Aliases for KLK11 Gene
External Ids for KLK11 Gene
Previous HGNC Symbols for KLK11 Gene
Previous GeneCards Identifiers for KLK11 Gene
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]
GeneCards Summary for KLK11 Gene
KLK11 (Kallikrein-Related Peptidase 11) is a Protein Coding gene. Diseases associated with KLK11 include prostate cancer. Among its related pathways are Collagen biosynthesis and modifying enzymes and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.
UniProtKB/Swiss-Prot for KLK11 Gene
Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.