KLK10 Gene

Aliases
for KLK10 gene

Previous GC identifers: GC19M052148 GC19M051877 GC19M056193 GC19M056209 GC19M047848

Summaries
for KLK10 gene

Genomic Views
for KLK10 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: KLK10 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK10

KLK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051516:  view genomic region     (about GC identifiers)

Proteins
for KLK10 gene

Explore the universe of human proteins at neXtProt for KLK10: NX_O43240

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 4): KLK10 OriGene Custom Protein Services for KLK10
	GenScript Custom Purified and Recombinant Proteins Services for KLK10
	Novus Biologicals KLK10 Proteins Novus Biologicals KLK10 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KLK10

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KLK10
	R&D Systems Antibodies for KLK10 (Kallikrein 10)
	Browse OriGene Antibodies OriGene Custom Antibody Services for KLK10
	GenScript Custom Superior Antibodies Services for KLK10
	Novus Biologicals KLK10 Antibodies
	Search for Antibodies for KLK10 at Abcam
	Uscn Antibodies for KLK10
	ThermoFisher Antibodies for KLK10

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for KLK10 (Kallikrein 10)
	GenScript Custom Assay Services for KLK10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK10

Protein Domains /
Families
for KLK10 gene

ProtoNet protein and cluster: O43240

Function
for KLK10 gene

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.74² EC 3.4.21.-¹

miRNA Products:		miRTarBase miRNAs that target KLK10: hsa-mir-224 (MIRT000454), hsa-let-7f (MIRT000455)
		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK10
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KLK10 (see all 15):
		hsa-miR-194* hsa-miR-4265 hsa-miR-582-3p hsa-miR-140-5p hsa-miR-516b* hsa-miR-646 hsa-miR-1262 hsa-miR-214
		SwitchGear 3'UTR luciferase reporter plasmid: KLK10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK10 (see all 7) OriGene shRNA RFP: KLK10 OriGene siRNA: KLK10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK10

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KLK10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK10 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK10 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): KLK10 (NM_002776)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLK10
		Search LifeMap BioReagents cell lines for KLK10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for KLK10 gene

	Super-pathway	contained gene-specific pathways
1	Blood Coagulation Cascade	Blood Coagulation Cascade 1.00 Intrinsic Prothrombin Activation Pathway 0.96
2	MSP-RON Signaling	MSP-RON Signaling 1.00

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK10

	MSP-RON Signaling
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for KLK10 gene

Transcripts
for KLK10 gene

Expression
for KLK10 gene

KLK10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGGCTTAA

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneSacral VertebraeOsteochondro Mesenchymal Cells			Bone, Cartilage
	CartilageLumbar Intervertebral Disc			Cartilage
	CartilageThoracic Intervertebral Disc			Cartilage
	SomiteSacral Mesencymal Sclerotome			Somite
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLK10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10

Orthologs
for KLK10 gene

Paralogs
for KLK10 gene

Paralogs for KLK10 gene

KLK1²  KLK4²  PRSS37²  KLK11²  KLK7²  KLK14²  KLK9²  KLK12²  

KLK13²  KLK6²  KLK2²  KLK15²  KLK5²  PRSS1²  PRSS58²  PRSS3²  

KLK3²  KLK8²  

18/46 SIMAP similar genes for KLK10 using alignment to 4 protein entries:     KLK10_HUMAN (see all proteins) (see all similar genes):

KLK9    KLK13    KLK7    KLK11    KLK8    KLK5

TRY6    KLK12    TRY8    PRSS3    KLK14    KLK1

KLK15    PRSS2    PRSS1    KLK6    CFD    DF

KLK10 for paralogs           About GeneDecksing

Genomic Variants
for KLK10 gene

10/235 NCBI SNPs in KLK10 are shown (see all 235)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs27394281,2	C,F,H,	--	51515545(+)	ATAGGT/AGTGAG	3	--	int1		13		NA WA CSA EA	375
rs72483421,2	C,F,A,H,	--	51515549(+)	gagtgA/Ggccac	3	--	int1		5		NA WA	244
rs602504081,2	C,	--	51515558(+)	ACTGCG/ACCCAG	3	--	int1		2		WA	120
rs65095101,2	C,F,A,H,	--	51515668(+)	AGTCAT/CACAGC	3	--	int1		22		NS EA NA WA	2762
rs569493521,2	C,F,	--	51515817(+)	ATACCC/TCCTTC	3	--	int1		3		WA CSA	122
rs25694431,2	C,F,A,H,	--	51515833(+)	CAGCAC/GTGATC	3	--	int1		14		NS EA WA NA CSA	792
rs1479179551,2		--	51515849(+)	GTGTTA/GTGTGT	3	--	int1		0	--	--	--	--
rs1420760211,2		--	51515890(+)	CCGGGC/TACAAT	3	--	int1		0	--	--	--	--
rs1854929651,2		--	51515964(+)	GAAGGA/GTGACA	3	--	int1		0	--	--	--	--
rs27394291,2	C,F,A,H,	--	51516015(+)	TATAAT/CAGGTG	3	--	ut31		22		NS EA NA WA CSA	2350

HapMap Linkage Disequilibrium report for KLK10 (51516000 - 51523431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KLK10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK10

DNA2.0 Custom Variant and Variant Library Synthesis for KLK10

Disorders / Diseases
for KLK10 gene

20/28 diseases for KLK10

10/14 Novoseek disease relationships for KLK10 gene (see all 14)    About this table

Publications
for KLK10 gene

PubMed articles for KLK10 gene, integrated from 9 sources (see all 81): (articles sorted by number of sources associating them with KLK10)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. (PubMed id 8764136)^{1, 2, 3, 9} Liu X.-L.... Band V. (1996)
2. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. (PubMed id 16103744)^{1, 2, 9} Yousef G.M....Diamandis E.P. (2005)
3. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. (PubMed id 11920956)^{1, 4, 9} Bharaj B.B....Diamandis E.P. (2002)
4. The role for NES1 serine protease as a novel tumor suppressor. (PubMed id 9809976)^{1, 2, 9} Goyal J.... Band V. (1998)
5. Structural characterization and mapping of the normal epithelial cell-specific 1 gene. (PubMed id 9647736)^{1, 2, 9} Luo L.-Y....Diamandis E.P. (1998)
6. The new human kallikrein gene family: implications in carcinogenesis. (PubMed id 10675891)^{1, 3, 9} Diamandis E.P.... Obiezu C.V. (2000)
7. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)^{1, 3} (2006)
8. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)^{1, 3} Lundwall A....Yousef G.M. (2006)
9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

External Searches for KLK10 gene

Genome Databases showing KLK10 gene

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Products
for KLK10 gene