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KLHL34 Gene(Protein Coding)

Kelch Like Family Member 34

GCID:
GC0XM021583
GIFtS:
41
Genes Participants
UDN Logo

Aliases for KLHL34 Gene

Aliases for KLHL34 Gene

  • Kelch Like Family Member 34 2 3 5
  • Kelch-Like 34 (Drosophila) 2
  • Kelch-Like Protein 34 3
  • Kelch-Like 34 3
  • RP11-450P7.3 3

External Ids for KLHL34 Gene

Previous GeneCards Identifiers for KLHL34 Gene

  • GC0XM019415

Summaries for KLHL34 Gene

GeneCards Summary for KLHL34 Gene

KLHL34 (Kelch Like Family Member 34) is a Protein Coding gene. An important paralog of this gene is KLHL9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL34 Gene

Genomics for KLHL34 Gene

Products:

  1. Regulatory Element

Regulatory Elements for KLHL34 Gene

Enhancers for KLHL34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF021658 0.7 ENCODE 0.8 -0.5 -463 1.1 ZNF202 ZNF680 ZNF266 ZNF140 ZBTB8A REST ZNF781 ZNF518A ZNF264 ZNF101 YY2 KLHL34 SMPX
GH0XF021655 0.4 Ensembl 0.8 +2.4 2387 0.4 ZNF366 KLHL34 PIR41368
GH0XF021740 0.9 ENCODE 0.2 -82.9 -82942 1.5 INSM2 FEZF1 RARA ZNF121 SCRT2 ZNF680 TSHZ1 ZNF518A ZNF843 SMARCA4 YY2 SMPX KLHL34
GH0XF021738 0.8 ENCODE 0.2 -80.3 -80331 0.2 PKNOX1 KLF17 FEZF1 ZIC2 ZNF2 HIC1 CTBP1 ZNF366 PRDM10 KLF8 SMPX KLHL34
GH0XF021742 0.7 ENCODE 0.2 -84.1 -84071 0.2 ZNF639 HLF INSM2 ATF2 OSR2 ZNF366 ZNF692 PRDM10 KLF8 TRIM28 SMPX KLHL34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL34 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001916165 -314 1399 ZNF202 ZNF654 ZNF680 ZNF266 ZNF140 ZBTB8A REST ZNF781 ZNF518A ZNF264

Transcription factor binding sites by QIAGEN in the KLHL34 gene promoter:

Genomic Location for KLHL34 Gene

Chromosome:
X
Start:
21,654,690 bp from pter
End:
21,658,387 bp from pter
Size:
3,698 bases
Orientation:
Minus strand

Genomic View for KLHL34 Gene

Genes around KLHL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL34 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KLHL34 Gene

Proteins for KLHL34 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KLHL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N239-KLH34_HUMAN
    Recommended name:
    Kelch-like protein 34
    Protein Accession:
    Q8N239

    Protein attributes for KLHL34 Gene

    Size:
    644 amino acids
    Molecular mass:
    70612 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL34 Gene

Protein Expression for KLHL34 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KLHL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL34 Gene

Domains & Families for KLHL34 Gene

Gene Families for KLHL34 Gene

HGNC:

Protein Domains for KLHL34 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KLHL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N239

UniProtKB/Swiss-Prot:

KLH34_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL34: view

Function for KLHL34 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL34: view

Phenotypes for KLHL34 Gene

GenomeRNAi human phenotypes for KLHL34:
genes like me logo Genes that share phenotypes with KLHL34: view

Animal Model Products

miRNA for KLHL34 Gene

miRTarBase miRNAs that target KLHL34

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL34 Gene

Localization for KLHL34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL34 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL34 Gene

Pathways & Interactions for KLHL34 Gene

SuperPathways for KLHL34 Gene

PathCards logo More details on SuperPathways for KLHL34
No Data Available

Gene Ontology (GO) - Biological Process for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL34: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL34 Gene

Drugs & Compounds for KLHL34 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for KLHL34 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for KLHL34 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL34 Gene

Kelch-like family member 34:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL34 Gene

No ASD Table

Relevant External Links for KLHL34 Gene

GeneLoc Exon Structure for
KLHL34
ECgene alternative splicing isoforms for
KLHL34

Expression for KLHL34 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL34 Gene

mRNA expression in normal human tissues for KLHL34 Gene
mRNA expression by BioGPS for KLHL34 GenemRNA expression by GTEx for KLHL34 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL34 Gene

This gene is overexpressed in Muscle - Skeletal (x23.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for KLHL34 Gene

This gene is overexpressed in Placenta (10.2), Testis (7.5), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL34 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLHL34 Gene:

KLHL34

SOURCE GeneReport for Unigene cluster for KLHL34 Gene:

Hs.448572
genes like me logo Genes that share expression patterns with KLHL34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KLHL34 Gene

Orthologs for KLHL34 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KLHL34 34 35
  • 98.94 (n)
cow
(Bos Taurus)
 Mammalia KLHL34 34 35
  • 87.06 (n)
dog
(Canis familiaris)
 Mammalia KLHL34 34 35
  • 86.43 (n)
mouse
(Mus musculus)
 Mammalia Klhl34 34 16 35
  • 79.68 (n)
rat
(Rattus norvegicus)
 Mammalia Klhl34 34
  • 78.9 (n)
oppossum
(Monodelphis domestica)
 Mammalia KLHL34 35
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KLHL34 34 35
  • 59.06 (n)
lizard
(Anolis carolinensis)
 Reptilia KLHL34 35
  • 53 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia klhl34 34
  • 53.5 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC561692 34
  • 50 (n)
KLHL34 35
  • 41 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG1812 35
  • 24 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 25 (a)
 OneToMany
-- 35
  • 23 (a)
 OneToMany
CSA.8418 35
  • 22 (a)
 OneToMany
Species where no ortholog for KLHL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL34 Gene

ENSEMBL:
Gene Tree for KLHL34 (if available)
TreeFam:
Gene Tree for KLHL34 (if available)

Paralogs for KLHL34 Gene

Paralogs for KLHL34 Gene

genes like me logo Genes that share paralogs with KLHL34: view

Variants for KLHL34 Gene

Sequence variations from dbSNP and Humsavar for KLHL34 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112016403 -- 21,656,406(+) AGAGC(C/T)CGCGG reference, synonymous-codon
rs112098587 -- 21,658,745(+) AGTGT(A/C)GACCT upstream-variant-2KB
rs12861104 -- 21,655,741(+) CTTCA(A/G)AAGCC utr-variant-3-prime
rs12861135 -- 21,655,759(+) TCCCA(A/G)AATCC utr-variant-3-prime
rs139183650 -- 21,656,928(+) CTGCG(C/T)CCCCC reference, synonymous-codon

Variation tolerance for KLHL34 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLHL34 Gene

Disorders for KLHL34 Gene

Relevant External Links for KLHL34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL34

No disorders were found for KLHL34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL34 Gene

Publications for KLHL34 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3 64
  5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3 64

Products for KLHL34 Gene

Sources for KLHL34 Gene

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