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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL36 Gene

protein-coding   GIFtS: 44
GCID: GC16P084682

Kelch-Like Family Member 36

(Previous names: chromosome 16 open reading frame 44, kelch-like 36 (Drosophila))
(Previous symbol: C16orf44)
  Search for KLHL36
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 361 2
C16orf441 2 3
Chromosome 16 Open Reading Frame 441
Kelch-Like 36 (Drosophila)1
Kelch-Like 362
Kelch-Like Protein 362

External Ids:    HGNC: 178441   Entrez Gene: 797862   Ensembl: ENSG000001356867   UniProtKB: Q8N4N33   

Export aliases for KLHL36 gene to outside databases

Previous GC identifers: GC16P083240 GC16P070437


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL36 Gene: 
KLHL36 (kelch-like family member 36) is a protein-coding gene. An important paralog of this gene is KLHL42.

UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL36 gene promoter:
         AhR   Elk-1   Pax-5   Nkx2-2   Arnt   CREB   deltaCREB   c-Myc   ATF   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KLHL36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

KLHL36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL36 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084682:  view genomic region     (about GC identifiers)

Start:
84,682,131 bp from pter      End:
84,701,292 bp from pter
Size:
19,162 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3 (See protein sequence)
Recommended Name: Kelch-like protein 36  
Size: 616 amino acids; 69896 Da
Subunit: Interacts with CUL3
Secondary accessions: Q8N5G6 Q9H9U6
Alternative splicing: 2 isoforms:  Q8N4N3-1   Q8N4N3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLHL36: NX_Q8N4N3

Explore proteomics data for KLHL36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N4N3

  • KLHL36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL36 Protein Expression
    REFSEQ proteins: NP_079007.2  
    ENSEMBL proteins: 
     ENSP00000456743   ENSP00000258157   ENSP00000455244   ENSP00000455746   ENSP00000455966  

    Human Recombinant Protein Products for KLHL36: 
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    Cloud-Clone Corp. Proteins for KLHL36 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q8N4N3

    ProtoNet protein and cluster: Q8N4N3

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011498 Kelch
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH36_HUMAN, Q8N4N3
    Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the
    ubiquitination and subsequent proteasomal degradation of target proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KLHL36 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KLHL36:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL36 
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    SwitchGear 3'UTR luciferase reporter plasmidKLHL36 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL36

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    KLHL36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL36 (KLH36)

    Search CenterWatch for drugs/clinical trials and news about KLHL36 / KLH36

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL36 gene: 
    NM_024731.2  

    Unigene Cluster for KLHL36:

    Kelch-like family member 36
    Hs.578546  [show with all ESTs]
    Unigene Representative Sequence: AK074056
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564996(uc002fig.3 uc010chl.3) ENST00000258157 ENST00000567410
    ENST00000569472 ENST00000565743 ENST00000564159 ENST00000325279
    miRNA
    Products:
         
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL36 (see all 15):
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    SwitchGear 3'UTR luciferase reporter plasmidKLHL36 3' UTR sequence
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    Additional mRNA sequence: 

    AK022605.1 AK074056.1 AK122745.1 BC032400.1 BC033821.1 

    4 DOTS entries:

    DT.99995869  DT.40273441  DT.95122048  DT.91869005 

    24/144 AceView cDNA sequences (see all 144):

    BC008051 AI871638 BC033821 AU124814 AI242357 AA974595 BQ223128 AI754075 
    AW672960 H95653 BM542313 BE646123 NM_024731 BC032400 BF982609 AA780393 
    AI335839 BU176780 BQ427706 AI829973 AA810619 BI039154 BF112078 BP358924 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL36 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -     -                             -     -                     
    SP2:              -     -                       -     -     -     -               
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for KLHL36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCGCTTCG
    KLHL36 Expression
    About this image


    See KLHL36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL36

    SOURCE GeneReport for Unigene cluster: Hs.578546
        SABiosciences Custom PCR Arrays for KLHL36
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL36 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl361 , 5 kelch-like 36 (Drosophila)1, 5 86.57(n)1
    86.13(a)1
      8 (68.52 cM)5
    2347961  NM_146219.11  NP_666331.11 
     1198623055 
    chicken
    (Gallus gallus)
    Aves KLHL361 kelch-like 36 (Drosophila) 74.96(n)
    85.53(a)
      415816  XM_414178.3  XP_414178.2 
    zebrafish
    (Danio rerio)
    Actinopterygii klhl361 kelch-like 36 (Drosophila) 63.75(n)
    63.7(a)
      553604  NM_001020580.1  NP_001018416.1 


    ENSEMBL Gene Tree for KLHL36 (if available)
    TreeFam Gene Tree for KLHL36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL36 gene
    KLHL422  KLHL132  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  
    KLHL322  KLHL92  KLHL142  KLHL152  KLHDC7B2  KLHL332  KLHDC7A2  
    18/34 SIMAP similar genes for KLHL36 using alignment to 4 protein entries:     KLH36_HUMAN (see all proteins) (see all similar genes):
    FLJ00127    ZBTB4    ZBTB38    ZNF295    ZBTB7C    BACH2
    ZBTB21    HIC1    ZBTB14    KLHL2    ZNF131    NACC1
    KLHL26    BTBD9    DKFZp686L0695    KLHL13    KLHL9    ZBTB20

    KLHL36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/543 SNPs in KLHL36 are shown (see all 543)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs780583401,2
    C--70433114(+) TCCCTG/TGCACC 1 -- us2k10--------
    rs1400135171,2
    C--84680155(+) GTTCCC/TGAAAA 1 -- us2k10--------
    rs577123941,2
    C--84680265(+) TCTGGG/AGTAGG 1 -- us2k14Minor allele frequency- A:0.08WA NA EA 360
    rs1387177321,2
    C--84680347(+) AAGGG-/GAGAGAG 1 -- us2k10--------
    rs29113251,2
    C,H--84680626(+) gtgagC/Ttgaga 1 -- us2k110Minor allele frequency- T:0.03NA WA CSA EA 374
    rs99238721,2
    C,F--84680653(+) tagccG/Tgggtg 1 -- us2k11Minor allele frequency- T:0.10WA 118
    rs1902668341,2
    --84680704(+) GCTAAA/CACGGT 1 -- us2k10--------
    rs1829226561,2
    --84680839(+) GAGCCA/GAGATC 1 -- us2k10--------
    rs118601141,2
    C,F,H--84680887(+) tccgtG/Ctcaaa 1 -- us2k11Minor allele frequency- C:0.50NA 4
    rs116409181,2
    C,F,H--84680906(+) GAaaaA/Taaata 1 -- us2k1 tfbs3 trp33Minor allele frequency- T:0.25NA 8

    HapMap Linkage Disequilibrium report for KLHL36 (84682131 - 84701292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLHL36:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv907080CNV Loss21882294
    nsv833311CNV Loss17160897
    nsv907081CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KLHL36 for disorders           About MalaCards

    KLHL36 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL36

    Export disorders for KLHL36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL36 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KLHL36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    7. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. (PubMed id 14528312)2 Furukawa M.... Xiong Y. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Free Text  

      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79786 HGNC: 17844 AceView: C16orf44 Ensembl:ENSG00000135686 euGenes: HUgn79786
    ECgene: KLHL36 H-InvDB: KLHL36

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL36 gene:
    Search GeneIP for patents involving KLHL36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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