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KLHL9 Gene

protein-coding   GIFtS: 54
GCID: GC09M021329

Kelch-Like Family Member 9

(Previous name: kelch-like 9 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 91 2
KIAA13543 5
Kelch-Like 9 (Drosophila)1
Kelch-Like 92
Kelch-Like Protein 92

External Ids:    HGNC: 187321   Entrez Gene: 559582   Ensembl: ENSG000001986427   OMIM: 6112015   UniProtKB: Q9P2J33   

Export aliases for KLHL9 gene to outside databases

Previous GC identifers: GC00U991232 GC09U900612 GC09M021322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL9 Gene:
KLHL9 (kelch-like family member 9) is a protein-coding gene. Diseases associated with KLHL9 include familial melanoma, and cutaneous malignant melanoma. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is KLHL42.

UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the
ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates
faithful mitotic progression and completion of cytokinesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL9 gene promoter:
         SRF   Bach1   AP-1   Brachyury   SRF (504 AA)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Egr-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KLHL9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

KLHL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL9 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021329:  view genomic region     (about GC identifiers)

Start:
21,329,670 bp from pter      End:
21,335,429 bp from pter
Size:
5,760 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3 (See protein sequence)
Recommended Name: Kelch-like protein 9  
Size: 617 amino acids; 69429 Da
Subunit: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13
and RBX1. Interacts with AURKB
Sequence caution: Sequence=BAA92592.1; Type=Erroneous initiation;
Secondary accessions: Q8TCQ2

Explore the universe of human proteins at neXtProt for KLHL9: NX_Q9P2J3

Explore proteomics data for KLHL9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys171, Lys378
  • Modification sites at PhosphoSitePlus

  • See KLHL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061335.1  
    ENSEMBL proteins: 
     ENSP00000351933   ENSP00000437733  
    Reactome Protein details: Q9P2J3

    KLHL9 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KLHL9
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    Novus Biologicals KLHL9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHL9

    KLHL9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for KLHL9
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    ThermoFisher Antibody for KLHL9
    LSBio Antibodies in human, mouse, rat for KLHL9

    KLHL9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for KLHL9
    Cloud-Clone Corp. CLIAs for KLHL9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9P2J3

    ProtoNet protein and cluster: Q9P2J3

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLHL9_HUMAN, Q9P2J3
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
    mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the
    ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates
    faithful mitotic progression and completion of cytokinesis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA17543862
    GO:0005515protein binding ----
         
    KLHL9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHL9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL9

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHL9:
    hsa-mir-330-5p (MIRT038249)

    Block miRNA regulation of human, mouse, rat KLHL9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL9 (see all 32):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-4272 hsa-miR-218-1* hsa-miR-29a hsa-miR-1276 hsa-miR-133a hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidKLHL9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLHL9
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL9

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for KLHL9 (see all 6)
    OriGene ORF clones in mouse, rat for KLHL9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL9 (NM_018847)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL9

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030496midbody IDA19995937
    GO:0031463Cul3-RING ubiquitin ligase complex IDA17543862

    KLHL9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLHL9 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Aurora B signaling
    Aurora B signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KLHL9
        Aurora B signaling

    1 Reactome Pathway for KLHL9
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for KLHL9):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: KLHL9_HUMAN, Q9P2J3
    Pathway: Protein modification; protein ubiquitination


    KLHL9 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KLHL9: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KLHL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for KLHL9 (Q9P2J32, 3 ENSP000003519334) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-51237 I2D: score=1 STRING: ENSP00000332973
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    KLHL13Q9P2N73, ENSP000002628204I2D: score=2 STRING: ENSP00000262820
    AURKBQ96GD43, ENSP000003139504I2D: score=1 STRING: ENSP00000313950
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP17543862
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IDA17543862

    KLHL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLHL9 gene (2 alternative transcripts): 
    NM_001040713.1  NM_018847.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359039(uc003zoy.3) ENST00000537938(uc003zow.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHL9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL9 (see all 32):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-4272 hsa-miR-218-1* hsa-miR-29a hsa-miR-1276 hsa-miR-133a hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidKLHL9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLHL9
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL9
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL9 (see all 6)
    OriGene ORF clones in mouse, rat for KLHL9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL9 (NM_018847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL9
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLHL9
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL9
      QuantiTect SYBR Green Assays in human, mouse, rat KLHL9
      QuantiFast Probe-based Assays in human, mouse, rat KLHL9

    23 AceView cDNA sequences:

    AW206262 BC064958 AI078353 AA704225 BU190354 AA699696 AW138594 BF478020 
    BU155043 BX538121 W90078 AA280103 BI964221 AW134892 AL119197 CD102784 
    AI244737 AW965504 W90156 W90028 W90204 BG178230 BU506895 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATCAGGA
    KLHL9 Expression
    About this image


    KLHL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
    KLHL9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL9 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including KLHL9: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLHL9
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL9
    QuantiTect SYBR Green Assays in human, mouse, rat KLHL9
    QuantiFast Probe-based Assays in human, mouse, rat KLHL9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL9 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl91 , 5 kelch-like 9 (Drosophila)5
    kelch-like 91
    91.57(n)1
    98.7(a)1
      4 (42.02 cM)5
    2425211  NM_172871.21  NP_766459.21 
     887182925 
    chicken
    (Gallus gallus)
    Aves KLHL131 kelch-like 9 (Drosophila) 85.75(n)
    95.76(a)
      422226  NM_001031116.1  NP_001026287.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    90(a)
    1 → many
    GL343403.1(203973-276002)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.316792 Xenopus laevis transcribed sequence with strong similarity more 81.53(n)    48051931 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc15b072 wufc15b07 77.66(n)   323951  BI984479.1 


    ENSEMBL Gene Tree for KLHL9 (if available)
    TreeFam Gene Tree for KLHL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL9 gene
    KLHL422  KLHL132  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  
    KLHL322  KLHL142  KLHL152  KLHL362  KLHDC7B2  KLHL332  KLHDC7A2  
    Selected SIMAP similar genes for KLHL9 using alignment to 2 protein entries:     KLHL9_HUMAN (see all proteins) (see all similar genes):
    DKFZp686L0695    KLHL13    KLHL26    KBTBD3    KLHL36    KLHL31
    KLHL15    KLHL20    KLHL4    KLHL5    KLHL1    KLHL22
    KLHL14    KLHL17    KLHL2    KLHL28    KLHL12    KLHL3

    KLHL9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL9 (see all 178)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78724791,2
    C,F,A--21330522(+) GGGTGG/TGTGAA 1 -- ds5001 ese39Minor allele frequency- T:0.30NA WA CSA EA 368
    rs1160078561,2
    C,F--21330552(+) GATAGA/GGCAGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1475425121,2
    C--21330765(+) TAAAAA/GTACAA 1 -- ds50010--------
    rs2018393991,2
    C--21330920(+) GTCTC-/AAAAAA 1 -- ds50010--------
    rs1867360961,2
    --21330995(+) ATTGAA/GGGAAG 1 -- ds50010--------
    rs87291,2
    C,F,O,A,H--21331119(-) GATCAG/AATGTT 1 -- ut31 ese327Minor allele frequency- A:0.34MN NS EA NA WA CSA 3143
    rs1907701361,2
    --21331364(+) TTGTAC/TGGGCA 1 -- ut310--------
    rs778953511,2
    C,F--21331370(+) GGGCAG/ATAAGG 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1822929251,2
    --21331433(+) GGGATC/TGTCAA 1 -- ut310--------
    rs2022120201,2
    C--21331492(+) AGGGGG/TTTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL9 (21329670 - 21335429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLHL9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv892724CNV Gain21882294
    nsv892736CNV Gain21882294

    Human Gene Mutation Database (HGMD): KLHL9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL9
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611201    OMIM disorders: --

    5 diseases for KLHL9:    
    About MalaCards
    familial melanoma    cutaneous malignant melanoma    myopathy    sinusitis
    melanoma


    KLHL9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL9
    Human Genome Epidemiology (HuGE) Navigator: KLHL9 (1 document)

    Export disorders for KLHL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL9 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with KLHL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
    2. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PubMed id 19995937)1, 2 Maerki S.... Peter M. (J. Cell Biol. 2009)
    3. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. (PubMed id 17543862)1, 2 Sumara I....Peter M. (Dev. Cell 2007)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    6. Ubiquitylation-dependent localization of PLK1 in mitosis. (PubMed id 23455478)1 Beck J.... Sumara I. (Nat. Cell Biol. 2013)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55958 HGNC: 18732 AceView: KLHL9 Ensembl:ENSG00000198642 euGenes: HUgn55958
    ECgene: KLHL9 Kegg: 55958 H-InvDB: KLHL9

    (According to HUGE)
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    HUGE: KIAA1354

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLHL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL9 gene:
    Search GeneIP for patents involving KLHL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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