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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL9 Gene

protein-coding   GIFtS: 56
GCID: GC09M021329

Kelch-Like Family Member 9

(Previous name: kelch-like 9 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 91 2
Kelch-Like 9 (Drosophila)1
Kelch-Like 92
Kelch-Like Protein 92
KIAA13543

External Ids:    HGNC: 187321   Entrez Gene: 559582   Ensembl: ENSG000001986427   OMIM: 6112015   UniProtKB: Q9P2J33   

Export aliases for KLHL9 gene to outside databases

Previous GC identifers: GC00U991232 GC09U900612 GC09M021322


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL9 Gene: 
KLHL9 (kelch-like family member 9) is a protein-coding gene. Diseases associated with KLHL9 include familial melanoma, and myopathy, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is KLHL42.

UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the
ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates
faithful mitotic progression and completion of cytokinesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL9 gene promoter:
         SRF   Bach1   AP-1   Brachyury   SRF (504 AA)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Egr-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KLHL9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

KLHL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL9 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021329:  view genomic region     (about GC identifiers)

Start:
21,329,670 bp from pter      End:
21,335,429 bp from pter
Size:
5,760 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3 (See protein sequence)
Recommended Name: Kelch-like protein 9  
Size: 617 amino acids; 69429 Da
Subunit: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13
and RBX1. Interacts with AURKB
Sequence caution: Sequence=BAA92592.1; Type=Erroneous initiation;
Secondary accessions: Q8TCQ2

Explore the universe of human proteins at neXtProt for KLHL9: NX_Q9P2J3

Explore proteomics data for KLHL9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2J3

  • KLHL9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL9 Protein Expression
    REFSEQ proteins: NP_061335.1  
    ENSEMBL proteins: 
     ENSP00000351933   ENSP00000437733  
    Reactome Protein details: Q9P2J3
    Human Recombinant Protein Products for KLHL9: 
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    Novus Biologicals KLHL9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHL9 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030496midbody IDA19995937
    GO:0031463Cul3-RING ubiquitin ligase complex IDA17543862

    KLHL9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9P2J3

    ProtoNet protein and cluster: Q9P2J3

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLHL9_HUMAN, Q9P2J3
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
    mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the
    ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates
    faithful mitotic progression and completion of cytokinesis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA17543862
    GO:0005515protein binding ----
         
    KLHL9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL9 

    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL9 (see all 32):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-4272 hsa-miR-218-1* hsa-miR-29a hsa-miR-1276 hsa-miR-133a hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidKLHL9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLHL9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Aurora B signaling
    Aurora B signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KLHL9
        Aurora B signaling

    4        Reactome Pathways for KLHL9
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for KLHL9):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3
    Pathway: Protein modification; protein ubiquitination


    KLHL9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for KLHL9 (Q9P2J32, 3 ENSP000003519334) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-51237 I2D: score=1 STRING: ENSP00000332973
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    KLHL13Q9P2N73, ENSP000002628204I2D: score=2 STRING: ENSP00000262820
    AURKBQ96GD43, ENSP000003139504I2D: score=1 STRING: ENSP00000313950
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP17543862
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IDA17543862

    KLHL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL9

    Search CenterWatch for drugs/clinical trials and news about KLHL9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL9 gene (2 alternative transcripts): 
    NM_001040713.1  NM_018847.2  

    Unigene Clusters for KLHL9:

    Kelch-like family member 9
    Hs.701778  [show with all ESTs], Hs.710126  [show with all ESTs], Hs.744736
    Unigene Representative Sequences: NM_018847, N99347, BX538121
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359039(uc003zoy.3) ENST00000537938(uc003zow.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL9
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL9 (see all 32):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-4272 hsa-miR-218-1* hsa-miR-29a hsa-miR-1276 hsa-miR-133a hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidKLHL9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL9
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL9
    Sirion Biotech Customized lentivirus for stable overexpression of KLHL9 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL9

    Additional mRNA sequence: BX538121.1 

    10 DOTS entries:

    DT.217743  DT.75100139  DT.217744  DT.100803107  DT.91715218  DT.97825105  DT.121197336  DT.91743216 
    DT.95349381  DT.121197337 

    23 AceView cDNA sequences:

    BC064958 AW138594 AA699696 AI078353 AA704225 BU190354 AW206262 BX538121 
    BF478020 CD102784 BU155043 AA280103 BI964221 W90078 AW134892 AL119197 
    W90028 AI244737 AW965504 W90156 BG178230 BU506895 W90204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL9 expression in normal human tissues (normalized intensities)      KLHL9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATCAGGA
    KLHL9 Expression
    About this image


    KLHL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             superior temporal gyrus   
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Lower Urinary Tract (Urinary System)
             visceral organ/urogenital sinus/nerves of urogenital sinus   

    See KLHL9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL9

    SOURCE GeneReport for Unigene clusters: Hs.701778 Hs.710126 Hs.744736
        SABiosciences Expression via Pathway-Focused PCR Array including KLHL9: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL9 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl91 , 5 kelch-like 9 (Drosophila)1, 5 91.57(n)1
    98.7(a)1
      4 (42.02 cM)5
    2425211  NM_172871.21  NP_766459.21 
     887182925 
    chicken
    (Gallus gallus)
    Aves KLHL131 kelch-like 9 (Drosophila) 85.75(n)
    95.76(a)
      422226  NM_001031116.1  NP_001026287.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    90(a)
    1 → many
    GL343403.1(203973-276002)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.316792 Xenopus laevis transcribed sequence with strong similarity more 81.53(n)    48051931 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc15b072 wufc15b07 77.66(n)   323951  BI984479.1 


    ENSEMBL Gene Tree for KLHL9 (if available)
    TreeFam Gene Tree for KLHL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL9 gene
    KLHL422  KLHL132  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  
    KLHL322  KLHL142  KLHL152  KLHL362  KLHDC7B2  KLHL332  KLHDC7A2  
    18/22 SIMAP similar genes for KLHL9 using alignment to 2 protein entries:     KLHL9_HUMAN (see all proteins) (see all similar genes):
    DKFZp686L0695    KLHL13    KLHL26    KBTBD3    KLHL36    KLHL31
    KLHL15    KLHL20    KLHL4    KLHL5    KLHL1    KLHL22
    KLHL14    KLHL17    KLHL2    KLHL28    KLHL12    KLHL3

    KLHL9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/178 SNPs in KLHL9 are shown (see all 178)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78724791,2
    C,F,A--21330522(+) GGGTGG/TGTGAA 1 -- ds5001 ese39Minor allele frequency- T:0.30NA WA CSA EA 368
    rs1160078561,2
    C,F--21330552(+) GATAGA/GGCAGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1475425121,2
    C--21330765(+) TAAAAA/GTACAA 1 -- ds50010--------
    rs2018393991,2
    C--21330920(+) GTCTC-/AAAAAA 1 -- ds50010--------
    rs1867360961,2
    --21330995(+) ATTGAA/GGGAAG 1 -- ds50010--------
    rs87291,2
    C,F,O,A,H--21331119(-) GATCAG/AATGTT 1 -- ut31 ese327Minor allele frequency- A:0.34MN NS EA NA WA CSA 3143
    rs1907701361,2
    --21331364(+) TTGTAC/TGGGCA 1 -- ut310--------
    rs778953511,2
    C,F--21331370(+) GGGCAG/ATAAGG 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1822929251,2
    --21331433(+) GGGATC/TGTCAA 1 -- ut310--------
    rs2022120201,2
    C--21331492(+) AGGGGG/TTTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL9 (21329670 - 21335429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLHL9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv892724CNV Gain21882294
    nsv892736CNV Gain21882294


    Human Gene Mutation Database (HGMD): KLHL9
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611201    OMIM disorders: --

    3 diseases for KLHL9:    About MalaCards
    familial melanoma    myopathy    melanoma


    KLHL9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL9
    Human Genome Epidemiology (HuGE) Navigator: KLHL9 (1 document)

    Export disorders for KLHL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL9 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with KLHL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (2010)
    2. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PubMed id 19995937)1, 2 Maerki S....Peter M. (2009)
    3. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. (PubMed id 17543862)1, 2 Sumara I....Peter M. (2007)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    5. Ubiquitylation-dependent localization of PLK1 in mitosis. (PubMed id 23455478)1 Beck J.... Sumara I. (2013)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. (PubMed id 20554658)1 Cirak S....Voit T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55958 HGNC: 18732 AceView: KLHL9 Ensembl:ENSG00000198642 euGenes: HUgn55958
    ECgene: KLHL9 Kegg: 55958 H-InvDB: KLHL9

    (According to HUGE)
    About This Section
    HUGE: KIAA1354

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL9 gene:
    Search GeneIP for patents involving KLHL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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