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Aliases for KLK11 Gene

Aliases for KLK11 Gene

  • Kallikrein Related Peptidase 11 2 3 5
  • Trypsin-Like Protease 3 4
  • Serine Protease 20 3 4
  • Hippostasin 3 4
  • PRSS20 3 4
  • TLSP 3 4
  • HK11 3 4
  • Kallikrein 11 2
  • Kallikrein-11 3
  • EC 3.4.21.4 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for KLK11 Gene

Previous HGNC Symbols for KLK11 Gene

  • PRSS20

Previous GeneCards Identifiers for KLK11 Gene

  • GC19M052155
  • GC19M051886
  • GC19M056201
  • GC19M056217
  • GC19M051525
  • GC19M047858

Summaries for KLK11 Gene

Entrez Gene Summary for KLK11 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]

GeneCards Summary for KLK11 Gene

KLK11 (Kallikrein Related Peptidase 11) is a Protein Coding gene. Diseases associated with KLK11 include Fusariosis. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK9.

UniProtKB/Swiss-Prot for KLK11 Gene

  • Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Gene Wiki entry for KLK11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK11 Gene

Genomics for KLK11 Gene

Regulatory Elements for KLK11 Gene

Enhancers for KLK11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051070 0.2 ENCODE 10.9 -43.1 -43089 1.0 PKNOX1 DPF2 ZNF217 ARID3A CTBP1 JUND GATA3 NCOR1 RCOR1 CUX1 POLD1 CTU1 KLK10 KLK11 KLK2 KLK13 KLK14
GH19F050896 0.5 Ensembl ENCODE 10 +130.9 130939 1.8 HDGF PKNOX1 ATF1 GLIS2 ZNF143 FOS SP3 JUNB NCOA1 TSHZ1 NUP62 ZNF175 KLK2 LINC01869 KLK15 KLK1 ZNF577 KLK11 POLD1 CTU1
GH19F050759 0.9 ENCODE 9.6 +268.0 267991 0.2 ATF1 CBX3 ARNT TBL1XR1 CREB3L1 ZNF76 ZNF143 FOS CREM THAP11 SNORD88C LINC01869 C19orf48 KLK11 GPR32P1 GPR32
GH19F051121 1.3 FANTOM5 Ensembl ENCODE 5.3 -99.5 -99508 11.7 PKNOX1 ATF1 YBX1 YY1 GATA2 ELK1 FOS JUNB NCOA1 REST SIGLEC9 SIGLEC18P SIGLEC10 C19orf81 SIGLEC17P KLK11 SIGLEC7 CD33 SIGLEC12 ENSG00000267990
GH19F051025 0.5 ENCODE 0.8 +1.3 1340 2.5 MTA3 MCM3 PKNOX1 ZNF223 ZBTB33 MNT MGA KLK12 KLK11 KLK10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KLK11 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK11 Gene

Chromosome:
19
Start:
51,022,216 bp from pter
End:
51,028,039 bp from pter
Size:
5,824 bases
Orientation:
Minus strand

Genomic View for KLK11 Gene

Genes around KLK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK11 Gene

Proteins for KLK11 Gene

  • Protein details for KLK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBX7-KLK11_HUMAN
    Recommended name:
    Kallikrein-11
    Protein Accession:
    Q9UBX7
    Secondary Accessions:
    • O75837
    • Q0WXX5
    • Q8IXD7
    • Q9NS65

    Protein attributes for KLK11 Gene

    Size:
    282 amino acids
    Molecular mass:
    31059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK11 Gene

Selected DME Specific Peptides for KLK11 Gene

Post-translational modifications for KLK11 Gene

  • About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
  • Glycosylation at Asn 99, Asn 165, Asn 181, and Asn 210
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK11 (Kallikrein 11)
  • Cloud-Clone Corp. Antibodies for KLK11
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLK11

Domains & Families for KLK11 Gene

Gene Families for KLK11 Gene

Suggested Antigen Peptide Sequences for KLK11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBX7

UniProtKB/Swiss-Prot:

KLK11_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK11: view

Function for KLK11 Gene

Molecular function for KLK11 Gene

UniProtKB/Swiss-Prot Function:
Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Enzyme Numbers (IUBMB) for KLK11 Gene

Gene Ontology (GO) - Molecular Function for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 9765601
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK11: view
genes like me logo Genes that share phenotypes with KLK11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK11

miRNA for KLK11 Gene

miRTarBase miRNAs that target KLK11

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK11 Gene

Localization for KLK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK11 Gene

Isoform 1: Secreted.
Isoform 2: Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK11 Gene COMPARTMENTS Subcellular localization image for KLK11 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
cytosol 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KLK11: view

Pathways & Interactions for KLK11 Gene

genes like me logo Genes that share pathways with KLK11: view

Pathways by source for KLK11 Gene

Interacting Proteins for KLK11 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000473047%0d%0a9606.ENSP00000348170%0d%0a9606.ENSP00000441828%0d%0a
Selected Interacting proteins: ENSP00000473047 Q9UBX7-KLK11_HUMAN for KLK11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK11: view

No data available for SIGNOR curated interactions for KLK11 Gene

Drugs & Compounds for KLK11 Gene

(13) Drugs for KLK11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for KLK11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK11: view

Transcripts for KLK11 Gene

Unigene Clusters for KLK11 Gene

Kallikrein-related peptidase 11:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7: - - - - - -
SP8: -

Relevant External Links for KLK11 Gene

GeneLoc Exon Structure for
KLK11
ECgene alternative splicing isoforms for
KLK11

Expression for KLK11 Gene

mRNA expression in normal human tissues for KLK11 Gene

mRNA differential expression in normal tissues according to GTEx for KLK11 Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Skin - Sun Exposed (Lower leg) (x9.0), Skin - Not Sun Exposed (Suprapubic) (x7.3), Vagina (x5.9), Minor Salivary Gland (x5.0), and Cervix - Ectocervix (x4.2).

Protein differential expression in normal tissues from HIPED for KLK11 Gene

This gene is overexpressed in Cervix (40.6), Oral epithelium (8.2), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK11 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLK11 Gene:

KLK11

SOURCE GeneReport for Unigene cluster for KLK11 Gene:

Hs.57771

mRNA Expression by UniProt/SwissProt for KLK11 Gene:

Q9UBX7-KLK11_HUMAN
Tissue specificity: Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
genes like me logo Genes that share expression patterns with KLK11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for KLK11 Gene

Orthologs for KLK11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK11 34 35
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia KLK11 34 35
  • 85.87 (n)
dog
(Canis familiaris)
Mammalia KLK11 34 35
  • 85.73 (n)
mouse
(Mus musculus)
Mammalia Klk11 34 16 35
  • 82.97 (n)
rat
(Rattus norvegicus)
Mammalia Klk11 34
  • 82.97 (n)
oppossum
(Monodelphis domestica)
Mammalia KLK11 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485189 34
  • 55.01 (n)
Species where no ortholog for KLK11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK11 Gene

ENSEMBL:
Gene Tree for KLK11 (if available)
TreeFam:
Gene Tree for KLK11 (if available)

Paralogs for KLK11 Gene

Pseudogenes.org Pseudogenes for KLK11 Gene

genes like me logo Genes that share paralogs with KLK11: view

Variants for KLK11 Gene

Sequence variations from dbSNP and Humsavar for KLK11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10413969 -- 51,021,802(+) tgtta(C/T)tgcac downstream-variant-500B, upstream-variant-2KB
rs1048328 -- 51,024,108(-) CCTCA(C/T)GCTGT intron-variant, reference, missense
rs1048344 -- 51,022,447(-) CCTCT(A/G)CGAAC utr-variant-3-prime
rs111481992 -- 51,022,015(+) AAATA(C/G)AAAAA downstream-variant-500B, upstream-variant-2KB
rs111482840 -- 51,023,958(+) GTGAA(C/T)CGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK11 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for KLK11 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK11 Gene

Disorders for KLK11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLK11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fusariosis
  • fusarium infection
- elite association - COSMIC cancer census association via MalaCards
Search KLK11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK11

Genetic Association Database (GAD)
KLK11
Human Genome Epidemiology (HuGE) Navigator
KLK11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK11
genes like me logo Genes that share disorders with KLK11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK11 Gene

Publications for KLK11 Gene

  1. Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. (PMID: 10662548) Yousef G.M. … Diamandis E.P. (Genomics 2000) 2 3 4 22 64
  2. Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. (PMID: 16911518) Mitsui S. … Yamaguchi N. (FEBS J. 2006) 3 4 22 64
  3. Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate. (PMID: 12539228) Nakamura T. … Yamaguchi N. (Prostate 2003) 3 4 22 64
  4. Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. (PMID: 12845660) BorgoA+o C.A. … Katsaros D. (Int. J. Cancer 2003) 3 22 46 64
  5. A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. (PMID: 10872828) Mitsui S. … Yamaguchi N. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64

Products for KLK11 Gene

Sources for KLK11 Gene

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