Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLK11 Gene

Aliases for KLK11 Gene

  • Kallikrein Related Peptidase 11 2 3 5
  • Trypsin-Like Protease 3 4
  • Serine Protease 20 3 4
  • Kallikrein 11 2 3
  • Hippostasin 3 4
  • PRSS20 3 4
  • TLSP 3 4
  • HK11 3 4
  • Kallikrein-Related Peptidase 11 3
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for KLK11 Gene

Previous HGNC Symbols for KLK11 Gene

  • PRSS20

Previous GeneCards Identifiers for KLK11 Gene

  • GC19M052155
  • GC19M051886
  • GC19M056201
  • GC19M056217
  • GC19M051525
  • GC19M047858

Summaries for KLK11 Gene

Entrez Gene Summary for KLK11 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]

GeneCards Summary for KLK11 Gene

KLK11 (Kallikrein Related Peptidase 11) is a Protein Coding gene. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK11 Gene

  • Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Gene Wiki entry for KLK11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK11 Gene

Genomics for KLK11 Gene

Regulatory Elements for KLK11 Gene

Enhancers for KLK11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLK11 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK11 Gene

51,022,216 bp from pter
51,028,039 bp from pter
5,824 bases
Minus strand

Genomic View for KLK11 Gene

Genes around KLK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK11 Gene

Proteins for KLK11 Gene

  • Protein details for KLK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75837
    • Q0WXX5
    • Q8IXD7
    • Q9NS65

    Protein attributes for KLK11 Gene

    282 amino acids
    Molecular mass:
    31059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK11 Gene


neXtProt entry for KLK11 Gene

Proteomics data for KLK11 Gene at MOPED

Selected DME Specific Peptides for KLK11 Gene

Post-translational modifications for KLK11 Gene

  • About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
  • Glycosylation at Asn 99, Asn 165, Asn 181, and Asn 210
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK11 (Kallikrein 11)

Domains & Families for KLK11 Gene

Gene Families for KLK11 Gene

Suggested Antigen Peptide Sequences for KLK11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK11: view

Function for KLK11 Gene

Molecular function for KLK11 Gene

UniProtKB/Swiss-Prot Function:
Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Enzyme Numbers (IUBMB) for KLK11 Gene

genes like me logo Genes that share phenotypes with KLK11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK11

miRNA for KLK11 Gene

miRTarBase miRNAs that target KLK11

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK11 Gene

Localization for KLK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK11 Gene

Isoform 1: Secreted.
Isoform 2: Golgi apparatus.

Subcellular locations from

Jensen Localization Image for KLK11 Gene COMPARTMENTS Subcellular localization image for KLK11 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
cytosol 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK11: view

Pathways & Interactions for KLK11 Gene

genes like me logo Genes that share pathways with KLK11: view

Pathways by source for KLK11 Gene

Interacting Proteins for KLK11 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000473047 for KLK11 Gene via STRING

Gene Ontology (GO) - Biological Process for KLK11 Gene


No data available for SIGNOR curated interactions for KLK11 Gene

Drugs & Compounds for KLK11 Gene

(13) Drugs for KLK11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for KLK11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK11: view

Transcripts for KLK11 Gene

Unigene Clusters for KLK11 Gene

Kallikrein-related peptidase 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP6: - -
SP7: - - - - - -
SP8: -

Relevant External Links for KLK11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK11 Gene

mRNA expression in normal human tissues for KLK11 Gene

mRNA differential expression in normal tissues according to GTEx for KLK11 Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Skin - Sun Exposed (Lower leg) (x9.0), Skin - Not Sun Exposed (Suprapubic) (x7.3), Vagina (x5.9), Minor Salivary Gland (x5.0), and Cervix - Ectocervix (x4.2).

Protein differential expression in normal tissues from HIPED for KLK11 Gene

This gene is overexpressed in Cervix (40.6), Oral epithelium (8.2), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK11 Gene

SOURCE GeneReport for Unigene cluster for KLK11 Gene Hs.57771

mRNA Expression by UniProt/SwissProt for KLK11 Gene

Tissue specificity: Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
genes like me logo Genes that share expression patterns with KLK11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for KLK11 Gene

Orthologs for KLK11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLK11 35
  • 85.87 (n)
  • 81.6 (a)
KLK11 36
  • 74 (a)
(Canis familiaris)
Mammalia KLK11 35
  • 85.73 (n)
  • 82 (a)
KLK11 36
  • 78 (a)
(Mus musculus)
Mammalia Klk11 35
  • 82.97 (n)
  • 78.62 (a)
Klk11 16
Klk11 36
  • 78 (a)
(Pan troglodytes)
Mammalia KLK11 35
  • 98.82 (n)
  • 97.52 (a)
KLK11 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Klk11 35
  • 82.97 (n)
  • 79.86 (a)
(Monodelphis domestica)
Mammalia KLK11 36
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485189 35
  • 55.01 (n)
  • 50.67 (a)
Species with no ortholog for KLK11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK11 Gene

Gene Tree for KLK11 (if available)
Gene Tree for KLK11 (if available)

Paralogs for KLK11 Gene Pseudogenes for KLK11 Gene

genes like me logo Genes that share paralogs with KLK11: view

Variants for KLK11 Gene

Sequence variations from dbSNP and Humsavar for KLK11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745539 - 51,024,785(+) CTCCC(A/C/T)CTACA intron-variant, reference, missense
rs1048328 - 51,024,108(-) CCTCA(C/T)GCTGT intron-variant, reference, missense
rs2288892 - 51,025,634(+) CATGG(C/T)CTGGA reference, missense, utr-variant-5-prime
rs12979919 -- 51,022,779(+) GCTTA(A/G)GAGTG intron-variant
rs1048344 -- 51,022,447(-) CCTCT(A/G)CGAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLK11 Gene

Variant ID Type Subtype PubMed ID
nsv912291 CNV Loss 21882294

Variation tolerance for KLK11 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLK11 Gene

Disorders for KLK11 Gene

Relevant External Links for KLK11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLK11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK11 Gene

Publications for KLK11 Gene

  1. Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. (PMID: 10662548) Yousef G.M. … Diamandis E.P. (Genomics 2000) 2 3 4 23 67
  2. Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer. (PMID: 19242826) Bi X. … Zhong W. (Med. Oncol. 2010) 3 23
  3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 3
  4. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A. … Yousef G.M. (Biol. Chem. 2006) 2 3
  5. Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. (PMID: 16911518) Mitsui S. … Yamaguchi N. (FEBS J. 2006) 3 23

Products for KLK11 Gene

Sources for KLK11 Gene