Aliases for KLHL34 Gene
Aliases for KLHL34 Gene
External Ids for KLHL34 Gene
- HGNC: 26634
- Entrez Gene: 257240
- Ensembl: ENSG00000185915
- UniProtKB: Q8N239
Previous GeneCards Identifiers for KLHL34 Gene
- GC0XM019415
Summaries for KLHL34 Gene
GeneCards Summary for KLHL34 Gene
KLHL34 (Kelch Like Family Member 34) is a Protein Coding gene. An important paralog of this gene is KLHL13.
Additional gene information for KLHL34 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL34 Gene
Genomics for KLHL34 Gene
GeneHancer (GH) Regulatory Elements for KLHL34 Gene
Promoters and enhancers for KLHL34 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XI021658 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 550.8 | -0.4 | -405 | 1.2 | ZBTB21 ZNF529 ZNF140 ZNF266 ZNF697 ZNF121 ZNF213 RBAK ZNF433 EZH2 | KLHL34 YY2 SMPX | |
GH0XI021740 | Enhancer | 0.9 | ENCODE | 0.2 | -82.9 | -82942 | 1.5 | FOXA2 INSM2 FEZF1 RARA ZNF121 SCRT2 ZNF680 RXRA TSHZ1 REST | YY2 SMPX KLHL34 GC0XM021715 | |
GH0XI021738 | Enhancer | 0.8 | ENCODE | 0.2 | -80.3 | -80331 | 0.2 | PKNOX1 ZBTB21 KLF17 FEZF1 ZIC2 ZNF2 HIC1 ZNF335 CTBP1 ZNF366 | SMPX KLHL34 GC0XM021715 | |
GH0XI021756 | Promoter/Enhancer | 0.8 | EPDnew ENCODE | 0.2 | -99.2 | -99205 | 2.2 | CTCF | SMPX YY2 KLHL34 GC0XM021715 | |
GH0XI021742 | Enhancer | 0.7 | ENCODE | 0.2 | -84.1 | -84071 | 0.2 | ZBTB21 INSM2 ZNF366 GLI2 PRDM10 KLF8 ZNF639 RXRA HLF ATF2 | SMPX KLHL34 GC0XM021715 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KLHL34 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KLHL34 gene promoter:
Regulatory Element Products
Genomic Locations for KLHL34 Gene
Genomic Locations for KLHL34 Gene
- chrX:21,654,690-21,658,387
- (GRCh38/hg38)
- Size:
- 3,698 bases
- Orientation:
- Minus strand
- chrX:21,673,609-21,676,448
- (GRCh37/hg19)
Genomic View for KLHL34 Gene
Genes around KLHL34 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.12 by Ensembl
- Xp22.12 by Entrez Gene
- Xp22.12 by HGNC
KLHL34 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for KLHL34 Gene
Proteins for KLHL34 Gene
-
Protein details for KLHL34 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N239-KLH34_HUMAN
- Recommended name:
- Kelch-like protein 34
- Protein Accession:
- Q8N239
Protein attributes for KLHL34 Gene
- Size:
- 644 amino acids
- Molecular mass:
- 70612 Da
- Quaternary structure:
- No Data Available
Protein Expression for KLHL34 Gene
Post-translational modifications for KLHL34 Gene
No Post-translational modifications
Other Protein References for KLHL34 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KLHL34
- Invitrogen Antibodies for KLHL34
- GeneTex KLHL34 antibody for KLHL34
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KLHL34
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- Search GeneTex for Proteins for KLHL34
Assay Products
No data available for DME Specific Peptides for KLHL34 Gene
Domains & Families for KLHL34 Gene
Gene Families for KLHL34 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KLHL34 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLHL34 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for KLHL34 Gene
Function for KLHL34 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | contributes_to ubiquitin-protein transferase activity | IBA | -- |
Phenotypes for KLHL34 Gene
- GenomeRNAi human phenotypes for KLHL34:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for KLHL34 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KLHL34 gene
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CRISPR Products
-
OriGene CRISPR knockouts for KLHL34
- genomics-online: gRNA clones - Search results for 56 available KLHL34 gene related products
- Overview of 56 available KLHL34 gene related products
- Applied Biological Materials CRISPR for KLHL34
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLHL34
- GenScript: Design CRISPR guide RNA sequences for KLHL34
miRNA for KLHL34 Gene
- miRTarBase miRNAs that target KLHL34
miRNA Products
- Search ViGene Biosciences for KLHL34
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KLHL34
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- genomics-online: shRNA clones - Search results for 56 available KLHL34 gene related products
- Overview of 56 available KLHL34 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLHL34 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for KLHL34
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KLHL34
-
ViGene Biosciences adenoviral particle packaged cDNA for KLHL34 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KLHL34 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KLHL34 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL34 Gene
Localization for KLHL34 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA,HDA | 22664934 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KLHL34 Gene
Pathways & Interactions for KLHL34 Gene
No Data Available
Interacting Proteins for KLHL34 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for KLHL34 Gene
Transcripts for KLHL34 Gene
mRNA/cDNA for KLHL34 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KLHL34 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KLHL34
- genomics-online: gRNA clones - Search results for 56 available KLHL34 gene related products
- Overview of 56 available KLHL34 gene related products
- Applied Biological Materials CRISPR for KLHL34
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLHL34
- GenScript: Design CRISPR guide RNA sequences for KLHL34
miRNA Products
- Search ViGene Biosciences for KLHL34
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KLHL34
- Browse OriGene Inhibitory RNA Products For KLHL34
- genomics-online: shRNA clones - Search results for 56 available KLHL34 gene related products
- Overview of 56 available KLHL34 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLHL34 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for KLHL34
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KLHL34 Gene
mRNA differential expression in normal tissues according to GTEx for KLHL34 Gene
This gene is overexpressed in Muscle - Skeletal (x23.8) and Heart - Left Ventricle (x4.5).
This gene is overexpressed in Placenta (10.2), Testis (7.5), and Heart (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL34 Gene
NURSA nuclear receptor signaling pathways regulating expression of KLHL34 Gene:
KLHL34SOURCE GeneReport for Unigene cluster for KLHL34 Gene:
Hs.448572Primer Products
-
OriGene qPCR primer pairs for KLHL34
- genomics-online: primer clones - Search results for 56 available KLHL34 gene related products
- Overview of 56 available KLHL34 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL34 Gene
Orthologs for KLHL34 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | KLHL34 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | KLHL34 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | KLHL34 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Klhl34 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Klhl34 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | KLHL34 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | KLHL34 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | KLHL34 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | klhl34 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC561692 33 |
|
||
KLHL34 34 |
|
OneToOne | |||
fruit fly (Drosophila melanogaster) |
Insecta | CG1812 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
CSA.8418 34 |
|
OneToMany |
- Species where no ortholog for KLHL34 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KLHL34 Gene
Variants for KLHL34 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001765910 | -- | 21,660,251(-) | G/C/T | upstream_transcript_variant | |
rs1002683955 | -- | 21,659,701(-) | G/A | upstream_transcript_variant | |
rs1003304266 | -- | 21,657,477(-) | C/T | coding_sequence_variant, synonymous_variant | |
rs1003657552 | -- | 21,658,396(-) | A/C | upstream_transcript_variant | |
rs1004977735 | -- | 21,660,250(-) | G/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.55;
29.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLHL34 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KLHL34
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLHL34 Gene
Disorders for KLHL34 Gene
Additional Disease Information for KLHL34
No disorders were found for KLHL34 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL34 Gene
Publications for KLHL34 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa BS … Friedman JS (Human genomics 2013) 3 58
Products for KLHL34 Gene
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- Invitrogen Antibodies for KLHL34
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- antibodies-online: Search results for available KLHL34 related products ranked by validation data
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- GeneTex KLHL34 antibody for KLHL34
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- ViGene Biosciences adenoviral particle packaged cDNA for KLHL34 gene
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- Overview of 56 available KLHL34 gene related products
- genomics-online: primer clones - Search results for 56 available KLHL34 gene related products
- Overview of 56 available KLHL34 gene related products
- genomics-online: shRNA clones - Search results for 56 available KLHL34 gene related products
- Overview of 56 available KLHL34 gene related products
Sources for KLHL34 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew