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Aliases for KLHL35 Gene

Aliases for KLHL35 Gene

  • Kelch Like Family Member 35 2 3 5
  • Kelch-Like 35 (Drosophila) 2

External Ids for KLHL35 Gene

Previous GeneCards Identifiers for KLHL35 Gene

  • GC11M074812
  • GC11M075133
  • GC11M071430

Summaries for KLHL35 Gene

GeneCards Summary for KLHL35 Gene

KLHL35 (Kelch Like Family Member 35) is a Protein Coding gene. An important paralog of this gene is KBTBD4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL35 Gene

Genomics for KLHL35 Gene

Regulatory Elements for KLHL35 Gene

Genomic Location for KLHL35 Gene

75,422,394 bp from pter
75,433,444 bp from pter
11,051 bases
Minus strand

Genomic View for KLHL35 Gene

Genes around KLHL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL35 Gene

Proteins for KLHL35 Gene

  • Protein details for KLHL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 35
    Protein Accession:
    Secondary Accessions:
    • A2RU06
    • F5H412
    • Q86XM7
    • Q8NBB1

    Protein attributes for KLHL35 Gene

    583 amino acids
    Molecular mass:
    62892 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH42952.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH57763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI32711.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03585.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW74965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW74966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL35 Gene


neXtProt entry for KLHL35 Gene

Proteomics data for KLHL35 Gene at MOPED

Post-translational modifications for KLHL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL35 Gene

Domains & Families for KLHL35 Gene

Gene Families for KLHL35 Gene

Protein Domains for KLHL35 Gene

Suggested Antigen Peptide Sequences for KLHL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL35: view

Function for KLHL35 Gene

genes like me logo Genes that share phenotypes with KLHL35: view

Animal Model Products

miRNA for KLHL35 Gene

miRTarBase miRNAs that target KLHL35

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL35 Gene

Localization for KLHL35 Gene

Subcellular locations from

Jensen Localization Image for KLHL35 Gene COMPARTMENTS Subcellular localization image for KLHL35 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL35 Gene

Pathways & Interactions for KLHL35 Gene

SuperPathways for KLHL35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL35 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHL35 Gene

Drugs & Compounds for KLHL35 Gene

No Compound Related Data Available

Transcripts for KLHL35 Gene

Unigene Clusters for KLHL35 Gene

Kelch-like family member 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -

Relevant External Links for KLHL35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL35 Gene

mRNA expression in normal human tissues for KLHL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL35 Gene

This gene is overexpressed in Testis (x5.1), Brain - Nucleus accumbens (basal ganglia) (x4.9), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for KLHL35 Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL35 Gene

SOURCE GeneReport for Unigene cluster for KLHL35 Gene Hs.292451

genes like me logo Genes that share expression patterns with KLHL35: view

Protein tissue co-expression partners for KLHL35 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLHL35 Gene

Orthologs for KLHL35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL35 35
  • 87.7 (n)
  • 90 (a)
KLHL35 36
  • 90 (a)
(Canis familiaris)
Mammalia KLHL35 35
  • 89.71 (n)
  • 89.31 (a)
KLHL35 36
  • 89 (a)
(Mus musculus)
Mammalia Klhl35 35
  • 87.24 (n)
  • 90.48 (a)
Klhl35 16
Klhl35 36
  • 90 (a)
(Pan troglodytes)
Mammalia KLHL35 35
  • 99.54 (n)
  • 99.14 (a)
KLHL35 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Klhl35 35
  • 86.26 (n)
  • 88.17 (a)
(Monodelphis domestica)
Mammalia KLHL35 36
  • 63 (a)
(Gallus gallus)
Aves LOC769507 35
  • 63.84 (n)
  • 58.66 (a)
-- 36
  • 56 (a)
-- 36
  • 65 (a)
(Anolis carolinensis)
Reptilia KLHL35 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl35 35
  • 58.48 (n)
  • 53.82 (a)
(Danio rerio)
Actinopterygii LOC570873 35
  • 57.23 (n)
  • 47.01 (a)
klhl35 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for KLHL35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL35 Gene

Gene Tree for KLHL35 (if available)
Gene Tree for KLHL35 (if available)

Paralogs for KLHL35 Gene

(10) SIMAP similar genes for KLHL35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLHL35: view

Variants for KLHL35 Gene

Sequence variations from dbSNP and Humsavar for KLHL35 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs499745 -- 75,429,002(-) TTAAT(A/G)GCTTT intron-variant
rs542276 -- 75,430,913(+) TCAAA(C/T)AGGGT intron-variant, upstream-variant-2KB
rs572349 -- 75,431,834(+) GTGTT(G/T)CCCTA intron-variant, upstream-variant-2KB
rs532798 -- 75,431,178(+) gggag(A/G)gaggg intron-variant, upstream-variant-2KB
rs538451 -- 75,431,822(+) CGAGC(A/T)ACATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHL35 Gene

Variant ID Type Subtype PubMed ID
nsv897920 CNV Loss 21882294
dgv1224n71 CNV Loss 21882294
nsv897923 CNV Loss 21882294

Variation tolerance for KLHL35 Gene

Gene Damage Index Score: 2.03; 37.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL35 Gene

Disorders for KLHL35 Gene

Relevant External Links for KLHL35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL35 Gene

Publications for KLHL35 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3

Products for KLHL35 Gene

Sources for KLHL35 Gene

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