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Aliases for KLHL33 Gene

Aliases for KLHL33 Gene

  • Kelch-Like Family Member 33 2 3
  • Kelch-Like 33 (Drosophila) 2
  • EC 63
  • EC 63

External Ids for KLHL33 Gene

Previous GeneCards Identifiers for KLHL33 Gene

  • GC14M019969
  • GC14M020896
  • GC14M001018

Summaries for KLHL33 Gene

GeneCards Summary for KLHL33 Gene

KLHL33 (Kelch-Like Family Member 33) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL33 Gene

Genomics for KLHL33 Gene

Regulatory Elements for KLHL33 Gene

Genomic Location for KLHL33 Gene

20,427,705 bp from pter
20,436,195 bp from pter
8,491 bases
Minus strand

Genomic View for KLHL33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL33 Gene

Proteins for KLHL33 Gene

  • Protein details for KLHL33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 33
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KLHL33 Gene

    533 amino acids
    Molecular mass:
    57810 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL33 Gene

Proteomics data for KLHL33 Gene at MOPED

Selected DME Specific Peptides for KLHL33 Gene

Post-translational modifications for KLHL33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL33 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for KLHL33 Gene

Gene Families for KLHL33 Gene


Protein Domains for KLHL33 Gene

Suggested Antigen Peptide Sequences for KLHL33 Gene

Graphical View of Domain Structure for InterPro Entry



  • A6NCF5
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL33: view

Function for KLHL33 Gene

Enzyme Numbers (IUBMB) for KLHL33 Gene

Gene Ontology (GO) - Molecular Function for KLHL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL33: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL33

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLHL33 Gene

Localization for KLHL33 Gene

Subcellular locations from

Jensen Localization Image for KLHL33 Gene COMPARTMENTS Subcellular localization image for KLHL33 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL33 Gene

Pathways for KLHL33 Gene

SuperPathways for KLHL33 Gene

No Data Available

Interacting Proteins for KLHL33 Gene

Gene Ontology (GO) - Biological Process for KLHL33 Gene


No data available for Pathways by source for KLHL33 Gene

Transcripts for KLHL33 Gene

mRNA/cDNA for KLHL33 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL33 Gene

Kelch-like family member 33:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL33

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL33 Gene

No ASD Table

Relevant External Links for KLHL33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL33 Gene

mRNA expression in normal human tissues for KLHL33 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL33 Gene

This gene is overexpressed in Muscle - Skeletal (26.4).

Protein differential expression in normal tissues for KLHL33 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLHL33 Gene

SOURCE GeneReport for Unigene cluster for KLHL33 Gene Hs.556014

genes like me logo Genes that share expressions with KLHL33: view

Expression partners for KLHL33 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL33 Gene

Orthologs for KLHL33 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL33 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL33 35
  • 88.56 (n)
  • 89.87 (a)
KLHL33 36
  • 60 (a)
(Canis familiaris)
Mammalia KLHL33 35
  • 76.25 (n)
  • 77.92 (a)
KLHL33 36
  • 72 (a)
(Mus musculus)
Mammalia Klhl33 35
  • 84.12 (n)
  • 84.8 (a)
Klhl33 16
Klhl33 36
  • 85 (a)
(Pan troglodytes)
Mammalia KLHL33 35
  • 99.31 (n)
  • 99.62 (a)
KLHL33 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl33 35
  • 83.99 (n)
  • 85.18 (a)
(Monodelphis domestica)
Mammalia KLHL33 36
  • 48 (a)
(Gallus gallus)
Aves LOC101750992 35
  • 53.75 (n)
  • 45.64 (a)
KLHL33 36
  • 32 (a)
(Anolis carolinensis)
Reptilia KLHL33 36
  • 38 (a)
(Danio rerio)
Actinopterygii LOC101884635 35
  • 46.11 (n)
  • 37.74 (a)
CT027762.3 36
  • 17 (a)
KLHL33 (1 of 3) 36
  • 25 (a)
KLHL33 (3 of 3) 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1812 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for KLHL33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL33 Gene

Gene Tree for KLHL33 (if available)
Gene Tree for KLHL33 (if available)

Paralogs for KLHL33 Gene

Selected SIMAP similar genes for KLHL33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLHL33: view

Variants for KLHL33 Gene

Sequence variations from dbSNP and Humsavar for KLHL33 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs882594 -- 20,428,365(-) TCCCA(C/T)CCCTG downstream-variant-500B, utr-variant-3-prime
rs938893 -- 20,436,982(-) CCATG(A/G)ATAAA upstream-variant-2KB
rs945012 -- 20,427,487(-) CAGAA(A/G)GAAGT downstream-variant-500B
rs1713408 -- 20,435,190(-) ATGCC(A/G)GGGAA intron-variant, reference, missense
rs1713450 -- 20,428,086(-) GTTTA(A/G)GGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL33 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Relevant External Links for KLHL33 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL33 Gene

Disorders for KLHL33 Gene

No disorders were found for KLHL33 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KLHL33 Gene

Publications for KLHL33 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3
  3. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4

Products for KLHL33 Gene

Sources for KLHL33 Gene

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