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Aliases for KLHL35 Gene

Aliases for KLHL35 Gene

  • Kelch Like Family Member 35 2 3 5
  • Kelch-Like 35 (Drosophila) 2

External Ids for KLHL35 Gene

Previous GeneCards Identifiers for KLHL35 Gene

  • GC11M074812
  • GC11M075133
  • GC11M071430

Summaries for KLHL35 Gene

GeneCards Summary for KLHL35 Gene

KLHL35 (Kelch Like Family Member 35) is a Protein Coding gene. An important paralog of this gene is KLHL24.

Additional gene information for KLHL35 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL35 Gene

Genomics for KLHL35 Gene

Regulatory Elements for KLHL35 Gene

Enhancers for KLHL35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H075398 1.2 ENCODE 28.9 +32.2 32153 4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLD3 KLHL35 RNF169 RPS3 SERPINH1 ENSG00000254460 ENSG00000254630 OR2AT1P LOC283214 UVRAG
GH11H075474 1.2 Ensembl ENCODE 18.9 -42.5 -42499 2 HDGF PKNOX1 PTBP1 NFIB ARNT ZNF195 NFXL1 GLI4 EGR1 ZNF350 EMSY KLHL35 GDPD5 LOC105369391 POLD3 SERPINH1 ENSG00000254837 PIR48197 ENSG00000254460 GC11M075443
GH11H075417 1.2 Ensembl ENCODE 18.3 +12.5 12528 6 PKNOX1 FOXA2 MLX ARID4B SIN3A YY1 TCF12 GATA2 FOS SP5 KLHL35 RPS3 ENSG00000254837 GC11M075423 SNORD15B
GH11H075327 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +93.0 92958 26 MLX DMAP1 YY1 ZNF143 SP3 NFYC GLIS1 RCOR2 NBN NR2C1 POLD3 GDPD5 ARRB1 SNORD15B KLHL35 XRRA1 RNF169 NEU3 RPS3 ENSG00000254974
GH11H075427 1.1 Ensembl ENCODE 18.2 +4.0 4035 3 TBP ARID4B SIN3A NFYA NFYC ELF1 REST SP1 MTA1 ZBTB26 KLHL35 GC11M075423
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL35 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL35 Gene

Chromosome:
11
Start:
75,422,394 bp from pter
End:
75,433,444 bp from pter
Size:
11,051 bases
Orientation:
Minus strand

Genomic View for KLHL35 Gene

Genes around KLHL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL35 Gene

Proteins for KLHL35 Gene

  • Protein details for KLHL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF15-KLH35_HUMAN
    Recommended name:
    Kelch-like protein 35
    Protein Accession:
    Q6PF15
    Secondary Accessions:
    • A2RU06
    • F5H412
    • Q86XM7
    • Q8NBB1

    Protein attributes for KLHL35 Gene

    Size:
    583 amino acids
    Molecular mass:
    62892 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH42952.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH57763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32711.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03585.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW74965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW74966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL35 Gene

Post-translational modifications for KLHL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL35 Gene

Domains & Families for KLHL35 Gene

Gene Families for KLHL35 Gene

Suggested Antigen Peptide Sequences for KLHL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL35: view

No data available for UniProtKB/Swiss-Prot for KLHL35 Gene

Function for KLHL35 Gene

Phenotypes From GWAS Catalog for KLHL35 Gene

Gene Ontology (GO) - Molecular Function for KLHL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLHL35: view
genes like me logo Genes that share phenotypes with KLHL35: view

Animal Model Products

CRISPR Products

miRNA for KLHL35 Gene

miRTarBase miRNAs that target KLHL35

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLHL35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL35 Gene

Localization for KLHL35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL35 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL35 Gene

Pathways & Interactions for KLHL35 Gene

SuperPathways for KLHL35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL35: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL35 Gene

Drugs & Compounds for KLHL35 Gene

No Compound Related Data Available

Transcripts for KLHL35 Gene

Unigene Clusters for KLHL35 Gene

Kelch-like family member 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLHL35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -
SP2:
SP3:

Relevant External Links for KLHL35 Gene

GeneLoc Exon Structure for
KLHL35
ECgene alternative splicing isoforms for
KLHL35

Expression for KLHL35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL35 Gene

This gene is overexpressed in Testis (x5.1), Brain - Nucleus accumbens (basal ganglia) (x4.9), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for KLHL35 Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL35 Gene



Protein tissue co-expression partners for KLHL35 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL35 Gene:

KLHL35

SOURCE GeneReport for Unigene cluster for KLHL35 Gene:

Hs.292451

Evidence on tissue expression from TISSUES for KLHL35 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KLHL35: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL35 Gene

Orthologs for KLHL35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL35 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia KLHL35 33 34
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia KLHL35 33 34
  • 87.7 (n)
mouse
(Mus musculus)
Mammalia Klhl35 33 16 34
  • 87.24 (n)
rat
(Rattus norvegicus)
Mammalia Klhl35 33
  • 86.26 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL35 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 65 (a)
OneToMany
LOC769507 33
  • 63.84 (n)
-- 34
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia KLHL35 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl35 33
  • 58.48 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570873 33
  • 57.23 (n)
klhl35 34
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for KLHL35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL35 Gene

ENSEMBL:
Gene Tree for KLHL35 (if available)
TreeFam:
Gene Tree for KLHL35 (if available)

Paralogs for KLHL35 Gene

Paralogs for KLHL35 Gene

(10) SIMAP similar genes for KLHL35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLHL35: view

Variants for KLHL35 Gene

Sequence variations from dbSNP and Humsavar for KLHL35 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000001078 -- 75,426,460(+) TCCCT(C/G)CAGCA intron-variant
rs1000280427 -- 75,426,692(+) AGCAC(C/T)CCCAA intron-variant
rs1000788689 -- 75,433,730(+) AGGGC(C/T)GGTCC utr-variant-5-prime
rs1000842286 -- 75,430,322(+) CGGCC(A/G)GCGCC reference, missense
rs1000905085 -- 75,433,511(+) TGCGT(C/G/T)ATTGT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL35 Gene

Variant ID Type Subtype PubMed ID
nsv1070973 CNV deletion 25765185

Variation tolerance for KLHL35 Gene

Gene Damage Index Score: 2.03; 37.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL35 Gene

Disorders for KLHL35 Gene

Relevant External Links for KLHL35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL35

No disorders were found for KLHL35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL35 Gene

Publications for KLHL35 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho CE … Valentini SR (Experimental cell research 2015) 3 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa BS … Friedman JS (Human genomics 2013) 3 60
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60

Products for KLHL35 Gene

Sources for KLHL35 Gene

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