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KLHL35 Gene

protein-coding   GIFtS: 44
GCID: GC11M075133

Kelch-Like Family Member 35

(Previous name: kelch-like 35 (Drosophila))
  Search for KLHL35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 351 2
Kelch-Like 35 (Drosophila)1
Kelch-Like 352
Kelch-Like Protein 352

External Ids:    HGNC: 265971   Entrez Gene: 2832122   Ensembl: ENSG000001492437   UniProtKB: Q6PF153   

Export aliases for KLHL35 gene to outside databases

Previous GC identifers: GC11M074812 GC11M071430


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL35 Gene:
KLHL35 (kelch-like family member 35) is a protein-coding gene. An important paralog of this gene is KLHL21.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL35 gene promoter:
         Max1   Tal-1   Egr-1   STAT5A   E47   Egr-2   c-Myb   NF-Y   CBF(2)   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KLHL35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

KLHL35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL35 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M075133:  view genomic region     (about GC identifiers)

Start:
75,133,438 bp from pter      End:
75,141,674 bp from pter
Size:
8,237 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLH35_HUMAN, Q6PF15 (See protein sequence)
Recommended Name: Kelch-like protein 35  
Size: 363 amino acids; 40026 Da
Sequence caution: Sequence=AAH57763.1; Type=Erroneous initiation;
Secondary accessions: A2RU06 Q86XM7 Q8NBB1
Alternative splicing: 2 isoforms:  Q6PF15-1   Q6PF15-2   

Explore the universe of human proteins at neXtProt for KLHL35: NX_Q6PF15

Explore proteomics data for KLHL35 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHL35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001034637.2  
    ENSEMBL proteins: 
     ENSP00000365469   ENSP00000438526  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    3 InterPro protein domains:
     IPR006652 Kelch_1
     IPR015916 Gal_Oxidase_b-propeller
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q6PF15

    ProtoNet protein and cluster: Q6PF15

    1 Blocks protein domain: IPB011498 Kelch

    UniProtKB/Swiss-Prot: KLH35_HUMAN, Q6PF15
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 6 Kelch repeats


    KLHL35 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KLHL35 for ontologies           About GeneDecksing


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    hsa-mir-335-5p (MIRT018223)

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    hsa-miR-24
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL35
    Interactions:

        Search GeneGlobe Interaction Network for KLHL35

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for KLHL35 (Q6PF153 ENSP000003654694) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    TGFBR1P368973, ENSP000003641334I2D: score=4 STRING: ENSP00000364133
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL35 (KLH35)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLHL35 gene (2 alternative transcripts): 
    NM_173583.1  NM_001039548.2  

    Unigene Cluster for KLHL35:

    Kelch-like family member 35
    Hs.292451  [show with all ESTs]
    Unigene Representative Sequence: AL050370
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376292 ENST00000460787 ENST00000527491 ENST00000539798(uc001owm.2)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate KLHL35:
    hsa-miR-24
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    Additional mRNA sequence: 

    AK091109.1 AL050370.1 BC042952.2 BC057763.1 BC131539.1 BC132708.1 BC132710.1 

    7 DOTS entries:

    DT.97785683  DT.100734989  DT.100021015  DT.86851826  DT.75102790  DT.75102791  DT.100667923 

    Selected AceView cDNA sequences (see all 69):

    BU624654 AK091109 AW128925 W95746 AW128926 AA364095 BM707441 AI889211 
    BC057763 AI380675 AX746783 NM_173583 AI183718 BQ632228 BC042952 BX404788 
    BQ631932 BE218891 AW449017 AL050370 AA976210 AI432356 AA971368 BX447389 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL35    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:              -                       -                           
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for KLHL35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCTCCAC
    KLHL35 Expression
    About this image


    KLHL35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    KLHL35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292451
        Custom PCR Arrays for KLHL35
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL35 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl351 , 5 kelch-like 35 (Drosophila)5
    kelch-like 351
    87.24(n)1
    90.48(a)1
      7 (54.07 cM)5
    721841  NM_028145.11  NP_082421.11 
     994660045 
    chicken
    (Gallus gallus)
    Aves LOC7695071 kelch-like protein 35-like 63.84(n)
    58.66(a)
      769507  XM_004938995.1  XP_004939052.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL356
    kelch-like family member 35
    53(a)
    1 ↔ 1
    GL343298.1(1066119-1077843)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhl351 kelch-like family member 35 58.48(n)
    53.82(a)
      100486151  XM_002941162.2  XP_002941208.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5708731 kelch-like protein 24-like 57.23(n)
    47.01(a)
      570873  XM_694398.5  XP_699490.4 


    ENSEMBL Gene Tree for KLHL35 (if available)
    TreeFam Gene Tree for KLHL35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL35 gene
    KLHL212  KLHL62  KBTBD82  KLHL412  KBTBD122  KBTBD22  KLHL242  ENC12  
    KLHL382  KLHL292  KBTBD32  KLHL232  KLHL402  KBTBD72  KLHL302  KBTBD62  
    KLHL252  
    10 SIMAP similar genes for KLHL35 using alignment to 2 protein entries:     KLH35_HUMAN (see all proteins):
    ZBTB7C    FLJ00029    KLHL24    KLHL6    KBTBD8    KLHL17
    KLHL29    KLHL20    KLHL12    ZBTB21

    KLHL35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL35 (see all 218)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122767911,2
    C,F,H--75133885(+) GGCCAG/CATAAT 1 -- int18Minor allele frequency- C:0.02NS EA NA WA 542
    rs1901611281,2
    --75133993(+) AGTGAA/CTGGCG 1 -- int10--------
    rs1128629071,2
    C,F--75133998(+) ATGGCG/ATTAGG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1159199041,2
    C,F--75134245(+) CAGAGA/GCCTCC 1 -- int11Minor allele frequency- G:0.10WA 118
    rs1499797431,2
    --75134362(+) CTCTGA/GTATCA 1 -- int10--------
    rs1142911091,2
    F--75134436(+) CCTTCG/AGGGCA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1442449801,2
    --75134475(+) ATCCCC/TACTCA 1 -- int10--------
    rs2022156231,2
    C--75134735(+) ACTTAC/GCACAG 1 -- spd10--------
    rs1823837261,2
    C--75134852(+) AGCCTC/G/TGAGAC 3 K Q E mis10--------
    rs2012872461,2
    C--75134905(+) CCTCCT/CTGGGG 2 /K /R mis11Minor allele frequency- C:0.00EU 569

    HapMap Linkage Disequilibrium report for KLHL35 (75133438 - 75141674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLHL35:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1224n71CNV Loss21882294
    nsv897923CNV Loss21882294
    nsv897920CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL35 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KLHL35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283212 HGNC: 26597 AceView: FLJ33790 Ensembl:ENSG00000149243 euGenes: HUgn283212
    ECgene: KLHL35 H-InvDB: KLHL35

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL35 gene:
    Search GeneIP for patents involving KLHL35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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