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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL35 Gene

protein-coding   GIFtS: 42
GCID: GC11M075133

Kelch-Like Family Member 35

(Previous name: kelch-like 35 (Drosophila))
  Search for KLHL35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 351 2
Kelch-Like 35 (Drosophila)1
Kelch-Like 352
Kelch-Like Protein 352

External Ids:    HGNC: 265971   Entrez Gene: 2832122   Ensembl: ENSG000001492437   UniProtKB: Q6PF153   

Export aliases for KLHL35 gene to outside databases

Previous GC identifers: GC11M074812 GC11M071430


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL35 Gene: 
KLHL35 (kelch-like family member 35) is a protein-coding gene. An important paralog of this gene is KLHL21.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL35 gene promoter:
         Max1   Tal-1   Egr-1   STAT5A   E47   Egr-2   c-Myb   NF-Y   CBF(2)   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KLHL35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

KLHL35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL35 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M075133:  view genomic region     (about GC identifiers)

Start:
75,133,438 bp from pter      End:
75,141,674 bp from pter
Size:
8,237 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH35_HUMAN, Q6PF15 (See protein sequence)
Recommended Name: Kelch-like protein 35  
Size: 363 amino acids; 40026 Da
Sequence caution: Sequence=AAH57763.1; Type=Erroneous initiation;
Secondary accessions: A2RU06 Q86XM7 Q8NBB1
Alternative splicing: 2 isoforms:  Q6PF15-1   Q6PF15-2   

Explore the universe of human proteins at neXtProt for KLHL35: NX_Q6PF15

Explore proteomics data for KLHL35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PF15

  • KLHL35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL35 Protein Expression
    REFSEQ proteins: NP_001034637.2  
    ENSEMBL proteins: 
     ENSP00000365469   ENSP00000438526  

    Human Recombinant Protein Products for KLHL35: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    3 InterPro protein domains:
     IPR006652 Kelch_1
     IPR015916 Gal_Oxidase_b-propeller
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q6PF15

    ProtoNet protein and cluster: Q6PF15

    1 Blocks protein domain: IPB011498 Kelch

    UniProtKB/Swiss-Prot: KLH35_HUMAN, Q6PF15
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 6 Kelch repeats


    KLHL35 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KLHL35 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL35

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/9 Interacting proteins for KLHL35 (Q6PF153 ENSP000003654694) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    TGFBR1P368973, ENSP000003641334I2D: score=4 STRING: ENSP00000364133
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL35 (KLH35)

    Search CenterWatch for drugs/clinical trials and news about KLHL35 / KLH35

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL35 gene (2 alternative transcripts): 
    NM_173583.1  NM_001039548.2  

    Unigene Cluster for KLHL35:

    Kelch-like family member 35
    Hs.292451  [show with all ESTs]
    Unigene Representative Sequence: AL050370
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376292 ENST00000460787 ENST00000527491 ENST00000539798(uc001owm.2)

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    hsa-miR-24
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AK091109.1 AL050370.1 BC042952.2 BC057763.1 BC131539.1 BC132708.1 BC132710.1 

    7 DOTS entries:

    DT.97785683  DT.100734989  DT.100021015  DT.86851826  DT.75102790  DT.75102791  DT.100667923 

    24/69 AceView cDNA sequences (see all 69):

    NM_173583 BC042952 BE218891 BQ632228 AI380675 AW128925 AX746783 AW128926 
    AA364095 BX404788 BQ631932 AK091109 AI889211 W95746 AI183718 BU624654 
    BC057763 BM707441 BX447389 BI550917 BX451745 BF508287 AL050370 AI348451 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL35    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:              -                       -                           
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for KLHL35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL35 expression in normal human tissues (normalized intensities)      KLHL35 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCTCCAC
    KLHL35 Expression
    About this image


    KLHL35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer

    See KLHL35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL35

    SOURCE GeneReport for Unigene cluster: Hs.292451
        SABiosciences Custom PCR Arrays for KLHL35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL35 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl351 , 5 kelch-like 35 (Drosophila)1, 5 87.54(n)1
    91.01(a)1
      7 (54.07 cM)5
    721841  NM_028145.11  NP_082421.11 
     994660045 
    chicken
    (Gallus gallus)
    Aves LOC7695071 kelch-like protein 35-like 64.14(n)
    58.84(a)
      769507  XM_003640626.1  XP_003640674.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL356
    kelch-like family member 35
    52(a)
    1 ↔ 1
    GL343298.1(1066119-1077843)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5708731 kelch-like protein 24-like 57.23(n)
    47.19(a)
      570873  XM_694398.4  XP_699490.4 


    ENSEMBL Gene Tree for KLHL35 (if available)
    TreeFam Gene Tree for KLHL35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL35 gene
    KLHL212  KLHL62  KBTBD82  KLHL412  KBTBD122  KLHL242  KBTBD22  ENC12  
    KLHL382  KLHL292  KBTBD32  KLHL232  KLHL402  KLHL72  KBTBD72  KLHL302  
    KBTBD62  KLHL252  
    10 SIMAP similar genes for KLHL35 using alignment to 2 protein entries:     KLH35_HUMAN (see all proteins):
    ZBTB7C    FLJ00029    KLHL24    KLHL6    KBTBD8    KLHL17
    KLHL29    KLHL20    KLHL12    ZBTB21

    KLHL35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/218 SNPs in KLHL35 are shown (see all 218)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122767911,2
    C,F,H--75133885(+) GGCCAG/CATAAT 1 -- int18Minor allele frequency- C:0.02NS EA NA WA 542
    rs1901611281,2
    --75133993(+) AGTGAA/CTGGCG 1 -- int10--------
    rs1128629071,2
    C,F--75133998(+) ATGGCG/ATTAGG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1159199041,2
    C,F--75134245(+) CAGAGA/GCCTCC 1 -- int11Minor allele frequency- G:0.10WA 118
    rs1499797431,2
    --75134362(+) CTCTGA/GTATCA 1 -- int10--------
    rs1142911091,2
    F--75134436(+) CCTTCG/AGGGCA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1442449801,2
    --75134475(+) ATCCCC/TACTCA 1 -- int10--------
    rs2022156231,2
    C--75134735(+) ACTTAC/GCACAG 1 -- spd10--------
    rs1823837261,2
    C--75134852(+) AGCCTC/G/TGAGAC 3 K Q E mis10--------
    rs2012872461,2
    C--75134905(+) CCTCCT/CTGGGG 2 /K /R mis11Minor allele frequency- C:0.00EU 569

    HapMap Linkage Disequilibrium report for KLHL35 (75133438 - 75141674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLHL35:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1224n71CNV Loss21882294
    nsv897923CNV Loss21882294
    nsv897920CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL35 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KLHL35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283212 HGNC: 26597 AceView: FLJ33790 Ensembl:ENSG00000149243 euGenes: HUgn283212
    ECgene: KLHL35 H-InvDB: KLHL35

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL35 gene:
    Search GeneIP for patents involving KLHL35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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