KLHL32 Gene
protein-coding GIFtS : 44
GCID: GC06 P097372
kelch-like family member 32 (Previous names: BTB and kelch domain containing 5, KIAA1900, kelch-like... ) (Previous symbols: BKLHD5, KIAA1900 )
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Aliasesfor KLHL32 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Kelch-Like Family Member 32 1 2 Kelch-Like 32 (Drosophila)1 BKLHD51 2 3 UG0030H052 KIAA19001 2 3 DJ21F7.11 BTB And Kelch Domain Containing 51 2 Kelch-Like 322 BTB And Kelch Domain-Containing Protein 52 3 Kelch-Like Protein 322
Export aliases for KLHL32 gene to outside databases Previous GC identifers: GC06P097480 GC06P094806
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Summariesfor KLHL32 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor KLHL32 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KLHL32 gene promoter: POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 E47 AREB6 POU2F1 POU2F1a POU2F1b POU2F1c Other transcription factors Search SABiosciences Chromatin IP Primers for KLHL32 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KLHL32
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q16.1 Ensembl cytogenetic band: 6q16.1 HGNC cytogenetic band: 6q16.3 KLHL32 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P097372: view genomic region
(about GC identifiers )
Start:
97,372,496 bp from pter
End:
97,588,630 bp from pter
Size:
216,135 bases
Orientation:
plus strand
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Proteinsfor KLHL32 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KLH32_HUMAN, Q96NJ5 (See
protein sequence )Recommended Name: Kelch-like protein 32 Size : 620 amino acids; 70362 Da
Secondary accessions : E1P528 Q5THT0 Q96PY7Explore the universe of human proteins at neXtProt for KLHL32: NX_Q96NJ5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96NJ5 KLHL32 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_443136.2 ENSEMBL proteins: ENSP00000358265 ENSP00000358258 ENSP00000389310 ENSP00000440382 ENSP00000441527 ENSP00000445453 Human Recombinant Protein Products: KLHL32 Antibody Products: Assay Products for KLHL32:
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Protein
Domains / Familiesfor KLHL32 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KLHL32 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q96NJ5 ProtoNet protein and cluster: Q96NJ5
2 Blocks protein families : IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated UniProtKB/Swiss-Prot: KLH32_HUMAN, Q96NJ5 Similarity : Contains 1 BTB (POZ) domainSimilarity : Contains 6 Kelch repeats
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Functionfor KLHL32 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL32 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL32OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLHL32 (NM_052904 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL32 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHL32
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL32
4 GenomeRNAi human phenotypes for KLHL32 :
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Pathways & Interactionsfor KLHL32 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL32
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Drugs & Compoundsfor KLHL32 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KLHL32 Search CenterWatch for drugs/clinical trials and news about KLHL32 / KLH32
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Transcriptsfor KLHL32 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KLHL32 gene: NM_052904.3 Unigene Cluster for KLHL32:
Kelch-like 32 (Drosophila) Hs.45056 [show with all ESTs ] Unigene Representative Sequence: NM_052904 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000369261 (uc003poy.3 uc010kcm.1 uc003poz.2 uc011ead.1 uc011eae.1 uc003ppa.2 )ENST00000369254 ENST00000447886 ENST00000536676 ENST00000539200 ENST00000544166 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL32 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL32OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLHL32 (NM_052904 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL32 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHL32
Additional cDNA sequence: AB067487.1 AF351610.1 AK055292.1 AK295479.1 AK297240.1 BC047491.1 BC071627.1
4 DOTS entries : DT.91916547 DT.91868299
DT.101968250 DT.92041737 24 AceView cDNA sequences :
AB067487 BC031830 BC047491 BG181952 BF352946 BC071627 AF351610 BX493379 BG202967 BI916261 BI669996 BI917115 T10232 AK055292 BU854426 NM_052904 BX645412 BX103232 N40195 BI919226 BI601157 BG256423 BI915330 T10233 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL32 (see all 6 ) About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b SP1 :           -       -         -             SP2 :                 -   -   -   -   -             SP3 :           -     -   -   -   -   -   -             SP4 :           -       -                     SP5 :                                    
ECgene alternative splicing isoforms for KLHL32
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Expression for KLHL32 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KLHL32 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAACCTTTTT
About this image KLHL32 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Inner Nuclear Layer Mature Horizontal Cells Horizontal, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See KLHL32 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KLHL32 SOURCE GeneReport for Unigene cluster: Hs.45056 SABiosciences Custom PCR Arrays for KLHL32 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KLHL32Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KLHL32 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLHL32 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLHL32 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL32
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Orthologsfor KLHL32 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for KLHL32 gene from 5/13 species (see all 13 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
KLHL321
kelch-like 32 (Drosophila)
82.9(n) 94.19(a)
 
421801 XM_419827.3 XP_419827.2
lizard (Anolis carolinensis)
Reptilia
KLHL326
--
91(a)
1 ↔ 1
1(173464733-173535347)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.146022
Transcribed sequence with weak similarity to protein more
78.57(n)
 
BX701680.1
zebrafish (Danio rerio)
Actinopterygii
klhl321
kelch-like 32 (Drosophila)
72.31(n) 80(a)
 
100009653 NM_001083022.1 NP_001076491.1
fruit fly (Drosophila melanogaster)
Insecta
CG18126
--
24(a)
1 → many
X(20382574-20386859)
ENSEMBL Gene Tree for KLHL32 (if available)TreeFam Gene Tree for KLHL32 (if available)
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Paralogsfor KLHL32 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KLHL32 gene KLHL42 2 KLHL13 2 KLHL22 2 KLHL26 2 KLHL34 2 KBTBD13 2 KBTBD11 2 KLHL31 2 KLHL9 2 KLHL14 2 KLHDC7B 2 KLHL15 2 KLHL36 2 KLHL33 2 KLHDC7A 2 18/67 SIMAP similar genes for KLHL32 using alignment to 6 protein entries: KLH32_HUMAN (see all proteins )
(see all similar genes ):KIAA1900 ZBTB7C BACH2 ZBTB17 ZNF295 ZBTB4 ZBTB3 KLHL2 ZBTB14 KLHL1 ZBTB44 KLHL7 KLHL17 ZBTB25 ZBTB38 ZBTB47 ZBTB8B KLHL22
KLHL32 for paralogs About GeneDecksing
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Genomic Variantsfor KLHL32 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KLHL32 (97372496 - 97588630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 14 variations for KLHL32 10 CNVs : 99634 23818 93903 93902 81505 22653 64602 93905 93904 93901 4 Indels : 47187 47188 62550 81506
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLHL32
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Disorders
/ Diseasesfor KLHL32 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor KLHL32 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KLHL32 gene integrated from 9 sources : (articles sorted by number of sources associating them with KLHL32) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484) 1 , 2 Nagase T....Ohara O. (2001) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 2 Mungall A.J.... Beck S. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KLHL32 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KLHL32 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KLHL32 gene
(According to HUGE )
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Specialized Databases showing KLHL32 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KLHL32 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KLHL32 gene: Search GeneIP for patents involving KLHL32 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KLHL32 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KLHL32 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KLHL32 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KLHL32 OriGene Protein Over-expression Lysate for KLHL32 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KLHL32 OriGene 3'-UTR Clone for KLHL32 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL32 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL32 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KLHL32 OriGene Custom Protein Services for KLHL32 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL32 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLHL32 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KLHL32 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KLHL32 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLHL32 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLHL32
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KLHL32 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL32
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHL32
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Aliases for KLHL32
Databases for KLHL32
Disorders / Diseases for KLHL32
Domains / Families for KLHL32
Drugs / Compounds for KLHL32
Expression for KLHL32
Function for KLHL32
Genomic Views for KLHL32
Intellectual Property for KLHL32
Orthologs for KLHL32
Paralogs for KLHL32
Pathways / Interactions for KLHL32
Products for KLHL32
Proteins for KLHL32
Publications for KLHL32
Search Box for KLHL32
Summaries for KLHL32
Transcripts for KLHL32
Variants for KLHL32
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