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Aliases for KLK11 Gene

Aliases for KLK11 Gene

  • Kallikrein-Related Peptidase 11 2 3
  • PRSS20 3 4 6
  • TLSP 3 4 6
  • Trypsin-Like Protease 3 4
  • Serine Protease 20 3 4
  • Kallikrein 11 2 3
  • Hippostasin 3 4
  • HK11 3 4
  • Kallikrein-11 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for KLK11 Gene

Previous HGNC Symbols for KLK11 Gene

  • PRSS20

Previous GeneCards Identifiers for KLK11 Gene

  • GC19M052155
  • GC19M051886
  • GC19M056201
  • GC19M056217
  • GC19M051525
  • GC19M047858

Summaries for KLK11 Gene

Entrez Gene Summary for KLK11 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]

GeneCards Summary for KLK11 Gene

KLK11 (Kallikrein-Related Peptidase 11) is a Protein Coding gene. Diseases associated with KLK11 include prostate cancer. Among its related pathways are Collagen biosynthesis and modifying enzymes and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK11 Gene

  • Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Gene Wiki entry for KLK11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK11 Gene

Genomics for KLK11 Gene

Regulatory Elements for KLK11 Gene

Genomic Location for KLK11 Gene

Start:
51,022,216 bp from pter
End:
51,028,039 bp from pter
Size:
5,824 bases
Orientation:
Minus strand

Genomic View for KLK11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK11 Gene

Proteins for KLK11 Gene

  • Protein details for KLK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBX7-KLK11_HUMAN
    Recommended name:
    Kallikrein-11
    Protein Accession:
    Q9UBX7
    Secondary Accessions:
    • O75837
    • Q0WXX5
    • Q8IXD7
    • Q9NS65

    Protein attributes for KLK11 Gene

    Size:
    282 amino acids
    Molecular mass:
    31059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK11 Gene

Proteomics data for KLK11 Gene at MOPED

Selected DME Specific Peptides for KLK11 Gene

Post-translational modifications for KLK11 Gene

  • About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
  • Glycosylation at Asn99, Asn165, Asn181, and Asn210
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK11 (Kallikrein 11)

Domains for KLK11 Gene

Gene Families for KLK11 Gene

HGNC:
  • KLK :Kallikreins
  • PRSS :Serine peptidases / Serine peptidases

Suggested Antigen Peptide Sequences for KLK11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBX7

UniProtKB/Swiss-Prot:

KLK11_HUMAN :
  • Q9UBX7
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK11: view

Function for KLK11 Gene

Molecular function for KLK11 Gene

UniProtKB/Swiss-Prot Function: Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Enzyme Numbers (IUBMB) for KLK11 Gene

Gene Ontology (GO) - Molecular Function for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 9765601
genes like me logo Genes that share ontologies with KLK11: view

Animal Model Products

CRISPR Products

miRNA for KLK11 Gene

miRTarBase miRNAs that target KLK11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK11

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLK11 Gene

Localization for KLK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK11 Gene

Isoform 1: Secreted.
Isoform 2: Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK11 Gene COMPARTMENTS Subcellular localization image for KLK11 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KLK11: view

Pathways for KLK11 Gene

genes like me logo Genes that share pathways with KLK11: view

Pathways by source for KLK11 Gene

Interacting Proteins for KLK11 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000473047%0d%0a9606.ENSP00000348170%0d%0a9606.ENSP00000441828%0d%0a
Selected Interacting proteins: ENSP00000473047 for KLK11 Gene via STRING

Gene Ontology (GO) - Biological Process for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK11: view

Compounds for KLK11 Gene

(27) Novoseek inferred chemical compound relationships for KLK11 Gene

Compound -log(P) Hits PubMed IDs
serine 86 125
babim 76.7 1
tlck 76.6 8
leupeptin 74.2 4
benzamidine 73.9 1
genes like me logo Genes that share compounds with KLK11: view

Transcripts for KLK11 Gene

Unigene Clusters for KLK11 Gene

Kallikrein-related peptidase 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7: - - - - - -
SP8: -

Relevant External Links for KLK11 Gene

GeneLoc Exon Structure for
KLK11
ECgene alternative splicing isoforms for
KLK11

Expression for KLK11 Gene

mRNA expression in normal human tissues for KLK11 Gene

mRNA differential expression in normal tissues according to GTEx for KLK11 Gene

This gene is overexpressed in Esophagus - Mucosa (11.7), Skin - Sun Exposed (Lower leg) (9.0), Skin - Not Sun Exposed (Suprapubic) (7.3), Vagina (5.9), Minor Salivary Gland (5.0), and Cervix - Ectocervix (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KLK11 Gene

SOURCE GeneReport for Unigene cluster for KLK11 Gene Hs.57771

mRNA Expression by UniProt/SwissProt for KLK11 Gene

Q9UBX7-KLK11_HUMAN
Tissue specificity: Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
genes like me logo Genes that share expressions with KLK11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KLK11 Gene

Orthologs for KLK11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK11 35
  • 98.82 (n)
  • 97.52 (a)
KLK11 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLK11 35
  • 85.87 (n)
  • 81.6 (a)
KLK11 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK11 35
  • 85.73 (n)
  • 82 (a)
KLK11 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk11 35
  • 82.97 (n)
  • 78.62 (a)
Klk11 16
Klk11 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLK11 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk11 35
  • 82.97 (n)
  • 79.86 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485189 35
  • 55.01 (n)
  • 50.67 (a)
Species with no ortholog for KLK11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK11 Gene

ENSEMBL:
Gene Tree for KLK11 (if available)
TreeFam:
Gene Tree for KLK11 (if available)

Paralogs for KLK11 Gene

Pseudogenes.org Pseudogenes for KLK11 Gene

genes like me logo Genes that share paralogs with KLK11: view

Variants for KLK11 Gene

Sequence variations from dbSNP and Humsavar for KLK11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1048328 - 51,024,108(-) CCTCA(C/T)GCTGT reference, missense, intron-variant
rs1048344 -- 51,022,447(-) CCTCT(A/G)CGAAC utr-variant-3-prime
rs1474520 -- 51,027,437(-) GGACT(C/T)GGGCT upstream-variant-2KB, intron-variant
rs2250066 -- 51,025,863(+) GTGGC(C/T)TTGGA intron-variant
rs2288892 - 51,025,634(+) CATGG(C/T)CTGGA utr-variant-5-prime, missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KLK11 Gene

Variant ID Type Subtype PubMed ID
nsv912291 CNV Loss 21882294

Relevant External Links for KLK11 Gene

HapMap Linkage Disequilibrium report
KLK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK11 Gene

Disorders for KLK11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KLK11 Gene including...

Search for KLK11 Gene in MalaCards »

(17) Novoseek inferred disease relationships for KLK11 Gene

Disease -log(P) Hits PubMed IDs
airways disease 35.3 4
prostate cancer 26.9 16
periodontal diseases 21.6 1
metastasis 1.28 5
cancer 1.14 8

Relevant External Links for KLK11

Genetic Association Database (GAD)
KLK11
Human Genome Epidemiology (HuGE) Navigator
KLK11
genes like me logo Genes that share disorders with KLK11: view

No data available for UniProtKB/Swiss-Prot for KLK11 Gene

Publications for KLK11 Gene

  1. Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. (PMID: 10662548) Yousef G.M. … Diamandis E.P. (Genomics 2000) 2 3 4 23
  2. A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. (PMID: 10872828) Mitsui S. … Yamaguchi N. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  3. Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. (PMID: 12845660) BorgoA+o C.A. … Katsaros D. (Int. J. Cancer 2003) 3 23 48
  4. Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. (PMID: 16911518) Mitsui S. … Yamaguchi N. (FEBS J. 2006) 3 4 23
  5. cDNA cloning and expression of a novel serine protease, TLSP. (PMID: 9765601) Yoshida S. … Shiosaka S. (Biochim. Biophys. Acta 1998) 2 3 4

Products for KLK11 Gene

Sources for KLK11 Gene

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