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KLK11 Gene

protein-coding   GIFtS: 58
GCID: GC19M051525

Kallikrein-Related Peptidase 11

(Previous name: kallikrein 11)
(Previous symbol: PRSS20)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 111 2     hippostasin2
PRSS201 2 3 5     kallikrein-112
TLSP2 3 5     EC 3.4.21.-3
Kallikrein 111 2     Hippostasin3
Serine Protease 202 3     EC 3.4.218
Trypsin-Like Protease2 3     EC 3.4.21.48
hK112 3     

External Ids:    HGNC: 63591   Entrez Gene: 110122   Ensembl: ENSG000001677577   OMIM: 6044345   UniProtKB: Q9UBX73   

Export aliases for KLK11 gene to outside databases

Previous GC identifers: GC19M052155 GC19M051886 GC19M056201 GC19M056217 GC19M047858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK11 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are
differentially expressed.(provided by RefSeq, Nov 2009)

GeneCards Summary for KLK11 Gene:
KLK11 (kallikrein-related peptidase 11) is a protein-coding gene. Diseases associated with KLK11 include scimitar syndrome, and proliferative vitreoretinopathy. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: KLK11_HUMAN, Q9UBX7
Function: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a
kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides
after arginine but not lysine residues

Gene Wiki entry for KLK11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK11 gene promoter:
         ER-alpha   ZID   NF-E2   NF-E2 p45   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLK11 promoter sequence
   Search Chromatin IP Primers for KLK11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051525:  view genomic region     (about GC identifiers)

Start:
51,525,472 bp from pter      End:
51,531,295 bp from pter
Size:
5,824 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLK11_HUMAN, Q9UBX7 (See protein sequence)
Recommended Name: Kallikrein-11 precursor  
Size: 282 amino acids; 31059 Da
Secondary accessions: O75837 Q0WXX5 Q8IXD7 Q9NS65
Alternative splicing: 4 isoforms:  Q9UBX7-2   Q9UBX7-1   Q9UBX7-3   Q9UBX7-4   (Localized in the prostate secretory epithelium)

Explore the universe of human proteins at neXtProt for KLK11: NX_Q9UBX7

Explore proteomics data for KLK11 at MOPED

Post-translational modifications: 

  • About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be
    effected by plasminogen1
  • Glycosylation2 at Asn99, Asn165, Asn181, Asn210
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KLK11 (Q9UBX7) (see all 7)
     GDSGGPL  CLISGWG  PGVYTKV  EGGKDSC 


    See KLK11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129504.1  NP_001161077.1  NP_006844.1  NP_659196.1  

    ENSEMBL proteins: 
     ENSP00000471636   ENSP00000324269   ENSP00000473047   ENSP00000470113   ENSP00000413958  
     ENSP00000324414   ENSP00000375680   ENSP00000470574   ENSP00000470783  

    KLK11 Human Recombinant Protein Products:

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    KLK11 Antibody Products:

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    KLK11 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9UBX7

    ProtoNet protein and cluster: Q9UBX7

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK11_HUMAN, Q9UBX7
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK11_HUMAN, Q9UBX7
    Function: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a
    kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides
    after arginine but not lysine residues

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS9765601
         
    KLK11 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Klk11 (no phenotypes)

    KLK11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Klk11tm1Lex for KLK11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLK11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK11

    miRNA
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    miRTarBase miRNAs that target KLK11:
    hsa-mir-335-5p (MIRT017931)

    Block miRNA regulation of human, mouse, rat KLK11 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLK11
    SwitchGear 3'UTR luciferase reporter plasmidKLK11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLK11

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): KLK11 (NM_001136032)
    Sino Biological Human cDNA Clone for KLK11
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK11

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    Browse ESI BIO Cell Lines and PureStem Progenitors for KLK11 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK11_HUMAN, Q9UBX7: Isoform 1: Secreted
    KLK11_HUMAN, Q9UBX7: Isoform 2: Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    plasma membrane2
    cytosol1
    lysosome1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005794Golgi apparatus IEA--

    KLK11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK11 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK11
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK11
    Interactions:

        Search GeneGlobe Interaction Network for KLK11

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    KLK11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK11

    Selected Novoseek inferred chemical compound relationships for KLK11 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 86 205 11341363 (4), 15781388 (3), 16982065 (3), 10662548 (3) (see all 99)
    babim 76.7 1 8437115 (1)
    tlck 76.6 10 15507121 (1), 16768813 (1), 9204960 (1), 9532790 (1) (see all 8)
    leupeptin 74.2 4 14500256 (1), 9204960 (1), 18445191 (1), 9301143 (1)
    benzamidine 73.9 1 16768813 (1)
    chymostatin 68.4 1 9301143 (1)
    tpck 63.6 1 15507121 (1)
    n-tosyl-l-phenylalanine chloromethyl ketone 61.5 1 15507121 (1)
    aprotinin 54.9 2 14500256 (1), 10777616 (1)
    amidines 52.2 1 10715155 (1)



    KLK11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLK11 gene (4 alternative transcripts): 
    NM_001136032.2  NM_001167605.1  NM_006853.2  NM_144947.1  

    Unigene Cluster for KLK11:

    Kallikrein-related peptidase 11
    Hs.57771  [show with all ESTs]
    Unigene Representative Sequence: AK308207
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600362 ENST00000319720(uc002pvf.1) ENST00000594768 ENST00000593681
    ENST00000453757(uc002pvc.4 uc010eom.3) ENST00000319756(uc002pvd.1 uc002pve.1)
    ENST00000391804(uc002pvb.2) ENST00000594827 ENST00000598799 ENST00000594458
    ENST00000601671

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLK11 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLK11
    SwitchGear 3'UTR luciferase reporter plasmidKLK11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLK11
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): KLK11 (NM_001136032)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK11
    Primer
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    OriGene qPCR primer pairs and template standards for KLK11
    OriGene qSTAR qPCR primer pairs in human, mouse for KLK11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLK11
      QuantiTect SYBR Green Assays in human, mouse, rat KLK11
      QuantiFast Probe-based Assays in human, mouse, rat KLK11

    Additional mRNA sequence: 

    AB012917.1 AB013730.1 AB041036.1 AB078780.1 AB259014.1 AB261897.1 AK308207.1 AY359014.1 
    BC015551.2 BC022068.1 

    7 DOTS entries:

    DT.100752394  DT.312084  DT.121428403  DT.95209682  DT.100752393  DT.97835843  DT.121428407 

    Selected AceView cDNA sequences (see all 66):

    BG697071 AY359014 AA477282 BM837078 BC015551 AB012917 NM_006853 AB041036 
    BM982377 AA402028 AW969530 BU684799 NM_144947 CA437458 AB013730 AA435952 
    BU676834 AW166796 BC022068 CD107547 BG747134 BM559782 AI183346 BF222155 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLK11 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c
    SP1:        -     -     -     -                 -                                                         
    SP2:              -     -     -                 -                                                         
    SP3:                          -                 -                                                         
    SP4:                                            -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for KLK11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGTGCCA
    KLK11 Expression
    About this image

    KLK11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57771

    UniProtKB/Swiss-Prot: KLK11_HUMAN, Q9UBX7
    Tissue specificity: Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform
    2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at
    protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLK11 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk111 , 5 kallikrein related-peptidase 111, 5 82.97(n)1
    78.62(a)1
      7 (28.26 cM)5
    565381  NM_001177373.11  NP_001170844.11 
     437746175 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    46(a)
    1 → many
    GL343276.1(1578128-1583778)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004851891 trypsin-like 55.01(n)
    50.67(a)
      100485189  XM_002941019.2  XP_002941065.1 


    ENSEMBL Gene Tree for KLK11 (if available)
    TreeFam Gene Tree for KLK11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK11 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK72  KLK142  KLK92  
    KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK11 using alignment to 5 protein entries:     KLK11_HUMAN (see all proteins) (see all similar genes):
    KLK8    KLK9    KLK5    KLK13    KLK15    KLK6
    KLK14    KLK4    PRSS45    F2    KLK2    KLK1
    PRSS1    KLK12    KLK7    PRSS3    KLK3    APS

    KLK11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KLK11
    PGOHUM00000262495


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK11 (see all 226)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165388081,2
    F--51525500(+) TTTAGC/AAAATA 4 -- ut311Minor allele frequency- A:0.01WA 118
    rs1927758811,2
    --51525548(+) TGGGGC/TTGGGG 4 -- ut310--------
    rs1491692611,2
    C--51525660(+) ATTAAG/TTGACA 4 -- ut310--------
    rs10483441,2
    C,F,O,A,H--51525703(-) CCTCTA/GCGAAC 4 -- ut31 ese325Minor allele frequency- G:0.34MN EA NA NS WA CSA 2746
    rs1844377331,2
    --51525740(+) AGAGTA/GAACAG 4 -- ut310--------
    rs2022134611,2
    --51525755(+) CAAACA/GCCAAG 4 -- ut310--------
    rs781018381,2
    C,F--51525798(+) GGTCCA/CGTCTA 4 -- ut311Minor allele frequency- C:0.03WA 118
    rs1462443521,2
    C,F--51525816(+) TTCATC/TGTCTC 8 T syn12Minor allele frequency- T:0.00NA EU 5875
    rs1128652361,2
    C,F--51525888(+) CACGGA/GTCCTG 8 D syn12Minor allele frequency- G:0.00CSA NA 4554
    rs2014492611,2
    --51525940(+) GAGGGC/TCCCCG 8 D G mis10--------

    HapMap Linkage Disequilibrium report for KLK11 (51525472 - 51531295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KLK11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912291CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK11
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604434    OMIM disorders: --

    Selected diseases for KLK11 (see all 26):    
    About MalaCards
    scimitar syndrome    proliferative vitreoretinopathy    retinal detachment    periodontal disease
    duchenne muscular dystrophy    influenza    periodontitis    malignant mesothelioma
    psoriasis    gingivitis    prostate cancer    muscular dystrophy
    alzheimer's disease    prostatitis    osteoarthritis    asthma
    laryngitis    dementia    retinitis    parkinson's disease


    KLK11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for KLK11 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    airways disease 35.3 4 11326745 (1), 14500256 (1), 9565616 (1), 16336275 (1)
    prostate cancer 26.9 20 11550212 (4), 15893744 (3), 19242826 (2), 16800741 (2) (see all 9)
    periodontal diseases 21.6 1 7553388 (1)
    metastasis 1.28 5 11311057 (1), 16420035 (1), 11745444 (1), 15358180 (1) (see all 5)
    cancer 1.14 10 17487371 (2), 15781388 (1), 19242826 (1), 12736044 (1) (see all 7)
    carcinoma squamous cell 0 1 15558215 (1)
    virus infection 0 1 16325937 (1)
    asthma 0 2 11325588 (1), 11341363 (1)
    inflammation 0 2 1338289 (1), 9568894 (1)
    breast cancer 0 6 17487371 (2), 10373425 (1)

    Genetic Association Database (GAD): KLK11
    Human Genome Epidemiology (HuGE) Navigator: KLK11 (1 document)

    Export disorders for KLK11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK11 gene, integrated from 10 sources (see all 240):
    (articles sorted by number of sources associating them with KLK11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. (PubMed id 10662548)1, 2, 3, 9 Yousef G.M.... Diamandis E.P. (Genomics 2000)
    2. cDNA cloning and expression of a novel serine protease, TLSP. (PubMed id 9765601)1, 2, 3 Yoshida S.... Shiosaka S. (Biochim. Biophys. Acta 1998)
    3. A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. (PubMed id 10872828)1, 2, 9 Mitsui S.... Yamaguchi N. (Biochem. Biophys. Res. Commun. 2000)
    4. Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate. (PubMed id 12539228)1, 2, 9 Nakamura T.... Yamaguchi N. (Prostate 2003)
    5. Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. (PubMed id 16911518)1, 2, 9 Mitsui S.... Yamaguchi N. (FEBS J. 2006)
    6. Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. (PubMed id 12845660)1, 4, 9 BorgoA+o C.A....Katsaros D. (Int. J. Cancer 2003)
    7. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    8. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (Biol. Chem. 2006)
    9. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (Biol. Chem. 2006)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11012 HGNC: 6359 AceView: KLK11 Ensembl:ENSG00000167757 euGenes: HUgn11012
    ECgene: KLK11 H-InvDB: KLK11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLK11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLK11 gene:
    Search GeneIP for patents involving KLK11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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