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Aliases for KLHL34 Gene

Aliases for KLHL34 Gene

  • Kelch-Like Family Member 34 2 3
  • Kelch-Like 34 (Drosophila) 2
  • Kelch-Like Protein 34 3
  • Kelch-Like 34 3
  • RP11-450P7.3 3

External Ids for KLHL34 Gene

Summaries for KLHL34 Gene

GeneCards Summary for KLHL34 Gene

KLHL34 (Kelch-Like Family Member 34) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL34 Gene

Genomics for KLHL34 Gene

Genomic Location for KLHL34 Gene

Start:
21,654,690 bp from pter
End:
21,658,330 bp from pter
Size:
3,641 bases
Orientation:
Minus strand

Genomic View for KLHL34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL34 Gene

Regulatory Elements for KLHL34 Gene

Proteins for KLHL34 Gene

  • Protein details for KLHL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N239-KLH34_HUMAN
    Recommended name:
    Kelch-like protein 34
    Protein Accession:
    Q8N239
    Secondary Accessions:

    Protein attributes for KLHL34 Gene

    Size:
    644 amino acids
    Molecular mass:
    70612 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL34 Gene

Proteomics data for KLHL34 Gene at MOPED

Post-translational modifications for KLHL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL34 Gene

Domains for KLHL34 Gene

Gene Families for KLHL34 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

UniProtKB/Swiss-Prot:

KLH34_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q8N239
  • Contains 1 BTB (POZ) domain.:
    • Q8N239
Similarity:
  • Contains 6 Kelch repeats.:
    • Q8N239
genes like me logo Genes that share domains with KLHL34: view

Function for KLHL34 Gene

Gene Ontology (GO) - Molecular Function for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL34: view

miRNA for KLHL34 Gene

miRTarBase miRNAs that target KLHL34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL34 Gene

Localization for KLHL34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL34 Gene COMPARTMENTS Subcellular localization image for KLHL34 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with KLHL34: view

Pathways for KLHL34 Gene

SuperPathways for KLHL34 Gene

No Data Available

Interacting Proteins for KLHL34 Gene

Gene Ontology (GO) - Biological Process for KLHL34 Gene

None

No data available for Pathways by source for KLHL34 Gene

Transcripts for KLHL34 Gene

mRNA/cDNA for KLHL34 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL34 Gene

Kelch-like family member 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL34 Gene

No ASD Table

Relevant External Links for KLHL34 Gene

GeneLoc Exon Structure for
KLHL34
ECgene alternative splicing isoforms for
KLHL34

Expression for KLHL34 Gene

mRNA expression in normal human tissues for KLHL34 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL34 Gene

This gene is overexpressed in Muscle - Skeletal (23.8) and Heart - Left Ventricle (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLHL34 Gene

SOURCE GeneReport for Unigene cluster for KLHL34 Gene Hs.448572

genes like me logo Genes that share expressions with KLHL34: view

Orthologs for KLHL34 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL34 36
  • 98.94 (n)
  • 98.66 (a)
KLHL34 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL34 36
  • 87.06 (n)
  • 89.75 (a)
KLHL34 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL34 36
  • 86.43 (n)
  • 88.36 (a)
KLHL34 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl34 36
  • 79.68 (n)
  • 81.96 (a)
Klhl34 16
Klhl34 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL34 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl34 36
  • 78.9 (n)
  • 83.05 (a)
chicken
(Gallus gallus)
Aves KLHL34 36
  • 59.06 (n)
  • 57.12 (a)
KLHL34 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL34 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl34 36
  • 53.5 (n)
  • 51.09 (a)
zebrafish
(Danio rerio)
Actinopterygii KLHL34 37
  • 41 (a)
OneToOne
LOC561692 36
  • 50 (n)
  • 42.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1812 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
-- 37
  • 25 (a)
OneToMany
CSA.8418 37
  • 22 (a)
OneToMany
Species with no ortholog for KLHL34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL34 Gene

ENSEMBL:
Gene Tree for KLHL34 (if available)
TreeFam:
Gene Tree for KLHL34 (if available)

Paralogs for KLHL34 Gene

genes like me logo Genes that share paralogs with KLHL34: view

Variants for KLHL34 Gene

Sequence variations from dbSNP and Humsavar for KLHL34 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4451438 -- 21,655,959(+) GCCCA(G/T)GGCAA synonymous-codon, reference
rs5904488 -- 21,655,349(+) TTAAC(A/C)AAGGC downstream-variant-500B
rs5904576 -- 21,656,331(+) CCCTC(C/G)CCTCT reference, synonymous-codon
rs12861104 -- 21,655,741(+) CTTCA(A/G)AAGCC utr-variant-3-prime
rs12861135 -- 21,655,759(+) TCCCA(A/G)AATCC utr-variant-3-prime

Relevant External Links for KLHL34 Gene

HapMap Linkage Disequilibrium report
KLHL34

No data available for Structural Variations from Database of Genomic Variants (DGV) for KLHL34 Gene

Disorders for KLHL34 Gene

No disorders were found for KLHL34 Gene.

No data available for UniProtKB/Swiss-Prot for KLHL34 Gene

Publications for KLHL34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KLHL34 Gene

  • antibodies-online proteins for KLHL34
  • antibodies-online antibodies for KLHL34
  • antibodies-online kits for KLHL34

Sources for KLHL34 Gene

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