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Aliases for KLHL33 Gene

Aliases for KLHL33 Gene

  • Kelch Like Family Member 33 2 3 5
  • Kelch-Like 33 (Drosophila) 2
  • EC 61
  • EC 61

External Ids for KLHL33 Gene

Previous GeneCards Identifiers for KLHL33 Gene

  • GC14M019969
  • GC14M020896
  • GC14M001018

Summaries for KLHL33 Gene

GeneCards Summary for KLHL33 Gene

KLHL33 (Kelch Like Family Member 33) is a Protein Coding gene. An important paralog of this gene is KLHL9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL33 Gene

Genomics for KLHL33 Gene

Regulatory Elements for KLHL33 Gene

Enhancers for KLHL33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KLHL33 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KLHL33 Gene

20,425,870 bp from pter
20,436,310 bp from pter
10,441 bases
Minus strand

Genomic View for KLHL33 Gene

Genes around KLHL33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL33 Gene

Proteins for KLHL33 Gene

  • Protein details for KLHL33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 33
    Protein Accession:

    Protein attributes for KLHL33 Gene

    533 amino acids
    Molecular mass:
    57810 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL33 Gene

Selected DME Specific Peptides for KLHL33 Gene

Post-translational modifications for KLHL33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL33 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KLHL33 Gene

Gene Families for KLHL33 Gene

Protein Domains for KLHL33 Gene

Suggested Antigen Peptide Sequences for KLHL33 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 Kelch repeats.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL33: view

Function for KLHL33 Gene

Enzyme Numbers (IUBMB) for KLHL33 Gene

Gene Ontology (GO) - Molecular Function for KLHL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL33: view

Phenotypes for KLHL33 Gene

genes like me logo Genes that share phenotypes with KLHL33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLHL33 Gene

Localization for KLHL33 Gene

Subcellular locations from

Jensen Localization Image for KLHL33 Gene COMPARTMENTS Subcellular localization image for KLHL33 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLHL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IBA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL33: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL33 Gene

Pathways & Interactions for KLHL33 Gene

SuperPathways for KLHL33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL33: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL33 Gene

Drugs & Compounds for KLHL33 Gene

No Compound Related Data Available

Transcripts for KLHL33 Gene

mRNA/cDNA for KLHL33 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL33 Gene

Kelch-like family member 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL33 Gene

No ASD Table

Relevant External Links for KLHL33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL33 Gene

mRNA expression in normal human tissues for KLHL33 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL33 Gene

This gene is overexpressed in Muscle - Skeletal (x26.4).

Protein differential expression in normal tissues from HIPED for KLHL33 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL33 Gene

Protein tissue co-expression partners for KLHL33 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL33 Gene:


SOURCE GeneReport for Unigene cluster for KLHL33 Gene:

genes like me logo Genes that share expression patterns with KLHL33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL33 Gene

Orthologs for KLHL33 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL33 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL33 34
  • 88.56 (n)
  • 89.87 (a)
KLHL33 35
  • 60 (a)
(Canis familiaris)
Mammalia KLHL33 34
  • 76.25 (n)
  • 77.92 (a)
KLHL33 35
  • 72 (a)
(Mus musculus)
Mammalia Klhl33 34
  • 84.12 (n)
  • 84.8 (a)
Klhl33 16
Klhl33 35
  • 85 (a)
(Pan troglodytes)
Mammalia KLHL33 34
  • 99.31 (n)
  • 99.62 (a)
KLHL33 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl33 34
  • 83.99 (n)
  • 85.18 (a)
(Monodelphis domestica)
Mammalia KLHL33 35
  • 48 (a)
(Gallus gallus)
Aves LOC101750992 34
  • 53.75 (n)
  • 45.64 (a)
KLHL33 35
  • 32 (a)
(Anolis carolinensis)
Reptilia KLHL33 35
  • 38 (a)
(Danio rerio)
Actinopterygii LOC101884635 34
  • 46.11 (n)
  • 37.74 (a)
CT027762.3 35
  • 17 (a)
KLHL33 (1 of 3) 35
  • 25 (a)
KLHL33 (3 of 3) 35
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1812 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
Species where no ortholog for KLHL33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL33 Gene

Gene Tree for KLHL33 (if available)
Gene Tree for KLHL33 (if available)

Paralogs for KLHL33 Gene

(2) SIMAP similar genes for KLHL33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLHL33: view

Variants for KLHL33 Gene

Sequence variations from dbSNP and Humsavar for KLHL33 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs12587478 - 20,430,188(+) CAAAG(C/T)GGACA reference, missense
rs17242648 - 20,430,149(+) CTGCC(C/T)GCACC reference, missense
rs1953225 - 20,429,517(-) CCCTG(A/G)GCTCA reference, missense
rs7145318 - 20,428,905(+) CACAG(C/T)GGGCA reference, missense
rs7140768 -- 20,428,698(+) CTCAA(C/T)GGAGA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL33 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545
nsv1150986 CNV insertion 26484159

Variation tolerance for KLHL33 Gene

Gene Damage Index Score: 11.60; 93.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL33 Gene

Disorders for KLHL33 Gene

Relevant External Links for KLHL33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL33 Gene

Publications for KLHL33 Gene

  1. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3 65
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3 65
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for KLHL33 Gene

Sources for KLHL33 Gene

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