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Aliases for KLHL6 Gene

Aliases for KLHL6 Gene

  • Kelch Like Family Member 6 2 3 5
  • Kelch-Like 6 (Drosophila) 2
  • Kelch-Like Protein KLHL6 2

External Ids for KLHL6 Gene

Previous GeneCards Identifiers for KLHL6 Gene

  • GC03M179980
  • GC03M184061
  • GC03M184607
  • GC03M184526
  • GC03M184688
  • GC03M183205
  • GC03M180611

Summaries for KLHL6 Gene

GeneCards Summary for KLHL6 Gene

KLHL6 (Kelch Like Family Member 6) is a Protein Coding gene. An important paralog of this gene is KBTBD4.

UniProtKB/Swiss-Prot for KLHL6 Gene

  • Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL6 Gene

Genomics for KLHL6 Gene

Regulatory Elements for KLHL6 Gene

Enhancers for KLHL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL6 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL6 Gene

183,487,531 bp from pter
183,555,712 bp from pter
68,182 bases
Minus strand

Genomic View for KLHL6 Gene

Genes around KLHL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL6 Gene

Proteins for KLHL6 Gene

  • Protein details for KLHL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 6
    Protein Accession:
    Secondary Accessions:
    • B2RB31
    • D3DNS8
    • Q8N5I1
    • Q8N892

    Protein attributes for KLHL6 Gene

    621 amino acids
    Molecular mass:
    70359 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32348.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL35594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37078.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KLHL6 Gene

Proteomics data for KLHL6 Gene at MOPED

Post-translational modifications for KLHL6 Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL6 Gene

Domains & Families for KLHL6 Gene

Gene Families for KLHL6 Gene

Suggested Antigen Peptide Sequences for KLHL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL6: view

Function for KLHL6 Gene

Molecular function for KLHL6 Gene

UniProtKB/Swiss-Prot Function:
Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Phenotypes for KLHL6 Gene

genes like me logo Genes that share phenotypes with KLHL6: view

Animal Models for KLHL6 Gene

MGI Knock Outs for KLHL6:

Animal Model Products

miRNA for KLHL6 Gene

miRTarBase miRNAs that target KLHL6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL6 Gene

Localization for KLHL6 Gene

Subcellular locations from

Jensen Localization Image for KLHL6 Gene COMPARTMENTS Subcellular localization image for KLHL6 gene
Compartment Confidence
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL6 Gene

Pathways & Interactions for KLHL6 Gene

SuperPathways for KLHL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050853 B cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with KLHL6: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL6 Gene

Drugs & Compounds for KLHL6 Gene

No Compound Related Data Available

Transcripts for KLHL6 Gene

Unigene Clusters for KLHL6 Gene

Kelch-like family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP5: - - - -

Relevant External Links for KLHL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL6 Gene

mRNA expression in normal human tissues for KLHL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL6 Gene

This gene is overexpressed in Whole Blood (x8.7), Spleen (x6.1), and Small Intestine - Terminal Ileum (x5.2).

Protein differential expression in normal tissues from HIPED for KLHL6 Gene

This gene is overexpressed in Prostate (49.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL6 Gene

SOURCE GeneReport for Unigene cluster for KLHL6 Gene Hs.659147

mRNA Expression by UniProt/SwissProt for KLHL6 Gene

Tissue specificity: Found in germinal center B-cells.
genes like me logo Genes that share expression patterns with KLHL6: view

Primer Products

No data available for Protein tissue co-expression partners for KLHL6 Gene

Orthologs for KLHL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL6 35
  • 91.71 (n)
  • 96.77 (a)
KLHL6 36
  • 97 (a)
(Canis familiaris)
Mammalia KLHL6 35
  • 91.36 (n)
  • 97.26 (a)
KLHL6 36
  • 98 (a)
(Mus musculus)
Mammalia Klhl6 35
  • 87.88 (n)
  • 94.67 (a)
Klhl6 16
Klhl6 36
  • 95 (a)
(Pan troglodytes)
Mammalia KLHL6 35
  • 99.46 (n)
  • 99.84 (a)
KLHL6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl6 35
  • 87.61 (n)
  • 94.83 (a)
(Monodelphis domestica)
Mammalia KLHL6 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL6 36
  • 84 (a)
(Gallus gallus)
Aves KLHL6 35
  • 77.38 (n)
  • 84.26 (a)
KLHL6 36
  • 84 (a)
(Anolis carolinensis)
Reptilia KLHL6 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl6 35
  • 70.27 (n)
  • 76.07 (a)
(Danio rerio)
Actinopterygii klhl6 35
  • 67.05 (n)
  • 70.89 (a)
klhl6 36
  • 70 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for KLHL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL6 Gene

Gene Tree for KLHL6 (if available)
Gene Tree for KLHL6 (if available)

Paralogs for KLHL6 Gene

(20) SIMAP similar genes for KLHL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL6: view

Variants for KLHL6 Gene

Sequence variations from dbSNP and Humsavar for KLHL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35354575 - 183,492,506(-) ACCGC(A/G)TCTAT nc-transcript-variant, reference, missense, utr-variant-3-prime
rs11075 -- 183,495,448(-) AGGTA(C/T)CCCAC intron-variant
rs1876702 -- 183,495,188(-) CTTAG(A/T)AAACC intron-variant
rs1879781 -- 183,502,696(+) gaatc(C/T)cataa intron-variant
rs1879782 -- 183,523,812(-) ACTGC(A/G)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL6 Gene

Variant ID Type Subtype PubMed ID
nsv4144 CNV Loss 18451855
nsv878049 CNV Gain 21882294
esv259624 OTHER Complex 20981092
esv1009906 CNV Insertion 20482838
esv1042642 CNV Insertion 17803354
esv2672458 CNV Deletion 23128226

Variation tolerance for KLHL6 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL6 Gene

Disorders for KLHL6 Gene

Relevant External Links for KLHL6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL6 Gene

Publications for KLHL6 Gene

  1. Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. (PMID: 12617994) Gupta-Rossi N. … Dahan A. (Mol. Immunol. 2003) 2 3 4 23 67
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KLHL6 Gene

Sources for KLHL6 Gene