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Aliases for KLHL36 Gene

Aliases for KLHL36 Gene

  • Kelch-Like Family Member 36 2 3
  • C16orf44 3 4
  • Chromosome 16 Open Reading Frame 44 2
  • Kelch-Like 36 (Drosophila) 2
  • Kelch-Like Protein 36 3
  • Kelch-Like 36 3

External Ids for KLHL36 Gene

Previous Symbols for KLHL36 Gene

  • C16orf44

Summaries for KLHL36 Gene

GeneCards Summary for KLHL36 Gene

KLHL36 (Kelch-Like Family Member 36) is a Protein Coding gene. An important paralog of this gene is KLHL22.

UniProtKB/Swiss-Prot for KLHL36 Gene

  • Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL36 Gene

Genomics for KLHL36 Gene

Genomic Location for KLHL36 Gene

Start:
84,648,525 bp from pter
End:
84,667,686 bp from pter
Size:
19,162 bases
Orientation:
Plus strand

Genomic View for KLHL36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL36 Gene

Regulatory Elements for KLHL36 Gene

Proteins for KLHL36 Gene

  • Protein details for KLHL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4N3-KLH36_HUMAN
    Recommended name:
    Kelch-like protein 36
    Protein Accession:
    Q8N4N3
    Secondary Accessions:
    • Q8N5G6
    • Q9H9U6

    Protein attributes for KLHL36 Gene

    Size:
    616 amino acids
    Molecular mass:
    69896 Da
    Quaternary structure:
    • Interacts with CUL3.

    Alternative splice isoforms for KLHL36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL36 Gene

Proteomics data for KLHL36 Gene at MOPED

Post-translational modifications for KLHL36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL36 Gene

No data available for DME Specific Peptides for KLHL36 Gene

Domains for KLHL36 Gene

Gene Families for KLHL36 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4N3

UniProtKB/Swiss-Prot:

KLH36_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q8N4N3
  • Contains 1 BTB (POZ) domain.:
    • Q8N4N3
Similarity:
  • Contains 6 Kelch repeats.:
    • Q8N4N3
genes like me logo Genes that share domains with KLHL36: view

Function for KLHL36 Gene

Molecular function for KLHL36 Gene

UniProtKB/Swiss-Prot Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for KLHL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL36: view

Phenotypes for KLHL36 Gene

GenomeRNAi human phenotypes for KLHL36:
genes like me logo Genes that share phenotypes with KLHL36: view

miRNA for KLHL36 Gene

miRTarBase miRNAs that target KLHL36

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL36 Gene

Localization for KLHL36 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL36 Gene COMPARTMENTS Subcellular localization image for KLHL36 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL36 Gene

Pathways for KLHL36 Gene

SuperPathways for KLHL36 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N4N3-KLH36_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for KLHL36 Gene

Gene Ontology (GO) - Biological Process for KLHL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL36: view

No data available for Pathways by source for KLHL36 Gene

Transcripts for KLHL36 Gene

Unigene Clusters for KLHL36 Gene

Kelch-like family member 36:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for KLHL36 Gene

GeneLoc Exon Structure for
KLHL36
ECgene alternative splicing isoforms for
KLHL36

Expression for KLHL36 Gene

mRNA expression in normal human tissues for KLHL36 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL36 Gene

SOURCE GeneReport for Unigene cluster for KLHL36 Gene Hs.578546

genes like me logo Genes that share expressions with KLHL36: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL36 Gene

Orthologs for KLHL36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL36 35
  • 99.62 (n)
  • 99.84 (a)
KLHL36 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL36 35
  • 92.97 (n)
  • 94.81 (a)
KLHL36 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL36 35
  • 92.8 (n)
  • 96.59 (a)
KLHL36 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl36 35
  • 86.35 (n)
  • 85.81 (a)
Klhl36 16
Klhl36 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL36 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL36 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl36 35
  • 85.97 (n)
  • 86.62 (a)
chicken
(Gallus gallus)
Aves KLHL36 35
  • 74.96 (n)
  • 85.53 (a)
KLHL36 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl36 35
  • 68.62 (n)
  • 77.07 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4879 35
zebrafish
(Danio rerio)
Actinopterygii klhl36 35
  • 63.75 (n)
  • 63.7 (a)
klhl36 36
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
CSA.449 36
  • 31 (a)
ManyToMany
Species with no ortholog for KLHL36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL36 Gene

ENSEMBL:
Gene Tree for KLHL36 (if available)
TreeFam:
Gene Tree for KLHL36 (if available)

Paralogs for KLHL36 Gene

genes like me logo Genes that share paralogs with KLHL36: view

Variants for KLHL36 Gene

Sequence variations from dbSNP and Humsavar for KLHL36 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs867425 -- 84,665,126(+) AAACT(A/C)GAGTG utr-variant-3-prime, nc-transcript-variant
rs873856 -- 84,663,978(+) TCTGC(A/G)AGGCA utr-variant-3-prime, nc-transcript-variant
rs873857 -- 84,664,100(+) TAAAA(C/G)TCGTT utr-variant-3-prime, nc-transcript-variant
rs881583 -- 84,664,788(-) CAGTA(C/G)GGTGA utr-variant-3-prime, nc-transcript-variant
rs881584 -- 84,664,602(-) GGGTG(C/G)TCCCA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL36 Gene

Variant ID Type Subtype PubMed ID
nsv833311 CNV Loss 17160897
nsv907080 CNV Loss 21882294
nsv907081 CNV Gain 21882294

Relevant External Links for KLHL36 Gene

HapMap Linkage Disequilibrium report
KLHL36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL36 Gene

Disorders for KLHL36 Gene

Relevant External Links for KLHL36

Genetic Association Database (GAD)
KLHL36
genes like me logo Genes that share disorders with KLHL36: view

No data available for UniProtKB/Swiss-Prot for KLHL36 Gene

Publications for KLHL36 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 48
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for KLHL36 Gene

Sources for KLHL36 Gene

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