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KLHL34 Gene(Protein Coding)

Kelch Like Family Member 34

GCID:
GC0XM021583
GIFtS:
36
Genes Participants
UDN Logo

Aliases for KLHL34 Gene

Aliases for KLHL34 Gene

  • Kelch Like Family Member 34 2 3 5
  • Kelch-Like 34 (Drosophila) 2
  • Kelch-Like Protein 34 3
  • Kelch-Like 34 3
  • RP11-450P7.3 3

External Ids for KLHL34 Gene

Previous GeneCards Identifiers for KLHL34 Gene

  • GC0XM019415

Summaries for KLHL34 Gene

GeneCards Summary for KLHL34 Gene

KLHL34 (Kelch Like Family Member 34) is a Protein Coding gene. An important paralog of this gene is KLHL13.

Additional gene information for KLHL34 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL34 Gene

Genomics for KLHL34 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for KLHL34 Gene

Promoters and enhancers for KLHL34 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XI021658 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 -0.4 -405 1.2 ZBTB21 ZNF529 ZNF140 ZNF266 ZNF697 ZNF121 ZNF213 RBAK ZNF433 EZH2 KLHL34 YY2 SMPX
GH0XI021740 Enhancer 0.9 ENCODE 0.2 -82.9 -82942 1.5 FOXA2 INSM2 FEZF1 RARA ZNF121 SCRT2 ZNF680 RXRA TSHZ1 REST YY2 SMPX KLHL34 GC0XM021715
GH0XI021738 Enhancer 0.8 ENCODE 0.2 -80.3 -80331 0.2 PKNOX1 ZBTB21 KLF17 FEZF1 ZIC2 ZNF2 HIC1 ZNF335 CTBP1 ZNF366 SMPX KLHL34 GC0XM021715
GH0XI021756 Promoter/Enhancer 0.8 EPDnew ENCODE 0.2 -99.2 -99205 2.2 CTCF SMPX YY2 KLHL34 GC0XM021715
GH0XI021742 Enhancer 0.7 ENCODE 0.2 -84.1 -84071 0.2 ZBTB21 INSM2 ZNF366 GLI2 PRDM10 KLF8 ZNF639 RXRA HLF ATF2 SMPX KLHL34 GC0XM021715
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHL34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL34 gene promoter:

Genomic Locations for KLHL34 Gene

Genomic Locations for KLHL34 Gene
chrX:21,654,690-21,658,387
(GRCh38/hg38)
Size:
3,698 bases
Orientation:
Minus strand
chrX:21,673,609-21,676,448
(GRCh37/hg19)

Genomic View for KLHL34 Gene

Genes around KLHL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL34 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KLHL34 Gene

Proteins for KLHL34 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KLHL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N239-KLH34_HUMAN
    Recommended name:
    Kelch-like protein 34
    Protein Accession:
    Q8N239

    Protein attributes for KLHL34 Gene

    Size:
    644 amino acids
    Molecular mass:
    70612 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL34 Gene

Protein Expression for KLHL34 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KLHL34 Gene

No Post-translational modifications

Other Protein References for KLHL34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL34 Gene

Domains & Families for KLHL34 Gene

Gene Families for KLHL34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHL34 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KLHL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL34: view

No data available for UniProtKB/Swiss-Prot for KLHL34 Gene

Function for KLHL34 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL34: view

Phenotypes for KLHL34 Gene

GenomeRNAi human phenotypes for KLHL34:
genes like me logo Genes that share phenotypes with KLHL34: view

miRNA for KLHL34 Gene

miRTarBase miRNAs that target KLHL34

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL34 Gene

Localization for KLHL34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL34 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,HDA 22664934
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KLHL34 Gene

Pathways & Interactions for KLHL34 Gene

SuperPathways for KLHL34 Gene

PathCards logo More details on SuperPathways for KLHL34
No Data Available

Gene Ontology (GO) - Biological Process for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL34: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL34 Gene

Drugs & Compounds for KLHL34 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for KLHL34 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KLHL34 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL34 Gene

Kelch-like family member 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL34 Gene

No ASD Table

Relevant External Links for KLHL34 Gene

GeneLoc Exon Structure for
KLHL34
ECgene alternative splicing isoforms for
KLHL34

Expression for KLHL34 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL34 Gene

mRNA expression in normal human tissues for KLHL34 Gene
mRNA expression by BioGPS for KLHL34 GenemRNA expression by GTEx for KLHL34 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL34 Gene

This gene is overexpressed in Muscle - Skeletal (x23.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for KLHL34 Gene

This gene is overexpressed in Placenta (10.2), Testis (7.5), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL34 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLHL34 Gene:

KLHL34

SOURCE GeneReport for Unigene cluster for KLHL34 Gene:

Hs.448572
genes like me logo Genes that share expression patterns with KLHL34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL34 Gene

Orthologs for KLHL34 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KLHL34 33 34
  • 98.94 (n)
cow
(Bos Taurus)
 Mammalia KLHL34 33 34
  • 87.06 (n)
dog
(Canis familiaris)
 Mammalia KLHL34 33 34
  • 86.43 (n)
mouse
(Mus musculus)
 Mammalia Klhl34 33 16 34
  • 79.68 (n)
rat
(Rattus norvegicus)
 Mammalia Klhl34 33
  • 78.9 (n)
oppossum
(Monodelphis domestica)
 Mammalia KLHL34 34
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KLHL34 33 34
  • 59.06 (n)
lizard
(Anolis carolinensis)
 Reptilia KLHL34 34
  • 53 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia klhl34 33
  • 53.5 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC561692 33
  • 50 (n)
KLHL34 34
  • 41 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG1812 34
  • 24 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 25 (a)
 OneToMany
-- 34
  • 23 (a)
 OneToMany
CSA.8418 34
  • 22 (a)
 OneToMany
Species where no ortholog for KLHL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL34 Gene

ENSEMBL:
Gene Tree for KLHL34 (if available)
TreeFam:
Gene Tree for KLHL34 (if available)

Paralogs for KLHL34 Gene

Paralogs for KLHL34 Gene

genes like me logo Genes that share paralogs with KLHL34: view

Variants for KLHL34 Gene

Sequence variations from dbSNP and Humsavar for KLHL34 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001765910 -- 21,660,251(-) G/C/T upstream_transcript_variant
rs1002683955 -- 21,659,701(-) G/A upstream_transcript_variant
rs1003304266 -- 21,657,477(-) C/T coding_sequence_variant, synonymous_variant
rs1003657552 -- 21,658,396(-) A/C upstream_transcript_variant
rs1004977735 -- 21,660,250(-) G/C upstream_transcript_variant

Variation tolerance for KLHL34 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLHL34 Gene

Disorders for KLHL34 Gene

Additional Disease Information for KLHL34

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLHL34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL34 Gene

Publications for KLHL34 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa BS … Friedman JS (Human genomics 2013) 3 58

Products for KLHL34 Gene

Sources for KLHL34 Gene

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