Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL4 Gene

protein-coding   GIFtS: 49
GCID: GC0XP086772

kelch-like family member 4

(Previous names: kelch (Drosophila)-like 4, kelch-like 4 (Drosophila) )
 Explore 3 diseases affiliated with
KLHL4 via our new
 Human Malady Compendium 
Biological research products
for KLHL4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Kelch-Like Family Member 41 2     Kelch (Drosophila)-Like 41
DKELCHL1 2     Kelch-Like 4 (Drosophila)1
KHL41 2     Kelch-Like Protein 42
KIAA16871 3     

External Ids:    HGNC: 63551   Entrez Gene: 560622   Ensembl: ENSG000001022717   OMIM: 3003485   UniProtKB: Q9C0H63   

Export aliases for KLHL4 gene to outside databases

Previous GC identifers: GC0XP082152 GC0XP083849 GC0XP084808 GC0XP085544 GC0XP086578 GC0XP080353


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLHL4:
This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a
POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific
function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants
encoding different isoforms. (provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL4 gene promoter:
         Nkx3-1   HOXA9   HOXA9B   Nkx3-1 v4   Nkx3-1 v1   AREB6   Nkx3-1 v2   Nkx3-1 v3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.3   Ensembl cytogenetic band:  Xq21.31   HGNC cytogenetic band: Xq21.3

KLHL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP086772:  view genomic region     (about GC identifiers)

Start:
86,772,715 bp from pter      End:
86,925,050 bp from pter
Size:
152,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLHL4_HUMAN, Q9C0H6 (See protein sequence)
Recommended Name: Kelch-like protein 4  
Size: 718 amino acids; 80245 Da
Subcellular location: Cytoplasm, cytoskeleton
Sequence caution: Sequence=BAB14199.1; Type=Erroneous initiation; Sequence=BAB21778.1; Type=Erroneous initiation;
Secondary accessions: B2RTW2 Q9Y3J5
Alternative splicing: 2 isoforms:  Q9C0H6-1   Q9C0H6-2   

Explore the universe of human proteins at neXtProt for KLHL4: NX_Q9C0H6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0H6

  • KLHL4 Protein expression data from MOPED and PaxDb:    About this image 
    KLHL4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_061990.2  NP_476503.1  

    ENSEMBL proteins: 
     ENSP00000362211   ENSP00000362206  

    Human Recombinant Protein Products for KLHL4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: KLHL4
    OriGene Custom Protein Services for KLHL4 
    GenScript Custom Purified and Recombinant Proteins Services for KLHL4
    Novus Biologicals KLHL4 Proteins
    Novus Biologicals KLHL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLHL4

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    KLHL4 for ontologies           About GeneDecksing



    KLHL4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLHL4 
    GenScript Custom Superior Antibodies Services for KLHL4
    Novus Biologicals KLHL4 Antibodies
    Search for Antibodies for KLHL4 at Abcam  
    Uscn Antibodies for KLHL4
    Search ThermoFisher Antibodies for KLHL4

    Assay Products for KLHL4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHL4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KLHL4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KLHL4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000210 BTB/POZ-like
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9C0H6

    ProtoNet protein and cluster: Q9C0H6

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLHL4_HUMAN, Q9C0H6
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003779actin binding IEA--
         
    KLHL4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KLHL4 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): KLHL4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL4
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL4 (see all 15):
    hsa-miR-3149 hsa-miR-16-2* hsa-miR-3136-5p hsa-miR-548k hsa-miR-27a hsa-miR-526b hsa-miR-128 hsa-miR-3681*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL4 (see all 7)
    OriGene shRNA RFP: KLHL4
    OriGene siRNA: KLHL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL4
    Sirion Biotech Custom design and validation of potent shRNA sequences against KLHL4 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHL4
    Sirion Biotech Customized adenovirus for overexpression of KLHL4 
    Sirion Biotech Customized adenovirus for potent knockdown of KLHL4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL4 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): KLHL4 (NM_019117)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHL4
    Search LifeMap BioReagents cell lines for KLHL4
    Sirion Biotech Customized stable knockdown cell line services for KLHL4 
    Sirion Biotech Customized inducible knockdown cell line services for KLHL4
    Sirion Biotech Customized stable overexpressing cell line services for KLHL4
    Sirion Biotech Customized inducible overexpressing cell line services for KLHL4

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KLHL4 (ENSP000003622064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR1ENSP000003641334STRING: ENSP00000364133
    ACVR1ENSP000002636404STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    KLHL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL4
    Search CenterWatch for drugs/clinical trials and news about KLHL4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL4 gene (2 alternative transcripts): 
    NM_019117.4  NM_057162.2  

    Unigene Cluster for KLHL4:

    Kelch-like 4 (Drosophila)
    Hs.49075  [show with all ESTs]
    Unigene Representative Sequence: NM_019117
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373119(uc004efa.2 uc004efb.2) ENST00000373114

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): KLHL4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL4
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL4 (see all 15):
    hsa-miR-3149 hsa-miR-16-2* hsa-miR-3136-5p hsa-miR-548k hsa-miR-27a hsa-miR-526b hsa-miR-128 hsa-miR-3681*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL4 (see all 7)
    OriGene shRNA RFP: KLHL4
    OriGene siRNA: KLHL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL4
    Sirion Biotech Custom design and validation of potent shRNA sequences against KLHL4 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL4 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): KLHL4 (NM_019117)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL4 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL4

    Additional cDNA sequence: 

    AB051474.1 AF284765.1 AF284766.1 AK022715.1 AK023057.1 AK056457.1 AL831868.1 AL832514.1 
    BC140839.1 BC140840.1 BC142652.1 BC146677.1 BC161675.1 

    2 DOTS entries:

    DT.40113204  DT.95137528 

    24/36 AceView cDNA sequences (see all 36):

    AI917374 BM718564 AU117238 AI679432 AU125721 NM_019117 AI675789 AI679942 
    AF284765 AL831868 AB051474 AA247484 AK023057 N64817 AK022715 AL832514 
    BX281120 AF284766 BU743007 AI743832 CB108922 AK056457 NM_057162 AU130089 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTTCTGTT
    KLHL4 Expression
    About this image

    KLHL4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumCardiac FibroblastsEpicardium
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See KLHL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL4

    SOURCE GeneReport for Unigene cluster: Hs.49075

    UniProtKB/Swiss-Prot: KLHL4_HUMAN, Q9C0H6
    Tissue specificity: Expressed in adult fibroblasts and in a range of fetal tissues including tongue, palate, and
    mandible

        SABiosciences Custom PCR Arrays for KLHL4
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLHL4 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KLHL41 kelch-like 4 (Drosophila) 77.44(n)
    83.29(a)
      422265  XM_420250.3  XP_420250.2 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL46
    --
    79(a)
    1 ↔ 1
    GL343409.1(146216-184977)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01080142.16
    zgc:1622986
    (see all 3)
    zgc:162298
    (see all 3)
    75(a)
    74(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    Zv9_NA577(5907-10498)
    14(27806002-27852531)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG177543   -- 57(a)
    (best of 4)
      8D10   --
    worm
    (Caenorhabditis elegans)
    Secernentea T27E9.4b3 ring canal protein like 32(a)
    (best of 3)
      III(13537863-13542591)   --


    ENSEMBL Gene Tree for KLHL4 (if available)
    TreeFam Gene Tree for KLHL4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL4 gene
    KLHL172  KLHL182  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  IPP2  
    KLHL32  KLHL82  KLHL102  KLHL12  KLHL22  
    18/21 SIMAP similar genes for KLHL4 using alignment to 2 protein entries:     KLHL4_HUMAN (see all proteins) (see all similar genes):
    DKFZp761P1717    KLHL5    KLHL1    KLHL20    KLHL17    KLHL12
    KLHL3    KLHL28    DKFZp686H07112    KLHL18    DKFZp686P15123    KLHL8
    KLHL2    KBTBD3    KLHL10    IPP    KEAP1    KLHL9

    KLHL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1940 NCBI SNPs in KLHL4 are shown (see all 1940    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850396981,2
    --86770753(+) TCAAAG/TAACAT 2 -- us2k10--------
    rs1882440271,2
    --86770848(+) TCCTAC/TCACAT 2 -- us2k10--------
    rs1473013771,2
    --86770947(+) CACACA/GCACAC 2 -- us2k10--------
    rs1916028671,2
    --86771416(+) AGGGAA/GAGGTA 2 -- us2k10--------
    rs1837841411,2
    --86771773(+) GCATTA/CTTGAT 2 -- us2k10--------
    rs1896876691,2
    --86771899(+) AAAACA/GTACTC 2 -- us2k10--------
    rs1813326811,2
    --86772187(+) ATGTTC/TCTAAA 2 -- us2k10--------
    rs1851735581,2
    --86772476(+) AACACC/TTCGCT 2 -- us2k10--------
    rs59692291,2
    C,F,A,H--86772478(+) CACTTC/TGCTTT 2 -- us2k116Minor allele frequency- T:0.34NS EA NA WA 1967
    rs1901043171,2
    --86772521(+) TGTACG/TTTGAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLHL4 (86772715 - 86925050 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLHL4: --
    Locus Specific Mutation Databases (LSDB): KLHL4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL4
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KLHL4 for disorders           About GeneDecksing

    OMIM gene information: 300348    OMIM disorders: --

    3 diseases for KLHL4:    About MalaCards
    mullerian aplasia    cleft palate with ankyloglossia    cleft palate

    1 disease from the University of Copenhagen DISEASES database for KLHL4:
    Cleft palate

    Export disorders for KLHL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL4 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with KLHL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of KLHL4, a novel human homologue of the Drosophila Kelch gene that maps within the X-linked cleft palate and ankyloglossia (CPX) critical region. (PubMed id 11401425)1, 2, 3 Braybrook C.... Stanier P. (2001)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    5. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    6. Genomic imbalances associated with mullerian aplasia. (PubMed id 18039948)1 Cheroki C....Rosenberg C. (2008)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56062 HGNC: 6355 AceView: KLHL4 Ensembl:ENSG00000102271 euGenes: HUgn56062
    ECgene: KLHL4 H-InvDB: KLHL4

    (According to HUGE)
    About This Section
    HUGE: KIAA1687

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL4 gene:
    Search GeneIP for patents involving KLHL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for KLHL4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL4  
     OriGene Protein Over-expression Lysate for KLHL4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KLHL4   OriGene 3'-UTR Clone for KLHL4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHL4   OriGene Custom Protein Services for KLHL4  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL4
     GenScript Custom Purified and Recombinant Proteins Services for KLHL4 GenScript cDNA clones with any tag delivered in your preferred vector for KLHL4
     GenScript Custom Assay Services for KLHL4 GenScript Custom Superior Antibodies Services for KLHL4
     GenScript Custom overexpressing Cell Line Services for KLHL4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLHL4 promoter
     Search Chromatin IP Primers for KLHL4
     RT2 qPCR Primer Assay in human, mouse, rat KLHL4
     Search GNC Networks for KLHL4
     SABiosciences Custom PCR Arrays for KLHL4
     Search Tocris compounds for KLHL4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLHL4 antibodies
     KLHL4 proteins
     KLHL4 lysates
     Search for Antibodies for KLHL4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KLHL4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KLHL4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KLHL4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KLHL4
     SwitchGear Promoter luciferase reporter plasmids for KLHL4
     Search ThermoFisher Antibodies for KLHL4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL4
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KLHL4
    Sirion Biotech Customized:
     stable knockdown cell line services for KLHL4
     inducible knockdown cell line services for KLHL4
     design and validation of potent shRNA sequences against KLHL4
     adenovirus for potent knockdown of KLHL4
     adenovirus for overexpression of KLHL4
     stable overexpressing cell line services for KLHL4
     inducible overexpressing cell line services for KLHL4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHL4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4