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Aliases for KLHL35 Gene

Aliases for KLHL35 Gene

  • Kelch-Like Family Member 35 2 3
  • Kelch-Like 35 (Drosophila) 2

External Ids for KLHL35 Gene

Previous GeneCards Identifiers for KLHL35 Gene

  • GC11M074812
  • GC11M075133
  • GC11M071430

Summaries for KLHL35 Gene

GeneCards Summary for KLHL35 Gene

KLHL35 (Kelch-Like Family Member 35) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL35 Gene

Genomics for KLHL35 Gene

Regulatory Elements for KLHL35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL35 Gene

Chromosome:
11
Start:
75,422,394 bp from pter
End:
75,433,444 bp from pter
Size:
11,051 bases
Orientation:
Minus strand

Genomic View for KLHL35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL35 Gene

Proteins for KLHL35 Gene

  • Protein details for KLHL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF15-KLH35_HUMAN
    Recommended name:
    Kelch-like protein 35
    Protein Accession:
    Q6PF15
    Secondary Accessions:
    • A2RU06
    • F5H412
    • Q86XM7
    • Q8NBB1

    Protein attributes for KLHL35 Gene

    Size:
    583 amino acids
    Molecular mass:
    62892 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH42952.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH57763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32711.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03585.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW74965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW74966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL35 Gene

Proteomics data for KLHL35 Gene at MOPED

Post-translational modifications for KLHL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL35 Gene

Domains & Families for KLHL35 Gene

Gene Families for KLHL35 Gene

Protein Domains for KLHL35 Gene

Suggested Antigen Peptide Sequences for KLHL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PF15

UniProtKB/Swiss-Prot:

KLH35_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL35: view

Function for KLHL35 Gene

Gene Ontology (GO) - Molecular Function for KLHL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLHL35: view

Phenotypes for KLHL35 Gene

GenomeRNAi human phenotypes for KLHL35:
genes like me logo Genes that share phenotypes with KLHL35: view

miRNA for KLHL35 Gene

miRTarBase miRNAs that target KLHL35

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL35

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL35 Gene

Localization for KLHL35 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL35 Gene COMPARTMENTS Subcellular localization image for KLHL35 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL35 Gene

Pathways & Interactions for KLHL35 Gene

SuperPathways for KLHL35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KLHL35 Gene

Drugs & Compounds for KLHL35 Gene

No Compound Related Data Available

Transcripts for KLHL35 Gene

Unigene Clusters for KLHL35 Gene

Kelch-like family member 35:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL35

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -
SP2:
SP3:

Relevant External Links for KLHL35 Gene

GeneLoc Exon Structure for
KLHL35
ECgene alternative splicing isoforms for
KLHL35

Expression for KLHL35 Gene

mRNA expression in normal human tissues for KLHL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL35 Gene

This gene is overexpressed in Testis (x5.1), Brain - Nucleus accumbens (basal ganglia) (x4.9), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for KLHL35 Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL35 Gene



SOURCE GeneReport for Unigene cluster for KLHL35 Gene Hs.292451

genes like me logo Genes that share expression patterns with KLHL35: view

Protein tissue co-expression partners for KLHL35 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLHL35 Gene

Orthologs for KLHL35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL35 35
  • 87.7 (n)
  • 90 (a)
KLHL35 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL35 35
  • 89.71 (n)
  • 89.31 (a)
KLHL35 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl35 35
  • 87.24 (n)
  • 90.48 (a)
Klhl35 16
Klhl35 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL35 35
  • 99.54 (n)
  • 99.14 (a)
KLHL35 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl35 35
  • 86.26 (n)
  • 88.17 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHL35 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC769507 35
  • 63.84 (n)
  • 58.66 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia KLHL35 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl35 35
  • 58.48 (n)
  • 53.82 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570873 35
  • 57.23 (n)
  • 47.01 (a)
klhl35 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for KLHL35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL35 Gene

ENSEMBL:
Gene Tree for KLHL35 (if available)
TreeFam:
Gene Tree for KLHL35 (if available)

Paralogs for KLHL35 Gene

(10) SIMAP similar genes for KLHL35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLHL35: view

Variants for KLHL35 Gene

Sequence variations from dbSNP and Humsavar for KLHL35 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs499745 -- 75,429,002(-) TTAAT(A/G)GCTTT intron-variant
rs525084 -- 75,432,749(+) GGGTC(A/G)AACGA intron-variant
rs532798 -- 75,431,178(+) gggag(A/G)gaggg upstream-variant-2KB, intron-variant
rs538451 -- 75,431,822(+) CGAGC(A/T)ACATG upstream-variant-2KB, intron-variant
rs539199 -- 75,431,873(+) ACACT(G/T)TGTGT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL35 Gene

Variant ID Type Subtype PubMed ID
nsv897920 CNV Loss 21882294
dgv1224n71 CNV Loss 21882294
nsv897923 CNV Loss 21882294

Variation tolerance for KLHL35 Gene

Gene Damage Index Score: 2.03; 37.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL35 Gene

HapMap Linkage Disequilibrium report
KLHL35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL35 Gene

Disorders for KLHL35 Gene

Relevant External Links for KLHL35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL35
genes like me logo Genes that share disorders with KLHL35: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL35 Gene

Publications for KLHL35 Gene

  1. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 67
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 67

Products for KLHL35 Gene

Sources for KLHL35 Gene

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