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KLHL34 Gene(Protein Coding)

Kelch Like Family Member 34

GCID:
GC0XM021583
GIFtS:
41
Genes Participants
UDN Logo

Aliases for KLHL34 Gene

Aliases for KLHL34 Gene

  • Kelch Like Family Member 34 2 3 5
  • Kelch-Like Family Member 34 3
  • Kelch-Like 34 (Drosophila) 2
  • Kelch-Like 34 3
  • RP11-450P7.3 3

External Ids for KLHL34 Gene

Previous GeneCards Identifiers for KLHL34 Gene

  • GC0XM019415

Summaries for KLHL34 Gene

GeneCards Summary for KLHL34 Gene

KLHL34 (Kelch Like Family Member 34) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL34 Gene

Genomics for KLHL34 Gene

Products:

  1. Regulatory Element

Regulatory Elements for KLHL34 Gene

Enhancers for KLHL34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL34 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL34 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KLHL34 gene promoter:

Genomic Location for KLHL34 Gene

Chromosome:
X
Start:
21,654,690 bp from pter
End:
21,658,387 bp from pter
Size:
3,698 bases
Orientation:
Minus strand

Genomic View for KLHL34 Gene

Genes around KLHL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL34 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KLHL34 Gene

Proteins for KLHL34 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KLHL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N239-KLH34_HUMAN
    Recommended name:
    Kelch-like protein 34
    Protein Accession:
    Q8N239

    Protein attributes for KLHL34 Gene

    Size:
    644 amino acids
    Molecular mass:
    70612 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL34 Gene

Proteomics data for KLHL34 Gene at MOPED

Protein Expression for KLHL34 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KLHL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL34 Gene

Domains & Families for KLHL34 Gene

Gene Families for KLHL34 Gene

HGNC:

Protein Domains for KLHL34 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KLHL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N239

UniProtKB/Swiss-Prot:

KLH34_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL34: view

Function for KLHL34 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for KLHL34 Gene

GenomeRNAi human phenotypes for KLHL34:
genes like me logo Genes that share phenotypes with KLHL34: view

Animal Model Products

miRNA for KLHL34 Gene

miRTarBase miRNAs that target KLHL34

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL34 Gene

Localization for KLHL34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL34 Gene COMPARTMENTS Subcellular localization image for KLHL34 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL34 Gene

Pathways & Interactions for KLHL34 Gene

SuperPathways for KLHL34 Gene

PathCards logoMore details on SuperPathways for KLHL34
No Data Available

Interacting Proteins for KLHL34 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368813%0d%0a9606.ENSP00000393596%0d%0a9606.ENSP00000335153%0d%0a9606.ENSP00000216455%0d%0a9606.ENSP00000271308%0d%0a9606.ENSP00000296509%0d%0a
Selected Interacting proteins: ENSP00000368813 for KLHL34 Gene via STRING

Gene Ontology (GO) - Biological Process for KLHL34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KLHL34 Gene

Drugs & Compounds for KLHL34 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for KLHL34 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for KLHL34 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL34 Gene

Kelch-like family member 34:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL34 Gene

No ASD Table

Relevant External Links for KLHL34 Gene

GeneLoc Exon Structure for
KLHL34
ECgene alternative splicing isoforms for
KLHL34

Expression for KLHL34 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for KLHL34 Gene

mRNA expression in normal human tissues for KLHL34 Gene
mRNA expression by BioGPS for KLHL34 GenemRNA expression by GTEx for KLHL34 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL34 Gene

This gene is overexpressed in Muscle - Skeletal (x23.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for KLHL34 Gene

This gene is overexpressed in Placenta (10.2), Testis (7.5), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL34 Gene



SOURCE GeneReport for Unigene cluster for KLHL34 Gene Hs.448572

genes like me logo Genes that share expression patterns with KLHL34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLHL34 Gene

Orthologs for KLHL34 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL34 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia KLHL34 35
  • 87.06 (n)
  • 89.75 (a)
KLHL34 36
  • 89 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia KLHL34 35
  • 86.43 (n)
  • 88.36 (a)
KLHL34 36
  • 88 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Klhl34 35
  • 79.68 (n)
  • 81.96 (a)
Klhl34 16
Klhl34 36
  • 82 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia KLHL34 35
  • 98.94 (n)
  • 98.66 (a)
KLHL34 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Klhl34 35
  • 78.9 (n)
  • 83.05 (a)
oppossum
(Monodelphis domestica)
 Mammalia KLHL34 36
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KLHL34 35
  • 59.06 (n)
  • 57.12 (a)
KLHL34 36
  • 56 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia KLHL34 36
  • 53 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia klhl34 35
  • 53.5 (n)
  • 51.09 (a)
zebrafish
(Danio rerio)
 Actinopterygii LOC561692 35
  • 50 (n)
  • 42.04 (a)
KLHL34 36
  • 41 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG1812 36
  • 24 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 23 (a)
 OneToMany
-- 36
  • 25 (a)
 OneToMany
CSA.8418 36
  • 22 (a)
 OneToMany
Species with no ortholog for KLHL34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL34 Gene

ENSEMBL:
Gene Tree for KLHL34 (if available)
TreeFam:
Gene Tree for KLHL34 (if available)

Paralogs for KLHL34 Gene

Paralogs for KLHL34 Gene

genes like me logo Genes that share paralogs with KLHL34: view

Variants for KLHL34 Gene

Sequence variations from dbSNP and Humsavar for KLHL34 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747750810 -- 21,656,352(+) CCCCC(C/T)GAGAT reference, synonymous-codon
rs747754470 -- 21,657,561(+) GCTGC(C/T)GATGG reference, synonymous-codon
rs747804174 -- 21,656,195(+) CCCCA(C/G)AAAAG reference, missense
rs747946059 -- 21,656,742(+) TGCGT(A/C/G)AGGCT reference, synonymous-codon
rs747995065 -- 21,659,891(+) CTTAA(A/T)CTCCA upstream-variant-2KB

Variation tolerance for KLHL34 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KLHL34 Gene

Disorders for KLHL34 Gene

Relevant External Links for KLHL34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL34

No disorders were found for KLHL34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL34 Gene

Publications for KLHL34 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for KLHL34 Gene

Sources for KLHL34 Gene

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