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Aliases for KLHL36 Gene

Aliases for KLHL36 Gene

  • Kelch Like Family Member 36 2 3 5
  • C16orf44 3 4
  • Chromosome 16 Open Reading Frame 44 2
  • Kelch-Like Family Member 36 3
  • Kelch-Like 36 (Drosophila) 2
  • Kelch-Like 36 3

External Ids for KLHL36 Gene

Previous HGNC Symbols for KLHL36 Gene

  • C16orf44

Previous GeneCards Identifiers for KLHL36 Gene

  • GC16P083240
  • GC16P084682
  • GC16P070437

Summaries for KLHL36 Gene

GeneCards Summary for KLHL36 Gene

KLHL36 (Kelch Like Family Member 36) is a Protein Coding gene. An important paralog of this gene is KLHL22.

UniProtKB/Swiss-Prot for KLHL36 Gene

  • Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL36 Gene

Genomics for KLHL36 Gene

Regulatory Elements for KLHL36 Gene

Enhancers for KLHL36 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL36 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL36 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL36 Gene

84,648,511 bp from pter
84,667,686 bp from pter
19,176 bases
Plus strand

Genomic View for KLHL36 Gene

Genes around KLHL36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL36 Gene

Proteins for KLHL36 Gene

  • Protein details for KLHL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 36
    Protein Accession:
    Secondary Accessions:
    • Q8N5G6
    • Q9H9U6

    Protein attributes for KLHL36 Gene

    616 amino acids
    Molecular mass:
    69896 Da
    Quaternary structure:
    • Interacts with CUL3.

    Alternative splice isoforms for KLHL36 Gene


neXtProt entry for KLHL36 Gene

Proteomics data for KLHL36 Gene at MOPED

Post-translational modifications for KLHL36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL36 Gene

No data available for DME Specific Peptides for KLHL36 Gene

Domains & Families for KLHL36 Gene

Gene Families for KLHL36 Gene

Suggested Antigen Peptide Sequences for KLHL36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL36: view

Function for KLHL36 Gene

Molecular function for KLHL36 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for KLHL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL36: view
genes like me logo Genes that share phenotypes with KLHL36: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL36 Gene

Localization for KLHL36 Gene

Subcellular locations from

Jensen Localization Image for KLHL36 Gene COMPARTMENTS Subcellular localization image for KLHL36 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL36 Gene

Pathways & Interactions for KLHL36 Gene

SuperPathways for KLHL36 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N4N3-KLH36_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for KLHL36 Gene

Gene Ontology (GO) - Biological Process for KLHL36 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHL36 Gene

Drugs & Compounds for KLHL36 Gene

No Compound Related Data Available

Transcripts for KLHL36 Gene

Unigene Clusters for KLHL36 Gene

Kelch-like family member 36:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - - - - -
SP6: -

Relevant External Links for KLHL36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL36 Gene

mRNA expression in normal human tissues for KLHL36 Gene

Protein differential expression in normal tissues from HIPED for KLHL36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4), Pancreas (11.9), Testis (10.3), and Plasma (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL36 Gene

SOURCE GeneReport for Unigene cluster for KLHL36 Gene Hs.578546

genes like me logo Genes that share expression patterns with KLHL36: view

Protein tissue co-expression partners for KLHL36 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL36 Gene

Orthologs for KLHL36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL36 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL36 35
  • 92.97 (n)
  • 94.81 (a)
KLHL36 36
  • 95 (a)
(Canis familiaris)
Mammalia KLHL36 35
  • 92.8 (n)
  • 96.59 (a)
KLHL36 36
  • 97 (a)
(Mus musculus)
Mammalia Klhl36 35
  • 86.35 (n)
  • 85.81 (a)
Klhl36 16
Klhl36 36
  • 86 (a)
(Pan troglodytes)
Mammalia KLHL36 35
  • 99.62 (n)
  • 99.84 (a)
KLHL36 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl36 35
  • 85.97 (n)
  • 86.62 (a)
(Monodelphis domestica)
Mammalia KLHL36 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL36 36
  • 87 (a)
(Gallus gallus)
Aves KLHL36 35
  • 74.96 (n)
  • 85.53 (a)
KLHL36 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl36 35
  • 68.62 (n)
  • 77.07 (a)
(Danio rerio)
Actinopterygii klhl36 35
  • 63.75 (n)
  • 63.7 (a)
klhl36 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4879 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
-- 36
  • 31 (a)
CSA.449 36
  • 31 (a)
Species with no ortholog for KLHL36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL36 Gene

Gene Tree for KLHL36 (if available)
Gene Tree for KLHL36 (if available)

Paralogs for KLHL36 Gene

genes like me logo Genes that share paralogs with KLHL36: view

Variants for KLHL36 Gene

Sequence variations from dbSNP and Humsavar for KLHL36 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9319452 -- 84,660,273(+) CCTCA(A/G)GCATG intron-variant
rs12934624 -- 84,663,542(+) GCATC(C/T)GATGG nc-transcript-variant, utr-variant-3-prime
rs12935187 -- 84,653,073(+) ttagc(C/T)gagcc intron-variant
rs12935532 -- 84,653,308(+) GCCCC(C/T)GACAA intron-variant
rs9922877 -- 84,664,122(+) TAGTC(C/T)CAGAC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL36 Gene

Variant ID Type Subtype PubMed ID
nsv833311 CNV Loss 17160897
nsv907080 CNV Loss 21882294
nsv907081 CNV Gain 21882294

Variation tolerance for KLHL36 Gene

Residual Variation Intolerance Score: 3.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLHL36 Gene

Disorders for KLHL36 Gene

Relevant External Links for KLHL36

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL36 Gene

Publications for KLHL36 Gene

  1. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KLHL36 Gene

Sources for KLHL36 Gene