KLHL34 Gene
protein-coding GIFtS: 36
GCID: GC0XM021583
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Kelch-Like Family Member 34(Previous name: kelch-like 34 (Drosophila))
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Aliases
for KLHL34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 341 2 | | Kelch-Like 34 (Drosophila)1 | | Kelch-Like 342 | | Kelch-Like Protein 342 |
Export aliases for KLHL34 gene to outside databasesPrevious GC identifer: GC0XM019415 |
Summaries
for KLHL34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for KLHL34 Gene: 
KLHL34 (kelch-like family member 34) is a protein-coding gene. An important paralog of this gene is KLHL42.
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Genomic Views
for KLHL34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.2 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL34 gene promoter:
HFH-3 AhR C/EBPbeta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 YY1 C/EBPalpha FOXI1 Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.12 Ensembl cytogenetic band: Xp22.12 HGNC cytogenetic band: Xp22.12KLHL34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM021583: view genomic region
(about GC identifiers)
Start:
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21,673,609 bp from pter |
End:
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21,676,448 bp from pter |
Size:
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2,840 bases |
Orientation:
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minus strand |
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Proteins
for KLHL34 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239 (See
protein sequence)Recommended Name: Kelch-like protein 34 Size: 644 amino acids; 70612 DaExplore the universe of human proteins at neXtProt for KLHL34: NX_Q8N239
Explore proteomics data for KLHL34 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q8N239
KLHL34 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_695002.1
ENSEMBL proteins: ENSP00000368813
Human Recombinant Protein Products for KLHL34:
KLHL34 Antibody Products:
Assay Products for KLHL34: |
Protein
Domains /
Families
for KLHL34 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
BTBD: BTB/POZ domain containingKLHL: Kelch-like
5/7 InterPro protein domains (see all 7):Graphical View of Domain Structure for InterPro Entry Q8N239ProtoNet protein and cluster: Q8N239 2 Blocks protein domains: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH34_HUMAN, Q8N239Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats
KLHL34 for domains About GeneDecksing
|
Function
for KLHL34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005515 | protein binding |
-- | -- |
KLHL34 for ontologies About GeneDecksing
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for KLHL34 | |  | Search LifeMap BioReagents cell lines for KLHL34 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34 |
Pathways & Interactions
for KLHL34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL34
|
Drugs & Compounds
for KLHL34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL34 (KLH34)
Search CenterWatch for drugs/clinical trials and news about KLHL34 / KLH34
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Transcripts
for KLHL34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL34 gene: NM_153270.1 Unigene Cluster for KLHL34: Kelch-like family member 34 Hs.448572 [show with all ESTs]Unigene Representative Sequence: AK0922791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000379499(uc004czz.1)
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for KLHL34
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL34 |
Additional mRNA sequence: AK092279.1 BC109031.2 1 DOTS entry: DT.427299 10 AceView cDNA sequences: F23243 AK092279 AX747450 BX091412 NM_153270 AA744969 AI792308 AI733575 AI004659 AI792176
GeneLoc Exon Structure
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Expression
for KLHL34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL34 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAGTGCTGC
About this image
See KLHL34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL34
SOURCE GeneReport for Unigene cluster: Hs.448572
SABiosciences Custom PCR Arrays for KLHL34
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for KLHL34
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34 |
Orthologs
for KLHL34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for KLHL34 gene from 5/10 species (see all 10) About this table
ENSEMBL Gene Tree for KLHL34 (if available)
TreeFam Gene Tree for KLHL34 (if available) |
Paralogs
for KLHL34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL34 gene
- KLHL422 KLHL132 KLHL222 KLHL262 KLHL312 KBTBD132 KBTBD112 KLHL322
- KLHL92 KLHL142 KLHL152 KLHL362 KLHDC7B2 KLHL332 KLHDC7A2
KLHL34 for paralogs About GeneDecksing
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Genomic Variants
for KLHL34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for KLHL34 (21673609 - 21676448 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for KLHL34: --
Human Gene Mutation Database (HGMD): KLHL34
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing KLHL34 |
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Disorders
/ Diseases
for KLHL34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KLHL34 for disorders About MalaCards
KLHL34 for disorders About GeneDecksing
Export disorders for KLHL34 gene to outside databases
|
Publications
for KLHL34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL34 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHL34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KLHL34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KLHL34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL34 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KLHL34 gene:
Search GeneIP for patents involving KLHL34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL34 | | | QIAGEN SeqTarget long-range PCR primers for resequencing KLHL34 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL34 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL34 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL34 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KLHL34 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL34 |
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Last full update: 23 Oct 2013 -
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