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KLHL34 Gene

protein-coding GIFtS: 37
GCID: GC0XM021583

Kelch-Like Family Member 34

(Previous name: kelch-like 34 (Drosophila))

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Kelch-Like Family Member 34¹ ²
Kelch-Like 34 (Drosophila)¹
RP11-450P7.3²
Kelch-Like 34²
Kelch-Like Protein 34²

External Ids:	HGNC: 26634¹	Entrez Gene: 257240²	Ensembl: ENSG00000185915⁷	UniProtKB: Q8N239³

Export aliases for KLHL34 gene to outside databases

Previous GC identifer: GC0XM019415

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL34 Gene:

KLHL34 (kelch-like family member 34) is a protein-coding gene. An important paralog of this gene is KLHL42.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000023.10 NC_018934.2 NT_167197.2

Regulatory elements:

Regulatory transcription factor binding sites in the KLHL34 gene promoter:
HFH-3 AhR C/EBPbeta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 YY1 C/EBPalpha FOXI1 Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLHL34 promoter sequence

Search Chromatin IP Primers for KLHL34

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL34

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.12 Ensembl cytogenetic band: Xp22.12 HGNC cytogenetic band: Xp22.12

KLHL34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL34 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM021583: view genomic region (about GC identifiers)

Start:	21,673,609 bp from pter	End:	21,676,448 bp from pter
Size:	2,840 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239 (See protein sequence)

Recommended Name: Kelch-like protein 34

Size: 644 amino acids; 70612 Da

Explore the universe of human proteins at neXtProt for KLHL34: NX_Q8N239

Explore proteomics data for KLHL34 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See KLHL34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_695002.1

ENSEMBL proteins:

ENSP00000368813

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

BTBD: BTB/POZ domain containing

KLHL: Kelch-like

Selected InterPro protein domains (see all 7):

IPR006652 Kelch_1

IPR011333 BTB/POZ_fold

IPR017096 Kelch-like_gigaxonin-typ

IPR013069 BTB_POZ

IPR011705 BACK

Graphical View of Domain Structure for InterPro Entry Q8N239

ProtoNet protein and cluster: Q8N239

2 Blocks protein domains:

IPB000210 BTB/POZ domain

IPB011705 BTB/Kelch-associated

UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239

Similarity: Contains 1 BACK (BTB/Kelch associated) domain

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 6 Kelch repeats

Find genes that share domains with KLHL34 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

Find genes that share ontologies with KLHL34 About GenesLikeMe

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	2
cytosol	1
extracellular	1
nucleus	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	--

Find genes that share ontologies with KLHL34 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for KLHL34 gene:

NM_153270.1

Unigene Cluster for KLHL34:

Kelch-like family member 34

Hs.448572 [show with all ESTs]

Unigene Representative Sequence: AK092279

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000379499(uc004czz.1)

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Additional mRNA sequence:

AK092279.1 BC109031.2

1 DOTS entry:

DT.427299

10 AceView cDNA sequences:

NM_153270 BX091412 F23243 AA744969 AX747450 AK092279 AI792308 AI792176

AI004659 AI733575

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLHL34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAGTGCTGC

About this image

KLHL34 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

KLHL34 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.448572

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KLHL34 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Klhl34^{1 , 5}	kelch-like 34 (Drosophila)⁵ kelch-like 34¹	79.68(n)¹ 81.96(a)¹		X (72.76 cM)⁵ 245683¹ NM_001081667.2¹ NP_001075136.1¹ 157818435⁵
chicken (Gallus gallus)	Aves	KLHL34¹	kelch-like 34 (Drosophila)	59.06(n) 57.12(a)		418604 XM_004934669.1 XP_004934726.1
lizard (Anolis carolinensis)	Reptilia	KLHL34⁶	kelch-like family member 34	53(a)	1 ↔ 1	3(124498741-124500489)
tropical clawed frog (Xenopus tropicalis)	Amphibia	klhl34¹	kelch-like family member 34	53.5(n) 51.09(a)		100496316 XM_002936045.2 XP_002936091.1
zebrafish (Danio rerio)	Actinopterygii	LOC561692¹	kelch-like protein 34-like	50(n) 42.04(a)		561692 XM_005162771.1 XP_005162828.1
fruit fly (Drosophila melanogaster)	Insecta	CG1812⁶	--	24(a)	1 → many	X(20382574-20386859)

ENSEMBL Gene Tree for KLHL34 (if available)
TreeFam Gene Tree for KLHL34 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for KLHL34 gene

KLHL42² KLHL13² KLHL22² KLHL26² KLHL31² KBTBD13² KBTBD11² KLHL32²

KLHL9² KLHL14² KLHL15² KLHL36² KLHDC7B² KLHL33² KLHDC7A²

Find genes that share paralogs with KLHL34 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201440389^1,2		--	21673332(+)	`AGATT-/AAAAAA`	1	--	ds500¹		0	--	--	--	--
rs199902733^1,2		--	21673352(+)	`AGAGA-/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs5904488^1,2	C,H	--	21673467(+)	`TTAACC/AAAGGC`	1	--	ds500¹		5		NS EA NA	420
rs184295815^1,2		--	21673655(+)	`TAACTA/GTAAGA`	1	--	ut3¹		0	--	--	--	--
rs149462416^1,2		--	21673783(+)	`CCCCGA/CCCCGC`	1	--	ut3¹		0	--	--	--	--
rs12861104^1,2	H	--	21673859(+)	`CTTCAG/AAAGCC`	1	--	ut3¹ ese³		4		NS EA	404
rs12861135^1,2	C,H	--	21673877(+)	`TCCCAG/AAATCC`	1	--	ut3¹ ese³		2		NS NA	182
rs142552568^1,2	F	--	21674020(+)	`CTCTCG/ATCGTC`	2	/D	syn¹		1		NA	4410
rs146464429^1,2	C,F	--	21674057(+)	`CGCACC/GGCAGG`	2	P R	mis¹		1		NA	4362
rs4451438^1,2	C	--	21674077(+)	`GCCCAG/TGGCAA`	2	P	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KLHL34 (21673609 - 21676448 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for KLHL34: --
Human Gene Mutation Database (HGMD): KLHL34

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Find genes that share disorders with KLHL34 About GenesLikeMe

Export disorders for KLHL34 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KLHL34 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KLHL34)

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)¹ Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)¹ Taipale M....Lindquist S. (Cell 2012)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 257240	HGNC: 26634	AceView: FLJ34960	Ensembl:ENSG00000185915	euGenes: HUgn257240
ECgene: KLHL34	H-InvDB: KLHL34

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KLHL34	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KLHL34 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KLHL34 gene:
Search GeneIP for patents involving KLHL34

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34

	SwitchGear 3'UTR luciferase reporter plasmids for KLHL34
	SwitchGear Promoter luciferase reporter plasmids for KLHL34

Search ThermoFisher Antibodies for KLHL34

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL34

Browse compounds at ApexBio

Search Addgene for plasmids for KLHL34

	Search eBioscience for proteins for KLHL34
	Search eBioscience for elisas for KLHL34
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for KLHL34

	antibodies-online antibodies for KLHL34
	antibodies-online kits for KLHL34 (2 products)
	Search antibodies-online for peptides for KLHL34
	antibodies-online proteins for KLHL34

Search GeneTex for proteins for KLHL34

GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KLHL34 gene at Home site.

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KLHL34 Gene

Kelch-Like Family Member 34

Aliases
for KLHL34 gene

Summaries
for KLHL34 gene

Genomic Views
for KLHL34 gene

Proteins
for KLHL34 gene

KLHL34 Human Recombinant Protein Products:

KLHL34 Antibody Products:

KLHL34 Assay Products:

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for KLHL34 gene

Function
for KLHL34 gene

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for KLHL34 gene

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for KLHL34 gene

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for KLHL34 gene

Transcripts
for KLHL34 gene

Expression
for KLHL34 gene

Orthologs
for KLHL34 gene

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for KLHL34 gene

Genomic Variants
for KLHL34 gene

Disorders / Diseases
for KLHL34 gene

Publications
for KLHL34 gene

External Searches for KLHL34 gene

Genome Databases showing KLHL34 gene

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Specialized Databases showing KLHL34 gene

Intellectual Property
for KLHL34 gene

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for KLHL34 gene

View Random Gene

GeneCards Suite

Advanced Search

Export list of displayed genes

KLHL34 Gene

Kelch-Like Family Member 34

Aliasesfor KLHL34 gene

Summariesfor KLHL34 gene

Genomic Viewsfor KLHL34 gene

Proteinsfor KLHL34 gene

KLHL34 Human Recombinant Protein Products:

KLHL34 Antibody Products:

KLHL34 Assay Products:

Domains /Familiesfor KLHL34 gene

Functionfor KLHL34 gene

Localizationfor KLHL34 gene

Pathways & Interactionsfor KLHL34 gene

Drugs & Compoundsfor KLHL34 gene

Transcriptsfor KLHL34 gene

Expression for KLHL34 gene

Orthologsfor KLHL34 gene

Paralogsfor KLHL34 gene

Genomic Variantsfor KLHL34 gene

Disorders / Diseasesfor KLHL34 gene

Publicationsfor KLHL34 gene

External Searches for KLHL34 gene

Genome Databases showing KLHL34 gene

Other Databases showing KLHL34 gene

Specialized Databases showing KLHL34 gene

Intellectual Propertyfor KLHL34 gene

Productsfor KLHL34 gene

View Random Gene

Aliases
for KLHL34 gene

Summaries
for KLHL34 gene

Genomic Views
for KLHL34 gene

Proteins
for KLHL34 gene

Domains /
Families
for KLHL34 gene

Function
for KLHL34 gene

Localization
for KLHL34 gene

Pathways & Interactions
for KLHL34 gene

Drugs & Compounds
for KLHL34 gene

Transcripts
for KLHL34 gene

Expression
for KLHL34 gene

Orthologs
for KLHL34 gene

Paralogs
for KLHL34 gene

Genomic Variants
for KLHL34 gene

Disorders / Diseases
for KLHL34 gene

Publications
for KLHL34 gene

Intellectual Property
for KLHL34 gene

Products
for KLHL34 gene