Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL6 Gene

Aliases for KLHL6 Gene

  • Kelch Like Family Member 6 2 3 5
  • Kelch-Like 6 (Drosophila) 2
  • Kelch-Like Protein KLHL6 2

External Ids for KLHL6 Gene

Previous GeneCards Identifiers for KLHL6 Gene

  • GC03M179980
  • GC03M184061
  • GC03M184607
  • GC03M184526
  • GC03M184688
  • GC03M183205
  • GC03M180611

Summaries for KLHL6 Gene

GeneCards Summary for KLHL6 Gene

KLHL6 (Kelch Like Family Member 6) is a Protein Coding gene. An important paralog of this gene is KLHL24.

UniProtKB/Swiss-Prot for KLHL6 Gene

  • Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL6 Gene

Genomics for KLHL6 Gene

Regulatory Elements for KLHL6 Gene

Enhancers for KLHL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F183507 0.8 FANTOM5 33.4 +48.5 48534 0.3 ATF3 IKZF1 KLHL6 B3GNT5 YEATS2 MCF2L2 KLHL24 ENSG00000271682 KLHL6-AS1
GH03F183508 0.9 FANTOM5 33.3 +46.7 46699 0.2 IKZF1 KLHL6 B3GNT5 YEATS2 MCF2L2 KLHL24 KLHL6-AS1 ENSG00000271682
GH03F183527 1 FANTOM5 ENCODE 30.5 +27.8 27811 1.6 HDGF MXI1 TBL1XR1 WRNIP1 JUN SIN3A YBX1 BMI1 EBF1 YY1 KLHL6 B3GNT5 KLHL24 ENSG00000199363 ENSG00000251730 ENSG00000201229 ENSG00000253092 LINC00888 YEATS2 KLHL6-AS1
GH03F183510 1.7 FANTOM5 Ensembl ENCODE 29.4 +41.6 41614 6.2 HDGF TBP PKNOX1 SIN3A YBX1 ZBTB40 SCRT2 ETV6 CREM USF2 KLHL6 B3GNT5 KLHL24 YEATS2 ENSG00000251730 ENSG00000199363 ENSG00000201229 ENSG00000253092 LINC00888 MCF2L2
GH03F183552 0.6 FANTOM5 ENCODE 23.9 +0.9 932 5.5 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ZNF143 JUNB TBX21 SMARCB1 KLHL6 B3GNT5 EIF2B5 RPS3P3 KLHL24 KLHL6-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KLHL6 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381152 1012 2601 PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ZNF143 JUNB TBX21 SMARCB1 SMARCA4

Genomic Location for KLHL6 Gene

Chromosome:
3
Start:
183,487,531 bp from pter
End:
183,555,712 bp from pter
Size:
68,182 bases
Orientation:
Minus strand

Genomic View for KLHL6 Gene

Genes around KLHL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL6 Gene

Proteins for KLHL6 Gene

  • Protein details for KLHL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ60-KLHL6_HUMAN
    Recommended name:
    Kelch-like protein 6
    Protein Accession:
    Q8WZ60
    Secondary Accessions:
    • B2RB31
    • D3DNS8
    • Q8N5I1
    • Q8N892

    Protein attributes for KLHL6 Gene

    Size:
    621 amino acids
    Molecular mass:
    70359 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32348.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL35594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37078.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KLHL6 Gene

Post-translational modifications for KLHL6 Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL6 Gene

No data available for DME Specific Peptides for KLHL6 Gene

Domains & Families for KLHL6 Gene

Gene Families for KLHL6 Gene

Suggested Antigen Peptide Sequences for KLHL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ60

UniProtKB/Swiss-Prot:

KLHL6_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL6: view

Function for KLHL6 Gene

Molecular function for KLHL6 Gene

UniProtKB/Swiss-Prot Function:
Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Gene Ontology (GO) - Molecular Function for KLHL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLHL6: view
genes like me logo Genes that share phenotypes with KLHL6: view

Animal Models for KLHL6 Gene

MGI Knock Outs for KLHL6:

Animal Model Products

miRNA for KLHL6 Gene

miRTarBase miRNAs that target KLHL6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL6 Gene

Localization for KLHL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL6 Gene COMPARTMENTS Subcellular localization image for KLHL6 gene
Compartment Confidence
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL6 Gene

Pathways & Interactions for KLHL6 Gene

SuperPathways for KLHL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002467 germinal center formation IEA --
GO:0050853 B cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with KLHL6: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL6 Gene

Transcripts for KLHL6 Gene

Unigene Clusters for KLHL6 Gene

Kelch-like family member 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - -
SP6:

Relevant External Links for KLHL6 Gene

GeneLoc Exon Structure for
KLHL6
ECgene alternative splicing isoforms for
KLHL6

Expression for KLHL6 Gene

mRNA expression in normal human tissues for KLHL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL6 Gene

This gene is overexpressed in Whole Blood (x8.7), Spleen (x6.1), and Small Intestine - Terminal Ileum (x5.2).

Protein differential expression in normal tissues from HIPED for KLHL6 Gene

This gene is overexpressed in Prostate (49.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL6 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLHL6 Gene:

KLHL6

SOURCE GeneReport for Unigene cluster for KLHL6 Gene:

Hs.659147

mRNA Expression by UniProt/SwissProt for KLHL6 Gene:

Q8WZ60-KLHL6_HUMAN
Tissue specificity: Found in germinal center B-cells.
genes like me logo Genes that share expression patterns with KLHL6: view

Primer Products

No data available for Protein tissue co-expression partners for KLHL6 Gene

Orthologs for KLHL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL6 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia KLHL6 34 35
  • 91.71 (n)
dog
(Canis familiaris)
Mammalia KLHL6 34 35
  • 91.36 (n)
mouse
(Mus musculus)
Mammalia Klhl6 34 16 35
  • 87.88 (n)
rat
(Rattus norvegicus)
Mammalia Klhl6 34
  • 87.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL6 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL6 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL6 34 35
  • 77.38 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL6 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl6 34
  • 70.27 (n)
zebrafish
(Danio rerio)
Actinopterygii klhl6 34 35
  • 67.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for KLHL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL6 Gene

ENSEMBL:
Gene Tree for KLHL6 (if available)
TreeFam:
Gene Tree for KLHL6 (if available)

Paralogs for KLHL6 Gene

(20) SIMAP similar genes for KLHL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL6: view

Variants for KLHL6 Gene

Sequence variations from dbSNP and Humsavar for KLHL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs548549593 Uncertain significance 183,555,386(+) GGCAA(A/C/G)CACCA nc-transcript-variant, reference, missense
rs748341250 Uncertain significance 183,555,407(+) GGAGA(A/C)TTCCT nc-transcript-variant, reference, missense
rs1001190 -- 183,493,184(-) CCTCA(A/G)TGCTG intron-variant, utr-variant-3-prime
rs10451931 -- 183,545,850(+) ATTTT(A/G/T)TCATC intron-variant
rs10451932 -- 183,546,743(+) TGAAT(C/T)CATTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHL6 Gene

Variant ID Type Subtype PubMed ID
esv1009906 CNV insertion 20482838
esv1042642 CNV insertion 17803354
esv2672458 CNV deletion 23128226
esv3302650 CNV tandem duplication 20981092
esv3332131 CNV duplication 20981092
esv3569147 CNV loss 25503493
esv3569148 CNV loss 25503493
esv3598924 CNV gain 21293372
esv3598925 CNV loss 21293372
esv3598926 CNV loss 21293372
nsv1006872 CNV loss 25217958
nsv1133329 CNV tandem duplication 24896259
nsv4144 CNV deletion 18451855
nsv475203 CNV novel sequence insertion 20440878
nsv477028 CNV novel sequence insertion 20440878

Variation tolerance for KLHL6 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL6 Gene

Human Gene Mutation Database (HGMD)
KLHL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL6 Gene

Disorders for KLHL6 Gene

Relevant External Links for KLHL6

Genetic Association Database (GAD)
KLHL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL6

No disorders were found for KLHL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL6 Gene

Publications for KLHL6 Gene

  1. Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. (PMID: 12617994) Gupta-Rossi N. … Dahan A. (Mol. Immunol. 2003) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for KLHL6 Gene

Sources for KLHL6 Gene

Content
Loading form....