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Aliases for KLHL5 Gene

Aliases for KLHL5 Gene

  • Kelch Like Family Member 5 2 3 5
  • Kelch (Drosophila)-Like 5 2
  • Kelch-Like 5 (Drosophila) 2

External Ids for KLHL5 Gene

Previous GeneCards Identifiers for KLHL5 Gene

  • GC04M038768
  • GC04M039139
  • GC04P038898
  • GC04P038886
  • GC04P038723
  • GC04P038371

Summaries for KLHL5 Gene

GeneCards Summary for KLHL5 Gene

KLHL5 (Kelch Like Family Member 5) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL5 Gene

Genomics for KLHL5 Gene

Regulatory Elements for KLHL5 Gene

Promoters for KLHL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL5 Gene

Chromosome:
4
Start:
39,044,801 bp from pter
End:
39,142,823 bp from pter
Size:
98,023 bases
Orientation:
Plus strand

Genomic View for KLHL5 Gene

Genes around KLHL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL5 Gene

Proteins for KLHL5 Gene

  • Protein details for KLHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PQ7-KLHL5_HUMAN
    Recommended name:
    Kelch-like protein 5
    Protein Accession:
    Q96PQ7
    Secondary Accessions:
    • A8K170
    • B7WP68
    • E9PCF4
    • F8WAE7
    • G3XA92
    • Q6Y881
    • Q86XW0
    • Q9NUK3
    • Q9NV27
    • Q9NVA9
    • Q9Y2X2

    Protein attributes for KLHL5 Gene

    Size:
    755 amino acids
    Molecular mass:
    84457 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD32565.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL08584.1; Type=Erroneous termination; Positions=735; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=BAA91845.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91933.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92121.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL5 Gene

neXtProt entry for KLHL5 Gene

Proteomics data for KLHL5 Gene at MOPED

Post-translational modifications for KLHL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLHL5 Gene

Domains & Families for KLHL5 Gene

Gene Families for KLHL5 Gene

Protein Domains for KLHL5 Gene

Suggested Antigen Peptide Sequences for KLHL5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PQ7

UniProtKB/Swiss-Prot:

KLHL5_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL5: view

Function for KLHL5 Gene

Gene Ontology (GO) - Molecular Function for KLHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL5: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL5 Gene

Localization for KLHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL5 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL5 Gene COMPARTMENTS Subcellular localization image for KLHL5 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 3
extracellular 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KLHL5 Gene

Pathways & Interactions for KLHL5 Gene

SuperPathways for KLHL5 Gene

No Data Available

Interacting Proteins for KLHL5 Gene

Gene Ontology (GO) - Biological Process for KLHL5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KLHL5 Gene

Drugs & Compounds for KLHL5 Gene

No Compound Related Data Available

Transcripts for KLHL5 Gene

Unigene Clusters for KLHL5 Gene

Kelch-like family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - - -
SP3:
SP4:
SP5: - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for KLHL5 Gene

GeneLoc Exon Structure for
KLHL5
ECgene alternative splicing isoforms for
KLHL5

Expression for KLHL5 Gene

mRNA expression in normal human tissues for KLHL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL5 Gene

This gene is overexpressed in Heart (51.6) and Prostate (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL5 Gene



SOURCE GeneReport for Unigene cluster for KLHL5 Gene Hs.272251

mRNA Expression by UniProt/SwissProt for KLHL5 Gene

Q96PQ7-KLHL5_HUMAN
Tissue specificity: Expressed in adrenal gland, ovary and thyroid gland and less abundantly in lymph node, prostate, spinal chord, testis and trachea.
genes like me logo Genes that share expression patterns with KLHL5: view

Protein tissue co-expression partners for KLHL5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KLHL5 Gene

Orthologs for KLHL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL5 35
  • 94.31 (n)
  • 98.87 (a)
KLHL5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL5 35
  • 95.31 (n)
  • 99.46 (a)
KLHL5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl5 35
  • 87.57 (n)
  • 97.32 (a)
Klhl5 16
Klhl5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL5 35
  • 99.51 (n)
  • 99.34 (a)
KLHL5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl5 35
  • 89.22 (n)
  • 97.74 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHL5 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL5 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL5 35
  • 82.69 (n)
  • 90.86 (a)
KLHL5 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL5 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl5 35
  • 77.98 (n)
  • 86.85 (a)
zebrafish
(Danio rerio)
Actinopterygii klhl5 35
  • 69.55 (n)
  • 80.96 (a)
klhl5 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15097 37
  • 41 (a)
CG17754 37
  • 60 (a)
CG3571 37
  • 40 (a)
CG17754 35
  • 54.82 (n)
  • 58.57 (a)
CG17754 36
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001513 35
  • 57.4 (n)
  • 60.07 (a)
worm
(Caenorhabditis elegans)
Secernentea T27E9.4a 37
  • 33 (a)
T27E9.4b 37
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6119 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for KLHL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHL5 Gene

ENSEMBL:
Gene Tree for KLHL5 (if available)
TreeFam:
Gene Tree for KLHL5 (if available)

Paralogs for KLHL5 Gene

Pseudogenes.org Pseudogenes for KLHL5 Gene

genes like me logo Genes that share paralogs with KLHL5: view

Variants for KLHL5 Gene

Sequence variations from dbSNP and Humsavar for KLHL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_033985 -
rs2711941 - 39,062,542(-) AAAAA(A/G/T)ATGTA intron-variant, reference, missense
rs440693 -- 39,142,281(+) tccta(G/T)ctact intron-variant
rs958708 -- 39,057,256(+) AGGGA(C/T)ATAGT intron-variant
rs1137714 -- 39,143,105(+) GACCA(G/T)TGTCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KLHL5 Gene

Variant ID Type Subtype PubMed ID
esv28537 CNV Loss 19812545
nsv878940 CNV Gain 21882294
esv2727455 CNV Deletion 23290073
esv272117 CNV Insertion 20981092
esv274607 CNV Insertion 20981092
nsv822540 CNV Gain 20364138
esv28236 CNV Gain 19812545

Variation tolerance for KLHL5 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL5 Gene

HapMap Linkage Disequilibrium report
KLHL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL5 Gene

Disorders for KLHL5 Gene

Relevant External Links for KLHL5

Genetic Association Database (GAD)
KLHL5
Human Genome Epidemiology (HuGE) Navigator
KLHL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL5

No disorders were found for KLHL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL5 Gene

Publications for KLHL5 Gene

  1. Characterization of a novel splicing variant of KLHL5, a member of the kelch protein family. (PMID: 14672410) Xu J. … Mao Y. (Mol. Biol. Rep. 2003) 2 3 4 23 67
  2. Cloning and characterization of KLHL5, a novel human gene encoding a kelch-related protein with a BTB domain. (PMID: 11590829) Wang S. … Mao Y. (Biochem. Genet. 2001) 2 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations. (PMID: 23829686) Ding L. … Mersha T.B. (Hum. Genomics 2013) 3

Products for KLHL5 Gene

Sources for KLHL5 Gene

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