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KLHL41 Gene

protein-coding   GIFtS: 42
GCID: GC02P170367

Kelch-Like Family Member 41

(Previous names: kelch repeat and BTB (POZ) domain containing 10, kelch-like...)
(Previous symbol: KBTBD10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 411 2     Kelch-Like 41 (Drosophila)1
KBTBD101 2 3 5     Krp12
Kelch Repeat And BTB (POZ) Domain Containing 101 2     Kelch-Like 412
Sarcomeric Muscle Protein1 2     Kelch-Like Protein 412
Kel-Like Protein 232 3     KRP13
Kelch Repeat And BTB Domain-Containing Protein 102 3     Sarcosin3
Kelch-Related Protein 12 3     NEM95
SARCOSIN2 5     

External Ids:    HGNC: 169051   Entrez Gene: 103242   Ensembl: ENSG000002394747   OMIM: 6077015   UniProtKB: O606623   

Export aliases for KLHL41 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL41 Gene:
KLHL41 (kelch-like family member 41) is a protein-coding gene. Diseases associated with KLHL41 include severe congenital nemaline myopathy, and intermediate nemaline myopathy. An important paralog of this gene is KLHL21.

UniProtKB/Swiss-Prot: KLH41_HUMAN, O60662
Function: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation
of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into
mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity)

Gene Wiki entry for KLHL41 (KBTBD10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KLHL41
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL41 promoter sequence
   Search Chromatin IP Primers for KLHL41

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

KLHL41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL41 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P170367:  view genomic region     (about GC identifiers)

Start:
170,366,212 bp from pter      End:
170,382,772 bp from pter
Size:
16,561 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLH41_HUMAN, O60662 (See protein sequence)
Recommended Name: Kelch-like protein 41  
Size: 606 amino acids; 68037 Da
Subunit: Interacts with NRAP. Interacts with LASP1 (By similarity). Part of a complex that contains CUL3, RBX1 and
KLHL41
Secondary accessions: Q53R42
Alternative splicing: 2 isoforms:  O60662-1   O60662-2   

Explore the universe of human proteins at neXtProt for KLHL41: NX_O60662

Explore proteomics data for KLHL41 at MOPED

Post-translational modifications: 

  • Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for
    proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination1
  • Ubiquitination2 at Lys583
  • Modification sites at PhosphoSitePlus

  • See KLHL41 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006054.2  
    ENSEMBL proteins: 
     ENSP00000284669  

    KLHL41 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR013069 BTB_POZ
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry O60662

    ProtoNet protein and cluster: O60662

    4 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB001497 Methylated-DNA-[protein]-cysteine S-methyltransferase
    IPB006651 Kelch repeat signature
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH41_HUMAN, O60662
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 Kelch repeats


    KLHL41 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH41_HUMAN, O60662
    Function: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation
    of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into
    mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    KLHL41 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL41
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLH41_HUMAN, O60662: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, pseudopodium. Cell projection, ruffle.
    Cytoplasm, myofibril, sarcomere, M line (By similarity). Note=Predominantly cytoplasmic but can colocalize with
    F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005634nucleus ----
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IDA19424503
    GO:0005813centrosome ----

    KLHL41 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL41
    Interactions:

        Search GeneGlobe Interaction Network for KLHL41

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for KLHL41 (O606621, 3 ENSP000002846694) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NRAPQ86VF73, ENSP000003530784I2D: score=1 STRING: ENSP00000353078
    SLC2A4P146723I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006941striated muscle contraction TAS9655184
    GO:0016567protein ubiquitination IDA15983046
    GO:0030239myofibril assembly ISS--
    GO:0031275regulation of lateral pseudopodium assembly IEA--
    GO:0035914skeletal muscle cell differentiation ISS--

    KLHL41 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL41 (KLH41)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLHL41 gene: 
    NM_006063.2  

    Unigene Cluster for KLHL41:

    Kelch-like family member 41
    Hs.50550  [show with all ESTs]
    Unigene Representative Sequence: NM_006063
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284669(uc002ueu.1) ENST00000480330 ENST00000463400
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat KLHL41

    Additional mRNA sequence: 

    AF056929.1 AF333387.1 AK316571.1 AY364252.1 BC006534.2 

    6 DOTS entries:

    DT.318408  DT.100781183  DT.120973591  DT.100781185  DT.95358215  DT.95370555 

    Selected AceView cDNA sequences (see all 236):

    F29300 BX500013 BU581368 W21178 AI695762 AI367745 AA086385 AA112962 
    F34223 AA418529 BQ960982 F29103 BM699567 AI668950 BM142673 AA653726 
    AI418760 AA393742 CB857422 NM_006063 AU121012 AA706028 AA418414 CD676990 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLHL41 Expression
    About this image


    KLHL41 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Heart (Cardiovascular System)
     
     Thyroid (Endocrine System)
    KLHL41 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL41 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50550

    UniProtKB/Swiss-Prot: KLH41_HUMAN, O60662
    Tissue specificity: Sarcomeric muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL41 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl411 , 5 kelch repeat and BTB (POZ) domain containing 105
    kelch-like 411
    88.67(n)1
    95.38(a)1
      2 (40.92 cM)5
    2280031  NM_001081087.11  NP_001074556.11 
     696701205 
    chicken
    (Gallus gallus)
    Aves KBTBD101 kelch repeat and BTB (POZ) domain containing 10 79.26(n)
    85.48(a)
      424164  XM_422010.4  XP_422010.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984492 hypothetical protein LOC398449 75.16(n)    BC043951.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb522 sbcb52 70.56(n)   321064  BC054912.1 


    ENSEMBL Gene Tree for KLHL41 (if available)
    TreeFam Gene Tree for KLHL41 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL41 gene
    KLHL212  KLHL62  KBTBD82  KBTBD122  KBTBD22  KLHL242  ENC12  KLHL382  
    KLHL292  KBTBD32  KLHL232  KLHL402  KBTBD72  KLHL302  KBTBD62  KLHL252  
    KLHL352  
    3 SIMAP similar genes for KLHL41 using alignment to 1 protein entry:     KLH41_HUMAN:
    SARCOSIN    BBS5    KLHL40

    KLHL41 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL41 (see all 395)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37549221,2
    C,F,H--170364235(+) TGTTTT/GTTTCA 1 -- us2k17Minor allele frequency- G:0.05NS EA NA 660
    rs1931744661,2
    --170364270(+) GACTAA/GTAAGG 1 -- us2k10--------
    rs1852692351,2
    --170364385(+) AAGCAA/GCTGTT 1 -- us2k10--------
    rs1901679691,2
    --170364416(+) AACCTG/TTAGTG 1 -- us2k10--------
    rs1927853831,2
    --170364426(+) GGCATC/TTATAA 1 -- us2k10--------
    rs800906381,2
    C,F--170364512(+) GTAAAA/GTAAAA 1 -- us2k11Minor allele frequency- G:0.14WA 118
    rs1161102161,2
    F--170364525(+) AAAGGC/ACTTTA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1839757891,2
    --170364531(+) CTTTAC/TTCATG 1 -- us2k10--------
    rs739716231,2
    C,F--170364600(+) CAACAA/GATACT 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1144036211,2
    C,F--170364616(+) AGCACT/CCACGA 1 -- us2k12Minor allele frequency- C:0.05NA EA 240

    HapMap Linkage Disequilibrium report for KLHL41 (170366212 - 170382772 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLHL41: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL41
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607701   
    OMIM disorders: 615731  
    6 diseases for KLHL41:    
    About MalaCards
    severe congenital nemaline myopathy    intermediate nemaline myopathy    typical nemaline myopathy    childhood-onset nemaline myopathy
    thymoma    hypertrophic cardiomyopathy


    KLHL41 for disorders           About GeneDecksing


    Export disorders for KLHL41 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL41 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with KLHL41)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and muscle-specific expression of human sarcosin transcripts. (PubMed id 9655184)1, 2, 3 Taylor A.... Carlson K.D. (Mol. Cell. Biochem. 1998)
    2. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PubMed id 19424503)1, 2 Wang X.J. and Zhang D.D. (PLoS ONE 2009)
    3. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. (PubMed id 15983046)1, 2 Zhang D.D.... Hannink M. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells. (PubMed id 10713668)1, 2 Spence H.J....Ozanne B.W. (Oncogene 2000)
    6. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    7. Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy. (PubMed id 24268659)1 Gupta V.A....Beggs A.H. (Am. J. Hum. Genet. 2013)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). (PubMed id 16396496)1 Foster L.J....Klip A. (J. Proteome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10324 HGNC: 16905 AceView: KBTBD10 Ensembl:ENSG00000239474 euGenes: HUgn10324
    ECgene: KLHL41 H-InvDB: KLHL41

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL41 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL41 gene:
    Search GeneIP for patents involving KLHL41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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