Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KLHL42 Gene

protein-coding   GIFtS: 42
GCID: GC12P027932

Kelch-Like Family Member 42

(Previous name: kelch domain containing 5)
(Previous symbol: KLHDC5)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kelch-Like Family Member 421 2     Ctb92 3
KLHDC51 2 3     Kelch-Like Family, Member 422
Kelch Domain Containing 51 2     Kelch-Like Protein 422
Cullin-3-Binding Protein 92 3     KIAA13403
Kelch Domain-Containing Protein 52 3     

External Ids:    HGNC: 292521   Entrez Gene: 575422   Ensembl: ENSG000000874487   UniProtKB: Q9P2K63   

Export aliases for KLHL42 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KLHL42 Gene:
KLHL42 (kelch-like family member 42) is a protein-coding gene. Diseases associated with KLHL42 include ataxia. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is KLHL13.

UniProtKB/Swiss-Prot: KLH42_HUMAN, Q9P2K6
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and
subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KLHL42
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL42 promoter sequence
   Search Chromatin IP Primers for KLHL42

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.22   Ensembl cytogenetic band:  12p11.22   HGNC cytogenetic band: 12p11.22

KLHL42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL42 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P027932:  view genomic region     (about GC identifiers)

Start:
27,932,953 bp from pter      End:
27,955,973 bp from pter
Size:
23,021 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KLH42_HUMAN, Q9P2K6 (See protein sequence)
Recommended Name: Kelch-like protein 42  
Size: 505 amino acids; 56868 Da
Subunit: Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts
(via the BTB domain) with CUL3. Interacts (via the kelch domains) with KATNA1
Sequence caution: Sequence=AAH28742.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q2VPK1 Q8N334

Explore the universe of human proteins at neXtProt for KLHL42: NX_Q9P2K6

Explore proteomics data for KLHL42 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys502
  • Modification sites at PhosphoSitePlus

  • See KLHL42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065833.1  
    ENSEMBL proteins: 
     ENSP00000370671   ENSP00000444748   ENSP00000443934  

    KLHL42 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KLHL42
    OriGene Protein Over-expression Lysate for KLHL42
    OriGene MassSpec for KLHL42
    OriGene Custom Protein Services for KLHL42
    GenScript Custom Purified and Recombinant Proteins Services for KLHL42
    Novus Biologicals KLHL42 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    KLHL42 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLHL42
    Novus Biologicals KLHL42 Antibodies
    Search for Antibodies for KLHL42 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for KLHL42
    LSBio Antibodies in human, mouse, rat for KLHL42

    KLHL42 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLHL42
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHL42
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KLHL: Kelch-like

    5 InterPro protein domains:
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR011705 BACK
     IPR000210 BTB/POZ-like
     IPR015915 Kelch-typ_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q9P2K6

    ProtoNet protein and cluster: Q9P2K6

    UniProtKB/Swiss-Prot: KLH42_HUMAN, Q9P2K6
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH42_HUMAN, Q9P2K6
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
    mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and
    subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis
    Induction: Up-regulated during mitosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19261606
    GO:0005515protein binding IPI19261606
         
    KLHL42 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL42
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHL42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL42
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL42

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHL42:
    hsa-mir-21-5p (MIRT030926), hsa-mir-340-5p (MIRT019582), hsa-mir-615-3p (MIRT016145), hsa-mir-192-5p (MIRT026594), hsa-mir-181a-5p (MIRT025204), hsa-mir-30c-5p (MIRT047964), hsa-mir-1 (MIRT003852), hsa-mir-32-5p (MIRT028299)

    Block miRNA regulation of human, mouse, rat KLHL42 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLHL42
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLHL42
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL42

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHL42

    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL42 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for KLHL42
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL42

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHL42
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL42 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL42


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KLH42_HUMAN, Q9P2K6: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized
    diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more
    widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated
    chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter
    cells. Not detected at the midbody region during cytokinesis

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005819spindle IEA--
    GO:0031463Cul3-RING ubiquitin ligase complex IDA19261606

    KLHL42 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: KLH42_HUMAN, Q9P2K6
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL42
    Interactions:

        Search GeneGlobe Interaction Network for KLHL42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for KLHL42 (Q9P2K62, 3 ENSP000003706714) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384322, 3, ENSP000002403164MINT-2875196 I2D: score=3 STRING: ENSP00000240316
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2875177 I2D: score=3 STRING: ENSP00000357292
    SERTAD1Q9UHV23, ENSP000003506334I2D: score=4 STRING: ENSP00000350633
    UBQLN1Q9UMX03, ENSP000003655764I2D: score=4 STRING: ENSP00000365576
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19261606
    GO:0007067mitosis IEA--
    GO:0032886regulation of microtubule-based process IMP19261606
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IDA19261606

    KLHL42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL42 (KLH42)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KLHL42 gene: 
    NM_020782.1  

    Unigene Cluster for KLHL42:

    Kelch-like family member 42
    Hs.505104  [show with all ESTs]
    Unigene Representative Sequence: NM_020782
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381271(uc001rij.3) ENST00000539176 ENST00000543254 ENST00000540301

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHL42 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLHL42
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLHL42
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL42
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL42 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for KLHL42
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL42
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL42
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KLHL42
      QuantiTect SYBR Green Assays in human, mouse, rat KLHL42
      QuantiFast Probe-based Assays in human, mouse, rat KLHL42

    Additional mRNA sequence: 

    AB037761.1 AK002197.1 AK095405.1 BC020387.1 BC028742.1 BC108669.1 BC137116.1 BC137117.1 

    9 DOTS entries:

    DT.206900  DT.100721500  DT.97824256  DT.446969  DT.75181671  DT.100717110  DT.91657210  DT.92042808 
    DT.100709764 

    Selected AceView cDNA sequences (see all 249):

    AK095405 CB162758 BQ631585 BQ631441 AA721680 CA848864 CR593861 BU147104 
    AI962670 AI744061 BF475665 CA848985 CR621766 BM450209 AA907822 Z44615 
    AA234734 BE466436 BQ061092 AA766909 AA687307 BU683083 AW075762 CR602758 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KLHL42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLHL42 Expression
    About this image


    KLHL42 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
    KLHL42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL42 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505104
        Custom PCR Arrays for KLHL42
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL42
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KLHL42
    QuantiTect SYBR Green Assays in human, mouse, rat KLHL42
    QuantiFast Probe-based Assays in human, mouse, rat KLHL42
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KLHL42 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl421 , 5 kelch domain containing 55
    kelch-like 421
    87.15(n)1
    93.51(a)1
      6 (77.70 cM)5
    2325391  NM_001081237.11  NP_001074706.11 
     1470913795 
    chicken
    (Gallus gallus)
    Aves KLHDC51 kelch domain containing 5 73.47(n)
    76(a)
      419046  XM_417237.4  XP_417237.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL426
    kelch-like family member 42
    62(a)
    1 ↔ 1
    5(82891861-82902969)
    zebrafish
    (Danio rerio)
    Actinopterygii klhl421 kelch-like family, member 42 67.39(n)
    65.09(a)
      567545  NM_001045136.2  NP_001038601.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18126
    --
    17(a)
    1 → many
    X(20382574-20386859)


    ENSEMBL Gene Tree for KLHL42 (if available)
    TreeFam Gene Tree for KLHL42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KLHL42 gene
    KLHL132  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  KLHL322  
    KLHL92  KLHL142  KLHL152  KLHDC7B2  KLHL362  KLHL332  KLHDC7A2  
    2 SIMAP similar genes for KLHL42 using alignment to 3 protein entries:     KLH42_HUMAN (see all proteins):
    KLHDC5    KLHL1

    KLHL42 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KLHL42 (see all 518)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471004631,2
    C--27931254(+) CAACAA/CCACCT 1 -- us2k10--------
    rs1384800091,2
    --27931258(+) AACACA/CTCTCT 1 -- us2k10--------
    rs1416619571,2
    --27931426(+) AATAGC/GGGAAA 1 -- us2k10--------
    rs714520671,2
    C,F--27931498(+) AATAAT/AAAAAA 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs110491431,2
    --27931510(+) AAAAAC/ACAAAC 1 -- us2k1 tfbs31Minor allele frequency- A:0.50NA 2
    rs788872161,2
    C--27931510(+) AAAAA-/CCAAACA 1 -- us2k10--------
    rs110491441,2
    --27931511(+) AAAACC/AAAACA 1 -- us2k1 tfbs31Minor allele frequency- A:0.50NA 2
    rs1818260301,2
    --27931552(+) CATAGA/GTGGTT 1 -- us2k10--------
    rs1156078571,2
    F--27931653(+) TTCTCC/TCTTCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1173440001,2
    F--27931697(+) CCCCCC/TACCCC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for KLHL42 (27932953 - 27955973 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLHL42: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL42
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for KLHL42:    
    About MalaCards
    ataxia


    KLHL42 for disorders           About GeneDecksing


    Export disorders for KLHL42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KLHL42 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with KLHL42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. (PubMed id 19261606)1, 2, 3 Cummings C.M.... Singer J.D. (J. Biol. Chem. 2009)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57542 HGNC: 29252 AceView: KIAA1340 Ensembl:ENSG00000087448 euGenes: HUgn57542
    ECgene: KLHL42 H-InvDB: KLHL42

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1340

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KLHL42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLHL42 gene:
    Search GeneIP for patents involving KLHL42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLHL42  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KLHL42  
     OriGene MassSpec something-or-other for KLHL42   OriGene clones in human, mouse for KLHL42  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLHL42   OriGene Purified Protein for KLHL42  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHL42   OriGene Custom Protein Services for KLHL42  

     
     
     Block miRNA regulation of human, mouse, rat KLHL42 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLHL42
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL42 Predesigned siRNA for gene silencing in human, mouse, rat KLHL42
     QuantiFast Probe-based Assays in human, mouse, rat KLHL42 QuantiTect SYBR Green Assays in human, mouse, rat KLHL42
     Custom PCR Arrays for KLHL42 Search Chromatin IP Primers for KLHL42
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KLHL42 Search GeneGlobe Interaction Network for KLHL42
     Search Regulatory tfbs for KLHL42
     GenScript Custom Purified and Recombinant Proteins Services for KLHL42 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for KLHL42
     GenScript Custom Assay Services for KLHL42 GenScript Custom overexpressing Cell Line Services for KLHL42
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KLHL42 (KLH42)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KLHL42 antibodies
     KLHL42 lysates
     Search for Antibodies for KLHL42 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KLHL42
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL42
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL42
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KLHL42
     SwitchGear Promoter luciferase reporter plasmids for KLHL42
     ThermoFisher Antibodies for KLHL42
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL42
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL42
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHL42
     LSBio Antibodies in human, mouse, rat for KLHL42
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHL42 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4