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Aliases for KLK10 Gene

Aliases for KLK10 Gene

  • Kallikrein Related Peptidase 10 2 3 5
  • Normal Epithelial Cell-Specific 1 3 4
  • Protease Serine-Like 1 3 4
  • PRSSL1 3 4
  • NES1 3 4
  • Breast Normal Epithelial Cell Associated Serine Protease 3
  • Kallikrein 10 Protein 12 3
  • Kallikrein 10 Protein 13 3
  • Kallikrein 10 Protein 1 3
  • Kallikrein 10 Protein 2 3
  • Kallikrein 10 Protein 3 3
  • Kallikrein 10 Protein 4 3
  • Kallikrein 10 Protein 5 3
  • Kallikrein 10 Protein 7 3
  • Kallikrein 10 Protein 8 3
  • Kallikrein 10 Protein 9 3
  • Kallikrein 10 2
  • Kallikrein-10 3
  • EC 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for KLK10 Gene

Previous HGNC Symbols for KLK10 Gene

  • PRSSL1

Previous GeneCards Identifiers for KLK10 Gene

  • GC19M052148
  • GC19M051877
  • GC19M056193
  • GC19M056209
  • GC19M051516
  • GC19M047848

Summaries for KLK10 Gene

Entrez Gene Summary for KLK10 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK10 Gene

KLK10 (Kallikrein Related Peptidase 10) is a Protein Coding gene. Diseases associated with KLK10 include Ovarian Cancer and Breast Cancer. Among its related pathways are Collagen biosynthesis and modifying enzymes and MSP-RON Signaling. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK10 Gene

  • Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Gene Wiki entry for KLK10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK10 Gene

Genomics for KLK10 Gene

Regulatory Elements for KLK10 Gene

Enhancers for KLK10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051018 0.5 ENCODE 24.4 +0.7 743 2.4 GLIS2 ZNF302 ZNF366 ZNF416 ETV6 EGR2 SMARCA5 ZNF362 SP3 CEBPB KLK10 ZNF649 ZNF577 KLK13 KLK6 KLK14 SNORD88C C19orf48 LINC01869 ENSG00000267879
GH19F051016 0.7 ENCODE 23.6 +2.8 2790 1.5 PKNOX1 GLI4 ZNF121 GLIS2 ZNF143 KLF7 SP3 REST GLIS1 SP7 KLK10 ZNF577 ZNF175 KLK13 KLK6 ENSG00000269483 ZNF649 KLK14 ZNF615 LINC01869
GH19F051070 0.2 ENCODE 11.3 -51.0 -50953 1.0 PKNOX1 DPF2 ZNF217 ARID3A CTBP1 JUND GATA3 NCOR1 RCOR1 CUX1 POLD1 CTU1 KLK10 KLK11 KLK2 KLK13 KLK14
GH19F050999 1.1 Ensembl ENCODE 6.7 +18.6 18639 3.6 HDGF HDAC1 PKNOX1 ATF1 CREM KLF13 USF2 SP1 RAD51 ZNF341 KLK8 KLK10 KLK7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KLK10 on UCSC Golden Path with GeneCards custom track

Promoters for KLK10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KLK10 Gene

51,012,739 bp from pter
51,020,175 bp from pter
7,437 bases
Minus strand

Genomic View for KLK10 Gene

Genes around KLK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK10 Gene

Proteins for KLK10 Gene

  • Protein details for KLK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NC12
    • Q53YL3
    • Q99920
    • Q9GZW9

    Protein attributes for KLK10 Gene

    276 amino acids
    Molecular mass:
    30170 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLK10 Gene

neXtProt entry for KLK10 Gene

Selected DME Specific Peptides for KLK10 Gene


Post-translational modifications for KLK10 Gene

  • Glycosylation at Asn 39
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK10 (Kallikrein 10)
  • Cloud-Clone Corp. Antibodies for KLK10

Domains & Families for KLK10 Gene

Gene Families for KLK10 Gene

Suggested Antigen Peptide Sequences for KLK10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK10: view

Function for KLK10 Gene

Molecular function for KLK10 Gene

UniProtKB/Swiss-Prot Function:
Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Enzyme Numbers (IUBMB) for KLK10 Gene

Gene Ontology (GO) - Molecular Function for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,TAS 8764136
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK10: view
genes like me logo Genes that share phenotypes with KLK10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK10 Gene

Localization for KLK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK10 Gene


Subcellular locations from

Jensen Localization Image for KLK10 Gene COMPARTMENTS Subcellular localization image for KLK10 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK10: view

Pathways & Interactions for KLK10 Gene

genes like me logo Genes that share pathways with KLK10: view

Pathways by source for KLK10 Gene

Interacting Proteins for KLK10 Gene

Selected Interacting proteins: O43240-KLK10_HUMAN for KLK10 Gene via IID

Gene Ontology (GO) - Biological Process for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with KLK10: view

No data available for SIGNOR curated interactions for KLK10 Gene

Drugs & Compounds for KLK10 Gene

(9) Drugs for KLK10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK10: view

Transcripts for KLK10 Gene

Unigene Clusters for KLK10 Gene

Kallikrein-related peptidase 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -

Relevant External Links for KLK10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLK10 Gene

mRNA differential expression in normal tissues according to GTEx for KLK10 Gene

This gene is overexpressed in Esophagus - Mucosa (x23.1), Vagina (x6.8), Cervix - Ectocervix (x6.5), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for KLK10 Gene

This gene is overexpressed in Cervix (48.1), Saliva (8.2), and Hair follicle (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK10 Gene

Protein tissue co-expression partners for KLK10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLK10 Gene:


SOURCE GeneReport for Unigene cluster for KLK10 Gene:


mRNA Expression by UniProt/SwissProt for KLK10 Gene:

Tissue specificity: Expressed in breast, ovary and prostate.
genes like me logo Genes that share expression patterns with KLK10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KLK10 Gene

Orthologs for KLK10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLK10 34 35
  • 98.79 (n)
(Canis familiaris)
Mammalia KLK10 34 35
  • 86.71 (n)
(Bos Taurus)
Mammalia KLK10 34 35
  • 82.49 (n)
(Mus musculus)
Mammalia Klk10 34 16 35
  • 76.89 (n)
(Rattus norvegicus)
Mammalia Klk10 34
  • 75.6 (n)
(Ornithorhynchus anatinus)
Mammalia KLK10 35
  • 48 (a)
Species where no ortholog for KLK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK10 Gene

Gene Tree for KLK10 (if available)
Gene Tree for KLK10 (if available)

Paralogs for KLK10 Gene

Variants for KLK10 Gene

Sequence variations from dbSNP and Humsavar for KLK10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10413539 -- 51,021,655(+) ggggc(A/G)acata upstream-variant-2KB
rs10413969 -- 51,021,802(+) tgtta(C/T)tgcac downstream-variant-500B, upstream-variant-2KB
rs10423037 -- 51,017,677(+) TAACA(A/C)AACGG intron-variant
rs10423292 -- 51,017,822(+) CTACA(A/C)AAACA intron-variant
rs10424744 -- 51,017,668(+) GGGTG(G/T)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK10 Gene

Variant ID Type Subtype PubMed ID
esv2677627 CNV deletion 23128226
nsv1140251 OTHER inversion 24896259
nsv579961 CNV loss 21841781

Variation tolerance for KLK10 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK10 Gene

Disorders for KLK10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLK10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
breast cancer
  • breast cancer, invasive ductal
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search KLK10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KLK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK10 Gene

Publications for KLK10 Gene

  1. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. (PMID: 8764136) Liu X.-L. … Band V. (Cancer Res. 1996) 2 3 4 22 64
  2. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. (PMID: 16103744) Yousef G.M. … Diamandis E.P. (Tumor Biol. 2005) 3 4 22 64
  3. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. (PMID: 11920956) Bharaj B.B. … Diamandis E.P. (Prostate 2002) 3 22 46 64
  4. The new human kallikrein gene family: implications in carcinogenesis. (PMID: 10675891) Diamandis E.P. … Obiezu C.V. (Trends Endocrinol. Metab. 2000) 2 3 22 64
  5. Structural characterization and mapping of the normal epithelial cell-specific 1 gene. (PMID: 9647736) Luo L.-Y. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 1998) 3 4 22 64

Products for KLK10 Gene

Sources for KLK10 Gene

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