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Aliases for KLHL5 Gene

Aliases for KLHL5 Gene

  • Kelch Like Family Member 5 2 3 5
  • Kelch (Drosophila)-Like 5 2
  • Kelch-Like 5 (Drosophila) 2

External Ids for KLHL5 Gene

Previous GeneCards Identifiers for KLHL5 Gene

  • GC04M038768
  • GC04M039139
  • GC04P038898
  • GC04P038886
  • GC04P038723
  • GC04P038371

Summaries for KLHL5 Gene

GeneCards Summary for KLHL5 Gene

KLHL5 (Kelch Like Family Member 5) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL5 Gene

Genomics for KLHL5 Gene

Regulatory Elements for KLHL5 Gene

Enhancers for KLHL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G038983 1.3 Ensembl ENCODE dbSUPER 16.9 -59.5 -59482 2.8 ELF3 FOXA2 ZSCAN4 THRB ZNF48 IKZF2 CREM JUNB ZEB2 NFIL3 KLHL5 TMEM156 ENSG00000249207 ENSG00000249685 FAM114A1 MIR574 RNU6-32P RFC1 RPL9 GC04P038912
GH04G039040 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -0.2 -232 8.1 HDGF PKNOX1 FOXA2 MLX WRNIP1 SIN3A ARID4B YY1 ZNF766 FOS ENSG00000249685 ZBTB12BP ENSG00000250568 KLHL5 TMEM156 TLR1 TLR6 KLF3
GH04G038948 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -95.7 -95744 2.0 JUN MAX SIN3A RAD21 YY1 FOSL1 SMC3 HNF4G FOS NFE2L2 KLHL5 RNU6-887P KLB KLF3 GC04P038912 TMEM156
GH04G038980 1 ENCODE dbSUPER 15.5 -63.3 -63333 1.6 FOXA2 TAL1 ZNF175 CEBPG FOSL1 ETV6 FOS CREM SRF ZBED1 KLHL5 ENSG00000249207 ENSG00000249685 MIR574 FAM114A1 TMEM156 GC04P038912
GH04G038989 0.7 dbSUPER 16.8 -54.5 -54462 1.1 MAX ZBTB40 RAD21 FOXA1 YY1 JUND ATF3 ZKSCAN8 HNF4G FOS KLHL5 ENSG00000249685 TMEM156 ENSG00000249207 MIR574 FAM114A1 GC04P038912
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL5 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167589 499 2201 HDGF FOXA2 WRNIP1 ARID4B YY1 ZNF121 GTF3C2 ZNF766 FOS SP3

Genomic Location for KLHL5 Gene

39,044,801 bp from pter
39,142,823 bp from pter
98,023 bases
Plus strand

Genomic View for KLHL5 Gene

Genes around KLHL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL5 Gene

Proteins for KLHL5 Gene

  • Protein details for KLHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 5
    Protein Accession:
    Secondary Accessions:
    • A8K170
    • B7WP68
    • E9PCF4
    • F8WAE7
    • G3XA92
    • Q6Y881
    • Q86XW0
    • Q9NUK3
    • Q9NV27
    • Q9NVA9
    • Q9Y2X2

    Protein attributes for KLHL5 Gene

    755 amino acids
    Molecular mass:
    84457 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD32565.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL08584.1; Type=Erroneous termination; Positions=735; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=BAA91845.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91933.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92121.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL5 Gene

neXtProt entry for KLHL5 Gene

Post-translational modifications for KLHL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLHL5 Gene

Domains & Families for KLHL5 Gene

Gene Families for KLHL5 Gene

Suggested Antigen Peptide Sequences for KLHL5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL5: view

No data available for UniProtKB/Swiss-Prot for KLHL5 Gene

Function for KLHL5 Gene

Gene Ontology (GO) - Molecular Function for KLHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL5 Gene

Localization for KLHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL5 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL5 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 3
extracellular 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KLHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 14672410
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL5: view

Pathways & Interactions for KLHL5 Gene

genes like me logo Genes that share pathways with KLHL5: view

Interacting Proteins for KLHL5 Gene

Gene Ontology (GO) - Biological Process for KLHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KLHL5: view

No data available for SIGNOR curated interactions for KLHL5 Gene

Drugs & Compounds for KLHL5 Gene

No Compound Related Data Available

Transcripts for KLHL5 Gene

Unigene Clusters for KLHL5 Gene

Kelch-like family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for KLHL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL5 Gene

This gene is overexpressed in Heart (51.6) and Prostate (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL5 Gene

Protein tissue co-expression partners for KLHL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL5 Gene:


SOURCE GeneReport for Unigene cluster for KLHL5 Gene:


mRNA Expression by UniProt/SwissProt for KLHL5 Gene:

Tissue specificity: Expressed in adrenal gland, ovary and thyroid gland and less abundantly in lymph node, prostate, spinal chord, testis and trachea.

Evidence on tissue expression from TISSUES for KLHL5 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with KLHL5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL5 Gene

Orthologs for KLHL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL5 34 35
  • 99.51 (n)
(Monodelphis domestica)
Mammalia KLHL5 35
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL5 35
  • 96 (a)
(Canis familiaris)
Mammalia KLHL5 34 35
  • 95.31 (n)
(Bos Taurus)
Mammalia KLHL5 34 35
  • 94.31 (n)
(Rattus norvegicus)
Mammalia Klhl5 34
  • 89.22 (n)
(Mus musculus)
Mammalia Klhl5 34 16 35
  • 87.57 (n)
(Gallus gallus)
Aves KLHL5 34 35
  • 82.69 (n)
(Anolis carolinensis)
Reptilia KLHL5 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl5 34
  • 77.98 (n)
(Danio rerio)
Actinopterygii klhl5 34 35
  • 69.55 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001513 34
  • 57.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17754 36 34 35
  • 54.82 (n)
CG15097 36
  • 41 (a)
CG3571 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea T27E9.4a 36
  • 33 (a)
T27E9.4b 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6119 34
Species where no ortholog for KLHL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHL5 Gene

Gene Tree for KLHL5 (if available)
Gene Tree for KLHL5 (if available)

Paralogs for KLHL5 Gene

Variants for KLHL5 Gene

Sequence variations from dbSNP and Humsavar for KLHL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000033272 -- 39,127,487(+) CTGTC(A/G)CCCAG intron-variant
rs1000048856 -- 39,052,640(+) GATAG(C/G)ATGGA intron-variant
rs1000066156 -- 39,130,532(+) GATTT(G/T)GGGGG intron-variant
rs1000112032 -- 39,079,851(+) TGAAT(C/G)GGCAG intron-variant
rs1000124415 -- 39,072,991(+) ATGAA(A/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL5 Gene

Variant ID Type Subtype PubMed ID
esv2727455 CNV deletion 23290073
esv28236 CNV gain 19812545
esv28537 CNV loss 19812545
esv3310335 CNV mobile element insertion 20981092
esv3338664 CNV insertion 20981092
nsv1073752 CNV deletion 25765185
nsv476983 CNV novel sequence insertion 20440878
nsv594013 CNV gain+loss 21841781
nsv822540 CNV gain 20364138

Variation tolerance for KLHL5 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL5 Gene

Disorders for KLHL5 Gene

Relevant External Links for KLHL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL5 Gene

Publications for KLHL5 Gene

  1. Characterization of a novel splicing variant of KLHL5, a member of the kelch protein family. (PMID: 14672410) Xu J. … Mao Y. (Mol. Biol. Rep. 2003) 2 3 4 22 64
  2. Cloning and characterization of KLHL5, a novel human gene encoding a kelch-related protein with a BTB domain. (PMID: 11590829) Wang S. … Mao Y. (Biochem. Genet. 2001) 2 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for KLHL5 Gene

Sources for KLHL5 Gene

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