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Aliases for KLHL34 Gene

Aliases for KLHL34 Gene

  • Kelch-Like Family Member 34 2 3
  • Kelch-Like 34 (Drosophila) 2
  • Kelch-Like Protein 34 3
  • Kelch-Like 34 3
  • RP11-450P7.3 3

External Ids for KLHL34 Gene

Previous GeneCards Identifiers for KLHL34 Gene

  • GC0XM019415

Summaries for KLHL34 Gene

GeneCards Summary for KLHL34 Gene

KLHL34 (Kelch-Like Family Member 34) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL34 Gene

Genomics for KLHL34 Gene

Regulatory Elements for KLHL34 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL34 Gene

21,654,690 bp from pter
21,658,330 bp from pter
3,641 bases
Minus strand

Genomic View for KLHL34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL34 Gene

Proteins for KLHL34 Gene

  • Protein details for KLHL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 34
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KLHL34 Gene

    644 amino acids
    Molecular mass:
    70612 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL34 Gene

Proteomics data for KLHL34 Gene at MOPED

Post-translational modifications for KLHL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL34 Gene

Domains for KLHL34 Gene

Gene Families for KLHL34 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N239
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL34: view

Function for KLHL34 Gene

Gene Ontology (GO) - Molecular Function for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL34: view

Animal Model Products

miRNA for KLHL34 Gene

miRTarBase miRNAs that target KLHL34

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL34

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL34 Gene

Localization for KLHL34 Gene

Subcellular locations from

Jensen Localization Image for KLHL34 Gene COMPARTMENTS Subcellular localization image for KLHL34 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with KLHL34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL34 Gene

Pathways for KLHL34 Gene

SuperPathways for KLHL34 Gene

No Data Available

Interacting Proteins for KLHL34 Gene

Gene Ontology (GO) - Biological Process for KLHL34 Gene


No data available for Pathways by source for KLHL34 Gene

Transcripts for KLHL34 Gene

mRNA/cDNA for KLHL34 Gene

(10) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL34 Gene

Kelch-like family member 34:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL34

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL34 Gene

No ASD Table

Relevant External Links for KLHL34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL34 Gene

mRNA expression in normal human tissues for KLHL34 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL34 Gene

This gene is overexpressed in Muscle - Skeletal (23.8) and Heart - Left Ventricle (4.5).

Protein differential expression in normal tissues for KLHL34 Gene

This gene is overexpressed in Placenta (10.2), Testis (7.5), and Heart (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLHL34 Gene

SOURCE GeneReport for Unigene cluster for KLHL34 Gene Hs.448572

genes like me logo Genes that share expressions with KLHL34: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for KLHL34 Gene

Orthologs for KLHL34 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL34 35
  • 87.06 (n)
  • 89.75 (a)
KLHL34 36
  • 89 (a)
(Canis familiaris)
Mammalia KLHL34 35
  • 86.43 (n)
  • 88.36 (a)
KLHL34 36
  • 88 (a)
(Mus musculus)
Mammalia Klhl34 35
  • 79.68 (n)
  • 81.96 (a)
Klhl34 16
Klhl34 36
  • 82 (a)
(Pan troglodytes)
Mammalia KLHL34 35
  • 98.94 (n)
  • 98.66 (a)
KLHL34 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Klhl34 35
  • 78.9 (n)
  • 83.05 (a)
(Monodelphis domestica)
Mammalia KLHL34 36
  • 71 (a)
(Gallus gallus)
Aves KLHL34 35
  • 59.06 (n)
  • 57.12 (a)
KLHL34 36
  • 56 (a)
(Anolis carolinensis)
Reptilia KLHL34 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl34 35
  • 53.5 (n)
  • 51.09 (a)
(Danio rerio)
Actinopterygii LOC561692 35
  • 50 (n)
  • 42.04 (a)
KLHL34 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1812 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
-- 36
  • 25 (a)
CSA.8418 36
  • 22 (a)
Species with no ortholog for KLHL34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL34 Gene

Gene Tree for KLHL34 (if available)
Gene Tree for KLHL34 (if available)

Paralogs for KLHL34 Gene

genes like me logo Genes that share paralogs with KLHL34: view

Variants for KLHL34 Gene

Sequence variations from dbSNP and Humsavar for KLHL34 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4451438 -- 21,655,959(+) GCCCA(G/T)GGCAA synonymous-codon, reference
rs5904488 -- 21,655,349(+) TTAAC(A/C)AAGGC downstream-variant-500B
rs5904576 -- 21,656,331(+) CCCTC(C/G)CCTCT reference, synonymous-codon
rs12861104 -- 21,655,741(+) CTTCA(A/G)AAGCC utr-variant-3-prime
rs12861135 -- 21,655,759(+) TCCCA(A/G)AATCC utr-variant-3-prime

Relevant External Links for KLHL34 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLHL34 Gene

Disorders for KLHL34 Gene

No disorders were found for KLHL34 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KLHL34 Gene

Publications for KLHL34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KLHL34 Gene

Sources for KLHL34 Gene

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