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Aliases for KLHL38 Gene

Aliases for KLHL38 Gene

  • Kelch-Like Family Member 38 2 3
  • C8ORFK36 3 4
  • Kelch-Like 38 (Drosophila) 2
  • Kelch-Like Protein 38 3
  • Kelch-Like 38 3

External Ids for KLHL38 Gene

Previous GeneCards Identifiers for KLHL38 Gene

  • GC08M124730
  • GC08M119983
  • GC08M124657

Summaries for KLHL38 Gene

GeneCards Summary for KLHL38 Gene

KLHL38 (Kelch-Like Family Member 38) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL38 Gene

Genomics for KLHL38 Gene

Regulatory Elements for KLHL38 Gene

Genomic Location for KLHL38 Gene

123,645,503 bp from pter
123,653,800 bp from pter
8,298 bases
Minus strand

Genomic View for KLHL38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL38 Gene

Proteins for KLHL38 Gene

  • Protein details for KLHL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 38
    Protein Accession:
    Secondary Accessions:
    • A0PK12

    Protein attributes for KLHL38 Gene

    581 amino acids
    Molecular mass:
    65541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL38 Gene

Proteomics data for KLHL38 Gene at MOPED

Post-translational modifications for KLHL38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL38 Gene

Domains for KLHL38 Gene

Gene Families for KLHL38 Gene

Suggested Antigen Peptide Sequences for KLHL38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL38: view

Function for KLHL38 Gene

Gene Ontology (GO) - Molecular Function for KLHL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with KLHL38: view

Phenotypes for KLHL38 Gene

GenomeRNAi human phenotypes for KLHL38:
genes like me logo Genes that share phenotypes with KLHL38: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL38

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLHL38 Gene

Localization for KLHL38 Gene

Subcellular locations from

Jensen Localization Image for KLHL38 Gene COMPARTMENTS Subcellular localization image for KLHL38 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL38 Gene

Pathways for KLHL38 Gene

SuperPathways for KLHL38 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL38 Gene


No data available for Pathways by source for KLHL38 Gene

Transcripts for KLHL38 Gene

mRNA/cDNA for KLHL38 Gene

(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL38 Gene

Kelch-like family member 38:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL38

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL38 Gene

No ASD Table

Relevant External Links for KLHL38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL38 Gene

mRNA expression in normal human tissues for KLHL38 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL38 Gene

This gene is overexpressed in Muscle - Skeletal (31.9), Heart - Left Ventricle (10.6), and Heart - Atrial Appendage (4.1).

Protein differential expression in normal tissues for KLHL38 Gene

This gene is overexpressed in Breast (46.9) and Peripheral blood mononuclear cells (20.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLHL38 Gene

SOURCE GeneReport for Unigene cluster for KLHL38 Gene Hs.450252

genes like me logo Genes that share expressions with KLHL38: view

Expression partners for KLHL38 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL38 Gene

Orthologs for KLHL38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL38 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL38 35
  • 87.05 (n)
  • 86.53 (a)
KLHL38 36
  • 86 (a)
(Canis familiaris)
Mammalia KLHL38 35
  • 86.4 (n)
  • 86.75 (a)
KLHL38 36
  • 85 (a)
(Mus musculus)
Mammalia Klhl38 35
  • 84.25 (n)
  • 84.31 (a)
Klhl38 16
Klhl38 36
  • 84 (a)
(Pan troglodytes)
Mammalia KLHL38 35
  • 96.3 (n)
  • 95.23 (a)
KLHL38 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Klhl38 35
  • 83.94 (n)
  • 84.28 (a)
(Monodelphis domestica)
Mammalia KLHL38 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL38 36
  • 71 (a)
(Gallus gallus)
Aves KLHL38 35
  • 72.52 (n)
  • 71.48 (a)
KLHL38 36
  • 71 (a)
(Anolis carolinensis)
Reptilia KLHL38 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl38 35
  • 66.26 (n)
  • 67.31 (a)
(Danio rerio)
Actinopterygii klhl38a 35
  • 60.24 (n)
  • 56.63 (a)
klhl38a 36
  • 56 (a)
klhl38b 36
  • 51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6535 35
Species with no ortholog for KLHL38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL38 Gene

Gene Tree for KLHL38 (if available)
Gene Tree for KLHL38 (if available)

Paralogs for KLHL38 Gene

(13) SIMAP similar genes for KLHL38 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL38: view

Variants for KLHL38 Gene

Sequence variations from dbSNP and Humsavar for KLHL38 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1122389 -- 123,646,881(+) TGTCA(C/T)GCCCA intron-variant
rs4367519 -- 123,654,189(+) ATCTG(C/T)CTGGC upstream-variant-2KB
rs4374971 -- 123,654,047(+) CTAGC(C/T)GTCTG upstream-variant-2KB
rs4439107 -- 123,646,448(+) AGGCA(C/T)AGAAA intron-variant
rs4496951 -- 123,654,874(+) TTTTT(C/T)CTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHL38 Gene

Variant ID Type Subtype PubMed ID
nsv831450 CNV Gain 17160897

Relevant External Links for KLHL38 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL38 Gene

Disorders for KLHL38 Gene

Relevant External Links for KLHL38

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KLHL38 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLHL38 Gene

Publications for KLHL38 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  3. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for KLHL38 Gene

Sources for KLHL38 Gene

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