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Aliases for KLHL38 Gene

Aliases for KLHL38 Gene

  • Kelch Like Family Member 38 2 3 5
  • C8ORFK36 3 4
  • Kelch-Like 38 (Drosophila) 2
  • Kelch-Like Protein 38 3
  • Kelch-Like 38 3

External Ids for KLHL38 Gene

Previous GeneCards Identifiers for KLHL38 Gene

  • GC08M124730
  • GC08M119983
  • GC08M124657

Summaries for KLHL38 Gene

GeneCards Summary for KLHL38 Gene

KLHL38 (Kelch Like Family Member 38) is a Protein Coding gene. An important paralog of this gene is KLHL24.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL38 Gene

Genomics for KLHL38 Gene

Regulatory Elements for KLHL38 Gene

Enhancers for KLHL38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F123516 1.6 FANTOM5 Ensembl ENCODE 10.5 +136.2 136166 3.4 PKNOX1 SIN3A FEZF1 ZNF121 FOS SP3 JUNB TBX21 CREB3 MEF2D FBXO32 KLHL38 LOC105375738 GC08M123523 GC08M123499
GH08F123615 1.4 Ensembl ENCODE 11.5 +35.5 35462 5.0 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 CBX5 FOS KLHL38 FBXO32 LOC105375738
GH08F123579 1.2 Ensembl ENCODE 10.9 +73.0 73009 2.1 ZFP64 ARID4B ZNF48 ZNF143 FOS DEK JUNB REST TBX21 MYNN LOC105375738 KLHL38 ANXA13 FBXO32 ATAD2 WDYHV1 RN7SKP155 ENSG00000254113
GH08F123688 1.1 Ensembl ENCODE 11.2 -38.1 -38085 6.0 CBX3 SIN3A RAD21 RARA RFX5 SCRT2 DEK ZNF362 ZNF654 CEBPB ANXA13 KLHL38 ATAD2 WDYHV1 LOC105375738 FBXO32 DUTP2 MIR548AA1 RNU6-875P LOC105375739
GH08F123512 1.2 FANTOM5 ENCODE 10.1 +141.3 141269 0.8 HDAC1 PKNOX1 ATF1 TBL1XR1 TAL1 ETV1 ZBTB40 ZFHX2 FOXK2 NCOR1 FBXO32 LOC105375738 KLHL38 GC08M123499 GC08M123523
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL38 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL38 Gene

123,645,505 bp from pter
123,653,866 bp from pter
8,362 bases
Minus strand

Genomic View for KLHL38 Gene

Genes around KLHL38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL38 Gene

Proteins for KLHL38 Gene

  • Protein details for KLHL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 38
    Protein Accession:
    Secondary Accessions:
    • A0PK12

    Protein attributes for KLHL38 Gene

    581 amino acids
    Molecular mass:
    65541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL38 Gene

Post-translational modifications for KLHL38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL38 Gene

Domains & Families for KLHL38 Gene

Gene Families for KLHL38 Gene

Suggested Antigen Peptide Sequences for KLHL38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL38: view

Function for KLHL38 Gene

Gene Ontology (GO) - Molecular Function for KLHL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with KLHL38: view
genes like me logo Genes that share phenotypes with KLHL38: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL38 Gene

Localization for KLHL38 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL38 gene
Compartment Confidence
nucleus 3
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL38 Gene

Pathways & Interactions for KLHL38 Gene

SuperPathways for KLHL38 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL38: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL38 Gene

Transcripts for KLHL38 Gene

mRNA/cDNA for KLHL38 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL38 Gene

Kelch-like family member 38:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL38 Gene

No ASD Table

Relevant External Links for KLHL38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL38 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL38 Gene

This gene is overexpressed in Muscle - Skeletal (x31.9), Heart - Left Ventricle (x10.6), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for KLHL38 Gene

This gene is overexpressed in Breast (46.9) and Peripheral blood mononuclear cells (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL38 Gene

Protein tissue co-expression partners for KLHL38 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL38 Gene:


SOURCE GeneReport for Unigene cluster for KLHL38 Gene:

genes like me logo Genes that share expression patterns with KLHL38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL38 Gene

Orthologs for KLHL38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL38 34 35
  • 96.3 (n)
(Bos Taurus)
Mammalia KLHL38 34 35
  • 87.05 (n)
(Canis familiaris)
Mammalia KLHL38 34 35
  • 86.4 (n)
(Mus musculus)
Mammalia Klhl38 34 16 35
  • 84.25 (n)
(Rattus norvegicus)
Mammalia Klhl38 34
  • 83.94 (n)
(Monodelphis domestica)
Mammalia KLHL38 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL38 35
  • 71 (a)
(Gallus gallus)
Aves KLHL38 34 35
  • 72.52 (n)
(Anolis carolinensis)
Reptilia KLHL38 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl38 34
  • 66.26 (n)
(Danio rerio)
Actinopterygii klhl38a 34 35
  • 60.24 (n)
klhl38b 35
  • 51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6535 34
Species where no ortholog for KLHL38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL38 Gene

Gene Tree for KLHL38 (if available)
Gene Tree for KLHL38 (if available)

Paralogs for KLHL38 Gene

Paralogs for KLHL38 Gene

(13) SIMAP similar genes for KLHL38 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL38: view

Variants for KLHL38 Gene

Sequence variations from dbSNP and Humsavar for KLHL38 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10094484 -- 123,649,130(+) AAACT(C/T)TGAGT intron-variant
rs10109736 -- 123,651,529(+) GTCCA(A/T)GCACA intron-variant
rs10505438 -- 123,649,679(+) CCACA(A/G)ATATC intron-variant
rs10505439 -- 123,649,864(+) CAACT(C/T)CATTG intron-variant
rs10956142 -- 123,654,109(+) CAGTG(A/G)AGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHL38 Gene

Variant ID Type Subtype PubMed ID
nsv1032155 CNV loss 25217958
nsv612140 CNV loss 21841781
nsv831450 CNV gain 17160897

Variation tolerance for KLHL38 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL38 Gene

Disorders for KLHL38 Gene

Relevant External Links for KLHL38

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL38 Gene

Publications for KLHL38 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 64
  3. Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. (PMID: 25055868) Sano M. … Fukuda K. (Hum. Mol. Genet. 2014) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3 64

Products for KLHL38 Gene

Sources for KLHL38 Gene

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