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Aliases for KLK1 Gene

Aliases for KLK1 Gene

  • Kallikrein 1 2 3
  • Kidney/Pancreas/Salivary Gland Kallikrein 3 4
  • Kallikrein 1, Renal/Pancreas/Salivary 2 3
  • Tissue Kallikrein 3 4
  • EC 4 63
  • KLKR 3 6
  • Kallikrein Serine Protease 1 3
  • Glandular Kallikrein 1 3
  • Kallikrein-1 3
  • EC 3.4.21 63
  • Klk6 3
  • HK1 3

External Ids for KLK1 Gene

Previous GeneCards Identifiers for KLK1 Gene

  • GC19M051951
  • GC19M051683
  • GC19M055998
  • GC19M056014
  • GC19M051322
  • GC19M047656

Summaries for KLK1 Gene

Entrez Gene Summary for KLK1 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK1 Gene

KLK1 (Kallikrein 1) is a Protein Coding gene. Diseases associated with KLK1 include vascular dementia and abdominal aortic aneurysm. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK1 Gene

  • Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

Gene Wiki entry for KLK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK1 Gene

Genomics for KLK1 Gene

Regulatory Elements for KLK1 Gene

Genomic Location for KLK1 Gene

50,819,146 bp from pter
50,823,787 bp from pter
4,642 bases
Minus strand

Genomic View for KLK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK1 Gene

Proteins for KLK1 Gene

  • Protein details for KLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q66US9
    • Q86U61
    • Q8TCV8
    • Q9BS53
    • Q9NQU4
    • Q9UD19
    • Q9UMJ1

    Protein attributes for KLK1 Gene

    262 amino acids
    Molecular mass:
    28890 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLK1 Gene

    Alternative splice isoforms for KLK1 Gene


neXtProt entry for KLK1 Gene

Proteomics data for KLK1 Gene at MOPED

Selected DME Specific Peptides for KLK1 Gene

Post-translational modifications for KLK1 Gene

  • The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.
  • Glycosylation at Ser93, Asn102, Ser104, Asn108, Asn165, and Ser167

Other Protein References for KLK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KLK1

Domains for KLK1 Gene

Gene Families for KLK1 Gene

Suggested Antigen Peptide Sequences for KLK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK1: view

Function for KLK1 Gene

Molecular function for KLK1 Gene

GENATLAS Biochemistry:
kallikrein 1,renal/pancreas/salivary
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage of Arg- -Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met- -Xaa or Leu- -Xaa
UniProtKB/Swiss-Prot Function:
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

Enzyme Numbers (IUBMB) for KLK1 Gene

Gene Ontology (GO) - Molecular Function for KLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 7749372
genes like me logo Genes that share ontologies with KLK1: view

Phenotypes for KLK1 Gene

genes like me logo Genes that share phenotypes with KLK1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK1 Gene

Localization for KLK1 Gene

Subcellular locations from

Jensen Localization Image for KLK1 Gene COMPARTMENTS Subcellular localization image for KLK1 gene
Compartment Confidence
nucleus 5
extracellular 3
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19232384
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KLK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLK1 Gene

Pathways for KLK1 Gene

genes like me logo Genes that share pathways with KLK1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK1: view

Drugs for KLK1 Gene

(1) Drugbank Compounds for KLK1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • bovine pancreatic trypsin inhibitor
9087-70-1 Target approved, withdrawn

(5) Novoseek inferred chemical compound relationships for KLK1 Gene

Compound -log(P) Hits PubMed IDs
kininogen 75.1 3
anthranilate 56 1
serine 51.1 6
arginine 0 1
steroid 0 1
genes like me logo Genes that share compounds with KLK1: view

Transcripts for KLK1 Gene

Unigene Clusters for KLK1 Gene

Kallikrein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5

Relevant External Links for KLK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK1 Gene

mRNA expression in normal human tissues for KLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK1 Gene

This gene is overexpressed in Pancreas (47.6).

Protein differential expression in normal tissues for KLK1 Gene

This gene is overexpressed in Urine (34.8) and Pancreatic juice (21.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KLK1 Gene

SOURCE GeneReport for Unigene cluster for KLK1 Gene Hs.123107

mRNA Expression by UniProt/SwissProt for KLK1 Gene

Tissue specificity: Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
genes like me logo Genes that share expressions with KLK1: view

Expression partners for KLK1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for KLK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLK1 35
  • 80.9 (n)
  • 72.69 (a)
-- 36
  • 26 (a)
(Canis familiaris)
Mammalia KLK1 35
  • 81.79 (n)
  • 74.62 (a)
(Rattus norvegicus)
Mammalia LOC100911764 35
  • 71.28 (n)
  • 63.08 (a)
(Mus musculus)
Mammalia Klk1 36
  • 65 (a)
Klk1b1 36
  • 62 (a)
Klk1b11 36
  • 62 (a)
Klk1b21 36
  • 59 (a)
Klk1b22 36
  • 61 (a)
Klk1b24 36
  • 59 (a)
Klk1b26 36
  • 59 (a)
Klk1b27 36
  • 59 (a)
Klk1b4 36
  • 62 (a)
Klk1b5 36
  • 64 (a)
Klk1b8 36
  • 59 (a)
Klk1b9 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
Species with no ortholog for KLK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK1 Gene

Gene Tree for KLK1 (if available)
Gene Tree for KLK1 (if available)

Paralogs for KLK1 Gene Pseudogenes for KLK1 Gene

genes like me logo Genes that share paralogs with KLK1: view

Variants for KLK1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KLK1 Gene

Genetic variations in KLK1 are the cause of a decreased in urinary kallikrein activity [MIM:615953]. The His-77 mutation dramatically reduces the activity of the enzyme in the urine. There is a 50 to 60% reduction in urinary kallikrein activity in His-77 individuals, but renal and hormonal adaptation to dietary changes in sodium and potassium are unaffected. However, in studies of brachial artery function, His-77 individuals consistently exhibited an increase in wall shear stress and a paradoxical reduction in artery diameter and lumen compared to Arg-77 individuals. This partial genetic deficiency in kallikrein activity is associated with a form of arterial dysfunction involving inappropriate inward remodeling of the brachial artery despite a chronic increase in shear stress.

Sequence variations from dbSNP and Humsavar for KLK1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs5514 -- 50,824,277(-) TGAAG(G/T)CCAAG upstream-variant-2KB
rs5515 Pathogenic, - 50,820,420(-) GGGTC(A/G)CCACA missense, reference, utr-variant-5-prime
rs5516 - 50,820,217(-) CCACC(C/G)AGGAA missense, reference
rs5517 - 50,819,976(-) AGTGC(A/G)AAAAA reference, missense
rs5518 - 50,819,954(-) GAAGG(A/C/T)GACAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KLK1 Gene

Variant ID Type Subtype PubMed ID
dgv3977n71 CNV Loss 21882294
dgv203n21 CNV Loss 19592680
dgv204n21 CNV Loss 19592680

Relevant External Links for KLK1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for KLK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KLK1 Gene in MalaCards »

(2) Diseases for KLK1 Gene

(2) University of Copenhagen DISEASES for KLK1 Gene

(4) Novoseek inferred disease relationships for KLK1 Gene

Disease -log(P) Hits PubMed IDs
cancer 16.8 3
ovarian cancer 6.6 1
renal failure chronic 0.414 2
tumors 0 1

Relevant External Links for KLK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLK1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for KLK1 Gene

Publications for KLK1 Gene

  1. Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker. (PMID: 1684954) Richards R.I. … Shaw D. (Genomics 1991) 2 3 23
  2. Significance of the tissue kallikrein promoter and transforming growth factor-beta1 polymorphisms with renal progression in children with vesicoureteral reflux. (PMID: 15086490) Lee-Chen G.J. … Lin C.Y. (Kidney Int. 2004) 3 23 48
  3. Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity. (PMID: 11912256) Slim R. … Alhenc-Gelas F. (J. Am. Soc. Nephrol. 2002) 3 4 48
  4. KLK1 gene polymorphisms are not associated with lupus nephritis in a Chinese Han population. (PMID: 20516044) Zhou X.J. … Zhang H. (J. Rheumatol. 2010) 3 23 48
  5. A coding polymorphism of the kallikrein 1 gene is associated with essential hypertension: a tagging SNP-based association study in a Chinese Han population. (PMID: 17762646) Zhao W. … Gu D. (J. Hypertens. 2007) 3 23 48

Products for KLK1 Gene

Sources for KLK1 Gene

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