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Aliases for KLHL35 Gene

Aliases for KLHL35 Gene

  • Kelch-Like Family Member 35 2 3
  • Kelch-Like 35 (Drosophila) 2

External Ids for KLHL35 Gene

Previous GeneCards Identifiers for KLHL35 Gene

  • GC11M074812
  • GC11M075133
  • GC11M071430

Summaries for KLHL35 Gene

GeneCards Summary for KLHL35 Gene

KLHL35 (Kelch-Like Family Member 35) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL35 Gene

Genomics for KLHL35 Gene

Regulatory Elements for KLHL35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL35 Gene

75,422,394 bp from pter
75,430,629 bp from pter
8,236 bases
Minus strand

Genomic View for KLHL35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL35 Gene

Proteins for KLHL35 Gene

  • Protein details for KLHL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 35
    Protein Accession:
    Secondary Accessions:
    • A2RU06
    • F5H412
    • Q86XM7
    • Q8NBB1

    Protein attributes for KLHL35 Gene

    583 amino acids
    Molecular mass:
    62892 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH42952.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH57763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32711.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03585.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW74965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW74966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL35 Gene


neXtProt entry for KLHL35 Gene

Proteomics data for KLHL35 Gene at MOPED

Post-translational modifications for KLHL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL35 Gene

Domains for KLHL35 Gene

Gene Families for KLHL35 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Protein Domains for KLHL35 Gene

Suggested Antigen Peptide Sequences for KLHL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6PF15
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL35: view

Function for KLHL35 Gene

Gene Ontology (GO) - Molecular Function for KLHL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLHL35: view

Animal Model Products

CRISPR Products

miRNA for KLHL35 Gene

miRTarBase miRNAs that target KLHL35

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL35

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL35 Gene

Localization for KLHL35 Gene

Subcellular locations from

Jensen Localization Image for KLHL35 Gene COMPARTMENTS Subcellular localization image for KLHL35 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL35 Gene

Pathways for KLHL35 Gene

SuperPathways for KLHL35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL35 Gene


No data available for Pathways by source for KLHL35 Gene

Transcripts for KLHL35 Gene

Unigene Clusters for KLHL35 Gene

Kelch-like family member 35:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL35

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLHL35

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -

Relevant External Links for KLHL35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL35 Gene

mRNA expression in normal human tissues for KLHL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL35 Gene

This gene is overexpressed in Testis (5.1), Brain - Nucleus accumbens (basal ganglia) (4.9), and Brain - Putamen (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLHL35 Gene

SOURCE GeneReport for Unigene cluster for KLHL35 Gene Hs.292451

genes like me logo Genes that share expressions with KLHL35: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLHL35 Gene

Orthologs for KLHL35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL35 35
  • 99.54 (n)
  • 99.14 (a)
KLHL35 36
  • 99 (a)
(Bos Taurus)
Mammalia KLHL35 35
  • 87.7 (n)
  • 90 (a)
KLHL35 36
  • 90 (a)
(Canis familiaris)
Mammalia KLHL35 35
  • 89.71 (n)
  • 89.31 (a)
KLHL35 36
  • 89 (a)
(Mus musculus)
Mammalia Klhl35 35
  • 87.24 (n)
  • 90.48 (a)
Klhl35 16
Klhl35 36
  • 90 (a)
(Monodelphis domestica)
Mammalia KLHL35 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Klhl35 35
  • 86.26 (n)
  • 88.17 (a)
(Gallus gallus)
Aves -- 36
  • 56 (a)
-- 36
  • 65 (a)
LOC769507 35
  • 63.84 (n)
  • 58.66 (a)
(Anolis carolinensis)
Reptilia KLHL35 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl35 35
  • 58.48 (n)
  • 53.82 (a)
(Danio rerio)
Actinopterygii klhl35 36
  • 46 (a)
LOC570873 35
  • 57.23 (n)
  • 47.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for KLHL35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL35 Gene

Gene Tree for KLHL35 (if available)
Gene Tree for KLHL35 (if available)

Paralogs for KLHL35 Gene

Selected SIMAP similar genes for KLHL35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLHL35: view

Variants for KLHL35 Gene

Sequence variations from dbSNP and Humsavar for KLHL35 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs499745 -- 75,429,002(-) TTAAT(A/G)GCTTT intron-variant
rs532798 -- 75,431,178(+) gggag(A/G)gaggg upstream-variant-2KB
rs538451 -- 75,431,822(+) CGAGC(A/T)ACATG upstream-variant-2KB
rs539199 -- 75,431,873(+) ACACT(G/T)TGTGT upstream-variant-2KB
rs542276 -- 75,430,913(+) TCAAA(C/T)AGGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHL35 Gene

Variant ID Type Subtype PubMed ID
nsv897920 CNV Loss 21882294
dgv1224n71 CNV Loss 21882294
nsv897923 CNV Loss 21882294

Relevant External Links for KLHL35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL35 Gene

Disorders for KLHL35 Gene

No disorders were found for KLHL35 Gene.

No data available for UniProtKB/Swiss-Prot for KLHL35 Gene

Publications for KLHL35 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  3. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for KLHL35 Gene

Sources for KLHL35 Gene

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