Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL5 Gene

Aliases for KLHL5 Gene

  • Kelch-Like Family Member 5 2 3
  • Kelch (Drosophila)-Like 5 2
  • Kelch-Like 5 (Drosophila) 2

External Ids for KLHL5 Gene

Previous GeneCards Identifiers for KLHL5 Gene

  • GC04M038768
  • GC04M039139
  • GC04P038898
  • GC04P038886
  • GC04P038723
  • GC04P038371

Summaries for KLHL5 Gene

GeneCards Summary for KLHL5 Gene

KLHL5 (Kelch-Like Family Member 5) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL5 Gene

Genomics for KLHL5 Gene

Regulatory Elements for KLHL5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL5 Gene

39,044,688 bp from pter
39,126,857 bp from pter
82,170 bases
Plus strand

Genomic View for KLHL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL5 Gene

Proteins for KLHL5 Gene

  • Protein details for KLHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 5
    Protein Accession:
    Secondary Accessions:
    • A8K170
    • B7WP68
    • E9PCF4
    • F8WAE7
    • G3XA92
    • Q6Y881
    • Q86XW0
    • Q9NUK3
    • Q9NV27
    • Q9NVA9
    • Q9Y2X2

    Protein attributes for KLHL5 Gene

    755 amino acids
    Molecular mass:
    84457 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD32565.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL08584.1; Type=Erroneous termination; Positions=735; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=BAA91845.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91933.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92121.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL5 Gene

neXtProt entry for KLHL5 Gene

Proteomics data for KLHL5 Gene at MOPED

Post-translational modifications for KLHL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLHL5 Gene

Domains for KLHL5 Gene

Gene Families for KLHL5 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96PQ7
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL5: view

Function for KLHL5 Gene

Gene Ontology (GO) - Molecular Function for KLHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL5: view

Animal Model Products

miRNA for KLHL5 Gene

miRTarBase miRNAs that target KLHL5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL5 Gene

Localization for KLHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL5 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for KLHL5 Gene COMPARTMENTS Subcellular localization image for KLHL5 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 3
extracellular 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 14672410
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KLHL5: view

Pathways for KLHL5 Gene

SuperPathways for KLHL5 Gene

No Data Available

Interacting Proteins for KLHL5 Gene

Gene Ontology (GO) - Biological Process for KLHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KLHL5: view

No data available for Pathways by source for KLHL5 Gene

Transcripts for KLHL5 Gene

Unigene Clusters for KLHL5 Gene

Kelch-like family member 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for KLHL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL5 Gene

mRNA expression in normal human tissues for KLHL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KLHL5 Gene

This gene is overexpressed in Heart (51.6) and Prostate (12.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL5 Gene

SOURCE GeneReport for Unigene cluster for KLHL5 Gene Hs.272251

mRNA Expression by UniProt/SwissProt for KLHL5 Gene

Tissue specificity: Expressed in adrenal gland, ovary and thyroid gland and less abundantly in lymph node, prostate, spinal chord, testis and trachea
genes like me logo Genes that share expressions with KLHL5: view

Expression partners for KLHL5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KLHL5 Gene

Orthologs for KLHL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL5 35
  • 94.31 (n)
  • 98.87 (a)
KLHL5 36
  • 98 (a)
(Canis familiaris)
Mammalia KLHL5 35
  • 95.31 (n)
  • 99.46 (a)
KLHL5 36
  • 97 (a)
(Mus musculus)
Mammalia Klhl5 35
  • 87.57 (n)
  • 97.32 (a)
Klhl5 16
Klhl5 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHL5 35
  • 99.51 (n)
  • 99.34 (a)
KLHL5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Klhl5 35
  • 89.22 (n)
  • 97.74 (a)
(Monodelphis domestica)
Mammalia KLHL5 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL5 36
  • 96 (a)
(Gallus gallus)
Aves KLHL5 35
  • 82.69 (n)
  • 90.86 (a)
KLHL5 36
  • 89 (a)
(Anolis carolinensis)
Reptilia KLHL5 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl5 35
  • 77.98 (n)
  • 86.85 (a)
(Danio rerio)
Actinopterygii klhl5 35
  • 69.55 (n)
  • 80.96 (a)
klhl5 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15097 37
  • 41 (a)
CG17754 37
  • 60 (a)
CG3571 37
  • 40 (a)
CG17754 35
  • 54.82 (n)
  • 58.57 (a)
CG17754 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001513 35
  • 57.4 (n)
  • 60.07 (a)
(Caenorhabditis elegans)
Secernentea T27E9.4a 37
  • 33 (a)
T27E9.4b 37
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6119 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
Species with no ortholog for KLHL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHL5 Gene

Gene Tree for KLHL5 (if available)
Gene Tree for KLHL5 (if available)

Paralogs for KLHL5 Gene Pseudogenes for KLHL5 Gene

genes like me logo Genes that share paralogs with KLHL5: view

Variants for KLHL5 Gene

Sequence variations from dbSNP and Humsavar for KLHL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs13182 -- 39,121,293(+) TGTGA(A/T)CACAC utr-variant-3-prime
rs891434 -- 39,069,010(+) GCGGA(C/T)AGGTA intron-variant
rs958708 -- 39,057,256(+) AGGGA(C/T)ATAGT intron-variant
rs964607 -- 39,084,776(+) CAATT(A/G)TACTT intron-variant
rs964608 -- 39,084,960(+) TTTTA(C/T)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL5 Gene

Variant ID Type Subtype PubMed ID
esv28537 CNV Loss 19812545
nsv878940 CNV Gain 21882294
esv2727455 CNV Deletion 23290073
esv272117 CNV Insertion 20981092
esv274607 CNV Insertion 20981092
nsv822540 CNV Gain 20364138
esv28236 CNV Gain 19812545

Relevant External Links for KLHL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL5 Gene

Disorders for KLHL5 Gene

Relevant External Links for KLHL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KLHL5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLHL5 Gene

Publications for KLHL5 Gene

  1. Characterization of a novel splicing variant of KLHL5, a member of the kelch protein family. (PMID: 14672410) Xu J. … Mao Y. (Mol. Biol. Rep. 2003) 2 3 4 23
  2. Cloning and characterization of KLHL5, a novel human gene encoding a kelch-related protein with a BTB domain. (PMID: 11590829) Wang S. … Mao Y. (Biochem. Genet. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for KLHL5 Gene

Sources for KLHL5 Gene

Back to Top