Aliases for KLK1 Gene
External Ids for KLK1 Gene
Previous GeneCards Identifiers for KLK1 Gene
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLK1 Gene
KLK1 (Kallikrein 1) is a Protein Coding gene. Diseases associated with KLK1 include Kallikrein, Decreased Urinary Activity Of and Shwartzman Phenomenon. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK2.
UniProtKB/Swiss-Prot for KLK1 Gene
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.