KLHL34 Gene
protein-coding GIFtS: 37
GCID: GC0XM021583
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Kelch-Like Family Member 34(Previous name: kelch-like 34 (Drosophila))
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Aliases
for KLHL34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Kelch-Like Family Member 341 2 | | Kelch-Like 34 (Drosophila)1 | | RP11-450P7.32 | | Kelch-Like 342 | | Kelch-Like Protein 342 |
Export aliases for KLHL34 gene to outside databasesPrevious GC identifer: GC0XM019415 |
Summaries
for KLHL34 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for KLHL34 Gene:
KLHL34 (kelch-like family member 34) is a protein-coding gene. An important paralog of this gene is KLHL42.
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Genomic Views
for KLHL34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000023.11 NC_018934.2 NT_167197.2
Regulatory elements:
 Regulatory transcription factor binding sites in the KLHL34 gene promoter:
HFH-3 AhR C/EBPbeta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 YY1 C/EBPalpha FOXI1 Msx-1
Other transcription factors
Search Chromatin IP Primers for KLHL34
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.12 Ensembl cytogenetic band: Xp22.12 HGNC cytogenetic band: Xp22.12KLHL34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM021583: view genomic region
(about GC identifiers)
Start:
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21,673,609 bp from pter |
End:
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21,676,448 bp from pter |
Size:
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2,840 bases |
Orientation:
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minus strand |
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Proteins
for KLHL34 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239 (See
protein sequence)Recommended Name: Kelch-like protein 34 Size: 644 amino acids; 70612 DaExplore the universe of human proteins at neXtProt for KLHL34: NX_Q8N239
Explore proteomics data for KLHL34 at MOPED
Post-translational modifications:  Modification sites at neXtProt Modification sites at PhosphoSitePlus
See KLHL34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_695002.1
ENSEMBL proteins: ENSP00000368813
KLHL34 Human Recombinant
Protein Products:KLHL34 Antibody
Products:KLHL34 Assay Products: |
Domains /
Families
for KLHL34 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
BTBD: BTB/POZ domain containingKLHL: Kelch-like
Selected InterPro protein domains (see all 7):Graphical View of Domain Structure for InterPro Entry Q8N239ProtoNet protein and cluster: Q8N239 2 Blocks protein domains: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats
KLHL34 for domains About GeneDecksing
|
Function
for KLHL34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Gene Ontology (GO): 1 molecular function term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005515 | protein binding |
-- | -- |
KLHL34 for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for KLHL34
| | | Predesigned siRNA for gene silencing in human, mouse, rat KLHL34 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for KLHL34 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL34  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34 |
Localization
for KLHL34 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
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| mitochondrion | 2 | | cytosol | 1 | | extracellular | 1 | | nucleus | 1 |
Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IDA | -- |
KLHL34 for ontologies About GeneDecksing
|
Pathways & Interactions
for KLHL34 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL34
Interactions:
Search GeneGlobe Interaction Network for KLHL34
|
Drugs & Compounds
for KLHL34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for KLHL34 (KLH34)
|
Transcripts
for KLHL34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for KLHL34 gene: NM_153270.1 Unigene Cluster for KLHL34: Kelch-like family member 34 Hs.448572 [show with all ESTs]Unigene Representative Sequence: AK0922791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000379499(uc004czz.1)
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for KLHL34
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat KLHL34 |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for KLHL34
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL34 | | | QuantiTect SYBR Green Assays in human, mouse, rat KLHL34 | | | QuantiFast Probe-based Assays in human, mouse, rat KLHL34 |
Additional mRNA sequence: AK092279.1 BC109031.2 1 DOTS entry: DT.427299 10 AceView cDNA sequences: NM_153270 BX091412 F23243 AA744969 AX747450 AK092279 AI792308 AI792176 AI004659 AI733575
GeneLoc Exon Structure
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Expression
for KLHL34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
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KLHL34 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAGTGCTGC
About this image KLHL34 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.448572
Custom PCR Arrays for KLHL34
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for KLHL34
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL34 | | | QuantiTect SYBR Green Assays in human, mouse, rat KLHL34 | | | QuantiFast Probe-based Assays in human, mouse, rat KLHL34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34 |
Orthologs
for KLHL34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of animals.
Orthologs for KLHL34 gene from Selected species (see all 12) About this table
ENSEMBL Gene Tree for KLHL34 (if available)
TreeFam Gene Tree for KLHL34 (if available) |
Paralogs
for KLHL34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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TryGeneCards Plus | Paralogs for KLHL34 gene
- KLHL422 KLHL132 KLHL222 KLHL262 KLHL312 KBTBD132 KBTBD112 KLHL322
- KLHL92 KLHL142 KLHL152 KLHL362 KLHDC7B2 KLHL332 KLHDC7A2
KLHL34 for paralogs About GeneDecksing
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Genomic Variants
for KLHL34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL34 (21673609 - 21676448 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for KLHL34: --
Human Gene Mutation Database (HGMD): KLHL34
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing KLHL34 |
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Disorders
/ Diseases
for KLHL34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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KLHL34 for disorders About GeneDecksing
Export disorders for KLHL34 gene to outside databases
|
Publications
for KLHL34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for KLHL34 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KLHL34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
- Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
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External Searches for KLHL34 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing KLHL34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing KLHL34 gene
(According to HUGE)
About This Section
TryGeneCards Plus | -- |
Specialized Databases showing KLHL34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for KLHL34 | Pharmacogenomics, SNPs, Pathways |
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TryGeneCards Plus | Patent Information for KLHL34 gene:
Search GeneIP for patents involving KLHL34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KLHL34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | Block miRNA regulation of human, mouse, rat KLHL34 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing KLHL34 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL34 | | Predesigned siRNA for gene silencing in human, mouse, rat KLHL34 | | | QuantiFast Probe-based Assays in human, mouse, rat KLHL34 | | QuantiTect SYBR Green Assays in human, mouse, rat KLHL34 | | | Custom PCR Arrays for KLHL34 | | Search Chromatin IP Primers for KLHL34 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL34 | | Search GeneGlobe Interaction Network for KLHL34 | | | Regulatory tfbs in KLHL34 promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for KLHL34 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL34 |
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