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Aliases for KLK10 Gene

Aliases for KLK10 Gene

  • Kallikrein-Related Peptidase 10 2 3
  • Normal Epithelial Cell-Specific 1 3 4
  • Protease Serine-Like 1 3 4
  • PRSSL1 3 4
  • NES1 3 4
  • Breast Normal Epithelial Cell Associated Serine Protease 3
  • Kallikrein 10 Protein 12 3
  • Kallikrein 10 Protein 13 3
  • Protease, Serine-Like, 1 3
  • Kallikrein 10 Protein 1 3
  • Kallikrein 10 Protein 2 3
  • Kallikrein 10 Protein 3 3
  • Kallikrein 10 Protein 4 3
  • Kallikrein 10 Protein 5 3
  • Kallikrein 10 Protein 7 3
  • Kallikrein 10 Protein 8 3
  • Kallikrein 10 Protein 9 3
  • Kallikrein 10 2
  • EC 3.4.21.74 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for KLK10 Gene

Previous HGNC Symbols for KLK10 Gene

  • PRSSL1

Previous GeneCards Identifiers for KLK10 Gene

  • GC19M052148
  • GC19M051877
  • GC19M056193
  • GC19M056209
  • GC19M051516
  • GC19M047848

Summaries for KLK10 Gene

Entrez Gene Summary for KLK10 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK10 Gene

KLK10 (Kallikrein-Related Peptidase 10) is a Protein Coding gene. Diseases associated with KLK10 include ovarian cancer and prostate cancer. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK10 Gene

  • Has a tumor-suppressor role for NES1 in breast and prostate cancer

Gene Wiki entry for KLK10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK10 Gene

Genomics for KLK10 Gene

Regulatory Elements for KLK10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLK10 Gene

Chromosome:
19
Start:
51,012,739 bp from pter
End:
51,020,175 bp from pter
Size:
7,437 bases
Orientation:
Minus strand

Genomic View for KLK10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK10 Gene

Proteins for KLK10 Gene

  • Protein details for KLK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43240-KLK10_HUMAN
    Recommended name:
    Kallikrein-10
    Protein Accession:
    O43240
    Secondary Accessions:
    • A6NC12
    • Q53YL3
    • Q99920
    • Q9GZW9

    Protein attributes for KLK10 Gene

    Size:
    276 amino acids
    Molecular mass:
    30170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLK10 Gene

Proteomics data for KLK10 Gene at MOPED

Selected DME Specific Peptides for KLK10 Gene

Post-translational modifications for KLK10 Gene

  • Glycosylation at Asn 39
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK10 Gene

Antibody Products

  • R&D Systems Antibodies for KLK10 (Kallikrein 10)

Domains & Families for KLK10 Gene

Gene Families for KLK10 Gene

Suggested Antigen Peptide Sequences for KLK10 Gene

Graphical View of Domain Structure for InterPro Entry

O43240

UniProtKB/Swiss-Prot:

KLK10_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK10: view

Function for KLK10 Gene

Molecular function for KLK10 Gene

UniProtKB/Swiss-Prot Function:
Has a tumor-suppressor role for NES1 in breast and prostate cancer

Enzyme Numbers (IUBMB) for KLK10 Gene

Gene Ontology (GO) - Molecular Function for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 8764136
genes like me logo Genes that share ontologies with KLK10: view

Phenotypes for KLK10 Gene

GenomeRNAi human phenotypes for KLK10:
genes like me logo Genes that share phenotypes with KLK10: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK10

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for KLK10 Gene

Localization for KLK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK10 Gene COMPARTMENTS Subcellular localization image for KLK10 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK10: view

Pathways & Interactions for KLK10 Gene

genes like me logo Genes that share pathways with KLK10: view

Pathways by source for KLK10 Gene

Interacting Proteins for KLK10 Gene

Selected Interacting proteins: O43240-KLK10_HUMAN for KLK10 Gene via MINT I2D

Symbol External ID(s) Details
LRIF1
RIF1

Gene Ontology (GO) - Biological Process for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with KLK10: view

No data available for SIGNOR curated interactions for KLK10 Gene

Drugs & Compounds for KLK10 Gene

(9) Drugs for KLK10 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mifepristone Approved, Investigational Pharma Antagonist Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 132
Dihydrotestosterone Experimental, Illicit Pharma Agonist 13
estrogen Pharma 0
Norgestrel Pharma 27
Progestins Pharma 408

(1) Additional Compounds for KLK10 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Steroid
genes like me logo Genes that share compounds with KLK10: view

Transcripts for KLK10 Gene

Unigene Clusters for KLK10 Gene

Kallikrein-related peptidase 10:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3:

Relevant External Links for KLK10 Gene

GeneLoc Exon Structure for
KLK10
ECgene alternative splicing isoforms for
KLK10

Expression for KLK10 Gene

mRNA expression in normal human tissues for KLK10 Gene

mRNA differential expression in normal tissues according to GTEx for KLK10 Gene

This gene is overexpressed in Esophagus - Mucosa (x23.1), Vagina (x6.8), Cervix - Ectocervix (x6.5), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for KLK10 Gene

This gene is overexpressed in Cervix (48.1), Saliva (8.2), and Hair follicle (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK10 Gene



SOURCE GeneReport for Unigene cluster for KLK10 Gene Hs.275464

mRNA Expression by UniProt/SwissProt for KLK10 Gene

O43240-KLK10_HUMAN
Tissue specificity: Expressed in breast, ovary and prostate
genes like me logo Genes that share expression patterns with KLK10: view

Protein tissue co-expression partners for KLK10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KLK10 Gene

Orthologs for KLK10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK10 35
  • 82.49 (n)
  • 82.25 (a)
KLK10 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK10 35
  • 86.71 (n)
  • 85.14 (a)
KLK10 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk10 35
  • 76.89 (n)
  • 68.98 (a)
Klk10 16
Klk10 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLK10 35
  • 98.79 (n)
  • 98.19 (a)
KLK10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klk10 35
  • 75.6 (n)
  • 69.57 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia KLK10 36
  • 48 (a)
OneToOne
Species with no ortholog for KLK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK10 Gene

ENSEMBL:
Gene Tree for KLK10 (if available)
TreeFam:
Gene Tree for KLK10 (if available)

Paralogs for KLK10 Gene

genes like me logo Genes that share paralogs with KLK10: view

Variants for KLK10 Gene

Sequence variations from dbSNP and Humsavar for KLK10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1698 -- 51,014,337(+) ATCAC(A/C)ATGAA utr-variant-3-prime
rs9524 -- 51,014,475(-) CTCCC(A/C/G/T)GCTGT utr-variant-3-prime
rs10426 -- 51,014,542(-) GGAAG(C/T)CGGTC utr-variant-3-prime
rs1061368 -- 51,016,090(-) CGGAC(C/G)ACTCG reference, synonymous-codon
rs1140280 -- 51,016,129(-) GATGA(C/T)CACCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KLK10 Gene

Variant ID Type Subtype PubMed ID
nsv912291 CNV Loss 21882294
esv2677627 CNV Deletion 23128226

Variation tolerance for KLK10 Gene

Residual Variation Intolerance Score: 56.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK10 Gene

HapMap Linkage Disequilibrium report
KLK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK10 Gene

Disorders for KLK10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLK10 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • tumor of the ovary
prostate cancer
  • prostate cancer, hereditary, 5
breast cancer
  • breast cancer, invasive ductal
- elite association
Search KLK10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK10

Genetic Association Database (GAD)
KLK10
Human Genome Epidemiology (HuGE) Navigator
KLK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK10
genes like me logo Genes that share disorders with KLK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK10 Gene

Publications for KLK10 Gene

  1. The new human kallikrein gene family: implications in carcinogenesis. (PMID: 10675891) Diamandis E.P. … Obiezu C.V. (Trends Endocrinol. Metab. 2000) 2 23 67
  2. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. (PMID: 8764136) Liu X.-L. … Band V. (Cancer Res. 1996) 2 23 67
  3. Analysis of chemotherapy response programs in ovarian cancers by the next-generation sequencing technologies. (PMID: 20181382) Cheng L. … Lin B. (Gynecol. Oncol. 2010) 23 67
  4. Three dysregulated miRNAs control kallikrein 10 expression and cell proliferation in ovarian cancer. (PMID: 20354523) White N.M. … Yousef G.M. (Br. J. Cancer 2010) 23 67
  5. Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer. (PMID: 20360129) Planque C. … Courty Y. (Clin. Chem. 2010) 23 67

Products for KLK10 Gene

Sources for KLK10 Gene

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