Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLK10 Gene

protein-coding   GIFtS: 63
GCID: GC19M051516

Kallikrein-Related Peptidase 10

(Previous name: kallikrein 10)
(Previous symbol: PRSSL1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kallikrein-Related Peptidase 101 2     Breast Normal Epithelial Cell Associated Serine Protease2
PRSSL11 2 3 5     kallikrein-102
NES12 3 5     Protease, Serine-Like, 12
Kallikrein 101 2     EC 3.4.21.-3
Normal Epithelial Cell-Specific 12 3     EC 3.4.218
Protease Serine-Like 12 3     EC 3.4.21.748

External Ids:    HGNC: 63581   Entrez Gene: 56552   Ensembl: ENSG000001294517   OMIM: 6026735   UniProtKB: O432403   

Export aliases for KLK10 gene to outside databases

Previous GC identifers: GC19M052148 GC19M051877 GC19M056193 GC19M056209 GC19M047848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK10 Gene:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests
that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate
cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
(provided by RefSeq, Jul 2008)

GeneCards Summary for KLK10 Gene: 
KLK10 (kallikrein-related peptidase 10) is a protein-coding gene. Diseases associated with KLK10 include lung squamous cell carcinoma, and ductal carcinoma in situ, and among its related super-pathways are Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is ENSG00000269741.

UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240
Function: Has a tumor-suppressor role for NES1 in breast and prostate cancer

Gene Wiki entry for KLK10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK10 gene promoter:
         ER-alpha   ZID   NF-E2 p45   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLK10 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLK10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13

KLK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK10 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051516:  view genomic region     (about GC identifiers)

Start:
51,515,995 bp from pter      End:
51,523,431 bp from pter
Size:
7,437 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240 (See protein sequence)
Recommended Name: Kallikrein-10 precursor  
Size: 276 amino acids; 30170 Da
Subcellular location: Secreted (Probable)
Developmental stage: Down-regulated during breast cancer progression
Secondary accessions: A6NC12 Q53YL3 Q99920 Q9GZW9

Explore the universe of human proteins at neXtProt for KLK10: NX_O43240

Explore proteomics data for KLK10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43240

  • 4 DME Specific Peptides for KLK10 (O43240)
     QGILSWG  VLTAAHC  SGGPLVC  WVLTAAH 

    KLK10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLK10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001070968.1  NP_002767.2  NP_665895.1  

    ENSEMBL proteins: 
     ENSP00000311746   ENSP00000351640   ENSP00000472773   ENSP00000471610   ENSP00000375681  

    Human Recombinant Protein Products for KLK10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KLK10
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KLK10
    GenScript Custom Purified and Recombinant Proteins Services for KLK10
    Novus Biologicals KLK10 Proteins
    Novus Biologicals KLK10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLK10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    KLK10 for ontologies           About GeneDecksing



    KLK10 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KLK10
    R&D Systems Antibodies for KLK10 (Kallikrein 10)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLK10
    GenScript Custom Superior Antibodies Services for KLK10
    Novus Biologicals KLK10 Antibodies
    Abcam antibodies for KLK10
    Cloud-Clone Corp. Antibodies for KLK10 
    ThermoFisher Antibodies for KLK10
    LSBio Antibodies in human, mouse, rat for KLK10 

    Assay Products for KLK10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLK10
    R&D Systems Proteome Profiler Antibody Arrays for KLK10 (Kallikrein 10)
    GenScript Custom Assay Services for KLK10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLK10 
    Cloud-Clone Corp. CLIAs for KLK10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KLK: Kallikreins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry O43240

    ProtoNet protein and cluster: O43240

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240
    Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
    Similarity: Contains 1 peptidase S1 domain


    KLK10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLK10_HUMAN, O43240
    Function: Has a tumor-suppressor role for NES1 in breast and prostate cancer

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.742 EC 3.4.21.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS8764136
         
    KLK10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLK10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK10 

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLK10:
    hsa-mir-224 (MIRT000454), hsa-let-7f (MIRT000455)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK10
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK10 (see all 15):
    hsa-miR-194* hsa-miR-4265 hsa-miR-582-3p hsa-miR-140-5p hsa-miR-516b* hsa-miR-646 hsa-miR-1262 hsa-miR-214
    SwitchGear 3'UTR luciferase reporter plasmidKLK10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLK10
    Sirion Biotech Customized adenovirus for overexpression of KLK10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KLK10 (see all 16)
    OriGene ORF clones in mouse, rat for KLK10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KLK10 (NM_002776)
    Sino Biological Human cDNA Clone for KLK10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK10
    Sirion Biotech Customized lentivirus for stable overexpression of KLK10 
                         Customized lentivirus expression plasmids for stable overexpression of KLK10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLK10
    Search LifeMap BioReagents cell lines for KLK10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLK10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.40
    Blood Coagulation Cascade0.39
    2MSP-RON Signaling
    MSP-RON Signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK10
        MSP-RON Signaling
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLK10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for KLK10 (O432402, 3 ENSP000003117464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRIF1Q5T3J32, 3MINT-63110 I2D: score=4 
    RIF1Q5UIP03I2D: score=1 
    BCAP31ENSP000003923304STRING: ENSP00000392330
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007049cell cycle IEA--

    KLK10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLK10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLK10

    10 Novoseek inferred chemical compound relationships for KLK10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    norgestrel 70 3 10810385 (2), 14568187 (1)
    serine 64.6 16 8372098 (1), 9647736 (1), 10775039 (1), 9809976 (1) (see all 13)
    progestins 50.6 5 14568187 (3), 10810385 (1)
    dihydrotestosterone 41.2 3 17937626 (1), 10810385 (1), 14568187 (1)
    steroid 34.1 12 14568187 (5), 10810385 (2), 10675891 (1), 17937626 (1)
    mifepristone 33.5 2 10810385 (1), 14568187 (1)
    leucine 22.6 1 18059333 (1)
    threonine 21.5 1 12438709 (1)
    estrogen 12 4 10810385 (2), 19383315 (1), 14568187 (1)
    alanine 10.6 1 18059333 (1)

    Search CenterWatch for drugs/clinical trials and news about KLK10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLK10 gene (3 alternative transcripts): 
    NM_001077500.1  NM_002776.4  NM_145888.2  

    Unigene Cluster for KLK10:

    Kallikrein-related peptidase 10
    Hs.275464  [show with all ESTs]
    Unigene Representative Sequence: NM_002776
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309958(uc002puz.3) ENST00000358789(uc002puy.3) ENST00000601467
    ENST00000599987 ENST00000599077 ENST00000391805(uc002pva.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK10
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK10 (see all 15):
    hsa-miR-194* hsa-miR-4265 hsa-miR-582-3p hsa-miR-140-5p hsa-miR-516b* hsa-miR-646 hsa-miR-1262 hsa-miR-214
    SwitchGear 3'UTR luciferase reporter plasmidKLK10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK10
    Clone
    Products:
         
    OriGene clones in human, mouse for KLK10 (see all 16)
    OriGene ORF clones in mouse, rat for KLK10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KLK10 (NM_002776)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK10
    Sirion Biotech Customized lentivirus for stable overexpression of KLK10 
                         Customized lentivirus expression plasmids for stable overexpression of KLK10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLK10
    OriGene qSTAR qPCR primer pairs in human, mouse for KLK10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK10

    Additional mRNA sequence: 

    AF024605.1 AK026045.1 AK292365.1 AK309456.1 AY561635.1 BC002710.2 CR450327.1 

    6 DOTS entries:

    DT.447393  DT.100751370  DT.40270513  DT.86853019  DT.75127791  DT.95233857 

    24/114 AceView cDNA sequences (see all 114):

    CB216785 BM783960 NM_002776 AI961896 BF515111 AA477256 AY561635 AI677641 
    AI801349 H25116 NM_145888 BM830577 AI383376 CR450327 AA582886 AA465016 
    BC002710 BE898352 AA459401 CA312154 BX283724 AA459626 BI063672 BM785939 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLK10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:        -                                             
    SP2:                                                      
    SP3:                                                      


    ECgene alternative splicing isoforms for KLK10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLK10 expression in normal human tissues (normalized intensities)      KLK10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGCTTAA
    KLK10 Expression
    About this image


    KLK10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 6 entries
             salivary gland ; glandular cells   
             buccal mucosa   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Osteochondro Mesenchymal Cells Sacral Vertebrae
             Thoracic Intervertebral Disc
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             oral mucosa ; squamous epithelial cells   
             gingival epithelium   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See KLK10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLK10

    SOURCE GeneReport for Unigene cluster: Hs.275464

    UniProtKB/Swiss-Prot: KLK10_HUMAN, O43240
    Tissue specificity: Expressed in breast, ovary and prostate

        SABiosciences Custom PCR Arrays for KLK10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLK10
    OriGene qSTAR qPCR primer pairs in human, mouse for KLK10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for KLK10 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klk101 , 5 kallikrein related-peptidase 101, 5 76.76(n)1
    68.98(a)1
      7 (28.26 cM)5
    695401  NM_133712.21  NP_598473.11 
     437810545 


    ENSEMBL Gene Tree for KLK10 (if available)
    TreeFam Gene Tree for KLK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLK10 gene
    ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  KLK92  
    KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
    PRSS32  KLK82  KLK32  
    18/39 SIMAP similar genes for KLK10 using alignment to 4 protein entries:     KLK10_HUMAN (see all proteins) (see all similar genes):
    KLK9    KLK7    KLK5    KLK12    KLK13    PRSS1
    KLK11    TRY6    TRY8    PRSS3    KLK14    KLK1
    KLK8    PRSS2    KLK15    KLK4    CFD    DF

    KLK10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 SNPs in KLK10 are shown (see all 286)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27394281,2
    C,F,H--51515545(+) ataggT/Agtgag 3 -- int113Minor allele frequency- A:0.28NA WA CSA EA 375
    rs72483421,2
    C,F,A,H--51515549(+) gagtgA/Ggccac 3 -- int15Minor allele frequency- G:0.16NA WA 244
    rs602504081,2
    C--51515558(+) ACTGCG/ACCCAG 3 -- int12Minor allele frequency- A:0.08WA 120
    rs65095101,2
    C,F,A,H--51515668(+) agtcaT/Cacagc 3 -- int122Minor allele frequency- C:0.22NS EA NA WA 2762
    rs569493521,2
    C,F--51515817(+) ATACCC/TCCTTC 3 -- int13Minor allele frequency- T:0.08WA CSA 122
    rs25694431,2
    C,F,A,H--51515833(+) CAGCAC/GTGATC 3 -- int114Minor allele frequency- G:0.35NS EA WA NA CSA 792
    rs1479179551,2
    --51515849(+) GTGTTA/GTGTGT 3 -- int10--------
    rs1420760211,2
    --51515890(+) CCGGGC/TACAAT 3 -- int10--------
    rs1854929651,2
    --51515964(+) GAAGGA/GTGACA 3 -- int10--------
    rs27394291,2
    C,F,A,H--51516015(+) tataaT/Caggtg 3 -- ut3122Minor allele frequency- C:0.38NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for KLK10 (51515995 - 51523431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLK10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677627CNV Deletion23128226
    nsv912291CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLK10
    DNA2.0 Custom Variant and Variant Library Synthesis for KLK10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602673    OMIM disorders: --

    20/24 diseases for KLK10 (see all 24):    About MalaCards
    lung squamous cell carcinoma    ductal carcinoma in situ    pancreatic ductal adenocarcinoma    peutz-jeghers syndrome
    frontotemporal dementia    prostate cancer    papillary carcinoma    testicular cancer
    lymphoblastic leukemia    gastric cancer    ovarian cancer    prostatitis
    dementia    acute lymphoblastic leukemia    squamous cell carcinoma    breast cancer
    colon cancer    colorectal cancer    alzheimer's disease    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for KLK10:
    Ovarian cancer

    KLK10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/14 Novoseek inferred disease relationships for KLK10 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 54.9 9 16557045 (3), 11920956 (2), 12727843 (2)
    breast cancer 49.6 19 9809976 (3), 10810385 (3), 11691827 (2), 11705853 (2) (see all 12)
    cancer 41.1 15 11920956 (3), 9809976 (2), 14568187 (2), 10675891 (1) (see all 8)
    carcinoma ductal 36.1 8 11705853 (3), 12788170 (2)
    prostate cancer 34.6 6 9809976 (2), 16103744 (1), 11705853 (1), 16254462 (1)
    ovarian carcinoma 33.1 4 12821340 (4)
    breast carcinoma 30.9 1 10810385 (1)
    tumors 26.8 25 12821340 (3), 16928223 (3), 11920956 (2), 12788170 (2) (see all 15)
    primary tumor 17.6 2 18485221 (1), 11691827 (1)
    gastric cancer 16.8 8 17182177 (3), 16928223 (2), 16103744 (1)

    Genetic Association Database (GAD): KLK10
    Human Genome Epidemiology (HuGE) Navigator: KLK10 (4 documents)

    Export disorders for KLK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLK10 gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with KLK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. (PubMed id 8764136)1, 2, 3, 9 Liu X.-L.... Band V. (1996)
    2. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. (PubMed id 16103744)1, 2, 9 Yousef G.M....Diamandis E.P. (2005)
    3. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. (PubMed id 11920956)1, 4, 9 Bharaj B.B....Diamandis E.P. (2002)
    4. The role for NES1 serine protease as a novel tumor suppressor. (PubMed id 9809976)1, 2, 9 Goyal J.... Band V. (1998)
    5. Structural characterization and mapping of the normal epithelial cell-specific 1 gene. (PubMed id 9647736)1, 2, 9 Luo L.-Y....Diamandis E.P. (1998)
    6. The new human kallikrein gene family: implications in carcinogenesis. (PubMed id 10675891)1, 3, 9 Diamandis E.P.... Obiezu C.V. (2000)
    7. Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1, 4 Klein R.J....Lilja H. (2010)
    8. Kallikrein-related peptidase 10 (KLK10) expression an d single nucleotide polymorphisms in ovarian cancer survival. (PubMed id 20686372)1, 4 Batra J....Spurdle A.B. (2010)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    10. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5655 HGNC: 6358 AceView: KLK10 Ensembl:ENSG00000129451 euGenes: HUgn5655
    ECgene: KLK10 H-InvDB: KLK10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLK10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLK10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLK10 gene:
    Search GeneIP for patents involving KLK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KLK10
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KLK10 (Kallikrein 10)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for KLK10 (Kallikrein 10)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLK10  
     OriGene qPCR primer pairs and template standards for KLK10   OriGene Protein Over-expression Lysate for KLK10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KLK10  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLK10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KLK10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLK10   OriGene Custom Protein Services for KLK10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLK10
     QIAGEN SeqTarget long-range PCR primers for resequencing KLK10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK10
     GenScript Custom Purified and Recombinant Proteins Services for KLK10 GenScript cDNA clones with any tag delivered in your preferred vector for KLK10
     GenScript Custom Assay Services for KLK10 GenScript Custom Superior Antibodies Services for KLK10
     GenScript Custom overexpressing Cell Line Services for KLK10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLK10 promoter
     Search Chromatin IP Primers for KLK10
     RT2 qPCR Primer Assay in human, mouse, rat KLK10
     Search GNC Networks for KLK10
     SABiosciences PCR Arrays including human, mouse, rat KLK10
     Search Tocris compounds for KLK10
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for KLK10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLK10 antibodies
     KLK10 proteins
     KLK10 lysates
     Antibodies for KLK10
     See all of Abcam's Antibodies, Kits and Proteins for KLK10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KLK10
     Antibodies for KLK10
     ELISAs for KLK10
     CLIAs for KLK10
     Search LifeMap BioReagents cell lines for KLK10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10
     SwitchGear 3'UTR luciferase reporter plasmids for KLK10
     SwitchGear Promoter luciferase reporter plasmids for KLK10
     ThermoFisher Antibodies for KLK10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KLK10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLK10
    Customized:
     lentivirus for stable overexpression of KLK10
     lentivirus expression plasmids for stable overexpression of KLK10
     adenovirus for overexpression of KLK10
     LSBio Antibodies in human, mouse, rat for KLK10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLK10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4