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Aliases for KLK12 Gene

Aliases for KLK12 Gene

  • Kallikrein-Related Peptidase 12 2 3
  • Kallikrein-Like Protein 5 3 4
  • Kallikrein 12 2 3
  • KLK-L5 3 4
  • KLKL5 3 4
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for KLK12 Gene

Previous GeneCards Identifiers for KLK12 Gene

  • GC19M052162
  • GC19M051893
  • GC19M056202
  • GC19M056224
  • GC19M051532
  • GC19M047864

Summaries for KLK12 Gene

Entrez Gene Summary for KLK12 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK12 Gene

KLK12 (Kallikrein-Related Peptidase 12) is a Protein Coding gene. Diseases associated with KLK12 include eczema herpeticum. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK14.

Gene Wiki entry for KLK12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK12 Gene

Genomics for KLK12 Gene

Regulatory Elements for KLK12 Gene

Genomic Location for KLK12 Gene

Chromosome:
19
Start:
51,028,960 bp from pter
End:
51,035,652 bp from pter
Size:
6,693 bases
Orientation:
Minus strand

Genomic View for KLK12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK12 Gene

Proteins for KLK12 Gene

  • Protein details for KLK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKR0-KLK12_HUMAN
    Recommended name:
    Kallikrein-12
    Protein Accession:
    Q9UKR0
    Secondary Accessions:
    • Q9UKR1
    • Q9UKR2

    Protein attributes for KLK12 Gene

    Size:
    248 amino acids
    Molecular mass:
    26734 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK12 Gene

Proteomics data for KLK12 Gene at MOPED

Selected DME Specific Peptides for KLK12 Gene

Post-translational modifications for KLK12 Gene

  • Glycosylation at Asn 24 and Asn 163
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK12 (Kallikrein 12)
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLK12

Domains & Families for KLK12 Gene

Gene Families for KLK12 Gene

Suggested Antigen Peptide Sequences for KLK12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKR0

UniProtKB/Swiss-Prot:

KLK12_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK12: view

Function for KLK12 Gene

Enzyme Numbers (IUBMB) for KLK12 Gene

Gene Ontology (GO) - Molecular Function for KLK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11054574
GO:0008233 peptidase activity IDA 21628462
GO:0008236 serine-type peptidase activity IDA 15300858
genes like me logo Genes that share ontologies with KLK12: view
genes like me logo Genes that share phenotypes with KLK12: view

Animal Model Products

miRNA for KLK12 Gene

miRTarBase miRNAs that target KLK12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK12 Gene

Localization for KLK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK12 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK12 Gene COMPARTMENTS Subcellular localization image for KLK12 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for KLK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 21628462
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KLK12: view

Pathways & Interactions for KLK12 Gene

genes like me logo Genes that share pathways with KLK12: view

Pathways by source for KLK12 Gene

Interacting Proteins for KLK12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000250351%0d%0a9606.ENSP00000333837%0d%0a
Selected Interacting proteins: ENSP00000250351 for KLK12 Gene via STRING

Symbol External ID(s) Details
MRPL12

Gene Ontology (GO) - Biological Process for KLK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 21628462
genes like me logo Genes that share ontologies with KLK12: view

No data available for SIGNOR curated interactions for KLK12 Gene

Drugs & Compounds for KLK12 Gene

No Compound Related Data Available

Transcripts for KLK12 Gene

mRNA/cDNA for KLK12 Gene

Unigene Clusters for KLK12 Gene

Kallikrein-related peptidase 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for KLK12 Gene

GeneLoc Exon Structure for
KLK12
ECgene alternative splicing isoforms for
KLK12

Expression for KLK12 Gene

mRNA expression in normal human tissues for KLK12 Gene

mRNA differential expression in normal tissues according to GTEx for KLK12 Gene

This gene is overexpressed in Esophagus - Mucosa (x26.8), Cervix - Ectocervix (x12.8), Vagina (x6.8), and Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for KLK12 Gene

This gene is overexpressed in Saliva (52.9) and Salivary gland (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK12 Gene



SOURCE GeneReport for Unigene cluster for KLK12 Gene Hs.411572

genes like me logo Genes that share expression patterns with KLK12: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLK12 Gene

Orthologs for KLK12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK12 35
  • 82.39 (n)
  • 78.63 (a)
KLK12 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK12 35
  • 81.72 (n)
  • 77.02 (a)
-- 36
  • 25 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Klk12 35
  • 75.3 (n)
  • 70.45 (a)
Klk12 16
Klk12 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLK12 35
  • 98.45 (n)
  • 98.31 (a)
KLK12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk12 35
  • 73.37 (n)
  • 70.39 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
Species with no ortholog for KLK12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK12 Gene

ENSEMBL:
Gene Tree for KLK12 (if available)
TreeFam:
Gene Tree for KLK12 (if available)

Paralogs for KLK12 Gene

genes like me logo Genes that share paralogs with KLK12: view

Variants for KLK12 Gene

Sequence variations from dbSNP and Humsavar for KLK12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1997014 -- 51,031,361(-) CTGGC(A/G)TTGGA intron-variant
rs2569458 -- 51,036,070(+) GAGGA(A/G)GGGGG upstream-variant-2KB
rs2569459 -- 51,036,176(+) CTTGA(C/T)GCCAG upstream-variant-2KB
rs2569460 -- 51,036,905(+) TTTCT(G/T)TGTAG upstream-variant-2KB
rs2691210 -- 51,033,386(+) CAAGA(C/T)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK12 Gene

Variant ID Type Subtype PubMed ID
nsv912291 CNV Loss 21882294

Variation tolerance for KLK12 Gene

Residual Variation Intolerance Score: 70.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK12 Gene

HapMap Linkage Disequilibrium report
KLK12
Human Gene Mutation Database (HGMD)
KLK12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK12 Gene

Disorders for KLK12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLK12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
eczema herpeticum
  • herpes simplex dermatitis
- elite association
Search KLK12 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK12

Genetic Association Database (GAD)
KLK12
Human Genome Epidemiology (HuGE) Navigator
KLK12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK12
genes like me logo Genes that share disorders with KLK12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK12 Gene

Publications for KLK12 Gene

  1. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 67
  2. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A. … Yousef G.M. (Biol. Chem. 2006) 2 67
  3. Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. (PMID: 15300858) Shinmura K. … Sugimura H. (Hum. Mutat. 2004) 23 67
  4. KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. (PMID: 11056051) Yousef G.M. … Diamandis E.P. (Genomics 2000) 23 67
  5. Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12. (PMID: 23612974) Hamilton B.S. … Whittaker G.R. (J. Biol. Chem. 2013) 67

Products for KLK12 Gene

Sources for KLK12 Gene

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