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Aliases for KLHL9 Gene

Aliases for KLHL9 Gene

  • Kelch-Like Family Member 9 2 3
  • KIAA1354 4 6
  • Kelch-Like 9 (Drosophila) 2

External Ids for KLHL9 Gene

Previous GeneCards Identifiers for KLHL9 Gene

  • GC00U991232
  • GC09U900612
  • GC09M021322

Summaries for KLHL9 Gene

GeneCards Summary for KLHL9 Gene

KLHL9 (Kelch-Like Family Member 9) is a Protein Coding gene. Diseases associated with KLHL9 include klhl9-related childhood-onset distal myopathy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL9 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL9 Gene

Genomics for KLHL9 Gene

Regulatory Elements for KLHL9 Gene

Genomic Location for KLHL9 Gene

Start:
21,329,671 bp from pter
End:
21,335,430 bp from pter
Size:
5,760 bases
Orientation:
Minus strand

Genomic View for KLHL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL9 Gene

Proteins for KLHL9 Gene

  • Protein details for KLHL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2J3-KLHL9_HUMAN
    Recommended name:
    Kelch-like protein 9
    Protein Accession:
    Q9P2J3
    Secondary Accessions:
    • Q8TCQ2

    Protein attributes for KLHL9 Gene

    Size:
    617 amino acids
    Molecular mass:
    69429 Da
    Quaternary structure:
    • Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.
    SequenceCaution:
    • Sequence=BAA92592.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KLHL9 Gene

Proteomics data for KLHL9 Gene at MOPED

Post-translational modifications for KLHL9 Gene

  • Ubiquitination at Lys171 and Lys378
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL9 Gene

Domains for KLHL9 Gene

Gene Families for KLHL9 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2J3

UniProtKB/Swiss-Prot:

KLHL9_HUMAN :
  • Q9P2J3
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL9: view

Function for KLHL9 Gene

Molecular function for KLHL9 Gene

UniProtKB/Swiss-Prot Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Gene Ontology (GO) - Molecular Function for KLHL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 17543862
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL9: view

miRNA for KLHL9 Gene

miRTarBase miRNAs that target KLHL9

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL9 Gene

Localization for KLHL9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL9 Gene COMPARTMENTS Subcellular localization image for KLHL9 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030496 midbody IDA 19995937
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 17543862
genes like me logo Genes that share ontologies with KLHL9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL9 Gene

Pathways for KLHL9 Gene

genes like me logo Genes that share pathways with KLHL9: view

Pathways by source for KLHL9 Gene

UniProtKB/Swiss-Prot Q9P2J3-KLHL9_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KLHL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 17543862
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL9: view

Transcripts for KLHL9 Gene

mRNA/cDNA for KLHL9 Gene

(23) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL9 Gene

No ASD Table

Relevant External Links for KLHL9 Gene

GeneLoc Exon Structure for
KLHL9
ECgene alternative splicing isoforms for
KLHL9

Expression for KLHL9 Gene

mRNA expression in normal human tissues for KLHL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL9 Gene

SOURCE GeneReport for Unigene cluster for KLHL9 Gene Hs.701778

genes like me logo Genes that share expressions with KLHL9: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL9 Gene

Orthologs for KLHL9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL9 35
  • 99.84 (n)
  • 100 (a)
KLHL9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL9 35
  • 94.38 (n)
  • 99.68 (a)
KLHL9 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100688162 35
  • 92.44 (n)
  • 99.51 (a)
mouse
(Mus musculus)
Mammalia Klhl9 35
  • 91.57 (n)
  • 98.7 (a)
Klhl9 16
Klhl9 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Klhl9 35
  • 91.95 (n)
  • 99.19 (a)
chicken
(Gallus gallus)
Aves KLHL13 35
  • 85.75 (n)
  • 95.76 (a)
KLHL13 36
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.31679 35
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl13 35
  • 81.51 (n)
  • 93.96 (a)
zebrafish
(Danio rerio)
Actinopterygii klhl13 35
  • 74.55 (n)
  • 91.03 (a)
klhl13 36
  • 91 (a)
OneToMany
wufc15b07 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6929 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KLHL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL9 Gene

ENSEMBL:
Gene Tree for KLHL9 (if available)
TreeFam:
Gene Tree for KLHL9 (if available)

Paralogs for KLHL9 Gene

genes like me logo Genes that share paralogs with KLHL9: view

Variants for KLHL9 Gene

Sequence variations from dbSNP and Humsavar for KLHL9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8729 -- 21,331,120(-) GATCA(A/G)ATGTT utr-variant-3-prime
rs7863385 -- 21,335,405(+) ATACC(A/C)CGGGG utr-variant-5-prime
rs7863622 -- 21,335,538(+) CGGAG(C/T)TGTGT upstream-variant-2KB
rs7872479 -- 21,330,523(+) GGGTG(G/T)GTGAA downstream-variant-500B
rs10119659 -- 21,331,507(+) GTGTA(A/T)TACAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL9 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892736 CNV Gain 21882294

Relevant External Links for KLHL9 Gene

HapMap Linkage Disequilibrium report
KLHL9
Human Gene Mutation Database (HGMD)
KLHL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL9 Gene

Disorders for KLHL9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KLHL9 Gene including...

Search for KLHL9 Gene in MalaCards »

Relevant External Links for KLHL9

Genetic Association Database (GAD)
KLHL9
Human Genome Epidemiology (HuGE) Navigator
KLHL9
genes like me logo Genes that share disorders with KLHL9: view

No data available for UniProtKB/Swiss-Prot for KLHL9 Gene

Publications for KLHL9 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. (PMID: 17543862) Sumara I. … Peter M. (Dev. Cell 2007) 3 4
  3. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 48
  4. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PMID: 19995937) Maerki S. … Peter M. (J. Cell Biol. 2009) 3 4
  5. Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. (PMID: 20554658) Cirak S. … Voit T. (Brain 2010) 3

Products for KLHL9 Gene

Sources for KLHL9 Gene

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