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KLHL4 Gene

protein-coding   GIFtS: 50
GCID: GC0XP086772

Kelch-Like Family Member 4

(Previous names: kelch (Drosophila)-like 4, kelch-like 4 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 41 2     KHL42
Kelch (Drosophila)-Like 41     Kelch-Like Protein 42
Kelch-Like 4 (Drosophila)1     KIAA16873
DKELCHL2     

External Ids:    HGNC: 63551   Entrez Gene: 560622   Ensembl: ENSG000001022717   OMIM: 3003485   UniProtKB: Q9C0H63   

Export aliases for KLHL4 gene to outside databases

Previous GC identifers: GC0XP082152 GC0XP083849 GC0XP084808 GC0XP085544 GC0XP086578 GC0XP080353


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLHL4 Gene:
This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a
POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific
function of this protein has not been determined. Alternative splicing of this gene results in two transcript
variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLHL4 Gene:
KLHL4 (kelch-like family member 4) is a protein-coding gene. Diseases associated with KLHL4 include mullerian aplasia, and cleft palate with ankyloglossia. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL17.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL4 gene promoter:
         Nkx3-1   HOXA9   HOXA9B   Nkx3-1 v4   Nkx3-1 v1   AREB6   Nkx3-1 v2   Nkx3-1 v3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL4 promoter sequence
   Search Chromatin IP Primers for KLHL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.3   Ensembl cytogenetic band:  Xq21.31   HGNC cytogenetic band: Xq21.3

KLHL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP086772:  view genomic region     (about GC identifiers)

Start:
86,772,715 bp from pter      End:
86,925,050 bp from pter
Size:
152,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLHL4_HUMAN, Q9C0H6 (See protein sequence)
Recommended Name: Kelch-like protein 4  
Size: 718 amino acids; 80245 Da
Sequence caution: Sequence=BAB14199.1; Type=Erroneous initiation; Sequence=BAB21778.1; Type=Erroneous initiation;
Secondary accessions: B2RTW2 Q9Y3J5
Alternative splicing: 2 isoforms:  Q9C0H6-1   Q9C0H6-2   

Explore the universe of human proteins at neXtProt for KLHL4: NX_Q9C0H6

Explore proteomics data for KLHL4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061990.2  NP_476503.1  

    ENSEMBL proteins: 
     ENSP00000362211   ENSP00000362206  

    KLHL4 Human Recombinant Protein Products:

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    Novus Biologicals KLHL4 Lysates
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    LSBio Antibodies in human, mouse, rat for KLHL4

    KLHL4 Assay Products:

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    Cloud-Clone Corp. CLIAs for KLHL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 6):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q9C0H6

    ProtoNet protein and cluster: Q9C0H6

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLHL4_HUMAN, Q9C0H6
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    KLHL4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL4
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    miRNA
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    miRTarBase miRNAs that target KLHL4:
    hsa-mir-335-5p (MIRT019091)

    Block miRNA regulation of human, mouse, rat KLHL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL4 (see all 15):
    hsa-miR-3149 hsa-miR-16-2* hsa-miR-3136-5p hsa-miR-548k hsa-miR-27a hsa-miR-526b hsa-miR-128 hsa-miR-3681*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat KLHL4

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLHL4_HUMAN, Q9C0H6: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    cytosol3
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ISS--
    GO:0005856cytoskeleton IEA--
    GO:0015630microtubule cytoskeleton ----

    KLHL4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL4
    Interactions:

        Search GeneGlobe Interaction Network for KLHL4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KLHL4 (ENSP000003622064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR1ENSP000003641334STRING: ENSP00000364133
    ACVR1ENSP000002636404STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    KLHL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLHL4 gene (2 alternative transcripts): 
    NM_019117.4  NM_057162.2  

    Unigene Cluster for KLHL4:

    Kelch-like family member 4
    Hs.49075  [show with all ESTs]
    Unigene Representative Sequence: NM_019117
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373119(uc004efa.2 uc004efb.2) ENST00000373114
    miRNA
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    Block miRNA regulation of human, mouse, rat KLHL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL4 (see all 15):
    hsa-miR-3149 hsa-miR-16-2* hsa-miR-3136-5p hsa-miR-548k hsa-miR-27a hsa-miR-526b hsa-miR-128 hsa-miR-3681*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLHL4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL4
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      QuantiTect SYBR Green Assays in human, mouse, rat KLHL4
      QuantiFast Probe-based Assays in human, mouse, rat KLHL4

    Additional mRNA sequence: 

    AB051474.1 AF284765.1 AF284766.1 AK022715.1 AK023057.1 AK056457.1 AL831868.1 AL832514.1 
    BC140839.1 BC140840.1 BC142652.1 BC146677.1 BC161675.1 

    2 DOTS entries:

    DT.40113204  DT.95137528 

    Selected AceView cDNA sequences (see all 36):

    BM718564 AF284765 AI679432 AU117238 AI675789 AI917374 AI679942 AB051474 
    AU125721 AL831868 NM_019117 AA247484 AI743832 BX281120 N64817 AL832514 
    CB108922 AU130089 AK023057 NM_057162 AK022715 AK056457 BF665986 AF284766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL4 expression in normal human tissues (normalized intensities)      KLHL4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTCTGTT
    KLHL4 Expression
    About this image


    KLHL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    KLHL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49075

    UniProtKB/Swiss-Prot: KLHL4_HUMAN, Q9C0H6
    Tissue specificity: Expressed in adult fibroblasts and in a range of fetal tissues including tongue, palate, and
    mandible

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLHL4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl41 , 5 kelch-like 4 (Drosophila)5
    kelch-like 41
    86(n)1
    88.61(a)1
      X (49.47 cM)5
    2370101  NM_172781.11  NP_766369.11 
     1144743335 
    chicken
    (Gallus gallus)
    Aves KLHL41 kelch-like 4 (Drosophila) 77.44(n)
    83.29(a)
      422265  XM_420250.4  XP_420250.2 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL46
    kelch-like family member 4
    79(a)
    1 ↔ 1
    GL343409.1(145855-184977)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhl41 kelch-like family member 4 75.36(n)
    81.03(a)
      100125035  NM_001102957.1  NP_001096427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG177543   -- 57(a)
    (best of 4)
      8D10   --


    ENSEMBL Gene Tree for KLHL4 (if available)
    TreeFam Gene Tree for KLHL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL4 gene
    KLHL172  KLHL182  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL32  
    KLHL82  KLHL102  KLHL12  KLHL22  
    Selected SIMAP similar genes for KLHL4 using alignment to 2 protein entries:     KLHL4_HUMAN (see all proteins) (see all similar genes):
    DKFZp761P1717    KLHL5    KLHL1    KLHL20    KLHL17    KLHL12
    KLHL3    KLHL28    DKFZp686H07112    KLHL18    DKFZp686P15123    KLHL8
    KLHL2    KBTBD3    KLHL10    IPP    KEAP1    KLHL9

    KLHL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL4 (see all 2270)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850396981,2
    --86739283(+) TCAAAG/TAACAT 2 -- us2k10--------
    rs1882440271,2
    C--86739378(+) TCCTAC/TCACAT 2 -- us2k10--------
    rs1473013771,2
    --86739477(+) CACACA/GCACAC 2 -- us2k10--------
    rs1916028671,2
    --86739946(+) AGGGAA/GAGGTA 2 -- us2k10--------
    rs1837841411,2
    --86740303(+) GCATTA/CTTGAT 2 -- us2k10--------
    rs1896876691,2
    --86740429(+) AAAACA/GTACTC 2 -- us2k10--------
    rs1813326811,2
    C--86740717(+) ATGTTC/TCTAAA 2 -- us2k10--------
    rs1851735581,2
    --86741006(+) AACACC/TTCGCT 2 -- us2k10--------
    rs59692291,2
    C,F,A,H--86741008(+) CACTTC/TGCTTT 2 -- us2k116Minor allele frequency- T:0.34NS EA NA WA 1967
    rs1901043171,2
    --86741051(+) TGTACG/TTTGAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLHL4 (86772715 - 86925050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KLHL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6989CNV Insertion18451855
    nsv526412CNV Gain19592680
    nsv521499CNV Gain19592680
    nsv520176CNV Gain19592680
    nsv520266CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): KLHL4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL4
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300348    OMIM disorders: --

    4 diseases for KLHL4:    About MalaCards
    mullerian aplasia    cleft palate with ankyloglossia    cleft palate    sinusitis

    1 disease from the University of Copenhagen DISEASES database for KLHL4:
    Cleft palate

    KLHL4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL4

    Export disorders for KLHL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with KLHL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of KLHL4, a novel human homologue of the Drosophila Kelch gene that maps within the X-linked cleft palate and ankyloglossia (CPX) critical region. (PubMed id 11401425)1, 2, 3 Braybrook C.... Stanier P. (Genomics 2001)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Genomic imbalances associated with mullerian aplasia. (PubMed id 18039948)1 Cheroki C....Rosenberg C. (J. Med. Genet. 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56062 HGNC: 6355 AceView: KLHL4 Ensembl:ENSG00000102271 euGenes: HUgn56062
    ECgene: KLHL4 H-InvDB: KLHL4

    (According to HUGE)
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    HUGE: KIAA1687

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLHL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL4 gene:
    Search GeneIP for patents involving KLHL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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