KLHL35 Gene
protein-coding GIFtS: 40
GCID: GC11M075133
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kelch-like family member 35(Previous name: kelch-like 35 (Drosophila) )
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Aliases
for KLHL35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 351 2 | | FLJ337901 | | Kelch-Like 35 (Drosophila)1 | | Kelch-Like 352 | | Kelch-Like Protein 352 |
Export aliases for KLHL35 gene to outside databasesPrevious GC identifers: GC11M074812 GC11M071430 |
Summaries
for KLHL35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHL35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL35 gene promoter:
Max1 Tal-1 Egr-1 STAT5A E47 Egr-2 c-Myb NF-Y CBF(2) c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4KLHL35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M075133: view genomic region
(about GC identifiers)
Start:
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75,133,438 bp from pter |
End:
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75,141,674 bp from pter |
Size:
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8,237 bases |
Orientation:
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minus strand |
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Proteins
for KLHL35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH35_HUMAN, Q6PF15 (See
protein sequence)Recommended Name: Kelch-like protein 35 Size: 363 amino acids; 40026 Da
Sequence caution: Sequence=AAH57763.1; Type=Erroneous initiation;
Secondary accessions: A2RU06 Q86XM7 Q8NBB1Alternative splicing: 2 isoforms: Q6PF15-1 Q6PF15-2 Explore the universe of human proteins at neXtProt for KLHL35: NX_Q6PF15
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PF15
KLHL35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034637.2
ENSEMBL proteins: ENSP00000365469 ENSP00000438526
Human Recombinant Protein Products for KLHL35:
KLHL35 Antibody Products:
Assay Products for KLHL35: |
Protein
Domains /
Families
for KLHL35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL35 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PF15ProtoNet protein and cluster: Q6PF15 1 Blocks protein family: IPB011498 Kelch
UniProtKB/Swiss-Prot: KLH35_HUMAN, Q6PF15Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL35 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL35 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHL35 (NM_001039548) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL35 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL35 |
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Pathways & Interactions
for KLHL35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL35
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/9 Interacting proteins for KLHL35 (Q6PF153 ENSP000003654694) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for KLHL35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL35
Search CenterWatch for drugs/clinical trials and news about KLHL35 / KLH35
|
Transcripts
for KLHL35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL35 gene (2 alternative transcripts): NM_173583.1 NM_001039548.2 Unigene Cluster for KLHL35: Kelch-like 35 (Drosophila) Hs.292451 [show with all ESTs]Unigene Representative Sequence: AL0503705 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376292 ENST00000441792 ENST00000460787 ENST00000527491 ENST00000539798(uc001owm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL35 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL35 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL35 (NM_001039548) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL35 |
Additional cDNA sequence: AK091109.1 AL050370.1 BC042952.2 BC057763.1 BC131539.1 BC132708.1 BC132710.1 7 DOTS entries: DT.97785683 DT.100734989 DT.100021015 DT.86851826 DT.75102790 DT.75102791 DT.100667923 24/69 AceView cDNA sequences (see all 69): W95746 AW128925 BQ631932 AI183718 BC042952 BC057763 BX404788 AW128926 BM707441 NM_173583 AI380675 BU624654 AI889211 BQ632228 BE218891 AX746783 AA364095 AK091109 BI550917 BI464945 AI128811 BF445167 BF448703 AW134615
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL35 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 |
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| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLHL35
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Expression
for KLHL35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACCTCCAC
About this image
See KLHL35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL35
SOURCE GeneReport for Unigene cluster: Hs.292451
SABiosciences Custom PCR Arrays for KLHL35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL35 |
Orthologs
for KLHL35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLHL35 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for KLHL35 (if available)
TreeFam Gene Tree for KLHL35 (if available) |
Paralogs
for KLHL35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL35 gene
- KLHL382 KLHL212 KLHL292 KLHL62 KLHL232 KBTBD32 KLHL112 KLHL242
- KLHL252 KLHL302 ENC12 CCIN2
15 SIMAP similar genes for KLHL35 using alignment to 2 protein entries: KLH35_HUMAN (see all proteins):ZBTB7C FLJ00029 KLHL24 KLHL6 KBTBD8 KLHL17
KLHL29 KLHL20 KLHL12 ZBTB21 ENC1 KLHL1
KLHL21 KLHL25 KLHL3
KLHL35 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL35 (75133438 - 75141674 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHL35: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL35 |
|
Disorders
/ Diseases
for KLHL35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KLHL35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL35 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHL35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KLHL35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KLHL35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL35 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KLHL35 gene:
Search GeneIP for patents involving KLHL35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL35 | | | OriGene Protein Over-expression Lysate for KLHL35 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for KLHL35 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL35 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL35 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for KLHL35 |
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 | | | KLHL35 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL35 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KLHL35 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL35 |
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