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KLHL34 Gene

protein-coding   GIFtS: 37
GCID: GC0XM021583

Kelch-Like Family Member 34

(Previous name: kelch-like 34 (Drosophila))
  Search for KLHL34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 341 2
Kelch-Like 34 (Drosophila)1
RP11-450P7.32
Kelch-Like 342
Kelch-Like Protein 342

External Ids:    HGNC: 266341   Entrez Gene: 2572402   Ensembl: ENSG000001859157   UniProtKB: Q8N2393   

Export aliases for KLHL34 gene to outside databases

Previous GC identifer: GC0XM019415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL34 Gene:
KLHL34 (kelch-like family member 34) is a protein-coding gene. An important paralog of this gene is KLHL42.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL34 gene promoter:
         HFH-3   AhR   C/EBPbeta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   C/EBPalpha   FOXI1   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL34 promoter sequence
   Search Chromatin IP Primers for KLHL34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.12   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.12

KLHL34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL34 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM021583:  view genomic region     (about GC identifiers)

Start:
21,673,609 bp from pter      End:
21,676,448 bp from pter
Size:
2,840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239 (See protein sequence)
Recommended Name: Kelch-like protein 34  
Size: 644 amino acids; 70612 Da

Explore the universe of human proteins at neXtProt for KLHL34: NX_Q8N239

Explore proteomics data for KLHL34 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHL34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_695002.1  
    ENSEMBL proteins: 
     ENSP00000368813  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR013069 BTB_POZ
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q8N239

    ProtoNet protein and cluster: Q8N239

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with KLHL34           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHL34           About GenesLikeMe


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    1 qRT-PCR Assays for microRNA that regulate KLHL34:
    hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL34 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--

    Find genes that share ontologies with KLHL34           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL34
    Interactions:

        Search GeneGlobe Interaction Network for KLHL34

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL34 (KLH34)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLHL34 gene: 
    NM_153270.1  

    Unigene Cluster for KLHL34:

    Kelch-like family member 34
    Hs.448572  [show with all ESTs]
    Unigene Representative Sequence: AK092279
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379499(uc004czz.1)
    miRNA
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    hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL34 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KLHL34
      QuantiFast Probe-based Assays in human, mouse, rat KLHL34

    Additional mRNA sequence: 

    AK092279.1 BC109031.2 

    1 DOTS entry:

    DT.427299 

    10 AceView cDNA sequences:

    NM_153270 BX091412 F23243 AA744969 AX747450 AK092279 AI792308 AI792176 
    AI004659 AI733575 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGTGCTGC
    KLHL34 Expression
    About this image

    KLHL34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.448572
        Custom PCR Arrays for KLHL34
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLHL34 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl341 , 5 kelch-like 34 (Drosophila)5
    kelch-like 341
    79.68(n)1
    81.96(a)1
      X (72.76 cM)5
    2456831  NM_001081667.21  NP_001075136.11 
     1578184355 
    chicken
    (Gallus gallus)
    Aves KLHL341 kelch-like 34 (Drosophila) 59.06(n)
    57.12(a)
      418604  XM_004934669.1  XP_004934726.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL346
    kelch-like family member 34
    53(a)
    1 ↔ 1
    3(124498741-124500489)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhl341 kelch-like family member 34 53.5(n)
    51.09(a)
      100496316  XM_002936045.2  XP_002936091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5616921 kelch-like protein 34-like 50(n)
    42.04(a)
      561692  XM_005162771.1  XP_005162828.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18126
    --
    24(a)
    1 → many
    X(20382574-20386859)


    ENSEMBL Gene Tree for KLHL34 (if available)
    TreeFam Gene Tree for KLHL34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL34 gene
    KLHL422  KLHL132  KLHL222  KLHL262  KLHL312  KBTBD132  KBTBD112  KLHL322  
    KLHL92  KLHL142  KLHL152  KLHL362  KLHDC7B2  KLHL332  KLHDC7A2  

    Find genes that share paralogs with KLHL34           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL34 (see all 87)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2014403891,2
    --21673332(+) AGATT-/AAAAAA 1 -- ds50010--------
    rs1999027331,2
    --21673352(+) AGAGA-/TTTTTT 1 -- ds50010--------
    rs59044881,2
    C,H--21673467(+) TTAACC/AAAGGC 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 420
    rs1842958151,2
    --21673655(+) TAACTA/GTAAGA 1 -- ut310--------
    rs1494624161,2
    --21673783(+) CCCCGA/CCCCGC 1 -- ut310--------
    rs128611041,2
    H--21673859(+) CTTCAG/AAAGCC 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 404
    rs128611351,2
    C,H--21673877(+) TCCCAG/AAATCC 1 -- ut31 ese32Minor allele frequency- A:0.01NS NA 182
    rs1425525681,2
    F--21674020(+) CTCTCG/ATCGTC 2 /D syn11Minor allele frequency- A:0.00NA 4410
    rs1464644291,2
    C,F--21674057(+) CGCACC/GGCAGG 2 P R mis11Minor allele frequency- G:0.00NA 4362
    rs44514381,2
    C--21674077(+) GCCCAG/TGGCAA 2 P syn10--------

    HapMap Linkage Disequilibrium report for KLHL34 (21673609 - 21676448 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLHL34: --
    Human Gene Mutation Database (HGMD): KLHL34
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL34
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with KLHL34           About GenesLikeMe


    Export disorders for KLHL34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL34 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KLHL34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 257240 HGNC: 26634 AceView: FLJ34960 Ensembl:ENSG00000185915 euGenes: HUgn257240
    ECgene: KLHL34 H-InvDB: KLHL34

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL34 gene:
    Search GeneIP for patents involving KLHL34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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