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KLK10 Gene

protein-coding   GIFtS: 62
GCID: GC19M051516

Kallikrein-Related Peptidase 10

(Previous name: kallikrein 10)
(Previous symbol: PRSSL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kallikrein-Related Peptidase 101 2     Kallikrein 10 Protein 32
PRSSL11 2 3 5     Kallikrein 10 Protein 42
NES12 3 5     Kallikrein 10 Protein 72
Normal Epithelial Cell-Specific 12 3     Kallikrein 10 Protein 82
Protease Serine-Like 12 3     Kallikrein 10 Protein 92
Kallikrein 101     kallikrein-102
Breast Normal Epithelial Cell Associated Serine Protease2     Protease, Serine-Like, 12
Kallikrein 10 Protein 12     EC 3.4.21.-3
Kallikrein 10 Protein 122     EC 3.4.218
Kallikrein 10 Protein 22     EC 3.4.21.748

External Ids:    HGNC: 63581   Entrez Gene: 56552   Ensembl: ENSG000001294517   OMIM: 6026735   UniProtKB: O432403   

Export aliases for KLK10 gene to outside databases

Previous GC identifers: GC19M052148 GC19M051877 GC19M056193 GC19M056209 GC19M047848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLK10 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate
cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
(provided by RefSeq, Jul 2008)

GeneCards Summary for KLK10 Gene:
KLK10 (kallikrein-related peptidase 10) is a protein-coding gene. Diseases associated with KLK10 include lung squamous cell carcinoma, and ductal carcinoma in situ. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is ENSG00000269741.

UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240
Function: Has a tumor-suppressor role for NES1 in breast and prostate cancer

Gene Wiki entry for KLK10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLK10 gene promoter:
         ER-alpha   ZID   NF-E2 p45   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK10 promoter sequence
   Search Chromatin IP Primers for KLK10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13

KLK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK10 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051516:  view genomic region     (about GC identifiers)

Start:
51,515,995 bp from pter      End:
51,523,431 bp from pter
Size:
7,437 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240 (See protein sequence)
Recommended Name: Kallikrein-10 precursor  
Size: 276 amino acids; 30170 Da
Developmental stage: Down-regulated during breast cancer progression
Secondary accessions: A6NC12 Q53YL3 Q99920 Q9GZW9

Explore the universe of human proteins at neXtProt for KLK10: NX_O43240

Explore proteomics data for KLK10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn39
  • 4 DME Specific Peptides for KLK10 (O43240)
     QGILSWG  VLTAAHC  SGGPLVC  WVLTAAH 


    See KLK10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070968.1  NP_002767.2  NP_665895.1  

    ENSEMBL proteins: 
     ENSP00000311746   ENSP00000351640   ENSP00000472773   ENSP00000471610   ENSP00000375681  

    KLK10 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for KLK10
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    Novus Biologicals KLK10 Proteins
    Novus Biologicals KLK10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLK10

    KLK10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KLK10 (Kallikrein 10)
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    KLK10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for KLK10
    Cloud-Clone Corp. CLIAs for KLK10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry O43240

    ProtoNet protein and cluster: O43240

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK10_HUMAN, O43240
    Function: Has a tumor-suppressor role for NES1 in breast and prostate cancer

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.742 EC 3.4.21.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS8764136
         
    KLK10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLK10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK10

    miRNA
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    miRTarBase miRNAs that target KLK10:
    hsa-mir-224-5p (MIRT000454), hsa-mir-375 (MIRT019672), hsa-let-7f-5p (MIRT000455)

    Block miRNA regulation of human, mouse, rat KLK10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLK10 (see all 15):
    hsa-miR-194* hsa-miR-4265 hsa-miR-582-3p hsa-miR-140-5p hsa-miR-516b* hsa-miR-646 hsa-miR-1262 hsa-miR-214
    SwitchGear 3'UTR luciferase reporter plasmidKLK10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLK10
    Predesigned siRNA for gene silencing in human, mouse, rat KLK10

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for KLK10

    Clone
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    OriGene clones in human, mouse for KLK10 (see all 14)
    OriGene ORF clones in mouse, rat for KLK10
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    GenScript: all cDNA clones in your preferred vector (see all 3): KLK10 (NM_002776)
    Sino Biological Human cDNA Clone for KLK10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK10

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for KLK10
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLK10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLK10_HUMAN, O43240: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus2
    cytoskeleton1
    cytosol1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    KLK10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLK10 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLK10
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLK10
    Interactions:

        Search GeneGlobe Interaction Network for KLK10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for KLK10 (O432402, 3 ENSP000003117464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRIF1Q5T3J32, 3MINT-63110 I2D: score=4 
    RIF1Q5UIP03I2D: score=1 
    BCAP31ENSP000003923304STRING: ENSP00000392330
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007049cell cycle IEA--

    KLK10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLK10

    10 Novoseek inferred chemical compound relationships for KLK10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    norgestrel 70 3 10810385 (2), 14568187 (1)
    serine 64.6 16 8372098 (1), 9647736 (1), 10775039 (1), 9809976 (1) (see all 13)
    progestins 50.6 5 14568187 (3), 10810385 (1)
    dihydrotestosterone 41.2 3 17937626 (1), 10810385 (1), 14568187 (1)
    steroid 34.1 12 14568187 (5), 10810385 (2), 10675891 (1), 17937626 (1)
    mifepristone 33.5 2 10810385 (1), 14568187 (1)
    leucine 22.6 1 18059333 (1)
    threonine 21.5 1 12438709 (1)
    estrogen 12 4 10810385 (2), 19383315 (1), 14568187 (1)
    alanine 10.6 1 18059333 (1)



    KLK10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLK10 gene (3 alternative transcripts): 
    NM_001077500.1  NM_002776.4  NM_145888.2  

    Unigene Cluster for KLK10:

    Kallikrein-related peptidase 10
    Hs.275464  [show with all ESTs]
    Unigene Representative Sequence: NM_002776
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309958(uc002puz.3) ENST00000358789(uc002puy.3) ENST00000601467
    ENST00000599987 ENST00000599077 ENST00000391805(uc002pva.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLK10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLK10 (see all 15):
    hsa-miR-194* hsa-miR-4265 hsa-miR-582-3p hsa-miR-140-5p hsa-miR-516b* hsa-miR-646 hsa-miR-1262 hsa-miR-214
    SwitchGear 3'UTR luciferase reporter plasmidKLK10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLK10
    Predesigned siRNA for gene silencing in human, mouse, rat KLK10
    Clone
    Products:
         
    OriGene clones in human, mouse for KLK10 (see all 14)
    OriGene ORF clones in mouse, rat for KLK10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KLK10 (NM_002776)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLK10
    OriGene qSTAR qPCR primer pairs in human, mouse for KLK10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLK10
      QuantiTect SYBR Green Assays in human, mouse, rat KLK10
      QuantiFast Probe-based Assays in human, mouse, rat KLK10

    Additional mRNA sequence: 

    AF024605.1 AK026045.1 AK292365.1 AK309456.1 AY561635.1 BC002710.2 CR450327.1 

    6 DOTS entries:

    DT.447393  DT.100751370  DT.86853019  DT.40270513  DT.75127791  DT.95233857 

    Selected AceView cDNA sequences (see all 114):

    AA477256 AY561635 NM_145888 AI961896 NM_002776 AI677641 H25116 BM783960 
    BF515111 CB216785 AI801349 AA582886 CA312154 AA293304 BG678912 CB050946 
    BM726274 AW848957 AF024605 BX283724 BM830577 AA459626 BM717931 BE395736 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLK10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:        -                                             
    SP2:                                                      
    SP3:                                                      


    ECgene alternative splicing isoforms for KLK10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGCTTAA
    KLK10 Expression
    About this image


    KLK10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Osteochondro Mesenchymal Cells Vertebrae
             Bone Marrow
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Osteochondro Mesenchymal Cells Vertebrae
             Intervertebral Disc
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal epithelial stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Somite (Muscoskeletal System)
             Sacral Mesenchymal Sclerotome
    KLK10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLK10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.275464

    UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240
    Tissue specificity: Expressed in breast, ovary and prostate

        Custom PCR Arrays for KLK10
    Primer
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    OriGene qPCR primer pairs and template standards for KLK10
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLK10
    QuantiTect SYBR Green Assays in human, mouse, rat KLK10
    QuantiFast Probe-based Assays in human, mouse, rat KLK10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK10 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk101 , 5 kallikrein related-peptidase 101, 5 76.89(n)1
    68.98(a)1
      7 (28.26 cM)5
    695401  NM_133712.21  NP_598473.11 
     437810545 


    ENSEMBL Gene Tree for KLK10 (if available)
    TreeFam Gene Tree for KLK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLK10 gene
    ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  KLK92  
    KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for KLK10 using alignment to 4 protein entries:     KLK10_HUMAN (see all proteins) (see all similar genes):
    KLK9    KLK7    KLK5    KLK12    KLK13    PRSS1
    KLK11    TRY8    KLK14    PRSS3    KLK1    KLK8
    PRSS2    KLK15    KLK4    CFD    DF    GZMK

    KLK10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLK10 (see all 286)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27394281,2
    C,F,H--51515545(+) ataggT/Agtgag 3 -- int113Minor allele frequency- A:0.28NA WA CSA EA 375
    rs72483421,2
    C,F,A,H--51515549(+) gagtgA/Ggccac 3 -- int15Minor allele frequency- G:0.16NA WA 244
    rs602504081,2
    C--51515558(+) ACTGCG/ACCCAG 3 -- int12Minor allele frequency- A:0.08WA 120
    rs65095101,2
    C,F,A,H--51515668(+) agtcaT/Cacagc 3 -- int122Minor allele frequency- C:0.22NS EA NA WA 2762
    rs569493521,2
    C,F--51515817(+) ATACCC/TCCTTC 3 -- int13Minor allele frequency- T:0.08WA CSA 122
    rs25694431,2
    C,F,A,H--51515833(+) CAGCAC/GTGATC 3 -- int114Minor allele frequency- G:0.35NS EA WA NA CSA 792
    rs1479179551,2
    --51515849(+) GTGTTA/GTGTGT 3 -- int10--------
    rs1420760211,2
    --51515890(+) CCGGGC/TACAAT 3 -- int10--------
    rs1854929651,2
    --51515964(+) GAAGGA/GTGACA 3 -- int10--------
    rs27394291,2
    C,F,A,H--51516015(+) tataaT/Caggtg 3 -- ut3122Minor allele frequency- C:0.38NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for KLK10 (51515995 - 51523431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLK10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677627CNV Deletion23128226
    nsv912291CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602673    OMIM disorders: --

    Selected diseases for KLK10 (see all 27):    
    About MalaCards
    lung squamous cell carcinoma    ductal carcinoma in situ    peutz-jeghers syndrome    pancreatic ductal adenocarcinoma
    frontotemporal dementia    prostate cancer    testicular cancer    ovarian cancer
    tongue cancer    papillary carcinoma    lymphoblastic leukemia    prostatitis
    dementia    squamous cell carcinoma    gingivitis    breast cancer
    colorectal cancer    pancreatitis    alzheimer's disease    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for KLK10:
    Ovarian cancer

    KLK10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for KLK10 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 54.9 9 16557045 (3), 11920956 (2), 12727843 (2)
    breast cancer 49.6 19 9809976 (3), 10810385 (3), 11691827 (2), 11705853 (2) (see all 12)
    cancer 41.1 15 11920956 (3), 9809976 (2), 14568187 (2), 10675891 (1) (see all 8)
    carcinoma ductal 36.1 8 11705853 (3), 12788170 (2)
    prostate cancer 34.6 6 9809976 (2), 16103744 (1), 11705853 (1), 16254462 (1)
    ovarian carcinoma 33.1 4 12821340 (4)
    breast carcinoma 30.9 1 10810385 (1)
    tumors 26.8 25 12821340 (3), 16928223 (3), 11920956 (2), 12788170 (2) (see all 15)
    primary tumor 17.6 2 18485221 (1), 11691827 (1)
    gastric cancer 16.8 8 17182177 (3), 16928223 (2), 16103744 (1)

    Genetic Association Database (GAD): KLK10
    Human Genome Epidemiology (HuGE) Navigator: KLK10 (4 documents)

    Export disorders for KLK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLK10 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with KLK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. (PubMed id 8764136)1, 2, 3, 9 Liu X.-L.... Band V. (Cancer Res. 1996)
    2. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. (PubMed id 16103744)1, 2, 9 Yousef G.M.... Diamandis E.P. (Tumor Biol. 2005)
    3. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. (PubMed id 11920956)1, 4, 9 Bharaj B.B....Diamandis E.P. (Prostate 2002)
    4. The role for NES1 serine protease as a novel tumor suppressor. (PubMed id 9809976)1, 2, 9 Goyal J.... Band V. (Cancer Res. 1998)
    5. Structural characterization and mapping of the normal epithelial cell-specific 1 gene. (PubMed id 9647736)1, 2, 9 Luo L.-Y....Diamandis E.P. (Biochem. Biophys. Res. Commun. 1998)
    6. The new human kallikrein gene family: implications in carcinogenesis. (PubMed id 10675891)1, 3, 9 Diamandis E.P.... Obiezu C.V. (Trends Endocrinol. Metab. 2000)
    7. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (Cancer Prev Res (Phila) 2010)
    8. Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival. (PubMed id 20686372)1, 4 Batra J....Spurdle A.B. (Int. J. Gynecol. Cancer 2010)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    10. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5655 HGNC: 6358 AceView: KLK10 Ensembl:ENSG00000129451 euGenes: HUgn5655
    ECgene: KLK10 H-InvDB: KLK10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLK10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLK10 gene:
    Search GeneIP for patents involving KLK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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