(+) CCTCC-/ATT/ATTAT
    T
    /ATTATTATT
    ATTAT
    9 -- cds10--------
    rs1416625211,2
    C--51533624(+) GTTTTA/GAGACA 3 -- int10--------
    rs1881073091,2
    --51533767(+) CCCCCA/GGCTAA 3 -- int10--------
    rs1436937911,2
    C--51533849(+) GATCCG/TCCCGC 3 -- int10--------

    HapMap Linkage Disequilibrium report for KLK12 (51532348 - 51538486 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KLK12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912291CNV Loss21882294

    Human Gene Mutation Database (HGMD): KLK12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK12
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605539    OMIM disorders: --

    6 diseases for KLK12:    
    About MalaCards
    eczema herpeticum    influenza    prostate cancer    prostatitis
    breast cancer    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for KLK12:
    Eczema herpeticum

    KLK12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLK12
    Human Genome Epidemiology (HuGE) Navigator: KLK12 (2 documents)

    Export disorders for KLK12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK12 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with KLK12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. (PubMed id 15300858)1, 4, 9 Shinmura K....Sugimura H. (Hum. Mutat. 2004)
    2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (Biol. Chem. 2006)
    4. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (Biol. Chem. 2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. The new human kallikrein gene family: implications in carcinogenesis. (PubMed id 10675891)1, 2 Diamandis E.P.... Obiezu C.V. (Trends Endocrinol. Metab. 2000)
    8. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2 Gan L.... Wang K. (Gene 2000)
    9. Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PubMed id 10652563)1, 2 Yousef G.M.... Diamandis E.P. (Anticancer Res. 1999)
    10. KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. (PubMed id 11056051)1, 9 Yousef G.M....Diamandis E.P. (Genomics 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 43849 HGNC: 6360 AceView: KLK12 Ensembl:ENSG00000186474 euGenes: HUgn43849
    ECgene: KLK12 H-InvDB: KLK12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK12 gene:
    Search GeneIP for patents involving KLK12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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