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Aliases for KLHL42 Gene

Aliases for KLHL42 Gene

  • Kelch-Like Family Member 42 2 3
  • Kelch Domain-Containing Protein 5 3 4
  • Cullin-3-Binding Protein 9 3 4
  • Kelch Domain Containing 5 2 3
  • KLHDC5 3 4
  • Ctb9 3 4
  • Kelch-Like Family, Member 42 3
  • KIAA1340 4

External Ids for KLHL42 Gene

Previous HGNC Symbols for KLHL42 Gene

  • KLHDC5

Previous GeneCards Identifiers for KLHL42 Gene

  • GC12P027932

Summaries for KLHL42 Gene

GeneCards Summary for KLHL42 Gene

KLHL42 (Kelch-Like Family Member 42) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL42 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL42 Gene

Genomics for KLHL42 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL42 Gene

Chromosome:
12
Start:
27,779,958 bp from pter
End:
27,803,040 bp from pter
Size:
23,083 bases
Orientation:
Plus strand

Genomic View for KLHL42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL42 Gene

No data available for Regulatory Elements for KLHL42 Gene

Proteins for KLHL42 Gene

  • Protein details for KLHL42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K6-KLH42_HUMAN
    Recommended name:
    Kelch-like protein 42
    Protein Accession:
    Q9P2K6
    Secondary Accessions:
    • Q2VPK1
    • Q8N334

    Protein attributes for KLHL42 Gene

    Size:
    505 amino acids
    Molecular mass:
    56868 Da
    Quaternary structure:
    • Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts (via the BTB domain) with CUL3. Interacts (via the kelch domains) with KATNA1.
    SequenceCaution:
    • Sequence=AAH28742.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KLHL42 Gene

Proteomics data for KLHL42 Gene at MOPED

Post-translational modifications for KLHL42 Gene

  • Ubiquitination at Lys 502
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL42 Gene

Domains & Families for KLHL42 Gene

Gene Families for KLHL42 Gene

Protein Domains for KLHL42 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2K6

UniProtKB/Swiss-Prot:

KLH42_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL42: view

Function for KLHL42 Gene

Molecular function for KLHL42 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated during mitosis.

Gene Ontology (GO) - Molecular Function for KLHL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19261606
GO:0005515 protein binding IPI 19261606
genes like me logo Genes that share ontologies with KLHL42: view

Phenotypes for KLHL42 Gene

GenomeRNAi human phenotypes for KLHL42:
genes like me logo Genes that share phenotypes with KLHL42: view

Animal Model Products

miRNA for KLHL42 Gene

miRTarBase miRNAs that target KLHL42

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL42

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL42 Gene

Localization for KLHL42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL42 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.

Gene Ontology (GO) - Cellular Components for KLHL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 19261606
genes like me logo Genes that share ontologies with KLHL42: view

No data available for Subcellular locations from COMPARTMENTS for KLHL42 Gene

Pathways & Interactions for KLHL42 Gene

SuperPathways for KLHL42 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P2K6-KLH42_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KLHL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19261606
GO:0007067 mitotic nuclear division IEA --
GO:0032886 regulation of microtubule-based process IMP 19261606
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 19261606
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with KLHL42: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL42 Gene

Drugs & Compounds for KLHL42 Gene

No Compound Related Data Available

Transcripts for KLHL42 Gene

Unigene Clusters for KLHL42 Gene

Kelch-like family member 42:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL42

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL42 Gene

No ASD Table

Relevant External Links for KLHL42 Gene

GeneLoc Exon Structure for
KLHL42
ECgene alternative splicing isoforms for
KLHL42

Expression for KLHL42 Gene

mRNA expression in normal human tissues for KLHL42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL42 Gene

This gene is overexpressed in Urinary Bladder (13.8), Colon (8.0), Seminal vesicle (7.2), Testis (6.7), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL42 Gene



SOURCE GeneReport for Unigene cluster for KLHL42 Gene Hs.505104

genes like me logo Genes that share expression patterns with KLHL42: view

Protein tissue co-expression partners for KLHL42 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL42 Gene

Orthologs for KLHL42 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHDC5 35
  • 91.55 (n)
  • 95.05 (a)
KLHL42 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL42 35
  • 93.6 (n)
  • 96.83 (a)
KLHL42 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl42 35
  • 87.15 (n)
  • 93.51 (a)
Klhl42 16
Klhl42 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHDC5 35
  • 99.8 (n)
  • 100 (a)
KLHDC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl42 35
  • 86.41 (n)
  • 92.9 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHL42 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHDC5 35
  • 73.47 (n)
  • 76 (a)
KLHL42 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL42 36
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii klhl42 35
  • 67.39 (n)
  • 65.09 (a)
klhl42 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1812 36
  • 17 (a)
OneToMany
Species with no ortholog for KLHL42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL42 Gene

ENSEMBL:
Gene Tree for KLHL42 (if available)
TreeFam:
Gene Tree for KLHL42 (if available)

Paralogs for KLHL42 Gene

(2) SIMAP similar genes for KLHL42 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLHL42: view

Variants for KLHL42 Gene

Sequence variations from dbSNP and Humsavar for KLHL42 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9029 -- 27,802,908(+) CAAGT(C/G)TAGCT utr-variant-3-prime
rs1050287 -- 27,801,574(+) GAATA(C/T)ATAAC utr-variant-3-prime
rs1050288 -- 27,802,363(+) TAAAA(C/T)ATTCC utr-variant-3-prime
rs1129784 -- 27,800,348(+) GTGTG(G/T)GTGTG utr-variant-3-prime
rs1129785 -- 27,800,349(+) gtgtg(G/T)gtgtg utr-variant-3-prime

Variation tolerance for KLHL42 Gene

Residual Variation Intolerance Score: 17.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL42 Gene

HapMap Linkage Disequilibrium report
KLHL42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLHL42 Gene

Disorders for KLHL42 Gene

Relevant External Links for KLHL42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL42
genes like me logo Genes that share disorders with KLHL42: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL42 Gene

Publications for KLHL42 Gene

  1. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. (PMID: 19261606) Cummings C.M. … Singer J.D. (J. Biol. Chem. 2009) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Novel Cul3 binding proteins function to remodel E3 ligase complexes. (PMID: 25011449) Wimuttisuk W. … Singer J.D. (BMC Cell Biol. 2014) 67
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 67

Products for KLHL42 Gene

Sources for KLHL42 Gene

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